GSDMA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)7.55218801
2desmosome organization (GO:0002934)7.55217448
3artery development (GO:0060840)7.49434986
4L-fucose catabolic process (GO:0042355)6.99290450
5fucose catabolic process (GO:0019317)6.99290450
6L-fucose metabolic process (GO:0042354)6.99290450
7prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060526.87985703
8Golgi transport vesicle coating (GO:0048200)6.71064851
9COPI coating of Golgi vesicle (GO:0048205)6.71064851
10prostate gland epithelium morphogenesis (GO:0060740)6.64233673
11mitotic cell cycle arrest (GO:0071850)6.55792223
12molting cycle (GO:0042303)6.50532947
13hair cycle (GO:0042633)6.50532947
14establishment of skin barrier (GO:0061436)6.43132597
15response to testosterone (GO:0033574)6.21876781
16regulation of water loss via skin (GO:0033561)6.16376297
17positive regulation of steroid hormone secretion (GO:2000833)6.08843278
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.03476977
19mannose metabolic process (GO:0006013)5.85194136
20regulation of receptor binding (GO:1900120)5.68226989
21ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)5.65227193
22peptide cross-linking (GO:0018149)5.40797854
23activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.39796649
24fucose metabolic process (GO:0006004)5.37108145
25keratinization (GO:0031424)5.36690456
26intestinal epithelial cell development (GO:0060576)5.26653300
27N-glycan processing (GO:0006491)5.19605556
28positive regulation of nuclease activity (GO:0032075)5.14239006
29phosphatidylinositol acyl-chain remodeling (GO:0036149)5.12368182
30sphingoid metabolic process (GO:0046519)5.01952338
31pharyngeal system development (GO:0060037)5.01580621
32activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)4.81253330
33hormone catabolic process (GO:0042447)4.79605590
34behavioral response to nicotine (GO:0035095)4.72583596
35protein retention in ER lumen (GO:0006621)4.72374768
36galactose catabolic process (GO:0019388)4.72063693
37regulation of nuclease activity (GO:0032069)4.67161268
38positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)4.61063045
39endoplasmic reticulum unfolded protein response (GO:0030968)4.57028530
40epithelial cell maturation (GO:0002070)4.56884037
41positive regulation of growth hormone secretion (GO:0060124)4.55027257
42lung secretory cell differentiation (GO:0061140)4.54088152
43glandular epithelial cell differentiation (GO:0002067)4.53827053
44cellular response to unfolded protein (GO:0034620)4.43978215
45diol metabolic process (GO:0034311)4.43422251
46phosphatidylserine acyl-chain remodeling (GO:0036150)4.39912231
47epithelial cell differentiation involved in prostate gland development (GO:0060742)4.31865589
48ER-nucleus signaling pathway (GO:0006984)4.27906831
49valine metabolic process (GO:0006573)4.27482692
50COPII vesicle coating (GO:0048208)4.21063028
51multicellular organismal water homeostasis (GO:0050891)4.14206064
52response to endoplasmic reticulum stress (GO:0034976)4.12592887
53pyrimidine-containing compound transmembrane transport (GO:0072531)4.12078357
54phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.10994478
55regulation of steroid hormone secretion (GO:2000831)4.10186492
56cellular response to topologically incorrect protein (GO:0035967)4.09585341
57retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.04424464
58intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)4.01884839
59ER overload response (GO:0006983)4.00277021
60GDP-mannose metabolic process (GO:0019673)3.96952057
61response to pheromone (GO:0019236)3.93313090
62potassium ion homeostasis (GO:0055075)3.90857474
63bundle of His cell to Purkinje myocyte communication (GO:0086069)3.86114671
64UDP-N-acetylglucosamine metabolic process (GO:0006047)3.82185842
65positive regulation of natural killer cell differentiation (GO:0032825)3.79593759
66keratinocyte differentiation (GO:0030216)3.76676479
67regulation of growth hormone secretion (GO:0060123)3.71574103
68long-chain fatty acid biosynthetic process (GO:0042759)3.69668004
69sphingosine metabolic process (GO:0006670)3.69448036
70glucosamine-containing compound catabolic process (GO:1901072)3.68482188
71positive regulation of catenin import into nucleus (GO:0035413)3.67943991
72platelet dense granule organization (GO:0060155)3.66179247
73phosphatidylcholine acyl-chain remodeling (GO:0036151)3.59501098
74protein N-linked glycosylation via asparagine (GO:0018279)3.54060755
75fucosylation (GO:0036065)3.53043282
76regulation of natural killer cell differentiation (GO:0032823)3.52682879
77peptidyl-asparagine modification (GO:0018196)3.52528664
78DNA deamination (GO:0045006)3.52323533
79response to unfolded protein (GO:0006986)3.50857149
80vitamin transmembrane transport (GO:0035461)3.49348071
81indolalkylamine metabolic process (GO:0006586)3.47762761
82hemidesmosome assembly (GO:0031581)3.45677717
83indole-containing compound catabolic process (GO:0042436)3.45489404
84indolalkylamine catabolic process (GO:0046218)3.45489404
85tryptophan catabolic process (GO:0006569)3.45489404
86regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.40247825
87intermediate filament organization (GO:0045109)3.38860886
88nucleotide-sugar biosynthetic process (GO:0009226)3.38717309
89protein autoprocessing (GO:0016540)3.38631663
90keratinocyte proliferation (GO:0043616)3.37696142
91water homeostasis (GO:0030104)3.36720011
92calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.35815108
93phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.33054490
94sequestering of metal ion (GO:0051238)3.32741953
95negative regulation of mast cell activation (GO:0033004)3.31716325
96regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.30464256
97detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29305447
98response to topologically incorrect protein (GO:0035966)3.26775827
99positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.26345750
100protein N-linked glycosylation (GO:0006487)3.23243632
101detection of light stimulus involved in visual perception (GO:0050908)3.21625550
102detection of light stimulus involved in sensory perception (GO:0050962)3.21625550
103peptide catabolic process (GO:0043171)3.20044615
104epidermis development (GO:0008544)3.19550173
105apoptotic cell clearance (GO:0043277)3.18059036
106mammary gland alveolus development (GO:0060749)3.18038037
