

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.75644726 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.61887811 |
| 3 | daunorubicin metabolic process (GO:0044597) | 5.58551284 |
| 4 | polyketide metabolic process (GO:0030638) | 5.58551284 |
| 5 | doxorubicin metabolic process (GO:0044598) | 5.58551284 |
| 6 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 5.55826704 |
| 7 | vocalization behavior (GO:0071625) | 5.34342971 |
| 8 | locomotory exploration behavior (GO:0035641) | 5.06274242 |
| 9 | synaptic vesicle maturation (GO:0016188) | 4.91221322 |
| 10 | * regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.84492211 |
| 11 | regulation of synapse structural plasticity (GO:0051823) | 4.70851488 |
| 12 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.68638953 |
| 13 | * regulation of glutamate receptor signaling pathway (GO:1900449) | 4.52421605 |
| 14 | postsynaptic membrane organization (GO:0001941) | 4.47362595 |
| 15 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.46723101 |
| 16 | synaptic vesicle exocytosis (GO:0016079) | 4.45640910 |
| 17 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.34786200 |
| 18 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 4.30503207 |
| 19 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.28533436 |
| 20 | positive regulation of neurotransmitter secretion (GO:0001956) | 4.24814797 |
| 21 | righting reflex (GO:0060013) | 4.20741555 |
| 22 | synaptic transmission, glutamatergic (GO:0035249) | 4.19578013 |
| 23 | regulation of synaptic vesicle transport (GO:1902803) | 4.18594769 |
| 24 | synaptic vesicle endocytosis (GO:0048488) | 4.14224149 |
| 25 | positive regulation of neurotransmitter transport (GO:0051590) | 4.12537593 |
| 26 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.10770439 |
| 27 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.06238928 |
| 28 | glutamate receptor signaling pathway (GO:0007215) | 4.03263431 |
| 29 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.00798868 |
| 30 | protein localization to synapse (GO:0035418) | 3.98586262 |
| 31 | glutamate secretion (GO:0014047) | 3.97115740 |
| 32 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.95065972 |
| 33 | prepulse inhibition (GO:0060134) | 3.94283140 |
| 34 | neuron-neuron synaptic transmission (GO:0007270) | 3.93246174 |
| 35 | auditory behavior (GO:0031223) | 3.93042513 |
| 36 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.84674920 |
| 37 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.83737500 |
| 38 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.81369851 |
| 39 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 3.80588964 |
| 40 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.79772069 |
| 41 | response to auditory stimulus (GO:0010996) | 3.78053311 |
| 42 | dendritic spine morphogenesis (GO:0060997) | 3.74179441 |
| 43 | exploration behavior (GO:0035640) | 3.73534772 |
| 44 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.72723674 |
| 45 | neurotransmitter secretion (GO:0007269) | 3.71882169 |
| 46 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.71045143 |
| 47 | regulation of sarcomere organization (GO:0060297) | 3.70232784 |
| 48 | positive regulation of membrane potential (GO:0045838) | 3.65939516 |
| 49 | neuron cell-cell adhesion (GO:0007158) | 3.64234973 |
| 50 | regulation of postsynaptic membrane potential (GO:0060078) | 3.61758456 |
| 51 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.51311567 |
| 52 | glycine transport (GO:0015816) | 3.50406520 |
| 53 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.48605965 |
| 54 | aminoglycoside antibiotic metabolic process (GO:0030647) | 3.47406477 |
| 55 | response to misfolded protein (GO:0051788) | 3.46860253 |
| 56 | cell migration in hindbrain (GO:0021535) | 3.46351283 |
| 57 | cerebellar granule cell differentiation (GO:0021707) | 3.46236736 |
| 58 | long-term memory (GO:0007616) | 3.44992681 |
| 59 | membrane hyperpolarization (GO:0060081) | 3.42063585 |
| 60 | reflex (GO:0060004) | 3.41943581 |
| 61 | neuronal ion channel clustering (GO:0045161) | 3.40356113 |
| 62 | proline transport (GO:0015824) | 3.39715253 |
| 63 | chemosensory behavior (GO:0007635) | 3.39625076 |
| 64 | neuronal action potential propagation (GO:0019227) | 3.37498853 |
| 65 | serotonin metabolic process (GO:0042428) | 3.37351783 |
| 66 | regulation of synaptic plasticity (GO:0048167) | 3.37123665 |
| 67 | regulation of neurotransmitter secretion (GO:0046928) | 3.36744592 |
| 68 | neuromuscular synaptic transmission (GO:0007274) | 3.35913956 |
| 69 | negative regulation of adenylate cyclase activity (GO:0007194) | 3.35160750 |
| 70 | cellular potassium ion homeostasis (GO:0030007) | 3.33273922 |
| 71 | L-amino acid import (GO:0043092) | 3.30125525 |
| 72 | layer formation in cerebral cortex (GO:0021819) | 3.27115530 |
| 73 | regulation of neurotransmitter transport (GO:0051588) | 3.26644458 |
| 74 | membrane depolarization during action potential (GO:0086010) | 3.26240365 |
| 75 | striatum development (GO:0021756) | 3.25759298 |
| 76 | response to histamine (GO:0034776) | 3.25473543 |
| 77 | positive regulation of synapse maturation (GO:0090129) | 3.25391619 |
| 78 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 3.21881976 |
| 79 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 3.21881976 |
| 80 | regulation of translation, ncRNA-mediated (GO:0045974) | 3.21881976 |
| 81 | adult walking behavior (GO:0007628) | 3.20631991 |
| 82 | membrane depolarization (GO:0051899) | 3.19552669 |
| 83 | negative regulation of cyclase activity (GO:0031280) | 3.19458847 |
| 84 | transmission of nerve impulse (GO:0019226) | 3.16306900 |
| 85 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.15780676 |
| 86 | long-term synaptic potentiation (GO:0060291) | 3.15039113 |
