GSDMC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1secondary metabolite biosynthetic process (GO:0044550)9.63451599
2keratinocyte differentiation (GO:0030216)7.81100160
3ectoderm development (GO:0007398)7.58097255
4peptide cross-linking (GO:0018149)7.27206153
5intermediate filament organization (GO:0045109)6.99772902
6multicellular organismal water homeostasis (GO:0050891)6.59152626
7bundle of His cell to Purkinje myocyte communication (GO:0086069)6.08421550
8epidermal cell differentiation (GO:0009913)5.90596831
9epidermis development (GO:0008544)5.82394386
10water homeostasis (GO:0030104)5.61312106
11sphingoid metabolic process (GO:0046519)5.19691192
12fatty acid elongation (GO:0030497)5.14912120
13keratinocyte development (GO:0003334)5.01173625
14intermediate filament cytoskeleton organization (GO:0045104)4.99314857
15keratinocyte proliferation (GO:0043616)4.93933202
16sphingosine metabolic process (GO:0006670)4.92848136
17long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.92547237
18fatty-acyl-CoA biosynthetic process (GO:0046949)4.83019035
19intermediate filament-based process (GO:0045103)4.82273231
20skin morphogenesis (GO:0043589)4.81023653
21long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.77363860
22negative regulation of keratinocyte proliferation (GO:0010839)4.56385548
23diol metabolic process (GO:0034311)4.52260606
24behavioral response to nicotine (GO:0035095)4.50948612
25linoleic acid metabolic process (GO:0043651)4.42557679
26tyrosine metabolic process (GO:0006570)4.34152270
27acyl-CoA biosynthetic process (GO:0071616)4.24847111
28thioester biosynthetic process (GO:0035384)4.24847111
29fatty-acyl-CoA metabolic process (GO:0035337)4.19909796
30phosphatidylinositol acyl-chain remodeling (GO:0036149)3.82849111
31phenol-containing compound biosynthetic process (GO:0046189)3.72636518
32kynurenine metabolic process (GO:0070189)3.70419177
33long-chain fatty acid biosynthetic process (GO:0042759)3.49951362
34negative regulation of cell fate specification (GO:0009996)3.49502105
35pattern specification involved in kidney development (GO:0061004)3.47725738
36regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.44768245
37establishment of tissue polarity (GO:0007164)3.42332158
38establishment of planar polarity (GO:0001736)3.42332158
39L-fucose catabolic process (GO:0042355)3.42302875
40fucose catabolic process (GO:0019317)3.42302875
41L-fucose metabolic process (GO:0042354)3.42302875
42regulation of chemokine secretion (GO:0090196)3.39753120
43secondary metabolic process (GO:0019748)3.38686242
44oligosaccharide biosynthetic process (GO:0009312)3.33946250
45regulation of keratinocyte differentiation (GO:0045616)3.28294836
46interferon-gamma secretion (GO:0072643)3.27851667
47positive regulation of respiratory burst (GO:0060267)3.26590746
48detection of light stimulus involved in sensory perception (GO:0050962)3.25880654
49detection of light stimulus involved in visual perception (GO:0050908)3.25880654
50developmental pigmentation (GO:0048066)3.25271731
51lateral sprouting from an epithelium (GO:0060601)3.23335749
52pyrimidine-containing compound transmembrane transport (GO:0072531)3.22283541
53positive regulation of epidermis development (GO:0045684)3.21507917
54indolalkylamine metabolic process (GO:0006586)3.15229109
55platelet dense granule organization (GO:0060155)3.13322742
56positive regulation of chemokine secretion (GO:0090197)3.13020781
57regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.12919975
58positive regulation of epidermal cell differentiation (GO:0045606)3.11398641
59polarized epithelial cell differentiation (GO:0030859)3.10561723
60regulation of clathrin-mediated endocytosis (GO:2000369)3.10476465
61cell-substrate junction assembly (GO:0007044)3.09699433
62response to phenylpropanoid (GO:0080184)3.08430567
63indole-containing compound catabolic process (GO:0042436)3.06832967
64indolalkylamine catabolic process (GO:0046218)3.06832967
65tryptophan catabolic process (GO:0006569)3.06832967
66mammary gland epithelial cell differentiation (GO:0060644)3.05564926
67phosphatidylserine acyl-chain remodeling (GO:0036150)3.05062674
68ketone body metabolic process (GO:1902224)3.02622891
69transepithelial transport (GO:0070633)2.98847572
70regulation of cardioblast differentiation (GO:0051890)2.96163905
71parturition (GO:0007567)2.95978152
72adhesion of symbiont to host cell (GO:0044650)2.95527711
73virion attachment to host cell (GO:0019062)2.95527711
74cornea development in camera-type eye (GO:0061303)2.95250569
75response to pheromone (GO:0019236)2.91930654
76phosphatidylserine metabolic process (GO:0006658)2.91864926
77protein K11-linked deubiquitination (GO:0035871)2.85179957
78ubiquinone biosynthetic process (GO:0006744)2.83063572
79regulation of epidermis development (GO:0045682)2.83060114
80regulation of heart rate by cardiac conduction (GO:0086091)2.79682398
81magnesium ion transport (GO:0015693)2.78590188
82myotube differentiation (GO:0014902)2.76168360
83ventricular cardiac muscle cell action potential (GO:0086005)2.75633075
84copper ion transport (GO:0006825)2.74325988
85phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.72218520
86regulation of keratinocyte proliferation (GO:0010837)2.71333756
87one-carbon compound transport (GO:0019755)2.69769277
88negative regulation of epidermal cell differentiation (GO:0045605)2.69430541
89water-soluble vitamin biosynthetic process (GO:0042364)2.67535943
90piRNA metabolic process (GO:0034587)2.66858323
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65888518
92mannosylation (GO:0097502)2.64929898
93folic acid transport (GO:0015884)2.64783992
94viral transcription (GO:0019083)2.64742363
95adhesion of symbiont to host (GO:0044406)2.63951664
96phospholipid catabolic process (GO:0009395)2.63771432
97ubiquinone metabolic process (GO:0006743)2.63616121
98regulation of endothelial cell chemotaxis (GO:2001026)2.62457413
