GSK3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.50327428
2locomotory exploration behavior (GO:0035641)5.21947832
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.65423321
4sodium ion export (GO:0071436)4.63040560
5negative regulation of erythrocyte differentiation (GO:0045647)4.55417271
6layer formation in cerebral cortex (GO:0021819)4.39184797
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.29945543
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.10159554
9cytoskeletal anchoring at plasma membrane (GO:0007016)4.05348732
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.01149483
11glutamate secretion (GO:0014047)3.87937610
12regulation of ARF protein signal transduction (GO:0032012)3.68138860
13vocalization behavior (GO:0071625)3.67331631
14activation of protein kinase A activity (GO:0034199)3.66285691
15cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.64650139
16regulation of synapse structural plasticity (GO:0051823)3.62010734
17positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.58585291
18cellular potassium ion homeostasis (GO:0030007)3.57420677
19synaptic vesicle exocytosis (GO:0016079)3.51474263
20regulation of ARF GTPase activity (GO:0032312)3.49120527
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.47062154
22regulation of synaptic vesicle exocytosis (GO:2000300)3.46384788
23regulation of mammary gland epithelial cell proliferation (GO:0033599)3.45808681
24regulation of clathrin-mediated endocytosis (GO:2000369)3.45438209
25regulation of glutamate receptor signaling pathway (GO:1900449)3.42250370
26activation of Rac GTPase activity (GO:0032863)3.37615901
27cell communication by electrical coupling (GO:0010644)3.37422923
28G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.37345151
29exploration behavior (GO:0035640)3.36922077
30proline transport (GO:0015824)3.30719928
31activation of MAPKKK activity (GO:0000185)3.30080471
32neuromuscular process controlling balance (GO:0050885)3.29344730
33neurotransmitter secretion (GO:0007269)3.29183443
34regulation of neuronal synaptic plasticity (GO:0048168)3.20845245
35cell-cell junction maintenance (GO:0045217)3.19437356
36positive regulation of protein dephosphorylation (GO:0035307)3.18809331
37protein localization to endosome (GO:0036010)3.16840219
38dendritic spine morphogenesis (GO:0060997)3.14163435
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.13577094
40negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.12006756
41stress fiber assembly (GO:0043149)3.11838574
42modulation by virus of host process (GO:0019054)3.11739035
43negative regulation of cell size (GO:0045792)3.11070552
44modulation by symbiont of host cellular process (GO:0044068)3.10113715
45cerebellar granule cell differentiation (GO:0021707)3.08403323
46regulation of synaptic vesicle transport (GO:1902803)3.05937199
47apoptotic process involved in morphogenesis (GO:0060561)3.03850924
48glycine transport (GO:0015816)3.03137710
49signal complex assembly (GO:0007172)3.02071617
50mannose metabolic process (GO:0006013)3.01549845
51positive regulation of histone deacetylation (GO:0031065)2.98758079
52* positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.96428392
53cerebellar Purkinje cell layer development (GO:0021680)2.96270353
54response to parathyroid hormone (GO:0071107)2.94449745
55regulation of early endosome to late endosome transport (GO:2000641)2.92356503
56establishment of nucleus localization (GO:0040023)2.90889689
57protein targeting to plasma membrane (GO:0072661)2.90687449
58potassium ion import (GO:0010107)2.90190516
59positive regulation of synapse maturation (GO:0090129)2.88207195
603-UTR-mediated mRNA stabilization (GO:0070935)2.87693501
61positive regulation of fibroblast migration (GO:0010763)2.87545643
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.87210795
63intracellular estrogen receptor signaling pathway (GO:0030520)2.87182264
64gamma-aminobutyric acid transport (GO:0015812)2.84414125
65positive regulation by symbiont of host defense response (GO:0052509)2.83738204
66modulation by symbiont of host defense response (GO:0052031)2.83738204
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.83738204
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.83738204
69positive regulation by organism of defense response of other organism involved in symbiotic interact2.83738204
70modulation by symbiont of host immune response (GO:0052553)2.83738204
71peptidyl-lysine dimethylation (GO:0018027)2.81369250
72plasma membrane repair (GO:0001778)2.80363903
73regulation of NFAT protein import into nucleus (GO:0051532)2.79794807
74protein retention in ER lumen (GO:0006621)2.77958581
75regulation of chromatin binding (GO:0035561)2.77666863
76cellular sodium ion homeostasis (GO:0006883)2.73370619
77dopamine receptor signaling pathway (GO:0007212)2.70945766
78regulation of protein dephosphorylation (GO:0035304)2.68779788
79negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.68386736
80adherens junction assembly (GO:0034333)2.67241381
81peptidyl-tyrosine autophosphorylation (GO:0038083)2.66993081
82clathrin coat assembly (GO:0048268)2.66347650
83cell communication involved in cardiac conduction (GO:0086065)2.65304340
84regulation of dendritic spine morphogenesis (GO:0061001)2.65036811
