GSKIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.43335259
2polyketide metabolic process (GO:0030638)6.43335259
3doxorubicin metabolic process (GO:0044598)6.43335259
4cullin deneddylation (GO:0010388)5.70183907
5protein deneddylation (GO:0000338)5.25577855
6DNA double-strand break processing (GO:0000729)4.71082274
7regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.23998137
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.22698483
9protein complex biogenesis (GO:0070271)4.19231156
10protein neddylation (GO:0045116)4.19046199
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.11738312
12NADH dehydrogenase complex assembly (GO:0010257)4.11738312
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.11738312
14establishment of integrated proviral latency (GO:0075713)4.09103660
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.02750831
16anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.02367150
17transferrin transport (GO:0033572)3.99387675
18energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.98441958
19ATP hydrolysis coupled proton transport (GO:0015991)3.98441958
20energy coupled proton transport, down electrochemical gradient (GO:0015985)3.88138156
21ATP synthesis coupled proton transport (GO:0015986)3.88138156
22aminoglycoside antibiotic metabolic process (GO:0030647)3.85639434
23phagosome maturation (GO:0090382)3.79467271
24chaperone-mediated protein transport (GO:0072321)3.79442382
25ribosome assembly (GO:0042255)3.73299683
26electron transport chain (GO:0022900)3.68453516
27respiratory electron transport chain (GO:0022904)3.66647126
28trivalent inorganic cation transport (GO:0072512)3.66164666
29ferric iron transport (GO:0015682)3.66164666
30water-soluble vitamin biosynthetic process (GO:0042364)3.63950828
31mitochondrial respiratory chain complex assembly (GO:0033108)3.63938159
32signal peptide processing (GO:0006465)3.60183921
33CENP-A containing nucleosome assembly (GO:0034080)3.58267188
34chromatin remodeling at centromere (GO:0031055)3.57191913
35positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.57150702
36respiratory chain complex IV assembly (GO:0008535)3.51492177
37mitotic metaphase plate congression (GO:0007080)3.46800100
38positive regulation of ligase activity (GO:0051351)3.46756576
39regulation of mitotic spindle checkpoint (GO:1903504)3.40586669
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.40586669
41cytochrome complex assembly (GO:0017004)3.40500956
42metaphase plate congression (GO:0051310)3.40221985
43rRNA methylation (GO:0031167)3.39602581
44L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.39526320
45mitochondrial DNA replication (GO:0006264)3.38139013
46proteasome assembly (GO:0043248)3.37891205
47GDP-mannose metabolic process (GO:0019673)3.35805646
48interferon-gamma production (GO:0032609)3.34829301
49protein localization to cilium (GO:0061512)3.31923201
50establishment of viral latency (GO:0019043)3.31042443
51intestinal epithelial cell development (GO:0060576)3.29627624
52ribosomal small subunit biogenesis (GO:0042274)3.28281065
53rRNA modification (GO:0000154)3.28276793
54regulation of meiosis I (GO:0060631)3.27159098
55pteridine-containing compound biosynthetic process (GO:0042559)3.27144372
56regulation of ubiquitin-protein transferase activity (GO:0051438)3.26594871
57quinone metabolic process (GO:1901661)3.25877930
58DNA damage response, detection of DNA damage (GO:0042769)3.19631214
59regulation of ligase activity (GO:0051340)3.19182849
60inositol phosphate catabolic process (GO:0071545)3.17220488
61protein-cofactor linkage (GO:0018065)3.16386977
62regulation of guanylate cyclase activity (GO:0031282)3.16267653
63antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.14238606
64negative regulation of DNA recombination (GO:0045910)3.14042182
65purine nucleobase biosynthetic process (GO:0009113)3.09900153
66DNA replication-dependent nucleosome organization (GO:0034723)3.07152622
67DNA replication-dependent nucleosome assembly (GO:0006335)3.07152622
68histone exchange (GO:0043486)3.07013014
69regulation of cilium movement (GO:0003352)3.05995922
70spindle checkpoint (GO:0031577)3.05334184
71calcium-mediated signaling using intracellular calcium source (GO:0035584)3.05143610
72mitotic spindle checkpoint (GO:0071174)3.03747972
73antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.03349378
74neurotransmitter uptake (GO:0001504)3.00881650
75histone mRNA metabolic process (GO:0008334)2.99096662
76DNA ligation (GO:0006266)2.99039909
77activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.96678772
78negative regulation of dendrite morphogenesis (GO:0050774)2.95260152
79tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94666342
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94666342
81DNA catabolic process, exonucleolytic (GO:0000738)2.93470493
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93138021
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92449860
84positive regulation of mitochondrial fission (GO:0090141)2.91447055
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90646628
86negative regulation of DNA-dependent DNA replication (GO:2000104)2.90430314
87regulation of cellular amino acid metabolic process (GO:0006521)2.89994577
88cellular glucuronidation (GO:0052695)2.89269198
89regulation of cellular amine metabolic process (GO:0033238)2.89018187
90protein K11-linked ubiquitination (GO:0070979)2.88796743
91nucleotide-sugar biosynthetic process (GO:0009226)2.85854107
92viral protein processing (GO:0019082)2.85674130
93folic acid-containing compound biosynthetic process (GO:0009396)2.85540139
94glucuronate metabolic process (GO:0019585)2.84866878
95uronic acid metabolic process (GO:0006063)2.84866878
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.84801939
97regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84801939
98negative regulation of synaptic transmission, GABAergic (GO:0032229)2.84775719
99neuronal action potential propagation (GO:0019227)2.84754464
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.84412717
101signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.84412717
