GSG1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of inhibitory postsynaptic membrane potential (GO:0060080)8.82592388
2negative regulation of vascular permeability (GO:0043116)8.52267272
3regulation of mononuclear cell migration (GO:0071675)8.51084013
4regulation of feeding behavior (GO:0060259)8.06696690
5negative regulation of axon guidance (GO:1902668)8.01547154
6regulation of catecholamine metabolic process (GO:0042069)7.81398511
7regulation of dopamine metabolic process (GO:0042053)7.81398511
8positive regulation of synaptic transmission, GABAergic (GO:0032230)7.11899334
9negative regulation of smooth muscle cell migration (GO:0014912)7.11885943
10regulation of monocyte chemotaxis (GO:0090025)6.44442289
11detection of light stimulus involved in sensory perception (GO:0050962)6.13394848
12detection of light stimulus involved in visual perception (GO:0050908)6.13394848
13positive regulation of amino acid transport (GO:0051957)5.95228555
14cell migration involved in sprouting angiogenesis (GO:0002042)5.76253557
15regulation of dopamine secretion (GO:0014059)5.71648221
16positive regulation of heart rate (GO:0010460)5.67802443
17regulation of axon guidance (GO:1902667)5.59130410
18membrane hyperpolarization (GO:0060081)5.44411897
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.17877161
20negative regulation of synaptic transmission, glutamatergic (GO:0051967)5.09582413
21motor neuron axon guidance (GO:0008045)4.99714366
22synaptic transmission, glutamatergic (GO:0035249)4.86613940
23response to morphine (GO:0043278)4.80694939
24hyperosmotic response (GO:0006972)4.62170128
25response to isoquinoline alkaloid (GO:0014072)4.56778456
26negative chemotaxis (GO:0050919)4.46894364
27mating behavior (GO:0007617)4.43657971
28retinal ganglion cell axon guidance (GO:0031290)4.28451034
29negative regulation of axon extension (GO:0030517)4.23754947
30neuron-neuron synaptic transmission (GO:0007270)4.14338935
31protein localization to synapse (GO:0035418)4.13650622
32response to salt stress (GO:0009651)4.05160785
33positive regulation of heart contraction (GO:0045823)4.04632568
34positive regulation of smooth muscle contraction (GO:0045987)4.00214513
35regulation of neutrophil chemotaxis (GO:0090022)3.97932875
36regulation of neutrophil migration (GO:1902622)3.97932875
37neuromuscular process controlling posture (GO:0050884)3.93244953
38apoptotic process involved in development (GO:1902742)3.89200672
39blood vessel endothelial cell migration (GO:0043534)3.69893670
40positive regulation of blood pressure (GO:0045777)3.61357625
41detection of temperature stimulus (GO:0016048)3.60954317
42ionotropic glutamate receptor signaling pathway (GO:0035235)3.60893844
43regulation of vascular permeability (GO:0043114)3.56195792
44negative regulation of leukocyte migration (GO:0002686)3.49693966
45startle response (GO:0001964)3.49677483
46regulation of lamellipodium assembly (GO:0010591)3.41201159
47regulation of short-term neuronal synaptic plasticity (GO:0048172)3.37254982
48synaptic vesicle endocytosis (GO:0048488)3.36217133
49response to cocaine (GO:0042220)3.34168981
50behavioral response to pain (GO:0048266)3.27983176
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.18202484
52detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.14941862
53detection of temperature stimulus involved in sensory perception (GO:0050961)3.14941862
54positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.14866187
55synaptic vesicle maturation (GO:0016188)3.14476330
56cellular potassium ion homeostasis (GO:0030007)3.12393845
57positive regulation of muscle contraction (GO:0045933)3.12302287
58iron coordination entity transport (GO:1901678)3.12062646
59regulation of amino acid transport (GO:0051955)3.10723506
60negative regulation of chemotaxis (GO:0050922)3.08063465
61glutamate receptor signaling pathway (GO:0007215)3.05529481
62righting reflex (GO:0060013)3.04910491
63axon extension (GO:0048675)3.04784636
64regulation of postsynaptic membrane potential (GO:0060078)3.03957782
65synaptic transmission, cholinergic (GO:0007271)3.03749909
66regulation of synaptic vesicle exocytosis (GO:2000300)3.02448196
67regulation of granulocyte chemotaxis (GO:0071622)3.00887277
