

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | regulation of histone H3-K27 methylation (GO:0061085) | 5.19527830 |
| 2 | positive regulation of histone deacetylation (GO:0031065) | 4.95135742 |
| 3 | cytoplasmic mRNA processing body assembly (GO:0033962) | 3.99049550 |
| 4 | negative regulation of histone methylation (GO:0031061) | 3.90768648 |
| 5 | pre-miRNA processing (GO:0031054) | 3.84636877 |
| 6 | positive regulation of gene expression, epigenetic (GO:0045815) | 3.78818931 |
| 7 | histone H3-K4 methylation (GO:0051568) | 3.74896874 |
| 8 | regulation of chromatin binding (GO:0035561) | 3.71286780 |
| 9 | mitotic chromosome condensation (GO:0007076) | 3.61588086 |
| 10 | regulation of nucleobase-containing compound transport (GO:0032239) | 3.60870043 |
| 11 | embryonic camera-type eye morphogenesis (GO:0048596) | 3.60053272 |
| 12 | glucocorticoid receptor signaling pathway (GO:0042921) | 3.58944761 |
| 13 | histone H3-K4 trimethylation (GO:0080182) | 3.56554337 |
| 14 | regulation of NFAT protein import into nucleus (GO:0051532) | 3.55776268 |
| 15 | positive regulation of RNA splicing (GO:0033120) | 3.54768856 |
| 16 | biotin metabolic process (GO:0006768) | 3.51453589 |
| 17 | peptidyl-lysine dimethylation (GO:0018027) | 3.50485620 |
| 18 | intracellular estrogen receptor signaling pathway (GO:0030520) | 3.48077386 |
| 19 | embryonic retina morphogenesis in camera-type eye (GO:0060059) | 3.40863125 |
| 20 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.38708667 |
| 21 | DNA topological change (GO:0006265) | 3.37637807 |
| 22 | histone H3-K36 demethylation (GO:0070544) | 3.35518982 |
| 23 | nucleosome disassembly (GO:0006337) | 3.35355773 |
| 24 | protein-DNA complex disassembly (GO:0032986) | 3.35355773 |
| 25 | positive regulation of protein deacetylation (GO:0090312) | 3.33044068 |
| 26 | face development (GO:0060324) | 3.28435744 |
| 27 | histone H3-K9 demethylation (GO:0033169) | 3.28430445 |
| 28 | regulation of fatty acid beta-oxidation (GO:0031998) | 3.26837640 |
| 29 | embryonic eye morphogenesis (GO:0048048) | 3.26450495 |
| 30 | histone lysine methylation (GO:0034968) | 3.26205629 |
| 31 | DNA unwinding involved in DNA replication (GO:0006268) | 3.23523017 |
| 32 | sodium ion export (GO:0071436) | 3.20027936 |
| 33 | stress granule assembly (GO:0034063) | 3.19403141 |
| 34 | nuclear pore complex assembly (GO:0051292) | 3.19356606 |
| 35 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.10678380 |
| 36 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 3.07344877 |
| 37 | regulation of ARF protein signal transduction (GO:0032012) | 3.06867078 |
| 38 | definitive hemopoiesis (GO:0060216) | 3.06499540 |
| 39 | ear development (GO:0043583) | 3.02920369 |
| 40 | negative regulation of cell size (GO:0045792) | 2.99072271 |
| 41 | histone H4-K16 acetylation (GO:0043984) | 2.97114418 |
| 42 | peptidyl-lysine trimethylation (GO:0018023) | 2.96627335 |
| 43 | positive thymic T cell selection (GO:0045059) | 2.95973296 |
| 44 | histone lysine demethylation (GO:0070076) | 2.93443839 |
| 45 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 2.93288496 |
| 46 | corticosteroid receptor signaling pathway (GO:0031958) | 2.93098009 |
| 47 | chromatin silencing (GO:0006342) | 2.90052079 |
| 48 | cell migration in hindbrain (GO:0021535) | 2.89044326 |
| 49 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr | 2.88370131 |
| 50 | maternal placenta development (GO:0001893) | 2.86696997 |
| 51 | megakaryocyte development (GO:0035855) | 2.86630439 |
| 52 | RNA localization (GO:0006403) | 2.85376037 |
| 53 | regulation of histone H3-K4 methylation (GO:0051569) | 2.84862941 |
| 54 | histone H4-K12 acetylation (GO:0043983) | 2.83443535 |
| 55 | L-alpha-amino acid transmembrane transport (GO:1902475) | 2.83190020 |
| 56 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.82994682 |
| 57 | RNA stabilization (GO:0043489) | 2.81954318 |
| 58 | mRNA stabilization (GO:0048255) | 2.81954318 |
| 59 | histone methylation (GO:0016571) | 2.80461660 |
| 60 | embryonic hemopoiesis (GO:0035162) | 2.80366566 |
| 61 | positive regulation of Rap GTPase activity (GO:0032854) | 2.79741791 |
| 62 | activation of signaling protein activity involved in unfolded protein response (GO:0006987) | 2.79330635 |
| 63 | trophectodermal cell differentiation (GO:0001829) | 2.78530985 |
| 64 | regulation of branching involved in prostate gland morphogenesis (GO:0060687) | 2.78302532 |
| 65 | histone H3-K9 methylation (GO:0051567) | 2.77437404 |
| 66 | negative regulation of gene expression, epigenetic (GO:0045814) | 2.77125186 |
| 67 | positive regulation of transcription from RNA polymerase III promoter (GO:0045945) | 2.75882213 |
| 68 | regulation of histone H3-K9 methylation (GO:0051570) | 2.75138806 |
| 69 | regulation of histone deacetylation (GO:0031063) | 2.74587737 |
| 70 | histone demethylation (GO:0016577) | 2.74418815 |
| 71 | positive regulation of nuclease activity (GO:0032075) | 2.74188363 |
| 72 | glandular epithelial cell development (GO:0002068) | 2.74105703 |
| 73 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 2.73264038 |
| 74 | positive T cell selection (GO:0043368) | 2.73238302 |
| 75 | DNA methylation (GO:0006306) | 2.72947736 |
| 76 | DNA alkylation (GO:0006305) | 2.72947736 |
| 77 | regulation of ARF GTPase activity (GO:0032312) | 2.72849050 |
| 78 | regulation of translational fidelity (GO:0006450) | 2.72286433 |
| 79 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.72251524 |
| 80 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.72251524 |
| 81 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.72251524 |
| 82 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 2.71746051 |
| 83 | heterochromatin organization (GO:0070828) | 2.71445466 |
| 84 | COPI coating of Golgi vesicle (GO:0048205) | 2.71336932 |
| 85 | Golgi transport vesicle coating (GO:0048200) | 2.71336932 |
| 86 | regulation of glucose import in response to insulin stimulus (GO:2001273) | 2.66111488 |
| 87 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 2.65902029 |
| 88 | atrioventricular valve morphogenesis (GO:0003181) | 2.65848668 |
| 89 | response to epidermal growth factor (GO:0070849) | 2.65713173 |
| 90 | genetic imprinting (GO:0071514) | 2.65638596 |
| 91 | nuclear pore organization (GO:0006999) | 2.64789267 |
| 92 | mRNA cleavage (GO:0006379) | 2.62048005 |
| 93 | gene silencing (GO:0016458) | 2.61980697 |
