GSDMD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interferon-beta biosynthetic process (GO:0045357)5.33612717
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.12331256
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.12331256
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.01212781
5negative regulation of cell killing (GO:0031342)5.01212781
6positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.00205374
7antigen processing and presentation of endogenous antigen (GO:0019883)4.84437962
8positive regulation of interferon-alpha production (GO:0032727)4.42964479
9cellular response to virus (GO:0098586)4.40922143
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.23515937
11regulation of interferon-alpha production (GO:0032647)4.15908109
12activated T cell proliferation (GO:0050798)4.13468437
13detection of bacterium (GO:0016045)4.03198726
14response to type I interferon (GO:0034340)3.81620059
15cellular response to type I interferon (GO:0071357)3.72387335
16type I interferon signaling pathway (GO:0060337)3.72387335
17regulation of integrin activation (GO:0033623)3.68633034
18positive regulation of interferon-beta production (GO:0032728)3.58624390
19positive regulation of gamma-delta T cell activation (GO:0046645)3.55276171
20positive regulation of glycoprotein biosynthetic process (GO:0010560)3.49396139
21diacylglycerol metabolic process (GO:0046339)3.47151226
22cellular response to zinc ion (GO:0071294)3.46464656
23proline biosynthetic process (GO:0006561)3.38871392
24regulation of T cell tolerance induction (GO:0002664)3.37077334
25immunoglobulin mediated immune response (GO:0016064)3.36191041
26regulation of regulatory T cell differentiation (GO:0045589)3.32882624
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.31123833
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.30719944
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.29461606
30interferon-gamma-mediated signaling pathway (GO:0060333)3.27210839
31detection of external biotic stimulus (GO:0098581)3.24534885
32intestinal cholesterol absorption (GO:0030299)3.22982890
33regulation of B cell receptor signaling pathway (GO:0050855)3.22808585
34positive regulation of glycoprotein metabolic process (GO:1903020)3.20876080
35positive regulation of protein homooligomerization (GO:0032464)3.20549966
36regulation of protein glycosylation (GO:0060049)3.19951280
37positive thymic T cell selection (GO:0045059)3.17593938
38embryonic process involved in female pregnancy (GO:0060136)3.17429276
39positive regulation of T cell mediated cytotoxicity (GO:0001916)3.15572499
40cellular extravasation (GO:0045123)3.15095480
41NIK/NF-kappaB signaling (GO:0038061)3.12828467
42regulation of tolerance induction (GO:0002643)3.11067732
43negative regulation of leukocyte mediated immunity (GO:0002704)3.10491726
44regulation of antigen processing and presentation (GO:0002577)3.08446303
45regulation of T cell mediated cytotoxicity (GO:0001914)3.07305462
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.03513553
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.03513553
48modulation by symbiont of host immune response (GO:0052553)3.03513553
49positive regulation by symbiont of host defense response (GO:0052509)3.03513553
50modulation by symbiont of host defense response (GO:0052031)3.03513553
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.03513553
52neutrophil activation involved in immune response (GO:0002283)3.03458153
53regulation of type I interferon-mediated signaling pathway (GO:0060338)3.03323521
54granulocyte activation (GO:0036230)3.02999071
55response to interferon-beta (GO:0035456)2.99921935
56response to interleukin-15 (GO:0070672)2.96663805
57positive regulation of B cell differentiation (GO:0045579)2.95532227
58B cell receptor signaling pathway (GO:0050853)2.95045496
59leukocyte migration involved in inflammatory response (GO:0002523)2.91517588
60regulation of interferon-beta production (GO:0032648)2.91193129
61negative thymic T cell selection (GO:0045060)2.90416164
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90268725
63regulation of interleukin-12 biosynthetic process (GO:0045075)2.90211828
64detection of biotic stimulus (GO:0009595)2.90018734
65negative regulation of cytokine production involved in immune response (GO:0002719)2.89823081
66antigen processing and presentation via MHC class Ib (GO:0002475)2.89296516
67negative regulation of phagocytosis (GO:0050765)2.86943062
68negative T cell selection (GO:0043383)2.83376138
69germinal center formation (GO:0002467)2.81581263
70T cell selection (GO:0045058)2.81102405
71negative regulation of innate immune response (GO:0045824)2.80745700
72lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80351983
73regulation of B cell differentiation (GO:0045577)2.78713280
74sulfur amino acid catabolic process (GO:0000098)2.78582658
75Arp2/3 complex-mediated actin nucleation (GO:0034314)2.78166872