99preassembly of GPI anchor in ER membrane (GO:0016254)2.62312473
100regulation of ruffle assembly (GO:1900027)2.60581467
101triglyceride biosynthetic process (GO:0019432)2.60021981
102glucosamine-containing compound catabolic process (GO:1901072)2.59790341
103neutral lipid biosynthetic process (GO:0046460)2.58907382
104acylglycerol biosynthetic process (GO:0046463)2.58907382
105regulation of phospholipase A2 activity (GO:0032429)2.58523296
106skin development (GO:0043588)2.57961426
107primary alcohol catabolic process (GO:0034310)2.57075829
108regulation of mesoderm development (GO:2000380)2.56611536
109cellular ketone body metabolic process (GO:0046950)2.55860429
110detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55762128
111epithelium development (GO:0060429)2.55729539
112regulation of memory T cell differentiation (GO:0043380)2.55646687
113tryptophan metabolic process (GO:0006568)2.55278198
114carnitine shuttle (GO:0006853)2.53274924
115negative regulation of cell fate commitment (GO:0010454)2.52192952
116regulation of epidermal cell differentiation (GO:0045604)2.51827788
117DNA deamination (GO:0045006)2.51814076
118translational termination (GO:0006415)2.51648675
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51479767
120glycerophospholipid catabolic process (GO:0046475)2.51261736
121positive regulation of p38MAPK cascade (GO:1900745)2.51103523
122intestinal epithelial cell development (GO:0060576)2.50207606
123regulation of sequestering of triglyceride (GO:0010889)2.48088355
124tooth mineralization (GO:0034505)2.47936355
125gap junction assembly (GO:0016264)2.46804198
126regulation of somitogenesis (GO:0014807)2.43788135
127pigment biosynthetic process (GO:0046148)2.43596704
128positive regulation of sodium ion transmembrane transport (GO:1902307)2.42752754
129eyelid development in camera-type eye (GO:0061029)2.41350668
130phosphatidylcholine acyl-chain remodeling (GO:0036151)2.41302458
131phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.40454590
132atrioventricular valve morphogenesis (GO:0003181)2.40406703
133negative regulation of telomere maintenance (GO:0032205)2.39834537
134positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.39617883
135GPI anchor metabolic process (GO:0006505)2.38971677
136multicellular organism reproduction (GO:0032504)2.38180982
137negative regulation of stress fiber assembly (GO:0051497)2.37746905
138cellular biogenic amine catabolic process (GO:0042402)2.37330717
139amine catabolic process (GO:0009310)2.37330717
140localization within membrane (GO:0051668)2.36506126
141ethanol metabolic process (GO:0006067)2.35893825
142membrane budding (GO:0006900)2.33270672
143cardiac conduction (GO:0061337)2.32092399
144indole-containing compound metabolic process (GO:0042430)2.31498093
145action potential (GO:0001508)2.31444708
146regulation of triglyceride biosynthetic process (GO:0010866)2.31384852
147protein localization to cilium (GO:0061512)2.30784799
148ceramide biosynthetic process (GO:0046513)2.29709697
149somite rostral/caudal axis specification (GO:0032525)2.27692272
150male meiosis I (GO:0007141)2.27469722
151axoneme assembly (GO:0035082)2.27249327
152photoreceptor cell maintenance (GO:0045494)2.27060949
153negative regulation of epidermis development (GO:0045683)2.25647442
154cardiac muscle cell action potential (GO:0086001)2.25365823
155phosphatidylglycerol metabolic process (GO:0046471)2.24991126
156neuronal action potential (GO:0019228)2.24718157
157behavioral response to ethanol (GO:0048149)2.23745131
158alditol phosphate metabolic process (GO:0052646)2.23667788
159keratinization (GO:0031424)15.3282922
160desmosome organization (GO:0002934)14.1356245
161melanin biosynthetic process (GO:0042438)11.7644309
162molting cycle (GO:0042303)11.3857635
163hair cycle (GO:0042633)11.3857635
164establishment of skin barrier (GO:0061436)10.8946826
165melanin metabolic process (GO:0006582)10.5227043
166hemidesmosome assembly (GO:0031581)10.3456352
167regulation of water loss via skin (GO:0033561)10.0398445

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.59219441
2ZNF274_21170338_ChIP-Seq_K562_Hela3.79193451
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.55895810
4VDR_22108803_ChIP-Seq_LS180_Human3.31634787
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.05687888
6* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.91843925
7P63_26484246_Chip-Seq_KERATINOCYTES_Human2.87439387
8ZNF263_19887448_ChIP-Seq_K562_Human2.81039585
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.68611874
10* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50188441
11IGF1R_20145208_ChIP-Seq_DFB_Human2.45362782
12SOX9_24532713_ChIP-Seq_HFSC_Mouse2.37424855
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.35737050
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.30547524
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.27529896
16GBX2_23144817_ChIP-Seq_PC3_Human2.20537318
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09136433
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.07118273
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.07118273
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00409771
21TP63_17297297_ChIP-ChIP_HaCaT_Human17.2463071
22* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99844850
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.97253841
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95933427
25* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89722954
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78188799
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.76159690
28FOXO3_23340844_ChIP-Seq_DLD1_Human1.69967873
29FUS_26573619_Chip-Seq_HEK293_Human1.65626704
30* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64650455
31* P300_19829295_ChIP-Seq_ESCs_Human1.62075916
32* AR_25329375_ChIP-Seq_VCAP_Human1.57219357
33SOX2_20726797_ChIP-Seq_SW620_Human1.55594082
