GSN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)5.44644789
2keratan sulfate catabolic process (GO:0042340)5.32872537
3peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.18863708
4protein heterotrimerization (GO:0070208)5.15801828
5retina vasculature morphogenesis in camera-type eye (GO:0061299)4.77633745
6extracellular matrix assembly (GO:0085029)4.47926527
7blood vessel maturation (GO:0001955)4.32418564
8complement activation, alternative pathway (GO:0006957)4.11127657
9regulation of sequestering of triglyceride (GO:0010889)4.01931589
10positive regulation of macrophage cytokine production (GO:0060907)3.85143894
11peripheral nervous system axon ensheathment (GO:0032292)3.68985015
12myelination in peripheral nervous system (GO:0022011)3.68985015
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.66579795
14glomerular filtration (GO:0003094)3.60991019
15extracellular fibril organization (GO:0043206)3.52851997
16negative regulation of complement activation (GO:0045916)3.51312507
17triglyceride catabolic process (GO:0019433)3.43673482
18lipid particle organization (GO:0034389)3.41300118
19glomerular basement membrane development (GO:0032836)3.38187055
20renal filtration (GO:0097205)3.37164348
21adhesion of symbiont to host cell (GO:0044650)3.36641746
22virion attachment to host cell (GO:0019062)3.36641746
23collagen fibril organization (GO:0030199)3.33568656
24positive regulation of fatty acid oxidation (GO:0046321)3.28866834
25regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.23684269
26negative regulation of protein autophosphorylation (GO:0031953)3.21606761
27brown fat cell differentiation (GO:0050873)3.20524883
28membrane raft organization (GO:0031579)3.17698426
29creatine metabolic process (GO:0006600)3.15882733
30negative regulation of Rho protein signal transduction (GO:0035024)3.13728530
31cellular response to nitric oxide (GO:0071732)3.13325747
32* barbed-end actin filament capping (GO:0051016)3.11858405
33white fat cell differentiation (GO:0050872)3.10479805
34positive regulation of cholesterol efflux (GO:0010875)3.06411348
35positive regulation of p38MAPK cascade (GO:1900745)3.05256608
36regulation of endothelial cell differentiation (GO:0045601)3.03157123
37adhesion of symbiont to host (GO:0044406)3.01820789
38ovulation from ovarian follicle (GO:0001542)3.01350552
39positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.01327112
40regulation of macrophage cytokine production (GO:0010935)2.99504092
41acylglycerol catabolic process (GO:0046464)2.98519486
42neutral lipid catabolic process (GO:0046461)2.98519486
43fibril organization (GO:0097435)2.98289892
44transcytosis (GO:0045056)2.98149074
45cellular response to thyroid hormone stimulus (GO:0097067)2.97090942
46growth hormone receptor signaling pathway (GO:0060396)2.95707369
47import into cell (GO:0098657)2.95606669
48apoptotic cell clearance (GO:0043277)2.95141431
49basement membrane organization (GO:0071711)2.93041851
50endothelial cell morphogenesis (GO:0001886)2.92943149
51vascular endothelial growth factor signaling pathway (GO:0038084)2.90355387
52multicellular organismal macromolecule metabolic process (GO:0044259)2.88333326
53collagen metabolic process (GO:0032963)2.88106666
54positive regulation of lipoprotein lipase activity (GO:0051006)2.87978668
55positive regulation of triglyceride lipase activity (GO:0061365)2.87978668
56dermatan sulfate biosynthetic process (GO:0030208)2.87021169
57positive regulation of receptor recycling (GO:0001921)2.86875781
58fatty acid transmembrane transport (GO:1902001)2.84834238
59regulation of complement activation (GO:0030449)2.84135302
60long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.83651228
61positive regulation of endothelial cell differentiation (GO:0045603)2.81893348
62regulation of cholesterol storage (GO:0010885)2.81738253
63long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.80641594
64regulation of p38MAPK cascade (GO:1900744)2.80447083
65opsonization (GO:0008228)2.79952491
66multicellular organismal metabolic process (GO:0044236)2.79866962
67negative regulation of stress fiber assembly (GO:0051497)2.79825542
68fatty-acyl-CoA biosynthetic process (GO:0046949)2.79700331
69collagen catabolic process (GO:0030574)2.79686611
70cellular response to epinephrine stimulus (GO:0071872)2.78306252
71fatty-acyl-CoA metabolic process (GO:0035337)2.77992558
72negative regulation of protein activation cascade (GO:2000258)2.75949113
73positive regulation of fatty acid beta-oxidation (GO:0032000)2.73077083
74valine metabolic process (GO:0006573)2.72450105
75negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.71442778
76biotin metabolic process (GO:0006768)2.70996713
77triglyceride biosynthetic process (GO:0019432)2.69322889
78positive regulation of glycogen biosynthetic process (GO:0045725)2.68908689
79multicellular organismal catabolic process (GO:0044243)2.67609895
80bone trabecula formation (GO:0060346)2.66622159
81pinocytosis (GO:0006907)2.65020169
82stress fiber assembly (GO:0043149)2.64882258
83negative regulation of granulocyte differentiation (GO:0030853)2.64656780
84positive regulation of glucose import (GO:0046326)2.64237311
85dermatan sulfate metabolic process (GO:0030205)2.61655364
86regulation of membrane protein ectodomain proteolysis (GO:0051043)2.60836093