76phospholipid efflux (GO:0033700)2.77770854
77tolerance induction (GO:0002507)2.76044485
78regulation of gamma-delta T cell differentiation (GO:0045586)2.75777114
79intestinal absorption (GO:0050892)2.75448487
80negative regulation of interleukin-12 production (GO:0032695)2.75208042
81heterotypic cell-cell adhesion (GO:0034113)2.71751259
82regulation of gamma-delta T cell activation (GO:0046643)2.71060852
83dendritic cell chemotaxis (GO:0002407)2.70998834
84regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.68929795
85regulation of natural killer cell mediated immunity (GO:0002715)2.68929795
86mannose metabolic process (GO:0006013)2.67189446
87neutrophil chemotaxis (GO:0030593)2.66807925
88thymic T cell selection (GO:0045061)2.65563640
89macrophage activation involved in immune response (GO:0002281)2.65418270
90positive regulation of Cdc42 GTPase activity (GO:0043089)2.64917850
91positive regulation of antigen processing and presentation (GO:0002579)2.64361988
92myeloid cell activation involved in immune response (GO:0002275)2.63513660
93B cell mediated immunity (GO:0019724)2.63448630
94respiratory burst (GO:0045730)2.63219480
95response to peptidoglycan (GO:0032494)2.62908127
96plasma lipoprotein particle assembly (GO:0034377)2.62897850
97negative regulation of erythrocyte differentiation (GO:0045647)2.62805217
98defense response to protozoan (GO:0042832)2.62600570
99regulation of T-helper 1 cell differentiation (GO:0045625)2.61477374
100negative regulation of type I interferon production (GO:0032480)2.60811645
101regulation of mast cell degranulation (GO:0043304)2.60528454
102neutrophil migration (GO:1990266)2.60041127
103regulation of cellular extravasation (GO:0002691)2.59878956
104cellular response to interleukin-15 (GO:0071350)2.59763532
105negative regulation of interleukin-8 production (GO:0032717)2.58952033
106leukocyte aggregation (GO:0070486)2.58207878
107cellular response to interferon-beta (GO:0035458)2.57590974
108proline metabolic process (GO:0006560)2.57407887
109regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.57329705
110negative regulation of production of molecular mediator of immune response (GO:0002701)2.56741297
111negative regulation of viral genome replication (GO:0045071)2.56365246
112regulation of RIG-I signaling pathway (GO:0039535)2.56229061
113regulation of defense response to virus by host (GO:0050691)2.56120043
114positive regulation of tolerance induction (GO:0002645)2.55027637
115negative regulation of viral entry into host cell (GO:0046597)2.54738641
116triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.54573025
117hepatocyte apoptotic process (GO:0097284)2.53573606
118leukocyte cell-cell adhesion (GO:0007159)2.52249749
119positive regulation of protein oligomerization (GO:0032461)2.51839268
120mature B cell differentiation involved in immune response (GO:0002313)2.49306598
121T-helper 1 type immune response (GO:0042088)2.49082738
122programmed necrotic cell death (GO:0097300)2.48413402
123protein-lipid complex assembly (GO:0065005)2.48372856
124regulation of protein homooligomerization (GO:0032462)2.47457623
125T cell migration (GO:0072678)2.46629880
126positive regulation of lamellipodium assembly (GO:0010592)2.44170254
127positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.43460499
128response to protozoan (GO:0001562)2.42674085
129mature B cell differentiation (GO:0002335)2.42643279
130response to interferon-alpha (GO:0035455)2.42543108
131cellular response to interferon-gamma (GO:0071346)2.41559667
132nucleotide salvage (GO:0043173)2.39576381
133regulation of cholesterol homeostasis (GO:2000188)2.38605545
134very-low-density lipoprotein particle assembly (GO:0034379)2.36328189
135regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.35709305
136cytokine biosynthetic process (GO:0042089)2.34751283
137neutrophil activation (GO:0042119)2.34182205
138regulation of podosome assembly (GO:0071801)2.33973264
139positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.33118017
140regulation of alpha-beta T cell proliferation (GO:0046640)2.32741318
141cholesterol efflux (GO:0033344)2.32080311
142response to muramyl dipeptide (GO:0032495)2.32042034
143DNA deamination (GO:0045006)2.31591361
144response to fungus (GO:0009620)2.30050261
145myeloid dendritic cell activation (GO:0001773)2.29439328
146flavonoid metabolic process (GO:0009812)2.29242054
147regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.28789292
148cellular response to dsRNA (GO:0071359)2.28469460
149positive regulation of response to cytokine stimulus (GO:0060760)2.28459500
150alkaloid metabolic process (GO:0009820)2.27188450
151myeloid dendritic cell differentiation (GO:0043011)2.25620380
152detection of other organism (GO:0098543)2.24877643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.92822798
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.69794986
