GRXCR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a glutaredoxin domain, which functions in protein S-glutathionylation. A mutation in this gene was found in a family with autoosomal recessive nonsyndromic sensorineural deafness-101. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1inner ear receptor cell differentiation (GO:0060113)8.03854151
2hair cell differentiation (GO:0035315)7.42842396
3mechanoreceptor differentiation (GO:0042490)7.23204802
4imidazole-containing compound metabolic process (GO:0052803)6.78688016
5synaptic vesicle exocytosis (GO:0016079)5.70220308
6pentose metabolic process (GO:0019321)5.50027068
7detection of temperature stimulus (GO:0016048)5.37399201
8detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.33363754
9detection of temperature stimulus involved in sensory perception (GO:0050961)5.33363754
10retinal ganglion cell axon guidance (GO:0031290)5.30396342
11cranial nerve development (GO:0021545)5.07048657
12righting reflex (GO:0060013)5.01636149
13positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.74760313
14negative regulation of calcium ion transport into cytosol (GO:0010523)4.55854057
15sensory perception of sound (GO:0007605)4.36387402
16sensory perception of mechanical stimulus (GO:0050954)4.35666945
17diterpenoid biosynthetic process (GO:0016102)4.32070007
18G-protein coupled receptor internalization (GO:0002031)4.18659845
19regulation of cardioblast proliferation (GO:0003264)4.12157031
20regulation of secondary heart field cardioblast proliferation (GO:0003266)4.12157031
21inner ear morphogenesis (GO:0042472)4.06559765
22reflex (GO:0060004)4.02097691
23cranial nerve morphogenesis (GO:0021602)3.98992935
24negative regulation of sodium ion transport (GO:0010766)3.96753425
25axon extension (GO:0048675)3.80283585
26neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.79716038
27limb bud formation (GO:0060174)3.79031520
28endocardial cushion morphogenesis (GO:0003203)3.72207547
29regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.68058340
30glutamate secretion (GO:0014047)3.66425521
31nerve development (GO:0021675)3.62570356
32adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.59125248
33neuromuscular process controlling balance (GO:0050885)3.36836931
34retinal metabolic process (GO:0042574)3.36428264
35response to prostaglandin E (GO:0034695)3.32537636
36negative regulation of oligodendrocyte differentiation (GO:0048715)3.32143526
37aorta morphogenesis (GO:0035909)3.31374476
38neuron projection extension (GO:1990138)3.31038363
39neuronal action potential propagation (GO:0019227)3.30355946
40regulation of short-term neuronal synaptic plasticity (GO:0048172)3.29618058
41positive regulation of receptor biosynthetic process (GO:0010870)3.29058599
42terpenoid biosynthetic process (GO:0016114)3.17274606
43regulation of interleukin-8 biosynthetic process (GO:0045414)3.15322814
44lung epithelium development (GO:0060428)3.14876448
45negative regulation of bone remodeling (GO:0046851)3.13127604
46negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.12729033
47auditory behavior (GO:0031223)3.07060299
48cardiac right ventricle morphogenesis (GO:0003215)2.91703874
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.91061225
50sympathetic nervous system development (GO:0048485)2.90697194
51synaptic transmission, cholinergic (GO:0007271)2.88871876
52regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.87560255
53regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.87560255
54mesenchyme morphogenesis (GO:0072132)2.86236215
55regulation of somitogenesis (GO:0014807)2.76195760
56detection of mechanical stimulus (GO:0050982)2.74337945
57regulation of T-helper 1 cell differentiation (GO:0045625)2.73772870
58regulation of transforming growth factor beta2 production (GO:0032909)2.72844501
59amine biosynthetic process (GO:0009309)2.72375940
60cellular biogenic amine biosynthetic process (GO:0042401)2.72375940
61regulation of dendritic cell antigen processing and presentation (GO:0002604)2.72258224
62mechanosensory behavior (GO:0007638)2.71910328
63positive regulation of synapse assembly (GO:0051965)2.71191651
64negative regulation of Ras GTPase activity (GO:0034261)2.66319876