| 94 | protein dealkylation (GO:0008214) | 2.61502487 |
| 95 | protein demethylation (GO:0006482) | 2.61502487 |
| 96 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.61494247 |
| 97 | regulation of gamma-delta T cell activation (GO:0046643) | 2.60434417 |
| 98 | mitotic sister chromatid cohesion (GO:0007064) | 2.58678454 |
| 99 | peptidyl-lysine methylation (GO:0018022) | 2.57801456 |
| 100 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151) | 2.54323859 |
| 101 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO | 2.54323859 |
| 102 | TOR signaling (GO:0031929) | 2.52840212 |
| 103 | regulation of erythrocyte differentiation (GO:0045646) | 2.51913443 |
| 104 | regulation of mRNA catabolic process (GO:0061013) | 2.51847377 |
| 105 | type B pancreatic cell development (GO:0003323) | 2.51399429 |
| 106 | proline biosynthetic process (GO:0006561) | 2.51281885 |
| 107 | sister chromatid segregation (GO:0000819) | 2.49878102 |
| 108 | positive regulation of gamma-delta T cell activation (GO:0046645) | 2.49228621 |
| 109 | regulation of nuclease activity (GO:0032069) | 2.49074647 |
| 110 | histone H4-K5 acetylation (GO:0043981) | 2.48945405 |
| 111 | histone H4-K8 acetylation (GO:0043982) | 2.48945405 |
| 112 | cardiac right ventricle morphogenesis (GO:0003215) | 2.48099604 |
| 113 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.47450070 |
| 114 | regulation of centriole replication (GO:0046599) | 2.47414047 |
| 115 | positive regulation by host of viral transcription (GO:0043923) | 2.46328089 |
| 116 | adaptation of signaling pathway (GO:0023058) | 2.46286340 |
| 117 | histone H4 acetylation (GO:0043967) | 2.46134654 |
| 118 | desmosome organization (GO:0002934) | 2.45833390 |
| 119 | histone H4 deacetylation (GO:0070933) | 2.45559238 |
| 120 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 2.45380248 |
| 121 | peptidyl-threonine phosphorylation (GO:0018107) | 2.45286650 |
| 122 | platelet formation (GO:0030220) | 2.45261072 |
| 123 | positive regulation of cell cycle G2/M phase transition (GO:1902751) | 2.45185609 |
| 124 | positive regulation of G2/M transition of mitotic cell cycle (GO:0010971) | 2.45185609 |
| 125 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.44562896 |
| 126 | positive regulation of mRNA catabolic process (GO:0061014) | 2.44513909 |
| 127 | layer formation in cerebral cortex (GO:0021819) | 2.44385626 |
| 128 | NLS-bearing protein import into nucleus (GO:0006607) | 2.44153072 |
| 129 | negative regulation of mRNA metabolic process (GO:1903312) | 2.44111430 |
| 130 | regulation of protein deacetylation (GO:0090311) | 2.44089274 |
| 131 | regulation of clathrin-mediated endocytosis (GO:2000369) | 2.44087912 |
| 132 | regulation of Rap GTPase activity (GO:0032317) | 2.43638500 |
| 133 | positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145) | 2.43051319 |
| 134 | cellular response to epidermal growth factor stimulus (GO:0071364) | 2.42283838 |
| 135 | dosage compensation (GO:0007549) | 2.40965825 |
| 136 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213) | 2.40849915 |
| 137 | regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211) | 2.40849915 |
| 138 | regulation of histone methylation (GO:0031060) | 2.40477036 |
| 139 | adherens junction assembly (GO:0034333) | 2.40236737 |
| 140 | internal peptidyl-lysine acetylation (GO:0018393) | 2.39556225 |
| 141 | negative regulation of histone modification (GO:0031057) | 2.39199941 |
| 142 | chromatin assembly (GO:0031497) | 2.39106642 |
| 143 | regulation of RNA export from nucleus (GO:0046831) | 2.38680368 |
| 144 | thymic T cell selection (GO:0045061) | 2.38402340 |
| 145 | negative regulation of RNA splicing (GO:0033119) | 2.37632225 |
| 146 | histone acetylation (GO:0016573) | 2.37360655 |
| 147 | histone H2A monoubiquitination (GO:0035518) | 2.37270626 |
| 148 | regulation of gene expression by genetic imprinting (GO:0006349) | 2.37034161 |
| 149 | histone H3-K9 modification (GO:0061647) | 2.36853828 |
| 150 | mammary gland epithelial cell differentiation (GO:0060644) | 2.36751240 |
| 151 | semaphorin-plexin signaling pathway (GO:0071526) | 2.36709848 |
| 152 | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | 2.36049096 |
| 153 | positive regulation of DNA-dependent DNA replication (GO:2000105) | 2.35975980 |
| 154 | mitotic sister chromatid segregation (GO:0000070) | 2.35583472 |
| 155 | neural tube development (GO:0021915) | 2.34266735 |
| 156 | histone deubiquitination (GO:0016578) | 2.34168957 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MYC_22102868_ChIP-Seq_BL_Human | 4.51979077 |
| 2 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.17594132 |
| 3 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 3.17013004 |
| 4 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 3.16068090 |
| 5 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.14362156 |
| 6 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.13845080 |
| 7 | KDM2B_26808549_Chip-Seq_DND41_Human | 3.11133957 |
| 8 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.99607823 |
| 9 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.92784855 |
| 10 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.91514397 |
| 11 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 2.90765516 |
| 12 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.86281910 |
| 13 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 2.85686708 |
| 14 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 2.84759228 |
| 15 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 2.69564699 |
| 16 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 2.46046864 |
| 17 | * SCL_19346495_ChIP-Seq_HPC-7_Human | 2.41524739 |
| 18 | KDM2B_26808549_Chip-Seq_K562_Human | 2.39539338 |
| 19 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.31265892 |
| 20 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 2.30498483 |
| 21 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 2.22701610 |
| 22 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 2.12667009 |
| 23 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 2.10109150 |
| 24 | * TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 2.09263942 |
| 25 | UTX_26944678_Chip-Seq_JUKART_Human | 2.06894496 |
| 26 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 2.02823454 |
| 27 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.94230868 |
| 28 | GATA1_19941826_ChIP-Seq_K562_Human | 1.91674382 |