68regulation of transmission of nerve impulse (GO:0051969)2.93350902
69synaptic vesicle exocytosis (GO:0016079)2.92536424
70negative regulation of cytokine-mediated signaling pathway (GO:0001960)2.88348656
71negative regulation of endothelial cell migration (GO:0010596)2.86421871
72retinal rod cell development (GO:0046548)2.85836227
73neuron projection extension (GO:1990138)2.81171869
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.79952025
75N-acetylglucosamine metabolic process (GO:0006044)2.77964266
76regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.77215701
77positive regulation of organic acid transport (GO:0032892)2.75102511
78regulation of smooth muscle cell migration (GO:0014910)2.73034073
79regulation of catecholamine secretion (GO:0050433)2.69979344
80negative regulation of small GTPase mediated signal transduction (GO:0051058)2.68903476
81membrane depolarization (GO:0051899)2.67617250
82regulation of lamellipodium organization (GO:1902743)2.65896364
83regulation of synaptic transmission, GABAergic (GO:0032228)2.63545605
84regulation of amine transport (GO:0051952)2.62725076
85fat-soluble vitamin biosynthetic process (GO:0042362)2.55917195
86regulation of cofactor metabolic process (GO:0051193)2.55647741
87regulation of coenzyme metabolic process (GO:0051196)2.55647741
88regulation of excitatory postsynaptic membrane potential (GO:0060079)2.53379885
89negative regulation of response to cytokine stimulus (GO:0060761)2.48326252
90innervation (GO:0060384)2.48157425
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46781902
92response to pheromone (GO:0019236)17.9317141
93tachykinin receptor signaling pathway (GO:0007217)15.5787026
94positive regulation of uterine smooth muscle contraction (GO:0070474)13.4938926
95hyperosmotic salinity response (GO:0042538)13.0070159
96negative regulation of leukocyte chemotaxis (GO:0002689)12.3814126
97regulation of chemokine-mediated signaling pathway (GO:0070099)11.4115149
98axon extension involved in axon guidance (GO:0048846)11.3137135
99neuron projection extension involved in neuron projection guidance (GO:1902284)11.3137135
100regulation of uterine smooth muscle contraction (GO:0070472)10.8608104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse7.71673388
2GBX2_23144817_ChIP-Seq_PC3_Human4.35948095
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.20203854
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.36769332
5TAF15_26573619_Chip-Seq_HEK293_Human3.30595378
6ZNF263_19887448_ChIP-Seq_K562_Human3.15704111
7EED_16625203_ChIP-ChIP_MESCs_Mouse3.11399102
8EZH2_22144423_ChIP-Seq_EOC_Human3.07572883
9VDR_22108803_ChIP-Seq_LS180_Human2.89834867
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68043423
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64618291
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61936537
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56340862
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47442227
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47442227
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45238438
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.30876113
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29940535
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29259331
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.21535428
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14310813
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00125123
23ZNF274_21170338_ChIP-Seq_K562_Hela1.99509198
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95237740
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93860847
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91550949
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.88110529
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.86509473
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86454685
30BCAT_22108803_ChIP-Seq_LS180_Human1.84272288
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79191401
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74541227
33REST_21632747_ChIP-Seq_MESCs_Mouse1.70402947
34P300_19829295_ChIP-Seq_ESCs_Human1.70126364
35DROSHA_22980978_ChIP-Seq_HELA_Human1.62331164
