GSG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm-egg recognition (GO:0035036)9.80402378
2acrosome reaction (GO:0007340)9.51583776
3acrosome assembly (GO:0001675)9.41935878
4binding of sperm to zona pellucida (GO:0007339)9.21242311
5cell wall macromolecule metabolic process (GO:0044036)9.18382976
6cell wall macromolecule catabolic process (GO:0016998)9.18382976
7multicellular organism reproduction (GO:0032504)8.93103988
8cilium or flagellum-dependent cell motility (GO:0001539)8.85618196
9cell-cell recognition (GO:0009988)8.77478844
10axonemal dynein complex assembly (GO:0070286)8.64509677
11spermatid development (GO:0007286)8.41644988
12motile cilium assembly (GO:0044458)8.18681619
13piRNA metabolic process (GO:0034587)8.16401441
14plasma membrane fusion (GO:0045026)8.07990573
15epithelial cilium movement (GO:0003351)7.95435966
16reproduction (GO:0000003)7.50183214
17male meiosis (GO:0007140)7.32805729
18regulation of cilium movement (GO:0003352)7.21025658
19synaptonemal complex organization (GO:0070193)7.16950380
20synaptonemal complex assembly (GO:0007130)7.06379931
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.49960053
22DNA unwinding involved in DNA replication (GO:0006268)6.48000226
23cilium movement (GO:0003341)6.46862487
24mitotic chromosome condensation (GO:0007076)6.41766965
25microtubule depolymerization (GO:0007019)6.25827993
26single fertilization (GO:0007338)6.17779456
27negative regulation of inclusion body assembly (GO:0090084)5.88504158
28spermatogenesis (GO:0007283)5.80951530
29male gamete generation (GO:0048232)5.79474265
30fertilization (GO:0009566)5.47689168
31sperm capacitation (GO:0048240)5.45647802
32male meiosis I (GO:0007141)5.42705041
33DNA strand elongation involved in DNA replication (GO:0006271)5.41316789
34chromosome condensation (GO:0030261)5.38331902
35gamete generation (GO:0007276)5.37527095
36DNA strand elongation (GO:0022616)5.32952617
37DNA methylation involved in gamete generation (GO:0043046)5.27369853
38chromosome organization involved in meiosis (GO:0070192)5.17936507
39protein localization to kinetochore (GO:0034501)5.16495257
40DNA packaging (GO:0006323)5.12923840
41* protein localization to chromosome, centromeric region (GO:0071459)5.04511251
42mitotic metaphase plate congression (GO:0007080)4.99258847
43germ cell development (GO:0007281)4.89419622
44meiotic nuclear division (GO:0007126)4.87475925
45regulation of inclusion body assembly (GO:0090083)4.86943024
46organic cation transport (GO:0015695)4.79807066
47cellular process involved in reproduction in multicellular organism (GO:0022412)4.77416680
48telomere maintenance via semi-conservative replication (GO:0032201)4.70892450
49DNA replication initiation (GO:0006270)4.67845047
50meiosis I (GO:0007127)4.65814758
51seminiferous tubule development (GO:0072520)4.46934871
52monoubiquitinated protein deubiquitination (GO:0035520)4.34043918
53meiotic cell cycle (GO:0051321)4.32184514
54microtubule severing (GO:0051013)4.31588640
55DNA replication checkpoint (GO:0000076)4.29680567
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.25778950
57multicellular organismal reproductive process (GO:0048609)4.20298852
58positive regulation of chromosome segregation (GO:0051984)4.08324528
59ventricular system development (GO:0021591)4.07689321
60metaphase plate congression (GO:0051310)4.07639786
61regulation of microtubule-based movement (GO:0060632)4.07467481
62DNA topological change (GO:0006265)4.07294437
63membrane disassembly (GO:0030397)3.98580223
64nuclear envelope disassembly (GO:0051081)3.98580223
65telomere maintenance via recombination (GO:0000722)3.96785680
66chaperone-mediated protein complex assembly (GO:0051131)3.95158930
67regulation of spindle organization (GO:0090224)3.89387279
68cell recognition (GO:0008037)3.89262668
69glycerol ether metabolic process (GO:0006662)3.85211598
70nuclear pore complex assembly (GO:0051292)3.85093248
71mitotic recombination (GO:0006312)3.84116307
72regulation of sister chromatid cohesion (GO:0007063)3.83506997
73spermatid nucleus differentiation (GO:0007289)3.80460079
74regulation of translational fidelity (GO:0006450)3.79927601
75establishment of integrated proviral latency (GO:0075713)3.78250736
76calcium ion-dependent exocytosis (GO:0017156)3.77099410
77regulation of mitotic spindle organization (GO:0060236)3.72363910
78gene silencing by RNA (GO:0031047)3.72008189
79establishment of chromosome localization (GO:0051303)3.70752605
80DNA duplex unwinding (GO:0032508)3.67534885
81meiotic cell cycle process (GO:1903046)3.67401857
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.60978341
83single strand break repair (GO:0000012)3.55948528
84chromatin assembly (GO:0031497)3.55705453
85CENP-A containing nucleosome assembly (GO:0034080)3.54289093
86ether metabolic process (GO:0018904)3.53822142
87* mitotic sister chromatid cohesion (GO:0007064)3.53354317
88DNA geometric change (GO:0032392)3.52336804
89DNA replication-dependent nucleosome assembly (GO:0006335)3.50891457
90DNA replication-dependent nucleosome organization (GO:0034723)3.50891457
91left/right pattern formation (GO:0060972)3.50090477
92histone exchange (GO:0043486)3.47853655
93kinetochore organization (GO:0051383)3.44720829
94positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.44559956
95positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.44559956
96positive regulation of mitotic sister chromatid separation (GO:1901970)3.44559956
97chromatin assembly or disassembly (GO:0006333)3.43941198
98chromatin remodeling at centromere (GO:0031055)3.42876052
99chromosome segregation (GO:0007059)3.41449655
100formation of translation preinitiation complex (GO:0001731)3.40672423
101nuclear pore organization (GO:0006999)3.39188589
102nucleus organization (GO:0006997)3.39151054
103cellular protein complex localization (GO:0034629)3.36631523
104negative regulation of chromosome segregation (GO:0051985)3.36628388