| 87 | regulation of synaptic transmission, GABAergic (GO:0032228) | 3.12632239 |
| 88 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.10190569 |
| 89 | neuromuscular process controlling balance (GO:0050885) | 3.10116324 |
| 90 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.10051710 |
| 91 | dendritic spine organization (GO:0097061) | 3.09982974 |
| 92 | synaptic transmission, dopaminergic (GO:0001963) | 3.09757678 |
| 93 | regulation of synapse maturation (GO:0090128) | 3.09559800 |
| 94 | regulation of dendritic spine development (GO:0060998) | 3.09371925 |
| 95 | behavioral response to cocaine (GO:0048148) | 3.08990809 |
| 96 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.08430055 |
| 97 | positive regulation of CREB transcription factor activity (GO:0032793) | 3.06727857 |
| 98 | positive regulation of synaptic transmission (GO:0050806) | 3.05937603 |
| 99 | potassium ion transmembrane transport (GO:0071805) | 3.05662900 |
| 100 | cellular potassium ion transport (GO:0071804) | 3.05662900 |
| 101 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 3.05115381 |
| 102 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.04972012 |
| 103 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.04662728 |
| 104 | negative regulation of cAMP biosynthetic process (GO:0030818) | 3.04468000 |
| 105 | behavioral defense response (GO:0002209) | 3.04396426 |
| 106 | behavioral fear response (GO:0001662) | 3.04396426 |
| 107 | neurotransmitter transport (GO:0006836) | 3.04137732 |
| 108 | primary amino compound metabolic process (GO:1901160) | 3.03963917 |
| 109 | amino acid import (GO:0043090) | 3.01715315 |
| 110 | mechanosensory behavior (GO:0007638) | 2.99952446 |
| 111 | negative regulation of lyase activity (GO:0051350) | 2.99763001 |
| 112 | response to amphetamine (GO:0001975) | 2.99684147 |
| 113 | learning (GO:0007612) | 2.99642587 |
| 114 | gamma-aminobutyric acid transport (GO:0015812) | 2.97636274 |
| 115 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.96270938 |
| 116 | behavioral response to nicotine (GO:0035095) | 2.95513067 |
| 117 | cAMP catabolic process (GO:0006198) | 2.95040447 |
| 118 | positive regulation of dendritic spine development (GO:0060999) | 2.94936976 |
| 119 | negative regulation of cyclic nucleotide biosynthetic process (GO:0030803) | 2.93650722 |
| 120 | drinking behavior (GO:0042756) | 2.92539978 |
| 121 | activation of protein kinase A activity (GO:0034199) | 2.91883404 |
| 122 | regulation of synaptic transmission (GO:0050804) | 2.91355701 |
| 123 | long term synaptic depression (GO:0060292) | 2.91204774 |
| 124 | adult behavior (GO:0030534) | 2.91098364 |
| 125 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.90653224 |
| 126 | endothelial cell chemotaxis (GO:0035767) | 2.90482366 |
| 127 | regulation of neurotransmitter levels (GO:0001505) | 2.87416973 |
| 128 | visual learning (GO:0008542) | 2.86842659 |
| 129 | negative regulation of nucleotide biosynthetic process (GO:0030809) | 2.84805175 |
| 130 | negative regulation of purine nucleotide biosynthetic process (GO:1900372) | 2.84805175 |
| 131 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.83955028 |
| 132 | startle response (GO:0001964) | 2.83047970 |
| 133 | calcium ion-dependent exocytosis (GO:0017156) | 2.80577592 |
| 134 | nucleoside diphosphate catabolic process (GO:0009134) | 2.78273320 |
| 135 | negative regulation of cAMP metabolic process (GO:0030815) | 2.76744817 |
| 136 | melanin biosynthetic process (GO:0042438) | 2.74060110 |
| 137 | synaptic transmission (GO:0007268) | 2.73452650 |
| 138 | adult feeding behavior (GO:0008343) | 2.73284064 |
| 139 | potassium ion transport (GO:0006813) | 2.67697882 |
| 140 | negative regulation of cyclic nucleotide metabolic process (GO:0030800) | 2.67646825 |
| 141 | positive regulation of dendrite development (GO:1900006) | 2.62682225 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.71908158 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.66869014 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.00777014 |
| 4 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.00593230 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.00240394 |
| 6 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.79102105 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.74406687 |
| 8 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.74406687 |
| 9 | * JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.58842614 |
| 10 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.54157839 |
| 11 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.53692360 |
| 12 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.52431982 |
| 13 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.51970212 |
| 14 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.47157570 |
| 15 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.38607179 |
| 16 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.38325308 |
| 17 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.38036707 |
| 18 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.34464653 |
| 19 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.28095735 |
| 20 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.24508905 |
| 21 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.23630503 |
| 22 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.09665618 |
| 23 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.97069361 |
| 24 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.96939911 |
| 25 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.94421848 |
| 26 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.90638694 |
| 27 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.87425725 |
| 28 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.84949702 |
| 29 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.83725062 |
