GSAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.35918986
2modulation by symbiont of host immune response (GO:0052553)5.13130835
3positive regulation by symbiont of host defense response (GO:0052509)5.13130835
4modulation by symbiont of host defense response (GO:0052031)5.13130835
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.13130835
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.13130835
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.13130835
8neutrophil activation involved in immune response (GO:0002283)4.70565641
9response to peptidoglycan (GO:0032494)4.41527253
10positive regulation of interferon-alpha production (GO:0032727)4.15182028
11hydrogen peroxide biosynthetic process (GO:0050665)3.94928681
12regulation of interferon-alpha production (GO:0032647)3.92162824
13macrophage activation involved in immune response (GO:0002281)3.90677054
14regulation of gamma-delta T cell activation (GO:0046643)3.85397873
15detection of bacterium (GO:0016045)3.83560816
16positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.80519395
17cellular extravasation (GO:0045123)3.74908361
18respiratory burst (GO:0045730)3.66880778
19regulation of interferon-beta biosynthetic process (GO:0045357)3.61757353
20granulocyte activation (GO:0036230)3.58892580
21response to host immune response (GO:0052572)3.58888701
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.58888701
23positive regulation of gamma-delta T cell activation (GO:0046645)3.58184430
24neutrophil activation (GO:0042119)3.55834909
25immunoglobulin mediated immune response (GO:0016064)3.54572172
26detection of molecule of bacterial origin (GO:0032490)3.54102425
27lipopolysaccharide-mediated signaling pathway (GO:0031663)3.50178159
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.48081141
29regulation of mast cell activation (GO:0033003)3.46881728
30microglial cell activation (GO:0001774)3.45972326
31* positive regulation of cellular amide metabolic process (GO:0034250)3.45427346
32reactive oxygen species biosynthetic process (GO:1903409)3.44369770
33positive regulation of chemokine biosynthetic process (GO:0045080)3.42717891
34positive regulation of antigen processing and presentation (GO:0002579)3.41149237
35antigen processing and presentation of endogenous antigen (GO:0019883)3.38307042
36response to muramyl dipeptide (GO:0032495)3.35401606
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.33656114
38B cell receptor signaling pathway (GO:0050853)3.31498176
39type I interferon signaling pathway (GO:0060337)3.29963134
40cellular response to type I interferon (GO:0071357)3.29963134
41response to type I interferon (GO:0034340)3.29722755
42regulation of gamma-delta T cell differentiation (GO:0045586)3.28329708
43antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.23441356
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23441356
45regulation of mast cell activation involved in immune response (GO:0033006)3.22842972
46superoxide anion generation (GO:0042554)3.22377481
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.21768628
48response to host (GO:0075136)3.21768628
49response to host defenses (GO:0052200)3.21768628
50T-helper 1 type immune response (GO:0042088)3.21677679
51macrophage activation (GO:0042116)3.18181937
52regulation of B cell receptor signaling pathway (GO:0050855)3.17154991
53production of molecular mediator involved in inflammatory response (GO:0002532)3.15802412
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.13817077
55positive regulation of humoral immune response (GO:0002922)3.09719490
56positive regulation of heat generation (GO:0031652)3.07264061
57regulation of myeloid leukocyte mediated immunity (GO:0002886)3.06785388
58germinal center formation (GO:0002467)3.06601730
59leukocyte aggregation (GO:0070486)3.01734572
60defense response to protozoan (GO:0042832)3.00526003
61positive regulation of interferon-beta production (GO:0032728)3.00407140
62myeloid cell activation involved in immune response (GO:0002275)3.00010191
63negative regulation of lipid storage (GO:0010888)2.99431460
64regulation of chemokine biosynthetic process (GO:0045073)2.98112855
65positive regulation of B cell differentiation (GO:0045579)2.97843541
66regulation of leukocyte degranulation (GO:0043300)2.96295475
67interferon-gamma-mediated signaling pathway (GO:0060333)2.96192196
68negative regulation of lymphocyte mediated immunity (GO:0002707)2.95955281
69regulation of tolerance induction (GO:0002643)2.94321846
70regulation of interleukin-12 biosynthetic process (GO:0045075)2.93317158
71cellular response to exogenous dsRNA (GO:0071360)2.93279763
72positive regulation of interleukin-12 production (GO:0032735)2.91758960
73regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91618405
74positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.90325770