| 29 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.87904396 |
| 30 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.84873001 |
| 31 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.84095072 |
| 32 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.83401189 |
| 33 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.81840308 |
| 34 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.77813010 |
| 35 | * GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.76000918 |
| 36 | MAF_26560356_Chip-Seq_TH1_Human | 1.74907879 |
| 37 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.74451910 |
| 38 | * SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.72554904 |
| 39 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.68149613 |
| 40 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.67889369 |
| 41 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.66192804 |
| 42 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.61920052 |
| 43 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.61808275 |
| 44 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.61638548 |
| 45 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.58642463 |
| 46 | * EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.58633141 |
| 47 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.55979314 |
| 48 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.55575203 |
| 49 | NCOR1_26117541_ChIP-Seq_K562_Human | 1.53889105 |
| 50 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.52120312 |
| 51 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.52120123 |
| 52 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.51973374 |
| 53 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.51767650 |
| 54 | * WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.50468311 |
| 55 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.49424867 |
| 56 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.48614416 |
| 57 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.48427824 |
| 58 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.48427595 |
| 59 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.47594077 |
| 60 | SPI1_23127762_ChIP-Seq_K562_Human | 1.46442349 |
| 61 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.43477439 |
| 62 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.41343637 |
| 63 | * FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.41160447 |
| 64 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.40922186 |
| 65 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.39611125 |
| 66 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.39023193 |
| 67 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.36410168 |
| 68 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.36090981 |
| 69 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.35035073 |
| 70 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 1.34277158 |
| 71 | P68_20966046_ChIP-Seq_HELA_Human | 1.28773479 |
| 72 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.27271575 |
| 73 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 1.27120149 |
| 74 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.26281414 |
| 75 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.23211429 |
| 76 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.23011105 |
| 77 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.22738173 |
| 78 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.22721145 |
| 79 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.22470158 |
| 80 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.21635391 |
| 81 | MYB_26560356_Chip-Seq_TH1_Human | 1.20279089 |
| 82 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.20233335 |
| 83 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.20227784 |
| 84 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 1.20100815 |
| 85 | GATA1_22025678_ChIP-Seq_K562_Human | 1.19452246 |
| 86 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.17930798 |
| 87 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.17652761 |
| 88 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.17399900 |
| 89 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.16544310 |
| 90 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.15411479 |
| 91 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.15038168 |
| 92 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.14964448 |
| 93 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.13879735 |
| 94 | * MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.13874754 |
| 95 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.13493461 |
| 96 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 1.13341018 |
| 97 | * SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.12760512 |
| 98 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.12668585 |
| 99 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 1.11365563 |
| 100 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.10442548 |
| 101 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.10382958 |
| 102 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.08539569 |
| 103 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.08500483 |
| 104 | GATA2_19941826_ChIP-Seq_K562_Human | 1.07855088 |
| 105 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.07623578 |
| 106 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.06109166 |
| 107 | * RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.05919637 |
| 108 | MAF_26560356_Chip-Seq_TH2_Human | 1.05735027 |
| 109 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.05268754 |
| 110 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.04506125 |
| 111 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.03940833 |
| 112 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.03848076 |
| 113 | * GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.03145419 |
| 114 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.03006744 |
| 115 | MYB_26560356_Chip-Seq_TH2_Human | 1.02454205 |
| 116 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.01238922 |
| 117 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.01002613 |
| 118 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.00508565 |
| 119 | CHD1_26751641_Chip-Seq_LNCaP_Human | 1.00242028 |
| 120 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.99770709 |
| 121 | CLOCK_20551151_ChIP-Seq_293T_Human | 0.98918334 |
| 122 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.98624375 |