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.21331680
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.99377141
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73301902
6VDR_21846776_ChIP-Seq_THP-1_Human2.61236545
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.60776586
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.50184562
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.50061907
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49839704
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.47264068
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46989908
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.43799259
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40584505
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34065778
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33703812
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33477298
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07580196
19* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.05425971
20BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99672588
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.95278622
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87570591
23MAF_26560356_Chip-Seq_TH1_Human1.86618508
24MYC_22102868_ChIP-Seq_BL_Human1.86443342
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.86429988
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.86276775
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85455816
28VDR_24763502_ChIP-Seq_THP-1_Human1.83787928
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.82167831
30SPI1_23547873_ChIP-Seq_NB4_Human1.78569498
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.76392303
32* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75025071
33SCL_19346495_ChIP-Seq_HPC-7_Human1.72852365
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.71784591
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66367364
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.65257149
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63543845
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63366074
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62109195
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59580284
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58774929
42SRY_22984422_ChIP-ChIP_TESTIS_Rat1.58512171
43UTX_26944678_Chip-Seq_JUKART_Human1.58323549
44LXR_22292898_ChIP-Seq_THP-1_Human1.58237418
45E2F7_22180533_ChIP-Seq_HELA_Human1.57507758
46MYB_26560356_Chip-Seq_TH2_Human1.56822660
47CDX2_20551321_ChIP-Seq_CACO-2_Human1.56803866
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56737798
49MYB_26560356_Chip-Seq_TH1_Human1.53914073
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49691911
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.49632118
52TCF7_22412390_ChIP-Seq_EML_Mouse1.46622270
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.45924993
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45861584
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45820255
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42967182
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39624669
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37499370
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36450272
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33927629
61SPI1_23127762_ChIP-Seq_K562_Human1.33679898
62EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.32862193
63PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30919087
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27687087
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.25960282
66MAF_26560356_Chip-Seq_TH2_Human1.24506963
67* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23808455
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22907916
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22832596
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22012097
71GATA3_27048872_Chip-Seq_THYMUS_Human1.20973791
72* PU_27001747_Chip-Seq_BMDM_Mouse1.20536256
73VDR_24787735_ChIP-Seq_THP-1_Human1.19225289
74P68_20966046_ChIP-Seq_HELA_Human1.18534326
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18030107
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16938603
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16310635
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14642706
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14406407
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.13800158
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13593006
82RUNX_20019798_ChIP-Seq_JUKART_Human1.13586759
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12910872
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12813729
85* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11947205
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11887181
87* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11705740
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11136544
89BCL6_27268052_Chip-Seq_Bcells_Human1.11004512
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.10867936
91* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10055889
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10003257
93* RACK7_27058665_Chip-Seq_MCF-7_Human1.09951437
94* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07352872
95GATA1_22025678_ChIP-Seq_K562_Human1.06176189
96GATA1_19941826_ChIP-Seq_K562_Human1.05877551
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05039609
98GATA3_26560356_Chip-Seq_TH2_Human1.04713461
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03683108
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03268739
101KDM2B_26808549_Chip-Seq_DND41_Human1.02580021
102SA1_27219007_Chip-Seq_Bcells_Human1.01285631
103KDM2B_26808549_Chip-Seq_JURKAT_Human0.99938117
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99647686
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98219880
106RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97434064
107P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97297665
108CTCF_26484167_Chip-Seq_Bcells_Mouse0.96821077
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96681368
110BCOR_27268052_Chip-Seq_Bcells_Human0.96557599
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94634094
112P300_27268052_Chip-Seq_Bcells_Human0.94590469
113PHF8_20622854_ChIP-Seq_HELA_Human0.94104102
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92337913
115LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92041934
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91681961
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91599868
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90003868
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89181119
120SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88289435
121* NCOR1_26117541_ChIP-Seq_K562_Human0.87692321
122TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87646388

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.34119079
2MP0000685_abnormal_immune_system3.07038766
3MP0005360_urolithiasis3.06063020
4MP0009785_altered_susceptibility_to2.72881573
5MP0003436_decreased_susceptibility_to2.71438157
6MP0003191_abnormal_cellular_cholesterol2.51593312
7MP0005025_abnormal_response_to2.40672536
8MP0009840_abnormal_foam_cell2.31152947
9MP0008260_abnormal_autophagy2.29489891
10MP0006082_CNS_inflammation2.24823546
11MP0005671_abnormal_response_to2.21113840
12MP0001790_abnormal_immune_system2.18571660
13MP0005387_immune_system_phenotype2.18571660
14MP0001800_abnormal_humoral_immune2.17813493
15MP0001873_stomach_inflammation2.16082431
16MP0002419_abnormal_innate_immunity2.14893982
17MP0009278_abnormal_bone_marrow2.14639250
18MP0010155_abnormal_intestine_physiology2.14156723
19MP0005085_abnormal_gallbladder_physiolo2.12999191
20MP0002148_abnormal_hypersensitivity_rea2.11501757
21MP0002166_altered_tumor_susceptibility2.09957828
22MP0005058_abnormal_lysosome_morphology2.06645329
23MP0002452_abnormal_antigen_presenting2.05845593
24MP0005464_abnormal_platelet_physiology2.03517460
25MP0003724_increased_susceptibility_to2.01151035
26MP0005000_abnormal_immune_tolerance2.00992839
27MP0002139_abnormal_hepatobiliary_system1.96070120
28MP0002723_abnormal_immune_serum1.95823615
29MP0001851_eye_inflammation1.92583890
30MP0005365_abnormal_bile_salt1.92044979
31MP0001819_abnormal_immune_cell1.85015025
32MP0005397_hematopoietic_system_phenotyp1.84306507
33MP0001545_abnormal_hematopoietic_system1.84306507
34MP0001666_abnormal_nutrient_absorption1.83734456
35MP0002420_abnormal_adaptive_immunity1.83348414
36MP0002405_respiratory_system_inflammati1.82791216
37MP0003303_peritoneal_inflammation1.81897298
38MP0002396_abnormal_hematopoietic_system1.74104165
39MP0004947_skin_inflammation1.64945137
40MP0008875_abnormal_xenobiotic_pharmacok1.63999903
41MP0002006_tumorigenesis1.63269358
42MP0001845_abnormal_inflammatory_respons1.60891656
43MP0009333_abnormal_splenocyte_physiolog1.58992604
44MP0010352_gastrointestinal_tract_polyps1.57460917
45MP0002398_abnormal_bone_marrow1.55241500
46MP0003866_abnormal_defecation1.55214420
47MP0000490_abnormal_crypts_of1.53299988
48MP0000716_abnormal_immune_system1.52885058
49MP0008469_abnormal_protein_level1.50621573
50MP0001853_heart_inflammation1.49225421
51MP0003763_abnormal_thymus_physiology1.47589506
52MP0000689_abnormal_spleen_morphology1.47050679
53MP0003252_abnormal_bile_duct1.44020632
54MP0003172_abnormal_lysosome_physiology1.40961477
55MP0003806_abnormal_nucleotide_metabolis1.36817401
56MP0002138_abnormal_hepatobiliary_system1.32565428
57MP0005174_abnormal_tail_pigmentation1.31866224
58MP0002429_abnormal_blood_cell1.31512779
59MP0001533_abnormal_skeleton_physiology1.31386202
60MP0002722_abnormal_immune_system1.31206992
61MP0003300_gastrointestinal_ulcer1.29358494