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.61021251
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60533736
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.56832766
39NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54744691
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.46972103
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.45303243
42TP53_16413492_ChIP-PET_HCT116_Human1.39751095
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39191702
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38301459
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.35495393
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35148951
47P53_22127205_ChIP-Seq_FIBROBLAST_Human1.33123534
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32961377
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30297052
50PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26788511
51GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.26399790
52YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19934979
53AR_25329375_ChIP-Seq_VCAP_Human1.17763460
54TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15920686
55SMAD4_21799915_ChIP-Seq_A2780_Human1.14428221
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.14226104
57EGR1_19032775_ChIP-ChIP_M12_Human1.09675963
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08370687
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07552237
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07109743
61SMAD4_21741376_ChIP-Seq_EPCs_Human1.03809827
62TP53_20018659_ChIP-ChIP_R1E_Mouse0.99479804
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99152214
64TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99045585
65ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98584866
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97522666
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97010571
68RXR_22108803_ChIP-Seq_LS180_Human0.96794856
69RING1B_27294783_Chip-Seq_ESCs_Mouse0.96746907
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96641737
71CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96629853
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95512301
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94812433
74TP53_22573176_ChIP-Seq_HFKS_Human0.94131752
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93362306
76SOX2_21211035_ChIP-Seq_LN229_Gbm0.93162175
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90497276
78EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88471870
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86235907
80EWS_26573619_Chip-Seq_HEK293_Human0.85535135
81GATA1_26923725_Chip-Seq_HPCs_Mouse0.83463833
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82755753
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82585201
84CDX2_20551321_ChIP-Seq_CACO-2_Human0.82516951
85BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81281693
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81210147
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81072035
88NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.80987713
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79782076
90RING1B_27294783_Chip-Seq_NPCs_Mouse0.78797658
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.78055280
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77777413
93ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77702827
94CTCF_27219007_Chip-Seq_Bcells_Human0.77248902
95AR_19668381_ChIP-Seq_PC3_Human0.76753808
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76217771
97RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75863750
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.73191213
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.73008542
100STAT3_23295773_ChIP-Seq_U87_Human0.71998047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception6.63256350
2MP0005551_abnormal_eye_electrophysiolog4.74475748
3MP0003880_abnormal_central_pattern4.10009181
4MP0010368_abnormal_lymphatic_system3.75508799
5MP0000534_abnormal_ureter_morphology3.58990258
6MP0004859_abnormal_synaptic_plasticity3.25743935
7MP0002736_abnormal_nociception_after3.16425874
8MP0003635_abnormal_synaptic_transmissio3.08168291