102negative regulation of mitotic sister chromatid separation (GO:2000816)2.84166050
103negative regulation of sister chromatid segregation (GO:0033046)2.84166050
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.84166050
105negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84166050
106negative regulation of mitotic sister chromatid segregation (GO:0033048)2.84166050
107glycoside metabolic process (GO:0016137)2.84149354
108establishment of protein localization to mitochondrial membrane (GO:0090151)2.83821922
109lactate metabolic process (GO:0006089)2.83697137
110negative regulation of protein ubiquitination (GO:0031397)2.83157882
111mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.82993312
112pseudouridine synthesis (GO:0001522)2.82521582
113hydrogen ion transmembrane transport (GO:1902600)2.81642123
114establishment of chromosome localization (GO:0051303)2.81159056
115peptidyl-cysteine modification (GO:0018198)2.79602849
116protein localization to kinetochore (GO:0034501)2.79236491
117cytidine metabolic process (GO:0046087)2.78659328
118cytidine catabolic process (GO:0006216)2.78659328
119cytidine deamination (GO:0009972)2.78659328
120signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77794780
121signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.77794780
122signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77794780
123positive regulation of guanylate cyclase activity (GO:0031284)2.76359151
124regulation of sister chromatid segregation (GO:0033045)2.74705376
125regulation of mitotic sister chromatid separation (GO:0010965)2.74705376
126regulation of mitotic sister chromatid segregation (GO:0033047)2.74705376
127positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.73473383
128positive regulation of mitotic sister chromatid separation (GO:1901970)2.73473383
129positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.73473383
130nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72921723
131melanosome transport (GO:0032402)2.72774150
132inositol phosphate dephosphorylation (GO:0046855)2.72710734
133phosphorylated carbohydrate dephosphorylation (GO:0046838)2.72710734
134dopamine transport (GO:0015872)2.72655771
135negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.71780540
136negative regulation of chromosome segregation (GO:0051985)2.71714314
137negative regulation of ligase activity (GO:0051352)2.71475300
138negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71475300
139somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.70894913
140isotype switching (GO:0045190)2.70894913
141somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.70894913
142proton transport (GO:0015992)2.69546581
143DNA replication-independent nucleosome assembly (GO:0006336)2.68786178
144DNA replication-independent nucleosome organization (GO:0034724)2.68786178
145synaptic vesicle exocytosis (GO:0016079)2.68225799
146protein targeting to mitochondrion (GO:0006626)2.66427646
147attachment of spindle microtubules to kinetochore (GO:0008608)2.65846552
148antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.64551989
149establishment of melanosome localization (GO:0032401)2.64200909
150non-recombinational repair (GO:0000726)2.64110165
151double-strand break repair via nonhomologous end joining (GO:0006303)2.64110165
152hydrogen transport (GO:0006818)2.63857323
153NADH metabolic process (GO:0006734)2.61903664
154pigment granule transport (GO:0051904)2.60786569
155signal transduction involved in DNA integrity checkpoint (GO:0072401)2.59204117
156signal transduction involved in DNA damage checkpoint (GO:0072422)2.59204117
157cellular component biogenesis (GO:0044085)2.57642655
158signal transduction involved in cell cycle checkpoint (GO:0072395)2.54438247
159presynaptic membrane assembly (GO:0097105)2.54337590
160establishment of pigment granule localization (GO:0051905)2.53147911
161regulation of axon regeneration (GO:0048679)2.49619921
162regulation of neuron projection regeneration (GO:0070570)2.49619921
163positive regulation of TOR signaling (GO:0032008)2.48799651
164melanosome localization (GO:0032400)2.48661447
165establishment of protein localization to mitochondrion (GO:0072655)2.46063102
166detection of temperature stimulus (GO:0016048)2.45716560
167antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.44218269
168neutrophil activation involved in immune response (GO:0002283)2.43301642
169negative regulation of signal transduction by p53 class mediator (GO:1901797)2.42737099
170cotranslational protein targeting to membrane (GO:0006613)2.42201969
171rRNA transcription (GO:0009303)2.41166023
172positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.39927324
173pigment granule localization (GO:0051875)2.39177010
174regulation of mitochondrial translation (GO:0070129)2.37265650
175GTP biosynthetic process (GO:0006183)2.37175882
176cyclooxygenase pathway (GO:0019371)2.36948323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human6.16735341
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.05546193
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.34144234
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.85284611
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.39061455
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07356670
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.91357994
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89647913
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84165527
10PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.67987920
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52145032
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46151802
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.40356859
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36617947
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.23578702
16IGF1R_20145208_ChIP-Seq_DFB_Human2.18543528
17ZNF274_21170338_ChIP-Seq_K562_Hela2.16521118
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11712420
19YY1_21170310_ChIP-Seq_MESCs_Mouse2.00854701
20ELK1_19687146_ChIP-ChIP_HELA_Human1.95531948
21PADI4_21655091_ChIP-ChIP_MCF-7_Human1.95182999