62MP0000609_abnormal_liver_physiology1.25519674
63MP0010329_abnormal_lipoprotein_level1.24795464
64MP0002998_abnormal_bone_remodeling1.24663438
65MP0005451_abnormal_body_composition1.18607670
66MP0003453_abnormal_keratinocyte_physiol1.11935601
67MP0009764_decreased_sensitivity_to1.11399682
68MP0003075_altered_response_to1.10913113
69MP0005075_abnormal_melanosome_morpholog1.10205527
70MP0003183_abnormal_peptide_metabolism1.08669714
71MP0005167_abnormal_blood-brain_barrier1.07723390
72MP0008057_abnormal_DNA_replication1.06803487
73MP0002254_reproductive_system_inflammat1.06690635
74MP0000465_gastrointestinal_hemorrhage1.06610889
75MP0005023_abnormal_wound_healing1.06594435
76MP0004510_myositis1.02135229
77MP0003656_abnormal_erythrocyte_physiolo1.01704936
78MP0000343_altered_response_to1.01561200
79MP0002877_abnormal_melanocyte_morpholog0.98099573
80MP0003690_abnormal_glial_cell0.98087132
81MP0005319_abnormal_enzyme/_coenzyme0.97251868
82MP0005310_abnormal_salivary_gland0.96857665
83MP0001663_abnormal_digestive_system0.95940941
84MP0004019_abnormal_vitamin_homeostasis0.95507968
85MP0002132_abnormal_respiratory_system0.91706474
86MP0003448_altered_tumor_morphology0.91469882
87MP0000477_abnormal_intestine_morphology0.90666065
88MP0005166_decreased_susceptibility_to0.89949443
89MP0000858_altered_metastatic_potential0.88496121
90MP0004264_abnormal_extraembryonic_tissu0.86935708
91MP0005076_abnormal_cell_differentiation0.85815545
92MP0003705_abnormal_hypodermis_morpholog0.85328043
93MP0010307_abnormal_tumor_latency0.83944721
94MP0009763_increased_sensitivity_to0.83437525
95MP0000598_abnormal_liver_morphology0.82915675
96MP0001764_abnormal_homeostasis0.82907653
97MP0003795_abnormal_bone_structure0.82534884
98MP0005390_skeleton_phenotype0.82200084
99MP0000604_amyloidosis0.81496700
100MP0002933_joint_inflammation0.81161286
101MP0004782_abnormal_surfactant_physiolog0.80508535
102MP0000371_diluted_coat_color0.80377336
103MP0000249_abnormal_blood_vessel0.79388397
104MP0002277_abnormal_respiratory_mucosa0.78333838
105MP0003045_fibrosis0.77213854
106MP0005381_digestive/alimentary_phenotyp0.76462207
107MP0002019_abnormal_tumor_incidence0.76299078
108MP0003828_pulmonary_edema0.75843745
109MP0005584_abnormal_enzyme/coenzyme_acti0.75111695
110MP0009643_abnormal_urine_homeostasis0.73989824
111MP0000703_abnormal_thymus_morphology0.73373752
112MP0008004_abnormal_stomach_pH0.71813848
113MP0003329_amyloid_beta_deposits0.70373298
114MP0005164_abnormal_response_to0.70341782
115MP0005165_increased_susceptibility_to0.69742607
116MP0002136_abnormal_kidney_physiology0.67006739
117MP0004381_abnormal_hair_follicle0.66569659
118MP0004883_abnormal_blood_vessel0.65804010
119MP0009765_abnormal_xenobiotic_induced0.60966565
120MP0003195_calcinosis0.59985441
121MP0009115_abnormal_fat_cell0.57333888

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.05946945
2Recurrent abscess formation (HP:0002722)4.54208233
3Eczematoid dermatitis (HP:0000976)4.49031569
4Recurrent bacterial skin infections (HP:0005406)4.16703107
5Recurrent gram-negative bacterial infections (HP:0005420)3.84176147
6Autoimmune thrombocytopenia (HP:0001973)3.76476792
7Recurrent fungal infections (HP:0002841)3.72588985
8Elevated erythrocyte sedimentation rate (HP:0003565)3.71397605
9Polycythemia (HP:0001901)3.68700922
10Systemic lupus erythematosus (HP:0002725)3.35940890
11Vacuolated lymphocytes (HP:0001922)3.34944591
12Myositis (HP:0100614)3.18497910
13Colitis (HP:0002583)3.08656513
14Mucopolysacchariduria (HP:0008155)3.03819825
15Urinary glycosaminoglycan excretion (HP:0003541)3.03819825
16Dysostosis multiplex (HP:0000943)3.03721066
17Increased IgM level (HP:0003496)3.03612501
18Chronic otitis media (HP:0000389)2.95824323
19Abnormality of macrophages (HP:0004311)2.95479868
20Recurrent skin infections (HP:0001581)2.94719154
21Recurrent viral infections (HP:0004429)2.94580259
22Abnormality of T cell number (HP:0011839)2.89587962
23Encephalitis (HP:0002383)2.89345347
24Pulmonary infiltrates (HP:0002113)2.79728834
25Inflammation of the large intestine (HP:0002037)2.78777635
26Abnormality of mucopolysaccharide metabolism (HP:0011020)2.76317731
27Abnormality of polysaccharide metabolism (HP:0011012)2.76317731
28Abnormality of glycosaminoglycan metabolism (HP:0004371)2.76317731
29Panhypogammaglobulinemia (HP:0003139)2.75666700
30Thrombocytosis (HP:0001894)2.74290893
31Abnormality of T cell physiology (HP:0011840)2.72527227
32Myocardial infarction (HP:0001658)2.71248408
33Pulmonary embolism (HP:0002204)2.68923583
34Gastrointestinal inflammation (HP:0004386)2.68650763
35Cheilitis (HP:0100825)2.68043182
36Gingivitis (HP:0000230)2.67590509
37Mediastinal lymphadenopathy (HP:0100721)2.67522688
38Hypochromic anemia (HP:0001931)2.67472531
39Malnutrition (HP:0004395)2.63300928
40Hypobetalipoproteinemia (HP:0003563)2.62653187
41Poikiloderma (HP:0001029)2.61112770
42Nasal polyposis (HP:0100582)2.60745882