107tryptophan metabolic process (GO:0006568)3.17498309
108piRNA metabolic process (GO:0034587)3.14759622
109zinc ion transport (GO:0006829)3.12395354
110hexose catabolic process (GO:0019320)3.09110300
111keratinocyte development (GO:0003334)3.06850394
112epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06678637
113water-soluble vitamin biosynthetic process (GO:0042364)3.06327177
114negative regulation of telomere maintenance (GO:0032205)3.06234399
115vesicle coating (GO:0006901)3.03546000
116kynurenine metabolic process (GO:0070189)3.02237339
117epidermal cell differentiation (GO:0009913)3.01692967
118cellular modified amino acid catabolic process (GO:0042219)2.98951951
119signal peptide processing (GO:0006465)2.98136345
120glycerophospholipid catabolic process (GO:0046475)2.97578399
121positive regulation of fatty acid transport (GO:2000193)2.94717289
122angiotensin maturation (GO:0002003)2.92702399
123nucleotide-sugar metabolic process (GO:0009225)2.92535787
124beta-amyloid metabolic process (GO:0050435)2.90969473
125SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.86744726
126protein targeting to ER (GO:0045047)2.86482072
127regulation of cilium movement (GO:0003352)2.85867400
128cornea development in camera-type eye (GO:0061303)2.85729468
129cellular biogenic amine catabolic process (GO:0042402)2.84926680
130amine catabolic process (GO:0009310)2.84926680
131protein targeting to Golgi (GO:0000042)2.83724502
132lipoxygenase pathway (GO:0019372)2.82240973
133magnesium ion transport (GO:0015693)2.81600047
134DNA methylation involved in gamete generation (GO:0043046)2.73861006
135intermediate filament cytoskeleton organization (GO:0045104)2.73196791
136intermediate filament-based process (GO:0045103)2.72452106
137adaptation of signaling pathway (GO:0023058)2.69416851
138positive regulation of prostaglandin secretion (GO:0032308)2.67035248
139cellular ketone body metabolic process (GO:0046950)2.63666714
140positive regulation of icosanoid secretion (GO:0032305)2.63332823
141gamma-aminobutyric acid transport (GO:0015812)2.62671973
142fatty acid elongation (GO:0030497)2.60516669
143protein K11-linked deubiquitination (GO:0035871)2.58383251
144indole-containing compound metabolic process (GO:0042430)2.57719667
145parturition (GO:0007567)2.57405564
146GPI anchor metabolic process (GO:0006505)2.55224080
147phospholipid catabolic process (GO:0009395)2.54215584
148sulfation (GO:0051923)2.54189295
149negative regulation of systemic arterial blood pressure (GO:0003085)2.53479413
150kidney morphogenesis (GO:0060993)2.53435756
151preassembly of GPI anchor in ER membrane (GO:0016254)2.52777696
152ketone body metabolic process (GO:1902224)2.50812166
153nonmotile primary cilium assembly (GO:0035058)2.49035980
154dopamine transport (GO:0015872)2.47252242
155neuronal action potential (GO:0019228)2.46172535
156positive regulation of heat generation (GO:0031652)2.44788670
157phosphatidylserine metabolic process (GO:0006658)2.44041682
158regulation of action potential (GO:0098900)2.42244832
159axoneme assembly (GO:0035082)2.41085732
160primary amino compound metabolic process (GO:1901160)2.40805654
161reflex (GO:0060004)2.40066745
162regulation of rhodopsin mediated signaling pathway (GO:0022400)2.38218678
163positive regulation of defense response to virus by host (GO:0002230)2.35912319
164regulation of heat generation (GO:0031650)2.34321892
165negative regulation of reactive oxygen species metabolic process (GO:2000378)2.34184424
166regulation of mesoderm development (GO:2000380)2.33225060
167multicellular organism reproduction (GO:0032504)2.30951831
168regulation of glucokinase activity (GO:0033131)2.30795502
169regulation of hexokinase activity (GO:1903299)2.30795502
170protein polyglutamylation (GO:0018095)2.29093824
171rhodopsin mediated signaling pathway (GO:0016056)2.29034429
172positive regulation of T-helper 1 type immune response (GO:0002827)2.28448786
173G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.28442539
174synaptic transmission, cholinergic (GO:0007271)2.27788317
175lateral sprouting from an epithelium (GO:0060601)2.26920785
176linoleic acid metabolic process (GO:0043651)2.26379382
177phosphatidylglycerol metabolic process (GO:0046471)2.24844696
178serotonin metabolic process (GO:0042428)2.24480272
179positive regulation of glomerulus development (GO:0090193)2.23973861
180branching involved in prostate gland morphogenesis (GO:0060442)10.2521687

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.50749476
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.14976571
3VDR_22108803_ChIP-Seq_LS180_Human3.16191410
4SOX2_27498859_Chip-Seq_STOMACH_Mouse2.94730746
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.93320978
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.70811705
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.70811705
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.70811705
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64358952
10GBX2_23144817_ChIP-Seq_PC3_Human2.59730688
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.58681327
12STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.57991191
13SOX2_20726797_ChIP-Seq_SW620_Human2.54168772
14FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.49668079
15AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.48035650
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.46527119
17ZNF263_19887448_ChIP-Seq_K562_Human2.42039561
18EZH2_22144423_ChIP-Seq_EOC_Human2.39797879
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39494032
20ZNF217_24962896_ChIP-Seq_MCF-7_Human2.38671333
21SOX9_24532713_ChIP-Seq_HFSC_Mouse2.33331889
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.25420347
23SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.22225750
24SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.22225750
25FOXO3_23340844_ChIP-Seq_DLD1_Human2.21753734
26ESR1_20079471_ChIP-ChIP_T-47D_Human2.21588922
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16824418
28IGF1R_20145208_ChIP-Seq_DFB_Human2.08429825
29P63_26484246_Chip-Seq_KERATINOCYTES_Human2.08258148
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.07868549
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04958430
32ESR1_21235772_ChIP-Seq_MCF-7_Human2.02936567
33AHR_22903824_ChIP-Seq_MCF-7_Human2.00127251
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.98450604