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94954870
23ELK1_22589737_ChIP-Seq_MCF10A_Human1.91257105
24AR_21909140_ChIP-Seq_LNCAP_Human1.90325526
25EWS_26573619_Chip-Seq_HEK293_Human1.90154584
26VDR_23849224_ChIP-Seq_CD4+_Human1.87921175
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87019051
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85844892
29SRF_21415370_ChIP-Seq_HL-1_Mouse1.84800335
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.84626711
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82256480
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.80935319
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.79721922
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79480091
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78702735
36FUS_26573619_Chip-Seq_HEK293_Human1.76555053
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.72607988
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72008233
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.71950135
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71830440
41IRF1_19129219_ChIP-ChIP_H3396_Human1.69878163
42E2F7_22180533_ChIP-Seq_HELA_Human1.69756647
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68953090
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.65998402
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.65998402
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.65998402
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.63046920
48VDR_22108803_ChIP-Seq_LS180_Human1.61665423
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59168877
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52692365
51FOXP3_21729870_ChIP-Seq_TREG_Human1.52365829
52TAF15_26573619_Chip-Seq_HEK293_Human1.49317275
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47509693
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45858869
55GBX2_23144817_ChIP-Seq_PC3_Human1.45803110
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.44993118
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39187056
58MYC_18940864_ChIP-ChIP_HL60_Human1.38574113
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37847022
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37004355
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36181864
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35466173
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34547869
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33667726
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.33092628
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.32675416
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32652452
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24286470
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22195274
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.22034646
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20149589
72DCP1A_22483619_ChIP-Seq_HELA_Human1.19698354
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19541825
74CDX2_22108803_ChIP-Seq_LS180_Human1.17129538
75SPI1_23547873_ChIP-Seq_NB4_Human1.17044634
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16713629
77RNF2_27304074_Chip-Seq_NSC_Mouse1.16170192
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15980581
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15799470
80HTT_18923047_ChIP-ChIP_STHdh_Human1.15046006
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14381140
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12702552
83CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.12611440
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12414094
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11930579
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.11435271
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11341033
88GABP_19822575_ChIP-Seq_HepG2_Human1.10796168
89SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10411199
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10355206
91BCAT_22108803_ChIP-Seq_LS180_Human1.09099828
92JUN_21703547_ChIP-Seq_K562_Human1.09057598
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08136305
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07965066
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.06845259
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06416498
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06377451
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05346118
99STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04875863
100YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03179518
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.02771183
102TTF2_22483619_ChIP-Seq_HELA_Human1.02701066
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00886379
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00826477
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00285077
106ELF5_23300383_ChIP-Seq_T47D_Human0.99460568
107MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99042582
108WT1_19549856_ChIP-ChIP_CCG9911_Human0.98934329
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98255942
110FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97676776
111FOXA1_25329375_ChIP-Seq_VCAP_Human0.97676776
112ER_23166858_ChIP-Seq_MCF-7_Human0.97163908
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96997915
114CBP_20019798_ChIP-Seq_JUKART_Human0.96997915
115SALL4_22934838_ChIP-ChIP_CD34+_Human0.96363047
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96324127
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96219973
118MYC_18555785_ChIP-Seq_MESCs_Mouse0.96043502
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96042517
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94735408
121E2F1_17053090_ChIP-ChIP_MCF-7_Human0.94506135
122RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92556814
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92151809
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91950184
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91818824
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.91608976