65positive regulation of interleukin-1 production (GO:0032732)2.65771004
66neuromuscular process (GO:0050905)2.64360050
67behavioral response to cocaine (GO:0048148)2.62034597
68retinoic acid metabolic process (GO:0042573)2.61895081
69vocalization behavior (GO:0071625)2.59589342
70face development (GO:0060324)2.59179978
71developmental cell growth (GO:0048588)2.58316407
72regulation of lipoprotein particle clearance (GO:0010984)2.57533069
73negative regulation of osteoclast differentiation (GO:0045671)2.57376286
74regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.57315028
75negative regulation of tissue remodeling (GO:0034104)2.55875254
76calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.55610824
77neuron cell-cell adhesion (GO:0007158)2.54692189
78digestive tract morphogenesis (GO:0048546)2.54368913
79generation of neurons (GO:0048699)2.54276798
80regulation of heart morphogenesis (GO:2000826)2.52459005
81regulation of dopamine secretion (GO:0014059)2.52295984
82regulation of sodium ion transmembrane transporter activity (GO:2000649)2.51790452
83lateral sprouting from an epithelium (GO:0060601)2.51614542
84synaptic transmission, dopaminergic (GO:0001963)2.51312570
85response to prostaglandin (GO:0034694)2.50707041
86cell migration in hindbrain (GO:0021535)2.50160263
87transmission of nerve impulse (GO:0019226)2.48484139
88dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.47063688
89pharyngeal system development (GO:0060037)2.43461535
90synaptic vesicle maturation (GO:0016188)2.43263923
91regulation of glucocorticoid secretion (GO:2000849)2.43222422
92response to histamine (GO:0034776)2.40945692
93regulation of synapse assembly (GO:0051963)2.40487603
94peptide catabolic process (GO:0043171)2.39998512
95lung vasculature development (GO:0060426)2.39423207
96arachidonic acid secretion (GO:0050482)2.39354545
97icosanoid secretion (GO:0032309)2.39354545
98neuron recognition (GO:0008038)2.39239269
99regulation of corticosteroid hormone secretion (GO:2000846)2.38757969
100auditory receptor cell differentiation (GO:0042491)12.1547393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.83113939
2IGF1R_20145208_ChIP-Seq_DFB_Human2.98855358
3VDR_22108803_ChIP-Seq_LS180_Human2.89987999
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83990214
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62991159
6SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.62522600
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57698333
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57556013
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57556013
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47456590
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39885392
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34547248
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32127230
14AR_21572438_ChIP-Seq_LNCaP_Human2.28325376
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26741252
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.25711248
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.18184154
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11098387
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06680481
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04741229
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.04518875
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02663187
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.99912972
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91323374
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.90492137
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77051544
27AHR_22903824_ChIP-Seq_MCF-7_Human1.76488158
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75466896
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.75375215
30TAF15_26573619_Chip-Seq_HEK293_Human1.70633611
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67498659
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.65545099
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.63505593
34GBX2_23144817_ChIP-Seq_PC3_Human1.63178747
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.56269277