87cGMP-mediated signaling (GO:0019934)2.60598061
88positive regulation of sterol transport (GO:0032373)2.60588458
89positive regulation of cholesterol transport (GO:0032376)2.60588458
90cellular response to growth hormone stimulus (GO:0071378)2.59522260
91neutral lipid biosynthetic process (GO:0046460)2.58916164
92acylglycerol biosynthetic process (GO:0046463)2.58916164
93negative regulation of smooth muscle cell migration (GO:0014912)2.58755815
94plasma lipoprotein particle clearance (GO:0034381)2.58467166
95protein localization to endosome (GO:0036010)2.57847273
96thioester biosynthetic process (GO:0035384)2.56973870
97acyl-CoA biosynthetic process (GO:0071616)2.56973870
98regulation of macrophage chemotaxis (GO:0010758)2.56606967
99negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.56570201
100positive regulation of cellular response to insulin stimulus (GO:1900078)2.55638755
101response to nitric oxide (GO:0071731)2.55496469
102NADH metabolic process (GO:0006734)2.54923503
103regulation of vasculogenesis (GO:2001212)2.54836329
104regulation of mononuclear cell migration (GO:0071675)2.54393560
105cell migration involved in heart development (GO:0060973)2.54279711
106negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.53291123
107positive regulation of extracellular matrix organization (GO:1903055)2.53154899
108peptidyl-tyrosine autophosphorylation (GO:0038083)2.52793873
109regulation of macrophage derived foam cell differentiation (GO:0010743)2.52632639
110regulation of fatty acid oxidation (GO:0046320)2.52155314
111sulfur compound catabolic process (GO:0044273)2.51891878
112cellular response to reactive nitrogen species (GO:1902170)2.51394188
113mannose metabolic process (GO:0006013)2.50825617
114epithelial cell-cell adhesion (GO:0090136)2.50489618
115regulation of protein activation cascade (GO:2000257)2.49410304
116regulation of integrin-mediated signaling pathway (GO:2001044)2.48509265
117lymph vessel development (GO:0001945)2.48337972
118response to dietary excess (GO:0002021)2.48219861
119extracellular matrix disassembly (GO:0022617)2.47222417
120negative regulation of smooth muscle cell proliferation (GO:0048662)2.47174351
121lymphangiogenesis (GO:0001946)2.46381913
122axon ensheathment (GO:0008366)2.44903396
123ensheathment of neurons (GO:0007272)2.44903396
124lipid storage (GO:0019915)2.44793572
125positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.44688589
126regulation of apoptotic cell clearance (GO:2000425)2.44055857
127negative regulation of nitric oxide biosynthetic process (GO:0045019)2.43641951
128negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.43333074
129endothelium development (GO:0003158)2.42776352
130regulation of lipoprotein metabolic process (GO:0050746)2.42684435
131positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.42540184
132cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.41991852
133polyol transport (GO:0015791)2.36116901
134angiogenesis involved in wound healing (GO:0060055)2.35980918
135ethanol oxidation (GO:0006069)2.35934355
136positive regulation of lipid storage (GO:0010884)2.32379837
137positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.32064941
138response to thyroid hormone (GO:0097066)2.31632343
139response to epinephrine (GO:0071871)2.29512577
140glycosphingolipid catabolic process (GO:0046479)2.28490707
141positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.26831743
142regulation of extracellular matrix disassembly (GO:0010715)2.24735208
143cortical actin cytoskeleton organization (GO:0030866)2.22286807
144positive regulation of cellular amide metabolic process (GO:0034250)2.22209574
145cell volume homeostasis (GO:0006884)2.19045191
146positive regulation of endothelial cell apoptotic process (GO:2000353)2.16873195
147glycerolipid catabolic process (GO:0046503)2.15893268
148triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.14493085
149negative regulation of platelet activation (GO:0010544)2.13631703
150regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.12244142
151negative regulation of erythrocyte differentiation (GO:0045647)2.12162659
152surfactant homeostasis (GO:0043129)2.11657755
153regulation of cholesterol esterification (GO:0010872)2.10099057
154peptide catabolic process (GO:0043171)2.07150982
155cortical cytoskeleton organization (GO:0030865)2.06514574
156oligosaccharide catabolic process (GO:0009313)2.04529107
157ethanol metabolic process (GO:0006067)2.03146407
158cell-substrate junction assembly (GO:0007044)2.02601038
159glycolipid catabolic process (GO:0019377)2.02265563
160negative regulation of protein localization to plasma membrane (GO:1903077)2.02079147
161glial cell migration (GO:0008347)2.01659474
162regulation of cholesterol efflux (GO:0010874)2.01655998
163low-density lipoprotein particle remodeling (GO:0034374)2.00515138
164endodermal cell differentiation (GO:0035987)1.98851668
165negative regulation of adherens junction organization (GO:1903392)1.98766944
166negative regulation of focal adhesion assembly (GO:0051895)1.98766944
167negative regulation of cell junction assembly (GO:1901889)1.98766944
168negative regulation of lipid storage (GO:0010888)1.98295381

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.29016497
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.38212023