85cell migration in hindbrain (GO:0021535)2.64845198
86positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.64238878
87regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.64238878
88alanine transport (GO:0032328)2.64060293
89maternal placenta development (GO:0001893)2.63120381
90positive regulation of Rap GTPase activity (GO:0032854)2.62547753
91negative regulation of potassium ion transmembrane transport (GO:1901380)2.61828604
92barbed-end actin filament capping (GO:0051016)2.58053238
93semaphorin-plexin signaling pathway (GO:0071526)2.58034328
94dendrite morphogenesis (GO:0048813)2.56132513
95modulation by virus of host morphology or physiology (GO:0019048)2.55281399
96negative regulation of cell killing (GO:0031342)2.54327693
97negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.54327693
98long-term memory (GO:0007616)2.54251532
99maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.53935538
100prepulse inhibition (GO:0060134)2.53350713
101cerebellar Purkinje cell differentiation (GO:0021702)2.53188083
102vesicle transport along microtubule (GO:0047496)2.52673224
103membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.52520677
104regulation of synapse maturation (GO:0090128)2.52384664
105nerve growth factor signaling pathway (GO:0038180)2.51442923
106positive regulation of Cdc42 GTPase activity (GO:0043089)2.50586721
107regulation of defense response to virus by virus (GO:0050690)2.50378210
108pre-miRNA processing (GO:0031054)2.49721023
109adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.48583831
110synaptic vesicle endocytosis (GO:0048488)2.48361389
111peptidyl-threonine phosphorylation (GO:0018107)2.48265213
112response to peptidoglycan (GO:0032494)2.47740023
113glucose 6-phosphate metabolic process (GO:0051156)2.47714258
114dicarboxylic acid biosynthetic process (GO:0043650)2.46389222
115regulation of translational termination (GO:0006449)2.45937159
116planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45821588
117ionotropic glutamate receptor signaling pathway (GO:0035235)2.45795826
118regulation of Rap GTPase activity (GO:0032317)2.45281770
119protein localization to synapse (GO:0035418)2.44103686
120focal adhesion assembly (GO:0048041)2.43672898
121cell-substrate adherens junction assembly (GO:0007045)2.43672898
122amino acid import (GO:0043090)2.42714475
123regulation of synaptic plasticity (GO:0048167)2.41740885
124neurotransmitter-gated ion channel clustering (GO:0072578)2.39120975
125regulation of regulated secretory pathway (GO:1903305)2.39078383
126glial cell proliferation (GO:0014009)2.38832063
127membrane repolarization (GO:0086009)2.38670340
128peptidyl-threonine modification (GO:0018210)2.38198074
129cellular response to catecholamine stimulus (GO:0071870)2.37965277
130cellular response to monoamine stimulus (GO:0071868)2.37965277
131negative regulation of toll-like receptor signaling pathway (GO:0034122)2.37748390
132cortical actin cytoskeleton organization (GO:0030866)2.37461966
133actin filament bundle assembly (GO:0051017)2.37351706
134actin filament bundle organization (GO:0061572)2.37351706
135mating behavior (GO:0007617)2.35541192
136membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.34606218
137regulation of cholesterol homeostasis (GO:2000188)2.34549030
138response to laminar fluid shear stress (GO:0034616)2.33479427
139activation of JUN kinase activity (GO:0007257)2.33478410
140potassium ion homeostasis (GO:0055075)2.33151590
141L-amino acid import (GO:0043092)2.32846024
142neuromuscular process controlling posture (GO:0050884)2.31733249
143regulation of excitatory postsynaptic membrane potential (GO:0060079)2.29508139
144response to acidic pH (GO:0010447)2.29082457
145neurotransmitter transport (GO:0006836)2.28790975
146negative regulation of organelle assembly (GO:1902116)2.28600931
147regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.28058774
148regulation of leukocyte degranulation (GO:0043300)2.27564778
149positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.26164750
150macrophage activation involved in immune response (GO:0002281)2.26101012
151cellular response to nerve growth factor stimulus (GO:1990090)2.26029121
152response to nerve growth factor (GO:1990089)2.26029121
153retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.25236947
154positive regulation of membrane potential (GO:0045838)2.25035392
155positive regulation of myotube differentiation (GO:0010831)2.24273421
156neuronal ion channel clustering (GO:0045161)2.23672709
157negative regulation of microtubule polymerization (GO:0031115)2.23107761
158NLS-bearing protein import into nucleus (GO:0006607)2.23054149
159neuromuscular process (GO:0050905)2.23017294
160regulation of neurotransmitter levels (GO:0001505)2.21045151
161positive regulation of sodium ion transport (GO:0010765)2.20843357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.14694846
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.83575632
3KDM2B_26808549_Chip-Seq_SUP-B15_Human2.69292759
4KDM2B_26808549_Chip-Seq_DND41_Human2.62563042
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.52306516
6ZFP281_18757296_ChIP-ChIP_E14_Mouse2.49208463
7MYC_22102868_ChIP-Seq_BL_Human2.45661826
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.40979104
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.40207809