75cellular response to interferon-beta (GO:0035458)2.89960188
76antigen processing and presentation via MHC class Ib (GO:0002475)2.87588423
77regulation of antigen processing and presentation (GO:0002577)2.86431509
78positive thymic T cell selection (GO:0045059)2.83436977
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83092476
80natural killer cell mediated cytotoxicity (GO:0042267)2.82829672
81natural killer cell mediated immunity (GO:0002228)2.82829672
82detection of external biotic stimulus (GO:0098581)2.82718833
83leukocyte mediated cytotoxicity (GO:0001909)2.80861771
84T cell migration (GO:0072678)2.80404652
85regulation of T-helper 2 cell differentiation (GO:0045628)2.80352554
86negative regulation of T cell mediated immunity (GO:0002710)2.79004648
87regulation of activation of Janus kinase activity (GO:0010533)2.78955994
88regulation of T cell tolerance induction (GO:0002664)2.77947129
89regulation of fever generation (GO:0031620)2.77693324
90positive regulation of type 2 immune response (GO:0002830)2.77594498
91negative regulation of interleukin-17 production (GO:0032700)2.74423880
92negative regulation of leukocyte mediated immunity (GO:0002704)2.73821845
93regulation of B cell differentiation (GO:0045577)2.73337484
94regulation of T-helper 1 cell differentiation (GO:0045625)2.72814233
95positive regulation of toll-like receptor signaling pathway (GO:0034123)2.72511251
96positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.71996765
97negative thymic T cell selection (GO:0045060)2.71599763
98cellular response to ethanol (GO:0071361)2.70099245
99negative regulation of erythrocyte differentiation (GO:0045647)2.69847751
100neutrophil mediated immunity (GO:0002446)2.69457259
101regulation of mononuclear cell migration (GO:0071675)2.69069516
102positive regulation of mast cell activation involved in immune response (GO:0033008)2.69002392
103positive regulation of mast cell degranulation (GO:0043306)2.69002392
104positive regulation of leukocyte degranulation (GO:0043302)2.68471784
105negative regulation of viral genome replication (GO:0045071)2.68213168
106regulation of type 2 immune response (GO:0002828)2.67791733
107detection of other organism (GO:0098543)2.67620603
108positive regulation of mast cell activation (GO:0033005)2.67356993
109myeloid dendritic cell differentiation (GO:0043011)2.67053222
110I-kappaB phosphorylation (GO:0007252)2.66213113
111cytokine secretion (GO:0050663)2.65900965
112detection of biotic stimulus (GO:0009595)2.65440792
113negative regulation of cell killing (GO:0031342)2.65317799
114negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.65317799
115NIK/NF-kappaB signaling (GO:0038061)2.65245821
116regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.65039198
117negative regulation of interleukin-12 production (GO:0032695)2.64746863
118regulation of hypersensitivity (GO:0002883)2.64614108
119response to interferon-alpha (GO:0035455)2.63403999
120response to protozoan (GO:0001562)2.62744544
121positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62291587
122cellular response to thyroid hormone stimulus (GO:0097067)2.62117423
123positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.60706689
124myeloid dendritic cell activation (GO:0001773)2.60196247
125cellular response to interferon-gamma (GO:0071346)2.59939371
126regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.59494178
127positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.59169091
128adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.59060003
129regulation of mast cell degranulation (GO:0043304)2.58975414
130regulation of RIG-I signaling pathway (GO:0039535)2.58706864
131B cell mediated immunity (GO:0019724)2.58506283
132negative regulation of myeloid cell apoptotic process (GO:0033033)2.58478935
133myeloid leukocyte activation (GO:0002274)2.57658792
134negative T cell selection (GO:0043383)2.57488752
135negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.55678310
136negative regulation of T-helper cell differentiation (GO:0045623)2.55678310
137positive regulation of immunoglobulin mediated immune response (GO:0002891)2.55372635
138positive regulation of B cell mediated immunity (GO:0002714)2.55372635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.50747621
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.94884396
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.35062011
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.18557197
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.95319816
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.89733046
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71595483
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.66500576
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.48881228