105spliceosomal tri-snRNP complex assembly (GO:0000244)3.35996563
106multicellular organismal development (GO:0007275)3.32521004
107DNA synthesis involved in DNA repair (GO:0000731)3.30326745
108regulation of RNA export from nucleus (GO:0046831)3.27616483
109microtubule polymerization or depolymerization (GO:0031109)3.27031152
110* protein localization to chromosome (GO:0034502)3.26986130
111nucleotide-excision repair, DNA gap filling (GO:0006297)3.26750163
112regulation of translational termination (GO:0006449)3.23992874
113regulation of centriole replication (GO:0046599)3.22916290
114nuclear envelope organization (GO:0006998)3.22420500
115synapsis (GO:0007129)3.21357506
116DNA ligation (GO:0006266)3.20152922
117spindle checkpoint (GO:0031577)3.19588913
118genitalia morphogenesis (GO:0035112)3.19085135
119folic acid-containing compound biosynthetic process (GO:0009396)3.17812189
120interferon-gamma secretion (GO:0072643)3.17083500
121protein polyglutamylation (GO:0018095)3.16898536
122negative regulation of mRNA processing (GO:0050686)3.16064512
123ribosome assembly (GO:0042255)3.14357583
124regulation of mammary gland epithelial cell proliferation (GO:0033599)3.14355773
125regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14350364
126meiotic chromosome segregation (GO:0045132)3.14116340
127telomere maintenance via telomere lengthening (GO:0010833)3.14055590
128gene silencing (GO:0016458)3.13671795
129regulation of mitotic metaphase/anaphase transition (GO:0030071)3.13484268
130regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.13484268
131viral mRNA export from host cell nucleus (GO:0046784)3.12964856
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12147957
133negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.12147957
134negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12147957
135negative regulation of mitotic sister chromatid separation (GO:2000816)3.12147957
136negative regulation of sister chromatid segregation (GO:0033046)3.12147957
137DNA replication-independent nucleosome organization (GO:0034724)3.07241221
138DNA replication-independent nucleosome assembly (GO:0006336)3.07241221
139regulation of mitotic sister chromatid separation (GO:0010965)3.06817479
140regulation of mitotic sister chromatid segregation (GO:0033047)3.06817479
141regulation of sister chromatid segregation (GO:0033045)3.06817479
142regulation of histone H3-K9 methylation (GO:0051570)3.05881067
143ATP-dependent chromatin remodeling (GO:0043044)3.05283883
144maturation of SSU-rRNA (GO:0030490)3.04699660
145mitotic spindle checkpoint (GO:0071174)3.03124699
146pore complex assembly (GO:0046931)2.99706184
147mitotic sister chromatid segregation (GO:0000070)2.99597369
148protein refolding (GO:0042026)2.98570529
149mitotic spindle assembly checkpoint (GO:0007094)2.98248322
150double-strand break repair via nonhomologous end joining (GO:0006303)2.97764948
151non-recombinational repair (GO:0000726)2.97764948
152peptidyl-arginine omega-N-methylation (GO:0035247)2.95831676
153spindle assembly checkpoint (GO:0071173)2.95370454
154positive regulation of DNA-dependent DNA replication (GO:2000105)2.94898247
155protein complex localization (GO:0031503)2.94268744
156negative regulation of mRNA metabolic process (GO:1903312)2.93272421
157ribosome biogenesis (GO:0042254)2.91631425
158heterochromatin organization (GO:0070828)2.90444662
159negative regulation of RNA splicing (GO:0033119)2.89401624
160ribosomal small subunit biogenesis (GO:0042274)2.88530735
161IMP biosynthetic process (GO:0006188)2.87826187
162regulation of meiosis I (GO:0060631)2.80939114
163sequestering of actin monomers (GO:0042989)2.78082800
164DNA conformation change (GO:0071103)2.75978099
165translesion synthesis (GO:0019985)2.75947415
166* chromosome organization (GO:0051276)2.71738152
167regulation of chromosome segregation (GO:0051983)2.66502184
168centriole assembly (GO:0098534)2.65216084
169DNA alkylation (GO:0006305)2.64968505
170DNA methylation (GO:0006306)2.64968505
171protein-DNA complex disassembly (GO:0032986)2.64524716
172nucleosome disassembly (GO:0006337)2.64524716
173chromatin silencing (GO:0006342)2.64272848
174sister chromatid segregation (GO:0000819)2.61941698
175mitotic nuclear envelope disassembly (GO:0007077)2.61037164
176regulation of centrosome cycle (GO:0046605)2.60513838
177protein K11-linked deubiquitination (GO:0035871)2.60077642
178centriole replication (GO:0007099)2.59851421
179glycolytic process (GO:0006096)2.57459851
180protein localization to cilium (GO:0061512)2.56578992
181sperm motility (GO:0030317)11.0909638
182fusion of sperm to egg plasma membrane (GO:0007342)10.8001047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.99578410
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.86253419
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27225479
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.12341347
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.05673527
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.00640501
7* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.85234992
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49533418
9MYC_22102868_ChIP-Seq_BL_Human2.45696951
10XRN2_22483619_ChIP-Seq_HELA_Human2.31544217
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30622376
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25396430
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25068883
14* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21590888
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18291130
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.17959963
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17077691
18EZH2_22144423_ChIP-Seq_EOC_Human2.16885255
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10008733
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.06929455
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04176676
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.8771881
