GSC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)9.32979379
2regulation of retinoic acid receptor signaling pathway (GO:0048385)7.77615568
3aminoglycoside antibiotic metabolic process (GO:0030647)7.37651356
4somite rostral/caudal axis specification (GO:0032525)7.09077292
5maintenance of protein location in nucleus (GO:0051457)6.82673785
6negative regulation of epidermis development (GO:0045683)6.82023252
7regulation of mammary gland epithelial cell proliferation (GO:0033599)6.64931186
8regulation of response to osmotic stress (GO:0047484)6.62856032
9negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.35064928
10vitamin catabolic process (GO:0009111)6.33666311
11fat-soluble vitamin catabolic process (GO:0042363)6.33666311
12protein localization to kinetochore (GO:0034501)6.11488220
13regulation of mesoderm development (GO:2000380)5.99870410
14negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.90275137
15regulation of nuclear cell cycle DNA replication (GO:0033262)5.89714400
16outflow tract septum morphogenesis (GO:0003148)5.73045465
17negative regulation of cell cycle G2/M phase transition (GO:1902750)5.71683108
18regulation of telomere maintenance via telomerase (GO:0032210)5.64751484
19histone H4-K8 acetylation (GO:0043982)5.53882919
20histone H4-K5 acetylation (GO:0043981)5.53882919
21regulation of MHC class I biosynthetic process (GO:0045343)5.52742315
22negative regulation of telomerase activity (GO:0051974)5.50090850
23histone H4-K12 acetylation (GO:0043983)5.45613191
24rRNA transcription (GO:0009303)5.44591386
25regulation of cardioblast differentiation (GO:0051890)5.39950793
26prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.26934202
27negative regulation of epidermal cell differentiation (GO:0045605)5.25638751
28outer ear morphogenesis (GO:0042473)5.24914041
29cytidine metabolic process (GO:0046087)5.06155455
30cytidine catabolic process (GO:0006216)5.06155455
31cytidine deamination (GO:0009972)5.06155455
32notochord development (GO:0030903)5.05027610
33regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.01542324
34* dorsal/ventral neural tube patterning (GO:0021904)4.95607903
35type B pancreatic cell development (GO:0003323)4.94171385
36regulation of cilium movement (GO:0003352)4.90876112
37mitotic sister chromatid segregation (GO:0000070)4.90083507
38rRNA methylation (GO:0031167)4.89753528
39phenol-containing compound catabolic process (GO:0019336)4.89115447
40primitive streak formation (GO:0090009)4.84285867
41heterochromatin organization (GO:0070828)4.81908293
42hormone catabolic process (GO:0042447)4.79702539
43interferon-gamma production (GO:0032609)4.62219636
44rRNA modification (GO:0000154)4.57656266
45response to dietary excess (GO:0002021)4.57354800
46protein localization to chromosome, centromeric region (GO:0071459)4.45880831
47positive regulation of DNA-dependent DNA replication (GO:2000105)4.45139908
48negative regulation of activin receptor signaling pathway (GO:0032926)4.44580811
49regulation of Wnt signaling pathway involved in heart development (GO:0003307)4.39966444
50tooth mineralization (GO:0034505)4.35381395
51endoderm formation (GO:0001706)4.35028729
52muscle cell fate commitment (GO:0042693)4.33215730
53branching involved in mammary gland duct morphogenesis (GO:0060444)4.31938592
54adrenergic receptor signaling pathway (GO:0071875)4.28242711
55DNA replication-dependent nucleosome assembly (GO:0006335)4.26346670
56DNA replication-dependent nucleosome organization (GO:0034723)4.26346670
57regulation of apoptotic process involved in morphogenesis (GO:1902337)4.25517246
58quinone metabolic process (GO:1901661)4.23188395
59nucleoside transmembrane transport (GO:1901642)4.22852750
60coenzyme catabolic process (GO:0009109)4.21654818
61regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.17388626
62DNA replication checkpoint (GO:0000076)4.13570810
63chromatin assembly (GO:0031497)4.11280783
64histone H4-K16 acetylation (GO:0043984)4.08126482
65negative regulation of telomere maintenance (GO:0032205)4.08100638
66regulation of translation in response to stress (GO:0043555)4.04148706
67sister chromatid segregation (GO:0000819)4.03175378
68epoxygenase P450 pathway (GO:0019373)3.91038799
69peripheral nervous system neuron development (GO:0048935)3.89408802
70cell migration involved in gastrulation (GO:0042074)3.89016603
71nuclear pore complex assembly (GO:0051292)3.87364278
72glandular epithelial cell development (GO:0002068)3.86808066
73cell fate commitment involved in formation of primary germ layer (GO:0060795)3.82352019
74positive regulation of gastrulation (GO:2000543)3.80972537
75maintenance of protein localization in organelle (GO:0072595)3.76880367
76negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.75116619
77cellular modified amino acid catabolic process (GO:0042219)3.70766120
78bone trabecula formation (GO:0060346)3.70473795
79atrioventricular valve morphogenesis (GO:0003181)3.68626366
80SMAD protein signal transduction (GO:0060395)3.68548485
81positive regulation of skeletal muscle tissue development (GO:0048643)3.68036754
82regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.66197945
83anterior/posterior axis specification, embryo (GO:0008595)3.63209860
84intestinal epithelial cell development (GO:0060576)3.62912738
85neuron fate determination (GO:0048664)3.62304025
86epithelial cell fate commitment (GO:0072148)3.60368773
87negative regulation of cell fate specification (GO:0009996)3.55976818
88atrial septum morphogenesis (GO:0060413)3.54462975
89microtubule severing (GO:0051013)3.53274205
90cullin deneddylation (GO:0010388)3.53201077
91nodal signaling pathway (GO:0038092)3.52847120
92icosanoid secretion (GO:0032309)3.52830567
93arachidonic acid secretion (GO:0050482)3.52830567
94pyrimidine ribonucleoside catabolic process (GO:0046133)3.52601062
95mitochondrion distribution (GO:0048311)3.51195136
96intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.50306162
97proximal/distal pattern formation (GO:0009954)3.49891604
98pre-miRNA processing (GO:0031054)3.49193750
99retinoic acid receptor signaling pathway (GO:0048384)3.47288381
100vitamin A metabolic process (GO:0006776)3.46932860