34ATF3_27146783_Chip-Seq_COLON_Human1.55502393
35ER_23166858_ChIP-Seq_MCF-7_Human1.55213648
36TAF15_26573619_Chip-Seq_HEK293_Human1.52467162
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.49577832
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49577832
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48959897
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47477310
41* PIAS1_25552417_ChIP-Seq_VCAP_Human1.45381026
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44625394
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.44221901
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43747326
45* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40514226
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39037316
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.37194734
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36449298
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.35610146
50EZH2_22144423_ChIP-Seq_EOC_Human1.35561758
51CBP_20019798_ChIP-Seq_JUKART_Human1.35447125
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35447125
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35019751
54* NCOR_22424771_ChIP-Seq_293T_Human1.34038703
55RXR_22108803_ChIP-Seq_LS180_Human1.33881776
56SMAD4_21799915_ChIP-Seq_A2780_Human1.33730120
57* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31952311
58STAT3_23295773_ChIP-Seq_U87_Human1.31683705
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30777970
60EWS_26573619_Chip-Seq_HEK293_Human1.30177804
61RBPJ_21746931_ChIP-Seq_IB4_Human1.29980195
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29887231
63HOXB7_26014856_ChIP-Seq_BT474_Human1.29244188
64* TP63_23658742_ChIP-Seq_EP156T_Human1.28431512
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.27521117
66NANOG_19829295_ChIP-Seq_ESCs_Human1.26642366
67SOX2_19829295_ChIP-Seq_ESCs_Human1.26642366
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.26219687
69* TP63_22573176_ChIP-Seq_HFKS_Human1.25778938
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25587789
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24800984
72ETV1_20927104_ChIP-Seq_GIST48_Human1.24427501
73* KLF5_25053715_ChIP-Seq_YYC3_Human1.24312413
74* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24259273
75TCF4_23295773_ChIP-Seq_U87_Human1.23370278
76AR_20517297_ChIP-Seq_VCAP_Human1.23000733
77RACK7_27058665_Chip-Seq_MCF-7_Human1.22565889
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22276094
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.21984940
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21145175
81* SMAD3_21741376_ChIP-Seq_EPCs_Human1.20844931
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20355789
83AR_21572438_ChIP-Seq_LNCaP_Human1.20276659
84EGR1_19032775_ChIP-ChIP_M12_Human1.20114830
85GATA4_25053715_ChIP-Seq_YYC3_Human1.20063761
86CLOCK_20551151_ChIP-Seq_293T_Human1.19010402
87* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18628147
88* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18619013
89GATA3_24758297_ChIP-Seq_MCF-7_Human1.18391751
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18337134
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17848438
92CJUN_26792858_Chip-Seq_BT549_Human1.17297569
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17222660
94PHF8_20622853_ChIP-Seq_HELA_Human1.17014816
95* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16877365
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15982008
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14600324
98CDX2_22108803_ChIP-Seq_LS180_Human1.13980690
99PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.13402773
100NOTCH1_21737748_ChIP-Seq_TLL_Human1.11952275
101GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.11867581
102CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11863473
103HNFA_21074721_ChIP-Seq_CACO-2_Human1.11731001
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11416862
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11071568
106MYC_18940864_ChIP-ChIP_HL60_Human1.10768788
107* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10475562
108CBX2_22325352_ChIP-Seq_293T-Rex_Human1.10186624
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09494040
110* SMAD4_21741376_ChIP-Seq_EPCs_Human1.07811119
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07175380
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06695540
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.06422544
114FOXH1_21741376_ChIP-Seq_EPCs_Human1.05694836
115NFYB_21822215_ChIP-Seq_K562_Human1.05519655
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.05284669
117* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04271511
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.02774917
119TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01773103
120TBL1_22424771_ChIP-Seq_293T_Human1.00922677
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99494164
122GATA6_25053715_ChIP-Seq_YYC3_Human0.99208705
123TP53_18474530_ChIP-ChIP_U2OS_Human0.96249920
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96109998
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.95712934
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95404355
127GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94818083
128UBF1/2_26484160_Chip-Seq_HMECs_Human0.94043713
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.93442606
130RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91349858
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87752402
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86035924
133* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.85866006
134CTCF_20526341_ChIP-Seq_ESCs_Human0.85730277
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85658658
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85502356
137CEBPB_22108803_ChIP-Seq_LS180_Human0.85329783