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.51946992
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49940960
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48760825
39RXR_22108803_ChIP-Seq_LS180_Human1.48008860
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44921495
41REST_21632747_ChIP-Seq_MESCs_Mouse1.44694457
42DROSHA_22980978_ChIP-Seq_HELA_Human1.42584872
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.40749653
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40739332
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35992211
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34615810
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33106880
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30974443
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.30069087
50TP53_18474530_ChIP-ChIP_U2OS_Human1.29481685
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28927528
52P300_19829295_ChIP-Seq_ESCs_Human1.26804845
53SMAD4_21799915_ChIP-Seq_A2780_Human1.26733448
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.25555388
55BCAT_22108803_ChIP-Seq_LS180_Human1.20490440
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.15583567
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.15526426
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.15183678
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14973738
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14443831
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.12190119
62* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12005779
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11485021
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11276305
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.09049476
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08355915
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.07966127
68STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06006763
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.04404369
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03489342
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01692795
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01624018
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00581015
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00396060
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99998389
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99526458
77CTCF_27219007_Chip-Seq_Bcells_Human0.99141034
78RNF2_27304074_Chip-Seq_NSC_Mouse0.98376348
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96994993
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96994993
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96994993
82AR_25329375_ChIP-Seq_VCAP_Human0.95307860
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95275279
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94464892
85* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94350062
86CJUN_26792858_Chip-Seq_BT549_Human0.93851648
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93584261
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93525967
89FUS_26573619_Chip-Seq_HEK293_Human0.92807365
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.90618455
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90088408
92CBP_20019798_ChIP-Seq_JUKART_Human0.90088408
93P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89935731
94CBX2_27304074_Chip-Seq_ESCs_Mouse0.89208483
95NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88893263
96KDM2B_26808549_Chip-Seq_REH_Human0.88823710
97TCF4_22108803_ChIP-Seq_LS180_Human0.88456460
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87377186
99* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87250424
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87090871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003879_abnormal_hair_cell8.16417477
2MP0001485_abnormal_pinna_reflex7.17714213
3MP0005377_hearing/vestibular/ear_phenot6.06001028
4MP0003878_abnormal_ear_physiology6.06001028
5MP0002735_abnormal_chemical_nociception4.08096104
6MP0006276_abnormal_autonomic_nervous3.95676105
7MP0000026_abnormal_inner_ear3.52351899
8MP0001963_abnormal_hearing_physiology3.36998558