| 30 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.78560847 |
| 31 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.75854759 |
| 32 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.65952023 |
| 33 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.55130575 |
| 34 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.52626271 |
| 35 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.51940630 |
| 36 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.49007553 |
| 37 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.48317820 |
| 38 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.45814219 |
| 39 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.45178611 |
| 40 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.44362031 |
| 41 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.44080076 |
| 42 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.40796477 |
| 43 | VDR_22108803_ChIP-Seq_LS180_Human | 1.39455038 |
| 44 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.37869827 |
| 45 | P300_19829295_ChIP-Seq_ESCs_Human | 1.35195447 |
| 46 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.34734043 |
| 47 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.32741802 |
| 48 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.31348799 |
| 49 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.31107387 |
| 50 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.30291037 |
| 51 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.28616217 |
| 52 | AR_25329375_ChIP-Seq_VCAP_Human | 1.25107526 |
| 53 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.24864457 |
| 54 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.24269968 |
| 55 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.22992337 |
| 56 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.22479714 |
| 57 | * AR_19668381_ChIP-Seq_PC3_Human | 1.22408063 |
| 58 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.20854096 |
| 59 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.19629610 |
| 60 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.19085633 |
| 61 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.18453473 |
| 62 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.17696525 |
| 63 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.17491672 |
| 64 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.14081321 |
| 65 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.13165179 |
| 66 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.12841730 |
| 67 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.12402926 |
| 68 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.12018972 |
| 69 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.12003446 |
| 70 | RXR_22108803_ChIP-Seq_LS180_Human | 1.11029679 |
| 71 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.10953146 |
| 72 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.10851493 |
| 73 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.10144178 |
| 74 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.10099266 |
| 75 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.09886656 |
| 76 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.09760758 |
| 77 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.09543055 |
| 78 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.08147952 |
| 79 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.06959616 |
| 80 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.06891210 |
| 81 | * TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.05815640 |
| 82 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05693055 |
| 83 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.05693055 |
| 84 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.05003858 |
| 85 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03283907 |
| 86 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.03163464 |
| 87 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.03070672 |
| 88 | * MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.01988173 |
| 89 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.01691722 |
| 90 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.01038030 |
| 91 | * RUNX2_22187159_ChIP-Seq_PCA_Human | 1.00696770 |
| 92 | * YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.00560206 |
| 93 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.99483513 |
| 94 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.97843054 |
| 95 | KDM2B_26808549_Chip-Seq_K562_Human | 0.96632572 |
| 96 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.96115694 |
| 97 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.96071252 |
| 98 | * TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.96059319 |
| 99 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.95500489 |
| 100 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.95069922 |
| 101 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.93384357 |
| 102 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.92776145 |
| 103 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.91766951 |
| 104 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.90171541 |
| 105 | TP53_16413492_ChIP-PET_HCT116_Human | 0.90003880 |
| 106 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.89926485 |
| 107 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.89870257 |
| 108 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.89758307 |
| 109 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.88501967 |
| 110 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.88494359 |
| 111 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.88432198 |
| 112 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.88352657 |
| 113 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.88239540 |