35P300_19829295_ChIP-Seq_ESCs_Human1.95864794
36GATA3_24758297_ChIP-Seq_MCF-7_Human1.93840902
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92094570
38GATA1_22025678_ChIP-Seq_K562_Human1.89609607
39ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.89189492
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.85935036
41GATA6_25053715_ChIP-Seq_YYC3_Human1.84956656
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.84163086
43GATA4_25053715_ChIP-Seq_YYC3_Human1.81448117
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79014454
45FUS_26573619_Chip-Seq_HEK293_Human1.77572812
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76738128
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75272548
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68992785
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.68207860
50ATF3_27146783_Chip-Seq_COLON_Human1.66241591
51ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.65723567
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64869141
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.64522839
54TAF15_26573619_Chip-Seq_HEK293_Human1.64355366
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.62848821
56BCAT_22108803_ChIP-Seq_LS180_Human1.62661044
57ER_23166858_ChIP-Seq_MCF-7_Human1.61558021
58AR_25329375_ChIP-Seq_VCAP_Human1.59436666
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59410903
60EWS_26573619_Chip-Seq_HEK293_Human1.58630036
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57536241
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52405982
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51863504
64CLOCK_20551151_ChIP-Seq_293T_Human1.51141890
65PKCTHETA_26484144_Chip-Seq_BREAST_Human1.51128435
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.50456308
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50101263
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48554001
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48554001
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48151970
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.46678023
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46628818
73CHD1_26751641_Chip-Seq_LNCaP_Human1.46464791
74CBP_20019798_ChIP-Seq_JUKART_Human1.45293201
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45293201
76NANOG_19829295_ChIP-Seq_ESCs_Human1.43989793
77SOX2_19829295_ChIP-Seq_ESCs_Human1.43989793
78ERG_20517297_ChIP-Seq_VCAP_Human1.43774986
79SMAD4_21799915_ChIP-Seq_A2780_Human1.43660590
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.43145205
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40208980
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.39109209
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38815924
84TCF4_22108803_ChIP-Seq_LS180_Human1.38759607
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38753951
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37262515
87AR_21572438_ChIP-Seq_LNCaP_Human1.36163389
88STAT3_23295773_ChIP-Seq_U87_Human1.35198054
89* FOXA1_25552417_ChIP-Seq_VCAP_Human1.34686558
90RACK7_27058665_Chip-Seq_MCF-7_Human1.34499039
91CDX2_20551321_ChIP-Seq_CACO-2_Human1.33906743
92NCOR_22424771_ChIP-Seq_293T_Human1.33782210
93TCF4_23295773_ChIP-Seq_U87_Human1.32768407
94* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.32315455
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.29543235
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.29147314
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28830961
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28588865
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.28347847
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27684895
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26408663
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25512398
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.25291026
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.25291026
105PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23598720
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22622896
107CJUN_26792858_Chip-Seq_BT549_Human1.22598473
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.22028058
109AR_20517297_ChIP-Seq_VCAP_Human1.21316239
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21207413
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.20903579
112RXR_22108803_ChIP-Seq_LS180_Human1.20102540
113HOXB7_26014856_ChIP-Seq_BT474_Human1.19987623
114* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19521973
115REST_21632747_ChIP-Seq_MESCs_Mouse1.19407933
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18857977
117* TP63_23658742_ChIP-Seq_EP156T_Human1.18478713
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.18174984
119FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17300683
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.17300683
121AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17104750
122CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16068283
123RUNX2_22187159_ChIP-Seq_PCA_Human1.15722094
124TAF2_19829295_ChIP-Seq_ESCs_Human1.15582382
125TP53_22573176_ChIP-Seq_HFKS_Human1.15581932
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14629633
127NANOG_18555785_Chip-Seq_ESCs_Mouse1.14403501
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14091156
129PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.12925055
130KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12783477
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12625574
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12200248
133HTT_18923047_ChIP-ChIP_STHdh_Human1.12012663
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11535769
135HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10739557
136ZNF274_21170338_ChIP-Seq_K562_Hela1.10063817
137CRX_20693478_ChIP-Seq_RETINA_Mouse1.09556343
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09514772
139IRF8_22096565_ChIP-ChIP_GC-B_Human1.08393305
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07694849
141CBX2_27304074_Chip-Seq_ESCs_Mouse1.07595740
142FOXH1_21741376_ChIP-Seq_EPCs_Human1.07103886
143* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.06991939
144FLI1_21867929_ChIP-Seq_TH2_Mouse1.06811334
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05191814
146STAT3_18555785_Chip-Seq_ESCs_Mouse1.04492122
147NANOG_20526341_ChIP-Seq_ESCs_Human1.04437999