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97974856
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95875427
25DCP1A_22483619_ChIP-Seq_HELA_Human1.92210488
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.84441415
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82464518
28ZFX_18555785_ChIP-Seq_MESCs_Mouse1.80078516
29TTF2_22483619_ChIP-Seq_HELA_Human1.79946660
30CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74539590
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70549058
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.67150148
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65765107
34* GATA1_26923725_Chip-Seq_HPCs_Mouse1.65624761
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61075754
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.60457917
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59734510
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53170779
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52720505
40KDM5A_27292631_Chip-Seq_BREAST_Human1.51627449
41GABP_19822575_ChIP-Seq_HepG2_Human1.50954281
42KAP1_22055183_ChIP-Seq_ESCs_Mouse1.50668425
43ELK4_26923725_Chip-Seq_MESODERM_Mouse1.47119342
44* FOXP3_21729870_ChIP-Seq_TREG_Human1.42597773
45CIITA_25753668_ChIP-Seq_RAJI_Human1.41676532
46VDR_21846776_ChIP-Seq_THP-1_Human1.41613802
47SOX2_22085726_ChIP-Seq_NPCs_Mouse1.40619265
48* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40317668
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39988752
50GATA3_21867929_ChIP-Seq_CD8_Mouse1.37600274
51* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.36198273
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36007496
53CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.35439029
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35352677
55STAT1_17558387_ChIP-Seq_HELA_Human1.35269560
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33546361
57ZNF263_19887448_ChIP-Seq_K562_Human1.31928320
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.31661718
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30891790
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30449825
61* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29050393
62ZNF274_21170338_ChIP-Seq_K562_Hela1.28789162
63WDR5_24793694_ChIP-Seq_LNCAP_Human1.27762290
64VDR_22108803_ChIP-Seq_LS180_Human1.27016724
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26153024
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25827957
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24906576
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24855181
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23911089
70* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23671643
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.22454514
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21331826
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19659434
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19627483
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.19226977
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18230869
77VDR_23849224_ChIP-Seq_CD4+_Human1.17928589
78* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17071258
79MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15697001
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.15580467
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15161107
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14846696
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14082923
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13910415
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13444190
86CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13152521
87GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.12272732
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12053843
89KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10560253
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10436890
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09659472
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.08457908
93TFEB_21752829_ChIP-Seq_HELA_Human1.08088352
94P53_21459846_ChIP-Seq_SAOS-2_Human1.07069185
95* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06625501
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06454975
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06397554
98SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05313910
99STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04598950
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.03862213
101GATA3_21867929_ChIP-Seq_TH1_Mouse1.01839047
102ELK1_19687146_ChIP-ChIP_HELA_Human1.00018362
103RARA_24833708_ChIP-Seq_LIVER_Mouse0.99825610
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99673399
105* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99374867
106CHD1_26751641_Chip-Seq_LNCaP_Human0.99280084
107RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98597761
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98413136
109* AR_21909140_ChIP-Seq_LNCAP_Human0.97884251
110* SPI1_26923725_Chip-Seq_HPCs_Mouse0.97514986
111ERG_20517297_ChIP-Seq_VCAP_Human0.97309258
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96560652
113SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.96228328
114PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96095018
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95475888
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94678360
117* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.94475840
118TET1_21451524_ChIP-Seq_MESCs_Mouse0.94469623
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94010975
120SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92423238
121MYC_18555785_ChIP-Seq_MESCs_Mouse0.92287675
122PHF8_20622854_ChIP-Seq_HELA_Human0.91985896
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91579834
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90986309