101trophectodermal cell differentiation (GO:0001829)3.43867486
102DNA damage response, detection of DNA damage (GO:0042769)3.42799065
103omega-hydroxylase P450 pathway (GO:0097267)3.41764324
104cardiovascular system development (GO:0072358)3.40829669
105regulation of telomerase activity (GO:0051972)3.40157685
106positive regulation of protein deacetylation (GO:0090312)3.38346105
107regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.38022933
108nuclear pore organization (GO:0006999)3.37325809
109mammary gland epithelial cell differentiation (GO:0060644)3.37128827
110proline transport (GO:0015824)3.37116028
111embryonic foregut morphogenesis (GO:0048617)3.36941382
112GDP-mannose metabolic process (GO:0019673)3.36598032
113embryonic skeletal joint morphogenesis (GO:0060272)3.36042243
114anterior/posterior axis specification (GO:0009948)3.34682590
115regulation of stem cell maintenance (GO:2000036)3.34517827
116regulation of activin receptor signaling pathway (GO:0032925)3.33910189
117transcription from mitochondrial promoter (GO:0006390)3.33693729
118protein polyglutamylation (GO:0018095)3.33578790
119intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.32067234
120* signal transduction involved in regulation of gene expression (GO:0023019)3.30450112
121positive regulation of urine volume (GO:0035810)3.28970509
122regulation of telomere maintenance (GO:0032204)3.28348686
123cardiocyte differentiation (GO:0035051)3.26703261
124tachykinin receptor signaling pathway (GO:0007217)3.26472164
125negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.25358466
126ribosome biogenesis (GO:0042254)3.24455119
127ventricular system development (GO:0021591)3.23818905
128RNA stabilization (GO:0043489)3.23567701
129mRNA stabilization (GO:0048255)3.23567701
130transepithelial transport (GO:0070633)3.23158897
131regulation of gastrulation (GO:0010470)3.20728798
132regulation of glucocorticoid metabolic process (GO:0031943)3.16420709
133negative regulation of interleukin-2 production (GO:0032703)3.15136225
134maternal placenta development (GO:0001893)3.15058292
135apoptotic DNA fragmentation (GO:0006309)3.14779522
136cellular response to BMP stimulus (GO:0071773)3.14289124
137response to BMP (GO:0071772)3.14289124
138nucleoside transport (GO:0015858)3.11606185
139pharyngeal system development (GO:0060037)3.11291722
140branching involved in prostate gland morphogenesis (GO:0060442)3.10691511
141cofactor transport (GO:0051181)3.10643799
142regulation of gene silencing by RNA (GO:0060966)3.10488350
143regulation of gene silencing by miRNA (GO:0060964)3.10488350
144skeletal muscle tissue regeneration (GO:0043403)3.08803193
145embryonic heart tube development (GO:0035050)3.07727056
146embryonic camera-type eye development (GO:0031076)3.06492845
147kinetochore assembly (GO:0051382)3.04033148
148negative regulation of androgen receptor signaling pathway (GO:0060766)3.00723372
149cardiac septum morphogenesis (GO:0060411)2.97916055
150embryonic viscerocranium morphogenesis (GO:0048703)2.97564605
151neuron fate specification (GO:0048665)2.94933071
152sequestering of extracellular ligand from receptor (GO:0035581)2.94510536
153positive regulation of striated muscle tissue development (GO:0045844)2.88277577
154positive regulation of muscle organ development (GO:0048636)2.88277577
155pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.87004844
156regulation of urine volume (GO:0035809)2.85741671
157positive regulation of muscle tissue development (GO:1901863)2.80946932
158* cell fate specification (GO:0001708)2.80944867
159ventricular cardiac muscle cell development (GO:0055015)2.78979714
160lymph vessel development (GO:0001945)2.78870976
161viral transcription (GO:0019083)2.75776878
162morphogenesis of an epithelial fold (GO:0060571)2.74558919
163negative regulation of embryonic development (GO:0045992)2.74416690
164columnar/cuboidal epithelial cell development (GO:0002066)2.70856627
165transcytosis (GO:0045056)2.70169570
166pyrimidine nucleotide catabolic process (GO:0006244)2.69232009
167regulation of skeletal muscle cell differentiation (GO:2001014)2.68527158
168negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.67916646
169receptor guanylyl cyclase signaling pathway (GO:0007168)2.65575526
170* muscle organ morphogenesis (GO:0048644)2.65005453
171anterior/posterior pattern specification (GO:0009952)2.64350412
172embryonic cranial skeleton morphogenesis (GO:0048701)2.63970344
173regulation of secondary heart field cardioblast proliferation (GO:0003266)2.62523587
174regulation of cardioblast proliferation (GO:0003264)2.62523587
175translational termination (GO:0006415)2.58854646
176positive regulation of cardiac muscle cell proliferation (GO:0060045)2.55618704
177regulation of transcription involved in cell fate commitment (GO:0060850)2.54915059
178embryonic axis specification (GO:0000578)2.54808504
179mesenchymal to epithelial transition (GO:0060231)2.54194015
180paraxial mesoderm development (GO:0048339)2.53249425
181dorsal/ventral axis specification (GO:0009950)2.52118411
182organ formation (GO:0048645)2.51200799
183negative regulation of cell fate commitment (GO:0010454)2.51009708
184amyloid precursor protein catabolic process (GO:0042987)2.50638958
185negative regulation of striated muscle cell apoptotic process (GO:0010664)2.50459326
186epithelial cell-cell adhesion (GO:0090136)2.49521730
187embryonic process involved in female pregnancy (GO:0060136)2.49133485
188kinetochore organization (GO:0051383)2.48367961
189muscle hypertrophy in response to stress (GO:0003299)2.47552086
190cardiac muscle adaptation (GO:0014887)2.47552086
191daunorubicin metabolic process (GO:0044597)11.3766697
192polyketide metabolic process (GO:0030638)11.3766697
193doxorubicin metabolic process (GO:0044598)11.3766697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.93720218
2* KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.67507703
3* KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.67507703
4* KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.67507703
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.52860668