| 123 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.97758605 |
| 124 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.97602918 |
| 125 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.96663235 |
| 126 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.96095106 |
| 127 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.95734777 |
| 128 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.95687375 |
| 129 | ATF3_27146783_Chip-Seq_COLON_Human | 0.94661013 |
| 130 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 0.93892907 |
| 131 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.93743277 |
| 132 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.93729315 |
| 133 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.92344102 |
| 134 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.92155787 |
| 135 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 0.92140153 |
| 136 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.91148642 |
| 137 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.89782974 |
| 138 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.89750262 |
| 139 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.89114404 |
| 140 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.89097421 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005076_abnormal_cell_differentiation | 3.50531982 |
| 2 | MP0008961_abnormal_basal_metabolism | 3.37881349 |
| 3 | MP0002877_abnormal_melanocyte_morpholog | 3.02111444 |
| 4 | MP0003123_paternal_imprinting | 2.95075483 |
| 5 | MP0009278_abnormal_bone_marrow | 2.71327822 |
| 6 | MP0003283_abnormal_digestive_organ | 2.66488785 |
| 7 | MP0008995_early_reproductive_senescence | 2.59877648 |
| 8 | MP0002249_abnormal_larynx_morphology | 2.54786478 |
| 9 | MP0003300_gastrointestinal_ulcer | 2.50872055 |
| 10 | MP0010352_gastrointestinal_tract_polyps | 2.27440969 |
| 11 | MP0002909_abnormal_adrenal_gland | 2.25727299 |
| 12 | MP0008057_abnormal_DNA_replication | 2.25666138 |
| 13 | MP0004859_abnormal_synaptic_plasticity | 2.25086191 |
| 14 | MP0009780_abnormal_chondrocyte_physiolo | 2.24247129 |
| 15 | MP0005409_darkened_coat_color | 2.21766306 |
| 16 | MP0002653_abnormal_ependyma_morphology | 2.20233240 |
| 17 | MP0003787_abnormal_imprinting | 2.19830932 |
| 18 | MP0006072_abnormal_retinal_apoptosis | 2.11529812 |
| 19 | MP0003705_abnormal_hypodermis_morpholog | 2.06798326 |
| 20 | MP0004808_abnormal_hematopoietic_stem | 2.03472951 |
| 21 | MP0002822_catalepsy | 1.93814589 |
| 22 | MP0002009_preneoplasia | 1.83649747 |
| 23 | MP0001849_ear_inflammation | 1.80983116 |
| 24 | MP0003942_abnormal_urinary_system | 1.74891679 |
| 25 | MP0002796_impaired_skin_barrier | 1.72159277 |
| 26 | MP0010307_abnormal_tumor_latency | 1.70929624 |
| 27 | MP0000566_synostosis | 1.70617191 |
| 28 | MP0004264_abnormal_extraembryonic_tissu | 1.65844821 |
| 29 | MP0002098_abnormal_vibrissa_morphology | 1.65806394 |
| 30 | MP0005666_abnormal_adipose_tissue | 1.62085384 |
| 31 | MP0000703_abnormal_thymus_morphology | 1.59967911 |
| 32 | MP0001944_abnormal_pancreas_morphology | 1.58870182 |
| 33 | MP0003303_peritoneal_inflammation | 1.57880392 |
| 34 | MP0001545_abnormal_hematopoietic_system | 1.56106189 |
| 35 | MP0005397_hematopoietic_system_phenotyp | 1.56106189 |
| 36 | MP0005083_abnormal_biliary_tract | 1.50194882 |
| 37 | MP0002396_abnormal_hematopoietic_system | 1.47852372 |
| 38 | MP0000003_abnormal_adipose_tissue | 1.46982999 |
| 39 | MP0002693_abnormal_pancreas_physiology | 1.46043804 |
| 40 | MP0003693_abnormal_embryo_hatching | 1.45527110 |
| 41 | MP0003111_abnormal_nucleus_morphology | 1.40277855 |
| 42 | MP0005310_abnormal_salivary_gland | 1.40181875 |
| 43 | MP0005187_abnormal_penis_morphology | 1.39206823 |
| 44 | MP0002234_abnormal_pharynx_morphology | 1.38821443 |
| 45 | MP0004381_abnormal_hair_follicle | 1.36358332 |
| 46 | MP0003045_fibrosis | 1.35762993 |
| 47 | MP0003866_abnormal_defecation | 1.30435716 |
| 48 | MP0005551_abnormal_eye_electrophysiolog | 1.30300546 |
| 49 | MP0004782_abnormal_surfactant_physiolog | 1.25239401 |
| 50 | MP0000678_abnormal_parathyroid_gland | 1.24812555 |
| 51 | MP0002084_abnormal_developmental_patter | 1.24213069 |
| 52 | MP0010234_abnormal_vibrissa_follicle | 1.23400665 |
| 53 | MP0000733_abnormal_muscle_development | 1.23164113 |
| 54 | MP0000383_abnormal_hair_follicle | 1.22450308 |
| 55 | MP0004197_abnormal_fetal_growth/weight/ | 1.21198966 |
| 56 | MP0004185_abnormal_adipocyte_glucose | 1.21144446 |
| 57 | MP0004233_abnormal_muscle_weight | 1.20313837 |
| 58 | MP0000569_abnormal_digit_pigmentation | 1.20213538 |
| 59 | MP0008770_decreased_survivor_rate | 1.19494012 |
| 60 | MP0001730_embryonic_growth_arrest | 1.19213763 |
| 61 | MP0003119_abnormal_digestive_system | 1.17792985 |
| 62 | MP0009672_abnormal_birth_weight | 1.17002885 |
| 63 | MP0003763_abnormal_thymus_physiology | 1.16741318 |
| 64 | MP0003122_maternal_imprinting | 1.16450343 |
| 65 | MP0002086_abnormal_extraembryonic_tissu | 1.16411845 |
| 66 | MP0002398_abnormal_bone_marrow | 1.16133491 |
| 67 | MP0000350_abnormal_cell_proliferation | 1.13942934 |
| 68 | MP0000377_abnormal_hair_follicle | 1.12963787 |
| 69 | MP0000681_abnormal_thyroid_gland | 1.12312158 |
| 70 | MP0002925_abnormal_cardiovascular_devel | 1.11680434 |
| 71 | MP0005501_abnormal_skin_physiology | 1.11269172 |
| 72 | MP0010678_abnormal_skin_adnexa | 1.08688871 |
| 73 | MP0005670_abnormal_white_adipose | 1.07867511 |
| 74 | MP0004145_abnormal_muscle_electrophysio | 1.07380021 |
| 75 | MP0005646_abnormal_pituitary_gland | 1.06880020 |
| 76 | MP0005253_abnormal_eye_physiology | 1.06630177 |
| 77 | MP0002085_abnormal_embryonic_tissue | 1.05734729 |
| 78 | MP0003984_embryonic_growth_retardation | 1.05596038 |
| 79 | MP0001188_hyperpigmentation | 1.05363405 |
| 80 | MP0005375_adipose_tissue_phenotype | 1.05103696 |
| 81 | MP0009703_decreased_birth_body | 1.04784177 |
| 82 | MP0000537_abnormal_urethra_morphology | 1.04655464 |
| 83 | MP0002088_abnormal_embryonic_growth/wei | 1.03047337 |
| 84 | MP0001672_abnormal_embryogenesis/_devel | 1.02875503 |
| 85 | MP0005380_embryogenesis_phenotype | 1.02875503 |
| 86 | MP0004885_abnormal_endolymph | 1.01607497 |
| 87 | MP0000462_abnormal_digestive_system | 1.01605785 |
| 88 | MP0006292_abnormal_olfactory_placode | 1.01097732 |
| 89 | MP0001697_abnormal_embryo_size | 1.00644842 |
| 90 | MP0008569_lethality_at_weaning | 1.00516643 |