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03454714
149P53_22387025_ChIP-Seq_ESCs_Mouse1.03382895
150MYC_19829295_ChIP-Seq_ESCs_Human1.03086728
151FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02659170
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02376483
153PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02323684
154EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00384059
155P53_21459846_ChIP-Seq_SAOS-2_Human0.99243428
156IRF1_19129219_ChIP-ChIP_H3396_Human0.98828856
157LXR_22158963_ChIP-Seq_LIVER_Mouse0.94273182
158* CREB1_26743006_Chip-Seq_LNCaP_Human0.92854553
159PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92771930
160BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.92300893
161* KLF5_25053715_ChIP-Seq_YYC3_Human0.90562234
162RXR_22158963_ChIP-Seq_LIVER_Mouse0.89607379
163FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89091072
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86312954
165FOXA2_19822575_ChIP-Seq_HepG2_Human0.85866773
166ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85394805
167PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84109314
168DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84001023
169GATA2_21666600_ChIP-Seq_HMVEC_Human0.83148211
170ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83002960
171CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82572495
172UBF1/2_26484160_Chip-Seq_HMECs_Human0.82170440
173TP63_22573176_ChIP-Seq_HFKS_Human0.81658090
174PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80861062
175CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78130642
176CDX2_22108803_ChIP-Seq_LS180_Human0.75780672
177FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.75489385
178CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.74687461
179BMI1_23680149_ChIP-Seq_NPCS_Mouse0.73742023
180TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.71771227
181GATA3_21878914_ChIP-Seq_MCF-7_Human0.71549912
182FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.71412072
183AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.71032576
184NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.70186048
185TBX20_22328084_ChIP-Seq_HEART_Mouse0.69518429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.36352053
2MP0002796_impaired_skin_barrier4.87035680
3MP0002166_altered_tumor_susceptibility4.14241693
4MP0005310_abnormal_salivary_gland4.03039267
5MP0003300_gastrointestinal_ulcer3.83015981
6MP0004043_abnormal_pH_regulation3.71001969
7MP0010386_abnormal_urinary_bladder3.44601927
8MP0005647_abnormal_sex_gland3.20662651
9MP0004885_abnormal_endolymph3.10416462
10MP0005275_abnormal_skin_tensile3.07531270
11MP0002006_tumorigenesis3.01521490
12MP0000613_abnormal_salivary_gland2.91741438
13MP0000579_abnormal_nail_morphology2.88424630
14MP0005501_abnormal_skin_physiology2.79611443
15MP0002098_abnormal_vibrissa_morphology2.73786510
16MP0002837_dystrophic_cardiac_calcinosis2.69595986
17MP0003941_abnormal_skin_development2.67644729
18MP0003878_abnormal_ear_physiology2.59526361
19MP0005377_hearing/vestibular/ear_phenot2.59526361
20MP0003195_calcinosis2.59435889
21MP0003011_delayed_dark_adaptation2.39888032
22MP0000569_abnormal_digit_pigmentation2.28559617
23MP0002009_preneoplasia2.23241383
24MP0002095_abnormal_skin_pigmentation2.22347231
25MP0003136_yellow_coat_color2.21165110
26MP0010678_abnormal_skin_adnexa2.20654479
27MP0000647_abnormal_sebaceous_gland2.18705744
28MP0002653_abnormal_ependyma_morphology2.16968549
29MP0001765_abnormal_ion_homeostasis2.13649632
30MP0005174_abnormal_tail_pigmentation2.07238690
31MP0004264_abnormal_extraembryonic_tissu2.06199383
32MP0000537_abnormal_urethra_morphology2.03894106
33MP0001216_abnormal_epidermal_layer2.02530126
34MP0002060_abnormal_skin_morphology2.01917107
35MP0000377_abnormal_hair_follicle2.00311959
36MP0003183_abnormal_peptide_metabolism1.96953477
37MP0000372_irregular_coat_pigmentation1.85060425
38MP0005551_abnormal_eye_electrophysiolog1.79648781
39MP0002102_abnormal_ear_morphology1.79559545
40MP0005451_abnormal_body_composition1.77972908
41MP0004381_abnormal_hair_follicle1.76125088
42MP0001501_abnormal_sleep_pattern1.74725389
43MP0001756_abnormal_urination1.73198942
44MP0003705_abnormal_hypodermis_morpholog1.70966537
45MP0005075_abnormal_melanosome_morpholog1.70358985
46MP0003453_abnormal_keratinocyte_physiol1.69448675
47MP0010771_integument_phenotype1.67869103
48MP0001873_stomach_inflammation1.65572294
49MP0002132_abnormal_respiratory_system1.62991378
50MP0001485_abnormal_pinna_reflex1.61799904
51MP0000427_abnormal_hair_cycle1.59637240
52MP0000015_abnormal_ear_pigmentation1.59033221
53MP0005379_endocrine/exocrine_gland_phen1.58586235
54MP0003646_muscle_fatigue1.57782358
55MP0005171_absent_coat_pigmentation1.56277742
56MP0001188_hyperpigmentation1.54647134
57MP0009046_muscle_twitch1.49642918
58MP0002254_reproductive_system_inflammat1.48522636
59MP0004142_abnormal_muscle_tone1.46429585
60MP0008877_abnormal_DNA_methylation1.45811991
61MP0005646_abnormal_pituitary_gland1.44930092
62MP0005636_abnormal_mineral_homeostasis1.44156558
63MP0000566_synostosis1.43473311
64MP0001984_abnormal_olfaction1.41226292
65MP0006292_abnormal_olfactory_placode1.41138416
66MP0009764_decreased_sensitivity_to1.40883283
67MP0001346_abnormal_lacrimal_gland1.40607092
68MP0006072_abnormal_retinal_apoptosis1.40159386
69MP0000383_abnormal_hair_follicle1.37827594
70MP0008875_abnormal_xenobiotic_pharmacok1.35843599
71MP0010352_gastrointestinal_tract_polyps1.33268007
72MP0000538_abnormal_urinary_bladder1.32629006
73MP0004947_skin_inflammation1.29132064
74MP0005253_abnormal_eye_physiology1.27978778
75MP0002138_abnormal_hepatobiliary_system1.27559583
76MP0001968_abnormal_touch/_nociception1.27161182
77MP0003866_abnormal_defecation1.26519890
78MP0005367_renal/urinary_system_phenotyp1.26428485
79MP0000516_abnormal_urinary_system1.26428485
80MP0005220_abnormal_exocrine_pancreas1.25710408
81MP0002163_abnormal_gland_morphology1.25387985
82MP0008872_abnormal_physiological_respon1.24541745
83MP0005671_abnormal_response_to1.22816977
84MP0009745_abnormal_behavioral_response1.22785199
85MP0003656_abnormal_erythrocyte_physiolo1.21473518
86MP0005058_abnormal_lysosome_morphology1.18296887
87MP0002736_abnormal_nociception_after1.16335830
88MP0002638_abnormal_pupillary_reflex1.15726063
89MP0000467_abnormal_esophagus_morphology1.14488923