125E2F1_21310950_ChIP-Seq_MCF-7_Human0.90262826
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89763716
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.89646814
128* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89084712
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88957157
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88940454
131CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88489249
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88347979
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.87926380
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87258816
135BCOR_27268052_Chip-Seq_Bcells_Human0.86097394
136* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85638662
137RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.85159901
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85106553
139MYC_19030024_ChIP-ChIP_MESCs_Mouse0.84810491
140CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84741662
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84472722
142SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84470367
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84004664
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83184322
145FLI1_21867929_ChIP-Seq_CD8_Mouse0.83125135
146KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82154660
147ELK3_25401928_ChIP-Seq_HUVEC_Human0.82061013
148SRY_22984422_ChIP-ChIP_TESTIS_Rat0.82055331
149ESET_19884257_ChIP-Seq_ESCs_Mouse0.81346436
150POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.81209471
151TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.81035117
152* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80670793
153* CTCF_26484167_Chip-Seq_Bcells_Mouse0.80608214
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80345625
155MYC_19079543_ChIP-ChIP_MESCs_Mouse0.79945514
156* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79796972
157TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79714350
158PCGF2_27294783_Chip-Seq_NPCs_Mouse0.79208944
159* SOX17_20123909_ChIP-Seq_XEN_Mouse0.78599102
160MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78307143
161GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78228550
162ATF3_27146783_Chip-Seq_COLON_Human0.77942625
163NCOR1_26117541_ChIP-Seq_K562_Human0.77779404
164SOX11_22085726_ChIP-Seq_ESNs_Mouse0.77415179
165RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76943565
166SOX2_16153702_ChIP-ChIP_HESCs_Human0.76118116
167CTCF_20526341_ChIP-Seq_ESCs_Human0.75743944
168CBP_20019798_ChIP-Seq_JUKART_Human0.75315298
169IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.75315298
170* TAL1_26923725_Chip-Seq_HPCs_Mouse0.74998196
171ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74952660
172SPI1_20517297_ChIP-Seq_HL60_Human0.74797398
173MYC_18940864_ChIP-ChIP_HL60_Human0.74320770
174MYB_26560356_Chip-Seq_TH1_Human0.74038687
175YY1_21170310_ChIP-Seq_MESCs_Mouse0.73948395
176NANOG_20526341_ChIP-Seq_ESCs_Human0.73920685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.27239201
2MP0001929_abnormal_gametogenesis5.20999963
3MP0008877_abnormal_DNA_methylation4.90790107
4MP0002210_abnormal_sex_determination3.62370526
5MP0001145_abnormal_male_reproductive3.05518374
6MP0002161_abnormal_fertility/fecundity3.02003712
7MP0010094_abnormal_chromosome_stability2.83287402
8MP0000653_abnormal_sex_gland2.69109661
9MP0003111_abnormal_nucleus_morphology2.61798965
10MP0002653_abnormal_ependyma_morphology2.54272479
11MP0003693_abnormal_embryo_hatching2.51497066
12MP0008057_abnormal_DNA_replication2.48798684
13MP0008058_abnormal_DNA_repair2.19041796
14MP0003077_abnormal_cell_cycle2.08444732
15MP0002877_abnormal_melanocyte_morpholog2.08415936
16MP0005410_abnormal_fertilization13.3512386
17MP0004185_abnormal_adipocyte_glucose1.88676330
18MP0002160_abnormal_reproductive_system1.87054265
19MP0004957_abnormal_blastocyst_morpholog1.86414918
20MP0005670_abnormal_white_adipose1.84749098
21MP0000537_abnormal_urethra_morphology1.77909085
22MP0003705_abnormal_hypodermis_morpholog1.77102488
23MP0008007_abnormal_cellular_replicative1.71772897
24MP0002009_preneoplasia1.66505750
25MP0001346_abnormal_lacrimal_gland1.61962684
26MP0003646_muscle_fatigue1.53401860
27MP0009697_abnormal_copulation1.52116770
28MP0001730_embryonic_growth_arrest1.44629176
29MP0010234_abnormal_vibrissa_follicle1.39753534
30MP0010307_abnormal_tumor_latency1.32358843
31MP0010030_abnormal_orbit_morphology1.28283090
32MP0005397_hematopoietic_system_phenotyp1.24040935
33MP0001545_abnormal_hematopoietic_system1.24040935
34MP0005501_abnormal_skin_physiology1.22874532
35MP0003890_abnormal_embryonic-extraembry1.21140012
36MP0002697_abnormal_eye_size1.16989658
37MP0003786_premature_aging1.15402094
38MP0001661_extended_life_span1.10385079
39MP0003937_abnormal_limbs/digits/tail_de1.09959696
40MP0005389_reproductive_system_phenotype1.09701823
41MP0004808_abnormal_hematopoietic_stem1.04727632
42MP0008932_abnormal_embryonic_tissue1.04104765
43MP0004233_abnormal_muscle_weight1.03702966
44MP0002282_abnormal_trachea_morphology1.03256847
45MP0002163_abnormal_gland_morphology1.02221541
46MP0000350_abnormal_cell_proliferation0.99695473
47MP0009278_abnormal_bone_marrow0.97279724
48MP0006035_abnormal_mitochondrial_morpho0.96657356
49MP0005380_embryogenesis_phenotype0.96590308
50MP0001672_abnormal_embryogenesis/_devel0.96590308
51MP0001697_abnormal_embryo_size0.95348719
52MP0005621_abnormal_cell_physiology0.95190221
53MP0009053_abnormal_anal_canal0.95087807
54MP0005623_abnormal_meninges_morphology0.94954594
55MP0002111_abnormal_tail_morphology0.93003052
56MP0000428_abnormal_craniofacial_morphol0.92598774
57MP0003566_abnormal_cell_adhesion0.91600657
58MP0002796_impaired_skin_barrier0.87959635
59MP0003221_abnormal_cardiomyocyte_apopto0.87952975
60MP0008995_early_reproductive_senescence0.87565507
61MP0000313_abnormal_cell_death0.87180970
62MP0001286_abnormal_eye_development0.86942096