| 91 | MP0010630_abnormal_cardiac_muscle | 0.99701381 |
| 92 | MP0004957_abnormal_blastocyst_morpholog | 0.99656437 |
| 93 | MP0003121_genomic_imprinting | 0.99542105 |
| 94 | MP0000534_abnormal_ureter_morphology | 0.99232520 |
| 95 | MP0005220_abnormal_exocrine_pancreas | 0.99152895 |
| 96 | MP0002928_abnormal_bile_duct | 0.98683754 |
| 97 | MP0010094_abnormal_chromosome_stability | 0.97995729 |
| 98 | MP0003183_abnormal_peptide_metabolism | 0.96726310 |
| 99 | MP0001881_abnormal_mammary_gland | 0.96421438 |
| 100 | MP0004858_abnormal_nervous_system | 0.96000405 |
| 101 | MP0005499_abnormal_olfactory_system | 0.95707085 |
| 102 | MP0005394_taste/olfaction_phenotype | 0.95707085 |
| 103 | MP0003077_abnormal_cell_cycle | 0.95302064 |
| 104 | MP0002080_prenatal_lethality | 0.95235522 |
| 105 | MP0003172_abnormal_lysosome_physiology | 0.95194965 |
| 106 | MP0001784_abnormal_fluid_regulation | 0.94114479 |
| 107 | MP0005451_abnormal_body_composition | 0.94018423 |
| 108 | MP0000627_abnormal_mammary_gland | 0.93860540 |
| 109 | MP0004510_myositis | 0.93611988 |
| 110 | MP0002166_altered_tumor_susceptibility | 0.93106864 |
| 111 | MP0002751_abnormal_autonomic_nervous | 0.92343832 |
| 112 | MP0003566_abnormal_cell_adhesion | 0.92186784 |
| 113 | MP0002089_abnormal_postnatal_growth/wei | 0.91378220 |
| 114 | MP0003861_abnormal_nervous_system | 0.91108871 |
| 115 | MP0004811_abnormal_neuron_physiology | 0.90814208 |
| 116 | MP0000266_abnormal_heart_morphology | 0.90367043 |
| 117 | MP0000490_abnormal_crypts_of | 0.90237478 |
| 118 | MP0002116_abnormal_craniofacial_bone | 0.90191340 |
| 119 | MP0001727_abnormal_embryo_implantation | 0.90168612 |
| 120 | MP0001346_abnormal_lacrimal_gland | 0.89897185 |
| 121 | MP0002722_abnormal_immune_system | 0.88138833 |
| 122 | MP0006138_congestive_heart_failure | 0.87568743 |
| 123 | MP0009115_abnormal_fat_cell | 0.87463719 |
| 124 | MP0002184_abnormal_innervation | 0.86997475 |
| 125 | MP0003948_abnormal_gas_homeostasis | 0.86836477 |
| 126 | MP0009931_abnormal_skin_appearance | 0.86262256 |
| 127 | MP0004270_analgesia | 0.84247138 |
| 128 | MP0001502_abnormal_circadian_rhythm | 0.83074839 |
| 129 | MP0003115_abnormal_respiratory_system | 0.82632383 |
| 130 | MP0000631_abnormal_neuroendocrine_gland | 0.82357127 |
| 131 | MP0003890_abnormal_embryonic-extraembry | 0.81880344 |
| 132 | MP0005391_vision/eye_phenotype | 0.81364897 |
| 133 | MP0003936_abnormal_reproductive_system | 0.80268347 |
| 134 | MP0002078_abnormal_glucose_homeostasis | 0.79606559 |
| 135 | MP0003656_abnormal_erythrocyte_physiolo | 0.78579381 |
| 136 | MP0003935_abnormal_craniofacial_develop | 0.78066978 |
| 137 | MP0000428_abnormal_craniofacial_morphol | 0.77992520 |
| 138 | MP0003635_abnormal_synaptic_transmissio | 0.77406974 |
| 139 | MP0002970_abnormal_white_adipose | 0.77181945 |
| 140 | MP0004947_skin_inflammation | 0.76412417 |
| 141 | MP0001919_abnormal_reproductive_system | 0.75963819 |
| 142 | MP0002081_perinatal_lethality | 0.75631449 |
| 143 | MP0001348_abnormal_lacrimal_gland | 0.75618749 |
| 144 | MP0001661_extended_life_span | 0.75473117 |
| 145 | MP0000427_abnormal_hair_cycle | 0.75392011 |
| 146 | MP0003943_abnormal_hepatobiliary_system | 0.74784411 |
| 147 | MP0008877_abnormal_DNA_methylation | 0.73820822 |
| 148 | MP0003699_abnormal_female_reproductive | 0.72945353 |
| 149 | MP0003959_abnormal_lean_body | 0.72865258 |
| 150 | MP0001915_intracranial_hemorrhage | 0.71944503 |
| 151 | MP0002152_abnormal_brain_morphology | 0.70506520 |
| 152 | MP0002160_abnormal_reproductive_system | 0.69854662 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of the fingertips (HP:0001211) | 4.45459388 |
| 2 | Hyperacusis (HP:0010780) | 4.14354148 |
| 3 | Asymmetry of the thorax (HP:0001555) | 3.69409847 |
| 4 | Septate vagina (HP:0001153) | 3.67084349 |
| 5 | Germ cell neoplasia (HP:0100728) | 3.61502982 |
| 6 | Macroorchidism (HP:0000053) | 3.48558298 |
| 7 | Insomnia (HP:0100785) | 3.44045140 |
| 8 | Sparse lateral eyebrow (HP:0005338) | 3.21423779 |
| 9 | Elfin facies (HP:0004428) | 2.97064072 |
| 10 | Hyperthyroidism (HP:0000836) | 2.90429853 |
| 11 | Bony spicule pigmentary retinopathy (HP:0007737) | 2.86976012 |
| 12 | Volvulus (HP:0002580) | 2.81191430 |
| 13 | Curly hair (HP:0002212) | 2.79233912 |
| 14 | Neoplasm of the heart (HP:0100544) | 2.76101075 |
| 15 | Long eyelashes (HP:0000527) | 2.71047625 |
| 16 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.69349461 |
| 17 | Chromsome breakage (HP:0040012) | 2.68004898 |
| 18 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.67540087 |
| 19 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.57203877 |
| 20 | Testicular neoplasm (HP:0010788) | 2.56684090 |
| 21 | Congenital stationary night blindness (HP:0007642) | 2.54337018 |
| 22 | Renovascular hypertension (HP:0100817) | 2.52616864 |
| 23 | Patellar dislocation (HP:0002999) | 2.48045102 |
| 24 | Obstructive sleep apnea (HP:0002870) | 2.45487373 |
| 25 | Flat acetabular roof (HP:0003180) | 2.44274691 |
| 26 | Abnormality of the aortic arch (HP:0012303) | 2.43987357 |
| 27 | Obsessive-compulsive behavior (HP:0000722) | 2.43541595 |
| 28 | Neonatal hypoglycemia (HP:0001998) | 2.42770824 |
| 29 | Heterotopia (HP:0002282) | 2.39773565 |
| 30 | Truncus arteriosus (HP:0001660) | 2.38882509 |
| 31 | Vertebral arch anomaly (HP:0008438) | 2.38698802 |
| 32 | Pendular nystagmus (HP:0012043) | 2.34567345 |
| 33 | Cerebral aneurysm (HP:0004944) | 2.34147955 |
| 34 | Short 4th metacarpal (HP:0010044) | 2.31943283 |
| 35 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.31943283 |
| 36 | Abnormality of the lower motor neuron (HP:0002366) | 2.31937627 |
| 37 | Thin bony cortex (HP:0002753) | 2.31419198 |
| 38 | Hypoparathyroidism (HP:0000829) | 2.30121782 |
| 39 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.29220070 |
| 40 | Overriding aorta (HP:0002623) | 2.28983806 |
| 41 | Ependymoma (HP:0002888) | 2.28919536 |
| 42 | Increased nuchal translucency (HP:0010880) | 2.27515783 |
| 43 | Renal duplication (HP:0000075) | 2.27188931 |
| 44 | Pointed chin (HP:0000307) | 2.25793918 |
| 45 | J-shaped sella turcica (HP:0002680) | 2.25019174 |
| 46 | Truncal obesity (HP:0001956) | 2.22401480 |
| 47 | Neoplasm of the oral cavity (HP:0100649) | 2.20927929 |
| 48 | Broad face (HP:0000283) | 2.20493520 |
| 49 | Abnormality of endocrine pancreas physiology (HP:0012093) | 2.18109815 |