90MP0002295_abnormal_pulmonary_circulatio1.14250896
91MP0000762_abnormal_tongue_morphology1.13405446
92MP0003315_abnormal_perineum_morphology1.13016295
93MP0003566_abnormal_cell_adhesion1.12491607
94MP0004185_abnormal_adipocyte_glucose1.11619640
95MP0006054_spinal_hemorrhage1.10005438
96MP0009765_abnormal_xenobiotic_induced1.08725195
97MP0000367_abnormal_coat/_hair1.05643288
98MP0002272_abnormal_nervous_system1.04334050
99MP0002938_white_spotting1.02377019
100MP0009643_abnormal_urine_homeostasis1.01862105
101MP0002909_abnormal_adrenal_gland1.01565498
102MP0009780_abnormal_chondrocyte_physiolo1.01524458
103MP0002148_abnormal_hypersensitivity_rea1.01136776
104MP0001299_abnormal_eye_distance/0.98708484
105MP0004782_abnormal_surfactant_physiolog0.97571260
106MP0001944_abnormal_pancreas_morphology0.97075867
107MP0004147_increased_porphyrin_level0.94262581
108MP0008789_abnormal_olfactory_epithelium0.94059917
109MP0009931_abnormal_skin_appearance0.93619107
110MP0003880_abnormal_central_pattern0.89238688
111MP0002876_abnormal_thyroid_physiology0.88827791
112MP0002064_seizures0.87456908
113MP0000627_abnormal_mammary_gland0.87421760
114MP0004742_abnormal_vestibular_system0.87355710
115MP0001970_abnormal_pain_threshold0.86797524
116MP0004133_heterotaxia0.85318087
117MP0002136_abnormal_kidney_physiology0.85298735
118MP0003724_increased_susceptibility_to0.84007050
119MP0000230_abnormal_systemic_arterial0.82546806
120MP0005389_reproductive_system_phenotype0.81505996
121MP0010155_abnormal_intestine_physiology0.80990551
122MP0002733_abnormal_thermal_nociception0.79364376
123MP0005645_abnormal_hypothalamus_physiol0.79352356
124MP0001191_abnormal_skin_condition0.78665734
125MP0003890_abnormal_embryonic-extraembry0.78126802
126MP0006276_abnormal_autonomic_nervous0.77834469
127MP0001986_abnormal_taste_sensitivity0.77806995
128MP0002139_abnormal_hepatobiliary_system0.77672116
129MP0001324_abnormal_eye_pigmentation0.77445093
130MP0000685_abnormal_immune_system0.76589560
131MP0002572_abnormal_emotion/affect_behav0.76301515
132MP0002693_abnormal_pancreas_physiology0.76162779
133MP0005076_abnormal_cell_differentiation0.75755636
134MP0003045_fibrosis0.75625105
135MP0000631_abnormal_neuroendocrine_gland0.75415324
136MP0003787_abnormal_imprinting0.75288824
137MP0001905_abnormal_dopamine_level0.74641233
138MP0001486_abnormal_startle_reflex0.73975140
139MP0000026_abnormal_inner_ear0.73665426
140MP0005084_abnormal_gallbladder_morpholo0.72336261
141MP0002111_abnormal_tail_morphology0.72102707
142MP0005365_abnormal_bile_salt0.70252242
143MP0001919_abnormal_reproductive_system0.69471366
144MP0005167_abnormal_blood-brain_barrier0.69427357
145MP0005023_abnormal_wound_healing0.67920893
146MP0003638_abnormal_response/metabolism_0.66819610
147MP0002896_abnormal_bone_mineralization0.66411591
148MP0003137_abnormal_impulse_conducting0.64984451
149MP0002229_neurodegeneration0.63350157
150MP0004215_abnormal_myocardial_fiber0.62953887
151MP0000470_abnormal_stomach_morphology0.61623588
152MP0005332_abnormal_amino_acid0.60607988
153MP0002877_abnormal_melanocyte_morpholog0.58446447
154MP0000534_abnormal_ureter_morphology0.58372158
155MP0000681_abnormal_thyroid_gland0.56731252
156MP0009379_abnormal_foot_pigmentation0.55801908
157MP0003936_abnormal_reproductive_system0.54650698
158MP0001243_abnormal_dermal_layer0.53011201
159MP0003959_abnormal_lean_body0.52564876
160MP0002277_abnormal_respiratory_mucosa0.52555890
161MP0002234_abnormal_pharynx_morphology0.52191262
162MP0004145_abnormal_muscle_electrophysio0.51390400
163MP0009384_cardiac_valve_regurgitation0.50405355
164MP0000477_abnormal_intestine_morphology0.49502179
165MP0003186_abnormal_redox_activity0.48654123
166MP0005166_decreased_susceptibility_to0.48271943
167MP0008438_abnormal_cutaneous_collagen0.48200302
168MP0002135_abnormal_kidney_morphology0.46941871
169MP0003868_abnormal_feces_composition0.46171359
170MP0001784_abnormal_fluid_regulation0.45403895

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cochlea (HP:0000375)7.04351108
2Woolly hair (HP:0002224)5.60227146
3Hypotrichosis (HP:0001006)5.16792900
4Pili torti (HP:0003777)5.00645202
5Right ventricular cardiomyopathy (HP:0011663)4.94721781
6Morphological abnormality of the inner ear (HP:0011390)4.74562228
7Vacuolated lymphocytes (HP:0001922)4.64842012
8Abnormality of nail color (HP:0100643)4.55280327
9Abnormality of the axillary hair (HP:0100134)4.31592877
10Abnormality of secondary sexual hair (HP:0009888)4.31592877
11Increased IgE level (HP:0003212)4.04911661
12Palmoplantar hyperkeratosis (HP:0000972)3.97590297
13Onycholysis (HP:0001806)3.93814288
14Plantar hyperkeratosis (HP:0007556)3.93238691
15Congenital ichthyosiform erythroderma (HP:0007431)3.86215292
16Palmar hyperkeratosis (HP:0010765)3.69106999
17Pancreatic cysts (HP:0001737)3.62962211
18Abnormality of the intrinsic pathway (HP:0010989)3.62055290
19Lip pit (HP:0100267)3.47555215
20Abnormal hair laboratory examination (HP:0003328)3.38603267
21Furrowed tongue (HP:0000221)3.38341968
22Congenital stationary night blindness (HP:0007642)3.33603843
23True hermaphroditism (HP:0010459)3.26794600
24Testicular atrophy (HP:0000029)3.26109292
25Dysostosis multiplex (HP:0000943)3.26104026
26Pancreatic fibrosis (HP:0100732)3.19430650
27Molar tooth sign on MRI (HP:0002419)3.11433586
28Abnormality of midbrain morphology (HP:0002418)3.11433586
29Oral leukoplakia (HP:0002745)3.10795533
30Hypomagnesemia (HP:0002917)3.07996866
31Curly hair (HP:0002212)3.02721652
32Gangrene (HP:0100758)3.01294675
33Nail dystrophy (HP:0008404)2.92268569
34Fragile nails (HP:0001808)2.90729742
35Nephronophthisis (HP:0000090)2.86000875
36Mucopolysacchariduria (HP:0008155)2.85702119
37Urinary glycosaminoglycan excretion (HP:0003541)2.85702119
38Achilles tendon contracture (HP:0001771)2.83833198
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.77217960
40Natal tooth (HP:0000695)2.75410090
41Corneal erosion (HP:0200020)2.73596977
42Ectropion (HP:0000656)2.71076863
43Widely patent fontanelles and sutures (HP:0004492)2.70387000
44Potter facies (HP:0002009)2.68352330
45Facial shape deformation (HP:0011334)2.68352330
46Milia (HP:0001056)2.64146314
47Erythema (HP:0010783)2.62621458
48Abnormality of magnesium homeostasis (HP:0004921)2.62616496
49Hypoplasia of the uterus (HP:0000013)2.60794709
50Parakeratosis (HP:0001036)2.58201618
51Subcapsular cataract (HP:0000523)2.58063935