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18241328
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.18144251
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.11901868
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.88539435
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78476470
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.78378155
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62208776
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.51457332
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37191537
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.25303792
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.24738751
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18694918
22PPARA_22158963_ChIP-Seq_LIVER_Mouse2.12698292
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.11354286
24RUNX_20019798_ChIP-Seq_JUKART_Human1.92441754
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88452635
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.82091892
27SCL_19346495_ChIP-Seq_HPC-7_Human1.76736213
28GATA1_22025678_ChIP-Seq_K562_Human1.76037523
29PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66229299
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66144311
31VDR_24787735_ChIP-Seq_THP-1_Human1.65421636
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64562044
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63623915
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63344287
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63143681
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.63092985
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56859649
38SPI1_23547873_ChIP-Seq_NB4_Human1.55006717
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.54741088
40PU_27001747_Chip-Seq_BMDM_Mouse1.50895143
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50292987
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49087439
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47993819
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46054857
45MYB_26560356_Chip-Seq_TH2_Human1.42239254
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.35992708
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33565235
48SPI1_23127762_ChIP-Seq_K562_Human1.29175400
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25593396
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24223869
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23477110
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22583781
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21442350
54VDR_24763502_ChIP-Seq_THP-1_Human1.21284737
55GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20831268
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20655102
57UTX_26944678_Chip-Seq_JUKART_Human1.20629998
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.18406989
59VDR_21846776_ChIP-Seq_THP-1_Human1.17313248
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16848108
61MYB_26560356_Chip-Seq_TH1_Human1.16194876
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15629349
63CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11525621
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10744638
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09636872
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09533411
67TCF7_22412390_ChIP-Seq_EML_Mouse1.09473618
68GATA3_26560356_Chip-Seq_TH2_Human1.09015731
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07952949
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07952949
71MAF_26560356_Chip-Seq_TH1_Human1.07484975
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04710301
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01893413
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00329912
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00177361
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99638820
77GATA3_27048872_Chip-Seq_THYMUS_Human0.99622490
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99470728
79SMRT_27268052_Chip-Seq_Bcells_Human0.96166498
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94328346
81MYC_22102868_ChIP-Seq_BL_Human0.94174249
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90842508
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90031659
84GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88782950
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88161691
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87688199
87MAF_26560356_Chip-Seq_TH2_Human0.87237434
88GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86851830
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86317207
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86277232
91SOX2_20726797_ChIP-Seq_SW620_Human0.84502696
92GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83236755