| 50 | Abnormality of the pancreatic islet cells (HP:0006476) | 2.18109815 |
| 51 | Dysmetric saccades (HP:0000641) | 2.17002619 |
| 52 | Broad palm (HP:0001169) | 2.16840047 |
| 53 | Urethral obstruction (HP:0000796) | 2.15183344 |
| 54 | Astrocytoma (HP:0009592) | 2.15044008 |
| 55 | Abnormality of the astrocytes (HP:0100707) | 2.15044008 |
| 56 | Posterior subcapsular cataract (HP:0007787) | 2.14557951 |
| 57 | Acute lymphatic leukemia (HP:0006721) | 2.13526930 |
| 58 | Acute myeloid leukemia (HP:0004808) | 2.12052788 |
| 59 | Abnormality of the phalanges of the hallux (HP:0010057) | 2.11753346 |
| 60 | Bowel incontinence (HP:0002607) | 2.10168512 |
| 61 | Trigonocephaly (HP:0000243) | 2.09466459 |
| 62 | Central scotoma (HP:0000603) | 2.09453573 |
| 63 | Hypercortisolism (HP:0001578) | 2.07620230 |
| 64 | Prominent nose (HP:0000448) | 2.07012298 |
| 65 | Poikilocytosis (HP:0004447) | 2.04543017 |
| 66 | Type II diabetes mellitus (HP:0005978) | 2.03034736 |
| 67 | Deep philtrum (HP:0002002) | 2.02702923 |
| 68 | Abnormality of the parathyroid morphology (HP:0011766) | 2.01299967 |
| 69 | Homocystinuria (HP:0002156) | 2.00225669 |
| 70 | Abnormality of homocysteine metabolism (HP:0010919) | 2.00225669 |
| 71 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.99835560 |
| 72 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.99563423 |
| 73 | Enlarged penis (HP:0000040) | 1.98827560 |
| 74 | Genetic anticipation (HP:0003743) | 1.97069990 |
| 75 | Self-mutilation (HP:0000742) | 1.95603928 |
| 76 | Narrow palate (HP:0000189) | 1.92987233 |
| 77 | Overlapping toe (HP:0001845) | 1.92888100 |
| 78 | Abnormality of reticulocytes (HP:0004312) | 1.92526152 |
| 79 | Sandal gap (HP:0001852) | 1.92470986 |
| 80 | High anterior hairline (HP:0009890) | 1.92417425 |
| 81 | Anal stenosis (HP:0002025) | 1.92287738 |
| 82 | Patellar aplasia (HP:0006443) | 1.91550567 |
| 83 | Bowel diverticulosis (HP:0005222) | 1.91063639 |
| 84 | Basal cell carcinoma (HP:0002671) | 1.90776929 |
| 85 | Advanced eruption of teeth (HP:0006288) | 1.90527131 |
| 86 | Panhypogammaglobulinemia (HP:0003139) | 1.90240196 |
| 87 | Hepatoblastoma (HP:0002884) | 1.90056986 |
| 88 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.88490659 |
| 89 | Thick eyebrow (HP:0000574) | 1.88158294 |
| 90 | Lip pit (HP:0100267) | 1.87774389 |
| 91 | Colitis (HP:0002583) | 1.86909058 |
| 92 | Thyroiditis (HP:0100646) | 1.86411471 |
| 93 | Impulsivity (HP:0100710) | 1.86102656 |
| 94 | Lymphangioma (HP:0100764) | 1.84896274 |
| 95 | Deep palmar crease (HP:0006191) | 1.84620738 |
| 96 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.84256125 |
| 97 | Abnormal large intestine physiology (HP:0012700) | 1.82954493 |
| 98 | Flat cornea (HP:0007720) | 1.82885642 |
| 99 | Papilloma (HP:0012740) | 1.79784222 |
| 100 | Verrucae (HP:0200043) | 1.79784222 |
| 101 | Cafe-au-lait spot (HP:0000957) | 1.79437438 |
| 102 | Disproportionate tall stature (HP:0001519) | 1.79411931 |
| 103 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.78947073 |
| 104 | Abnormality of chromosome segregation (HP:0002916) | 1.78925769 |
| 105 | Impaired smooth pursuit (HP:0007772) | 1.78632841 |
| 106 | Recurrent viral infections (HP:0004429) | 1.77806916 |
| 107 | Concave nail (HP:0001598) | 1.77528814 |
| 108 | Reticulocytosis (HP:0001923) | 1.76956957 |
| 109 | Papillary thyroid carcinoma (HP:0002895) | 1.76768200 |
| 110 | Abnormality of the diencephalon (HP:0010662) | 1.76643132 |
| 111 | Skin tags (HP:0010609) | 1.76462538 |
| 112 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.76369441 |
| 113 | Polycystic kidney dysplasia (HP:0000113) | 1.76361700 |
| 114 | Abnormality of the columella (HP:0009929) | 1.76088016 |
| 115 | Scotoma (HP:0000575) | 1.75815324 |
| 116 | Spina bifida occulta (HP:0003298) | 1.73904397 |
| 117 | Abnormal gallbladder physiology (HP:0012438) | 1.73569557 |
| 118 | Cholecystitis (HP:0001082) | 1.73569557 |
| 119 | Facial hemangioma (HP:0000329) | 1.73460518 |
| 120 | Embryonal neoplasm (HP:0002898) | 1.73356606 |
| 121 | Gastrointestinal inflammation (HP:0004386) | 1.72461337 |
| 122 | High pitched voice (HP:0001620) | 1.72106844 |
| 123 | Relative macrocephaly (HP:0004482) | 1.71643891 |
| 124 | Ankyloglossia (HP:0010296) | 1.70681853 |
| 125 | Smooth philtrum (HP:0000319) | 1.70389595 |
| 126 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.70246509 |
| 127 | Increased density of long bones (HP:0006392) | 1.69857632 |
| 128 | Mask-like facies (HP:0000298) | 1.69714171 |
| 129 | Open mouth (HP:0000194) | 1.69076924 |
| 130 | Abnormality of the gastric mucosa (HP:0004295) | 1.68743224 |
| 131 | Pseudobulbar signs (HP:0002200) | 1.68195051 |
| 132 | Shawl scrotum (HP:0000049) | 1.68075998 |
| 133 | Atelectasis (HP:0100750) | 1.67453022 |
| 134 | Metaphyseal cupping (HP:0003021) | 1.66751337 |
| 135 | Attention deficit hyperactivity disorder (HP:0007018) | 1.66345177 |
| 136 | Short phalanx of the thumb (HP:0009660) | 1.66343921 |
| 137 | Hand muscle atrophy (HP:0009130) | 1.65348117 |
| 138 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.65253006 |
| 139 | Long palpebral fissure (HP:0000637) | 1.64872668 |
| 140 | T lymphocytopenia (HP:0005403) | 1.64100010 |
| 141 | Gastrointestinal carcinoma (HP:0002672) | 1.63890678 |
| 142 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.63890678 |
| 143 | Embryonal renal neoplasm (HP:0011794) | 1.63498603 |
| 144 | Precocious puberty (HP:0000826) | 1.63231012 |
| 145 | Depressed nasal tip (HP:0000437) | 1.63088347 |
| 146 | Supernumerary ribs (HP:0005815) | 1.62790446 |
| 147 | Upper limb amyotrophy (HP:0009129) | 1.62616722 |
| 148 | Distal upper limb amyotrophy (HP:0007149) | 1.62616722 |
| 149 | Cellulitis (HP:0100658) | 1.62340933 |
| 150 | Sporadic (HP:0003745) | 1.62329238 |
| 151 | Sacral dimple (HP:0000960) | 1.62061989 |
| 152 | Deformed sella turcica (HP:0002681) | 1.61690734 |
| 153 | Uterine leiomyosarcoma (HP:0002891) | 1.59909513 |
| 154 | Leiomyosarcoma (HP:0100243) | 1.59909513 |
| 155 | Broad thumb (HP:0011304) | 1.59468157 |
| 156 | Large for gestational age (HP:0001520) | 1.59076097 |
| 157 | Seborrheic dermatitis (HP:0001051) | 1.58954845 |
| 158 | Aneurysm (HP:0002617) | 1.58674926 |
| 159 | Cutis marmorata (HP:0000965) | 1.58415621 |
| 160 | Radioulnar synostosis (HP:0002974) | 1.57686144 |
| 161 | Diastasis recti (HP:0001540) | 1.57588037 |
| 162 | EMG: neuropathic changes (HP:0003445) | 1.56868711 |
| 163 | Chin dimple (HP:0010751) | 1.56450639 |