| 114 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.88156020 |
| 115 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.87393758 |
| 116 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.87345736 |
| 117 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.87130051 |
| 118 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.86522175 |
| 119 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.86275585 |
| 120 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.85663067 |
| 121 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.85268282 |
| 122 | * STAT3_18555785_ChIP-Seq_MESCs_Mouse | 0.79059109 |
| 123 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.78797203 |
| 124 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.78681382 |
| 125 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.78174543 |
| 126 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.78097053 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.36249143 |
| 2 | MP0002822_catalepsy | 4.65532545 |
| 3 | MP0003880_abnormal_central_pattern | 4.43262539 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.96666887 |
| 5 | MP0009745_abnormal_behavioral_response | 3.38908353 |
| 6 | MP0002063_abnormal_learning/memory/cond | 3.24549927 |
| 7 | MP0003136_yellow_coat_color | 3.18470947 |
| 8 | MP0005423_abnormal_somatic_nervous | 3.10896175 |
| 9 | MP0002064_seizures | 3.00987502 |
| 10 | MP0001486_abnormal_startle_reflex | 2.99187563 |
| 11 | MP0002572_abnormal_emotion/affect_behav | 2.91264035 |
| 12 | MP0009046_muscle_twitch | 2.88861945 |
| 13 | MP0001968_abnormal_touch/_nociception | 2.85963441 |
| 14 | MP0005670_abnormal_white_adipose | 2.69435027 |
| 15 | MP0004270_analgesia | 2.64737271 |
| 16 | MP0002272_abnormal_nervous_system | 2.48156640 |
| 17 | MP0003879_abnormal_hair_cell | 2.39119917 |
| 18 | MP0005646_abnormal_pituitary_gland | 2.24761220 |
| 19 | MP0001348_abnormal_lacrimal_gland | 2.21936719 |
| 20 | MP0002736_abnormal_nociception_after | 2.20887822 |
| 21 | MP0001501_abnormal_sleep_pattern | 2.16419533 |
| 22 | MP0002734_abnormal_mechanical_nocicepti | 2.10488842 |
| 23 | MP0005386_behavior/neurological_phenoty | 2.01546649 |
| 24 | MP0004924_abnormal_behavior | 2.01546649 |
| 25 | MP0002557_abnormal_social/conspecific_i | 1.99994993 |
| 26 | MP0001440_abnormal_grooming_behavior | 1.96308206 |
| 27 | MP0002735_abnormal_chemical_nociception | 1.94289653 |
| 28 | MP0005377_hearing/vestibular/ear_phenot | 1.89232341 |
| 29 | MP0003878_abnormal_ear_physiology | 1.89232341 |
| 30 | MP0005645_abnormal_hypothalamus_physiol | 1.86642785 |
| 31 | MP0002909_abnormal_adrenal_gland | 1.85553975 |
| 32 | MP0002067_abnormal_sensory_capabilities | 1.79496420 |
| 33 | MP0001529_abnormal_vocalization | 1.77304387 |
| 34 | MP0001970_abnormal_pain_threshold | 1.75150053 |
| 35 | MP0008004_abnormal_stomach_pH | 1.68537516 |
| 36 | MP0002184_abnormal_innervation | 1.66557826 |
| 37 | MP0000569_abnormal_digit_pigmentation | 1.64697108 |
| 38 | MP0002733_abnormal_thermal_nociception | 1.64113712 |
| 39 | MP0001984_abnormal_olfaction | 1.63029796 |
| 40 | MP0004858_abnormal_nervous_system | 1.62999228 |
| 41 | MP0008569_lethality_at_weaning | 1.62274404 |
| 42 | MP0004811_abnormal_neuron_physiology | 1.60346052 |
| 43 | MP0001502_abnormal_circadian_rhythm | 1.49829673 |
| 44 | MP0009780_abnormal_chondrocyte_physiolo | 1.48685751 |
| 45 | MP0006276_abnormal_autonomic_nervous | 1.47066805 |
| 46 | MP0000778_abnormal_nervous_system | 1.43930166 |
| 47 | MP0006292_abnormal_olfactory_placode | 1.41362549 |
| 48 | MP0004885_abnormal_endolymph | 1.38572511 |
| 49 | MP0004742_abnormal_vestibular_system | 1.32035397 |
| 50 | MP0002066_abnormal_motor_capabilities/c | 1.29776893 |
| 51 | MP0002249_abnormal_larynx_morphology | 1.28216569 |
| 52 | MP0002653_abnormal_ependyma_morphology | 1.26375968 |
| 53 | MP0003633_abnormal_nervous_system | 1.25720875 |
| 54 | MP0008874_decreased_physiological_sensi | 1.23632438 |
| 55 | MP0001188_hyperpigmentation | 1.20004707 |
| 56 | MP0001485_abnormal_pinna_reflex | 1.17226895 |
| 57 | MP0000955_abnormal_spinal_cord | 1.17085653 |
| 58 | MP0004085_abnormal_heartbeat | 1.16573425 |
| 59 | MP0002882_abnormal_neuron_morphology | 1.16564860 |
| 60 | MP0002138_abnormal_hepatobiliary_system | 1.15017643 |
| 61 | MP0000026_abnormal_inner_ear | 1.13630019 |
| 62 | MP0004130_abnormal_muscle_cell | 1.08976314 |
| 63 | MP0001177_atelectasis | 1.07817291 |
| 64 | MP0003646_muscle_fatigue | 1.06788918 |
| 65 | MP0001905_abnormal_dopamine_level | 1.00850534 |
| 66 | MP0000631_abnormal_neuroendocrine_gland | 0.98650593 |
| 67 | MP0005551_abnormal_eye_electrophysiolog | 0.97166617 |
| 68 | MP0008872_abnormal_physiological_respon | 0.96626809 |
| 69 | MP0004142_abnormal_muscle_tone | 0.95407467 |
| 70 | MP0002069_abnormal_eating/drinking_beha | 0.94646208 |
| 71 | MP0003631_nervous_system_phenotype | 0.94012702 |
| 72 | MP0003787_abnormal_imprinting | 0.93333017 |
| 73 | MP0002152_abnormal_brain_morphology | 0.92988253 |
| 74 | MP0005409_darkened_coat_color | 0.92836989 |
| 75 | MP0000751_myopathy | 0.92700571 |
| 76 | MP0003075_altered_response_to | 0.88848099 |
| 77 | MP0003283_abnormal_digestive_organ | 0.88544310 |
| 78 | MP0002638_abnormal_pupillary_reflex | 0.86499567 |
| 79 | MP0001963_abnormal_hearing_physiology | 0.84582220 |
| 80 | MP0004215_abnormal_myocardial_fiber | 0.84553080 |
| 81 | MP0003137_abnormal_impulse_conducting | 0.84318845 |
| 82 | MP0005167_abnormal_blood-brain_barrier | 0.83718143 |
| 83 | MP0002090_abnormal_vision | 0.83195339 |
| 84 | MP0008961_abnormal_basal_metabolism | 0.80445494 |
| 85 | MP0001664_abnormal_digestion | 0.79276019 |
| 86 | MP0003329_amyloid_beta_deposits | 0.79215752 |
| 87 | MP0003119_abnormal_digestive_system | 0.78777054 |
| 88 | MP0003122_maternal_imprinting | 0.77693052 |