9MP0001486_abnormal_startle_reflex3.05346291
10MP0004742_abnormal_vestibular_system2.90896024
11MP0005645_abnormal_hypothalamus_physiol2.43980550
12MP0005248_abnormal_Harderian_gland2.34171681
13MP0003938_abnormal_ear_development2.07926114
14MP0005451_abnormal_body_composition2.07283158
15MP0004270_analgesia1.90127544
16MP0002877_abnormal_melanocyte_morpholog1.69285188
17MP0004859_abnormal_synaptic_plasticity1.68551372
18MP0002876_abnormal_thyroid_physiology1.68179313
19MP0002734_abnormal_mechanical_nocicepti1.62286582
20MP0001502_abnormal_circadian_rhythm1.59034989
21MP0002184_abnormal_innervation1.55129741
22MP0001348_abnormal_lacrimal_gland1.48048482
23MP0002653_abnormal_ependyma_morphology1.46646310
24MP0001346_abnormal_lacrimal_gland1.44109867
25MP0001440_abnormal_grooming_behavior1.35262700
26MP0000762_abnormal_tongue_morphology1.30688292
27MP0002249_abnormal_larynx_morphology1.26337105
28MP0009384_cardiac_valve_regurgitation1.25807397
29MP0004858_abnormal_nervous_system1.24176532
30MP0009780_abnormal_chondrocyte_physiolo1.23509672
31MP0004885_abnormal_endolymph1.23376514
32MP0002751_abnormal_autonomic_nervous1.22102626
33MP0002132_abnormal_respiratory_system1.20623639
34MP0002733_abnormal_thermal_nociception1.20070550
35MP0002272_abnormal_nervous_system1.18352039
36MP0001968_abnormal_touch/_nociception1.16241040
37MP0001970_abnormal_pain_threshold1.15466945
38MP0010234_abnormal_vibrissa_follicle1.11873368
39MP0004134_abnormal_chest_morphology1.11708903
40MP0002102_abnormal_ear_morphology1.11632030
41MP0002822_catalepsy1.08723941
42MP0001299_abnormal_eye_distance/1.07794909
43MP0002254_reproductive_system_inflammat1.05825514
44MP0002752_abnormal_somatic_nervous1.05368585
45MP0005623_abnormal_meninges_morphology1.01677851
46MP0000534_abnormal_ureter_morphology1.01035974
47MP0001849_ear_inflammation0.93797906
48MP0009745_abnormal_behavioral_response0.93219711
49MP0009046_muscle_twitch0.89719182
50MP0002067_abnormal_sensory_capabilities0.89495984
51MP0002277_abnormal_respiratory_mucosa0.89275020
52MP0002882_abnormal_neuron_morphology0.88439807
53MP0003136_yellow_coat_color0.88404039
54MP0002233_abnormal_nose_morphology0.87843149
55MP0005187_abnormal_penis_morphology0.86803257
56MP0003635_abnormal_synaptic_transmissio0.86448239
57MP0002638_abnormal_pupillary_reflex0.84516189
58MP0004510_myositis0.84409640
59MP0000372_irregular_coat_pigmentation0.81452118
60MP0008789_abnormal_olfactory_epithelium0.78802696
61MP0000681_abnormal_thyroid_gland0.76046463
62MP0002736_abnormal_nociception_after0.75976112
63MP0002229_neurodegeneration0.74785659
64MP0002282_abnormal_trachea_morphology0.73872433
65MP0010386_abnormal_urinary_bladder0.71466961
66MP0002063_abnormal_learning/memory/cond0.70833887
67MP0010678_abnormal_skin_adnexa0.70380675
68MP0000678_abnormal_parathyroid_gland0.70010832
69MP0002572_abnormal_emotion/affect_behav0.66848400
70MP0009250_abnormal_appendicular_skeleto0.66720103
71MP0001986_abnormal_taste_sensitivity0.66190929
72MP0002837_dystrophic_cardiac_calcinosis0.64421329
73MP0000427_abnormal_hair_cycle0.64416042
74MP0003941_abnormal_skin_development0.62468977
75MP0000778_abnormal_nervous_system0.61412796
76MP0002064_seizures0.61388618
77MP0001905_abnormal_dopamine_level0.60054736
78MP0003942_abnormal_urinary_system0.54796746
79MP0008874_decreased_physiological_sensi0.54307816
80MP0008872_abnormal_physiological_respon0.53822077
81MP0003755_abnormal_palate_morphology0.52848823
82MP0008569_lethality_at_weaning0.52127823
83MP0001542_abnormal_bone_strength0.51865345
84MP0006072_abnormal_retinal_apoptosis0.49735336
85MP0000049_abnormal_middle_ear0.48255037
86MP0004147_increased_porphyrin_level0.46925115
87MP0002066_abnormal_motor_capabilities/c0.46107138
88MP0010030_abnormal_orbit_morphology0.45940864
89MP0005408_hypopigmentation0.45588596
90MP0001270_distended_abdomen0.44435758
91MP0005535_abnormal_body_temperature0.44300354
92MP0000613_abnormal_salivary_gland0.43913375
93MP0000383_abnormal_hair_follicle0.42520531
94MP0001727_abnormal_embryo_implantation0.42291385
95MP0005448_abnormal_energy_balance0.42286109
96MP0003011_delayed_dark_adaptation0.40700792
97MP0002177_abnormal_outer_ear0.40415125