6E2F7_22180533_ChIP-Seq_HELA_Human3.94967576
7EZH2_22144423_ChIP-Seq_EOC_Human3.59003482
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.41978572
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.99081923
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.98179829
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.91298999
12* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.89376320
13* EED_16625203_ChIP-ChIP_MESCs_Mouse2.85357686
14* TP63_19390658_ChIP-ChIP_HaCaT_Human2.72696702
15TCF3_18692474_ChIP-Seq_MESCs_Mouse2.71105473
16TCF3_18692474_ChIP-Seq_MEFs_Mouse2.68040451
17* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.67695240
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.60002839
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54661997
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.52234698
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38607627
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34812970
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29849809
24* CBX2_27304074_Chip-Seq_ESCs_Mouse2.28919734
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.17851064
26* NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.10448959
27* SMAD3_21741376_ChIP-Seq_HESCs_Human2.06718277
28* NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.06158131
29* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04634701
30* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04634701
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97976464
32IRF1_19129219_ChIP-ChIP_H3396_Human1.94789140
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.93580111
34* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.90258160
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.90246486
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.89535076
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84542685
38ZNF263_19887448_ChIP-Seq_K562_Human1.82830251
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.81196586
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.80374467
41* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76639349
42POU5F1_16518401_ChIP-PET_MESCs_Mouse1.74848867
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.72791887
44* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71899204
45XRN2_22483619_ChIP-Seq_HELA_Human1.69134418
46* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.68881793
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.66722576
48* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.66371199
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65934978
50MYC_18555785_ChIP-Seq_MESCs_Mouse1.65427263
51* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63696162
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62607673
53NANOG_18692474_ChIP-Seq_MEFs_Mouse1.54765882
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53635543
55NANOG_18692474_ChIP-Seq_MESCs_Mouse1.53433419
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52368322
57STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.51449052
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50712152
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49687670
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48056047
61* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.47548052
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.46115570
63CDX2_20551321_ChIP-Seq_CACO-2_Human1.42973173
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41270441
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40823249
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40189749
67* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.38727467
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38609591
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37674457
70* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.35835306
71* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.35558719
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33280472
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32586065
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32319626
75* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31591703
76* SMAD4_21741376_ChIP-Seq_HESCs_Human1.30933636
77* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30662505
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30658513
79* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30194693
80* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.26950161
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26745561
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.23724463
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21515572
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.20649263
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20502681
86MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20431255
87* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18707023
88MYC_22102868_ChIP-Seq_BL_Human1.17081484
89GATA1_26923725_Chip-Seq_HPCs_Mouse1.16697521
90* NANOG_16518401_ChIP-PET_MESCs_Mouse1.16668555
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14159098
92ETS1_20019798_ChIP-Seq_JURKAT_Human1.13981718
93* RNF2_27304074_Chip-Seq_ESCs_Mouse1.13336629
94* NANOG_16153702_ChIP-ChIP_HESCs_Human1.12004691
95* EOMES_21245162_ChIP-Seq_HESCs_Human1.11321708
96KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11124345
97* EZH2_27294783_Chip-Seq_ESCs_Mouse1.09906488
98CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09862599
99TP53_22127205_ChIP-Seq_IMR90_Human1.09379961
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08213482
101NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07322960
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06153377
103* RING1B_27294783_Chip-Seq_ESCs_Mouse1.05983779
104NANOG_21062744_ChIP-ChIP_HESCs_Human1.05472953
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01343804
106NCOR1_26117541_ChIP-Seq_K562_Human0.99934189
107* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99601603
108GABP_19822575_ChIP-Seq_HepG2_Human0.99015021
109* SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97466017
110TTF2_22483619_ChIP-Seq_HELA_Human0.97168074