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81877899
94EGR1_19032775_ChIP-ChIP_M12_Human0.81749466
95FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80152251
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78545507
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.76889892
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75365458
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75232800
100STAT1_20625510_ChIP-Seq_HELA_Human0.74607636
101GATA2_19941826_ChIP-Seq_K562_Human0.73870104
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.73140945
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73136443
104FOXO3_23340844_ChIP-Seq_DLD1_Human0.72650896
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.72594697
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71236398
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.70873662
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.70764077
109PU1_27457419_Chip-Seq_LIVER_Mouse0.68108888
110EZH2_27294783_Chip-Seq_NPCs_Mouse0.67858249
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67737302
112KDM2B_26808549_Chip-Seq_DND41_Human0.66804930
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.65946661
114CJUN_26792858_Chip-Seq_BT549_Human0.65716294
115JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65609566
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.64869706
117NFE2_27457419_Chip-Seq_LIVER_Mouse0.64567658
118JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63532914
119CDX2_20551321_ChIP-Seq_CACO-2_Human0.63468337
120GATA1_19941826_ChIP-Seq_K562_Human0.63190290
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.61551927
122BCL6_27268052_Chip-Seq_Bcells_Human0.61410841
123IKZF1_21737484_ChIP-ChIP_HCT116_Human0.60124473

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.48934130
2MP0009785_altered_susceptibility_to3.56647042
3MP0003436_decreased_susceptibility_to3.39880266
4MP0002148_abnormal_hypersensitivity_rea3.07348679
5MP0006082_CNS_inflammation3.03689277
6MP0002419_abnormal_innate_immunity2.95203870
7MP0003724_increased_susceptibility_to2.85319249
8MP0000685_abnormal_immune_system2.78343828
9MP0005025_abnormal_response_to2.77345132
10MP0005387_immune_system_phenotype2.76349008
11MP0001790_abnormal_immune_system2.76349008
12MP0005000_abnormal_immune_tolerance2.71411173
13MP0002139_abnormal_hepatobiliary_system2.59467352
14MP0005671_abnormal_response_to2.48571128
15MP0002452_abnormal_antigen_presenting2.36648627
16MP0003191_abnormal_cellular_cholesterol2.34640816
17MP0001800_abnormal_humoral_immune2.28816955
18MP0002723_abnormal_immune_serum2.27622480
19MP0005058_abnormal_lysosome_morphology2.26695190
20MP0004782_abnormal_surfactant_physiolog2.20998213
21MP0009764_decreased_sensitivity_to2.20025341
22MP0009840_abnormal_foam_cell2.18400860
23MP0004510_myositis2.12597306
24MP0003303_peritoneal_inflammation2.11746076
25MP0005464_abnormal_platelet_physiology2.08455470
26MP0005360_urolithiasis1.99548495
27MP0001819_abnormal_immune_cell1.99276800
28MP0001853_heart_inflammation1.97940044
29MP0002420_abnormal_adaptive_immunity1.95694601
30MP0002138_abnormal_hepatobiliary_system1.88336901
31MP0005085_abnormal_gallbladder_physiolo1.82380063
32MP0008469_abnormal_protein_level1.80827909
33MP0003172_abnormal_lysosome_physiology1.75540140
34MP0001845_abnormal_inflammatory_respons1.73932536
35MP0002405_respiratory_system_inflammati1.72897973
36MP0005365_abnormal_bile_salt1.71527286
37MP0000569_abnormal_digit_pigmentation1.68668769
38MP0001533_abnormal_skeleton_physiology1.68658886
39MP0004947_skin_inflammation1.67127195
40MP0002006_tumorigenesis1.54400607
41MP0002254_reproductive_system_inflammat1.50020050
42MP0008004_abnormal_stomach_pH1.49140855
43MP0005083_abnormal_biliary_tract1.46938227
44MP0010155_abnormal_intestine_physiology1.45427492
45MP0003075_altered_response_to1.44079077
46MP0003195_calcinosis1.43035316
47MP0000716_abnormal_immune_system1.40561716
48MP0003252_abnormal_bile_duct1.40370113
49MP0003828_pulmonary_edema1.38936136
50MP0000465_gastrointestinal_hemorrhage1.37050043
51MP0008875_abnormal_xenobiotic_pharmacok1.35338548
52MP0003448_altered_tumor_morphology1.34454383
53MP0003183_abnormal_peptide_metabolism1.31502695
54MP0002998_abnormal_bone_remodeling1.30138369
55MP0005167_abnormal_blood-brain_barrier1.29026397
56MP0004883_abnormal_blood_vessel1.28040714
57MP0002166_altered_tumor_susceptibility1.27320307
58MP0005166_decreased_susceptibility_to1.25458895
59MP0002398_abnormal_bone_marrow1.23372891
60MP0003690_abnormal_glial_cell1.21895757
61MP0005310_abnormal_salivary_gland1.20020187
62MP0000343_altered_response_to1.18513422
63MP0003186_abnormal_redox_activity1.17973300
64MP0009763_increased_sensitivity_to1.16745532
65MP0000604_amyloidosis1.16152820