98MP0002116_abnormal_craniofacial_bone0.40082459
99MP0005508_abnormal_skeleton_morphology0.39497532
100MP0001340_abnormal_eyelid_morphology0.36244808

Predicted human phenotypes

RankGene SetZ-score
1Abnormal auditory evoked potentials (HP:0006958)7.52192842
2Epiphyseal dysplasia (HP:0002656)5.39086638
3Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.03689758
4Congenital sensorineural hearing impairment (HP:0008527)4.85070886
5Irregular epiphyses (HP:0010582)4.50415055
6Abnormality of the aortic arch (HP:0012303)4.48730923
7Lip pit (HP:0100267)4.17499887
8Mixed hearing impairment (HP:0000410)4.12507142
9Amyloidosis (HP:0011034)4.01187147
10Severe Myopia (HP:0011003)3.99069031
11Vitreoretinal degeneration (HP:0000655)3.82332853
12Abnormality of the ischium (HP:0003174)3.76473724
13Abnormality of the pubic bones (HP:0003172)3.73102979
14Hypoplastic ischia (HP:0003175)3.67608310
15Bilateral microphthalmos (HP:0007633)3.39921149
16Upper limb muscle weakness (HP:0003484)3.34354754
17Hyperthyroidism (HP:0000836)3.28718533
18Myokymia (HP:0002411)3.25516829
19Bicornuate uterus (HP:0000813)3.23780314
20Annular pancreas (HP:0001734)3.04955051
21Focal motor seizures (HP:0011153)3.02635057
22Prolonged neonatal jaundice (HP:0006579)2.97010426
23Congenital malformation of the right heart (HP:0011723)2.96980050
24Double outlet right ventricle (HP:0001719)2.96980050
25Termporal pattern (HP:0011008)2.80249150
26Insidious onset (HP:0003587)2.80249150
27Aplasia involving bones of the upper limbs (HP:0009823)2.75467785
28Aplasia of the phalanges of the hand (HP:0009802)2.75467785
29Aplasia involving bones of the extremities (HP:0009825)2.75467785
30Arterial tortuosity (HP:0005116)2.71512908
31Microglossia (HP:0000171)2.70658771
32Anophthalmia (HP:0000528)2.70484744
33Conical tooth (HP:0000698)2.66314508
34Alacrima (HP:0000522)2.60992784
35Mild short stature (HP:0003502)2.59364370
36Action tremor (HP:0002345)2.46991854
37Abnormality of permanent molar morphology (HP:0011071)2.45809935
38Abnormality of the dental root (HP:0006486)2.45809935
39Taurodontia (HP:0000679)2.45809935
40Ulnar claw (HP:0001178)2.45644676
41Bell-shaped thorax (HP:0001591)2.41539501
42Hypothermia (HP:0002045)2.37020486
43Truncus arteriosus (HP:0001660)2.36949778
44Abnormality of molar (HP:0011077)2.36661617
45Abnormality of molar morphology (HP:0011070)2.36661617
46Vascular tortuosity (HP:0004948)2.31277740
47Atonic seizures (HP:0010819)2.29216861
48Concave nail (HP:0001598)2.28701170
49Flattened epiphyses (HP:0003071)2.25692860
50Down-sloping shoulders (HP:0200021)2.20894979
51Wrist flexion contracture (HP:0001239)2.19398169
52Seborrheic dermatitis (HP:0001051)2.17781857
53Preauricular pit (HP:0004467)2.16843928
54Periauricular skin pits (HP:0100277)2.16843928
55Abnormality of the dental pulp (HP:0006479)2.12893979
56Morphological abnormality of the middle ear (HP:0008609)2.08058714
57Autoamputation (HP:0001218)2.08030845
58Vertebral clefting (HP:0008428)2.07313988
59Hypoventilation (HP:0002791)2.05817175
60Abnormality of the lacrimal duct (HP:0011481)2.04535921
61Optic nerve hypoplasia (HP:0000609)2.01190993
62Hyperventilation (HP:0002883)2.00734776
63Epileptic encephalopathy (HP:0200134)1.96977427
64Absent epiphyses (HP:0010577)1.96393279
65Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96393279
66Aqueductal stenosis (HP:0002410)1.95302686
67Papilledema (HP:0001085)1.93700644
68Midline defect of the nose (HP:0004122)1.93596861
69Genu varum (HP:0002970)1.92493554
70Abnormality of the vitreous humor (HP:0004327)1.92326162
71Fibular aplasia (HP:0002990)1.90676806
72Pheochromocytoma (HP:0002666)1.90300229
73Exotropia (HP:0000577)1.88216680
74Ketoacidosis (HP:0001993)1.87728595
75Hypoplastic nipples (HP:0002557)1.87573883
76Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86660853
77Abnormality of the parathyroid morphology (HP:0011766)1.86461395
78Absent eyebrow (HP:0002223)1.85412651
79Synostosis involving the elbow (HP:0003938)1.85395786
80Humeroradial synostosis (HP:0003041)1.85395786
81Focal seizures (HP:0007359)1.83013925
82Abnormality of the labia minora (HP:0012880)1.81874395
83Poor suck (HP:0002033)1.81796483
84Oligodactyly (HP:0012165)1.81741171
85Fragile nails (HP:0001808)1.79842940