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.84884233
139GATA6_21074721_ChIP-Seq_CACO-2_Human0.83919093
140JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80143964
141P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.80031658
142* ERG_20517297_ChIP-Seq_VCAP_Human0.80022461
143JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79300312
144AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76298555
145SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75067405
146UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.74263558
147SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71120351
148BCOR_27268052_Chip-Seq_Bcells_Human0.70892310
149PPARA_22158963_ChIP-Seq_LIVER_Mouse0.70684528
150AHR_22903824_ChIP-Seq_MCF-7_Human0.70280118
151CDX2_20551321_ChIP-Seq_CACO-2_Human0.69277845
152NANOG_20526341_ChIP-Seq_ESCs_Human0.69269380
153FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.68571128
154CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67526092
155HTT_18923047_ChIP-ChIP_STHdh_Human0.67482423
156CTCF_27219007_Chip-Seq_Bcells_Human0.67023493
157FOXM1_26456572_ChIP-Seq_MCF-7_Human0.66878568
158E2F1_20622854_ChIP-Seq_HELA_Human0.66706363
159BCAT_22108803_ChIP-Seq_LS180_Human0.66679584
160ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.65680632
161DNAJC2_21179169_ChIP-ChIP_NT2_Human0.65503418
162HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.64559662
163SA1_27219007_Chip-Seq_ERYTHROID_Human0.64136516
164EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.62036154
165TCF4_22108803_ChIP-Seq_LS180_Human0.61804244
166LXR_22292898_ChIP-Seq_THP-1_Human0.60523109
167CSB_26484114_Chip-Seq_FIBROBLAST_Human0.59550498
168BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.59043481
169RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58901045
170P300_27058665_Chip-Seq_ZR-75-30cells_Human0.58795750
171JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.58185606
172FOXA1_21572438_ChIP-Seq_LNCaP_Human0.58083758
173RXR_22158963_ChIP-Seq_LIVER_Mouse0.56984990
174FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56892631
175GATA2_21666600_ChIP-Seq_HMVEC_Human0.56382180
176P53_21459846_ChIP-Seq_SAOS-2_Human0.56183163
177ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.55499622
178RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.54961758
179RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.54876227
180TBX20_22328084_ChIP-Seq_HEART_Mouse0.51971031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.89469786
2MP0000579_abnormal_nail_morphology5.38646312
3MP0004381_abnormal_hair_follicle4.95371471
4MP0005275_abnormal_skin_tensile4.52843514
5MP0000372_irregular_coat_pigmentation4.34536635
6MP0010234_abnormal_vibrissa_follicle4.28076843
7MP0005501_abnormal_skin_physiology4.18144365
8MP0005171_absent_coat_pigmentation3.50589481
9MP0000383_abnormal_hair_follicle3.41388970
10MP0000467_abnormal_esophagus_morphology3.35262076
11MP0003136_yellow_coat_color3.22730444
12MP0001216_abnormal_epidermal_layer3.12609625
13MP0003705_abnormal_hypodermis_morpholog3.05222983
14MP0003453_abnormal_keratinocyte_physiol3.04358994
15MP0010678_abnormal_skin_adnexa3.02544485
16MP0002060_abnormal_skin_morphology2.67184747
17MP0004043_abnormal_pH_regulation2.66797721
18MP0001881_abnormal_mammary_gland2.62619759
19MP0002254_reproductive_system_inflammat2.55223978
20MP0010771_integument_phenotype2.54153664
21MP0005408_hypopigmentation2.51305986
22MP0003941_abnormal_skin_development2.46313788
23MP0000569_abnormal_digit_pigmentation2.43213436
24MP0000377_abnormal_hair_follicle2.35998591
25MP0000762_abnormal_tongue_morphology2.33816397
26MP0002098_abnormal_vibrissa_morphology2.30813439
27MP0004947_skin_inflammation2.16787067
28MP0000647_abnormal_sebaceous_gland2.06112900
29MP0002837_dystrophic_cardiac_calcinosis1.95759198
30MP0004145_abnormal_muscle_electrophysio1.93351486
31MP0002095_abnormal_skin_pigmentation1.87309286
32MP0002877_abnormal_melanocyte_morpholog1.82182260
33MP0000427_abnormal_hair_cycle1.79861731
34MP0003566_abnormal_cell_adhesion1.76265898
35MP0008875_abnormal_xenobiotic_pharmacok1.68508740
36MP0005409_darkened_coat_color1.66888743
37MP0000367_abnormal_coat/_hair1.65236979
38MP0000371_diluted_coat_color1.58118957
39MP0009931_abnormal_skin_appearance1.49439053
40MP0005257_abnormal_intraocular_pressure1.41049390
41MP0004185_abnormal_adipocyte_glucose1.38172930
42MP0000627_abnormal_mammary_gland1.36794325
43MP0002234_abnormal_pharynx_morphology1.32992991
44MP0005551_abnormal_eye_electrophysiolog1.31610157
45MP0001191_abnormal_skin_condition1.29651670
46MP0005451_abnormal_body_composition1.25813509
47MP0008872_abnormal_physiological_respon1.25183439
48MP0005174_abnormal_tail_pigmentation1.23061558
49MP0001849_ear_inflammation1.19991643
50MP0004264_abnormal_extraembryonic_tissu1.19605941
51MP0004215_abnormal_myocardial_fiber1.18419583
52MP0001501_abnormal_sleep_pattern1.18323818
53MP0001485_abnormal_pinna_reflex1.18185392
54MP0005075_abnormal_melanosome_morpholog1.17947823
55MP0004147_increased_porphyrin_level1.17258997
56MP0001968_abnormal_touch/_nociception1.17162499
57MP0005023_abnormal_wound_healing1.17088241
58MP0004142_abnormal_muscle_tone1.15804742
59MP0006072_abnormal_retinal_apoptosis1.14716460
60MP0003195_calcinosis1.12586259
61MP0003880_abnormal_central_pattern1.08045734
62MP0003011_delayed_dark_adaptation1.05335822
63MP0005253_abnormal_eye_physiology1.03293467
64MP0004019_abnormal_vitamin_homeostasis1.03020052
65MP0002736_abnormal_nociception_after1.01053647
66MP0001243_abnormal_dermal_layer1.00555983
67MP0002638_abnormal_pupillary_reflex1.00464795
68MP0002075_abnormal_coat/hair_pigmentati1.00216961
69MP0001905_abnormal_dopamine_level0.98186411
70MP0009046_muscle_twitch0.97128928
71MP0009745_abnormal_behavioral_response0.94972683
72MP0002938_white_spotting0.94941091
73MP0001851_eye_inflammation0.93080481
74MP0005377_hearing/vestibular/ear_phenot0.92964884