66MP0000858_altered_metastatic_potential1.15592625
67MP0010329_abnormal_lipoprotein_level1.14007426
68MP0003300_gastrointestinal_ulcer1.08907949
69MP0000689_abnormal_spleen_morphology1.08773398
70MP0003866_abnormal_defecation1.08552103
71MP0002429_abnormal_blood_cell1.07027122
72MP0000609_abnormal_liver_physiology1.06562814
73MP0002277_abnormal_respiratory_mucosa1.05859282
74MP0009333_abnormal_splenocyte_physiolog1.05699997
75MP0009278_abnormal_bone_marrow1.03570711
76MP0003763_abnormal_thymus_physiology0.97908319
77MP0001545_abnormal_hematopoietic_system0.96647291
78MP0005397_hematopoietic_system_phenotyp0.96647291
79MP0005451_abnormal_body_composition0.95099863
80MP0002722_abnormal_immune_system0.92473839
81MP0005164_abnormal_response_to0.89991574
82MP0005319_abnormal_enzyme/_coenzyme0.89756817
83MP0008260_abnormal_autophagy0.88207155
84MP0001873_stomach_inflammation0.86792259
85MP0009697_abnormal_copulation0.84920574
86MP0001958_emphysema0.84417291
87MP0004019_abnormal_vitamin_homeostasis0.82798423
88MP0001851_eye_inflammation0.82676017
89MP0001663_abnormal_digestive_system0.82433725
90MP0000703_abnormal_thymus_morphology0.82395418
91MP0005174_abnormal_tail_pigmentation0.81335143
92MP0003091_abnormal_cell_migration0.78940801
93MP0000249_abnormal_blood_vessel0.78300292
94MP0006054_spinal_hemorrhage0.77338688
95MP0002118_abnormal_lipid_homeostasis0.76260008
96MP0003045_fibrosis0.75510442
97MP0004381_abnormal_hair_follicle0.75397842
98MP0005584_abnormal_enzyme/coenzyme_acti0.75147800
99MP0002332_abnormal_exercise_endurance0.74634676
100MP0002132_abnormal_respiratory_system0.74471897
101MP0002933_joint_inflammation0.73574865
102MP0000371_diluted_coat_color0.73342969
103MP0001666_abnormal_nutrient_absorption0.73090876
104MP0002136_abnormal_kidney_physiology0.73066843
105MP0003806_abnormal_nucleotide_metabolis0.70994528
106MP0005332_abnormal_amino_acid0.70185403
107MP0000015_abnormal_ear_pigmentation0.70005523
108MP0005390_skeleton_phenotype0.69830474
109MP0004808_abnormal_hematopoietic_stem0.68756196
110MP0000920_abnormal_myelination0.67393465
111MP0002396_abnormal_hematopoietic_system0.65745665
112MP0003795_abnormal_bone_structure0.65106718
113MP0003453_abnormal_keratinocyte_physiol0.63958839
114MP0009765_abnormal_xenobiotic_induced0.63792956
115MP0001764_abnormal_homeostasis0.63759280
116MP0003656_abnormal_erythrocyte_physiolo0.63152619
117MP0002693_abnormal_pancreas_physiology0.63073436
118MP0002928_abnormal_bile_duct0.62568143
119MP0000598_abnormal_liver_morphology0.62308539
120MP0005075_abnormal_melanosome_morpholog0.61888003
121MP0008874_decreased_physiological_sensi0.56807847

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.31001931
2Recurrent gram-negative bacterial infections (HP:0005420)6.10626837
3Eczematoid dermatitis (HP:0000976)6.05071062
4Recurrent bacterial skin infections (HP:0005406)6.00925593
5Abnormality of macrophages (HP:0004311)4.56628847
6Mediastinal lymphadenopathy (HP:0100721)4.51445246
7Autoimmune thrombocytopenia (HP:0001973)4.05358108
8Recurrent skin infections (HP:0001581)4.04259649
9Joint hemorrhage (HP:0005261)3.95364118
10Systemic lupus erythematosus (HP:0002725)3.95353071
11Elevated erythrocyte sedimentation rate (HP:0003565)3.84744930
12Gingivitis (HP:0000230)3.75380017
13Myositis (HP:0100614)3.66154033
14Orchitis (HP:0100796)3.61837236
15Stomatitis (HP:0010280)3.60356837
16Recurrent fungal infections (HP:0002841)3.55725050
17Vacuolated lymphocytes (HP:0001922)3.55306707
18Retrobulbar optic neuritis (HP:0100654)3.53955618
19Optic neuritis (HP:0100653)3.53955618
20Interstitial pulmonary disease (HP:0006530)3.47048669
21Vasculitis (HP:0002633)3.27287228
22Prolonged partial thromboplastin time (HP:0003645)3.17759050
23Gingival bleeding (HP:0000225)3.15654926
24Periodontitis (HP:0000704)3.13017876
25Myocardial infarction (HP:0001658)3.09580175
26Chronic obstructive pulmonary disease (HP:0006510)3.01050555
27Obstructive lung disease (HP:0006536)3.01050555
28Increased IgM level (HP:0003496)2.99789719
29Recurrent cutaneous fungal infections (HP:0011370)2.99602316
30Chronic mucocutaneous candidiasis (HP:0002728)2.99602316
31Increased neuronal autofluorescent lipopigment (HP:0002074)2.98580605
32Recurrent viral infections (HP:0004429)2.98522151
33Glomerulonephritis (HP:0000099)2.94029905
34Encephalitis (HP:0002383)2.93512461
35Increased cerebral lipofuscin (HP:0011813)2.90290943
36Petechiae (HP:0000967)2.87410386
37Pulmonary infiltrates (HP:0002113)2.76883074
38Complement deficiency (HP:0004431)2.76018187
39Basal ganglia calcification (HP:0002135)2.75824482
40Urticaria (HP:0001025)2.71815679
41Tetraparesis (HP:0002273)2.68684485
42Chronic otitis media (HP:0000389)2.65502998
43Pustule (HP:0200039)2.64126430
44Gastrointestinal inflammation (HP:0004386)2.60923138
45Meningitis (HP:0001287)2.59544522