63MP0002084_abnormal_developmental_patter0.86604800
64MP0000003_abnormal_adipose_tissue0.86466097
65MP0003941_abnormal_skin_development0.84616089
66MP0009703_decreased_birth_body0.82901186
67MP0003984_embryonic_growth_retardation0.82696314
68MP0002080_prenatal_lethality0.80948177
69MP0003699_abnormal_female_reproductive0.80940423
70MP0002085_abnormal_embryonic_tissue0.79715769
71MP0002088_abnormal_embryonic_growth/wei0.78893977
72MP0001119_abnormal_female_reproductive0.78769197
73MP0003115_abnormal_respiratory_system0.78086859
74MP0002166_altered_tumor_susceptibility0.77627155
75MP0000733_abnormal_muscle_development0.77519113
76MP0009333_abnormal_splenocyte_physiolog0.74900320
77MP0000358_abnormal_cell_content/0.74660976
78MP0002006_tumorigenesis0.74620405
79MP0005647_abnormal_sex_gland0.74402588
80MP0001293_anophthalmia0.74175154
81MP0000569_abnormal_digit_pigmentation0.73424396
82MP0003935_abnormal_craniofacial_develop0.71375821
83MP0002249_abnormal_larynx_morphology0.71246698
84MP0003942_abnormal_urinary_system0.70864699
85MP0003123_paternal_imprinting0.70037787
86MP0003385_abnormal_body_wall0.70010960
87MP0002019_abnormal_tumor_incidence0.68982830
88MP0000678_abnormal_parathyroid_gland0.66111925
89MP0001849_ear_inflammation0.65139635
90MP0003943_abnormal_hepatobiliary_system0.63836312
91MP0001348_abnormal_lacrimal_gland0.63763477
92MP0003718_maternal_effect0.63639049
93MP0006292_abnormal_olfactory_placode0.63507632
94MP0002086_abnormal_extraembryonic_tissu0.63296333
95MP0002396_abnormal_hematopoietic_system0.62985517
96MP0000627_abnormal_mammary_gland0.61707804
97MP0001881_abnormal_mammary_gland0.60885289
98MP0004197_abnormal_fetal_growth/weight/0.58707550
99MP0002098_abnormal_vibrissa_morphology0.58107193
100MP0001765_abnormal_ion_homeostasis0.57939414
101MP0003453_abnormal_keratinocyte_physiol0.57856488
102MP0002114_abnormal_axial_skeleton0.57700372
103MP0000049_abnormal_middle_ear0.57517915
104MP0000490_abnormal_crypts_of0.57287672
105MP0005666_abnormal_adipose_tissue0.53770538
106MP0002398_abnormal_bone_marrow0.52038896
107MP0000703_abnormal_thymus_morphology0.51723782
108MP0003878_abnormal_ear_physiology0.51175770
109MP0005377_hearing/vestibular/ear_phenot0.51175770
110MP0003787_abnormal_imprinting0.49830763
111MP0002405_respiratory_system_inflammati0.49781278
112MP0010352_gastrointestinal_tract_polyps0.48974864
113MP0002102_abnormal_ear_morphology0.47645942
114MP0005076_abnormal_cell_differentiation0.47460657
115MP0003763_abnormal_thymus_physiology0.44179566
116MP0009672_abnormal_birth_weight0.42403945
117MP0003315_abnormal_perineum_morphology0.42004840
118MP0000689_abnormal_spleen_morphology0.40963136
119MP0004264_abnormal_extraembryonic_tissu0.40047704
120MP0002234_abnormal_pharynx_morphology0.39416416
121MP0002092_abnormal_eye_morphology0.38695824
122MP0003950_abnormal_plasma_membrane0.38055957
123MP0006036_abnormal_mitochondrial_physio0.37577078
124MP0001727_abnormal_embryo_implantation0.37149739
125MP0002722_abnormal_immune_system0.36937494
126MP0003861_abnormal_nervous_system0.36312289
127MP0001915_intracranial_hemorrhage0.35768408
128MP0003121_genomic_imprinting0.33722052
129MP0005636_abnormal_mineral_homeostasis0.33228206
130MP0002928_abnormal_bile_duct0.32940321
131MP0002429_abnormal_blood_cell0.32702332
132MP0001764_abnormal_homeostasis0.31451761
133MP0002132_abnormal_respiratory_system0.31394325
134MP0002269_muscular_atrophy0.31080612
135MP0003011_delayed_dark_adaptation0.30995201
136MP0005451_abnormal_body_composition0.30492006
137MP0005384_cellular_phenotype0.30266237
138MP0009115_abnormal_fat_cell0.29919015
139MP0000432_abnormal_head_morphology0.28685902
140MP0004133_heterotaxia0.28665885
141MP0002169_no_abnormal_phenotype0.28368008
142MP0002873_normal_phenotype0.27857495
143MP0000858_altered_metastatic_potential0.27822990
144MP0005391_vision/eye_phenotype0.27645615
145MP0001919_abnormal_reproductive_system0.27316675

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.52565551
2Abnormal respiratory epithelium morphology (HP:0012253)8.40240287
3Abnormal respiratory motile cilium morphology (HP:0005938)8.40240287
4Rhinitis (HP:0012384)7.12291374
5Chronic bronchitis (HP:0004469)7.05976803
6Infertility (HP:0000789)6.59713735
7Nasal polyposis (HP:0100582)6.44039554
8Abnormal ciliary motility (HP:0012262)6.43522731
9Abnormality of the nasal mucosa (HP:0000433)5.21138502
10Male infertility (HP:0003251)4.72363623
11Bronchitis (HP:0012387)4.61373719
12Bronchiectasis (HP:0002110)4.46294148
13Nephronophthisis (HP:0000090)4.14397908
14Abnormal spermatogenesis (HP:0008669)3.92679169
15Impulsivity (HP:0100710)3.72645878
16Birth length less than 3rd percentile (HP:0003561)3.71515732
17Recurrent otitis media (HP:0000403)3.34537599
18Progressive muscle weakness (HP:0003323)3.30227283
19Increased nuchal translucency (HP:0010880)3.27172053
20Recurrent sinusitis (HP:0011108)3.19745351
21Abnormality of the renal medulla (HP:0100957)3.07354189
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.01900882
23Recurrent bronchitis (HP:0002837)2.98304996
24Reticulocytopenia (HP:0001896)2.98167773
25Gonadotropin excess (HP:0000837)2.76048717
26Cortical dysplasia (HP:0002539)2.72621254
27Multiple enchondromatosis (HP:0005701)2.71699264
28Progressive external ophthalmoplegia (HP:0000590)2.70991409
29Squamous cell carcinoma (HP:0002860)2.69682740
30Microvesicular hepatic steatosis (HP:0001414)2.69241142
31Hyperacusis (HP:0010780)2.67886699
32Proximal placement of thumb (HP:0009623)2.62079318
33Deviation of the thumb (HP:0009603)2.61095495
34Tubulointerstitial nephritis (HP:0001970)2.60205955
35Hypoplasia of the capital femoral epiphysis (HP:0003090)2.60018852
36Abnormality of midbrain morphology (HP:0002418)2.58584385
37Molar tooth sign on MRI (HP:0002419)2.58584385
38Myelodysplasia (HP:0002863)2.52451584
39Tubular atrophy (HP:0000092)2.50152501
40Azoospermia (HP:0000027)2.48861492
41Absent radius (HP:0003974)2.45775051
42Septate vagina (HP:0001153)2.42283800