75MP0003878_abnormal_ear_physiology0.92964884
76MP0003718_maternal_effect0.92352111
77MP0001186_pigmentation_phenotype0.92058625
78MP0010352_gastrointestinal_tract_polyps0.89954984
79MP0004885_abnormal_endolymph0.89367357
80MP0003950_abnormal_plasma_membrane0.88825646
81MP0002277_abnormal_respiratory_mucosa0.87854747
82MP0001324_abnormal_eye_pigmentation0.83569771
83MP0005248_abnormal_Harderian_gland0.80706972
84MP0000749_muscle_degeneration0.80124115
85MP0001986_abnormal_taste_sensitivity0.78855689
86MP0002160_abnormal_reproductive_system0.78325797
87MP0009053_abnormal_anal_canal0.76596189
88MP0005389_reproductive_system_phenotype0.76077761
89MP0002102_abnormal_ear_morphology0.75056956
90MP0001919_abnormal_reproductive_system0.74542988
91MP0009780_abnormal_chondrocyte_physiolo0.73248376
92MP0003638_abnormal_response/metabolism_0.72054622
93MP0000631_abnormal_neuroendocrine_gland0.71870307
94MP0005670_abnormal_white_adipose0.71868622
95MP0004924_abnormal_behavior0.71861532
96MP0005386_behavior/neurological_phenoty0.71861532
97MP0003045_fibrosis0.71785857
98MP0003191_abnormal_cellular_cholesterol0.71303100
99MP0002909_abnormal_adrenal_gland0.67675832
100MP0001984_abnormal_olfaction0.67582248
101MP0002653_abnormal_ependyma_morphology0.66056410
102MP0000465_gastrointestinal_hemorrhage0.65551007
103MP0001502_abnormal_circadian_rhythm0.64358000
104MP0002272_abnormal_nervous_system0.62919081
105MP0000566_synostosis0.61001676
106MP0005646_abnormal_pituitary_gland0.60644556
107MP0003890_abnormal_embryonic-extraembry0.60372980
108MP0002876_abnormal_thyroid_physiology0.59714862
109MP0001765_abnormal_ion_homeostasis0.58593138
110MP0008789_abnormal_olfactory_epithelium0.58538318
111MP0002733_abnormal_thermal_nociception0.58193043
112MP0002138_abnormal_hepatobiliary_system0.57435021
113MP0002332_abnormal_exercise_endurance0.57280207
114MP0001340_abnormal_eyelid_morphology0.56363802
115MP0003300_gastrointestinal_ulcer0.55808246
116MP0001529_abnormal_vocalization0.54437798
117MP0004133_heterotaxia0.54188392
118MP0003137_abnormal_impulse_conducting0.53208399
119MP0000026_abnormal_inner_ear0.51498696
120MP0006054_spinal_hemorrhage0.50816490
121MP0001666_abnormal_nutrient_absorption0.50532019
122MP0002177_abnormal_outer_ear0.50512509
123MP0003303_peritoneal_inflammation0.50417148
124MP0002090_abnormal_vision0.48826091
125MP0001346_abnormal_lacrimal_gland0.47318435
126MP0005666_abnormal_adipose_tissue0.47054300
127MP0002282_abnormal_trachea_morphology0.42915185
128MP0002009_preneoplasia0.41150447
129MP0001784_abnormal_fluid_regulation0.40095352
130MP0005083_abnormal_biliary_tract0.38693105
131MP0004782_abnormal_surfactant_physiolog0.38586882
132MP0003755_abnormal_palate_morphology0.36425303
133MP0004272_abnormal_basement_membrane0.35316839
134MP0005197_abnormal_uvea_morphology0.33299270
135MP0005193_abnormal_anterior_eye0.32368561
136MP0009384_cardiac_valve_regurgitation0.31210586
137MP0000015_abnormal_ear_pigmentation0.30990269
138MP0000733_abnormal_muscle_development0.30608184
139MP0006138_congestive_heart_failure0.29672270
140MP0000470_abnormal_stomach_morphology0.29096246
141MP0003646_muscle_fatigue0.28831204
142MP0009840_abnormal_foam_cell0.28208770
143MP0002111_abnormal_tail_morphology0.27718168
144MP0003315_abnormal_perineum_morphology0.27661970
145MP0001873_stomach_inflammation0.25621386
146MP0008770_decreased_survivor_rate0.24259525
147MP0005395_other_phenotype0.23886867
148MP0000538_abnormal_urinary_bladder0.23474631
149MP0005375_adipose_tissue_phenotype0.23247159
150MP0000678_abnormal_parathyroid_gland0.23212668
151MP0000750_abnormal_muscle_regeneration0.22230409
152MP0003938_abnormal_ear_development0.22124242
153MP0001188_hyperpigmentation0.21927659
154MP0008438_abnormal_cutaneous_collagen0.20783996

Predicted human phenotypes

RankGene SetZ-score
1Thick nail (HP:0001805)7.73928759
2Palmoplantar hyperkeratosis (HP:0000972)7.56928116
3Plantar hyperkeratosis (HP:0007556)7.53015928
4Palmar hyperkeratosis (HP:0010765)7.12939251
5Hypotrichosis (HP:0001006)6.43952988
6Oral leukoplakia (HP:0002745)6.43888140
7Conjunctival hamartoma (HP:0100780)6.21770772
8Alopecia of scalp (HP:0002293)5.96586296
9Onycholysis (HP:0001806)5.88937546
10Increased IgE level (HP:0003212)5.64342188
11Fragile nails (HP:0001808)5.57009576
12Milia (HP:0001056)5.50342831
13Woolly hair (HP:0002224)5.45777528
14Erythroderma (HP:0001019)5.02832675
15Right ventricular cardiomyopathy (HP:0011663)5.00397573
16Pili torti (HP:0003777)4.75509737
17Abnormal blistering of the skin (HP:0008066)4.72862049
18Erythema (HP:0010783)4.50911872
19Congenital ichthyosiform erythroderma (HP:0007431)4.44897436
20Follicular hyperkeratosis (HP:0007502)4.27499615
21Nail dystrophy (HP:0008404)4.26873752
22Parakeratosis (HP:0001036)3.86387299
23Hamartoma of the eye (HP:0010568)3.84481092
24Duplicated collecting system (HP:0000081)3.50309583
25Ectropion (HP:0000656)3.40900242
26Sparse eyelashes (HP:0000653)3.35724366
27Palmoplantar keratoderma (HP:0000982)3.34873348
28Lip pit (HP:0100267)3.34603242
29Aplasia/Hypoplasia of the macula (HP:0008059)3.23383159
30Atrophic scars (HP:0001075)3.22479489
31Abnormality of the renal collecting system (HP:0004742)3.18595135
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.15024212
33Aplasia/Hypoplasia affecting the retina (HP:0008061)3.02578174
34Natal tooth (HP:0000695)3.01633649
35Hypohidrosis (HP:0000966)2.97162860
36Ridged nail (HP:0001807)2.93063196
37Pancreatic cysts (HP:0001737)2.92132465
38Laryngomalacia (HP:0001601)2.90846054
39Corneal erosion (HP:0200020)2.87564093
40Abnormal hair laboratory examination (HP:0003328)2.85072804
41Aplasia/Hypoplasia of the fovea (HP:0008060)2.81091693
42Hypoplasia of the fovea (HP:0007750)2.81091693
43Type II lissencephaly (HP:0007260)2.69473139
44Blue irides (HP:0000635)2.68789012
45Abnormality of the neuromuscular junction (HP:0003398)2.60804824
46Fatigable weakness (HP:0003473)2.60804824