10KDM2B_26808549_Chip-Seq_K562_Human2.38101300
11EZH2_22144423_ChIP-Seq_EOC_Human2.33171476
12LXR_22292898_ChIP-Seq_THP-1_Human2.32148901
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.15763805
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.13128728
15TCF7_22412390_ChIP-Seq_EML_Mouse2.10353366
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10207203
17DROSHA_22980978_ChIP-Seq_HELA_Human2.09642572
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.09352326
19ZFP281_27345836_Chip-Seq_ESCs_Mouse2.07882224
20* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.00982957
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97791205
22KDM2B_26808549_Chip-Seq_JURKAT_Human1.95634517
23ZNF263_19887448_ChIP-Seq_K562_Human1.94274320
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.93790233
25DNAJC2_21179169_ChIP-ChIP_NT2_Human1.90333654
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88891529
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86966482
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75814834
29GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.73180009
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.70265491
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.70140741
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70054528
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.68043106
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.67637492
35SRY_22984422_ChIP-ChIP_TESTIS_Rat1.64537560
36* ELK3_25401928_ChIP-Seq_HUVEC_Human1.63194241
37* RACK7_27058665_Chip-Seq_MCF-7_Human1.62441734
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60564900
39* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59405544
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58865053
41* CREB1_26743006_Chip-Seq_LNCaP_Human1.54808677
42* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54422269
43VDR_21846776_ChIP-Seq_THP-1_Human1.53618062
44VDR_24763502_ChIP-Seq_THP-1_Human1.53309509
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51371961
46CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41672586
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.37526132
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36721715
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36721715
50REST_21632747_ChIP-Seq_MESCs_Mouse1.36702161
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36068157
52TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.35501042
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.35036935
54SMC4_20622854_ChIP-Seq_HELA_Human1.34460060
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33970979
56GATA1_19941826_ChIP-Seq_K562_Human1.33441843
57SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33292230
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31829216
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29657929
60P68_20966046_ChIP-Seq_HELA_Human1.29207288
61MAF_26560356_Chip-Seq_TH2_Human1.28675979
62* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26842704
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26829411
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26159051
65* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24836699
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23959994
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22386228
68* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22131844
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21118231
70* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20884255
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20555079
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20364394
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.19526373
74BCOR_27268052_Chip-Seq_Bcells_Human1.19317886
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19114295
76ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19096899
77CTCF_27219007_Chip-Seq_Bcells_Human1.18864509
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17947847
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17102089
80MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17060438
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16906285
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14861288
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14709308
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13740901
85SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13015247
86* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12265745
87JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11979421
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.10787247
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10270962
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.10268991
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.09189882
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08826488
93* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08519295
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08411439
95UTX_26944678_Chip-Seq_JUKART_Human1.07451815
96* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07446099
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06906330
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06454948
99ATF3_27146783_Chip-Seq_COLON_Human1.06244995