52Abnormality of the renal cortex (HP:0011035)2.54855969
53Abnormality of polysaccharide metabolism (HP:0011012)2.54545866
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.54545866
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.54545866
56Abnormality of the Achilles tendon (HP:0005109)2.53992449
57Conjunctival hamartoma (HP:0100780)2.53863166
58Thick nail (HP:0001805)2.53550932
59Hyperglycinuria (HP:0003108)2.52052351
60Hypohidrosis (HP:0000966)2.50781202
61Abnormality of the renal medulla (HP:0100957)2.50421598
62Type II lissencephaly (HP:0007260)2.47994407
63Myopathic facies (HP:0002058)2.43236676
64Hyporeflexia of lower limbs (HP:0002600)2.40982007
65Intention tremor (HP:0002080)2.39283013
66Medial flaring of the eyebrow (HP:0010747)2.38983463
67Brittle hair (HP:0002299)2.37920397
68Abnormal drinking behavior (HP:0030082)2.33410424
69Polydipsia (HP:0001959)2.33410424
70Congenital, generalized hypertrichosis (HP:0004540)2.33333759
71Hydroxyprolinuria (HP:0003080)2.31118425
72Abnormality of proline metabolism (HP:0010907)2.31118425
73Hypoplastic labia majora (HP:0000059)2.30413539
74Absent hair (HP:0002298)2.29766357
75Sparse eyelashes (HP:0000653)2.29251437
76Popliteal pterygium (HP:0009756)2.29147457
77Tubular atrophy (HP:0000092)2.28802164
78Abnormality of hair growth rate (HP:0011363)2.28766494
79Slow-growing hair (HP:0002217)2.28766494
80Hyperventilation (HP:0002883)2.25529917
81Duplicated collecting system (HP:0000081)2.25012611
82Hypoplasia of the pons (HP:0012110)2.23204396
83Male infertility (HP:0003251)2.22041504
84Advanced eruption of teeth (HP:0006288)2.21744264
85Conical tooth (HP:0000698)2.20385872
86Erythroderma (HP:0001019)2.17506808
87Abnormality of the renal collecting system (HP:0004742)2.17362211
88Abnormal rod and cone electroretinograms (HP:0008323)2.15880693
89Abolished electroretinogram (ERG) (HP:0000550)2.15704132
90Rectal prolapse (HP:0002035)2.14199272
91Pendular nystagmus (HP:0012043)2.13381021
92Cystic liver disease (HP:0006706)2.12859015
93Decreased central vision (HP:0007663)2.10352432
94Decreased circulating renin level (HP:0003351)2.10318937
95Agitation (HP:0000713)2.09777266
96Abnormal blistering of the skin (HP:0008066)2.09048388
97Aplasia involving bones of the extremities (HP:0009825)2.08144542
98Aplasia involving bones of the upper limbs (HP:0009823)2.08144542
99Aplasia of the phalanges of the hand (HP:0009802)2.08144542
100Inability to walk (HP:0002540)2.07519139
101Stomatitis (HP:0010280)2.07457109
102Attenuation of retinal blood vessels (HP:0007843)2.06710220
103Sparse lateral eyebrow (HP:0005338)2.03549021
104Dynein arm defect of respiratory motile cilia (HP:0012255)2.01595274
105Absent/shortened dynein arms (HP:0200106)2.01595274
106Abnormality of the labia majora (HP:0012881)2.01452226
107Reduced antithrombin III activity (HP:0001976)2.01378717
108Alopecia of scalp (HP:0002293)2.00609350
109Large for gestational age (HP:0001520)2.00071076
110Exocrine pancreatic insufficiency (HP:0001738)1.98976019
111Coxa valga (HP:0002673)1.98353792
112Aortic aneurysm (HP:0004942)1.97900597
113Aplasia/hypoplasia of the uterus (HP:0008684)1.95577179
114Abnormality of the pons (HP:0007361)1.93310573
115Barrel-shaped chest (HP:0001552)1.93171271
116Stomach cancer (HP:0012126)1.92228936
117Increased corneal curvature (HP:0100692)1.92085159
118Keratoconus (HP:0000563)1.92085159
119Mildly elevated creatine phosphokinase (HP:0008180)1.90176871
120Gait imbalance (HP:0002141)1.89210459
121Ulnar deviation of the wrist (HP:0003049)1.89002537
122Hypothermia (HP:0002045)1.88699995
123Amelogenesis imperfecta (HP:0000705)1.88691541
124Fair hair (HP:0002286)1.88645441
125Laryngomalacia (HP:0001601)1.88299291
126Abnormality of serine family amino acid metabolism (HP:0010894)1.87758656
127Abnormality of glycine metabolism (HP:0010895)1.87758656
128Chronic hepatic failure (HP:0100626)1.87097604
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86259647
130Progressive inability to walk (HP:0002505)1.86182163
131Absent eyelashes (HP:0000561)1.85334613
132Beaking of vertebral bodies (HP:0004568)1.84316237
133Biliary tract neoplasm (HP:0100574)1.83579775
134Polar cataract (HP:0010696)1.83577646
135Abnormal protein glycosylation (HP:0012346)1.83304630
136Abnormal glycosylation (HP:0012345)1.83304630
137Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83304630
138Abnormal protein N-linked glycosylation (HP:0012347)1.83304630
139Congenital primary aphakia (HP:0007707)1.81383415
140Neck muscle weakness (HP:0000467)1.81103842
141Congenital hepatic fibrosis (HP:0002612)1.80910802
142Polyuria (HP:0000103)1.80586124
143Pruritus (HP:0000989)1.79988422
144Palmoplantar keratoderma (HP:0000982)1.78598023
145Hamartoma of the eye (HP:0010568)1.78454426
146Lissencephaly (HP:0001339)1.78351116
147Acanthosis nigricans (HP:0000956)1.77436548
148Abnormal foot bone ossification (HP:0010675)1.76474353
149Gaze-evoked nystagmus (HP:0000640)1.76116440
150Upper limb muscle weakness (HP:0003484)1.74410501
151Concave nail (HP:0001598)1.73549798
152Methylmalonic acidemia (HP:0002912)1.73017030
153Follicular hyperkeratosis (HP:0007502)1.72237182
154Pustule (HP:0200039)1.72111336
155Aplasia/Hypoplasia of the tongue (HP:0010295)1.72075920
156Hemiparesis (HP:0001269)1.71962795
157Widely spaced teeth (HP:0000687)1.71623379
158Nephrogenic diabetes insipidus (HP:0009806)1.70672532
159Abnormality of alanine metabolism (HP:0010916)1.69574121
160Hyperalaninemia (HP:0003348)1.69574121
161Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69574121
162Anencephaly (HP:0002323)1.67794963
163Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67145268
164Renal cortical cysts (HP:0000803)1.66803542
165Febrile seizures (HP:0002373)1.66092277
166Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65630459
167Sclerocornea (HP:0000647)1.64720995

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT36.42339480
2MST45.36806709
3FRK5.17369611
4TAOK34.67979251
5ERN14.59075758
6ADRBK23.70176552
7LATS13.63874001
8BMPR1B3.05655948
9ACVR1B2.90535205
10MAPKAPK32.75773428
11EEF2K2.62628733
12MAP3K22.62051496
13TGFBR12.52784551
14ZAK2.47338865
15BCKDK2.45553131
16TXK2.42987109
17EPHA22.26949375
18WNK32.15967435
19FER2.15526932
20PINK12.15243024
21MAP4K22.13398235
22SCYL22.10099085
23SIK11.97927792
24TLK11.97554243
25WNK41.96411802
26GRK71.81791686
27RPS6KB21.80887950
28MAP3K41.75430837
29TNIK1.62696633