43Tongue fasciculations (HP:0001308)2.60514410
44Abnormality of the nasal mucosa (HP:0000433)2.58852615
45Alopecia of scalp (HP:0002293)2.54080610
46Periodontitis (HP:0000704)2.52206389
47Abnormality of monocarboxylic acid metabolism (HP:0010996)2.49761732
48Gingival bleeding (HP:0000225)2.49441280
49Petechiae (HP:0000967)2.46575957
50Hypergammaglobulinemia (HP:0010702)2.45283941
51Spontaneous hematomas (HP:0007420)2.43316882
52Orchitis (HP:0100796)2.42986359
53Agammaglobulinemia (HP:0004432)2.41066023
54Interstitial pulmonary disease (HP:0006530)2.40961346
55Intrahepatic cholestasis (HP:0001406)2.38734504
56Keratoconjunctivitis sicca (HP:0001097)2.38389059
57Chest pain (HP:0100749)2.37658302
58Increased serum ferritin (HP:0003281)2.37275926
59Amyloidosis (HP:0011034)2.37076463
60Complement deficiency (HP:0004431)2.36363649
61Purpura (HP:0000979)2.35830937
62Abnormality of T cells (HP:0002843)2.35315358
63Epistaxis (HP:0000421)2.35007172
64Albinism (HP:0001022)2.33700305
65Vasculitis (HP:0002633)2.32450476
66IgM deficiency (HP:0002850)2.32254475
67Increased IgE level (HP:0003212)2.32096298
68Abnormality of iron homeostasis (HP:0011031)2.31972913
69Gastrointestinal stroma tumor (HP:0100723)2.30837377
70Chronic mucocutaneous candidiasis (HP:0002728)2.30603017
71Recurrent cutaneous fungal infections (HP:0011370)2.30603017
72Abnormal platelet volume (HP:0011876)2.30270107
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.30180193
74Abnormality of glutamine family amino acid metabolism (HP:0010902)2.29227281
75Glomerulonephritis (HP:0000099)2.28683669
76Muscle fibrillation (HP:0010546)2.28537224
77Joint hemorrhage (HP:0005261)2.25745821
78Gastrointestinal dysmotility (HP:0002579)2.24997681
79Recurrent bronchitis (HP:0002837)2.23554984
80Abnormality of complement system (HP:0005339)2.22948897
81Obstructive lung disease (HP:0006536)2.22122276
82Chronic obstructive pulmonary disease (HP:0006510)2.22122276
83Abnormality of eosinophils (HP:0001879)2.21009408
84Chronic diarrhea (HP:0002028)2.20335133
85Polygenic inheritance (HP:0010982)2.20101019
86Restrictive lung disease (HP:0002091)2.18300759
87Keratoconjunctivitis (HP:0001096)2.17892248
88Increased neuronal autofluorescent lipopigment (HP:0002074)2.16666407
89T lymphocytopenia (HP:0005403)2.13060701
90Meningitis (HP:0001287)2.12866254
91Nephritis (HP:0000123)2.12806793
92IgA deficiency (HP:0002720)2.11835399
93Facial hemangioma (HP:0000329)2.11256498
94Increased mean platelet volume (HP:0011877)2.09969955
95Abnormal delayed hypersensitivity skin test (HP:0002963)2.08855719
96Cupped ribs (HP:0000887)2.08542496
97Esophageal varix (HP:0002040)2.08489592
98Cellulitis (HP:0100658)2.07212294
99Xanthomatosis (HP:0000991)2.05459323
100Abnormal platelet function (HP:0011869)2.05269434
101Impaired platelet aggregation (HP:0003540)2.05269434
102Leukocytosis (HP:0001974)2.02006429
103Metaphyseal cupping (HP:0003021)2.01870316
104Urticaria (HP:0001025)2.00999157
105Anorexia (HP:0002039)2.00696915
106Bronchitis (HP:0012387)2.00536417
107Gangrene (HP:0100758)2.00004191
108Premature loss of primary teeth (HP:0006323)1.99242124
109Microcytic anemia (HP:0001935)1.99141222
110Fat malabsorption (HP:0002630)1.98554420
111Lymphopenia (HP:0001888)1.98085177
112Prolonged bleeding time (HP:0003010)1.97884400
113Stomatitis (HP:0010280)1.97616697
114Hemorrhage of the eye (HP:0011885)1.96979709
115Abnormality of glycolipid metabolism (HP:0010969)1.96542434
116Abnormality of liposaccharide metabolism (HP:0010968)1.96542434
117Abnormality of glycosphingolipid metabolism (HP:0004343)1.96542434
118Autoimmune hemolytic anemia (HP:0001890)1.95988291
119Deep venous thrombosis (HP:0002625)1.95094990
120Combined immunodeficiency (HP:0005387)1.94602664
121Increased cerebral lipofuscin (HP:0011813)1.94521928
122Emphysema (HP:0002097)1.94166663
123Thrombophlebitis (HP:0004418)1.93705619
124Arterial thrombosis (HP:0004420)1.92970616
125Hypertriglyceridemia (HP:0002155)1.92488664
126Sparse scalp hair (HP:0002209)1.91897192
127Abnormality of the pleura (HP:0002103)1.91521858
128Osteomyelitis (HP:0002754)1.91431705
129Eosinophilia (HP:0001880)1.91241660
130Retrobulbar optic neuritis (HP:0100654)1.89482306
131Optic neuritis (HP:0100653)1.89482306
132Abnormality of transition element cation homeostasis (HP:0011030)1.89291084
133Severe combined immunodeficiency (HP:0004430)1.88285594
134Hemoptysis (HP:0002105)1.87449883
135Ureteral stenosis (HP:0000071)1.87001155
136Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86150437
137Granulocytopenia (HP:0001913)1.85932518
138Skin ulcer (HP:0200042)1.84831719
139Gastrointestinal infarctions (HP:0005244)1.82574010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TBK14.32358313
2MAP4K13.21656973
3IKBKE3.06489639
4TYK22.80201586
5PIM22.60188381
6BLK2.51210310
7PRKCH2.35365513
8MAP3K142.32616547
9ERN12.30133524
10CSK2.29813179
11PRPF4B2.17198538
12MAP3K112.08556623
13KIT1.99988988
14IKBKB1.98610317