100EZH2_27294783_Chip-Seq_ESCs_Mouse1.06127865
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05820526
102JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05757499
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05584208
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05159463
105* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05152834
106SA1_27219007_Chip-Seq_Bcells_Human1.05131926
107* MAF_26560356_Chip-Seq_TH1_Human1.04817487
108OCT4_19829295_ChIP-Seq_ESCs_Human1.03932886
109SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.03243366
110SPI1_23127762_ChIP-Seq_K562_Human1.03094695
111BCL6_27268052_Chip-Seq_Bcells_Human1.02897837
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.01659109
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.01386813
114TET1_21490601_ChIP-Seq_MESCs_Mouse1.01325070
115SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01288856
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01061462
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00536014
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00192319
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00013776
120ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99689667
121STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.99574193
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99352569
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97274336
124RING1B_27294783_Chip-Seq_ESCs_Mouse0.96404048
125SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95735450
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95645475
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95242140
128NCOR1_26117541_ChIP-Seq_K562_Human0.95005654
129* ETS1_21867929_ChIP-Seq_TH2_Mouse0.94122877
130* TP63_22573176_ChIP-Seq_HFKS_Human0.93976500
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.93881372
132KLF4_19829295_ChIP-Seq_ESCs_Human0.93500187
133* TBX20_22328084_ChIP-Seq_HEART_Mouse0.91245372
134* TBX20_22080862_ChIP-Seq_HEART_Mouse0.91245372
135CLOCK_20551151_ChIP-Seq_293T_Human0.90648784
136TP53_22127205_ChIP-Seq_IMR90_Human0.90304631
137FOXA2_19822575_ChIP-Seq_HepG2_Human0.90286073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.49925665
2MP0003705_abnormal_hypodermis_morpholog3.32314638
3MP0003635_abnormal_synaptic_transmissio3.18147431
4MP0005451_abnormal_body_composition2.91937033
5MP0008961_abnormal_basal_metabolism2.80367828
6MP0004858_abnormal_nervous_system2.61661039
7MP0002822_catalepsy2.57959045
8MP0003123_paternal_imprinting2.52319752
9MP0004270_analgesia2.50508525
10MP0010234_abnormal_vibrissa_follicle2.47725551
11MP0002063_abnormal_learning/memory/cond2.42695517
12MP0009780_abnormal_chondrocyte_physiolo2.41134428
13MP0005409_darkened_coat_color2.31667767
14MP0003303_peritoneal_inflammation2.31326118
15MP0002909_abnormal_adrenal_gland2.24695142
16MP0005058_abnormal_lysosome_morphology2.18455696
17MP0003300_gastrointestinal_ulcer2.09776312
18MP0005076_abnormal_cell_differentiation2.08907897
19MP0003436_decreased_susceptibility_to2.08661364
20MP0000678_abnormal_parathyroid_gland2.07322949
21MP0003329_amyloid_beta_deposits2.05250158
22MP0002064_seizures2.03500441
23MP0009745_abnormal_behavioral_response1.98847991
24MP0004130_abnormal_muscle_cell1.96594044
25MP0008260_abnormal_autophagy1.90110870
26MP0003283_abnormal_digestive_organ1.88025742
27MP0000751_myopathy1.85547491
28MP0002249_abnormal_larynx_morphology1.77671254
29MP0008569_lethality_at_weaning1.75447793
30MP0004233_abnormal_muscle_weight1.69666179
31MP0004811_abnormal_neuron_physiology1.67622743
32MP0004885_abnormal_endolymph1.64649010
33MP0003075_altered_response_to1.63831765
34MP0004510_myositis1.62604280
35MP0003453_abnormal_keratinocyte_physiol1.62463487
36MP0004185_abnormal_adipocyte_glucose1.60132748
37MP0009046_muscle_twitch1.57348354
38MP0005623_abnormal_meninges_morphology1.54654908
39MP0010352_gastrointestinal_tract_polyps1.54052466
40MP0002572_abnormal_emotion/affect_behav1.53697001
41MP0001849_ear_inflammation1.43524803
42MP0005167_abnormal_blood-brain_barrier1.41883156
43MP0004947_skin_inflammation1.37329212
44MP0004087_abnormal_muscle_fiber1.37018815
45MP0000747_muscle_weakness1.34070766
46MP0009278_abnormal_bone_marrow1.31447736
47MP0003880_abnormal_central_pattern1.26400588
48MP0005423_abnormal_somatic_nervous1.23490595
49MP0003633_abnormal_nervous_system1.23318338
50MP0000858_altered_metastatic_potential1.22749558
51MP0002733_abnormal_thermal_nociception1.21141947
52MP0003879_abnormal_hair_cell1.21075096
53MP0003634_abnormal_glial_cell1.19658434
54MP0008874_decreased_physiological_sensi1.18450829
55MP0000003_abnormal_adipose_tissue1.17400803
56MP0001968_abnormal_touch/_nociception1.17322008
57MP0002734_abnormal_mechanical_nocicepti1.17246745
58MP0001501_abnormal_sleep_pattern1.15693697
59MP0001486_abnormal_startle_reflex1.14465297
60MP0003172_abnormal_lysosome_physiology1.14065210
61MP0000955_abnormal_spinal_cord1.13435733
62MP0000604_amyloidosis1.13102498
63MP0000920_abnormal_myelination1.13067825
64MP0005375_adipose_tissue_phenotype1.10855130
65MP0001440_abnormal_grooming_behavior1.10529855
66MP0002269_muscular_atrophy1.10057194
67MP0009333_abnormal_splenocyte_physiolog1.09465441
68MP0002837_dystrophic_cardiac_calcinosis1.08049955
69MP0000681_abnormal_thyroid_gland1.07095195