43High anterior hairline (HP:0009890)2.40650747
44Abnormal umbilical cord blood vessels (HP:0011403)2.37475454
45Single umbilical artery (HP:0001195)2.37475454
46Abnormality of the fetal cardiovascular system (HP:0010948)2.37475454
47Breast hypoplasia (HP:0003187)2.33486797
48Abnormality of the lower motor neuron (HP:0002366)2.31667157
49Poikiloderma (HP:0001029)2.30112912
50Cafe-au-lait spot (HP:0000957)2.28014920
51Aplasia involving forearm bones (HP:0009822)2.25408687
52Absent forearm bone (HP:0003953)2.25408687
53Abnormality of the umbilical cord (HP:0010881)2.16962764
54Duplication of thumb phalanx (HP:0009942)2.13636219
55Tubulointerstitial abnormality (HP:0001969)2.13625251
56Trismus (HP:0000211)2.12942974
57Insomnia (HP:0100785)2.10942341
58Amyotrophic lateral sclerosis (HP:0007354)2.10933283
59Abnormal number of incisors (HP:0011064)2.10580477
60Horseshoe kidney (HP:0000085)2.09744365
61Deep philtrum (HP:0002002)2.09642261
62Short thumb (HP:0009778)2.07922727
63Heterotopia (HP:0002282)2.07390930
64Abnormality of chromosome segregation (HP:0002916)2.06729447
65Abnormal lung lobation (HP:0002101)2.05533590
66Abnormality of the phalanges of the hallux (HP:0010057)2.04425608
67Atresia of the external auditory canal (HP:0000413)2.04357766
68Abnormality of the duodenum (HP:0002246)2.03964125
69Ragged-red muscle fibers (HP:0003200)2.01250564
70Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3324619
71Absent/shortened dynein arms (HP:0200106)12.0526595
72Dynein arm defect of respiratory motile cilia (HP:0012255)12.0526595
73Absent epiphyses (HP:0010577)1.98003433
74Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.98003433
75Embryonal neoplasm (HP:0002898)1.96484949
76Premature ovarian failure (HP:0008209)1.94409436
77Choanal atresia (HP:0000453)1.92895684
78Degeneration of anterior horn cells (HP:0002398)1.92861174
79Abnormality of the anterior horn cell (HP:0006802)1.92861174
80Overlapping toe (HP:0001845)1.91560962
81Medial flaring of the eyebrow (HP:0010747)1.89272317
82Postaxial foot polydactyly (HP:0001830)1.89186947
83Abnormality of cells of the erythroid lineage (HP:0012130)1.88617725
84Supernumerary spleens (HP:0009799)1.88551129
85Entropion (HP:0000621)1.88009532
86Medulloblastoma (HP:0002885)1.87150508
87Abnormality of DNA repair (HP:0003254)1.86400838
88Urethral obstruction (HP:0000796)1.86149050
89Missing ribs (HP:0000921)1.85005592
90Overriding aorta (HP:0002623)1.83575938
91Abnormality of reticulocytes (HP:0004312)1.80867080
92Spastic diplegia (HP:0001264)1.80573846
93Short ribs (HP:0000773)1.80347082
94Arteriovenous malformation (HP:0100026)1.79809813
95Patellar aplasia (HP:0006443)1.79068326
96Aplasia/Hypoplasia of the patella (HP:0006498)1.77758576
97Long palpebral fissure (HP:0000637)1.77277205
98Sloping forehead (HP:0000340)1.77259218
99Triphalangeal thumb (HP:0001199)1.76057838
100Short middle phalanx of the 5th finger (HP:0004220)1.75896795
101Long eyelashes (HP:0000527)1.75633393
102Ulnar bowing (HP:0003031)1.74053959
103Spastic tetraparesis (HP:0001285)1.73394005
104Hypergonadotropic hypogonadism (HP:0000815)1.73332926
105Abnormal gallbladder physiology (HP:0012438)1.72103787
106Cholecystitis (HP:0001082)1.72103787
107Ureteral duplication (HP:0000073)1.71925050
108Abnormality of the distal phalanx of the thumb (HP:0009617)1.71740212
109Cutaneous melanoma (HP:0012056)1.71728563
110Dysmetric saccades (HP:0000641)1.69509783
111Elfin facies (HP:0004428)1.68690648
112Anal stenosis (HP:0002025)1.68120242
113Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67928029
114Sparse lateral eyebrow (HP:0005338)1.67841877
115Ectopic kidney (HP:0000086)1.67674272
116Facial cleft (HP:0002006)1.67010461
117Intestinal fistula (HP:0100819)1.66520507
118IgA deficiency (HP:0002720)1.65203927
119Oculomotor apraxia (HP:0000657)1.64898080
120Fibular hypoplasia (HP:0003038)1.64270886
121Sensory axonal neuropathy (HP:0003390)1.63857968
122Syringomyelia (HP:0003396)1.63033710
123Spinal cord lesions (HP:0100561)1.63033710
124Asymmetry of the thorax (HP:0001555)1.62885089
125Carpal bone hypoplasia (HP:0001498)1.61441652
126Tubulointerstitial fibrosis (HP:0005576)1.61002000
127Prominent nose (HP:0000448)1.60898381
128Ankyloglossia (HP:0010296)1.60621133
129Duplicated collecting system (HP:0000081)1.60317544
130Capillary hemangiomas (HP:0005306)1.59256608
131Neoplasm of the adrenal cortex (HP:0100641)1.59086747
132Congenital hepatic fibrosis (HP:0002612)1.58783762
133Aplasia/Hypoplasia of the uvula (HP:0010293)1.58279213
134Selective tooth agenesis (HP:0001592)1.57017333
135Abnormality of chromosome stability (HP:0003220)1.55629203
136Impaired proprioception (HP:0010831)1.55525893
137Stage 5 chronic kidney disease (HP:0003774)1.54086984
138Abnormality of the preputium (HP:0100587)1.54049004
139Dyschromatopsia (HP:0007641)1.53940863
140Meckel diverticulum (HP:0002245)1.51842579
141Abnormality of the renal cortex (HP:0011035)1.49629741
142Microglossia (HP:0000171)1.47893417
143Renal dysplasia (HP:0000110)1.46080826
144Abnormality of the ileum (HP:0001549)1.45778615
145Personality changes (HP:0000751)1.44966553
146Absent frontal sinuses (HP:0002688)1.43478241
14711 pairs of ribs (HP:0000878)1.40974944
148Abnormal drinking behavior (HP:0030082)1.39930015
149Polydipsia (HP:0001959)1.39930015
150Chromsome breakage (HP:0040012)1.39442489
151Broad distal phalanx of finger (HP:0009836)1.39008058
152Abnormal biliary tract physiology (HP:0012439)1.38873420
153Bile duct proliferation (HP:0001408)1.38873420
154Cleft eyelid (HP:0000625)1.38653051
155Cystic liver disease (HP:0006706)1.37894092
156Chromosomal breakage induced by crosslinking agents (HP:0003221)1.37342550
157Choroideremia (HP:0001139)1.35177975
158Duodenal stenosis (HP:0100867)1.34530380
159Small intestinal stenosis (HP:0012848)1.34530380
160Short femoral neck (HP:0100864)1.33589098
161High pitched voice (HP:0001620)1.32842508
162Truncal obesity (HP:0001956)1.32618669