111CTCF_26484167_Chip-Seq_Bcells_Mouse0.96701880
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95843815
113LXR_22292898_ChIP-Seq_THP-1_Human0.93587041
114* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93423559
115* SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92770599
116DCP1A_22483619_ChIP-Seq_HELA_Human0.92395230
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92148067
118* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91446038
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91203006
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.90356157
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90345870
122FOXP1_21924763_ChIP-Seq_HESCs_Human0.90074623
123TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.89765982
124* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89457353
125KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88940107
126* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88563464
127TCF7_22412390_ChIP-Seq_EML_Mouse0.86711476
128TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86674405
129KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86062655
130TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85458355
131YY1_22570637_ChIP-Seq_MALME-3M_Human0.84486985
132SMC4_20622854_ChIP-Seq_HELA_Human0.84127544
133STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83693824
134EST1_17652178_ChIP-ChIP_JURKAT_Human0.82900949
135SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80429123
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79297461
137ELK3_25401928_ChIP-Seq_HUVEC_Human0.79131633
138EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.78636305
139ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.78017337
140KAP1_27257070_Chip-Seq_ESCs_Mouse0.77059608
141PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76997817
142CTCF_21964334_Chip-Seq_Bcells_Human0.76810362
143E2F1_18555785_ChIP-Seq_MESCs_Mouse0.76267588
144WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.74789447
145RACK7_27058665_Chip-Seq_MCF-7_Human0.74476099
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.73838629
147STAT3_18555785_ChIP-Seq_MESCs_Mouse0.73759772
148RING1B_27294783_Chip-Seq_NPCs_Mouse0.71711441
149KDM2B_26808549_Chip-Seq_K562_Human0.70846635
150* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.69709192
151ESR1_15608294_ChIP-ChIP_MCF-7_Human0.69650974
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.69588271
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.69385723
154SCL_19346495_ChIP-Seq_HPC-7_Human0.68672284
155* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.67477678
156* TP53_20018659_ChIP-ChIP_R1E_Mouse0.67112612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.99344652
2MP0002163_abnormal_gland_morphology4.67738941
3MP0006292_abnormal_olfactory_placode4.65800179
4MP0002254_reproductive_system_inflammat4.46798036
5MP0004264_abnormal_extraembryonic_tissu4.31448129
6MP0003890_abnormal_embryonic-extraembry4.16065424
7MP0004858_abnormal_nervous_system3.54358047
8MP0003122_maternal_imprinting3.34790759
9MP0005075_abnormal_melanosome_morpholog3.13526544
10MP0002234_abnormal_pharynx_morphology2.98828721
11MP0008057_abnormal_DNA_replication2.94685113
12MP0002332_abnormal_exercise_endurance2.94420507
13MP0005257_abnormal_intraocular_pressure2.85427596
14MP0005379_endocrine/exocrine_gland_phen2.80850080
15MP0004957_abnormal_blastocyst_morpholog2.80028910
16MP0002653_abnormal_ependyma_morphology2.51036595
17MP0003121_genomic_imprinting2.45459563
18MP0003705_abnormal_hypodermis_morpholog2.44020303
19MP0006035_abnormal_mitochondrial_morpho2.37054237
20MP0000678_abnormal_parathyroid_gland2.32626309
21MP0002102_abnormal_ear_morphology2.14179889
22MP0010352_gastrointestinal_tract_polyps2.12340624
23MP0000462_abnormal_digestive_system2.08802462
24MP0003938_abnormal_ear_development2.06529081
25MP0010030_abnormal_orbit_morphology2.04691262
26MP0001672_abnormal_embryogenesis/_devel1.92383884
27MP0005380_embryogenesis_phenotype1.92383884
28MP0005377_hearing/vestibular/ear_phenot1.81420701
29MP0003878_abnormal_ear_physiology1.81420701
30MP0003123_paternal_imprinting1.78820274
31MP0003183_abnormal_peptide_metabolism1.78192910
32MP0002127_abnormal_cardiovascular_syste1.78108496
33MP0002088_abnormal_embryonic_growth/wei1.77329289
34MP0003984_embryonic_growth_retardation1.74690040
35MP0008961_abnormal_basal_metabolism1.72435327
36MP0001293_anophthalmia1.71779064
37MP0005503_abnormal_tendon_morphology1.67894695
38MP0003385_abnormal_body_wall1.66544853
39MP0008004_abnormal_stomach_pH1.65685234
40MP0000049_abnormal_middle_ear1.64363953
41MP0001849_ear_inflammation1.55183048
42MP0006082_CNS_inflammation1.53149690
43MP0008789_abnormal_olfactory_epithelium1.50910993
44MP0002092_abnormal_eye_morphology1.48750440
45MP0005187_abnormal_penis_morphology1.46119907
46MP0000350_abnormal_cell_proliferation1.40726137
47MP0009384_cardiac_valve_regurgitation1.40074537
48MP0003693_abnormal_embryo_hatching1.37004642
49MP0002085_abnormal_embryonic_tissue1.35742173
50* MP0005499_abnormal_olfactory_system1.34562070
51* MP0005394_taste/olfaction_phenotype1.34562070
52MP0002086_abnormal_extraembryonic_tissu1.34278795
53MP0004043_abnormal_pH_regulation1.33814252
54MP0003077_abnormal_cell_cycle1.32558339
55MP0005266_abnormal_metabolism1.29860992
56MP0003119_abnormal_digestive_system1.29520552
57MP0001348_abnormal_lacrimal_gland1.29076614
58MP0009053_abnormal_anal_canal1.29010228
59MP0002114_abnormal_axial_skeleton1.28494869
60MP0005076_abnormal_cell_differentiation1.25333700
61* MP0002932_abnormal_joint_morphology1.22505873
62MP0003315_abnormal_perineum_morphology1.22182813
63MP0003136_yellow_coat_color1.21216751
64MP0002084_abnormal_developmental_patter1.19629813
65MP0004185_abnormal_adipocyte_glucose1.17806082
66MP0000432_abnormal_head_morphology1.17734038
67MP0003279_aneurysm1.13666003
68MP0004133_heterotaxia1.13576494
69MP0000383_abnormal_hair_follicle1.11120808
70MP0005248_abnormal_Harderian_gland1.09174522
71MP0010307_abnormal_tumor_latency1.06909473
72MP0004381_abnormal_hair_follicle1.06141972
73MP0002697_abnormal_eye_size1.05459192