| 89 | MP0004043_abnormal_pH_regulation | 0.74020600 |
| 90 | MP0002229_neurodegeneration | 0.73981825 |
| 91 | MP0010386_abnormal_urinary_bladder | 0.72411330 |
| 92 | MP0005171_absent_coat_pigmentation | 0.70856520 |
| 93 | MP0004133_heterotaxia | 0.70202003 |
| 94 | MP0000678_abnormal_parathyroid_gland | 0.69349495 |
| 95 | MP0003632_abnormal_nervous_system | 0.68419176 |
| 96 | MP0003690_abnormal_glial_cell | 0.67468662 |
| 97 | MP0002928_abnormal_bile_duct | 0.67292554 |
| 98 | MP0005535_abnormal_body_temperature | 0.67277325 |
| 99 | MP0001765_abnormal_ion_homeostasis | 0.66813282 |
| 100 | MP0004145_abnormal_muscle_electrophysio | 0.66424899 |
| 101 | MP0003868_abnormal_feces_composition | 0.65538192 |
| 102 | MP0003634_abnormal_glial_cell | 0.64881508 |
| 103 | MP0003172_abnormal_lysosome_physiology | 0.64390348 |
| 104 | MP0004484_altered_response_of | 0.61738299 |
| 105 | MP0002752_abnormal_somatic_nervous | 0.61182905 |
| 106 | MP0004381_abnormal_hair_follicle | 0.61126473 |
| 107 | MP0000920_abnormal_myelination | 0.61024510 |
| 108 | MP0003861_abnormal_nervous_system | 0.60845803 |
| 109 | MP0005448_abnormal_energy_balance | 0.58851881 |
| 110 | MP0002876_abnormal_thyroid_physiology | 0.58790256 |
| 111 | MP0005499_abnormal_olfactory_system | 0.58280698 |
| 112 | MP0005394_taste/olfaction_phenotype | 0.58280698 |
| 113 | MP0000230_abnormal_systemic_arterial | 0.58230257 |
| 114 | MP0004233_abnormal_muscle_weight | 0.57900610 |
| 115 | MP0001986_abnormal_taste_sensitivity | 0.56673419 |
| 116 | MP0003183_abnormal_peptide_metabolism | 0.55789850 |
| 117 | MP0002837_dystrophic_cardiac_calcinosis | 0.55700412 |
| 118 | MP0003953_abnormal_hormone_level | 0.54120180 |
| 119 | MP0003195_calcinosis | 0.53625507 |
| 120 | MP0000049_abnormal_middle_ear | 0.51746892 |
| 121 | MP0003045_fibrosis | 0.51732638 |
| 122 | MP0005248_abnormal_Harderian_gland | 0.51422096 |
| 123 | MP0005253_abnormal_eye_physiology | 0.50002460 |
| 124 | MP0004036_abnormal_muscle_relaxation | 0.48703159 |
| 125 | MP0010769_abnormal_survival | 0.48378794 |
| 126 | MP0004510_myositis | 0.47156341 |
| 127 | MP0002234_abnormal_pharynx_morphology | 0.46602593 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.55055919 |
| 2 | Myokymia (HP:0002411) | 7.21134908 |
| 3 | Focal seizures (HP:0007359) | 5.29870740 |
| 4 | Febrile seizures (HP:0002373) | 4.55192802 |
| 5 | Epileptic encephalopathy (HP:0200134) | 4.35066112 |
| 6 | Retinal dysplasia (HP:0007973) | 4.26841033 |
| 7 | Poor eye contact (HP:0000817) | 4.21048227 |
| 8 | Visual hallucinations (HP:0002367) | 4.01111909 |
| 9 | Abnormal social behavior (HP:0012433) | 3.70516191 |
| 10 | Impaired social interactions (HP:0000735) | 3.70516191 |
| 11 | Broad-based gait (HP:0002136) | 3.68881429 |
| 12 | Generalized tonic-clonic seizures (HP:0002069) | 3.43234171 |
| 13 | Action tremor (HP:0002345) | 3.34667993 |
| 14 | Unilateral renal agenesis (HP:0000122) | 3.34599044 |
| 15 | Progressive cerebellar ataxia (HP:0002073) | 3.31735886 |
| 16 | Gaze-evoked nystagmus (HP:0000640) | 3.19593137 |
| 17 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 3.17980432 |
| 18 | Absence seizures (HP:0002121) | 3.15994187 |
| 19 | Prolonged QT interval (HP:0001657) | 3.08667665 |
| 20 | Postural instability (HP:0002172) | 3.08329406 |
| 21 | Narrow nasal bridge (HP:0000446) | 3.04826721 |
| 22 | Hyperventilation (HP:0002883) | 3.04276145 |
| 23 | Hypoplasia of the iris (HP:0007676) | 3.04065907 |
| 24 | Parakeratosis (HP:0001036) | 3.03495690 |
| 25 | Atonic seizures (HP:0010819) | 3.00802340 |
| 26 | Supranuclear gaze palsy (HP:0000605) | 2.99258611 |
| 27 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.98720106 |
| 28 | Dialeptic seizures (HP:0011146) | 2.94681455 |
| 29 | Absent/shortened dynein arms (HP:0200106) | 2.91911956 |
| 30 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.91911956 |
| 31 | Absent eyebrow (HP:0002223) | 2.91767592 |
| 32 | Depression (HP:0000716) | 2.90413020 |
| 33 | Ankle clonus (HP:0011448) | 2.88867748 |
| 34 | Abnormal EKG (HP:0003115) | 2.86787316 |
| 35 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.85799905 |
| 36 | Abnormality of the diencephalon (HP:0010662) | 2.84080317 |
| 37 | Decreased circulating renin level (HP:0003351) | 2.83409676 |
| 38 | Anxiety (HP:0000739) | 2.79065925 |
| 39 | Congenital stationary night blindness (HP:0007642) | 2.77190950 |
| 40 | Decreased central vision (HP:0007663) | 2.74555184 |
| 41 | Dysdiadochokinesis (HP:0002075) | 2.73732361 |
| 42 | Poikiloderma (HP:0001029) | 2.70830680 |
| 43 | Anomalous pulmonary venous return (HP:0010772) | 2.68104745 |
| 44 | Severe visual impairment (HP:0001141) | 2.66495517 |
| 45 | Torticollis (HP:0000473) | 2.65889591 |
| 46 | Abnormality of dental color (HP:0011073) | 2.64404875 |
| 47 | Clumsiness (HP:0002312) | 2.63994291 |
| 48 | Follicular hyperkeratosis (HP:0007502) | 2.63800765 |
| 49 | Annular pancreas (HP:0001734) | 2.61441693 |
| 50 | Alopecia of scalp (HP:0002293) | 2.58731229 |
| 51 | Agitation (HP:0000713) | 2.58052669 |
| 52 | EEG with generalized epileptiform discharges (HP:0011198) | 2.57936233 |
| 53 | Dysmetria (HP:0001310) | 2.57202795 |
| 54 | Papilledema (HP:0001085) | 2.56923973 |
| 55 | Hypoplastic ischia (HP:0003175) | 2.53970384 |
| 56 | Atrial fibrillation (HP:0005110) | 2.52296682 |
| 57 | Truncal ataxia (HP:0002078) | 2.51353783 |
| 58 | Stereotypic behavior (HP:0000733) | 2.50144551 |
| 59 | Absent speech (HP:0001344) | 2.46120724 |
| 60 | Pointed chin (HP:0000307) | 2.46008337 |
| 61 | Primary atrial arrhythmia (HP:0001692) | 2.45267923 |
| 62 | Abnormality of the ischium (HP:0003174) | 2.43557121 |
| 63 | Fetal akinesia sequence (HP:0001989) | 2.40743847 |
| 64 | Bilateral sensorineural hearing impairment (HP:0008619) | 2.39962681 |
| 65 | Absent eyelashes (HP:0000561) | 2.39766108 |