3GATA1_22025678_ChIP-Seq_K562_Human3.62236564
4CLOCK_20551151_ChIP-Seq_293T_Human3.55568794
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.07111431
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.98503501
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.70170773
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.64919671
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.50488277
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.33498427
11* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.31546730
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.03659991
13EP300_21415370_ChIP-Seq_HL-1_Mouse2.01820094
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.89523246
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.87711421
16* CJUN_26792858_Chip-Seq_BT549_Human1.87442802
17GATA2_21666600_ChIP-Seq_HMVEC_Human1.83815660
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.82781937
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62801011
20BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.61961220
21PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59138584
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.56858281
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51530496
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48043742
25* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.47161150
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.45435752
27* TBX20_22080862_ChIP-Seq_HEART_Mouse1.45339373
28* TBX20_22328084_ChIP-Seq_HEART_Mouse1.45339373
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.44552301
30* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44459374
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42000226
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40673860
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40648381
34NFIB_24661679_ChIP-Seq_LUNG_Mouse1.37806356
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.37398371
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36541588
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36541588
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.36460377
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36087870
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36087870
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35661222
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.33140943
43AR_21572438_ChIP-Seq_LNCaP_Human1.32329735
44P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32201217
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30694423
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.29609391
47* SOX2_20726797_ChIP-Seq_SW620_Human1.28779858
48* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27577119
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26809115
50EED_16625203_ChIP-ChIP_MESCs_Mouse1.25016926
51RXR_22158963_ChIP-Seq_LIVER_Mouse1.18328347
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18032442
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17959374
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17769046
55* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.16112229
56* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15472045
57DROSHA_22980978_ChIP-Seq_HELA_Human1.15063568
58* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14354408
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14109903
60* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14085089
61* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13602476
62ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13432107
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09821072
64SPI1_23127762_ChIP-Seq_K562_Human1.09629511
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.09145929
66* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.08086456
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07950902
68* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07393257
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07372307
70AHR_22903824_ChIP-Seq_MCF-7_Human1.06929204
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06813896
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.06512899
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06454061
74* VDR_24763502_ChIP-Seq_THP-1_Human1.05555903
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05300011
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05011915
77GATA1_19941826_ChIP-Seq_K562_Human1.03070661
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02925905
79* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01709238
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01413758
81KDM2B_26808549_Chip-Seq_DND41_Human1.00545579
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.00297887
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99837083
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99510403
85SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97863114
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97789969
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97520934
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96793308
89ERG_21242973_ChIP-ChIP_JURKAT_Human0.96564289
90* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96423026
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96333044
92* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95018712
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94811710
94VDR_24787735_ChIP-Seq_THP-1_Human0.94298195
95TCF7_22412390_ChIP-Seq_EML_Mouse0.94285380
96BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93928149
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93672290
98P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93522890
99RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93272571
100TP53_18474530_ChIP-ChIP_U2OS_Human0.93239010
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92963243
102* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92803671
103* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92676797
104* RACK7_27058665_Chip-Seq_MCF-7_Human0.92465380
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92434066
106* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90925609
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90294402
108JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90288273
109THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90275364
110* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89521676
111* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89169984
112SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88650014
113PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88419362
114KDM2B_26808549_Chip-Seq_K562_Human0.88184541
115* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88105065
116ZNF263_19887448_ChIP-Seq_K562_Human0.87204412
117* SMC4_20622854_ChIP-Seq_HELA_Human0.86365302
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86329190
119* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84731877
120KLF5_25053715_ChIP-Seq_YYC3_Human0.84573575
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83966733
122LXR_22292898_ChIP-Seq_THP-1_Human0.83512069
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83364218
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82965966
125CSB_26484114_Chip-Seq_FIBROBLAST_Human0.82582193
126* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81081697
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80662871
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.80544704
129BRD4_25478319_ChIP-Seq_HGPS_Human0.80309586
130* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80276865
131ARNT_22903824_ChIP-Seq_MCF-7_Human0.79854413
132* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79383454
133* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79383454
134FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.78002032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.13429595
2MP0005275_abnormal_skin_tensile6.21639559
3MP0005503_abnormal_tendon_morphology4.91342356
4MP0005670_abnormal_white_adipose3.37810348
5MP0004272_abnormal_basement_membrane3.08181720
6MP0001958_emphysema3.06701306
7MP0000751_myopathy2.51527433
8MP0005666_abnormal_adipose_tissue2.51350849
9MP0009840_abnormal_foam_cell2.46193920
10MP0004130_abnormal_muscle_cell2.44911332
11MP0004185_abnormal_adipocyte_glucose2.44025657
12MP0003950_abnormal_plasma_membrane2.39034522
13MP0000013_abnormal_adipose_tissue2.27578658
14MP0005375_adipose_tissue_phenotype2.17403801
15MP0002837_dystrophic_cardiac_calcinosis2.15920044
16MP0003705_abnormal_hypodermis_morpholog2.08856485
17MP0003724_increased_susceptibility_to2.05779317
18MP0002108_abnormal_muscle_morphology1.97737140
19MP0002060_abnormal_skin_morphology1.92750418
20MP0010368_abnormal_lymphatic_system1.89811597
21MP0000003_abnormal_adipose_tissue1.82083580
22MP0003566_abnormal_cell_adhesion1.78298353
23MP0006054_spinal_hemorrhage1.73454317
24MP0001879_abnormal_lymphatic_vessel1.63799089
25MP0003279_aneurysm1.63516616
26MP0003303_peritoneal_inflammation1.59981823
27MP0001661_extended_life_span1.59379244
28MP0005257_abnormal_intraocular_pressure1.58397207
29MP0004510_myositis1.52494765
30MP0000604_amyloidosis1.50715026
31MP0000343_altered_response_to1.48975220
32MP0000749_muscle_degeneration1.47762810
33MP0003191_abnormal_cellular_cholesterol1.44634560
34MP0003011_delayed_dark_adaptation1.39665971
35MP0003690_abnormal_glial_cell1.36920448
36MP0006138_congestive_heart_failure1.34616480
37MP0006082_CNS_inflammation1.34203401
38MP0003329_amyloid_beta_deposits1.33905322
39MP0000750_abnormal_muscle_regeneration1.33396883
40MP0003828_pulmonary_edema1.33198309
41MP0003172_abnormal_lysosome_physiology1.32108886
42MP0002877_abnormal_melanocyte_morpholog1.30959402
43MP0003436_decreased_susceptibility_to1.30699695
44MP0000920_abnormal_myelination1.29295929
45* MP0005165_increased_susceptibility_to1.28345095
46MP0005409_darkened_coat_color1.28218125
47* MP0003075_altered_response_to1.28045644
48MP0002971_abnormal_brown_adipose1.26455938
49MP0004036_abnormal_muscle_relaxation1.21916621
50* MP0005508_abnormal_skeleton_morphology1.21341361
51MP0003300_gastrointestinal_ulcer1.20486031
52MP0003453_abnormal_keratinocyte_physiol1.18641222
53* MP0002295_abnormal_pulmonary_circulatio1.15773738
54MP0002933_joint_inflammation1.13068517
55MP0002896_abnormal_bone_mineralization1.10029495
56MP0004087_abnormal_muscle_fiber1.09773683
57MP0004084_abnormal_cardiac_muscle1.09415788
58MP0005330_cardiomyopathy1.08992006
59MP0005388_respiratory_system_phenotype1.08191358
60MP0002133_abnormal_respiratory_system1.08191358