47Advanced eruption of teeth (HP:0006288)2.58362318
48Corneal dystrophy (HP:0001131)2.58094389
49Hypoplastic labia majora (HP:0000059)2.57512520
50Gangrene (HP:0100758)2.53949440
51Fair hair (HP:0002286)2.48352741
52Ocular albinism (HP:0001107)2.42620674
53Hyperventilation (HP:0002883)2.42467783
54Absent hair (HP:0002298)2.42166894
55Large for gestational age (HP:0001520)2.41561966
56White forelock (HP:0002211)2.41184596
57Anonychia (HP:0001798)2.38129607
58Abnormality of the labia majora (HP:0012881)2.35686029
59Curly hair (HP:0002212)2.31962184
60Ventricular tachycardia (HP:0004756)2.28262597
61Ventricular fibrillation (HP:0001663)2.26609708
62Abnormality of secondary sexual hair (HP:0009888)2.23916121
63Abnormality of the axillary hair (HP:0100134)2.23916121
64True hermaphroditism (HP:0010459)2.23025116
65Congenital stationary night blindness (HP:0007642)2.22597409
66Hyperhidrosis (HP:0000975)2.21549619
67Abnormality of the renal cortex (HP:0011035)2.20728025
68Nephronophthisis (HP:0000090)2.20080816
69Conical tooth (HP:0000698)2.19026293
70Abnormality of midbrain morphology (HP:0002418)2.17313352
71Molar tooth sign on MRI (HP:0002419)2.17313352
72Amelogenesis imperfecta (HP:0000705)2.16706705
73Pancreatic fibrosis (HP:0100732)2.16168693
74Hypoplasia of the iris (HP:0007676)2.14275780
75Abnormality of the fovea (HP:0000493)2.13033306
76Brittle hair (HP:0002299)2.11893157
77Pruritus (HP:0000989)2.11545200
78Patchy hypopigmentation of hair (HP:0011365)2.11061164
79Iris hypopigmentation (HP:0007730)2.10574261
80Abnormality of the renal medulla (HP:0100957)2.08390281
81Congenital sensorineural hearing impairment (HP:0008527)2.07252879
82Tubular atrophy (HP:0000092)2.05079668
83Verrucae (HP:0200043)2.04872473
84Papilloma (HP:0012740)2.04872473
85Slow-growing hair (HP:0002217)2.04481643
86Abnormality of hair growth rate (HP:0011363)2.04481643
87Medial flaring of the eyebrow (HP:0010747)2.00930309
88Recurrent corneal erosions (HP:0000495)2.00583384
89Subacute progressive viral hepatitis (HP:0006572)2.00258866
90Abnormality of nail color (HP:0100643)11.1510799
91Pendular nystagmus (HP:0012043)1.99532756
92Cerebellar dysplasia (HP:0007033)1.98693486
93Abnormality of placental membranes (HP:0011409)1.97772350
94Amniotic constriction ring (HP:0009775)1.97772350
95Aplasia cutis congenita (HP:0001057)1.97025847
96Generalized hypopigmentation of hair (HP:0011358)1.94152235
97Blepharitis (HP:0000498)1.93598882
98Hypoplasia of dental enamel (HP:0006297)1.93115309
99Myopathic facies (HP:0002058)1.89548931
100Inability to walk (HP:0002540)1.89137571
101Aplasia/hypoplasia of the uterus (HP:0008684)1.88702663
102Stomach cancer (HP:0012126)1.88640218
103Carious teeth (HP:0000670)1.86531976
104Widely spaced teeth (HP:0000687)1.84173213
105Increased connective tissue (HP:0009025)1.83598175
106Labial hypoplasia (HP:0000066)1.82723541
107Hyperkalemia (HP:0002153)1.79149121
108Sparse scalp hair (HP:0002209)1.77158042
109Abnormality of the salivary glands (HP:0010286)1.75477576
110Congenital, generalized hypertrichosis (HP:0004540)1.75172160
111Acanthosis nigricans (HP:0000956)1.74724166
112Progressive inability to walk (HP:0002505)1.74574461
113Abnormality of the fingernails (HP:0001231)1.74234685
114Lissencephaly (HP:0001339)1.73651713
115Hypothermia (HP:0002045)1.72866494
116Skin ulcer (HP:0200042)1.70235192
117Hypoplasia of the uterus (HP:0000013)1.69830099
118Melanocytic nevus (HP:0000995)1.69755240
1193-Methylglutaconic aciduria (HP:0003535)1.69384579
120Oligodontia (HP:0000677)1.68744788
121Decreased circulating renin level (HP:0003351)1.68661160
122Pterygium (HP:0001059)1.67717631
123Non-midline cleft lip (HP:0100335)1.63829554
124Abnormality of the pons (HP:0007361)1.63657813
125Hyporeflexia of lower limbs (HP:0002600)1.62354796
126Depressed nasal tip (HP:0000437)1.62218004
127Abnormality of vision evoked potentials (HP:0000649)1.61611390
128Broad-based gait (HP:0002136)1.58054144
129Fragile skin (HP:0001030)1.57949177
130Clumsiness (HP:0002312)1.57180294
131Hypopigmentation of the fundus (HP:0007894)1.56810852
132Hypoplastic female external genitalia (HP:0012815)1.56246383
133Lack of skin elasticity (HP:0100679)1.55905288
134Cystic liver disease (HP:0006706)1.54970138
135Dry hair (HP:0011359)1.54763407
136Hypergammaglobulinemia (HP:0010702)1.54110498
137Abnormal hemoglobin (HP:0011902)1.53406675
138Attenuation of retinal blood vessels (HP:0007843)1.53041855
139Severe Myopia (HP:0011003)1.52556579
140Popliteal pterygium (HP:0009756)1.52426251
141Generalized hypopigmentation (HP:0007513)1.52145415
142Trismus (HP:0000211)1.48883242
143Scapular winging (HP:0003691)1.46316751
144Hamartoma (HP:0010566)1.44225170
145Thin bony cortex (HP:0002753)1.42849510
146Dehydration (HP:0001944)1.40857775
147Autoamputation (HP:0001218)1.40510819
148Furrowed tongue (HP:0000221)1.39407994
149Absent eyelashes (HP:0000561)1.39013932
150Hypoparathyroidism (HP:0000829)1.37844217
151Pustule (HP:0200039)1.37022732
152Distal lower limb muscle weakness (HP:0009053)1.34798427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MET4.02235255
2MAPKAPK33.10304596
3PKN22.96357447
4ADRBK22.93361939
5TRIB32.81432151
6ZAK2.73852264
7TGFBR12.73203150
8INSRR2.65677688
9FER2.40466652
10GRK12.26911039
11EEF2K2.25514556
12BMX2.23454345
13PHKG12.13326875
14PHKG22.13326875
15EPHA32.08729531
16BMPR1B2.07231879
17LATS12.07210424
18MAP3K32.06304108
19MST1R10.1471991
20CASK1.94653434
21ERN11.91623615
22NUAK11.88235189
23MAP4K21.75249476
24TLK11.73786494
25ACVR1B1.71633590
26TNIK1.71207788
27TTN1.69677115
28WNK31.67259916
29CAMK1D1.62038362
30MUSK1.61249946
31CAMKK21.60889943
32MST41.60285997
33MARK31.58389201
34PINK11.56831035
35TRPM71.55099683
36PNCK1.53345792
37EPHA21.53194744
38WEE11.51809093
39MAPK131.51558441
40PDK31.46113808
41PDK41.46113808
42RPS6KB21.44798053
43WNK41.44028399
44MARK11.42748336
45EIF2AK31.42333408
46PTK61.37451448
47MAPK151.36932885