70MP0001346_abnormal_lacrimal_gland1.06091902
71MP0002272_abnormal_nervous_system1.03982400
72MP0005666_abnormal_adipose_tissue1.03401418
73MP0002796_impaired_skin_barrier1.03285463
74MP0002089_abnormal_postnatal_growth/wei1.02640014
75MP0001970_abnormal_pain_threshold1.00609721
76MP0008770_decreased_survivor_rate0.99617573
77MP0002653_abnormal_ependyma_morphology0.98121192
78MP0000750_abnormal_muscle_regeneration0.97879180
79MP0003045_fibrosis0.97717108
80MP0002877_abnormal_melanocyte_morpholog0.97320978
81MP0004145_abnormal_muscle_electrophysio0.95527046
82MP0002066_abnormal_motor_capabilities/c0.94965616
83MP0010630_abnormal_cardiac_muscle0.93937764
84MP0003566_abnormal_cell_adhesion0.92729428
85MP0004924_abnormal_behavior0.92714204
86MP0005386_behavior/neurological_phenoty0.92714204
87MP0001348_abnormal_lacrimal_gland0.92208699
88MP0000569_abnormal_digit_pigmentation0.90603536
89MP0000759_abnormal_skeletal_muscle0.89646024
90MP0005187_abnormal_penis_morphology0.88677367
91MP0003631_nervous_system_phenotype0.88393882
92MP0005501_abnormal_skin_physiology0.86758335
93MP0000733_abnormal_muscle_development0.86539645
94MP0000537_abnormal_urethra_morphology0.86533502
95MP0003183_abnormal_peptide_metabolism0.84349906
96MP0002152_abnormal_brain_morphology0.84038215
97MP0002998_abnormal_bone_remodeling0.83598946
98MP0005025_abnormal_response_to0.83412770
99MP0004085_abnormal_heartbeat0.83085388
100MP0004084_abnormal_cardiac_muscle0.81990691
101MP0005166_decreased_susceptibility_to0.81927565
102MP0002419_abnormal_innate_immunity0.81720536
103MP0009379_abnormal_foot_pigmentation0.81677242
104MP0009840_abnormal_foam_cell0.80561548
105MP0000013_abnormal_adipose_tissue0.80397385
106MP0003646_muscle_fatigue0.79193165
107MP0008872_abnormal_physiological_respon0.78685448
108MP0001533_abnormal_skeleton_physiology0.78266738
109MP0003656_abnormal_erythrocyte_physiolo0.78221688
110MP0001502_abnormal_circadian_rhythm0.77801787
111MP0002557_abnormal_social/conspecific_i0.77226123
112MP0002106_abnormal_muscle_physiology0.76846300
113MP0005000_abnormal_immune_tolerance0.76213531
114MP0005330_cardiomyopathy0.76087943
115MP0002882_abnormal_neuron_morphology0.76032923
116MP0003191_abnormal_cellular_cholesterol0.75700426
117MP0003787_abnormal_imprinting0.75163801
118MP0005621_abnormal_cell_physiology0.74880390
119MP0003690_abnormal_glial_cell0.74787076
120MP0005464_abnormal_platelet_physiology0.74076020
121MP0005257_abnormal_intraocular_pressure0.73580947
122MP0002067_abnormal_sensory_capabilities0.70558754
123MP0002184_abnormal_innervation0.70554743
124MP0005535_abnormal_body_temperature0.70035175
125MP0004484_altered_response_of0.69824163
126MP0003137_abnormal_impulse_conducting0.69020193
127MP0000685_abnormal_immune_system0.68786118
128MP0003763_abnormal_thymus_physiology0.68740343
129MP0003091_abnormal_cell_migration0.68234944
130MP0002069_abnormal_eating/drinking_beha0.68083887
131MP0005083_abnormal_biliary_tract0.67501550
132MP0009672_abnormal_birth_weight0.67178549
133MP0003279_aneurysm0.67117733
134MP0010329_abnormal_lipoprotein_level0.66735376
135MP0004215_abnormal_myocardial_fiber0.64261421
136MP0000703_abnormal_thymus_morphology0.63642658
137MP0009931_abnormal_skin_appearance0.62724087
138MP0003942_abnormal_urinary_system0.62595064
139MP0000490_abnormal_crypts_of0.62113266
140MP0001730_embryonic_growth_arrest0.61939403
141MP0009053_abnormal_anal_canal0.61284108
142MP0000534_abnormal_ureter_morphology0.61001454
143MP0002398_abnormal_bone_marrow0.60078649
144MP0004264_abnormal_extraembryonic_tissu0.56368502
145MP0004381_abnormal_hair_follicle0.55933386

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.01780398
2Abnormality of the lower motor neuron (HP:0002366)3.73124212
3Visual hallucinations (HP:0002367)3.47831175
4Hyperacusis (HP:0010780)3.38594567
5Insomnia (HP:0100785)3.31324347
6Dysmetric saccades (HP:0000641)3.17191052
7Annular pancreas (HP:0001734)2.87654116
8Neurofibrillary tangles (HP:0002185)2.86416475
9Focal seizures (HP:0007359)2.86020796
10Papilledema (HP:0001085)2.73502675
11Achilles tendon contracture (HP:0001771)2.72760306
12Supranuclear gaze palsy (HP:0000605)2.72630634
13Action tremor (HP:0002345)2.71695912
14Bundle branch block (HP:0011710)2.70923321
15Macroorchidism (HP:0000053)2.65997212
16Pointed chin (HP:0000307)2.64834478
17Distal upper limb amyotrophy (HP:0007149)2.62412712
18Upper limb amyotrophy (HP:0009129)2.62412712
19Focal motor seizures (HP:0011153)2.61897392
20Abnormality of the Achilles tendon (HP:0005109)2.60970508
21Hyperparathyroidism (HP:0000843)2.59904386
22Impaired social interactions (HP:0000735)2.57026702
23Abnormal social behavior (HP:0012433)2.57026702
24Cerebral aneurysm (HP:0004944)2.56264738
25Depression (HP:0000716)2.55659102
26Elfin facies (HP:0004428)2.51827934
27Ventricular fibrillation (HP:0001663)2.48636257
28Long palpebral fissure (HP:0000637)2.48208890
29Postural instability (HP:0002172)2.45101326
30Hemiplegia (HP:0002301)2.43368830
31Disproportionate tall stature (HP:0001519)2.42355933
32Urinary urgency (HP:0000012)2.41965787
33Impaired vibration sensation in the lower limbs (HP:0002166)2.38537914
34Difficulty running (HP:0009046)2.36097030
35Urinary bladder sphincter dysfunction (HP:0002839)2.34023340
36Exercise-induced myalgia (HP:0003738)2.33918615
37Resting tremor (HP:0002322)2.33216134