61MP0002166_altered_tumor_susceptibility1.08027527
62MP0009115_abnormal_fat_cell1.07737099
63MP0000858_altered_metastatic_potential1.07642554
64MP0002796_impaired_skin_barrier1.06730082
65MP0005334_abnormal_fat_pad1.06647568
66* MP0002419_abnormal_innate_immunity1.05662599
67MP0005595_abnormal_vascular_smooth1.05268290
68MP0005385_cardiovascular_system_phenoty1.04678575
69MP0001544_abnormal_cardiovascular_syste1.04678575
70MP0003045_fibrosis1.04652890
71MP0005164_abnormal_response_to1.04431673
72MP0005620_abnormal_muscle_contractility1.01909933
73MP0009278_abnormal_bone_marrow1.01236743
74MP0004883_abnormal_blood_vessel1.01158752
75MP0009780_abnormal_chondrocyte_physiolo1.00893281
76MP0000759_abnormal_skeletal_muscle1.00393275
77MP0005369_muscle_phenotype0.98292007
78MP0001243_abnormal_dermal_layer0.96935234
79MP0002876_abnormal_thyroid_physiology0.96851747
80MP0005623_abnormal_meninges_morphology0.96051680
81MP0000747_muscle_weakness0.95903523
82MP0010329_abnormal_lipoprotein_level0.95054337
83MP0005166_decreased_susceptibility_to0.94606937
84MP0004858_abnormal_nervous_system0.93665521
85MP0008260_abnormal_autophagy0.93626365
86MP0002118_abnormal_lipid_homeostasis0.91852148
87MP0008004_abnormal_stomach_pH0.91088151
88MP0002972_abnormal_cardiac_muscle0.91024640
89MP0008775_abnormal_heart_ventricle0.90324909
90MP0000767_abnormal_smooth_muscle0.89369666
91MP0005451_abnormal_body_composition0.87595381
92MP0005397_hematopoietic_system_phenotyp0.87110405
93MP0001545_abnormal_hematopoietic_system0.87110405
94MP0002148_abnormal_hypersensitivity_rea0.84368440
95MP0000733_abnormal_muscle_development0.82409894
96* MP0005390_skeleton_phenotype0.80554681
97MP0004147_increased_porphyrin_level0.79824223
98MP0003959_abnormal_lean_body0.78877137
99MP0005058_abnormal_lysosome_morphology0.77314503
100MP0005025_abnormal_response_to0.77056271
101MP0009785_altered_susceptibility_to0.76304188
102MP0005167_abnormal_blood-brain_barrier0.76268912
103MP0003634_abnormal_glial_cell0.75779525
104* MP0000249_abnormal_blood_vessel0.75675003
105MP0003091_abnormal_cell_migration0.73978811
106* MP0001533_abnormal_skeleton_physiology0.73855112
107MP0002106_abnormal_muscle_physiology0.73434192
108MP0001756_abnormal_urination0.71715377
109MP0002970_abnormal_white_adipose0.70956827
110MP0003448_altered_tumor_morphology0.70822046
111MP0002138_abnormal_hepatobiliary_system0.68366162
112* MP0005023_abnormal_wound_healing0.68151784
113MP0004484_altered_response_of0.65643311
114MP0002006_tumorigenesis0.65056998
115MP0010771_integument_phenotype0.65039909
116MP0002128_abnormal_blood_circulation0.64507911
117MP0002168_other_aberrant_phenotype0.64254486
118MP0001614_abnormal_blood_vessel0.63683311
119MP0010630_abnormal_cardiac_muscle0.62397672
120MP0009384_cardiac_valve_regurgitation0.61690468
121MP0001177_atelectasis0.61147044
122MP0001175_abnormal_lung_morphology0.59298640
123MP0000230_abnormal_systemic_arterial0.58664655
124MP0001851_eye_inflammation0.57749197
125MP0004215_abnormal_myocardial_fiber0.56584391
126MP0001542_abnormal_bone_strength0.56058724
127MP0002254_reproductive_system_inflammat0.54078432
128MP0001727_abnormal_embryo_implantation0.53919974
129* MP0002998_abnormal_bone_remodeling0.51593227
130* MP0000163_abnormal_cartilage_morphology0.50275733
131MP0002090_abnormal_vision0.50199637

Predicted human phenotypes

RankGene SetZ-score
1Broad metatarsal (HP:0001783)5.90979600
2Protrusio acetabuli (HP:0003179)5.38497742
3Premature rupture of membranes (HP:0001788)5.28837787
4Ankle contracture (HP:0006466)5.23982936
5Muscle fiber splitting (HP:0003555)4.68458588
6Increased connective tissue (HP:0009025)4.55588755
7Acanthosis nigricans (HP:0000956)4.11609950
8Type 1 muscle fiber predominance (HP:0003803)4.03886131
9Complement deficiency (HP:0004431)4.03238451
10Abnormality of glycolipid metabolism (HP:0010969)3.89243800
11Abnormality of liposaccharide metabolism (HP:0010968)3.89243800
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.89243800
13Aortic dissection (HP:0002647)3.88731632
14Spinal rigidity (HP:0003306)3.73997911
15Wrist flexion contracture (HP:0001239)3.71334607
16Increased variability in muscle fiber diameter (HP:0003557)3.57706151
17Follicular hyperkeratosis (HP:0007502)3.50063416
18Cerebral aneurysm (HP:0004944)3.46124037
19Cervical subluxation (HP:0003308)3.44670364
20Dysostosis multiplex (HP:0000943)3.35847192
21Distal lower limb muscle weakness (HP:0009053)3.35672890
22Asymmetric septal hypertrophy (HP:0001670)3.33978814
23Right ventricular cardiomyopathy (HP:0011663)3.27212506
24Soft skin (HP:0000977)3.25939766
25Difficulty running (HP:0009046)3.19549366
26Shallow orbits (HP:0000586)3.17044274
27Myocardial infarction (HP:0001658)3.14152013
28Hyporeflexia of lower limbs (HP:0002600)3.14007870
29Round ear (HP:0100830)3.12658028
30Abnormality of skeletal muscle fiber size (HP:0012084)3.10451553
31Aortic aneurysm (HP:0004942)3.10255166
32Hematochezia (HP:0002573)3.07822983
33Systemic lupus erythematosus (HP:0002725)3.04628606
34Abnormality of complement system (HP:0005339)3.03733209
35Glomerulonephritis (HP:0000099)2.95904296
36Oligomenorrhea (HP:0000876)2.93314948
37Vacuolated lymphocytes (HP:0001922)2.86467801
38Spontaneous hematomas (HP:0007420)2.84128200
39Slender build (HP:0001533)2.81491999
40Polycythemia (HP:0001901)2.74005768