48DDR21.31070557
49LRRK21.30929346
50MAP3K21.27141000
51OXSR11.25625107
52ADRBK11.21900265
53PIK3CG1.19384173
54IKBKB1.18700576
55MAP3K11.15699349
56BRSK21.15552103
57MAP3K41.10329489
58IRAK11.10057377
59PRKCE1.06214848
60NME21.04968779
61MAP3K111.03634386
62MAPKAPK51.00431017
63PDK20.99370026
64NME10.98456800
65TGFBR20.98258489
66MKNK20.95485231
67MAP3K90.93389387
68STK390.91758813
69PAK30.91030728
70MAP2K60.89946210
71DYRK20.89865497
72DAPK20.88375118
73LATS20.88218288
74PLK20.87451143
75BLK0.83692046
76TAOK30.83324162
77NLK0.82740327
78SIK10.82085938
79TAOK10.82040126
80RIPK10.82020927
81TIE10.81964653
82CAMK1G0.80881427
83FRK0.79215899
84NEK10.78086949
85TYK20.77255763
86MAP3K60.76079356
87NEK20.71046152
88RPS6KA40.71036021
89CDK60.70878660
90VRK10.69466343
91MAP3K70.68647868
92EIF2AK10.68200800
93CHUK0.66599019
94EPHB20.66352598
95PRKAA20.65765374
96MAP2K70.64507926
97GSK3A0.64129652
98BUB10.63843611
99EPHB10.62931504
100PRKCG0.61883413
101FGFR10.60144441
102FGFR40.60091802
103PIM20.57899535
104PTK2B0.57471274
105BCR0.57298364
106KSR20.56920600
107CCNB10.54064531
108TRIM280.53607679
109PDGFRB0.52540663
110STK38L0.51850051
111MAP3K120.50141634
112PLK40.48785048
113MAPKAPK20.48188252
114TXK0.46805696
115STK240.45685249
116PKN10.43422339
117FGR0.43228931
118TBK10.42297058
119TYRO30.41566720
120SGK4940.41032813
121SGK2230.41032813
122FLT30.40190788
123RET0.39777806
124STK30.38744351
125CDK80.38474974
126STK100.38213526
127MAP2K30.38204116
128ERBB30.37786353
129CAMK2A0.37771820
130TSSK60.37529417
131PTK20.37255823
132RPS6KA50.37184101
133PBK0.37144315
134JAK20.36940273
135ILK0.36538379
136GRK50.36471880
137PLK30.36437533
138JAK10.36291852
139PRKACA0.35575598
140FGFR30.35087258
141MAP2K40.34957982
142MAPK120.34918901
143MAP2K10.34009282
144ABL10.33749077
145EIF2AK20.33511789
146IGF1R0.33162263
147BCKDK0.32611178
148IKBKE0.32307404
149DMPK0.31281767
150RPS6KA10.31020854
151PRKD10.30771329
152ZAP700.29862922
153PDGFRA0.28244089
154NTRK20.25757192
155GRK70.23403872
156ALK0.23379450
157PRKCI0.22063697
158CDK190.21845775
159OBSCN0.21807198
160MAPK110.21702216
161PRKAA10.20892899
162MAP2K20.20589366
163STK380.19571429
164TESK10.17990144
165PIK3CA0.17869965
166MAP3K80.16666167
167CSNK1A10.16160876
168DYRK1B0.15735777

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002326.76367325
2Fatty acid biosynthesis_Homo sapiens_hsa000616.43352881
3Tyrosine metabolism_Homo sapiens_hsa003503.21879536
4Phototransduction_Homo sapiens_hsa047442.95552570
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.91388039
6Nitrogen metabolism_Homo sapiens_hsa009102.68653065
7Fatty acid elongation_Homo sapiens_hsa000622.66157574
8Linoleic acid metabolism_Homo sapiens_hsa005912.64599996
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.31062834
10Oxidative phosphorylation_Homo sapiens_hsa001902.27489880
11Galactose metabolism_Homo sapiens_hsa000522.17608871
12Fat digestion and absorption_Homo sapiens_hsa049752.12049321
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11835166
14Butanoate metabolism_Homo sapiens_hsa006502.07265800
15Sphingolipid metabolism_Homo sapiens_hsa006001.94536728
16Tryptophan metabolism_Homo sapiens_hsa003801.85305812
17Steroid biosynthesis_Homo sapiens_hsa001001.84727933
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81617591
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.70540147
20Protein export_Homo sapiens_hsa030601.69968609
21Arachidonic acid metabolism_Homo sapiens_hsa005901.69522289
22Parkinsons disease_Homo sapiens_hsa050121.68442523
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.59393644
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53582499
25Ether lipid metabolism_Homo sapiens_hsa005651.52120167
26Ribosome_Homo sapiens_hsa030101.49874960
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49172366
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44879536
29Selenocompound metabolism_Homo sapiens_hsa004501.44065447
30Fatty acid metabolism_Homo sapiens_hsa012121.42547848
31Phenylalanine metabolism_Homo sapiens_hsa003601.41510110
32Circadian rhythm_Homo sapiens_hsa047101.38791652
33Melanogenesis_Homo sapiens_hsa049161.37227646
34Nicotine addiction_Homo sapiens_hsa050331.34058942
35Basal transcription factors_Homo sapiens_hsa030221.32973063
36Mineral absorption_Homo sapiens_hsa049781.30045918
37Prolactin signaling pathway_Homo sapiens_hsa049171.28565933
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.27956777
39Serotonergic synapse_Homo sapiens_hsa047261.25703120
40VEGF signaling pathway_Homo sapiens_hsa043701.23539348
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23277331
42Cardiac muscle contraction_Homo sapiens_hsa042601.22545236
43ABC transporters_Homo sapiens_hsa020101.22248745
44Chemical carcinogenesis_Homo sapiens_hsa052041.21654230
45Alzheimers disease_Homo sapiens_hsa050101.19310833
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19306840
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17139105
48Proteasome_Homo sapiens_hsa030501.11441266
49Tight junction_Homo sapiens_hsa045301.08569728
50Vitamin digestion and absorption_Homo sapiens_hsa049771.07918216
51Taste transduction_Homo sapiens_hsa047421.07771759
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07074799
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03519057
54PPAR signaling pathway_Homo sapiens_hsa033201.01458237
55ECM-receptor interaction_Homo sapiens_hsa045120.99876984
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98585763
57Pentose phosphate pathway_Homo sapiens_hsa000300.98471325
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95561855
59Propanoate metabolism_Homo sapiens_hsa006400.94647076
60Adherens junction_Homo sapiens_hsa045200.90118745
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88177978
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87704260
63Histidine metabolism_Homo sapiens_hsa003400.86899073