86Long clavicles (HP:0000890)1.79673890
87Plantar hyperkeratosis (HP:0007556)1.79643327
88Febrile seizures (HP:0002373)1.78717777
89Osteoarthritis (HP:0002758)1.78105112
90Nasolacrimal duct obstruction (HP:0000579)1.77721196
91Muscle fibrillation (HP:0010546)1.77448728
92Hypoplasia of the uterus (HP:0000013)1.77275364
93Onion bulb formation (HP:0003383)1.76633458
94Premature skin wrinkling (HP:0100678)1.76297346
95Shallow orbits (HP:0000586)1.75448941
96Abnormal pancreas size (HP:0012094)1.73232854
97Tongue fasciculations (HP:0001308)1.71076862
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70591170
99Unilateral renal agenesis (HP:0000122)1.67624388
100Renal hypoplasia (HP:0000089)1.66949045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.63452660
2EPHA34.44547131
3MAP3K123.59877065
4MINK13.09366538
5NTRK12.87749870
6CASK2.74984261
7EPHA22.72387794
8EPHB12.50391884
9LATS22.48601884
10BCR2.13928561
11ERBB42.13390582
12KSR21.93525703
13FER1.90299967
14ADRBK21.86399068
15NTRK31.82673903
16MST41.78820009
17FGFR41.65506313
18MAP2K41.56458506
19BMPR21.54997143
20MAP3K91.53960475
21RIPK41.53085018
22MAP3K41.50210648
23LIMK11.33606439
24TRPM71.26725309
25HIPK21.26027509
26MAPK151.21983690
27SIK31.21566456
28MAP2K71.19925185
29CSNK1A1L1.19824805
30PRKCE1.18606564
31ARAF1.18037570
32MAP2K11.15280988
33LATS11.15090508
34PTK2B1.08799392
35CSNK1G31.05560696
36DAPK21.02385829
37MAP3K141.00492043
38NME10.98260882
39FGFR30.97981212
40PAK30.97892894
41LMTK20.94539032
42RET0.93120082
43MAPK130.91510303
44GRK50.91201019
45MATK0.89628299
46CDK80.88868179
47KSR10.88743745
48PTK60.88403024
49PAK60.86007862
50IRAK10.85899158
51MAP3K20.85083483
52CDC42BPA0.84892651
53ROCK20.84618919
54CSNK1G20.82199281
55STK390.82059482
56MAP3K10.77278515
57DYRK20.75680314
58CSNK1G10.75676253
59PLK20.74666647
60CDK50.69654584
61UHMK10.65913612
62EPHA40.64081984
63MAP3K60.63648294
64ALK0.62838501
65CAMK2A0.61509316
66DYRK1B0.61174259
67PRKCH0.57946623
68ADRBK10.54225603
69ERBB20.53810171
70ITK0.50038655
71PRKCG0.47500144
72EPHB20.45550242
73YES10.45523493
74NTRK20.44684957
75MYLK0.44345334
76MAP2K20.44138301
77CAMK2D0.43974759
78WNK40.42224748
79CAMKK20.41526959
80NLK0.41414110
81RPS6KA20.37061100
82GRK10.36904582
83CAMKK10.35181680
84SRC0.35138880
85CAMK2G0.34839599
86CDK140.33267871
87EGFR0.33060647
88PRKD30.32752553
89DAPK10.32423722
90MAP3K70.32384289
91CAMK2B0.32323770
92AKT30.30883772
93PTK20.30786198
94PDK40.30593809
95PDK30.30593809
96STK380.30392185
97JAK20.29842088
98MARK10.27588314
99SGK2230.27057877
100SGK4940.27057877

Predicted pathways (KEGG)

RankGene SetZ-score
1Histidine metabolism_Homo sapiens_hsa003403.17329896
2Synaptic vesicle cycle_Homo sapiens_hsa047212.79191408
3Phenylalanine metabolism_Homo sapiens_hsa003602.32233340
4Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.96191870
5Melanoma_Homo sapiens_hsa052181.95791907
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.94031946
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87204018
8Nicotine addiction_Homo sapiens_hsa050331.80803422
9Gastric acid secretion_Homo sapiens_hsa049711.74173070
10Dopaminergic synapse_Homo sapiens_hsa047281.67183158
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62167596
12Asthma_Homo sapiens_hsa053101.61200415
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59894978
14Amphetamine addiction_Homo sapiens_hsa050311.57655897
15Dorso-ventral axis formation_Homo sapiens_hsa043201.52631134
16Axon guidance_Homo sapiens_hsa043601.48688404
17Olfactory transduction_Homo sapiens_hsa047401.47885225
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42292907
19Collecting duct acid secretion_Homo sapiens_hsa049661.41454791
20Hippo signaling pathway_Homo sapiens_hsa043901.35796543
21Glutamatergic synapse_Homo sapiens_hsa047241.35064656
22Insulin secretion_Homo sapiens_hsa049111.34023820
23Cocaine addiction_Homo sapiens_hsa050301.33058231
24Melanogenesis_Homo sapiens_hsa049161.26725907
25GABAergic synapse_Homo sapiens_hsa047271.25612980
26Salivary secretion_Homo sapiens_hsa049701.23297503
27Tight junction_Homo sapiens_hsa045301.23179781
28Wnt signaling pathway_Homo sapiens_hsa043101.22008000
29Cholinergic synapse_Homo sapiens_hsa047251.21520959