41Pulmonary artery stenosis (HP:0004415)2.70352447
42Bladder diverticulum (HP:0000015)2.68274055
43Urinary glycosaminoglycan excretion (HP:0003541)2.67914879
44Mucopolysacchariduria (HP:0008155)2.67914879
45Ileus (HP:0002595)2.67590068
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.66034127
47Abnormality of polysaccharide metabolism (HP:0011012)2.66034127
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.66034127
49Vertebral compression fractures (HP:0002953)2.54918066
50Osteolytic defects of the hand bones (HP:0009699)2.53544805
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.53544805
52Cerebral hemorrhage (HP:0001342)2.48620615
53Nuclear cataract (HP:0100018)2.46680158
54Distal lower limb amyotrophy (HP:0008944)2.42039484
55Atrophic scars (HP:0001075)2.40638363
56Mildly elevated creatine phosphokinase (HP:0008180)2.37571056
57Hypertriglyceridemia (HP:0002155)2.37373359
58Increased cerebral lipofuscin (HP:0011813)2.36410260
59Mitral valve prolapse (HP:0001634)2.35497039
60Dilatation of the ascending aorta (HP:0005111)2.35235967
61Xanthomatosis (HP:0000991)2.34267755
62Lipoatrophy (HP:0100578)2.32248073
63Bronchomalacia (HP:0002780)2.32010875
64Neonatal short-limb short stature (HP:0008921)2.31863440
65Neurofibrillary tangles (HP:0002185)2.30532275
66Wormian bones (HP:0002645)2.30466556
67Abnormality of the nasal mucosa (HP:0000433)2.29825182
68Growth hormone excess (HP:0000845)2.28513212
69Hypoplasia of the iris (HP:0007676)2.25473275
70Eczematoid dermatitis (HP:0000976)2.25255907
71Joint stiffness (HP:0001387)2.23559086
72Ventricular tachycardia (HP:0004756)2.21507525
73Reduced subcutaneous adipose tissue (HP:0003758)2.20053650
74Delayed closure of the anterior fontanelle (HP:0001476)2.18356149
75Hyperextensible skin (HP:0000974)2.11270995
76Vascular tortuosity (HP:0004948)2.09812547
77Purpura (HP:0000979)2.09719657
78Loss of speech (HP:0002371)2.09509799
79Disproportionate tall stature (HP:0001519)2.09174031
80Venous abnormality (HP:0002624)2.06926436
81Peritonitis (HP:0002586)2.06829089
82Stridor (HP:0010307)2.06650979
83Rectal prolapse (HP:0002035)2.06123420
84Nephritis (HP:0000123)2.04561950
85Abnormality of macrophages (HP:0004311)2.04367269
86Skin nodule (HP:0200036)2.02672506
87Premature skin wrinkling (HP:0100678)2.02499151
88Bundle branch block (HP:0011710)2.02394371
89Esophageal varix (HP:0002040)2.01715884
90Scapular winging (HP:0003691)2.00959520
91Recurrent gram-negative bacterial infections (HP:0005420)2.00004137
92Exercise-induced myalgia (HP:0003738)1.99223458
93Aneurysm (HP:0002617)1.99109203
94Myotonia (HP:0002486)1.98185552
95Fragile skin (HP:0001030)1.97804651
96Camptodactyly of toe (HP:0001836)1.96679077
97Blue sclerae (HP:0000592)1.96436676
98Centrally nucleated skeletal muscle fibers (HP:0003687)1.95490133
99Striae distensae (HP:0001065)1.94514684
100Venous insufficiency (HP:0005293)1.92945555
101Calf muscle hypertrophy (HP:0008981)1.92557931
102Bone cyst (HP:0012062)1.90626139
103Flat cornea (HP:0007720)1.89928882
104Mitral stenosis (HP:0001718)1.89204271
105Tarsal synostosis (HP:0008368)1.89097184
106Foot dorsiflexor weakness (HP:0009027)1.89022189
107Sudden death (HP:0001699)1.88999373
108Malnutrition (HP:0004395)1.88429118
109Bell-shaped thorax (HP:0001591)1.88412437
110Muscle hypertrophy of the lower extremities (HP:0008968)1.88398763
111Abnormality of the periventricular white matter (HP:0002518)1.87730067
112Arterial tortuosity (HP:0005116)1.86536105
113Axonal loss (HP:0003447)1.86449792
114Ovoid vertebral bodies (HP:0003300)1.86040107
115Neck muscle weakness (HP:0000467)1.84735286
116Gastrointestinal dysmotility (HP:0002579)1.83725910
117Increased neuronal autofluorescent lipopigment (HP:0002074)1.83575403
118Insulin-resistant diabetes mellitus (HP:0000831)1.82553206
119Joint laxity (HP:0001388)1.82372746
120Cerebral inclusion bodies (HP:0100314)1.81296697
121Hemorrhage of the eye (HP:0011885)1.80591902
122Muscle stiffness (HP:0003552)1.80486753
123Abnormal atrioventricular conduction (HP:0005150)1.78257919
124Generalized amyotrophy (HP:0003700)1.78171386
125J-shaped sella turcica (HP:0002680)1.78022239
126Thin bony cortex (HP:0002753)1.77642606
127EMG: myopathic abnormalities (HP:0003458)1.76758483
128Segmental peripheral demyelination/remyelination (HP:0003481)1.75809160
129Mutism (HP:0002300)1.75110307
130Thick nail (HP:0001805)1.74386301
131Hip contracture (HP:0003273)1.74356521
132Interstitial pulmonary disease (HP:0006530)1.74333614
133Joint hemorrhage (HP:0005261)1.74064383
134Abnormality of the foot musculature (HP:0001436)1.72894641
135Duplicated collecting system (HP:0000081)1.71834822
136Spondylolisthesis (HP:0003302)1.71815112
137Ulnar bowing (HP:0003031)1.71540381
138Visceral angiomatosis (HP:0100761)1.71330487
139Abnormality of the calf musculature (HP:0001430)1.70652915
140Broad ribs (HP:0000885)1.68626550
141Proximal amyotrophy (HP:0007126)1.68202320
142Hypoalphalipoproteinemia (HP:0003233)1.67554079
143Gingivitis (HP:0000230)1.67386406
144Gingival overgrowth (HP:0000212)1.67249081
145* Amyloidosis (HP:0011034)1.66838463
146Stroke (HP:0001297)1.65218772
147Ventricular arrhythmia (HP:0004308)1.64337122
148Atrial fibrillation (HP:0005110)1.63789246
149Short nail (HP:0001799)1.63775095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.72591418