74MP0002970_abnormal_white_adipose1.04719091
75MP0003137_abnormal_impulse_conducting1.03311585
76MP0002108_abnormal_muscle_morphology1.02534837
77MP0001486_abnormal_startle_reflex1.02231174
78MP0003111_abnormal_nucleus_morphology1.01971895
79MP0003283_abnormal_digestive_organ1.00025276
80MP0002396_abnormal_hematopoietic_system0.99835608
81MP0005508_abnormal_skeleton_morphology0.98243499
82MP0008770_decreased_survivor_rate0.98046871
83MP0002132_abnormal_respiratory_system0.97557870
84MP0008932_abnormal_embryonic_tissue0.97138318
85MP0004197_abnormal_fetal_growth/weight/0.96656727
86MP0003937_abnormal_limbs/digits/tail_de0.96196150
87MP0005391_vision/eye_phenotype0.96184800
88* MP0003935_abnormal_craniofacial_develop0.94800758
89MP0004142_abnormal_muscle_tone0.91304214
90MP0000733_abnormal_muscle_development0.90835685
91* MP0000762_abnormal_tongue_morphology0.89481940
92MP0001730_embryonic_growth_arrest0.89422900
93MP0001697_abnormal_embryo_size0.88131785
94MP0002925_abnormal_cardiovascular_devel0.87328495
95MP0000313_abnormal_cell_death0.86904243
96* MP0003755_abnormal_palate_morphology0.86177444
97MP0002751_abnormal_autonomic_nervous0.84962012
98MP0002796_impaired_skin_barrier0.84657402
99MP0002249_abnormal_larynx_morphology0.84071640
100MP0002080_prenatal_lethality0.82410083
101MP0002822_catalepsy0.81571527
102MP0000750_abnormal_muscle_regeneration0.79124495
103MP0000026_abnormal_inner_ear0.79104341
104MP0003936_abnormal_reproductive_system0.79028512
105MP0002098_abnormal_vibrissa_morphology0.78788072
106MP0000490_abnormal_crypts_of0.77618933
107* MP0002233_abnormal_nose_morphology0.76318982
108MP0010094_abnormal_chromosome_stability0.74460197
109* MP0002116_abnormal_craniofacial_bone0.74206623
110MP0000372_irregular_coat_pigmentation0.73976988
111MP0000749_muscle_degeneration0.73549989
112MP0009703_decreased_birth_body0.73292525
113MP0002111_abnormal_tail_morphology0.72983380
114MP0003787_abnormal_imprinting0.72671910
115MP0000767_abnormal_smooth_muscle0.72573824
116MP0002269_muscular_atrophy0.71542424
117MP0003879_abnormal_hair_cell0.70755618
118MP0001881_abnormal_mammary_gland0.70217414
119MP0001286_abnormal_eye_development0.70123356
120MP0008995_early_reproductive_senescence0.68316081
121* MP0000163_abnormal_cartilage_morphology0.67838741
122MP0000358_abnormal_cell_content/0.67746071
123MP0001727_abnormal_embryo_implantation0.67559836
124MP0005023_abnormal_wound_healing0.67550193
125MP0002210_abnormal_sex_determination0.66916993
126MP0005623_abnormal_meninges_morphology0.66416622
127MP0010678_abnormal_skin_adnexa0.64751426
128* MP0000428_abnormal_craniofacial_morphol0.62847666
129MP0003567_abnormal_fetal_cardiomyocyte0.62259679
130MP0003861_abnormal_nervous_system0.62255037
131MP0003718_maternal_effect0.62207516
132* MP0000759_abnormal_skeletal_muscle0.62054431
133MP0009250_abnormal_appendicular_skeleto0.60220742
134* MP0002081_perinatal_lethality0.60184909
135MP0000534_abnormal_ureter_morphology0.59831173
136MP0008007_abnormal_cellular_replicative0.59354006
137MP0005501_abnormal_skin_physiology0.58616647
138MP0004883_abnormal_blood_vessel0.58415394
139MP0005666_abnormal_adipose_tissue0.58002871
140MP0003942_abnormal_urinary_system0.57893155
141MP0001485_abnormal_pinna_reflex0.57723039
142MP0000377_abnormal_hair_follicle0.56537796
143MP0005197_abnormal_uvea_morphology0.55939682
144MP0002109_abnormal_limb_morphology0.54664403
145MP0005384_cellular_phenotype0.53171294

Predicted human phenotypes

RankGene SetZ-score
1Congenital malformation of the right heart (HP:0011723)7.85856141
2Double outlet right ventricle (HP:0001719)7.85856141
3Bilateral microphthalmos (HP:0007633)7.75545097
4Hypochromic microcytic anemia (HP:0004840)6.18195245
5Transposition of the great arteries (HP:0001669)5.89621632
6Abnormal connection of the cardiac segments (HP:0011545)5.89621632
7Abnormal ventriculo-arterial connection (HP:0011563)5.89621632
8Abnormality of the fetal cardiovascular system (HP:0010948)5.75180198
9Abnormal umbilical cord blood vessels (HP:0011403)5.75180198
10Single umbilical artery (HP:0001195)5.75180198
11Hepatoblastoma (HP:0002884)5.68757658
12Multiple enchondromatosis (HP:0005701)5.47549542
13Rib fusion (HP:0000902)5.18944674
14Abnormality of the lower motor neuron (HP:0002366)4.98969257
15Short middle phalanx of the 5th finger (HP:0004220)4.65729139
16Abnormality of the aortic arch (HP:0012303)4.55095254
17Ependymoma (HP:0002888)4.29230478
18Abdominal situs inversus (HP:0003363)4.05820580
19Abnormality of abdominal situs (HP:0011620)4.05820580
20Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.95919392
21Abnormality of the umbilical cord (HP:0010881)3.94079919
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.86883536
23Neoplasm of striated muscle (HP:0009728)3.75943766
24Partial duplication of thumb phalanx (HP:0009944)3.71318455
25Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.69186718
26Testicular atrophy (HP:0000029)3.68237919
27Nephroblastoma (Wilms tumor) (HP:0002667)3.66526008
28Rectal fistula (HP:0100590)3.62026826
29Rectovaginal fistula (HP:0000143)3.62026826
30* Periauricular skin pits (HP:0100277)3.60150781
31* Preauricular pit (HP:0004467)3.60150781
32Rhabdomyosarcoma (HP:0002859)3.54282077
33Bifid tongue (HP:0010297)3.48271021
34Fused cervical vertebrae (HP:0002949)3.45799626
35Hypoplasia of the fovea (HP:0007750)3.43953876
36Aplasia/Hypoplasia of the fovea (HP:0008060)3.43953876
37Chromosomal breakage induced by crosslinking agents (HP:0003221)3.42120379
38Embryonal renal neoplasm (HP:0011794)3.40369529
39Abnormality of the parathyroid morphology (HP:0011766)3.38272803
40Partial duplication of the phalanx of hand (HP:0009999)3.33327611
41Hypoplastic left heart (HP:0004383)3.30305481
42Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.30228386
43Intestinal fistula (HP:0100819)3.23735235
44Abnormality of the distal phalanges of the toes (HP:0010182)3.18846134
45Anomalous pulmonary venous return (HP:0010772)3.17614988
46Vaginal fistula (HP:0004320)3.14148152
47Ragged-red muscle fibers (HP:0003200)3.12399291
48Abnormality of the phalanges of the 5th finger (HP:0004213)3.12006880
49Abnormality of the salivary glands (HP:0010286)3.09780257