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91600226
128PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91538367
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90762997
130MYC_19030024_ChIP-ChIP_MESCs_Mouse0.90057707
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88498975
132REST_18959480_ChIP-ChIP_MESCs_Mouse0.86143939
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85520204
134CTBP1_25329375_ChIP-Seq_LNCAP_Human0.84930110
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84269889
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83141841
137FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82601412
138REST_21632747_ChIP-Seq_MESCs_Mouse0.81993973
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81879050
140NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81879050
141P300_19829295_ChIP-Seq_ESCs_Human0.81521611
142CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81473799
143NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81178140
144MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.79577121
145NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79260949
146FOXA1_21572438_ChIP-Seq_LNCaP_Human0.78621336
147ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77250749
148MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.76935563
149SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.76761540
150ETV2_25802403_ChIP-Seq_MESCs_Mouse0.75779831
151CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75337534
152EOMES_21245162_ChIP-Seq_HESCs_Human0.75191943
153EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74878854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.00166159
2MP0003718_maternal_effect3.88325387
3MP0002102_abnormal_ear_morphology3.67852951
4MP0003693_abnormal_embryo_hatching3.46025720
5MP0003806_abnormal_nucleotide_metabolis3.41016902
6MP0003880_abnormal_central_pattern3.34480585
7MP0003183_abnormal_peptide_metabolism3.16743701
8MP0003941_abnormal_skin_development3.00644456
9MP0003122_maternal_imprinting2.99389618
10MP0002736_abnormal_nociception_after2.90940769
11MP0001968_abnormal_touch/_nociception2.90387739
12MP0003890_abnormal_embryonic-extraembry2.89244388
13MP0008058_abnormal_DNA_repair2.89045645
14MP0009046_muscle_twitch2.72033392
15MP0001905_abnormal_dopamine_level2.63047172
16MP0005085_abnormal_gallbladder_physiolo2.62656322
17MP0003724_increased_susceptibility_to2.59258778
18MP0001666_abnormal_nutrient_absorption2.54957954
19MP0005360_urolithiasis2.45502720
20MP0002139_abnormal_hepatobiliary_system2.36746687
21MP0008877_abnormal_DNA_methylation2.35415907
22MP0003011_delayed_dark_adaptation2.32523833
23MP0002064_seizures2.31186441
24MP0005075_abnormal_melanosome_morpholog2.16420294
25MP0006035_abnormal_mitochondrial_morpho2.16004502
26MP0002735_abnormal_chemical_nociception2.15565069
27MP0009745_abnormal_behavioral_response2.14152528
28MP0004142_abnormal_muscle_tone2.10561389
29MP0010094_abnormal_chromosome_stability2.08752006
30MP0008932_abnormal_embryonic_tissue2.08699729
31MP0004270_analgesia2.08261390
32MP0001986_abnormal_taste_sensitivity2.05593317
33MP0002734_abnormal_mechanical_nocicepti2.03407161
34MP0001501_abnormal_sleep_pattern2.01750736
35MP0008057_abnormal_DNA_replication2.00432616
36MP0006276_abnormal_autonomic_nervous1.97151386
37MP0009785_altered_susceptibility_to1.94503119
38MP0005671_abnormal_response_to1.93439225
39MP0001835_abnormal_antigen_presentation1.92962419
40MP0003635_abnormal_synaptic_transmissio1.90325400
41MP0010386_abnormal_urinary_bladder1.87638776
42MP0004858_abnormal_nervous_system1.87576501
43MP0002272_abnormal_nervous_system1.87464167
44MP0006054_spinal_hemorrhage1.84652498
45MP0002572_abnormal_emotion/affect_behav1.83334657
46MP0010352_gastrointestinal_tract_polyps1.82430432
47MP0004859_abnormal_synaptic_plasticity1.82424029
48MP0009379_abnormal_foot_pigmentation1.81418889
49MP0001529_abnormal_vocalization1.81330767
50MP0005394_taste/olfaction_phenotype1.79312614
51MP0005499_abnormal_olfactory_system1.79312614
52MP0008789_abnormal_olfactory_epithelium1.79058257
53MP0006082_CNS_inflammation1.78387386
54MP0001970_abnormal_pain_threshold1.78175347
55MP0003111_abnormal_nucleus_morphology1.76703263
56MP0002332_abnormal_exercise_endurance1.75887466
57MP0002148_abnormal_hypersensitivity_rea1.75885888
58MP0003786_premature_aging1.72233510
59MP0002733_abnormal_thermal_nociception1.71956059
60MP0006292_abnormal_olfactory_placode1.71929286
61MP0002063_abnormal_learning/memory/cond1.65264933
62MP0000372_irregular_coat_pigmentation1.64410779
63MP0001188_hyperpigmentation1.60468139
64MP0000427_abnormal_hair_cycle1.56576765
65MP0005000_abnormal_immune_tolerance1.53089162
66MP0003077_abnormal_cell_cycle1.51978111
67MP0005171_absent_coat_pigmentation1.45937448
68MP0001293_anophthalmia1.45885558
69MP0008007_abnormal_cellular_replicative1.45569596
70MP0005365_abnormal_bile_salt1.42659788
71MP0005367_renal/urinary_system_phenotyp1.42489142
72MP0000516_abnormal_urinary_system1.42489142
73MP0005395_other_phenotype1.42435482
74MP0006072_abnormal_retinal_apoptosis1.41679073
75MP0001542_abnormal_bone_strength1.39627745
76MP0002876_abnormal_thyroid_physiology1.39323592
77MP0006036_abnormal_mitochondrial_physio1.38088366
78MP0002796_impaired_skin_barrier1.37949772
79MP0001764_abnormal_homeostasis1.36275669
80MP0005084_abnormal_gallbladder_morpholo1.35141785
81MP0002277_abnormal_respiratory_mucosa1.33515797
82MP0003787_abnormal_imprinting1.32872011
83MP0003436_decreased_susceptibility_to1.32758538
84MP0005332_abnormal_amino_acid1.32359459
85MP0003252_abnormal_bile_duct1.31109357
86MP0002067_abnormal_sensory_capabilities1.30645851
87MP0005310_abnormal_salivary_gland1.29089411
88MP0004019_abnormal_vitamin_homeostasis1.27322006
89MP0001485_abnormal_pinna_reflex1.25222045
90MP0000647_abnormal_sebaceous_gland1.22687211
91MP0003123_paternal_imprinting1.18156158
92MP0004043_abnormal_pH_regulation1.17564216
93MP0009333_abnormal_splenocyte_physiolog1.16391145
94MP0010678_abnormal_skin_adnexa1.15896784
95MP0003937_abnormal_limbs/digits/tail_de1.13103666
96MP0004215_abnormal_myocardial_fiber1.12364798
97MP0001486_abnormal_startle_reflex1.12214515