2INSRR3.52121897
3TRIB33.49395008
4EPHB13.22606916
5TGFBR23.20324672
6TTN3.17754748
7CAMK1D2.95309094
8CAMK1G2.40549963
9MET2.31610967
10DDR22.22658015
11MYLK2.20941478
12ERN12.20328257
13PDGFRA2.19233960
14TESK12.13136779
15RIPK12.04607932
16SIK12.02303712
17TRPM72.01485972
18STK391.92754294
19MST1R1.90456003
20LMTK21.87136108
21EPHB21.72981591
22FGFR21.69219434
23EPHA31.68067154
24FER1.65689002
25BLK1.55184594
26CDC42BPA1.53693437
27BCKDK1.48576075
28MAPKAPK31.46209899
29FGFR41.41815618
30ABL21.32925616
31MAPKAPK51.29705441
32DMPK1.24675172
33PHKG21.22693473
34PHKG11.22693473
35TBK11.18515405
36BCR1.16680933
37PRKD11.15152684
38PRPF4B1.14735092
39NTRK11.11769558
40PRKCH1.09836160
41ZAP701.07731307
42PRKD21.06442115
43PKN11.05256781
44PDGFRB1.03654083
45PAK21.01207500
46PIK3CA0.99617876
47EEF2K0.97855915
48PRKD30.97707548
49MAP3K130.96534589
50PTK2B0.94473103
51JAK10.93646697
52ILK0.93463046
53ARAF0.93438226
54GRK70.91841753
55MAP3K110.91724594
56MAPK70.91546655
57ROCK20.91016041
58RIPK40.90913676
59PDK20.90019645
60OBSCN0.87015812
61PDK30.86990657
62PDK40.86990657
63EPHA20.86655089
64PTK60.85088374
65NME20.84987090
66MAP3K10.84181459
67OXSR10.83548885
68MAP3K30.83508105
69PRKAA20.83405498
70RPS6KA20.82835363
71IRAK30.80894553
72LATS10.80453290
73PINK10.79487067
74FGFR30.78860785
75WNK10.77995682
76FES0.77731340
77MAPK40.77656055
78LRRK20.77174152
79GSK3A0.75213260
80MAP3K140.69970237
81PRKG20.67194035
82PIM20.64190787
83ROCK10.63535393
84CAMK10.61775086
85KDR0.61455216
86PDPK10.61131047
87CAMK2G0.60416731
88BMX0.60098256
89PIK3CG0.59451119
90CAMKK20.59447330
91MAP2K10.58784844
92* CSK0.56656443
93PAK30.55763637
94RET0.55667704
95MUSK0.55355754
96MAPK150.54873759
97SGK30.54697922
98MAP2K30.54656049
99MAP2K20.54404505
100MOS0.53407586
101CSF1R0.53082802
102LIMK10.52916409
103JAK20.52608762
104WNK40.51465535
105RPS6KL10.51212200
106RPS6KC10.51212200
107KSR20.50645811
108DAPK30.49500210
109PDK10.48813541
110PTK20.48706094
111TAOK20.48003028
112MAP3K60.47182527
113PRKCE0.47155142
114GRK10.46706329
115HIPK20.46434794
116MARK20.45745386
117INSR0.45160339
118MAP3K70.44923294
119ICK0.44415212
120LATS20.42439352
121MAPK120.41066213
122IGF1R0.39574166
123TYK20.39373819
124CAMK2D0.37856322
125MAP3K20.36277093
126DAPK20.35781543
127* SRC0.34845612
128TGFBR10.34669590
129FRK0.34594332
130PAK60.33246559
131FGR0.32855178
132MAPKAPK20.32739429
133STK100.31630978
134MTOR0.31484137
135KIT0.31459959
136JAK30.31337854
137ABL10.30373293
138NEK90.29181718
139PAK40.28090659

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.45538003
2ECM-receptor interaction_Homo sapiens_hsa045123.13063371
3PPAR signaling pathway_Homo sapiens_hsa033202.68737743
4Propanoate metabolism_Homo sapiens_hsa006402.40860584
5Fatty acid biosynthesis_Homo sapiens_hsa000612.37267525
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18178910
7Fatty acid elongation_Homo sapiens_hsa000622.16480845
8Fatty acid metabolism_Homo sapiens_hsa012122.02395748
9Focal adhesion_Homo sapiens_hsa045101.98398117
10Caffeine metabolism_Homo sapiens_hsa002321.78769467
11Adipocytokine signaling pathway_Homo sapiens_hsa049201.65977586
12Malaria_Homo sapiens_hsa051441.64176837
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63283039
14Fatty acid degradation_Homo sapiens_hsa000711.60994773
15Staphylococcus aureus infection_Homo sapiens_hsa051501.59359650
16Protein digestion and absorption_Homo sapiens_hsa049741.56018557
17Glycerolipid metabolism_Homo sapiens_hsa005611.52090996
18Dilated cardiomyopathy_Homo sapiens_hsa054141.41445370
19Osteoclast differentiation_Homo sapiens_hsa043801.37218903
20Complement and coagulation cascades_Homo sapiens_hsa046101.36121362
21Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35337860
22Amoebiasis_Homo sapiens_hsa051461.24177794
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22084117
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21513267
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20678570
26AMPK signaling pathway_Homo sapiens_hsa041521.20017913
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17958561
28beta-Alanine metabolism_Homo sapiens_hsa004101.13399329
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08841979
30Insulin resistance_Homo sapiens_hsa049311.07675867
31Lysosome_Homo sapiens_hsa041421.07316170
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04761878
33Proteoglycans in cancer_Homo sapiens_hsa052051.03779075
34Leukocyte transendothelial migration_Homo sapiens_hsa046700.98422805
35Leishmaniasis_Homo sapiens_hsa051400.97419684
36Rheumatoid arthritis_Homo sapiens_hsa053230.94053820
37Vascular smooth muscle contraction_Homo sapiens_hsa042700.92133423
38PI3K-Akt signaling pathway_Homo sapiens_hsa041510.92132588
39Mineral absorption_Homo sapiens_hsa049780.91784927
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91592743
41Steroid biosynthesis_Homo sapiens_hsa001000.91478248
42Renin secretion_Homo sapiens_hsa049240.91405688
43Fat digestion and absorption_Homo sapiens_hsa049750.91185878
44Tuberculosis_Homo sapiens_hsa051520.91039866
45Pyruvate metabolism_Homo sapiens_hsa006200.90706173
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89274597
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84828089
48Arachidonic acid metabolism_Homo sapiens_hsa005900.84762689