| 164 | Proximal placement of thumb (HP:0009623) | 1.56308113 |
| 165 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.56295367 |
| 166 | Tented upper lip vermilion (HP:0010804) | 1.55299716 |
| 167 | Bicornuate uterus (HP:0000813) | 1.55090049 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP3K10 | 4.93294369 |
| 2 | CDK12 | 4.39215933 |
| 3 | EEF2K | 3.95025129 |
| 4 | TRIB3 | 3.16731469 |
| 5 | SMG1 | 2.70839642 |
| 6 | SIK2 | 2.63357648 |
| 7 | PKN2 | 2.54032399 |
| 8 | BRD4 | 2.26799699 |
| 9 | TAOK3 | 2.26227524 |
| 10 | ICK | 2.09859606 |
| 11 | HIPK2 | 1.81944805 |
| 12 | CAMK1G | 1.81488100 |
| 13 | SIK1 | 1.75858995 |
| 14 | RIPK1 | 1.73617368 |
| 15 | ERN1 | 1.70981469 |
| 16 | TAOK1 | 1.65829403 |
| 17 | MAPKAPK3 | 1.58672303 |
| 18 | MAP4K1 | 1.56439118 |
| 19 | AKT3 | 1.56102131 |
| 20 | NEK2 | 1.55040303 |
| 21 | PRKD3 | 1.52428672 |
| 22 | CAMK1D | 1.50924946 |
| 23 | PRPF4B | 1.50661399 |
| 24 | PTK6 | 1.47131187 |
| 25 | ALK | 1.46636605 |
| 26 | MARK2 | 1.38748909 |
| 27 | MAP3K7 | 1.38287096 |
| 28 | MTOR | 1.37428851 |
| 29 | CDK7 | 1.35580937 |
| 30 | PASK | 1.30814845 |
| 31 | EIF2AK1 | 1.29353636 |
| 32 | GRK6 | 1.28765937 |
| 33 | PRKD2 | 1.23628117 |
| 34 | EPHA2 | 1.19476550 |
| 35 | MAP2K2 | 1.17113692 |
| 36 | SCYL2 | 1.12138609 |
| 37 | CDC42BPA | 1.11773663 |
| 38 | INSRR | 1.10914507 |
| 39 | PDGFRA | 1.08697681 |
| 40 | DMPK | 1.02640616 |
| 41 | PRKCH | 1.02008223 |
| 42 | CDK6 | 1.01204857 |
| 43 | DYRK1B | 1.00631689 |
| 44 | UHMK1 | 0.96611929 |
| 45 | CDK9 | 0.92470304 |
| 46 | CDC7 | 0.92086435 |
| 47 | RPS6KB2 | 0.91789414 |
| 48 | CDK4 | 0.90615543 |
| 49 | RET | 0.88477788 |
| 50 | TYRO3 | 0.88295074 |
| 51 | SGK3 | 0.87520954 |
| 52 | RPS6KA2 | 0.85217512 |
| 53 | TTK | 0.84591478 |
| 54 | MAP3K9 | 0.83720477 |
| 55 | PDGFRB | 0.80372672 |
| 56 | FGFR3 | 0.79424467 |
| 57 | SGK2 | 0.77512213 |
| 58 | STK11 | 0.76591598 |
| 59 | FGFR2 | 0.75562889 |
| 60 | STK10 | 0.73049537 |
| 61 | CHEK2 | 0.71627425 |
| 62 | MARK1 | 0.69230022 |
| 63 | NEK6 | 0.68960624 |
| 64 | CAMKK1 | 0.67808759 |
| 65 | BMX | 0.66025706 |
| 66 | MAP3K1 | 0.63795243 |
| 67 | WNK1 | 0.63762650 |
| 68 | MAP2K1 | 0.63431294 |
| 69 | RPS6KB1 | 0.62704412 |
| 70 | MAPK11 | 0.62158705 |
| 71 | NTRK3 | 0.61716992 |
| 72 | PNCK | 0.61384500 |
| 73 | PTK2 | 0.60363721 |
| 74 | CHUK | 0.59925638 |
| 75 | PRKAA1 | 0.59438675 |
| 76 | STK4 | 0.59258814 |
| 77 | MAPK14 | 0.57947757 |
| 78 | KSR1 | 0.57870554 |
| 79 | CDK2 | 0.57701972 |
| 80 | CAMK4 | 0.57117194 |
| 81 | CHEK1 | 0.56482738 |
| 82 | PAK6 | 0.55100142 |
| 83 | ERBB2 | 0.54852012 |
| 84 | PRKD1 | 0.54054598 |
| 85 | NME1 | 0.53760151 |
| 86 | KSR2 | 0.53697723 |
| 87 | MAP3K6 | 0.53462872 |
| 88 | CSNK1E | 0.53130878 |
| 89 | NEK1 | 0.52758526 |
| 90 | MAP3K2 | 0.51909844 |
| 91 | LATS2 | 0.51835418 |
| 92 | GSK3B | 0.51329513 |
| 93 | SGK223 | 0.51226473 |
| 94 | SGK494 | 0.51226473 |
| 95 | FES | 0.50799829 |
| 96 | MUSK | 0.50735723 |
| 97 | JAK2 | 0.50058693 |
| 98 | NTRK2 | 0.49834388 |
| 99 | HCK | 0.48757043 |
| 100 | MAPK15 | 0.48749559 |
| 101 | LATS1 | 0.48333551 |
| 102 | RPS6KA1 | 0.47924845 |
| 103 | PRKDC | 0.47567191 |
| 104 | RPS6KC1 | 0.46743943 |
| 105 | RPS6KL1 | 0.46743943 |
| 106 | ILK | 0.46440639 |
| 107 | BTK | 0.46054118 |
| 108 | PIM1 | 0.45831798 |
| 109 | CDK3 | 0.45721885 |
| 110 | LRRK2 | 0.44369662 |
| 111 | ATM | 0.44278329 |
| 112 | MAPK10 | 0.43871967 |
| 113 | MAPK8 | 0.43372750 |
| 114 | ATR | 0.43202362 |
| 115 | MAPK9 | 0.42753758 |
| 116 | PAK2 | 0.42317590 |
| 117 | MAPK3 | 0.42162180 |
| 118 | PRKAA2 | 0.41979189 |
| 119 | MAPK1 | 0.41010901 |
| 120 | CLK1 | 0.40894866 |
| 121 | FGFR4 | 0.40521142 |
| 122 | PDPK1 | 0.40253051 |
| 123 | PIK3CA | 0.39529852 |
| 124 | SIK3 | 0.39333160 |
| 125 | STK38 | 0.39178959 |
| 126 | RPS6KA6 | 0.39044022 |
| 127 | RPS6KA3 | 0.37981621 |
| 128 | CDK1 | 0.37963256 |
| 129 | CSNK1D | 0.37933594 |
| 130 | AKT1 | 0.37080482 |
| 131 | TNK2 | 0.37016763 |
| 132 | SGK1 | 0.36441506 |
| 133 | SYK | 0.36033373 |
| 134 | PRKCI | 0.35597696 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 2.06731793 |
| 2 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.03742957 |
| 3 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.84460370 |
| 4 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.83948972 |
| 5 | Lysine degradation_Homo sapiens_hsa00310 | 1.81713957 |
| 6 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.78534312 |
| 7 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.63531395 |
| 8 | Phototransduction_Homo sapiens_hsa04744 | 1.60951984 |
| 9 | Insulin secretion_Homo sapiens_hsa04911 | 1.59587280 |
| 10 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.52586362 |
| 11 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.49454964 |
| 12 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.49419355 |
| 13 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.36446895 |
| 14 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.35502548 |
| 15 | Glioma_Homo sapiens_hsa05214 | 1.35283698 |
| 16 | Endometrial cancer_Homo sapiens_hsa05213 | 1.35132166 |
| 17 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.34997024 |
| 18 | Cell cycle_Homo sapiens_hsa04110 | 1.33286674 |
| 19 | Long-term potentiation_Homo sapiens_hsa04720 | 1.29738881 |
| 20 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.29454739 |
| 21 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.27917346 |
| 22 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.27782916 |
| 23 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.24337169 |
| 24 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.23046514 |
| 25 | Insulin resistance_Homo sapiens_hsa04931 | 1.19803446 |
| 26 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.19148822 |
| 27 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.18736778 |
| 28 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.17786750 |
| 29 | Colorectal cancer_Homo sapiens_hsa05210 | 1.16118287 |
| 30 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.13975657 |
| 31 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.12459886 |
| 32 | Olfactory transduction_Homo sapiens_hsa04740 | 1.10594766 |
| 33 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.09262151 |
| 34 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.08422847 |
| 35 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.08245569 |