98MP0002938_white_spotting1.11807188
99MP0005646_abnormal_pituitary_gland1.11493789
100MP0005025_abnormal_response_to1.10882507
101MP0010307_abnormal_tumor_latency1.09096211
102MP0002163_abnormal_gland_morphology1.09005755
103MP0001730_embryonic_growth_arrest1.08981420
104MP0003119_abnormal_digestive_system1.06639697
105MP0003121_genomic_imprinting1.05408639
106MP0001929_abnormal_gametogenesis1.05391920
107MP0000490_abnormal_crypts_of1.05005534
108MP0001348_abnormal_lacrimal_gland1.04480098
109MP0001440_abnormal_grooming_behavior1.04185924
110MP0003879_abnormal_hair_cell1.03450019
111MP0005636_abnormal_mineral_homeostasis1.02796930
112MP0008260_abnormal_autophagy1.01655773
113MP0002132_abnormal_respiratory_system1.00798381
114MP0002098_abnormal_vibrissa_morphology1.00498118
115MP0001984_abnormal_olfaction0.97502745
116MP0003186_abnormal_redox_activity0.95606591
117MP0002751_abnormal_autonomic_nervous0.95237400
118MP0002210_abnormal_sex_determination0.94965091
119MP0003567_abnormal_fetal_cardiomyocyte0.93139315
120MP0002420_abnormal_adaptive_immunity0.91550698
121MP0002723_abnormal_immune_serum0.90871890
122MP0003656_abnormal_erythrocyte_physiolo0.90688524
123MP0000653_abnormal_sex_gland0.90554188
124MP0001819_abnormal_immune_cell0.90151227
125MP0002254_reproductive_system_inflammat0.90148647
126MP0005387_immune_system_phenotype0.89697738
127MP0001790_abnormal_immune_system0.89697738
128MP0002233_abnormal_nose_morphology0.87688627
129MP0000749_muscle_degeneration0.87446136
130MP0002419_abnormal_innate_immunity0.86306466
131MP0004957_abnormal_blastocyst_morpholog0.85527514
132MP0003868_abnormal_feces_composition0.85279816
133MP0000920_abnormal_myelination0.84622393
134MP0001145_abnormal_male_reproductive0.83965105
135MP0005379_endocrine/exocrine_gland_phen0.83844129
136MP0002084_abnormal_developmental_patter0.82882352
137MP0000358_abnormal_cell_content/0.82650132
138MP0003221_abnormal_cardiomyocyte_apopto0.82467956
139MP0004782_abnormal_surfactant_physiolog0.82353955
140MP0002090_abnormal_vision0.82231642
141MP0005501_abnormal_skin_physiology0.80360764
142MP0005253_abnormal_eye_physiology0.80173137
143MP0005410_abnormal_fertilization0.79951881
144MP0002184_abnormal_innervation0.79329220
145MP0004811_abnormal_neuron_physiology0.78518252
146MP0001697_abnormal_embryo_size0.76819820
147MP0004147_increased_porphyrin_level0.76662253
148MP0000343_altered_response_to0.76522774
149MP0009697_abnormal_copulation0.75708963
150MP0004264_abnormal_extraembryonic_tissu0.75252174
151MP0002234_abnormal_pharynx_morphology0.75070400
152MP0002452_abnormal_antigen_presenting0.74361691
153MP0004381_abnormal_hair_follicle0.73126654
154MP0002909_abnormal_adrenal_gland0.73082961
155MP0001119_abnormal_female_reproductive0.71305167
156MP0001672_abnormal_embryogenesis/_devel0.71084536
157MP0005380_embryogenesis_phenotype0.71084536
158MP0003195_calcinosis0.71068771
159MP0008569_lethality_at_weaning0.68728852
160MP0000049_abnormal_middle_ear0.68419089
161MP0001727_abnormal_embryo_implantation0.68367761
162MP0001800_abnormal_humoral_immune0.67975895
163MP0008004_abnormal_stomach_pH0.67597457
164MP0002006_tumorigenesis0.67083922
165MP0002085_abnormal_embryonic_tissue0.65922577
166MP0002638_abnormal_pupillary_reflex0.65542514
167MP0001533_abnormal_skeleton_physiology0.65403753
168MP0002066_abnormal_motor_capabilities/c0.64432909
169MP0001664_abnormal_digestion0.63809430
170MP0008872_abnormal_physiological_respon0.63730034

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.20850044
2Abnormal mitochondria in muscle tissue (HP:0008316)4.92449953
3Mitochondrial inheritance (HP:0001427)4.56171959
4Abnormality of glycolysis (HP:0004366)4.54438526
5Increased serum pyruvate (HP:0003542)4.54438526
6Progressive macrocephaly (HP:0004481)4.32333089
7Increased CSF lactate (HP:0002490)4.19567410
8Hepatocellular necrosis (HP:0001404)4.11101902
93-Methylglutaconic aciduria (HP:0003535)4.00773211
10Abnormality of the labia minora (HP:0012880)3.97393093
11Methylmalonic acidemia (HP:0002912)3.92086173
12Focal motor seizures (HP:0011153)3.90782760
13Acute encephalopathy (HP:0006846)3.90385788
14Atonic seizures (HP:0010819)3.85984649
15Abnormality of vitamin B metabolism (HP:0004340)3.76510169
16Abnormality of the vitamin B12 metabolism (HP:0004341)3.72763432
17Hyperventilation (HP:0002883)3.62692520
18Microvesicular hepatic steatosis (HP:0001414)3.54073453
19Reduced antithrombin III activity (HP:0001976)3.47998113
20Type I transferrin isoform profile (HP:0003642)3.43809768
21Methylmalonic aciduria (HP:0012120)3.29941064
22Febrile seizures (HP:0002373)3.26341627
23Epileptic encephalopathy (HP:0200134)3.25960099
24Neuroendocrine neoplasm (HP:0100634)3.21925979
25Hepatic necrosis (HP:0002605)3.18410932
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.15269922
27Hypothermia (HP:0002045)3.13641549
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07183489
29Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07183489
30Renal Fanconi syndrome (HP:0001994)2.96488348
31Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.94780181
32Dialeptic seizures (HP:0011146)2.93169888
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.93144020
34Sensory axonal neuropathy (HP:0003390)2.91883145
35Bilateral microphthalmos (HP:0007633)2.90930399
36Increased hepatocellular lipid droplets (HP:0006565)2.90503272
37Increased serum lactate (HP:0002151)2.83847365
38Exercise intolerance (HP:0003546)2.77381975
39Respiratory failure (HP:0002878)2.74511918
40Pheochromocytoma (HP:0002666)2.72556476
41Ragged-red muscle fibers (HP:0003200)2.71499743
42Abnormal hair whorl (HP:0010721)2.69277373
43Neoplasm of the adrenal gland (HP:0100631)2.63381751
44Colon cancer (HP:0003003)2.62761485
45Absence seizures (HP:0002121)2.61491851
46Abnormality of vitamin metabolism (HP:0100508)2.61170903
47Failure to thrive in infancy (HP:0001531)2.60343017
48Abnormal pupillary function (HP:0007686)2.57634593
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.55863117
50Medial flaring of the eyebrow (HP:0010747)2.47852320
51Hyperglycinemia (HP:0002154)2.45819693
52Intrahepatic cholestasis (HP:0001406)2.45290898