| 66 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 2.36159552 |
| 67 | Excessive salivation (HP:0003781) | 2.34283360 |
| 68 | Drooling (HP:0002307) | 2.34283360 |
| 69 | Syncope (HP:0001279) | 2.33440188 |
| 70 | Urinary urgency (HP:0000012) | 2.31002576 |
| 71 | Protruding tongue (HP:0010808) | 2.28620683 |
| 72 | Supraventricular tachycardia (HP:0004755) | 2.28348358 |
| 73 | Hypsarrhythmia (HP:0002521) | 2.28082888 |
| 74 | Focal dystonia (HP:0004373) | 2.24362151 |
| 75 | Abnormality of the pulmonary veins (HP:0011718) | 2.24072128 |
| 76 | Abnormality of renin-angiotensin system (HP:0000847) | 2.23130588 |
| 77 | Areflexia of lower limbs (HP:0002522) | 2.22654534 |
| 78 | Impaired smooth pursuit (HP:0007772) | 2.22230388 |
| 79 | Abnormal eating behavior (HP:0100738) | 2.21171200 |
| 80 | Oligodontia (HP:0000677) | 2.21050584 |
| 81 | Supraventricular arrhythmia (HP:0005115) | 2.19077662 |
| 82 | Insomnia (HP:0100785) | 2.17843698 |
| 83 | Limb dystonia (HP:0002451) | 2.17729843 |
| 84 | Ventricular fibrillation (HP:0001663) | 2.17212260 |
| 85 | Sleep apnea (HP:0010535) | 2.17079219 |
| 86 | Spinal canal stenosis (HP:0003416) | 2.14776779 |
| 87 | Diplopia (HP:0000651) | 2.14106460 |
| 88 | Abnormality of binocular vision (HP:0011514) | 2.14106460 |
| 89 | Bradykinesia (HP:0002067) | 2.13332069 |
| 90 | Scanning speech (HP:0002168) | 2.11719891 |
| 91 | Polydipsia (HP:0001959) | 2.11497814 |
| 92 | Abnormal drinking behavior (HP:0030082) | 2.11497814 |
| 93 | Spastic gait (HP:0002064) | 2.10255310 |
| 94 | Lower limb amyotrophy (HP:0007210) | 2.08949957 |
| 95 | Abnormality of magnesium homeostasis (HP:0004921) | 2.08827436 |
| 96 | Hemiplegia (HP:0002301) | 2.06396202 |
| 97 | Abnormality of the pubic bones (HP:0003172) | 2.06148185 |
| 98 | Heart block (HP:0012722) | 2.05666377 |
| 99 | Hemiparesis (HP:0001269) | 2.05468554 |
| 100 | Bundle branch block (HP:0011710) | 2.04604987 |
| 101 | Progressive inability to walk (HP:0002505) | 2.01279345 |
| 102 | Craniofacial dystonia (HP:0012179) | 2.01094078 |
| 103 | Genetic anticipation (HP:0003743) | 1.98994506 |
| 104 | Incomplete penetrance (HP:0003829) | 1.97555093 |
| 105 | Impaired vibratory sensation (HP:0002495) | 1.97157004 |
| 106 | Atrioventricular block (HP:0001678) | 1.96252669 |
| 107 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.95468149 |
| 108 | Autism (HP:0000717) | 1.94807199 |
| 109 | Dysmetric saccades (HP:0000641) | 1.94295708 |
| 110 | Intention tremor (HP:0002080) | 1.93156902 |
| 111 | Sudden death (HP:0001699) | 1.92723744 |
| 112 | Mutism (HP:0002300) | 1.92316543 |
| 113 | Blue irides (HP:0000635) | 1.91091147 |
| 114 | Deeply set eye (HP:0000490) | 1.90782752 |
| 115 | Myotonia (HP:0002486) | 1.90482684 |
| 116 | Gait ataxia (HP:0002066) | 1.90119676 |
| 117 | Obstructive sleep apnea (HP:0002870) | 1.90004445 |
| 118 | Ankyloglossia (HP:0010296) | 1.89380543 |
| 119 | Hypoplasia of the pons (HP:0012110) | 1.89339592 |
| 120 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.89008967 |
| 121 | Abnormality of alanine metabolism (HP:0010916) | 1.89008967 |
| 122 | Hyperalaninemia (HP:0003348) | 1.89008967 |
| 123 | Status epilepticus (HP:0002133) | 1.88755580 |
| 124 | Resting tremor (HP:0002322) | 1.87107739 |
| 125 | Amblyopia (HP:0000646) | 1.86333704 |
| 126 | Sclerocornea (HP:0000647) | 1.85755291 |
| 127 | Megalencephaly (HP:0001355) | 1.85743759 |
| 128 | Hyperphosphatemia (HP:0002905) | 1.85368954 |
| 129 | Hyperkalemia (HP:0002153) | 1.84421319 |
| 130 | Recurrent corneal erosions (HP:0000495) | 1.83552539 |
| 131 | Widely spaced teeth (HP:0000687) | 1.83543357 |
| 132 | Epileptiform EEG discharges (HP:0011182) | 1.80630505 |
| 133 | Inability to walk (HP:0002540) | 1.80084324 |
| 134 | Elfin facies (HP:0004428) | 1.79867485 |
| 135 | Gastroesophageal reflux (HP:0002020) | 1.79082907 |
| 136 | Renovascular hypertension (HP:0100817) | 1.76557324 |
| 137 | Spastic tetraparesis (HP:0001285) | 1.75028699 |
| 138 | Gait imbalance (HP:0002141) | 1.73569572 |
| 139 | Polyuria (HP:0000103) | 1.73171572 |
| 140 | Dysautonomia (HP:0002459) | 1.68319893 |
| 141 | Hypoventilation (HP:0002791) | 1.66801307 |
| 142 | Central scotoma (HP:0000603) | 1.65855662 |
| 143 | Abnormality of the anterior chamber (HP:0000593) | 1.63363150 |
| 144 | Down-sloping shoulders (HP:0200021) | 1.60316603 |
| 145 | Proximal tubulopathy (HP:0000114) | 1.60175601 |
| 146 | Hyperaldosteronism (HP:0000859) | 1.59829636 |
| 147 | Psychosis (HP:0000709) | 1.59746191 |
| 148 | Short 4th metacarpal (HP:0010044) | 1.59566420 |
| 149 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.59566420 |
| 150 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.57217295 |
| 151 | Abnormality of the pons (HP:0007361) | 1.54800176 |
| 152 | Abnormality of DNA repair (HP:0003254) | 1.54001674 |
| 153 | Abolished electroretinogram (ERG) (HP:0000550) | 1.53741586 |
| 154 | Abnormality of the 4th metacarpal (HP:0010012) | 1.53455546 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | STK16 | 7.91308694 |
| 2 | EPHA4 | 6.18028448 |
| 3 | NTRK3 | 4.67004944 |
| 4 | FRK | 3.60019970 |
| 5 | SIK2 | 3.42017842 |
| 6 | SIK3 | 3.15976636 |
| 7 | MAP3K9 | 2.83390412 |
| 8 | DAPK2 | 2.69241619 |
| 9 | MAP3K4 | 2.46046849 |
| 10 | RIPK4 | 2.18811019 |
| 11 | MAP2K7 | 2.18029810 |
| 12 | NTRK2 | 2.06782123 |
| 13 | MARK1 | 1.98360262 |
| 14 | PRPF4B | 1.97870253 |
| 15 | MINK1 | 1.85846965 |
| 16 | CAMKK1 | 1.84351890 |
| 17 | TNIK | 1.84190747 |
| 18 | PRKD3 | 1.83251608 |
| 19 | PAK6 | 1.78034184 |
| 20 | STK38 | 1.73160451 |
| 21 | BMPR1B | 1.69152047 |
| 22 | CDK12 | 1.63651759 |
| 23 | KSR2 | 1.61198064 |
| 24 | MAP2K4 | 1.59018910 |
| 25 | MAP3K12 | 1.56892246 |
| 26 | MAP3K13 | 1.55225916 |
| 27 | BLK | 1.49849562 |
| 28 | DAPK1 | 1.44725790 |
| 29 | CDK5 | 1.38839857 |