30MST1R1.53713297
31MAPK131.51504020
32MAP3K31.39914567
33PDK21.39825511
34TNK21.34711021
35PIK3CG1.34589121
36IKBKB1.32085693
37DAPK21.30764050
38CASK1.29975494
39INSRR1.23080937
40OXSR11.20029030
41NUAK11.16875188
42JAK31.15391016
43IRAK11.14952336
44MYLK1.12667259
45PTK61.11228060
46LRRK21.11157946
47EIF2AK31.09392601
48DYRK21.03750229
49PAK31.01858360
50TRIM280.96833851
51PRKCG0.96486203
52MKNK20.96378945
53MET0.96131931
54TRIB30.95100504
55PNCK0.94508754
56MAP2K60.93303402
57TESK10.93246489
58TTN0.91310656
59PDGFRA0.87938371
60CAMKK20.86969673
61LMTK20.85914208
62TRPM70.85428972
63STK240.84725804
64STK100.83126057
65PRKCI0.81972453
66MAP2K70.79469620
67TAF10.76085193
68PLK20.74346203
69TIE10.73537642
70GRK10.73269123
71MARK10.73006742
72NEK60.72640013
73PKN10.72208467
74PIK3CA0.71618778
75NME10.70282360
76GRK50.70158605
77CSNK1G20.69644063
78KIT0.69408798
79JAK20.69033120
80CHUK0.68912310
81RPS6KA20.67930312
82JAK10.66379296
83MAPK150.64969184
84STK30.64793111
85HIPK20.64030455
86IKBKE0.63352141
87ERBB30.62868371
88MAP2K20.62389132
89TGFBR20.62388471
90NLK0.61537329
91STK390.59934765
92IRAK30.59876963
93CSNK1G30.59058129
94NTRK30.58607460
95CSNK1A1L0.58459936
96EPHB10.57326459
97CSNK1G10.56393471
98MUSK0.55630113
99VRK10.52786952
100PTK2B0.52537073
101PHKG10.51983247
102PHKG20.51983247
103TEC0.51678779
104EPHA30.51535843
105NME20.51200648
106NTRK20.48573820
107FLT30.48102791
108NTRK10.45685722
109PKN20.45012428
110ABL20.44535295
111STK110.44025246
112STK38L0.43969946
113BRSK20.43819741
114MATK0.41427610
115PRKACA0.40961161
116STK380.40741672
117MAP2K40.40262655
118SGK4940.40138616
119SGK2230.40138616
120BCR0.39650081
121EPHB20.39580441
122CAMK2A0.39271414
123BTK0.39000913
124CSF1R0.38353932
125ABL10.38322789
126DYRK30.38091504
127ITK0.37962657
128SYK0.36642681
129LATS20.36613467
130IRAK40.35633594
131MAP3K10.34078218
132DMPK0.34058741
133PRKAA20.34049080
134MAP2K30.33082893
135MAP3K60.32556604
136SGK20.32535259
137PRKCE0.31518584
138FGFR30.31452393
139RPS6KB10.31067011
140PDPK10.31049655
141PRKD10.29649152
142IGF1R0.29549809
143PDK10.29514341
144ADRBK10.29340753
145PAK20.29310930
146FGFR10.28761888
147PRKCA0.28665365
148ROCK10.28222599
149TAOK10.28036296
150CDC42BPA0.27879169
151CSNK1D0.27708642
152RPS6KA50.27210928
153TESK20.27164774
154RPS6KA10.26001975
155ROCK20.25022048
156MAPKAPK50.24942446
157RPS6KC10.24837801
158RPS6KL10.24837801
159MTOR0.22802847
160FGFR20.22028912
161PRKCQ0.21868740
162RET0.19575578
163PTK20.19561947
164MAP3K80.19439105
165PRKD20.19131294
166MAPKAPK20.19102242
167LIMK10.15545818
168FYN0.15070599
169TYK20.12845331
170RPS6KA60.12354226
171MAP3K70.11772037
172CSNK2A20.11614066
173CSNK1A10.09620833
174PDGFRB0.09097045
175PRKAA10.09045638
176DDR20.08726259

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.65699644
2Protein export_Homo sapiens_hsa030604.78232167
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.66658121
4Phototransduction_Homo sapiens_hsa047443.49436120
5Sulfur metabolism_Homo sapiens_hsa009203.43504088
6Vibrio cholerae infection_Homo sapiens_hsa051102.68029882
7N-Glycan biosynthesis_Homo sapiens_hsa005102.54649691
8Other glycan degradation_Homo sapiens_hsa005112.51348183
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.20305371
10Nitrogen metabolism_Homo sapiens_hsa009102.12726774
11Sphingolipid metabolism_Homo sapiens_hsa006001.97056672
12Prostate cancer_Homo sapiens_hsa052151.96883043
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.94299703
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92310461
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88214706
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84869081
17Asthma_Homo sapiens_hsa053101.80904094
18Collecting duct acid secretion_Homo sapiens_hsa049661.80855005
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68755184
20Butanoate metabolism_Homo sapiens_hsa006501.63105952
21Nicotine addiction_Homo sapiens_hsa050331.62790832
22Tryptophan metabolism_Homo sapiens_hsa003801.60848799
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55472609
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.53428518
25Oxidative phosphorylation_Homo sapiens_hsa001901.47914512
26Bladder cancer_Homo sapiens_hsa052191.44948944
27Tight junction_Homo sapiens_hsa045301.44213408
28Endometrial cancer_Homo sapiens_hsa052131.43723198
29Caffeine metabolism_Homo sapiens_hsa002321.42246269
30Lysosome_Homo sapiens_hsa041421.37281231
31Renin-angiotensin system_Homo sapiens_hsa046141.35621594
32Selenocompound metabolism_Homo sapiens_hsa004501.35080239
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34677453
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32086364
35Ovarian steroidogenesis_Homo sapiens_hsa049131.29665241
36Serotonergic synapse_Homo sapiens_hsa047261.28007876
37Linoleic acid metabolism_Homo sapiens_hsa005911.22298147
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21191874
39Rheumatoid arthritis_Homo sapiens_hsa053231.19246469
40Hepatitis C_Homo sapiens_hsa051601.16800832
41Fructose and mannose metabolism_Homo sapiens_hsa000511.15946044
42Adherens junction_Homo sapiens_hsa045201.14935380
43Olfactory transduction_Homo sapiens_hsa047401.12179285
44Staphylococcus aureus infection_Homo sapiens_hsa051501.10464324
45Taste transduction_Homo sapiens_hsa047421.08221526
46Morphine addiction_Homo sapiens_hsa050321.04356071
47Arachidonic acid metabolism_Homo sapiens_hsa005901.02936882
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02648602
49Allograft rejection_Homo sapiens_hsa053301.02105673
50Dorso-ventral axis formation_Homo sapiens_hsa043200.99648878
51Thyroid hormone synthesis_Homo sapiens_hsa049180.98708136
52Basal transcription factors_Homo sapiens_hsa030220.97702930
53Graft-versus-host disease_Homo sapiens_hsa053320.97452837
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.96323693
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.95942003
56Glutamatergic synapse_Homo sapiens_hsa047240.94899310
57Retinol metabolism_Homo sapiens_hsa008300.94875916
58Amoebiasis_Homo sapiens_hsa051460.93677386
59Type I diabetes mellitus_Homo sapiens_hsa049400.93549676
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.91462432
61ErbB signaling pathway_Homo sapiens_hsa040120.91449914
62Autoimmune thyroid disease_Homo sapiens_hsa053200.88789491
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88451643
64ABC transporters_Homo sapiens_hsa020100.88290052