15GRK61.89964547
16MATK1.89771604
17JAK31.88829674
18MAPK151.79655005
19IRAK41.73373178
20ICK1.70429944
21MAP3K61.67435773
22ZAP701.66431528
23TNK21.60565134
24FGR1.58708098
25TXK1.56558628
26EPHA31.52704986
27MST41.52538513
28FGFR41.51806116
29PIM11.51036306
30FLT31.47156230
31STK101.42042278
32PBK1.41963974
33DDR21.41795020
34CSF1R1.39393352
35JAK11.38951900
36MAP2K31.37806638
37MAP3K11.36091824
38TGFBR21.33471755
39BTK1.32110651
40TAOK31.30554846
41MAP3K131.28988501
42MAP3K101.25096246
43RIPK41.20040595
44MAPK111.15417669
45KDR1.14924791
46IRAK31.12314408
47TEC1.11869191
48BMX1.11753457
49EPHB11.08436601
50SMG11.05922036
51LCK1.03725864
52LYN1.00841791
53TRPM71.00337375
54SYK0.97525665
55DYRK1B0.95540753
56NME20.93782527
57TAOK10.92268177
58JAK20.92259809
59RIPK10.91115402
60PKN20.90352280
61PTK60.90297359
62TRIB30.88888326
63CDK60.88488989
64CHUK0.87801901
65CDC42BPA0.87241134
66IRAK10.85391595
67HIPK20.85047870
68PRKG20.84716825
69RPS6KA60.83590585
70LRRK20.82693518
71HCK0.82209692
72RPS6KL10.81941797
73RPS6KC10.81941797
74DAPK10.80039140
75YES10.79813494
76TGFBR10.76315513
77MST1R0.76111815
78ITK0.74184126
79TYRO30.72780053
80SIK30.71690808
81MAP3K30.70122036
82PRKCQ0.69889162
83PRKD20.66470366
84TAOK20.65163557
85EPHA20.64291647
86RPS6KA20.63928183
87PAK40.63816937
88MAP3K80.63556629
89ARAF0.63200698
90MARK20.62248682
91CDK70.61926508
92MAP3K20.57543496
93KSR20.57479528
94MAP3K70.56347610
95MAPK40.55936712
96RET0.54043361
97FES0.53719683
98PDPK10.52046460
99MAPKAPK20.50332115
100PRKAA20.49847329
101TESK20.49082373
102MAPK70.48905904
103FYN0.48463363
104PDK10.48112289
105GRK70.47877760
106TESK10.47853684
107BCKDK0.46512492
108PRKCD0.46050691
109EGFR0.45827229
110ABL10.44716250
111RPS6KA40.44492188
112RAF10.44077819
113FGFR30.42333888
114SIK10.40440221
115MAPK120.39414472
116TTN0.38061599
117RPS6KA10.37889863
118EEF2K0.37341730
119GSK3A0.37245416
120MAPK30.36546419
121NEK90.36055950
122MARK30.35540814
123RPS6KB20.35503981
124STK380.35235643
125MAP2K20.34838442
126MAP2K60.34463747
127SIK20.34194356
128NLK0.32750410

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053203.18136446
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.79713703
3Staphylococcus aureus infection_Homo sapiens_hsa051502.63155482
4Type I diabetes mellitus_Homo sapiens_hsa049402.45295629
5Caffeine metabolism_Homo sapiens_hsa002322.30393617
6Primary immunodeficiency_Homo sapiens_hsa053402.27248531
7Leishmaniasis_Homo sapiens_hsa051402.21101593
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.10256512
9Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98027769
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91175205
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.86351793
12Measles_Homo sapiens_hsa051621.83985039
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.81143438
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.80112366
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79657231
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72899386
17Pertussis_Homo sapiens_hsa051331.70360876
18Legionellosis_Homo sapiens_hsa051341.68176875
19Fat digestion and absorption_Homo sapiens_hsa049751.67277929
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.56811084
21Rheumatoid arthritis_Homo sapiens_hsa053231.54318524
22Osteoclast differentiation_Homo sapiens_hsa043801.48620008
23Complement and coagulation cascades_Homo sapiens_hsa046101.47733784
24Herpes simplex infection_Homo sapiens_hsa051681.42708661
25B cell receptor signaling pathway_Homo sapiens_hsa046621.39356479
26Antigen processing and presentation_Homo sapiens_hsa046121.39153738
27Galactose metabolism_Homo sapiens_hsa000521.38231037
28Other glycan degradation_Homo sapiens_hsa005111.33920767
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.33442727
30Arginine biosynthesis_Homo sapiens_hsa002201.31275852
31Base excision repair_Homo sapiens_hsa034101.31033849
32Influenza A_Homo sapiens_hsa051641.28679773
33Shigellosis_Homo sapiens_hsa051311.27274296
34Starch and sucrose metabolism_Homo sapiens_hsa005001.23420570
35Folate biosynthesis_Homo sapiens_hsa007901.23093611
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22357424
37Allograft rejection_Homo sapiens_hsa053301.16884717
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16604277
39Fatty acid biosynthesis_Homo sapiens_hsa000611.13872928
40Mineral absorption_Homo sapiens_hsa049781.13047117
41Tuberculosis_Homo sapiens_hsa051521.12900305
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12898975
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12608439
44Toxoplasmosis_Homo sapiens_hsa051451.12300217
45Histidine metabolism_Homo sapiens_hsa003401.11848794
46Sulfur relay system_Homo sapiens_hsa041221.10631989
47ABC transporters_Homo sapiens_hsa020101.10516273
48Fructose and mannose metabolism_Homo sapiens_hsa000511.10067070
49Hematopoietic cell lineage_Homo sapiens_hsa046401.08814492