9MP0001968_abnormal_touch/_nociception3.06306927
10MP0002272_abnormal_nervous_system2.86609435
11MP0005423_abnormal_somatic_nervous2.80104581
12MP0004858_abnormal_nervous_system2.74447798
13MP0002090_abnormal_vision2.53918617
14MP0001486_abnormal_startle_reflex2.34689799
15MP0002064_seizures2.33638017
16MP0004510_myositis2.28873828
17MP0003950_abnormal_plasma_membrane2.15103781
18MP0002063_abnormal_learning/memory/cond2.14644543
19MP0003172_abnormal_lysosome_physiology1.99978647
20MP0004270_analgesia1.97390109
21MP0001440_abnormal_grooming_behavior1.97130731
22MP0002572_abnormal_emotion/affect_behav1.90342542
23MP0005670_abnormal_white_adipose1.88488406
24MP0003329_amyloid_beta_deposits1.86168287
25MP0001970_abnormal_pain_threshold1.83571979
26MP0003942_abnormal_urinary_system1.81631473
27MP0005253_abnormal_eye_physiology1.80833053
28MP0005623_abnormal_meninges_morphology1.79582137
29MP0005195_abnormal_posterior_eye1.60503910
30MP0009745_abnormal_behavioral_response1.59719312
31MP0004134_abnormal_chest_morphology1.58304531
32MP0008961_abnormal_basal_metabolism1.56121769
33MP0002733_abnormal_thermal_nociception1.54071132
34MP0009046_muscle_twitch1.52895885
35MP0002638_abnormal_pupillary_reflex1.51356545
36MP0003303_peritoneal_inflammation1.47650563
37MP0002067_abnormal_sensory_capabilities1.46287697
38MP0009840_abnormal_foam_cell1.39390695
39MP0003941_abnormal_skin_development1.39100229
40MP0003191_abnormal_cellular_cholesterol1.36290812
41MP0005365_abnormal_bile_salt1.35655005
42MP0006072_abnormal_retinal_apoptosis1.31445114
43MP0003279_aneurysm1.30852494
44MP0001502_abnormal_circadian_rhythm1.28606369
45MP0003633_abnormal_nervous_system1.26792601
46MP0003011_delayed_dark_adaptation1.23896863
47MP0002734_abnormal_mechanical_nocicepti1.19196224
48MP0002229_neurodegeneration1.17938929
49MP0003806_abnormal_nucleotide_metabolis1.16472001
50MP0001661_extended_life_span1.15935181
51MP0010329_abnormal_lipoprotein_level1.15049631
52MP0004885_abnormal_endolymph1.13368611
53MP0002909_abnormal_adrenal_gland1.12371991
54MP0008875_abnormal_xenobiotic_pharmacok1.10566862
55MP0002882_abnormal_neuron_morphology1.08082719
56MP0001879_abnormal_lymphatic_vessel1.05949265
57MP0000604_amyloidosis1.01145087
58MP0006276_abnormal_autonomic_nervous0.99681864
59MP0003879_abnormal_hair_cell0.99586209
60MP0003868_abnormal_feces_composition0.96460819
61MP0003631_nervous_system_phenotype0.95218610
62MP0002752_abnormal_somatic_nervous0.93747330
63MP0005360_urolithiasis0.92216740
64MP0000920_abnormal_myelination0.92183433
65MP0002066_abnormal_motor_capabilities/c0.91367920
66MP0004142_abnormal_muscle_tone0.88446821
67MP0004215_abnormal_myocardial_fiber0.87898115
68MP0002184_abnormal_innervation0.87067034
69MP0000013_abnormal_adipose_tissue0.86668767
70MP0005187_abnormal_penis_morphology0.82691437
71MP0010030_abnormal_orbit_morphology0.81734338
72MP0004145_abnormal_muscle_electrophysio0.81291203
73MP0002876_abnormal_thyroid_physiology0.80802967
74MP0002557_abnormal_social/conspecific_i0.80760628
75MP0005410_abnormal_fertilization0.79583972
76MP0002139_abnormal_hepatobiliary_system0.79514296
77MP0004811_abnormal_neuron_physiology0.79060298
78MP0005394_taste/olfaction_phenotype0.78581788
79MP0005499_abnormal_olfactory_system0.78581788
80MP0003283_abnormal_digestive_organ0.77699952
81MP0008569_lethality_at_weaning0.77098891
82MP0010386_abnormal_urinary_bladder0.76783585
83MP0000955_abnormal_spinal_cord0.76052138
84MP0008789_abnormal_olfactory_epithelium0.75677939
85MP0003634_abnormal_glial_cell0.73876633
86MP0009384_cardiac_valve_regurgitation0.73835903
87MP0005085_abnormal_gallbladder_physiolo0.72987550
88MP0004272_abnormal_basement_membrane0.72313238
89MP0000639_abnormal_adrenal_gland0.68542123
90MP0003632_abnormal_nervous_system0.68416111
91MP0005595_abnormal_vascular_smooth0.66910136
92MP0001324_abnormal_eye_pigmentation0.66156248
93MP0002108_abnormal_muscle_morphology0.65871564
94MP0001346_abnormal_lacrimal_gland0.65733294
95MP0008874_decreased_physiological_sensi0.64556765
96MP0008872_abnormal_physiological_respon0.64371245
97MP0001501_abnormal_sleep_pattern0.63769079
98MP0000631_abnormal_neuroendocrine_gland0.63516221
99MP0004924_abnormal_behavior0.61313992