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.45236506
54Lactic acidosis (HP:0003128)2.45174253
55Focal seizures (HP:0007359)2.42367908
56Proximal tubulopathy (HP:0000114)2.42233385
57Abnormal protein glycosylation (HP:0012346)2.41031946
58Abnormal glycosylation (HP:0012345)2.41031946
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.41031946
60Abnormal protein N-linked glycosylation (HP:0012347)2.41031946
61Abnormality of serum amino acid levels (HP:0003112)2.40865293
62Congenital primary aphakia (HP:0007707)2.39357292
63Abnormality of serine family amino acid metabolism (HP:0010894)2.38700124
64Abnormality of glycine metabolism (HP:0010895)2.38700124
65Optic disc pallor (HP:0000543)2.38622693
66Palpitations (HP:0001962)2.37380476
67Emotional lability (HP:0000712)2.36304078
68Nephrogenic diabetes insipidus (HP:0009806)2.36018743
69Lipid accumulation in hepatocytes (HP:0006561)2.35645379
70Poor suck (HP:0002033)2.34685609
71Abnormality of urine glucose concentration (HP:0011016)2.33742067
72Glycosuria (HP:0003076)2.33742067
73Abnormal lung lobation (HP:0002101)2.33196450
74Abnormality of methionine metabolism (HP:0010901)2.32611260
75Gait imbalance (HP:0002141)2.32421259
76Increased IgM level (HP:0003496)2.32353989
77Hypoglycemic coma (HP:0001325)2.25839780
78Megaloblastic anemia (HP:0001889)2.24259655
79Abnormality of glycolipid metabolism (HP:0010969)2.22979840
80Abnormality of liposaccharide metabolism (HP:0010968)2.22979840
81Abnormality of glycosphingolipid metabolism (HP:0004343)2.22979840
82Cerebral hypomyelination (HP:0006808)2.22130011
83Posterior subcapsular cataract (HP:0007787)2.21689580
84Elevated erythrocyte sedimentation rate (HP:0003565)2.21636780
85Hyperactive renin-angiotensin system (HP:0000841)2.21452089
86Abnormal hemoglobin (HP:0011902)2.19082163
87Leukodystrophy (HP:0002415)2.17816848
88Limb dystonia (HP:0002451)2.16857990
89Tongue fasciculations (HP:0001308)2.16604610
90Nausea (HP:0002018)2.15593896
91Lethargy (HP:0001254)2.14449722
92Generalized aminoaciduria (HP:0002909)2.13991807
93Cerebral edema (HP:0002181)2.13569454
94Intestinal atresia (HP:0011100)2.12952732
95Neoplasm of the colon (HP:0100273)2.12893563
96Fat malabsorption (HP:0002630)2.11663867
97Multiple enchondromatosis (HP:0005701)2.11496775
98Aplastic anemia (HP:0001915)2.11213208
99Breast carcinoma (HP:0003002)2.11100399
100Abnormality of the anterior horn cell (HP:0006802)2.10168845
101Degeneration of anterior horn cells (HP:0002398)2.10168845
102Increased intramyocellular lipid droplets (HP:0012240)2.08677474
103Poor head control (HP:0002421)2.07112920
104Horizontal nystagmus (HP:0000666)2.06298455
105Aplasia/Hypoplasia of the fovea (HP:0008060)2.05886482
106Hypoplasia of the fovea (HP:0007750)2.05886482
107Exertional dyspnea (HP:0002875)2.05293427
108Rhabdomyosarcoma (HP:0002859)2.04699505
109Inability to walk (HP:0002540)2.02629068
110Myokymia (HP:0002411)2.02509745
111Ependymoma (HP:0002888)2.01372123
112Generalized tonic-clonic seizures (HP:0002069)2.01114760
113Hypobetalipoproteinemia (HP:0003563)2.00649042
114X-linked dominant inheritance (HP:0001423)1.98859518
115Abnormality of chromosome stability (HP:0003220)1.98666450
116Dicarboxylic aciduria (HP:0003215)1.98564230
117Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98564230
118Ovarian neoplasm (HP:0100615)1.98539985
119Hyperglycinuria (HP:0003108)1.96543092
120Steatorrhea (HP:0002570)1.95220061
121Respiratory difficulties (HP:0002880)1.93706755
122Generalized hypotonia (HP:0001290)1.93451440
123Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91943286
124Cortical visual impairment (HP:0100704)1.91658921
125Upper limb muscle weakness (HP:0003484)1.90770899
126Meckel diverticulum (HP:0002245)1.90282772
127Renal cortical cysts (HP:0000803)1.90140138
128Recurrent abscess formation (HP:0002722)1.87926324
129Amblyopia (HP:0000646)1.87681906
130Abnormality of placental membranes (HP:0011409)1.85864895
131Amniotic constriction ring (HP:0009775)1.85864895
132Abnormality of sulfur amino acid metabolism (HP:0004339)1.85655595
133Short tibia (HP:0005736)1.85527027
134Supernumerary spleens (HP:0009799)1.85428227
135Abnormality of the preputium (HP:0100587)1.85233227
136CNS demyelination (HP:0007305)1.84136557
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82465036
138Muscle fibrillation (HP:0010546)1.82449412
139Biliary tract neoplasm (HP:0100574)1.82087932
140Duodenal stenosis (HP:0100867)1.81097886
141Small intestinal stenosis (HP:0012848)1.81097886
142Abnormality of the labia (HP:0000058)1.80430523
143Visual hallucinations (HP:0002367)1.80042023
144Hydroxyprolinuria (HP:0003080)1.78137267
145Abnormality of proline metabolism (HP:0010907)1.78137267
146Delusions (HP:0000746)1.77561503
147Bradycardia (HP:0001662)1.77156878
148Symptomatic seizures (HP:0011145)1.77042865
149Hypoplastic female external genitalia (HP:0012815)1.76655965
150Gonadotropin excess (HP:0000837)1.76205486
151Agnosia (HP:0010524)1.74167990
152Aplasia/Hypoplasia of the uvula (HP:0010293)1.74165968
153Labial hypoplasia (HP:0000066)1.71845605
154Abnormality of the duodenum (HP:0002246)1.71031497
155Abnormality of the ileum (HP:0001549)1.70781918
156Sparse eyelashes (HP:0000653)1.70411315
157Broad foot (HP:0001769)1.70395785
158Dyschromatopsia (HP:0007641)1.69690775
159Oral leukoplakia (HP:0002745)1.69605008
160Hypokinesia (HP:0002375)1.69313903
161Esotropia (HP:0000565)1.69310517
162Thyroid carcinoma (HP:0002890)1.67918067
163Papillary thyroid carcinoma (HP:0002895)1.67707553
164Nasolacrimal duct obstruction (HP:0000579)1.67578793
165Abnormality of the fovea (HP:0000493)1.67552647
166Single umbilical artery (HP:0001195)1.67174092
167Progressive inability to walk (HP:0002505)1.67120329
168Dysautonomia (HP:0002459)1.65672805
169Myositis (HP:0100614)1.65136338
170Resting tremor (HP:0002322)1.64637249
171Vertebral compression fractures (HP:0002953)1.63793643
172Polyphagia (HP:0002591)1.62761380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.59403807
2CASK4.21690635
3TRIM283.84907608
4GRK53.83892198
5ADRBK23.31816170
6CDK192.56063855
7SRPK12.46626341
8EIF2AK12.43786831
9NEK12.32562093
10TTK2.22561398