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.07958458
51Tryptophan metabolism_Homo sapiens_hsa003801.06196824
52Phagosome_Homo sapiens_hsa041451.04829787
53Renin-angiotensin system_Homo sapiens_hsa046141.04741744
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.04045217
55Hepatitis C_Homo sapiens_hsa051601.03917223
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.03244524
57Apoptosis_Homo sapiens_hsa042101.02521921
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01891226
59TNF signaling pathway_Homo sapiens_hsa046681.01806416
60Salmonella infection_Homo sapiens_hsa051321.00175119
61Vitamin digestion and absorption_Homo sapiens_hsa049770.99520092
62DNA replication_Homo sapiens_hsa030300.98890283
63Malaria_Homo sapiens_hsa051440.97642443
64Graft-versus-host disease_Homo sapiens_hsa053320.96361788
65Non-small cell lung cancer_Homo sapiens_hsa052230.93775004
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93142015
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.93108414
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91388518
69Hepatitis B_Homo sapiens_hsa051610.87667581
70Sulfur metabolism_Homo sapiens_hsa009200.86594867
71Pentose phosphate pathway_Homo sapiens_hsa000300.86515078
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86403139
73Viral myocarditis_Homo sapiens_hsa054160.86164900
74Lysosome_Homo sapiens_hsa041420.85934893
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.83717762
76Acute myeloid leukemia_Homo sapiens_hsa052210.82603171
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81910047
78Amoebiasis_Homo sapiens_hsa051460.80349373
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80255301
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.79676412
81Arachidonic acid metabolism_Homo sapiens_hsa005900.79237339
82Glycerolipid metabolism_Homo sapiens_hsa005610.78285590
83African trypanosomiasis_Homo sapiens_hsa051430.77809626
84PPAR signaling pathway_Homo sapiens_hsa033200.77460700
85Mismatch repair_Homo sapiens_hsa034300.76305604
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75856707
87Selenocompound metabolism_Homo sapiens_hsa004500.74102748
88Steroid biosynthesis_Homo sapiens_hsa001000.72384195
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69107429
90Linoleic acid metabolism_Homo sapiens_hsa005910.68788018
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68200860
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65180524
93Fatty acid degradation_Homo sapiens_hsa000710.63836241
94Chemokine signaling pathway_Homo sapiens_hsa040620.63520267
95Prion diseases_Homo sapiens_hsa050200.62521801
96Platelet activation_Homo sapiens_hsa046110.62043070
97Chemical carcinogenesis_Homo sapiens_hsa052040.62015972
98Pancreatic cancer_Homo sapiens_hsa052120.60380366
99Bile secretion_Homo sapiens_hsa049760.60117053
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.59731151
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59644717
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54824569
103p53 signaling pathway_Homo sapiens_hsa041150.54033218
104Arginine and proline metabolism_Homo sapiens_hsa003300.53811141
105HTLV-I infection_Homo sapiens_hsa051660.53193052
106Peroxisome_Homo sapiens_hsa041460.53123489
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51514146
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50862237
109Biosynthesis of amino acids_Homo sapiens_hsa012300.49490892
110T cell receptor signaling pathway_Homo sapiens_hsa046600.48778747
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.48773881
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48674931
113Insulin resistance_Homo sapiens_hsa049310.48363220
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48018499
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47084437
116Prolactin signaling pathway_Homo sapiens_hsa049170.46791693
117Asthma_Homo sapiens_hsa053100.45729148
118Small cell lung cancer_Homo sapiens_hsa052220.45058289
119Chronic myeloid leukemia_Homo sapiens_hsa052200.44958327
120VEGF signaling pathway_Homo sapiens_hsa043700.44140106
121Epstein-Barr virus infection_Homo sapiens_hsa051690.43790845
122Glutathione metabolism_Homo sapiens_hsa004800.43566405
123Viral carcinogenesis_Homo sapiens_hsa052030.43216532
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42640836
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.38930979
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.38324901
127Choline metabolism in cancer_Homo sapiens_hsa052310.38235876
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.35835865
129Systemic lupus erythematosus_Homo sapiens_hsa053220.35199983
130Bladder cancer_Homo sapiens_hsa052190.34790712
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34281038
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.29542256
133Notch signaling pathway_Homo sapiens_hsa043300.27520721

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