100MP0005386_behavior/neurological_phenoty0.61313992

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.25120409
2Hypogonadotrophic hypogonadism (HP:0000044)5.63216061
3Decreased central vision (HP:0007663)5.57700108
4Cone-rod dystrophy (HP:0000548)5.02989215
5Erectile abnormalities (HP:0100639)4.92304761
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.70017514
7Abnormality of alanine metabolism (HP:0010916)4.70017514
8Hyperalaninemia (HP:0003348)4.70017514
9Breast aplasia (HP:0100783)4.57056607
10Central scotoma (HP:0000603)4.55239842
11Neoplasm of the heart (HP:0100544)4.42162247
12Septo-optic dysplasia (HP:0100842)4.41048166
13Abnormality of macular pigmentation (HP:0008002)4.12531395
14Severe visual impairment (HP:0001141)4.04789580
15Increased neuronal autofluorescent lipopigment (HP:0002074)4.02908751
16Focal seizures (HP:0007359)4.01395458
17Aplasia/Hypoplasia of the breasts (HP:0010311)3.95676510
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.89551855
19Focal motor seizures (HP:0011153)3.80896992
20Increased cerebral lipofuscin (HP:0011813)3.62184015
21Atonic seizures (HP:0010819)3.61970290
22Febrile seizures (HP:0002373)3.60098081
23Dialeptic seizures (HP:0011146)3.56144020
24Recurrent gram-negative bacterial infections (HP:0005420)3.52071745
25Ependymoma (HP:0002888)3.48185734
26Epileptic encephalopathy (HP:0200134)3.47210150
27Absence seizures (HP:0002121)3.46324298
28Scotoma (HP:0000575)3.44551579
29Decreased testicular size (HP:0008734)3.42265935
30Supernumerary spleens (HP:0009799)3.31580162
31Diplopia (HP:0000651)3.29134401
32Abnormality of binocular vision (HP:0011514)3.29134401
33Frequent falls (HP:0002359)2.94426206
34Abnormality of the astrocytes (HP:0100707)2.90567869
35Astrocytoma (HP:0009592)2.90567869
36Type 1 muscle fiber predominance (HP:0003803)2.87033544
37Chronic sinusitis (HP:0011109)2.84305248
38Absent septum pellucidum (HP:0001331)2.82580392
39Hyperlipoproteinemia (HP:0010980)2.80183611
40Abnormal rod and cone electroretinograms (HP:0008323)2.64229989
41Urinary bladder sphincter dysfunction (HP:0002839)2.63354514
42Facial shape deformation (HP:0011334)2.60972099
43Potter facies (HP:0002009)2.60972099
44Growth hormone deficiency (HP:0000824)2.60689268
45Generalized tonic-clonic seizures (HP:0002069)2.56584772
46Macular degeneration (HP:0000608)2.55454992
47Enlarged kidneys (HP:0000105)2.49711177
48Nemaline bodies (HP:0003798)2.46595065
49Abnormal drinking behavior (HP:0030082)2.45658532
50Polydipsia (HP:0001959)2.45658532
51Atelectasis (HP:0100750)2.45126044
52Rocker bottom foot (HP:0001838)2.44471717
53Abnormality of the septum pellucidum (HP:0007375)2.41228068
54Hypokinesia (HP:0002375)2.38253983
55Oral leukoplakia (HP:0002745)2.37076972
56Primary amenorrhea (HP:0000786)2.35103699
57Cholecystitis (HP:0001082)2.29901666
58Abnormal gallbladder physiology (HP:0012438)2.29901666
59Achilles tendon contracture (HP:0001771)2.27412941
60Gynecomastia (HP:0000771)2.26758231
61Spastic gait (HP:0002064)2.25649905
62Abnormality of the Achilles tendon (HP:0005109)2.25577585
63Clumsiness (HP:0002312)2.23106149
64Choroideremia (HP:0001139)2.19440471
65Hemiparesis (HP:0001269)2.19008269
66Tubulointerstitial fibrosis (HP:0005576)2.14536996
67Abolished electroretinogram (ERG) (HP:0000550)2.12323024
68Morphological abnormality of the middle ear (HP:0008609)2.11102879
69Recurrent bronchitis (HP:0002837)2.10949892
70Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10790462
71Abnormal sex determination (HP:0012244)2.06831934
72Sex reversal (HP:0012245)2.06831934
73Status epilepticus (HP:0002133)1.98893472
74EEG with generalized epileptiform discharges (HP:0011198)1.95086870
75Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93282870
76Long toe (HP:0010511)1.90554936
77Absent eyelashes (HP:0000561)1.89262205
78Epileptiform EEG discharges (HP:0011182)1.87939488
79Glioma (HP:0009733)1.87871337
80Aplastic anemia (HP:0001915)1.86923178
81Deep venous thrombosis (HP:0002625)1.85753323
82Visual hallucinations (HP:0002367)1.84844181
83Lymphangioma (HP:0100764)1.82731671
84Midline defect of the nose (HP:0004122)1.82482174
85Hypochromic microcytic anemia (HP:0004840)1.81694755