65Chemical carcinogenesis_Homo sapiens_hsa052040.87955440
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.86207187
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86065740
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85360322
69Circadian rhythm_Homo sapiens_hsa047100.85355173
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84608282
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84477559
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83882096
73Circadian entrainment_Homo sapiens_hsa047130.83365965
74Peroxisome_Homo sapiens_hsa041460.82051744
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81092152
76Fatty acid elongation_Homo sapiens_hsa000620.80829444
77Sulfur relay system_Homo sapiens_hsa041220.79889561
78Long-term depression_Homo sapiens_hsa047300.79509662
79Glioma_Homo sapiens_hsa052140.79463994
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79263097
81Parkinsons disease_Homo sapiens_hsa050120.75517640
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75473407
83Insulin resistance_Homo sapiens_hsa049310.74804647
84Inositol phosphate metabolism_Homo sapiens_hsa005620.74262226
85Small cell lung cancer_Homo sapiens_hsa052220.73690557
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.73012815
87Glycerolipid metabolism_Homo sapiens_hsa005610.72920614
88Arginine biosynthesis_Homo sapiens_hsa002200.72800804
89ECM-receptor interaction_Homo sapiens_hsa045120.72509978
90Homologous recombination_Homo sapiens_hsa034400.72455762
91GABAergic synapse_Homo sapiens_hsa047270.71669078
92Melanoma_Homo sapiens_hsa052180.70891081
93Protein digestion and absorption_Homo sapiens_hsa049740.70537618
94Salivary secretion_Homo sapiens_hsa049700.70348412
95Focal adhesion_Homo sapiens_hsa045100.69615106
96Fanconi anemia pathway_Homo sapiens_hsa034600.69488166
97Regulation of autophagy_Homo sapiens_hsa041400.69313322
98Vitamin digestion and absorption_Homo sapiens_hsa049770.69297123
99Non-small cell lung cancer_Homo sapiens_hsa052230.68334841
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67660804
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66744058
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.65061191
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.64696019
104Ribosome_Homo sapiens_hsa030100.64485135
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63130931
106Synaptic vesicle cycle_Homo sapiens_hsa047210.63089961
107mTOR signaling pathway_Homo sapiens_hsa041500.62979439
108Thyroid cancer_Homo sapiens_hsa052160.62966286
109Acute myeloid leukemia_Homo sapiens_hsa052210.62959790
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62666315
111Primary immunodeficiency_Homo sapiens_hsa053400.61149885
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59374738
113Estrogen signaling pathway_Homo sapiens_hsa049150.59286566
114Hippo signaling pathway_Homo sapiens_hsa043900.58798786
115Arginine and proline metabolism_Homo sapiens_hsa003300.58706169
116Pancreatic secretion_Homo sapiens_hsa049720.58661586
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57745781
118Calcium signaling pathway_Homo sapiens_hsa040200.57116889
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57107965
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56273528
121Fat digestion and absorption_Homo sapiens_hsa049750.54328476
122Antigen processing and presentation_Homo sapiens_hsa046120.53363933
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52489639
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51743048
125Alzheimers disease_Homo sapiens_hsa050100.50243791
126Wnt signaling pathway_Homo sapiens_hsa043100.49152335
127AMPK signaling pathway_Homo sapiens_hsa041520.48964989
128Choline metabolism in cancer_Homo sapiens_hsa052310.47977028
129Histidine metabolism_Homo sapiens_hsa003400.46486192
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45455260
131Propanoate metabolism_Homo sapiens_hsa006400.45348168
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.44641337
133Hematopoietic cell lineage_Homo sapiens_hsa046400.44247469
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44132670
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.43996354
136Prolactin signaling pathway_Homo sapiens_hsa049170.43878077
137Dopaminergic synapse_Homo sapiens_hsa047280.42889402
138TGF-beta signaling pathway_Homo sapiens_hsa043500.42841158
139RNA polymerase_Homo sapiens_hsa030200.42657001
140FoxO signaling pathway_Homo sapiens_hsa040680.42003339
141Pathways in cancer_Homo sapiens_hsa052000.41970722
142Proteoglycans in cancer_Homo sapiens_hsa052050.41656078
143Pancreatic cancer_Homo sapiens_hsa052120.41652163
144Endocytosis_Homo sapiens_hsa041440.41278285
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41090520
146beta-Alanine metabolism_Homo sapiens_hsa004100.40920153
147NF-kappa B signaling pathway_Homo sapiens_hsa040640.40756611
148Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40651551
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40460796
150Renin secretion_Homo sapiens_hsa049240.39685963
151RNA degradation_Homo sapiens_hsa030180.38547505
152Steroid biosynthesis_Homo sapiens_hsa001000.38071024
153Ether lipid metabolism_Homo sapiens_hsa005650.37731296
154Cardiac muscle contraction_Homo sapiens_hsa042600.37672651
155Metabolic pathways_Homo sapiens_hsa011000.36206003
156Gap junction_Homo sapiens_hsa045400.35996787
157Oxytocin signaling pathway_Homo sapiens_hsa049210.33972079
158Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32288192
159Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32209573
160Huntingtons disease_Homo sapiens_hsa050160.32151092
161PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31686513
162Phagosome_Homo sapiens_hsa041450.31586277
163Insulin secretion_Homo sapiens_hsa049110.29367293
164Chronic myeloid leukemia_Homo sapiens_hsa052200.28936381
165Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28871589
166Mineral absorption_Homo sapiens_hsa049780.28774598
167Cocaine addiction_Homo sapiens_hsa050300.27073386
168Insulin signaling pathway_Homo sapiens_hsa049100.26065154
169Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25616153
170Melanogenesis_Homo sapiens_hsa049160.24927353
171VEGF signaling pathway_Homo sapiens_hsa043700.24565077
172Fatty acid degradation_Homo sapiens_hsa000710.24323269

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