64Sulfur metabolism_Homo sapiens_hsa009200.83919756
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83408557
66Huntingtons disease_Homo sapiens_hsa050160.83002910
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82607625
68Glutamatergic synapse_Homo sapiens_hsa047240.81638043
69Olfactory transduction_Homo sapiens_hsa047400.81326796
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81154429
71Pyruvate metabolism_Homo sapiens_hsa006200.77820469
72Dorso-ventral axis formation_Homo sapiens_hsa043200.77698008
73Arginine and proline metabolism_Homo sapiens_hsa003300.76812120
74p53 signaling pathway_Homo sapiens_hsa041150.76604088
75Staphylococcus aureus infection_Homo sapiens_hsa051500.76399889
76RNA degradation_Homo sapiens_hsa030180.76032023
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74670789
78Proteoglycans in cancer_Homo sapiens_hsa052050.73352587
79Homologous recombination_Homo sapiens_hsa034400.71999856
80GnRH signaling pathway_Homo sapiens_hsa049120.71670927
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71562575
82Circadian entrainment_Homo sapiens_hsa047130.70772291
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69684451
84Amoebiasis_Homo sapiens_hsa051460.68652575
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.66898543
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.66878195
87Fanconi anemia pathway_Homo sapiens_hsa034600.66419919
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66047664
89Peroxisome_Homo sapiens_hsa041460.65697386
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65416801
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.64866031
92Calcium signaling pathway_Homo sapiens_hsa040200.64767916
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63197968
94Metabolic pathways_Homo sapiens_hsa011000.61758588
95Hepatitis C_Homo sapiens_hsa051600.58997920
96Collecting duct acid secretion_Homo sapiens_hsa049660.58984799
97Carbon metabolism_Homo sapiens_hsa012000.57973183
98Gastric acid secretion_Homo sapiens_hsa049710.57507309
99Bladder cancer_Homo sapiens_hsa052190.56886310
100Renal cell carcinoma_Homo sapiens_hsa052110.56251576
101Retinol metabolism_Homo sapiens_hsa008300.55358686
102Morphine addiction_Homo sapiens_hsa050320.55024757
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54683527
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.54624288
105Salivary secretion_Homo sapiens_hsa049700.54230882
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.53804462
107Toxoplasmosis_Homo sapiens_hsa051450.52851989
108beta-Alanine metabolism_Homo sapiens_hsa004100.52345350
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51301888
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.51019297
111Folate biosynthesis_Homo sapiens_hsa007900.50362928
112Basal cell carcinoma_Homo sapiens_hsa052170.49652593
113RNA polymerase_Homo sapiens_hsa030200.49408686
114Small cell lung cancer_Homo sapiens_hsa052220.49225923
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46920519
116GABAergic synapse_Homo sapiens_hsa047270.46900784
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46134080
118Arginine biosynthesis_Homo sapiens_hsa002200.46042843
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45910415
120Insulin resistance_Homo sapiens_hsa049310.44283999
121Starch and sucrose metabolism_Homo sapiens_hsa005000.44212060
122Regulation of autophagy_Homo sapiens_hsa041400.44068634
123Pancreatic secretion_Homo sapiens_hsa049720.43366097
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43218371
125Oxytocin signaling pathway_Homo sapiens_hsa049210.42613199
126Glycerolipid metabolism_Homo sapiens_hsa005610.41675200
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41494981
128Vibrio cholerae infection_Homo sapiens_hsa051100.40288122
129Hippo signaling pathway_Homo sapiens_hsa043900.40266093
130Pertussis_Homo sapiens_hsa051330.39875514
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38323899
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38043151
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37159683
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36960641
135MicroRNAs in cancer_Homo sapiens_hsa052060.36662600
136Endocytosis_Homo sapiens_hsa041440.36661644
137Ovarian steroidogenesis_Homo sapiens_hsa049130.36633898
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35455580
139Melanoma_Homo sapiens_hsa052180.35313877
140Ras signaling pathway_Homo sapiens_hsa040140.35113453
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.34883399
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34872759
143One carbon pool by folate_Homo sapiens_hsa006700.34366382
144Hedgehog signaling pathway_Homo sapiens_hsa043400.34290949
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.34222682
146Estrogen signaling pathway_Homo sapiens_hsa049150.33326305
147Biosynthesis of amino acids_Homo sapiens_hsa012300.32986375
148Long-term depression_Homo sapiens_hsa047300.32788948
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32276566
150Lysosome_Homo sapiens_hsa041420.31521857
151Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30533564
152Fructose and mannose metabolism_Homo sapiens_hsa000510.30060425
153Dopaminergic synapse_Homo sapiens_hsa047280.29980924
154Acute myeloid leukemia_Homo sapiens_hsa052210.29370016
155Focal adhesion_Homo sapiens_hsa045100.29352381
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29280923
157Axon guidance_Homo sapiens_hsa043600.29200056
158Malaria_Homo sapiens_hsa051440.28964357
159HIF-1 signaling pathway_Homo sapiens_hsa040660.28284509
160AMPK signaling pathway_Homo sapiens_hsa041520.27467576
161Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26710127
162Fatty acid degradation_Homo sapiens_hsa000710.26411028
163Platelet activation_Homo sapiens_hsa046110.24954318
164Phagosome_Homo sapiens_hsa041450.23808079
165Glioma_Homo sapiens_hsa052140.23690353

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