86Hemiplegia (HP:0002301)1.81101972
87Xanthomatosis (HP:0000991)1.77041823
88Abnormal eating behavior (HP:0100738)1.75765458
89Progressive visual loss (HP:0000529)1.72810939
90Abnormality of the periventricular white matter (HP:0002518)1.71661185
91Muscle fiber inclusion bodies (HP:0100299)1.68727516
92Anophthalmia (HP:0000528)1.68717749
93Oligodactyly (hands) (HP:0001180)1.67367337
94True hermaphroditism (HP:0010459)1.64972645
95Anteriorly placed anus (HP:0001545)1.64354158
96Stereotypic behavior (HP:0000733)1.64137954
97Micropenis (HP:0000054)1.64113623
98Pancreatic fibrosis (HP:0100732)1.63477905
99Absent speech (HP:0001344)1.62791673
100Polyphagia (HP:0002591)1.61157264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK38L5.14604140
2MARK14.63809196
3NEK14.31275824
4FES3.91823694
5EPHA33.77741782
6RIPK13.12725687
7STK382.96879707
8SIK12.77551202
9ERN12.49046498
10SIK22.19365815
11FER2.16844533
12PHKG21.95642931
13PHKG11.95642931
14WNK11.90731674
15PKN11.90025991
16LMTK21.76739768
17DYRK1A1.69718857
18CDK141.61446919
19MINK11.57456959
20CDK151.43808873
21MARK31.38005973
22CDK11A1.36046498
23CDK181.35879063
24PAK61.35430933
25DDR21.27278933
26NTRK11.08079556
27PRKAA11.07953587
28MAP3K121.07491877
29GRK11.05740516
30CDK51.01758310
31TAOK21.01662626
32PRKD31.01406234
33NTRK31.00651750
34ROCK20.96952519
35PAK30.96508799
36MAPK100.95183662
37EPHA40.94057187
38FGFR10.91376097
39SIK30.87855240
40CAMK2D0.83914416
41UHMK10.81058838
42TYK20.80968299
43MAPK90.80640290
44TAOK10.76684010
45DYRK1B0.76626596
46CDK190.75306050
47CDC42BPA0.74478159
48SGK2230.73170272
49SGK4940.73170272
50PRKCA0.67502817
51PTK60.65935867
52PRKCG0.63844365
53EGFR0.62693676
54CAMK2A0.61280427
55MAP2K40.60193243
56RIPK40.59654060
57CAMK10.59429602
58CSF1R0.58378162
59ADRBK10.58059226
60PRKCB0.57440377
61PASK0.57212654
62RPS6KA30.54506141
63MAPK40.54366149
64KSR20.51794147
65PRKCE0.51591853
66PDK40.49385551
67PDK30.49385551
68ERBB30.48851741
69GRK50.48639740
70FYN0.47398345
71FGR0.46597504
72SGK10.45954815
73TTN0.45041268
74CAMK1G0.42203586
75CAMKK10.42190046
76MAP3K110.40832588
77MATK0.39037385
78SRC0.35604493
79CSK0.35428797
80NTRK20.32616271
81MAP3K100.32410345
82PLK20.31436443
83FGFR40.30719524
84PRKACB0.29059261
85HIPK20.28540842
86CSNK1E0.28206438
87PRKCZ0.27758939
88MARK20.27751816
89ERBB20.26472471
90PLK30.25926891
91PRKDC0.25562659
92HCK0.24808497
93CAMK40.24182060
94MET0.23731173
95CAMK1D0.22349217
96CSNK1D0.21976842
97PRKACA0.21074625
98JAK10.19500270
99MAPK80.19279932
100MAP3K90.18275710

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050336.77899144
2Synaptic vesicle cycle_Homo sapiens_hsa047213.35367807
3GABAergic synapse_Homo sapiens_hsa047272.99807359
4Morphine addiction_Homo sapiens_hsa050322.77526017
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.64436144
6Circadian entrainment_Homo sapiens_hsa047132.54888017
7Cholinergic synapse_Homo sapiens_hsa047252.38326116
8Phototransduction_Homo sapiens_hsa047442.20339880
9Glutamatergic synapse_Homo sapiens_hsa047242.18407265
10Insulin secretion_Homo sapiens_hsa049112.08588285
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.97738244
12Dilated cardiomyopathy_Homo sapiens_hsa054141.82177227
13Renin secretion_Homo sapiens_hsa049241.81619529
14Calcium signaling pathway_Homo sapiens_hsa040201.77217220
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74187399
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.68510098
17Cardiac muscle contraction_Homo sapiens_hsa042601.60287466
18Oxytocin signaling pathway_Homo sapiens_hsa049211.59556137
19Bile secretion_Homo sapiens_hsa049761.58585041
20Collecting duct acid secretion_Homo sapiens_hsa049661.58290361
21Salivary secretion_Homo sapiens_hsa049701.56825135
22Long-term potentiation_Homo sapiens_hsa047201.55136095
23Taste transduction_Homo sapiens_hsa047421.53106816
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46153782
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44189159
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38277254
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32793761
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25712504
29Axon guidance_Homo sapiens_hsa043601.24177562
30Olfactory transduction_Homo sapiens_hsa047401.23380731