46Axonal loss (HP:0003447)2.59415901
47Chest pain (HP:0100749)2.55193740
48Thick nail (HP:0001805)2.54026872
49Increased CSF protein (HP:0002922)2.53030957
50Prostate neoplasm (HP:0100787)2.52002490
51Loss of speech (HP:0002371)2.50757317
52Joint swelling (HP:0001386)2.48224682
53Urinary glycosaminoglycan excretion (HP:0003541)2.47885477
54Mucopolysacchariduria (HP:0008155)2.47885477
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.47508698
56Abnormality of polysaccharide metabolism (HP:0011012)2.47508698
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.47508698
58Arterial thrombosis (HP:0004420)2.47217464
59Abnormality of complement system (HP:0005339)2.41678676
60Recurrent pneumonia (HP:0006532)2.39003571
61Epistaxis (HP:0000421)2.38704884
62Xanthomatosis (HP:0000991)2.34851644
63Abnormality of T cell number (HP:0011839)2.34454080
64Abnormality of the common coagulation pathway (HP:0010990)2.34176347
65Increased serum ferritin (HP:0003281)2.33203486
66Gangrene (HP:0100758)2.32928205
67Osteomyelitis (HP:0002754)2.32429268
68Panhypogammaglobulinemia (HP:0003139)2.32249121
69Hemoptysis (HP:0002105)2.30122176
70Nephritis (HP:0000123)2.28791061
71Intrahepatic cholestasis (HP:0001406)2.28712981
72Amyloidosis (HP:0011034)2.27292500
73Abnormal platelet volume (HP:0011876)2.26729185
74Leukocytosis (HP:0001974)2.25724762
75Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.24847184
76Deep venous thrombosis (HP:0002625)2.22774716
77Episodic fever (HP:0001954)2.22453745
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.20763249
79Keratoconjunctivitis sicca (HP:0001097)2.20052177
80Menorrhagia (HP:0000132)2.19782098
81Polyneuropathy (HP:0001271)2.19004003
82Abnormality of aromatic amino acid family metabolism (HP:0004338)2.18417719
83Abnormality of iron homeostasis (HP:0011031)2.18021035
84Esophageal varix (HP:0002040)2.16884788
85Cellulitis (HP:0100658)2.16799684
86Gastrointestinal infarctions (HP:0005244)2.15842378
87Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15765782
88Increased IgE level (HP:0003212)2.13990546
89Agammaglobulinemia (HP:0004432)2.10344927
90Hypergammaglobulinemia (HP:0010702)2.10194256
91Anorexia (HP:0002039)2.09557591
92Spontaneous hematomas (HP:0007420)2.08961198
93T lymphocytopenia (HP:0005403)2.08922479
94Vertigo (HP:0002321)2.08823030
95Abnormality of glutamine family amino acid metabolism (HP:0010902)2.08374642
96Colitis (HP:0002583)2.07969647
97Granulocytopenia (HP:0001913)2.07873301
98Abnormality of the pleura (HP:0002103)2.07540656
99Bone pain (HP:0002653)2.07104572
100Hematochezia (HP:0002573)2.06584493
101Abnormality of the vasculature of the conjunctiva (HP:0008054)2.06158018
102Dysostosis multiplex (HP:0000943)2.03814541
103Abnormality of the prostate (HP:0008775)2.03042864
104Hyperlipoproteinemia (HP:0010980)2.02604182
105Disinhibition (HP:0000734)2.02581673
106Abnormality of liposaccharide metabolism (HP:0010968)2.02485409
107Abnormality of glycosphingolipid metabolism (HP:0004343)2.02485409
108Abnormality of glycolipid metabolism (HP:0010969)2.02485409
109Eosinophilia (HP:0001880)2.02185588
110Recurrent bronchitis (HP:0002837)2.01927516
111Prolonged bleeding time (HP:0003010)2.01284232
112Recurrent lower respiratory tract infections (HP:0002783)2.00067034
113Cheilitis (HP:0100825)2.00039246
114Hypercholesterolemia (HP:0003124)1.99812788
115Keratoconjunctivitis (HP:0001096)1.99421968
116Pulmonary embolism (HP:0002204)1.98194689
117Hepatosplenomegaly (HP:0001433)1.98165401
118Restrictive lung disease (HP:0002091)1.97273507
119Abnormality of pyrimidine metabolism (HP:0004353)1.96738085
120Chronic diarrhea (HP:0002028)1.96698467
121Inflammation of the large intestine (HP:0002037)1.95378266
122Thrombophlebitis (HP:0004418)1.94216094
123Mitral stenosis (HP:0001718)1.93900219
124Abnormality of transition element cation homeostasis (HP:0011030)1.93185297
125Conjugated hyperbilirubinemia (HP:0002908)1.93008828
126Increased mean platelet volume (HP:0011877)1.92217537
127Gastrointestinal stroma tumor (HP:0100723)1.91634573
128Epidermoid cyst (HP:0200040)1.91200678
129Purpura (HP:0000979)1.91174717
130Pathologic fracture (HP:0002756)1.90698382
131Premature loss of primary teeth (HP:0006323)1.89650042
132Prolonged neonatal jaundice (HP:0006579)1.88742641
133Abnormality of T cells (HP:0002843)1.86160504

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.88748455
2IRAK33.36895173
3TBK13.31975689
4TYK23.30641367
5RIPK43.26110826
6IRAK43.22994766
7IKBKE3.07458314
8TXK2.81219332
9BLK2.76690020
10JAK32.53734289
11MAP4K12.43113680
12IKBKB2.38151525
13JAK12.30878994
14KIT2.05020895
15MAP3K131.96608223
16TAOK31.96022653
17PBK1.83731617
18CSK1.75873516
19CHUK1.72477958
20GRK61.69965995
21ERN11.67561398
22ZAP701.66597892
23FGFR41.63592100
24TGFBR21.54101985
25TNK21.47336908
26NEK91.46592392
27PRPF4B1.40846129