| 30 | FES | 1.37215440 |
| 31 | KSR1 | 1.33787706 |
| 32 | MAPK13 | 1.32981561 |
| 33 | SIK1 | 1.32968852 |
| 34 | SGK2 | 1.27362589 |
| 35 | CAMK1D | 1.26150352 |
| 36 | TRIB3 | 1.24279515 |
| 37 | CAMK1 | 1.19460459 |
| 38 | CASK | 1.17845864 |
| 39 | SGK223 | 1.16389913 |
| 40 | SGK494 | 1.16389913 |
| 41 | NTRK1 | 1.12967641 |
| 42 | MARK2 | 1.07134433 |
| 43 | SGK3 | 1.05407190 |
| 44 | TAOK1 | 1.03146482 |
| 45 | MAPK12 | 1.01002573 |
| 46 | PINK1 | 0.98354421 |
| 47 | CAMKK2 | 0.98039686 |
| 48 | PDK2 | 0.97778240 |
| 49 | PRKCG | 0.97138245 |
| 50 | TNK2 | 0.92188794 |
| 51 | SGK1 | 0.88782540 |
| 52 | GRK5 | 0.87593405 |
| 53 | STK11 | 0.87554684 |
| 54 | CAMK2A | 0.86975139 |
| 55 | PKN1 | 0.86413077 |
| 56 | PRKCH | 0.85217096 |
| 57 | PLK2 | 0.84750317 |
| 58 | BMPR2 | 0.83311781 |
| 59 | ICK | 0.82189322 |
| 60 | PHKG2 | 0.81348721 |
| 61 | PHKG1 | 0.81348721 |
| 62 | CAMK4 | 0.80816323 |
| 63 | UHMK1 | 0.80646815 |
| 64 | TYRO3 | 0.79798895 |
| 65 | MARK3 | 0.78929049 |
| 66 | GRK1 | 0.77354592 |
| 67 | LATS1 | 0.76989120 |
| 68 | ADRBK2 | 0.75970139 |
| 69 | WNK1 | 0.72409608 |
| 70 | LMTK2 | 0.72244512 |
| 71 | ALK | 0.72225919 |
| 72 | TAOK2 | 0.68727378 |
| 73 | MAP3K2 | 0.66597020 |
| 74 | ARAF | 0.64201773 |
| 75 | INSRR | 0.63520846 |
| 76 | LATS2 | 0.63143333 |
| 77 | PRKAA1 | 0.62191600 |
| 78 | WNK4 | 0.61671648 |
| 79 | ADRBK1 | 0.60050422 |
| 80 | ACVR1B | 0.59266471 |
| 81 | TGFBR1 | 0.58205984 |
| 82 | DYRK1A | 0.56920673 |
| 83 | CDK18 | 0.55138454 |
| 84 | CDK15 | 0.54579533 |
| 85 | RPS6KA2 | 0.53788439 |
| 86 | CDK3 | 0.53424308 |
| 87 | CAMK2B | 0.53396198 |
| 88 | RPS6KA6 | 0.52765242 |
| 89 | CDK19 | 0.52134350 |
| 90 | RPS6KA3 | 0.51809824 |
| 91 | RET | 0.51024014 |
| 92 | RAF1 | 0.50772455 |
| 93 | PDK1 | 0.50266663 |
| 94 | PTK2B | 0.50020573 |
| 95 | MUSK | 0.48294292 |
| 96 | CDK14 | 0.48039999 |
| 97 | MTOR | 0.46009705 |
| 98 | PAK3 | 0.45982994 |
| 99 | FYN | 0.45682637 |
| 100 | CSNK1A1 | 0.44864880 |
| 101 | MAP3K1 | 0.44840785 |
| 102 | ERBB2 | 0.44527175 |
| 103 | PDPK1 | 0.44306413 |
| 104 | DYRK2 | 0.44195205 |
| 105 | CDK11A | 0.44173762 |
| 106 | NEK6 | 0.43804642 |
| 107 | CDC42BPA | 0.43663905 |
| 108 | CAMK1G | 0.43477287 |
| 109 | PRKAA2 | 0.42820865 |
| 110 | PRKCE | 0.42139471 |
| 111 | DMPK | 0.41719375 |
| 112 | GSK3B | 0.41670663 |
| 113 | DDR2 | 0.41458488 |
| 114 | MAPK8 | 0.40864195 |
| 115 | PRKCZ | 0.40805130 |
| 116 | NEK1 | 0.39329591 |
| 117 | MAPK10 | 0.39328307 |
| 118 | MAPKAPK5 | 0.37899578 |
| 119 | PRKACA | 0.37735594 |
| 120 | CSNK1G2 | 0.37462210 |
| 121 | MAP3K7 | 0.37264204 |
| 122 | RIPK1 | 0.37167532 |
| 123 | MAP4K2 | 0.35725303 |
| 124 | PRKG1 | 0.34391199 |
| 125 | CDK8 | 0.34376169 |
| 126 | MAP2K1 | 0.34317948 |
| 127 | TLK1 | 0.33865545 |
| 128 | CSNK1D | 0.33603727 |
| 129 | TAOK3 | 0.33023251 |
| 130 | PNCK | 0.32947008 |
| 131 | FGR | 0.32547907 |
| 132 | CAMK2G | 0.32145933 |
| 133 | PRKCA | 0.31487665 |
| 134 | CCNB1 | 0.31430868 |
| 135 | WNK3 | 0.30542732 |
| 136 | MAPK14 | 0.29865021 |
| 137 | BRSK1 | 0.29804289 |
| 138 | PRKCB | 0.29049474 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.59753139 |
| 2 | Olfactory transduction_Homo sapiens_hsa04740 | 3.09345187 |
| 3 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.84557961 |
| 4 | Morphine addiction_Homo sapiens_hsa05032 | 2.83859548 |
| 5 | Circadian entrainment_Homo sapiens_hsa04713 | 2.75272120 |
| 6 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.61536476 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.60259146 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.57142334 |
| 9 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.40377670 |
| 10 | Long-term potentiation_Homo sapiens_hsa04720 | 2.38709414 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.07891254 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.06245338 |
| 13 | Cholinergic synapse_Homo sapiens_hsa04725 | 2.01441794 |
| 14 | Cocaine addiction_Homo sapiens_hsa05030 | 1.99867626 |
| 15 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.99808734 |
| 16 | Insulin secretion_Homo sapiens_hsa04911 | 1.98119267 |
| 17 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.90520735 |
| 18 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.83762712 |
| 19 | Renin secretion_Homo sapiens_hsa04924 | 1.79857186 |
| 20 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.73221304 |
| 21 | Taste transduction_Homo sapiens_hsa04742 | 1.70829616 |
| 22 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.69624659 |
| 23 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.68228217 |
| 24 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.60583582 |
| 25 | Long-term depression_Homo sapiens_hsa04730 | 1.45742443 |
| 26 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.41706392 |
| 27 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.39417857 |
| 28 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.38708407 |
| 29 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.37482411 |
| 30 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.32169850 |
| 31 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.30600529 |
| 32 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.26866652 |
| 33 | Gap junction_Homo sapiens_hsa04540 | 1.26505068 |
| 34 | Axon guidance_Homo sapiens_hsa04360 | 1.20273571 |
| 35 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.18978600 |
| 36 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.12050255 |
| 37 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.10397985 |
| 38 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.07058309 |
| 39 | Glioma_Homo sapiens_hsa05214 | 1.05065281 |
| 40 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.01357003 |
| 41 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.96387577 |