| 36 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.07786127 |
| 37 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.07711967 |
| 38 | Circadian entrainment_Homo sapiens_hsa04713 | 1.06474328 |
| 39 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.05488625 |
| 40 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.05019645 |
| 41 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.04376426 |
| 42 | RNA transport_Homo sapiens_hsa03013 | 1.02599347 |
| 43 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.99803301 |
| 44 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.99030559 |
| 45 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.98345640 |
| 46 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.98294366 |
| 47 | DNA replication_Homo sapiens_hsa03030 | 0.97686723 |
| 48 | Base excision repair_Homo sapiens_hsa03410 | 0.96337927 |
| 49 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.96103195 |
| 50 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.96092018 |
| 51 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.95030308 |
| 52 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.94034148 |
| 53 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.93564532 |
| 54 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.91639803 |
| 55 | Cocaine addiction_Homo sapiens_hsa05030 | 0.91161354 |
| 56 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.91076768 |
| 57 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.89816901 |
| 58 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.88523609 |
| 59 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.88454142 |
| 60 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.87991003 |
| 61 | Platelet activation_Homo sapiens_hsa04611 | 0.87878353 |
| 62 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.87327980 |
| 63 | Adherens junction_Homo sapiens_hsa04520 | 0.87008911 |
| 64 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.86789673 |
| 65 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.86262173 |
| 66 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.85613914 |
| 67 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.85501927 |
| 68 | Circadian rhythm_Homo sapiens_hsa04710 | 0.85430148 |
| 69 | Melanoma_Homo sapiens_hsa05218 | 0.85346081 |
| 70 | Spliceosome_Homo sapiens_hsa03040 | 0.84302338 |
| 71 | Salivary secretion_Homo sapiens_hsa04970 | 0.83413150 |
| 72 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.83372908 |
| 73 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.83369843 |
| 74 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.83222171 |
| 75 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.81382446 |
| 76 | Bladder cancer_Homo sapiens_hsa05219 | 0.80701223 |
| 77 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.78258446 |
| 78 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.78238875 |
| 79 | HTLV-I infection_Homo sapiens_hsa05166 | 0.78135472 |
| 80 | ABC transporters_Homo sapiens_hsa02010 | 0.77627759 |
| 81 | Axon guidance_Homo sapiens_hsa04360 | 0.77382025 |
| 82 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.77044676 |
| 83 | Morphine addiction_Homo sapiens_hsa05032 | 0.75929686 |
| 84 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.75244220 |
| 85 | Prostate cancer_Homo sapiens_hsa05215 | 0.74939719 |
| 86 | Hepatitis B_Homo sapiens_hsa05161 | 0.73906180 |
| 87 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.73548326 |
| 88 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.73507424 |
| 89 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.73466737 |
| 90 | Long-term depression_Homo sapiens_hsa04730 | 0.73388902 |
| 91 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.73242470 |
| 92 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.72780777 |
| 93 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.72674873 |
| 94 | Gap junction_Homo sapiens_hsa04540 | 0.72540127 |
| 95 | Renin secretion_Homo sapiens_hsa04924 | 0.72417146 |
| 96 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.70909456 |
| 97 | Thyroid cancer_Homo sapiens_hsa05216 | 0.70506861 |
| 98 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.70412655 |
| 99 | Melanogenesis_Homo sapiens_hsa04916 | 0.69913668 |
| 100 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.69707640 |
| 101 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.69704686 |
| 102 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.68842357 |
| 103 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.68508513 |
| 104 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.68494474 |
| 105 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.67365038 |
| 106 | GABAergic synapse_Homo sapiens_hsa04727 | 0.66846108 |
| 107 | Alcoholism_Homo sapiens_hsa05034 | 0.66770379 |
| 108 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.64972180 |
| 109 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.64868241 |
| 110 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.64359967 |
| 111 | Tight junction_Homo sapiens_hsa04530 | 0.62886615 |
| 112 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.62645552 |
| 113 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.62197151 |
| 114 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.61946823 |
| 115 | Focal adhesion_Homo sapiens_hsa04510 | 0.61336069 |
| 116 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.61310281 |
| 117 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.60438406 |
| 118 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.60090293 |
| 119 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.59406369 |
| 120 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.58478646 |
| 121 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.58110781 |
| 122 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.56468523 |
| 123 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.55858328 |
| 124 | Hepatitis C_Homo sapiens_hsa05160 | 0.54193541 |
| 125 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.52156799 |
| 126 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.51563831 |
| 127 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.48745041 |
| 128 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.46693092 |
| 129 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.46340468 |
| 130 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.42660594 |
| 131 | Other glycan degradation_Homo sapiens_hsa00511 | 0.42117268 |