28BMPR21.39521103
29TEC1.35482391
30BTK1.28502161
31CSF1R1.25897167
32SYK1.24230256
33HCK1.23727303
34LYN1.18098353
35EPHB11.13104008
36CDC42BPA1.11632051
37IRAK11.08942709
38SIK31.08921498
39LCK1.08731676
40FGFR31.08292671
41JAK21.07616960
42EIF2AK21.07593803
43FRK1.06818680
44ACVR1B1.00190552
45MAP3K10.98735180
46MARK30.97129736
47RIPK10.96343267
48FGR0.95929528
49INSRR0.95004931
50SIK10.94834497
51TGFBR10.91399774
52PIM10.90619785
53CAMKK20.89172308
54PDK10.88237487
55ITK0.87908696
56RPS6KA40.87492871
57PIM20.86013230
58YES10.85624955
59MAP2K60.84607102
60EPHA30.80415194
61CDK80.79885034
62GRK70.78926142
63MST1R0.76713478
64DAPK20.76054741
65NLK0.74861683
66IRAK20.74571902
67ABL20.74386101
68ERBB30.73526055
69STK100.73277482
70STK240.72955217
71TAOK10.70376598
72MAP3K20.69041807
73PRKCD0.69008986
74MAP3K110.67888075
75PIK3CG0.67826614
76PRKCQ0.67567110
77MST40.67559781
78FLT30.66850963
79BMPR1B0.66039287
80ABL10.63156215
81ERBB40.62593311
82CDK90.62509503
83STK40.62178866
84MAP2K30.62150613
85MATK0.62112643
86EGFR0.60992381
87MAP3K70.59969008
88FES0.59941894
89MAPK120.59552860
90ADRBK20.57048333
91HIPK20.55761007
92BMX0.55013126
93TAOK20.54159654
94CDK60.54062377
95MAPK70.53194833
96CLK10.52987376
97TIE10.52882117
98PTK60.52308264
99TRPM70.51958366
100PTK2B0.50439251
101MAP3K120.49385432
102IGF1R0.49140173
103MARK20.47891078
104NUAK10.47766919
105SGK30.43526766
106STK30.42235088
107CAMK1D0.40333844
108SIK20.39662435
109GRK10.39254415
110MOS0.37557214
111MUSK0.37062297
112MAP3K50.36763337
113MAPK110.36392232
114MAP3K30.36353067
115NME20.35519589
116KSR20.34843609
117MAPKAPK20.34782296
118SGK20.34367028
119PKN10.32936909
120PRKG20.31965698
121STK380.31884582
122PRKD20.30470708
123RET0.29931285
124PRKAA20.29726898
125PDGFRB0.26542028
126RPS6KA60.26521645
127FYN0.26155134
128PIK3CA0.23531738
129MAPK40.22797212
130PDPK10.22462418
131KDR0.22298105

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.48908920
2Graft-versus-host disease_Homo sapiens_hsa053323.27090555
3Leishmaniasis_Homo sapiens_hsa051402.87737277
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.56447999
5Allograft rejection_Homo sapiens_hsa053302.51982112
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.49886025
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.28527518
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.17990949
9Malaria_Homo sapiens_hsa051442.11268097
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.09240953
11Complement and coagulation cascades_Homo sapiens_hsa046102.07263443
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.06445148
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.06220307
14Legionellosis_Homo sapiens_hsa051342.02548173
15Osteoclast differentiation_Homo sapiens_hsa043802.00412505
16Measles_Homo sapiens_hsa051621.95274806
17Pertussis_Homo sapiens_hsa051331.94315634
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.88951274
19Rheumatoid arthritis_Homo sapiens_hsa053231.88186242
20Tuberculosis_Homo sapiens_hsa051521.75650133
21TNF signaling pathway_Homo sapiens_hsa046681.65118194
22Type I diabetes mellitus_Homo sapiens_hsa049401.61352210
23Influenza A_Homo sapiens_hsa051641.60164861
24African trypanosomiasis_Homo sapiens_hsa051431.56643347
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53577522
26Asthma_Homo sapiens_hsa053101.49532257
27Lysosome_Homo sapiens_hsa041421.47225070
28Caffeine metabolism_Homo sapiens_hsa002321.46741236
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.43728221
30Hematopoietic cell lineage_Homo sapiens_hsa046401.39377489
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32096281
32Herpes simplex infection_Homo sapiens_hsa051681.30941347
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30600585
34B cell receptor signaling pathway_Homo sapiens_hsa046621.28703617
35Phagosome_Homo sapiens_hsa041451.24466083
36Autoimmune thyroid disease_Homo sapiens_hsa053201.22567435
37Salmonella infection_Homo sapiens_hsa051321.20828857
38Toxoplasmosis_Homo sapiens_hsa051451.20497423
39Primary immunodeficiency_Homo sapiens_hsa053401.19332958
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17584486
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16866820
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15660839
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.14759489
44Antigen processing and presentation_Homo sapiens_hsa046121.10536876
45Peroxisome_Homo sapiens_hsa041461.06107034
46Dorso-ventral axis formation_Homo sapiens_hsa043201.04571827
47Chemokine signaling pathway_Homo sapiens_hsa040621.04517493
48Tryptophan metabolism_Homo sapiens_hsa003801.03071764
49Other glycan degradation_Homo sapiens_hsa005111.02716930
50Apoptosis_Homo sapiens_hsa042101.02523464
51Arginine biosynthesis_Homo sapiens_hsa002201.01501140