50Amyotrophic lateral sclerosis (HP:0007354)3.07741398
51Abnormality of the astrocytes (HP:0100707)3.05889360
52Astrocytoma (HP:0009592)3.05889360
53Hyperinsulinemic hypoglycemia (HP:0000825)3.04581114
54Broad distal phalanx of finger (HP:0009836)3.04446082
55Trismus (HP:0000211)2.99534746
56Abnormal cartilage morphology (HP:0002763)2.98643537
57Truncus arteriosus (HP:0001660)2.94336069
58Abnormal lung lobation (HP:0002101)2.93491908
59Chromsome breakage (HP:0040012)2.87253433
60Horizontal nystagmus (HP:0000666)2.83364751
61Preauricular skin tag (HP:0000384)2.81758315
62Abnormality of the phalanges of the hallux (HP:0010057)2.78578442
63Abnormality of the middle phalanges of the toes (HP:0010183)2.76028495
64Abnormality of the pulmonary veins (HP:0011718)2.71852334
65Patent foramen ovale (HP:0001655)2.70939965
66Generalized hypotonia (HP:0001290)2.66350935
67Shawl scrotum (HP:0000049)2.61778612
68Abnormality of the fovea (HP:0000493)2.57599370
69Short clavicles (HP:0000894)2.56216827
70Hypochromic anemia (HP:0001931)2.55510758
71Sensory axonal neuropathy (HP:0003390)2.52928033
72Large earlobe (HP:0009748)2.52221970
73Reduced antithrombin III activity (HP:0001976)2.51912630
74Hyperventilation (HP:0002883)2.51892564
75Anal stenosis (HP:0002025)2.51740685
76Oligodactyly (HP:0012165)2.51686584
77Progressive muscle weakness (HP:0003323)2.51565356
78Nasolacrimal duct obstruction (HP:0000579)2.48970939
79* Skin pits (HP:0100276)2.48497030
80Skin tags (HP:0010609)2.47416553
81Short 5th finger (HP:0009237)2.45938266
82Hypoplastic heart (HP:0001961)2.44341447
83Absent radius (HP:0003974)2.42980182
84Abnormal pancreas size (HP:0012094)2.42232966
85Abnormality of the distal phalanx of the thumb (HP:0009617)2.40384093
86Unilateral renal agenesis (HP:0000122)2.40303119
87Impulsivity (HP:0100710)2.38473434
88Renal duplication (HP:0000075)2.37666231
89Pendular nystagmus (HP:0012043)2.36670611
90Premature skin wrinkling (HP:0100678)2.36326380
91Tetraplegia (HP:0002445)2.36287862
92Meckel diverticulum (HP:0002245)2.35814096
93Aplasia/Hypoplasia of the clavicles (HP:0006710)2.34747635
94Supernumerary spleens (HP:0009799)2.33828907
95Chin dimple (HP:0010751)2.31022598
96Increased connective tissue (HP:0009025)2.26830794
97Tongue fasciculations (HP:0001308)2.25814886
98Glioma (HP:0009733)2.25565912
99Aplasia involving forearm bones (HP:0009822)2.25044423
100Absent forearm bone (HP:0003953)2.25044423
101Renal dysplasia (HP:0000110)2.24171545
102Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.23629368
103Aplasia/Hypoplasia of the macula (HP:0008059)2.23343402
104Abnormality of chromosome segregation (HP:0002916)2.23331407
105Neoplasm of the heart (HP:0100544)2.23070991
106Microretrognathia (HP:0000308)2.22937487
107Calcaneovalgus deformity (HP:0001848)2.21807041
108Difficulty running (HP:0009046)2.21233209
109Abnormality of the musculature of the hand (HP:0001421)2.20641633
110Occipital encephalocele (HP:0002085)2.20416807
111Gonadal dysgenesis (HP:0000133)2.20410775
112Abnormality of the ileum (HP:0001549)2.19668189
113Hypopigmentation of the fundus (HP:0007894)2.19292746
114Aplasia/Hypoplasia of the uvula (HP:0010293)2.18395667
115Glossoptosis (HP:0000162)2.16976095
116Myelomeningocele (HP:0002475)2.15421101
117Villous atrophy (HP:0011473)2.15374524
118Abnormality of small intestinal villus morphology (HP:0011472)2.15374524
119Down-sloping shoulders (HP:0200021)2.13897984
120Progressive external ophthalmoplegia (HP:0000590)2.13868649
121Upper motor neuron abnormality (HP:0002127)2.12375700
122Malignant neoplasm of the central nervous system (HP:0100836)2.10968256
123Upper limb muscle weakness (HP:0003484)2.10051329
124Concave nail (HP:0001598)2.10025849
125Ureteral duplication (HP:0000073)2.09906727
126Deformed tarsal bones (HP:0008119)2.09570586
127Midline defect of the nose (HP:0004122)2.09262896
128Abnormalities of placenta or umbilical cord (HP:0001194)2.08625961
129Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.07784798
130Vertebral fusion (HP:0002948)2.06593702
131Muscle fibrillation (HP:0010546)2.05850152
132Oligodactyly (hands) (HP:0001180)2.04814792
133Esophageal atresia (HP:0002032)2.03893717
134Cheilitis (HP:0100825)2.03724244
135Pseudobulbar signs (HP:0002200)2.03390260
136Hand muscle atrophy (HP:0009130)2.03004944
137Prominent occiput (HP:0000269)2.00770051
138Premature ovarian failure (HP:0008209)2.00681762
139Aplasia/Hypoplasia of the sternum (HP:0006714)2.00551922
140Cutaneous finger syndactyly (HP:0010554)2.00062163
141Aplasia/Hypoplasia affecting the retina (HP:0008061)1.99907054
142Abnormal sex determination (HP:0012244)1.99601554
143Sex reversal (HP:0012245)1.99601554
144Supernumerary nipples (HP:0002558)1.98783885
145Duplication of thumb phalanx (HP:0009942)1.98019818
146Tracheal stenosis (HP:0002777)1.97466531
147Anteriorly placed anus (HP:0001545)1.97345657
148Microvesicular hepatic steatosis (HP:0001414)1.96728824
149Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96647716
150Hydroureter (HP:0000072)1.95643967
151Achilles tendon contracture (HP:0001771)1.94340577
152Atrophy/Degeneration involving motor neurons (HP:0007373)1.94087793
153Malnutrition (HP:0004395)1.92962248
1543-Methylglutaconic aciduria (HP:0003535)1.92820200
155Cutaneous syndactyly (HP:0012725)1.92137463
156Maternal diabetes (HP:0009800)1.91671705
157Testicular neoplasm (HP:0010788)1.91532455
158Preaxial foot polydactyly (HP:0001841)1.91289172
159Long palpebral fissure (HP:0000637)1.90898506
160Breast aplasia (HP:0100783)1.90440709
161Facial cleft (HP:0002006)1.90102351
162Aplastic anemia (HP:0001915)1.88605080
163Abnormality of glycosphingolipid metabolism (HP:0004343)1.86310623
164Anal atresia (HP:0002023)1.85278135
165Aplasia/Hypoplasia of the breasts (HP:0010311)1.83208357
166Septo-optic dysplasia (HP:0100842)1.78384966
167Symphalangism affecting the phalanges of the hand (HP:0009773)1.77630264
168Ectopic anus (HP:0004397)1.76078031
169Anophthalmia (HP:0000528)1.75813925
170Mesomelia (HP:0003027)1.73588418
171Renal agenesis (HP:0000104)1.68136961
172Hydronephrosis (HP:0000126)1.66152628
173Shallow orbits (HP:0000586)1.64103000