11GRK62.22540354
12RIPK42.14254607
13PLK32.11773275
14NUAK12.05388098
15STK162.03575477
16MKNK22.01531158
17MST41.98881329
18NTRK31.97751777
19GRK71.92227791
20NME11.86976862
21PLK41.78898610
22MAP4K21.72428128
23GRK11.69482497
24FRK1.68683379
25MAP2K71.67492630
26PIM21.66532060
27BRSK21.66087533
28ZAK1.65296488
29STK391.64453475
30CSF1R1.63110323
31SIK31.53265079
32NME21.50941356
33MATK1.49971841
34VRK21.49456608
35MKNK11.49356387
36AKT31.46418394
37BMPR21.44377749
38STK241.44263889
39BUB11.39029914
40EIF2AK31.38633595
41TNIK1.35348539
42ARAF1.31064999
43ADRBK11.29073977
44BMPR1B1.28509021
45BLK1.28487888
46FES1.27754242
47DAPK11.24542999
48PLK21.21518285
49MYLK1.21105562
50STK38L1.19243616
51MAP2K41.13265679
52MOS1.12635509
53TAF11.12408793
54TSSK61.11514045
55PLK11.09824509
56LIMK11.09230927
57CDC71.09026601
58CDK81.05889754
59MST1R1.03313942
60PRKG21.01243476
61NTRK10.94282396
62OXSR10.92119460
63WEE10.91688563
64TESK20.91441398
65CSNK1G10.88113494
66PTK2B0.86808237
67EPHA20.82019742
68TXK0.81545012
69PRPF4B0.81338611
70CSNK1G30.79186728
71MINK10.76436095
72PIK3CA0.76296900
73CSNK1G20.76234028
74PBK0.75131232
75TLK10.75084059
76WNK10.74951883
77BCR0.73298634
78VRK10.70370883
79PRKCI0.69834984
80ACVR1B0.69402806
81ERN10.68731790
82SYK0.68517952
83STK30.67835706
84PRKCG0.66721170
85IRAK30.64741115
86EIF2AK20.64207936
87TEC0.63376109
88SCYL20.63040230
89PDK30.62781594
90PDK40.62781594
91CAMK2B0.62205994
92BRSK10.60847216
93TNK20.60786857
94TESK10.60757824
95CCNB10.60565891
96CDK140.60489763
97KIT0.60059560
98DYRK30.59883652
99PRKCE0.57815539
100MAP3K40.57787903
101CDK180.57374470
102TGFBR20.56146974
103MAPKAPK50.55169243
104MUSK0.54877222
105PAK40.54523647
106YES10.54468819
107CAMKK20.54153819
108MET0.53871765
109FGFR20.53364516
110ERBB40.52776839
111PRKCD0.52370721
112CAMK2A0.51706987
113NEK60.51163111
114CDK150.50711880
115NEK90.50314915
116ERBB30.50086009
117IKBKB0.48906718
118CSNK1A1L0.48850322
119MAPK70.48696096
120FGFR10.46501721
121FER0.46361214
122RPS6KA40.45688813
123BCKDK0.45097570
124CDK11A0.44925399
125DAPK30.43771381
126MAP2K60.43633719
127AURKB0.43125987
128MAP3K90.42915495
129EPHA40.42882460
130LMTK20.41535422
131LYN0.41520956
132KSR10.41103748
133KDR0.40705605
134ATR0.40431553
135PAK30.40262204
136MAPK130.39895814
137CAMK40.39060473
138CSNK2A10.36965583
139FGR0.36798611
140ABL20.36020355
141LCK0.35635946
142TGFBR10.35605575
143IRAK40.35137132
144CDK90.34656868
145WNK30.34397102
146ATM0.34384671
147CHEK20.33226211
148DYRK20.33197554
149CAMK2D0.32889938
150PDK20.32792226
151CDK50.32622699
152BRAF0.32108090
153CSNK1A10.31009037
154CSNK2A20.30853282
155PNCK0.29531882
156MAP3K50.29359400
157PASK0.27137192
158RPS6KA50.26319541

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.44835679
2Collecting duct acid secretion_Homo sapiens_hsa049663.57615769
3Proteasome_Homo sapiens_hsa030503.50130256
4Parkinsons disease_Homo sapiens_hsa050123.41785460
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.85552447
6Ribosome_Homo sapiens_hsa030102.81639440
7Protein export_Homo sapiens_hsa030602.76482686
8Synaptic vesicle cycle_Homo sapiens_hsa047212.73377688
9Alzheimers disease_Homo sapiens_hsa050102.61883710
10Vibrio cholerae infection_Homo sapiens_hsa051102.52788206
11Mismatch repair_Homo sapiens_hsa034302.28347845
12Non-homologous end-joining_Homo sapiens_hsa034502.25737913
13Huntingtons disease_Homo sapiens_hsa050162.24615403
14Rheumatoid arthritis_Homo sapiens_hsa053232.11208907
15Propanoate metabolism_Homo sapiens_hsa006402.07716141
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.93546105
17Nicotine addiction_Homo sapiens_hsa050331.91963746
18Caffeine metabolism_Homo sapiens_hsa002321.87005539
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.82732110
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73263221
21Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.69323324
22Vitamin B6 metabolism_Homo sapiens_hsa007501.68021685
23Fat digestion and absorption_Homo sapiens_hsa049751.66178125
24Folate biosynthesis_Homo sapiens_hsa007901.64973481
25Phagosome_Homo sapiens_hsa041451.64077145
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62822827
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60391382
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58633196
29RNA polymerase_Homo sapiens_hsa030201.55667925
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53589281
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52134461
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.51257846
33DNA replication_Homo sapiens_hsa030301.48761228
34Vitamin digestion and absorption_Homo sapiens_hsa049771.43635740
35Steroid biosynthesis_Homo sapiens_hsa001001.37509125
36RNA degradation_Homo sapiens_hsa030181.37183551
37Serotonergic synapse_Homo sapiens_hsa047261.35881928
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34959095
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33243553
40GABAergic synapse_Homo sapiens_hsa047271.26886776
41Pyruvate metabolism_Homo sapiens_hsa006201.25644587
42Arginine biosynthesis_Homo sapiens_hsa002201.24751628
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22732935
44Regulation of autophagy_Homo sapiens_hsa041401.21830588
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20052284
46Cardiac muscle contraction_Homo sapiens_hsa042601.19425562
47Retinol metabolism_Homo sapiens_hsa008301.19325691
48RNA transport_Homo sapiens_hsa030131.17295457
49Cell cycle_Homo sapiens_hsa041101.14423468
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.14258921
51Nucleotide excision repair_Homo sapiens_hsa034201.13158658
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.13027140
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12348563
54Glutathione metabolism_Homo sapiens_hsa004801.11814940
55Peroxisome_Homo sapiens_hsa041461.10686135
56Butanoate metabolism_Homo sapiens_hsa006501.08937033
57Taste transduction_Homo sapiens_hsa047421.08881150
58Morphine addiction_Homo sapiens_hsa050321.08131082
59Type I diabetes mellitus_Homo sapiens_hsa049401.08071365
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07012080
61Fanconi anemia pathway_Homo sapiens_hsa034601.06374666