52ABC transporters_Homo sapiens_hsa020101.00744988
53Histidine metabolism_Homo sapiens_hsa003400.95979913
54Hepatitis C_Homo sapiens_hsa051600.95513229
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.94027444
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.85198304
57Shigellosis_Homo sapiens_hsa051310.82781200
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82467561
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81847060
60Steroid biosynthesis_Homo sapiens_hsa001000.79004788
61Chemical carcinogenesis_Homo sapiens_hsa052040.78792082
62Nitrogen metabolism_Homo sapiens_hsa009100.78520527
63PPAR signaling pathway_Homo sapiens_hsa033200.75746125
64Hepatitis B_Homo sapiens_hsa051610.75390346
65Retinol metabolism_Homo sapiens_hsa008300.74840947
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73090449
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71417336
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70554531
69Viral myocarditis_Homo sapiens_hsa054160.70469367
70T cell receptor signaling pathway_Homo sapiens_hsa046600.70158079
71Fatty acid degradation_Homo sapiens_hsa000710.69287381
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68066436
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65930792
74Prion diseases_Homo sapiens_hsa050200.65595366
75Non-small cell lung cancer_Homo sapiens_hsa052230.58859859
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57583263
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57130240
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.57098874
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.56052297
80Amoebiasis_Homo sapiens_hsa051460.55552924
81Starch and sucrose metabolism_Homo sapiens_hsa005000.54344632
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.54207002
83beta-Alanine metabolism_Homo sapiens_hsa004100.53935610
84Arachidonic acid metabolism_Homo sapiens_hsa005900.51445635
85VEGF signaling pathway_Homo sapiens_hsa043700.49495523
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.49414891
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49408448
88Acute myeloid leukemia_Homo sapiens_hsa052210.48943807
89Type II diabetes mellitus_Homo sapiens_hsa049300.47392085
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47315120
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45716271
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44290254
93Systemic lupus erythematosus_Homo sapiens_hsa053220.43966186
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43360271
95Collecting duct acid secretion_Homo sapiens_hsa049660.42631301
96Mineral absorption_Homo sapiens_hsa049780.41899647
97Phenylalanine metabolism_Homo sapiens_hsa003600.41223539
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.40485870
99Prolactin signaling pathway_Homo sapiens_hsa049170.39537663
100Epstein-Barr virus infection_Homo sapiens_hsa051690.39530595
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38937438
102Vitamin digestion and absorption_Homo sapiens_hsa049770.37376542
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36512636
104Endocytosis_Homo sapiens_hsa041440.34593995
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.34545259
106mTOR signaling pathway_Homo sapiens_hsa041500.34401324
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33979063
108Fatty acid metabolism_Homo sapiens_hsa012120.33443529
109Renal cell carcinoma_Homo sapiens_hsa052110.32562125
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.32192626
111Selenocompound metabolism_Homo sapiens_hsa004500.32008646
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31922480
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31417880
114Choline metabolism in cancer_Homo sapiens_hsa052310.30634626
115Ether lipid metabolism_Homo sapiens_hsa005650.29742653
116HTLV-I infection_Homo sapiens_hsa051660.29547733
117GnRH signaling pathway_Homo sapiens_hsa049120.28038345
118Bile secretion_Homo sapiens_hsa049760.27943235
119FoxO signaling pathway_Homo sapiens_hsa040680.27445477
120Insulin resistance_Homo sapiens_hsa049310.27170028
121Chronic myeloid leukemia_Homo sapiens_hsa052200.25657274
122Inositol phosphate metabolism_Homo sapiens_hsa005620.25084472
123HIF-1 signaling pathway_Homo sapiens_hsa040660.24567444
124Pancreatic cancer_Homo sapiens_hsa052120.24499229
125Platelet activation_Homo sapiens_hsa046110.24284175
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23915267
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22718981
128Sphingolipid metabolism_Homo sapiens_hsa006000.22506405
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.22119432
130Fatty acid biosynthesis_Homo sapiens_hsa000610.22099531
131MAPK signaling pathway_Homo sapiens_hsa040100.21731071
132Regulation of autophagy_Homo sapiens_hsa041400.20448577

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