38Distal lower limb amyotrophy (HP:0008944)2.31082916
39Poor eye contact (HP:0000817)2.30259252
40Ankyloglossia (HP:0010296)2.29314950
41Hyperthyroidism (HP:0000836)2.27826124
42Myopathic facies (HP:0002058)2.27437358
43Segmental peripheral demyelination/remyelination (HP:0003481)2.26663564
44Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.23892661
45Ankle clonus (HP:0011448)2.22646573
46Hand muscle atrophy (HP:0009130)2.22090149
47Slow saccadic eye movements (HP:0000514)2.20061749
48Broad face (HP:0000283)2.18029446
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.17323479
50Cerebral inclusion bodies (HP:0100314)2.15951231
51Enlarged penis (HP:0000040)2.15641065
52Lower limb amyotrophy (HP:0007210)2.15598243
53Hypercortisolism (HP:0001578)2.15014034
54Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14631104
55Genetic anticipation (HP:0003743)2.14422599
56Termporal pattern (HP:0011008)2.13987014
57Insidious onset (HP:0003587)2.13987014
58Thin bony cortex (HP:0002753)2.12218797
59Rapidly progressive (HP:0003678)2.11481409
60Renovascular hypertension (HP:0100817)2.11438747
61Ulnar bowing (HP:0003031)2.10549263
62Peripheral hypomyelination (HP:0007182)2.10279735
63Renal duplication (HP:0000075)2.07767235
64Sudden death (HP:0001699)2.06863326
65Overriding aorta (HP:0002623)2.06046674
66Eczematoid dermatitis (HP:0000976)2.05861654
67Shallow orbits (HP:0000586)2.04645883
68Protrusio acetabuli (HP:0003179)2.04386010
69Dysdiadochokinesis (HP:0002075)2.04180918
70Bowel incontinence (HP:0002607)2.03576736
71Neoplasm of the heart (HP:0100544)2.03157472
72Turricephaly (HP:0000262)2.02507165
73Vertebral compression fractures (HP:0002953)2.01343780
74Exercise-induced muscle cramps (HP:0003710)2.01134162
75Truncus arteriosus (HP:0001660)1.98390192
76Increased connective tissue (HP:0009025)1.97290982
77Lymphangioma (HP:0100764)1.96285608
78Stridor (HP:0010307)1.96265777
79Increased cerebral lipofuscin (HP:0011813)1.93817376
80Obstructive sleep apnea (HP:0002870)1.93804226
81Mitral regurgitation (HP:0001653)1.93786825
82Hyporeflexia of lower limbs (HP:0002600)1.93468124
83Hamartoma of the eye (HP:0010568)1.92468233
84Axonal loss (HP:0003447)1.92049551
85Abnormal large intestine physiology (HP:0012700)1.91082113
86Amyotrophic lateral sclerosis (HP:0007354)1.90847002
87Impaired smooth pursuit (HP:0007772)1.89213454
88Abnormality of skeletal muscle fiber size (HP:0012084)1.89059399
89Polygenic inheritance (HP:0010982)1.88864240
90Reticulocytosis (HP:0001923)1.88635256
91Intention tremor (HP:0002080)1.88470740
92Generalized tonic-clonic seizures (HP:0002069)1.87749088
93Abnormality of oral frenula (HP:0000190)1.86463883
94Torticollis (HP:0000473)1.86287947
95Astrocytoma (HP:0009592)1.86065527
96Abnormality of the astrocytes (HP:0100707)1.86065527
97Global brain atrophy (HP:0002283)1.84010191
98Cellulitis (HP:0100658)1.83287938
99Distal lower limb muscle weakness (HP:0009053)1.80878245
100Absence seizures (HP:0002121)1.80431588
101Cholecystitis (HP:0001082)1.78411191
102Abnormal gallbladder physiology (HP:0012438)1.78411191
103Apathy (HP:0000741)1.76789925
104Atrioventricular block (HP:0001678)1.76669204
105Diminished motivation (HP:0000745)1.76574239
106Fibroma (HP:0010614)1.75824176
107Deep palmar crease (HP:0006191)1.74668360
108Easy fatigability (HP:0003388)1.74364340
109Decreased motor nerve conduction velocity (HP:0003431)1.74184368
110Dysmetria (HP:0001310)1.73186365
111Heart block (HP:0012722)1.73163845
112Intellectual disability, profound (HP:0002187)1.73029044
113Onion bulb formation (HP:0003383)1.72429782
114Difficulty climbing stairs (HP:0003551)1.72026583
115Status epilepticus (HP:0002133)1.71990892
116Foot dorsiflexor weakness (HP:0009027)1.71399888
117Frequent falls (HP:0002359)1.71273943
118Hypertensive crisis (HP:0100735)1.71206520
119Abnormality of the fingertips (HP:0001211)1.70782081
120Patellar dislocation (HP:0002999)1.69635063
121Hypercalcemia (HP:0003072)1.69397418
122Heterotopia (HP:0002282)1.69148568
123Increased IgE level (HP:0003212)1.69103644
124Increased variability in muscle fiber diameter (HP:0003557)1.68866356
125Bowel diverticulosis (HP:0005222)1.68842865
126Growth hormone excess (HP:0000845)1.68756548
127Abnormality of the thoracic spine (HP:0100711)1.68278044
128Truncal ataxia (HP:0002078)1.68236299
129Increased neuronal autofluorescent lipopigment (HP:0002074)1.67901258
130Diplopia (HP:0000651)1.67292875
131Abnormality of binocular vision (HP:0011514)1.67292875
132EMG: neuropathic changes (HP:0003445)1.67011372
133Striae distensae (HP:0001065)1.66936830
134Megalencephaly (HP:0001355)1.66803095
135Mitral valve prolapse (HP:0001634)1.66677027
136Abnormality of ocular smooth pursuit (HP:0000617)1.66411897
137Genu recurvatum (HP:0002816)1.66058886
138Fibrous tissue neoplasm (HP:0012316)1.65793742
139Lower limb asymmetry (HP:0100559)1.65413483
140Polycythemia (HP:0001901)1.65110701
141Hemorrhage of the eye (HP:0011885)1.64519589
142Neuronal loss in central nervous system (HP:0002529)1.64408360
143Abnormality of the distal phalanx of the thumb (HP:0009617)1.64374175
144Broad distal phalanx of finger (HP:0009836)1.63914568
145Aneurysm (HP:0002617)1.63747974
146Obsessive-compulsive behavior (HP:0000722)1.63019319
147Fragile skin (HP:0001030)1.62540541