163Deformed sella turcica (HP:0002681)1.32428687
164Nephroblastoma (Wilms tumor) (HP:0002667)1.31821288
165Abnormality of abdominal situs (HP:0011620)1.31257797
166Abdominal situs inversus (HP:0003363)1.31257797
167Pancreatic fibrosis (HP:0100732)1.29999656
168Upper motor neuron abnormality (HP:0002127)1.29990737
169Postaxial hand polydactyly (HP:0001162)1.29438851
170Cerebellar dysplasia (HP:0007033)1.27390867
171Median cleft lip (HP:0000161)1.26293560
172Chronic sinusitis (HP:0011109)1.24076538
173Hemorrhage of the eye (HP:0011885)1.23752158
174Abnormality of the dental root (HP:0006486)1.23211847
175Taurodontia (HP:0000679)1.23211847
176Abnormality of permanent molar morphology (HP:0011071)1.23211847
177Aplasia/Hypoplasia of the tongue (HP:0010295)1.23127277
178Abnormality of the carotid arteries (HP:0005344)1.22932222
179Abnormality of renal excretion (HP:0011036)1.21286080
180Embryonal renal neoplasm (HP:0011794)1.20838279
181Absent thumb (HP:0009777)1.20413858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.41110482
2PDK47.41110482
3TESK15.56659684
4PDK24.65281773
5PRKD34.64528579
6ICK3.86887402
7SMG13.31471295
8NEK23.18381518
9CDC72.33693623
10ZAK2.15968193
11PBK2.03190684
12PTK2B1.78943616
13NME21.77880911
14TSSK61.77766737
15SCYL21.77211184
16TTK1.73693924
17WEE11.73603037
18PNCK1.71445905
19VRK21.62744807
20STK381.54448202
21PRPF4B1.54000294
22BUB11.49737119
23TAF11.49240758
24BRD41.48988006
25EEF2K1.46175707
26IRAK31.45679130
27WNK41.39892871
28DYRK31.38339609
29CDK121.37737571
30STK391.27848346
31CHEK21.27577177
32STK31.25485542
33TESK21.22931923
34PLK41.21726336
35DYRK1B1.17236141
36CCNB11.12145630
37PASK1.10180793
38ATR0.98105629
39PLK10.97811316
40CHEK10.93597783
41BRSK20.91081050
42MKNK10.87969392
43CAMK1D0.84034004
44PDK10.82984314
45ERBB40.79795175
46EIF2AK30.75747508
47STK100.75598642
48STK38L0.74724052
49MKNK20.74440416
50KDR0.73530345
51EPHA20.72063221
52TYRO30.71810504
53MST1R0.71696421
54MAPK110.70627611
55EIF2AK20.68767589
56AURKB0.68073291
57CDK40.66618129
58ATM0.66454260
59MAP3K90.65154787
60STK160.64632136
61EIF2AK10.63489007
62SRPK10.63021057
63AKT20.62319859
64ALK0.62011916
65BRSK10.61229389
66ARAF0.61176000
67TAOK20.59802671
68RPS6KA50.59203743
69RAF10.58264560
70PAK10.57741982
71CDK70.56236827
72PAK40.54484658
73MAP3K100.52599559
74MTOR0.47453973
75TAOK10.47343259
76MST40.45269819
77PIM10.44296197
78PRKCI0.44048892
79AURKA0.43984379
80PIM20.42811825
81ACVR1B0.41118858
82LATS10.40954610
83MAPK150.40894714
84KSR20.40736842
85CDK20.40546678
86WNK10.40118568
87MAP3K80.39219556
88TTN0.39195560
89RPS6KA40.38313680
90STK40.37821083
91BRAF0.37730204
92MAP4K10.37157394
93CDK60.34668998
94MET0.34022513
95PDPK10.32677967
96PAK20.32312296
97PKN20.31871673
98SIK10.31796290
99CDK10.29558722
100PDGFRA0.29269230
101CDK140.28724217
102PLK30.27312593
103MAPKAPK30.26782590
104LATS20.26633114
105MARK30.26506085
106VRK10.26014929
107MAP2K60.25723736
108PINK10.25068420
109CAMK1G0.23311278
110CSNK2A10.22225946
111CLK10.19626034
112PRKAA10.19570613
113IRAK10.18834258
114ZAP700.18772569
115CSNK2A20.18187868
116NEK10.17614014
117CSF1R0.17503029
118TLK10.16522533
119MELK0.15938577
120MARK20.15924451
121MAP3K50.14977357
122RPS6KB20.14681455
123RPS6KB10.13718139
124MUSK0.13445142
125RPS6KA10.11956640
126GSK3B0.10634009
127CSNK1D0.09512864
128MAP3K60.08739271
129TRIB30.07604871
130CDK11A0.06494532
131PRKDC0.06158471
132CDK150.05654916
133MAPKAPK50.05611045
134RIPK40.04840765
135MAPK140.03444515
136CDK80.03440740
137CDK90.03339472
138MAPK10.02466284
139CDK180.01862847

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.79954678
2Basal transcription factors_Homo sapiens_hsa030223.59048284
3DNA replication_Homo sapiens_hsa030303.33103615
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.26295009
5Fanconi anemia pathway_Homo sapiens_hsa034603.07194183
6RNA transport_Homo sapiens_hsa030132.95723181
7Fatty acid biosynthesis_Homo sapiens_hsa000612.75232442
8Pyruvate metabolism_Homo sapiens_hsa006202.44767274
9Mismatch repair_Homo sapiens_hsa034302.41176281
10Cell cycle_Homo sapiens_hsa041102.32402064
11Homologous recombination_Homo sapiens_hsa034402.28286133
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.20434244
13Linoleic acid metabolism_Homo sapiens_hsa005912.16405262
14mRNA surveillance pathway_Homo sapiens_hsa030152.15593898
15Oocyte meiosis_Homo sapiens_hsa041142.09849446
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07327626
17Selenocompound metabolism_Homo sapiens_hsa004502.05926627
18Base excision repair_Homo sapiens_hsa034102.04549945
19Pentose phosphate pathway_Homo sapiens_hsa000302.00880384
20Spliceosome_Homo sapiens_hsa030401.90267990
21Glucagon signaling pathway_Homo sapiens_hsa049221.83468505
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.73620905
23Pyrimidine metabolism_Homo sapiens_hsa002401.72564593
24RNA degradation_Homo sapiens_hsa030181.65216198
25Nucleotide excision repair_Homo sapiens_hsa034201.65125876
26Antigen processing and presentation_Homo sapiens_hsa046121.65065968
27Ribosome_Homo sapiens_hsa030101.62352617
28Purine metabolism_Homo sapiens_hsa002301.49756994
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48725984
30Non-homologous end-joining_Homo sapiens_hsa034501.46714586
31Systemic lupus erythematosus_Homo sapiens_hsa053221.46613282
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.43919006
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.41275825
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40399707
35Dorso-ventral axis formation_Homo sapiens_hsa043201.38604548
36Thyroid cancer_Homo sapiens_hsa052161.34682227
37Propanoate metabolism_Homo sapiens_hsa006401.34596848
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31857752
39Chronic myeloid leukemia_Homo sapiens_hsa052201.26114964
40Bladder cancer_Homo sapiens_hsa052191.23064835
41Glycerolipid metabolism_Homo sapiens_hsa005611.23043912
42MicroRNAs in cancer_Homo sapiens_hsa052061.22417113