174Selective tooth agenesis (HP:0001592)1.63393192
175Abnormality of the calcaneus (HP:0008364)1.60788741
176Pulmonary artery stenosis (HP:0004415)1.60562137
177Deep palmar crease (HP:0006191)1.60235816
178Hallux valgus (HP:0001822)1.60194996
179Broad toe (HP:0001837)1.59466223
180Birth length less than 3rd percentile (HP:0003561)1.59220059
181Bifid scrotum (HP:0000048)1.59087220
182Carpal synostosis (HP:0009702)1.56466593
183Deviation of the hallux (HP:0010051)1.55584758
184Broad phalanges of the hand (HP:0009768)1.54475635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.42085237
2GRK55.71926870
3GRK64.67073629
4NME14.59491594
5SMG14.58413743
6ERN14.52718600
7VRK24.39100798
8TRIB34.16892558
9GRK13.49649393
10ADRBK23.48668697
11TAF13.29852902
12CSF1R2.92883941
13ERBB42.91101219
14NME22.85662622
15TYRO32.65765401
16TGFBR22.63075937
17TTK2.47469191
18GRK72.46641661
19PKN22.43884021
20MAPK72.30360770
21PRKD32.24080231
22MATK2.23459024
23STK102.14546518
24ARAF2.10552940
25MOS2.08606435
26WNK12.02719765
27ACVR1B1.96052427
28DMPK1.86695775
29BRAF1.79990075
30EEF2K1.67341807
31BMPR1B1.58328536
32PBK1.58058117
33STK161.56941186
34NUAK11.56468161
35NTRK11.54089266
36CAMK41.50972130
37CDK71.50510247
38MELK1.46460123
39PDK21.46406124
40PRKG21.41486482
41EPHA21.33711198
42MARK21.28951960
43LRRK21.28132459
44VRK11.26577575
45PAK41.25131482
46AKT31.23445455
47CAMK1D1.18396651
48ADRBK11.18152758
49LATS21.16131610
50MAP2K41.14231582
51MAP3K101.12375003
52BRSK11.11624517
53MAPKAPK51.11431546
54CHEK21.11190913
55DAPK11.06156333
56MKNK21.05637188
57HIPK21.04272472
58PLK11.03218902
59FGFR30.95332999
60ILK0.94653577
61PLK40.88732330
62IRAK20.85270552
63TEC0.81295099
64TRIM280.80906386
65ALK0.80505816
66DAPK30.79695695
67AKT20.77868766
68MAP2K60.75335376
69RPS6KC10.74242862
70RPS6KL10.74242862
71CAMK1G0.71733051
72CHEK10.70255252
73CSK0.68604372
74MAP3K130.67010888
75MAPK120.66248091
76MAP2K20.65957218
77BCKDK0.65685689
78MAP3K70.65301706
79MAPK150.63921798
80IRAK30.63892031
81RPS6KA20.63278716
82EIF2AK20.62389112
83RPS6KA60.58565917
84CSNK1G10.58415424
85CDK90.55897772
86MAP3K80.55294090
87CSNK1A1L0.52429749
88STK40.51794619
89MTOR0.51213273
90CSNK1G30.48485107
91MAP3K90.46344123
92PRKCI0.45419409
93NEK60.45302421
94NEK20.43776013
95TGFBR10.43256653
96EPHA40.43061922
97PIM20.42887332
98AURKA0.42244559
99CDC70.41967199
100BUB10.41725144
101CDK20.41716191
102IGF1R0.41619633
103CAMK2G0.41492466
104MKNK10.40886388
105PTK20.39076329
106ATR0.37898321
107PDGFRA0.37742572
108PLK30.35985963
109ITK0.35771613
110ERBB20.34167936
111PAK10.33206642
112TESK10.33145147
113WEE10.32316752
114RPS6KA10.32264826
115CSNK1E0.31947532
116PRKCD0.31449837
117RPS6KB20.30417302
118RAF10.29906783
119DYRK20.29263653
120DDR20.29011948
121PRKD20.27445766
122MAPK100.26920427
123ATM0.26860855
124ABL20.26701469
125AURKB0.26308499
126CDK40.26078131
127IKBKB0.25958047
128BMX0.25692847
129RPS6KA50.25427601
130STK380.25315064
131RIPK10.22855058
132DYRK30.22450924
133CDK10.21787293
134INSR0.21140836
135CDK150.19339362
136ICK0.18227646
137PRKCG0.17819766
138GSK3B0.17648051
139PRKACG0.17523212
140DYRK1A0.17097511
141CDK11A0.16925072
142MAPK10.16813278
143SRPK10.16173945
144MAPK40.15657206
145CDK180.15486690
146GSK3A0.15163180
147MAPK140.14727146
148PRKACB0.13584453
149DYRK1B0.12965537
150TESK20.12708472
151PRKAA10.12463318
152SIK10.11524628
153PAK30.11335633
154TAOK10.10214208
155PRKACA0.09880121
156TAOK20.09402326
157NEK10.09046936
158CDK140.08893467
159CDK80.08382358
160PRPF4B0.08002373
161RPS6KA30.07674273
162CHUK0.07102656

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.10895185
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.39951357
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.17671683
4Fructose and mannose metabolism_Homo sapiens_hsa000513.95777572
5Galactose metabolism_Homo sapiens_hsa000522.71756699
6Arachidonic acid metabolism_Homo sapiens_hsa005902.69966938
7TGF-beta signaling pathway_Homo sapiens_hsa043502.69958735
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.43010265
9Linoleic acid metabolism_Homo sapiens_hsa005912.28620575
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.14841965
11Cysteine and methionine metabolism_Homo sapiens_hsa002701.92558723
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.91415698
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.90622588
14Maturity onset diabetes of the young_Homo sapiens_hsa049501.85750004
15RNA transport_Homo sapiens_hsa030131.72550230
16Melanoma_Homo sapiens_hsa052181.69974408
17mTOR signaling pathway_Homo sapiens_hsa041501.64418956
18Thyroid cancer_Homo sapiens_hsa052161.62435876
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.58762445
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50036432
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41970141
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41171654
23mRNA surveillance pathway_Homo sapiens_hsa030151.31988381
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29311599
25Fanconi anemia pathway_Homo sapiens_hsa034601.29199863
26Ribosome_Homo sapiens_hsa030101.25037261
27Sulfur metabolism_Homo sapiens_hsa009201.24938559
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23273846
29Pyruvate metabolism_Homo sapiens_hsa006201.21709334
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18845724
31One carbon pool by folate_Homo sapiens_hsa006701.16062031
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11572767
33Basal cell carcinoma_Homo sapiens_hsa052171.10003395
34Cell cycle_Homo sapiens_hsa041101.08563248
35Ovarian steroidogenesis_Homo sapiens_hsa049131.04215632
36Chemical carcinogenesis_Homo sapiens_hsa052041.01461415
37Huntingtons disease_Homo sapiens_hsa050161.01229620
38Arginine and proline metabolism_Homo sapiens_hsa003301.00966578
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.00291623
40Pyrimidine metabolism_Homo sapiens_hsa002400.99030637
41DNA replication_Homo sapiens_hsa030300.98969767
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98715865
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.97073346
44Fatty acid elongation_Homo sapiens_hsa000620.96847505
45Colorectal cancer_Homo sapiens_hsa052100.96718991