62Fructose and mannose metabolism_Homo sapiens_hsa000511.05653078
63Drug metabolism - other enzymes_Homo sapiens_hsa009831.05310600
64Base excision repair_Homo sapiens_hsa034101.03599588
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02887487
66One carbon pool by folate_Homo sapiens_hsa006701.02781036
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01715798
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00726020
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99887284
70Selenocompound metabolism_Homo sapiens_hsa004500.99426371
71Arachidonic acid metabolism_Homo sapiens_hsa005900.99411407
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97230299
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97183181
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96455540
75Mineral absorption_Homo sapiens_hsa049780.96225316
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96090257
77Nitrogen metabolism_Homo sapiens_hsa009100.95910780
78Fatty acid degradation_Homo sapiens_hsa000710.95221423
79Circadian entrainment_Homo sapiens_hsa047130.95220727
80Chemical carcinogenesis_Homo sapiens_hsa052040.93821442
81Starch and sucrose metabolism_Homo sapiens_hsa005000.92872786
82Oocyte meiosis_Homo sapiens_hsa041140.91147622
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90930727
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90320168
85Sphingolipid metabolism_Homo sapiens_hsa006000.89804364
86Spliceosome_Homo sapiens_hsa030400.89025290
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87826029
88Tryptophan metabolism_Homo sapiens_hsa003800.87359811
89Glutamatergic synapse_Homo sapiens_hsa047240.85323986
90Basal transcription factors_Homo sapiens_hsa030220.85001247
91Carbon metabolism_Homo sapiens_hsa012000.84863184
92Other glycan degradation_Homo sapiens_hsa005110.84851258
93Graft-versus-host disease_Homo sapiens_hsa053320.84770092
94Arginine and proline metabolism_Homo sapiens_hsa003300.84569931
95Fatty acid metabolism_Homo sapiens_hsa012120.84225569
96Olfactory transduction_Homo sapiens_hsa047400.83969650
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.83905608
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83549171
99Long-term depression_Homo sapiens_hsa047300.82881570
100Dopaminergic synapse_Homo sapiens_hsa047280.82862510
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82597572
102Long-term potentiation_Homo sapiens_hsa047200.82466911
103Legionellosis_Homo sapiens_hsa051340.81374382
104Allograft rejection_Homo sapiens_hsa053300.81030566
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.80055251
106Amphetamine addiction_Homo sapiens_hsa050310.78966967
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75719290
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75695153
109Renin-angiotensin system_Homo sapiens_hsa046140.72931914
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.72791773
111Pertussis_Homo sapiens_hsa051330.71314478
112Ether lipid metabolism_Homo sapiens_hsa005650.70490685
113Tuberculosis_Homo sapiens_hsa051520.67666475
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66983479
115Lysosome_Homo sapiens_hsa041420.66228043
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.65668706
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65627446
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64407295
119Hematopoietic cell lineage_Homo sapiens_hsa046400.63568173
120p53 signaling pathway_Homo sapiens_hsa041150.63495567
121Galactose metabolism_Homo sapiens_hsa000520.62245045
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61648690
123African trypanosomiasis_Homo sapiens_hsa051430.60254453
124Calcium signaling pathway_Homo sapiens_hsa040200.57946356
125Fatty acid elongation_Homo sapiens_hsa000620.57556843
126Pyrimidine metabolism_Homo sapiens_hsa002400.56234030
127beta-Alanine metabolism_Homo sapiens_hsa004100.54251832
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53824429
129Leishmaniasis_Homo sapiens_hsa051400.53750428
130Biosynthesis of amino acids_Homo sapiens_hsa012300.52286469
131Histidine metabolism_Homo sapiens_hsa003400.52246969
132Primary immunodeficiency_Homo sapiens_hsa053400.52113456
133Purine metabolism_Homo sapiens_hsa002300.49305210
134Asthma_Homo sapiens_hsa053100.48696273
135Phototransduction_Homo sapiens_hsa047440.48547153
136Salmonella infection_Homo sapiens_hsa051320.46472932
137Cocaine addiction_Homo sapiens_hsa050300.45892392
138Malaria_Homo sapiens_hsa051440.43309847
139Pentose phosphate pathway_Homo sapiens_hsa000300.42030601
140Metabolic pathways_Homo sapiens_hsa011000.41693609
141Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41063429
142mRNA surveillance pathway_Homo sapiens_hsa030150.39586630
143Autoimmune thyroid disease_Homo sapiens_hsa053200.38878932
144Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38747651
145Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38405910
146Renin secretion_Homo sapiens_hsa049240.38097286
147Salivary secretion_Homo sapiens_hsa049700.37527814
148Thyroid cancer_Homo sapiens_hsa052160.36686978
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35826704
150Protein digestion and absorption_Homo sapiens_hsa049740.34893964
151Cholinergic synapse_Homo sapiens_hsa047250.34854775
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34370756
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.32799515
154Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32624559
155Shigellosis_Homo sapiens_hsa051310.32451567
156Linoleic acid metabolism_Homo sapiens_hsa005910.30689202
157Inositol phosphate metabolism_Homo sapiens_hsa005620.29889287
158Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29693111
159Ras signaling pathway_Homo sapiens_hsa040140.28814423
160Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28801202
161Insulin secretion_Homo sapiens_hsa049110.28444804
162Sulfur metabolism_Homo sapiens_hsa009200.26094736
163Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25349402
164Homologous recombination_Homo sapiens_hsa034400.23613709
165Vascular smooth muscle contraction_Homo sapiens_hsa042700.23567209

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