43Fructose and mannose metabolism_Homo sapiens_hsa000511.19638376
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16937445
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.16602664
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11138668
47Proteasome_Homo sapiens_hsa030501.10182880
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05694379
49Non-small cell lung cancer_Homo sapiens_hsa052231.01086177
50p53 signaling pathway_Homo sapiens_hsa041151.00048951
51Carbon metabolism_Homo sapiens_hsa012000.98886947
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98252682
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97483632
54Lysine degradation_Homo sapiens_hsa003100.96866954
55Biosynthesis of amino acids_Homo sapiens_hsa012300.94554698
56Pancreatic cancer_Homo sapiens_hsa052120.93506179
57RNA polymerase_Homo sapiens_hsa030200.92809527
58Viral carcinogenesis_Homo sapiens_hsa052030.92752064
59Prostate cancer_Homo sapiens_hsa052150.86759063
60Epstein-Barr virus infection_Homo sapiens_hsa051690.84077039
61Ether lipid metabolism_Homo sapiens_hsa005650.82709309
62Folate biosynthesis_Homo sapiens_hsa007900.82536853
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81546854
64Colorectal cancer_Homo sapiens_hsa052100.80285923
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.80260828
66Glutathione metabolism_Homo sapiens_hsa004800.79296962
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75996545
68Legionellosis_Homo sapiens_hsa051340.74688412
69Huntingtons disease_Homo sapiens_hsa050160.73713795
70Apoptosis_Homo sapiens_hsa042100.73482137
71Herpes simplex infection_Homo sapiens_hsa051680.71752965
72Fat digestion and absorption_Homo sapiens_hsa049750.70381869
73Adherens junction_Homo sapiens_hsa045200.68404200
74PPAR signaling pathway_Homo sapiens_hsa033200.68055740
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.66784479
76Hepatitis B_Homo sapiens_hsa051610.66199284
77Hippo signaling pathway_Homo sapiens_hsa043900.66143764
78Endometrial cancer_Homo sapiens_hsa052130.65706632
79Mineral absorption_Homo sapiens_hsa049780.61581429
80Acute myeloid leukemia_Homo sapiens_hsa052210.61121607
81One carbon pool by folate_Homo sapiens_hsa006700.58546856
82Alcoholism_Homo sapiens_hsa050340.56072699
83Melanoma_Homo sapiens_hsa052180.55867726
84Hedgehog signaling pathway_Homo sapiens_hsa043400.55817269
85Glioma_Homo sapiens_hsa052140.55486132
86HTLV-I infection_Homo sapiens_hsa051660.53711826
87Arachidonic acid metabolism_Homo sapiens_hsa005900.51622499
88TGF-beta signaling pathway_Homo sapiens_hsa043500.51486686
89VEGF signaling pathway_Homo sapiens_hsa043700.51403663
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50124851
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49146608
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48965571
93B cell receptor signaling pathway_Homo sapiens_hsa046620.47569041
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47503579
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45393898
96Amphetamine addiction_Homo sapiens_hsa050310.44688869
97Measles_Homo sapiens_hsa051620.43255663
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42739026
99N-Glycan biosynthesis_Homo sapiens_hsa005100.41569718
100Renin-angiotensin system_Homo sapiens_hsa046140.41163332
101Galactose metabolism_Homo sapiens_hsa000520.39786844
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39565364
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39016147
104AMPK signaling pathway_Homo sapiens_hsa041520.37440117
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37379598
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37232927
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.36697192
108Influenza A_Homo sapiens_hsa051640.36619174
109Estrogen signaling pathway_Homo sapiens_hsa049150.36519679
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35404245
111Proteoglycans in cancer_Homo sapiens_hsa052050.34040603
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33852685
113mTOR signaling pathway_Homo sapiens_hsa041500.32849610
114Renal cell carcinoma_Homo sapiens_hsa052110.31672133
115Insulin signaling pathway_Homo sapiens_hsa049100.30701367
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.30273489
117HIF-1 signaling pathway_Homo sapiens_hsa040660.30001586
118ErbB signaling pathway_Homo sapiens_hsa040120.29441138
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29045923
120Endocytosis_Homo sapiens_hsa041440.28162757
121Pathways in cancer_Homo sapiens_hsa052000.27710942
122Inositol phosphate metabolism_Homo sapiens_hsa005620.27163572
123Notch signaling pathway_Homo sapiens_hsa043300.26286261
124Small cell lung cancer_Homo sapiens_hsa052220.25427775
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24637944
126Fatty acid metabolism_Homo sapiens_hsa012120.22890746
127Fatty acid degradation_Homo sapiens_hsa000710.21967171
128Basal cell carcinoma_Homo sapiens_hsa052170.21013413
129Metabolic pathways_Homo sapiens_hsa011000.20755055
130T cell receptor signaling pathway_Homo sapiens_hsa046600.20007670
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18934077
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.18880320
133Cardiac muscle contraction_Homo sapiens_hsa042600.18809546
134Shigellosis_Homo sapiens_hsa051310.18398385
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18091109
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.17659179
137Wnt signaling pathway_Homo sapiens_hsa043100.16875048
138Sulfur relay system_Homo sapiens_hsa041220.16380081
139Toxoplasmosis_Homo sapiens_hsa051450.16348508
140Thyroid hormone synthesis_Homo sapiens_hsa049180.11556219
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.10939747
142Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.10481602
143Primary immunodeficiency_Homo sapiens_hsa053400.10310618
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10294890

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