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17246402
31Serotonergic synapse_Homo sapiens_hsa047261.15516484
32Renin secretion_Homo sapiens_hsa049241.12336091
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11554786
34beta-Alanine metabolism_Homo sapiens_hsa004101.10243792
35Circadian entrainment_Homo sapiens_hsa047131.09798551
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08838953
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08694372
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06702309
39Long-term potentiation_Homo sapiens_hsa047201.06483318
40Basal cell carcinoma_Homo sapiens_hsa052171.05469631
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03677024
42ErbB signaling pathway_Homo sapiens_hsa040121.03670316
43Taste transduction_Homo sapiens_hsa047421.02130376
44Vibrio cholerae infection_Homo sapiens_hsa051101.00705709
45TGF-beta signaling pathway_Homo sapiens_hsa043500.98262435
46cAMP signaling pathway_Homo sapiens_hsa040240.96273138
47Morphine addiction_Homo sapiens_hsa050320.94479416
48GnRH signaling pathway_Homo sapiens_hsa049120.93151673
49MAPK signaling pathway_Homo sapiens_hsa040100.93144056
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92954245
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90819943
52Tyrosine metabolism_Homo sapiens_hsa003500.90097506
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89781698
54Rap1 signaling pathway_Homo sapiens_hsa040150.89094241
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87388009
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86608337
57Protein digestion and absorption_Homo sapiens_hsa049740.86602944
58Ras signaling pathway_Homo sapiens_hsa040140.86327614
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85020876
60Thyroid hormone synthesis_Homo sapiens_hsa049180.83463710
61ECM-receptor interaction_Homo sapiens_hsa045120.82931677
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80236965
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78505884
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78042688
65Dilated cardiomyopathy_Homo sapiens_hsa054140.77810352
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75961316
67Glioma_Homo sapiens_hsa052140.75697252
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.71471025
69Calcium signaling pathway_Homo sapiens_hsa040200.70187961
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.69776600
71Rheumatoid arthritis_Homo sapiens_hsa053230.69651175
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68837156
73Pancreatic cancer_Homo sapiens_hsa052120.68405641
74Cardiac muscle contraction_Homo sapiens_hsa042600.66831912
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66691869
76Phagosome_Homo sapiens_hsa041450.66478484
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62393339
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57882946
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56368506
80Butanoate metabolism_Homo sapiens_hsa006500.56177594
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55312881
82Estrogen signaling pathway_Homo sapiens_hsa049150.55081010
83Long-term depression_Homo sapiens_hsa047300.54148737
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53840392
85Proteoglycans in cancer_Homo sapiens_hsa052050.53384997
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53027355
87Oxytocin signaling pathway_Homo sapiens_hsa049210.50776206
88Pathways in cancer_Homo sapiens_hsa052000.50018769
89Hepatitis C_Homo sapiens_hsa051600.49570401
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48991104
91Adherens junction_Homo sapiens_hsa045200.48344187
92Thyroid cancer_Homo sapiens_hsa052160.45822400
93Colorectal cancer_Homo sapiens_hsa052100.44448624
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.44116580
95Gap junction_Homo sapiens_hsa045400.43382696
96Hedgehog signaling pathway_Homo sapiens_hsa043400.41169282
97VEGF signaling pathway_Homo sapiens_hsa043700.40454392
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39181177
99Oxidative phosphorylation_Homo sapiens_hsa001900.38921782
100Chemical carcinogenesis_Homo sapiens_hsa052040.37900446

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