148Abnormal atrioventricular conduction (HP:0005150)1.62454642
149Bradykinesia (HP:0002067)1.61416064
150Myoglobinuria (HP:0002913)1.61170387
151Focal dystonia (HP:0004373)1.61033127
152Spinal canal stenosis (HP:0003416)1.60299090
153Arnold-Chiari malformation (HP:0002308)1.60258489
154Rigidity (HP:0002063)1.58067072
155Distal sensory impairment (HP:0002936)1.57883874
156Dysostosis multiplex (HP:0000943)1.57671894
157Abnormality of macrophages (HP:0004311)1.57321089
158Supernumerary nipples (HP:0002558)1.57313773
159Amyloidosis (HP:0011034)1.57312398
160Akinesia (HP:0002304)1.56051185
161Tetraplegia (HP:0002445)1.54113222
162Spinal cord lesions (HP:0100561)1.53932107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.19739955
2MAP3K93.05377441
3PKN22.96192197
4SMG12.93920990
5PRKD32.59807050
6KSR22.42356903
7IRAK32.32122886
8EEF2K2.18503962
9TAOK12.15496235
10PAK62.05311644
11TYRO32.04038393
12NTRK32.02948164
13EPHA42.02345374
14RIPK12.00218738
15ICK1.98397013
16DAPK21.97824246
17CAMKK11.94931061
18MAP3K101.92629198
19ALK1.85708473
20SIK21.71481738
21MAP2K31.56229960
22CDK121.54702041
23BMX1.52339977
24TAOK21.49490793
25ARAF1.48781137
26MINK11.47570460
27LATS21.46480402
28PDGFRA1.44852873
29MAP3K41.44265881
30STK381.43612163
31MARK11.42255083
32NEK11.36582884
33IRAK21.32142083
34NME21.30949245
35ERN11.30219927
36RET1.28752267
37TTN1.25940531
38MAP3K71.25397433
39NTRK11.23959118
40DMPK1.23611481
41PTK61.22778206
42MAP3K21.17762511
43NTRK21.17384545
44CAMK1G1.14627253
45MAP2K41.12256475
46SCYL21.11646869
47PHKG11.06959826
48PHKG21.06959826
49KSR11.05227548
50LMTK21.03436216
51DAPK11.00680477
52BRAF0.98642780
53DDR20.95662880
54CDK50.95066830
55STK110.95018945
56IRAK40.93557221
57GRK60.92455202
58SIK10.91845277
59UHMK10.88645192
60MAPK120.87625138
61PDK10.86735265
62MARK20.86213193
63MAP3K30.83326484
64SIK30.80062722
65CAMK1D0.79345590
66TESK10.77682944
67PDPK10.77545625
68MAP3K10.75714756
69TESK20.75229300
70CDC42BPA0.72539626
71MTOR0.71767835
72MAP2K20.66661680
73PRKD20.66397109
74RPS6KC10.66214078
75RPS6KL10.66214078
76LRRK20.65936253
77FES0.65424010
78ZAP700.63597742
79MOS0.63120044
80PDGFRB0.62278523
81RIPK40.61316786
82PRKG20.60823909
83CDK150.59423634
84MAP3K80.58519733
85PAK30.58213994
86PRPF4B0.57949419
87PTK20.57422623
88JAK20.55385743
89CAMK40.55090329
90MAPK110.55022091
91CSK0.54439228
92* PRKCH0.52795086
93CDK180.52785269
94PTK2B0.52423899
95CDK11A0.51727694
96CDK60.51715695
97CAMK10.51438224
98CDK140.50481305
99DYRK1B0.50327161
100WNK10.50205398
101PRKD10.50131036
102EPHB10.50016447
103TYK20.49813897
104RPS6KA20.49412983
105MAP3K110.49117307
106CDK190.48592200
107MAP3K130.48429161
108PINK10.47686114
109RPS6KA60.47353562
110RAF10.47186119
111EPHA20.46477827
112MAP3K60.46280483
113PRKAA10.45194483
114TNK20.45030821
115* RPS6KA30.44907776
116PAK40.44417379
117TBK10.43215437
118GRK50.43202383
119FGFR30.42929790
120MAP4K10.42685196
121DAPK30.40493005
122FYN0.39631579
123FGFR20.39142281
124MAPK100.38753752
125FGFR10.38310664
126PRKCZ0.38098610
127MAP2K10.37697071
128HIPK20.37643166
129RPS6KA10.37404403
130FGFR40.37090387

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.95996877
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14372579
3Long-term potentiation_Homo sapiens_hsa047201.89287305
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.85850585
5Olfactory transduction_Homo sapiens_hsa047401.80605353
6Synaptic vesicle cycle_Homo sapiens_hsa047211.78860281
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75526207
8Notch signaling pathway_Homo sapiens_hsa043301.62908577
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60048777
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59414125
11Gastric acid secretion_Homo sapiens_hsa049711.57567266
12Glioma_Homo sapiens_hsa052141.53195211
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52711441
14Circadian entrainment_Homo sapiens_hsa047131.51157094
15mTOR signaling pathway_Homo sapiens_hsa041501.48758459
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43578322
17Salivary secretion_Homo sapiens_hsa049701.42010510
18Type II diabetes mellitus_Homo sapiens_hsa049301.39780161
19GABAergic synapse_Homo sapiens_hsa047271.39533722
20Amphetamine addiction_Homo sapiens_hsa050311.36263106
21Glutamatergic synapse_Homo sapiens_hsa047241.35731752
22Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.34244108
23Estrogen signaling pathway_Homo sapiens_hsa049151.33053406
24Oxytocin signaling pathway_Homo sapiens_hsa049211.31249538
25Dorso-ventral axis formation_Homo sapiens_hsa043201.30624542
26Osteoclast differentiation_Homo sapiens_hsa043801.30431204
27GnRH signaling pathway_Homo sapiens_hsa049121.29018169
28VEGF signaling pathway_Homo sapiens_hsa043701.28064693
29Cholinergic synapse_Homo sapiens_hsa047251.26758181
30Insulin secretion_Homo sapiens_hsa049111.26495697
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22692948
32* Dopaminergic synapse_Homo sapiens_hsa047281.21837096
33Morphine addiction_Homo sapiens_hsa050321.21481810
34Non-small cell lung cancer_Homo sapiens_hsa052231.21418832
35Other glycan degradation_Homo sapiens_hsa005111.18614301
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17127145
37Arginine biosynthesis_Homo sapiens_hsa002201.16148715
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.14643011