31Dopaminergic synapse_Homo sapiens_hsa047281.16291533
32Serotonergic synapse_Homo sapiens_hsa047261.15338645
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14069887
34Biosynthesis of amino acids_Homo sapiens_hsa012301.11899676
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09418305
36Inositol phosphate metabolism_Homo sapiens_hsa005621.05459228
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01080410
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97705675
39Vascular smooth muscle contraction_Homo sapiens_hsa042700.91698449
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90611510
41Long-term depression_Homo sapiens_hsa047300.87489958
42Nitrogen metabolism_Homo sapiens_hsa009100.86401538
43Pyruvate metabolism_Homo sapiens_hsa006200.85800410
44Pentose phosphate pathway_Homo sapiens_hsa000300.83000127
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82216098
46Estrogen signaling pathway_Homo sapiens_hsa049150.81698854
47Gastric acid secretion_Homo sapiens_hsa049710.80842962
48Vibrio cholerae infection_Homo sapiens_hsa051100.80400972
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.80385316
50Circadian rhythm_Homo sapiens_hsa047100.80097888
51Vitamin digestion and absorption_Homo sapiens_hsa049770.77297627
52Type II diabetes mellitus_Homo sapiens_hsa049300.74295954
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71973431
54Galactose metabolism_Homo sapiens_hsa000520.69615934
55Thyroid hormone synthesis_Homo sapiens_hsa049180.68681107
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67516423
57Fatty acid biosynthesis_Homo sapiens_hsa000610.67324616
58Fructose and mannose metabolism_Homo sapiens_hsa000510.66916271
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64368375
60Arginine biosynthesis_Homo sapiens_hsa002200.63509198
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.62994419
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58949805
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57521049
64Starch and sucrose metabolism_Homo sapiens_hsa005000.54315516
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52616134
66Lysosome_Homo sapiens_hsa041420.51274011
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49848055
68Fatty acid degradation_Homo sapiens_hsa000710.49314324
69Carbon metabolism_Homo sapiens_hsa012000.49198001
70GnRH signaling pathway_Homo sapiens_hsa049120.48682877
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46852750
72cAMP signaling pathway_Homo sapiens_hsa040240.45584256
73Fatty acid metabolism_Homo sapiens_hsa012120.45273787
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45079116
75Gap junction_Homo sapiens_hsa045400.43483444
76Amphetamine addiction_Homo sapiens_hsa050310.43298236
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.43167672
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.41954301
79Pancreatic secretion_Homo sapiens_hsa049720.40399642
80mTOR signaling pathway_Homo sapiens_hsa041500.39506670
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39097252
82Cocaine addiction_Homo sapiens_hsa050300.38947159
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37270591
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.36866898
85Complement and coagulation cascades_Homo sapiens_hsa046100.35428265
86Melanogenesis_Homo sapiens_hsa049160.33274797
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32332128
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32008401
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30328885
90Fatty acid elongation_Homo sapiens_hsa000620.29533790
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.29432242
92Oocyte meiosis_Homo sapiens_hsa041140.27645514
93Rheumatoid arthritis_Homo sapiens_hsa053230.26091602
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25411168
95Ovarian steroidogenesis_Homo sapiens_hsa049130.24956234
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24758261
97Platelet activation_Homo sapiens_hsa046110.24658924
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23032885
99Butanoate metabolism_Homo sapiens_hsa006500.21731980
100Phenylalanine metabolism_Homo sapiens_hsa003600.20872214

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