46Hedgehog signaling pathway_Homo sapiens_hsa043400.96666898
47Ether lipid metabolism_Homo sapiens_hsa005650.96152672
48RNA degradation_Homo sapiens_hsa030180.92047772
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91829232
50Nucleotide excision repair_Homo sapiens_hsa034200.88925733
51Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88521807
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.85432768
53Parkinsons disease_Homo sapiens_hsa050120.85224691
54Inositol phosphate metabolism_Homo sapiens_hsa005620.84932405
55Glioma_Homo sapiens_hsa052140.84807724
56Mismatch repair_Homo sapiens_hsa034300.84450574
57Endometrial cancer_Homo sapiens_hsa052130.84285942
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84262051
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84041583
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83718464
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82055794
62Other glycan degradation_Homo sapiens_hsa005110.81939125
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81400345
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81241652
65Homologous recombination_Homo sapiens_hsa034400.79916654
66Melanogenesis_Homo sapiens_hsa049160.79698082
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.79473675
68Spliceosome_Homo sapiens_hsa030400.79380013
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79259962
70Sphingolipid metabolism_Homo sapiens_hsa006000.79081077
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78447091
72Pathways in cancer_Homo sapiens_hsa052000.78402147
73Lysine degradation_Homo sapiens_hsa003100.77728574
74Pentose phosphate pathway_Homo sapiens_hsa000300.76031723
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75489393
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74217894
77p53 signaling pathway_Homo sapiens_hsa041150.74027551
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73840729
79MicroRNAs in cancer_Homo sapiens_hsa052060.72537560
80Sulfur relay system_Homo sapiens_hsa041220.71161804
81Choline metabolism in cancer_Homo sapiens_hsa052310.70699680
82Rap1 signaling pathway_Homo sapiens_hsa040150.70697212
83Hippo signaling pathway_Homo sapiens_hsa043900.70306128
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68158900
85Folate biosynthesis_Homo sapiens_hsa007900.67558481
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65617102
87Purine metabolism_Homo sapiens_hsa002300.65160724
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.64167412
89Small cell lung cancer_Homo sapiens_hsa052220.62240181
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61793496
91Glutathione metabolism_Homo sapiens_hsa004800.61417258
92Acute myeloid leukemia_Homo sapiens_hsa052210.59182031
93Tryptophan metabolism_Homo sapiens_hsa003800.58764783
94Bladder cancer_Homo sapiens_hsa052190.58540856
95Prostate cancer_Homo sapiens_hsa052150.58308887
96RNA polymerase_Homo sapiens_hsa030200.57528046
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56436629
98Oocyte meiosis_Homo sapiens_hsa041140.55842840
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55209796
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54720475
101Steroid biosynthesis_Homo sapiens_hsa001000.52874312
102Oxidative phosphorylation_Homo sapiens_hsa001900.52450882
103N-Glycan biosynthesis_Homo sapiens_hsa005100.51721615
104Non-small cell lung cancer_Homo sapiens_hsa052230.51687223
105African trypanosomiasis_Homo sapiens_hsa051430.50460885
106Wnt signaling pathway_Homo sapiens_hsa043100.50013906
107Fatty acid metabolism_Homo sapiens_hsa012120.46613958
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45183165
109Carbon metabolism_Homo sapiens_hsa012000.45151587
110Chronic myeloid leukemia_Homo sapiens_hsa052200.43965161
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43929467
112Insulin signaling pathway_Homo sapiens_hsa049100.43795547
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43474151
114Base excision repair_Homo sapiens_hsa034100.42450980
115Proteoglycans in cancer_Homo sapiens_hsa052050.41487104
116Regulation of autophagy_Homo sapiens_hsa041400.40285091
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39888968
118AMPK signaling pathway_Homo sapiens_hsa041520.38779163
119Taste transduction_Homo sapiens_hsa047420.38472162
120Metabolic pathways_Homo sapiens_hsa011000.37976495
121Biosynthesis of amino acids_Homo sapiens_hsa012300.37937742
122ErbB signaling pathway_Homo sapiens_hsa040120.37129503
123Basal transcription factors_Homo sapiens_hsa030220.34919123
124Notch signaling pathway_Homo sapiens_hsa043300.34847937
125VEGF signaling pathway_Homo sapiens_hsa043700.34771214
126Complement and coagulation cascades_Homo sapiens_hsa046100.34292055
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34053187
128Herpes simplex infection_Homo sapiens_hsa051680.33775407
129Tight junction_Homo sapiens_hsa045300.33773701
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33743933
131Ras signaling pathway_Homo sapiens_hsa040140.33674898
132Propanoate metabolism_Homo sapiens_hsa006400.33627624
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32761378
134Retinol metabolism_Homo sapiens_hsa008300.32221823
135Selenocompound metabolism_Homo sapiens_hsa004500.32070377
136Calcium signaling pathway_Homo sapiens_hsa040200.31250490
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28906687
138Apoptosis_Homo sapiens_hsa042100.25744204
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.24683322
140Protein digestion and absorption_Homo sapiens_hsa049740.22187999
141Adherens junction_Homo sapiens_hsa045200.20931649
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.20631512
143Long-term depression_Homo sapiens_hsa047300.20554997
144Serotonergic synapse_Homo sapiens_hsa047260.20371451
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20357243
146GnRH signaling pathway_Homo sapiens_hsa049120.19522267
147HTLV-I infection_Homo sapiens_hsa051660.19514867
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18330373
149Pancreatic cancer_Homo sapiens_hsa052120.17951534
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.17677534

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