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13584331
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.13052934
41Gap junction_Homo sapiens_hsa045401.12728411
42Endometrial cancer_Homo sapiens_hsa052131.10273895
43Renin secretion_Homo sapiens_hsa049241.10212005
44Chronic myeloid leukemia_Homo sapiens_hsa052201.08917846
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07524938
46Bile secretion_Homo sapiens_hsa049761.07168733
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07065115
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06535955
49Nicotine addiction_Homo sapiens_hsa050331.05770394
50ErbB signaling pathway_Homo sapiens_hsa040121.04893044
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.01507196
52Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01048135
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01018914
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00340109
55Insulin signaling pathway_Homo sapiens_hsa049100.99617118
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98767998
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.96636593
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95866063
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.95307943
60Dilated cardiomyopathy_Homo sapiens_hsa054140.94966991
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.94916548
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.94407989
63Cocaine addiction_Homo sapiens_hsa050300.94198979
64Long-term depression_Homo sapiens_hsa047300.92988987
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92528909
66Glucagon signaling pathway_Homo sapiens_hsa049220.91635959
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91241906
68cAMP signaling pathway_Homo sapiens_hsa040240.91096857
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90583309
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89874389
71Insulin resistance_Homo sapiens_hsa049310.89661987
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89393433
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88651748
74Renal cell carcinoma_Homo sapiens_hsa052110.86939029
75Inositol phosphate metabolism_Homo sapiens_hsa005620.86790676
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85614898
77Melanogenesis_Homo sapiens_hsa049160.84626236
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81223378
79Hepatitis C_Homo sapiens_hsa051600.80330558
80Hepatitis B_Homo sapiens_hsa051610.78841841
81Tuberculosis_Homo sapiens_hsa051520.78767485
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.78302479
83Choline metabolism in cancer_Homo sapiens_hsa052310.78239492
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78227199
85Leishmaniasis_Homo sapiens_hsa051400.77847386
86Vibrio cholerae infection_Homo sapiens_hsa051100.77583648
87Calcium signaling pathway_Homo sapiens_hsa040200.77228670
88TNF signaling pathway_Homo sapiens_hsa046680.76820842
89Endocytosis_Homo sapiens_hsa041440.76806086
90Fatty acid biosynthesis_Homo sapiens_hsa000610.76630538
91MAPK signaling pathway_Homo sapiens_hsa040100.76221956
92* Chemokine signaling pathway_Homo sapiens_hsa040620.75263510
93Salmonella infection_Homo sapiens_hsa051320.74681948
94AMPK signaling pathway_Homo sapiens_hsa041520.74167499
95Proteoglycans in cancer_Homo sapiens_hsa052050.74055683
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74018890
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.73256620
98Pentose phosphate pathway_Homo sapiens_hsa000300.71355309
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70925923
100Apoptosis_Homo sapiens_hsa042100.70475066
101Lysine degradation_Homo sapiens_hsa003100.69553756
102Bladder cancer_Homo sapiens_hsa052190.69074945
103Colorectal cancer_Homo sapiens_hsa052100.69035740
104Thyroid hormone synthesis_Homo sapiens_hsa049180.67517410
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67132593
106Rap1 signaling pathway_Homo sapiens_hsa040150.66866442
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.66833336
108B cell receptor signaling pathway_Homo sapiens_hsa046620.65779337
109Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65593670
110Acute myeloid leukemia_Homo sapiens_hsa052210.65554764
111Prolactin signaling pathway_Homo sapiens_hsa049170.65406307
112Oocyte meiosis_Homo sapiens_hsa041140.64919569
113Fructose and mannose metabolism_Homo sapiens_hsa000510.64072179
114Pancreatic cancer_Homo sapiens_hsa052120.63671638
115Prostate cancer_Homo sapiens_hsa052150.61651032
116Focal adhesion_Homo sapiens_hsa045100.61183377
117Axon guidance_Homo sapiens_hsa043600.60195906
118Platelet activation_Homo sapiens_hsa046110.60175431
119Toxoplasmosis_Homo sapiens_hsa051450.60049147
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.59618108
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57023075
122HIF-1 signaling pathway_Homo sapiens_hsa040660.57005668
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56559819
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55568046
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53815927
126T cell receptor signaling pathway_Homo sapiens_hsa046600.52973446
127Prion diseases_Homo sapiens_hsa050200.52303627
128Amoebiasis_Homo sapiens_hsa051460.49897393
129Thyroid cancer_Homo sapiens_hsa052160.49866995

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