| 42 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.93625219 |
| 43 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.91142647 |
| 44 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.89637532 |
| 45 | Phototransduction_Homo sapiens_hsa04744 | 0.88990681 |
| 46 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.88546814 |
| 47 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.86759134 |
| 48 | ABC transporters_Homo sapiens_hsa02010 | 0.83665284 |
| 49 | Melanogenesis_Homo sapiens_hsa04916 | 0.82059780 |
| 50 | Lysine degradation_Homo sapiens_hsa00310 | 0.80218559 |
| 51 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.77566829 |
| 52 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.76675511 |
| 53 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.76548210 |
| 54 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.76385033 |
| 55 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.76377217 |
| 56 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.74377810 |
| 57 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.74106750 |
| 58 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.72984298 |
| 59 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.72947710 |
| 60 | Circadian rhythm_Homo sapiens_hsa04710 | 0.71261841 |
| 61 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.69709132 |
| 62 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.68885042 |
| 63 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.67068070 |
| 64 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.66006394 |
| 65 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.65213084 |
| 66 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.64919525 |
| 67 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.64072820 |
| 68 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.61933134 |
| 69 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.60160692 |
| 70 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.59337959 |
| 71 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.59092707 |
| 72 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.59021037 |
| 73 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.57095665 |
| 74 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.56744033 |
| 75 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.56716002 |
| 76 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.56667233 |
| 77 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.56115484 |
| 78 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.55290650 |
| 79 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.55243715 |
| 80 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.54808038 |
| 81 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.54782997 |
| 82 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.54149681 |
| 83 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.52546859 |
| 84 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.52216970 |
| 85 | Mineral absorption_Homo sapiens_hsa04978 | 0.51318577 |
| 86 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.51301347 |
| 87 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.50899951 |
| 88 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.50725719 |
| 89 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.49565109 |
| 90 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.49162970 |
| 91 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.48307674 |
| 92 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.48307003 |
| 93 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.47949625 |
| 94 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.47790862 |
| 95 | Alcoholism_Homo sapiens_hsa05034 | 0.47540849 |
| 96 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.47485083 |
| 97 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.46227553 |
| 98 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.44659790 |
| 99 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.43622810 |
| 100 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.43572251 |
| 101 | Endometrial cancer_Homo sapiens_hsa05213 | 0.43567901 |
| 102 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.42715239 |
| 103 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.40697007 |
| 104 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.39069156 |
| 105 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.38692471 |
| 106 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.38081748 |
| 107 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.37751692 |
| 108 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.37604583 |
| 109 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.37434521 |
| 110 | Bile secretion_Homo sapiens_hsa04976 | 0.37121139 |
| 111 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.36022197 |
| 112 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.35069367 |
| 113 | Endocytosis_Homo sapiens_hsa04144 | 0.34752338 |
| 114 | Melanoma_Homo sapiens_hsa05218 | 0.34401005 |
| 115 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.32012213 |
| 116 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.31563954 |
| 117 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.30226657 |
| 118 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.29960910 |
| 119 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.29853345 |
| 120 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.29710008 |
| 121 | Platelet activation_Homo sapiens_hsa04611 | 0.28458464 |
| 122 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.27386577 |
| 123 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.27320237 |
| 124 | Tight junction_Homo sapiens_hsa04530 | 0.26851672 |
| 125 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.23176489 |
| 126 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.22539390 |