49Prion diseases_Homo sapiens_hsa050200.84207222
50Viral myocarditis_Homo sapiens_hsa054160.82912151
51Pertussis_Homo sapiens_hsa051330.82854566
52Ovarian steroidogenesis_Homo sapiens_hsa049130.79912194
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78390717
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77194803
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76709150
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76574359
57Galactose metabolism_Homo sapiens_hsa000520.76120060
58Tight junction_Homo sapiens_hsa045300.76095980
59Toxoplasmosis_Homo sapiens_hsa051450.75558784
60Ether lipid metabolism_Homo sapiens_hsa005650.74478355
61TGF-beta signaling pathway_Homo sapiens_hsa043500.74259964
62Salmonella infection_Homo sapiens_hsa051320.73391400
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71862344
64TNF signaling pathway_Homo sapiens_hsa046680.71789359
65Nitrogen metabolism_Homo sapiens_hsa009100.71003375
66GnRH signaling pathway_Homo sapiens_hsa049120.70365306
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70350510
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70295565
69Glycosaminoglycan degradation_Homo sapiens_hsa005310.70136714
70Tryptophan metabolism_Homo sapiens_hsa003800.69480955
71Sulfur metabolism_Homo sapiens_hsa009200.69314825
72Adherens junction_Homo sapiens_hsa045200.68839781
73Butanoate metabolism_Homo sapiens_hsa006500.67725474
74Histidine metabolism_Homo sapiens_hsa003400.67496556
75Sphingolipid metabolism_Homo sapiens_hsa006000.66663745
76Small cell lung cancer_Homo sapiens_hsa052220.66396005
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66362131
78Vibrio cholerae infection_Homo sapiens_hsa051100.66161493
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66095132
80Vitamin B6 metabolism_Homo sapiens_hsa007500.65533211
81Notch signaling pathway_Homo sapiens_hsa043300.65013593
82Tyrosine metabolism_Homo sapiens_hsa003500.64509146
83Phenylalanine metabolism_Homo sapiens_hsa003600.64500768
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63908541
85Platelet activation_Homo sapiens_hsa046110.63435302
86Linoleic acid metabolism_Homo sapiens_hsa005910.62574097
87Acute myeloid leukemia_Homo sapiens_hsa052210.62083415
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61802794
89Insulin signaling pathway_Homo sapiens_hsa049100.61740202
90ABC transporters_Homo sapiens_hsa020100.60648877
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60562681
92Other glycan degradation_Homo sapiens_hsa005110.60274037
93Hematopoietic cell lineage_Homo sapiens_hsa046400.60243273
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.58632061
95Phagosome_Homo sapiens_hsa041450.58428640
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58018197
97Endocytosis_Homo sapiens_hsa041440.57779008
98Renal cell carcinoma_Homo sapiens_hsa052110.56941633
99Peroxisome_Homo sapiens_hsa041460.56464270
100* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56063953
101Fructose and mannose metabolism_Homo sapiens_hsa000510.54380264
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54159438
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54042990
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53163457
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.52976394
106Bile secretion_Homo sapiens_hsa049760.51522136
107Chemokine signaling pathway_Homo sapiens_hsa040620.49808344
108Type II diabetes mellitus_Homo sapiens_hsa049300.49654596
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49601738
110Axon guidance_Homo sapiens_hsa043600.49370059
111* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49294131
112Pathways in cancer_Homo sapiens_hsa052000.48975658
113VEGF signaling pathway_Homo sapiens_hsa043700.48738637
114Rap1 signaling pathway_Homo sapiens_hsa040150.48152248
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47842280
116Glutathione metabolism_Homo sapiens_hsa004800.47474990
117Hepatitis C_Homo sapiens_hsa051600.47031179
118Ras signaling pathway_Homo sapiens_hsa040140.46107707
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45834574
120Estrogen signaling pathway_Homo sapiens_hsa049150.45288122
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45109565
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44771941
123Renin-angiotensin system_Homo sapiens_hsa046140.44704950
124Bladder cancer_Homo sapiens_hsa052190.44069865
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42303872
126Chemical carcinogenesis_Homo sapiens_hsa052040.42099476
127Thyroid hormone synthesis_Homo sapiens_hsa049180.42053505
128Asthma_Homo sapiens_hsa053100.41829729
129Circadian rhythm_Homo sapiens_hsa047100.40909981
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39905632
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.39861822
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39769916
133Autoimmune thyroid disease_Homo sapiens_hsa053200.39046192
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.38156679
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.37810341
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37784434
137Carbon metabolism_Homo sapiens_hsa012000.37716244
138Dorso-ventral axis formation_Homo sapiens_hsa043200.36912360
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.33371122

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