GSPT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.68419414
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.54664502
3pyrimidine nucleobase catabolic process (GO:0006208)5.45751444
4vocalization behavior (GO:0071625)5.11767531
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.94545235
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.93863824
7neuron cell-cell adhesion (GO:0007158)4.92219776
8locomotory exploration behavior (GO:0035641)4.75486169
9synaptic vesicle exocytosis (GO:0016079)4.73107160
10protein localization to synapse (GO:0035418)4.66241656
11regulation of glutamate receptor signaling pathway (GO:1900449)4.53088229
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.38759133
13regulation of synaptic vesicle exocytosis (GO:2000300)4.31344173
14synaptic vesicle maturation (GO:0016188)4.30020496
15synaptic transmission, glutamatergic (GO:0035249)4.14592472
16nucleobase catabolic process (GO:0046113)4.12009671
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.09256363
18glutamate receptor signaling pathway (GO:0007215)4.07891966
19exploration behavior (GO:0035640)4.06171552
20regulation of synaptic vesicle transport (GO:1902803)4.01642639
21glutamate secretion (GO:0014047)3.97909991
22dendritic spine morphogenesis (GO:0060997)3.91416735
23neuron-neuron synaptic transmission (GO:0007270)3.90403105
24DNA double-strand break processing (GO:0000729)3.88557932
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.86829672
26neuron recognition (GO:0008038)3.85742401
27layer formation in cerebral cortex (GO:0021819)3.85285780
28regulation of neuronal synaptic plasticity (GO:0048168)3.85039878
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.83159102
30neurotransmitter secretion (GO:0007269)3.81640355
31positive regulation of synaptic transmission, GABAergic (GO:0032230)3.80425091
32DNA damage response, detection of DNA damage (GO:0042769)3.79122059
33regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76716254
34neuronal action potential propagation (GO:0019227)3.65293088
35long-term memory (GO:0007616)3.63635284
36gamma-aminobutyric acid signaling pathway (GO:0007214)3.61967885
37postsynaptic membrane organization (GO:0001941)3.52069955
38positive regulation of synapse maturation (GO:0090129)3.50065484
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.49661762
40proline transport (GO:0015824)3.48497235
41positive regulation of dendritic spine morphogenesis (GO:0061003)3.47706365
42synaptic vesicle endocytosis (GO:0048488)3.43111375
43axonal fasciculation (GO:0007413)3.42156073
44regulation of postsynaptic membrane potential (GO:0060078)3.41304891
45startle response (GO:0001964)3.41296031
46innervation (GO:0060384)3.38926944
47positive regulation of membrane potential (GO:0045838)3.38622385
48regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.37531671
49transmission of nerve impulse (GO:0019226)3.34981621
50regulation of calcium ion-dependent exocytosis (GO:0017158)3.31823846
51neurotransmitter transport (GO:0006836)3.30637395
52gamma-aminobutyric acid transport (GO:0015812)3.30346034
53establishment of integrated proviral latency (GO:0075713)3.29215926
54righting reflex (GO:0060013)3.27709327
55negative regulation of telomere maintenance (GO:0032205)3.27677593
56sequestering of actin monomers (GO:0042989)3.26021573
57regulation of vesicle fusion (GO:0031338)3.24996005
58intraciliary transport (GO:0042073)3.20652017
59G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20297130
60activation of protein kinase A activity (GO:0034199)3.20105051
61response to pheromone (GO:0019236)3.19334710
62regulation of helicase activity (GO:0051095)3.19256309
63dendritic spine organization (GO:0097061)3.18608771
64chaperone-mediated protein transport (GO:0072321)3.17812187
65regulation of dendritic spine morphogenesis (GO:0061001)3.17094533
66response to histamine (GO:0034776)3.16827204
67behavioral defense response (GO:0002209)3.16518989
68behavioral fear response (GO:0001662)3.16518989
69positive regulation of synapse assembly (GO:0051965)3.16506031
70regulation of telomere maintenance (GO:0032204)3.15726310
71negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14444941
72neurotransmitter-gated ion channel clustering (GO:0072578)3.13933172
73cerebellar Purkinje cell differentiation (GO:0021702)3.13619871
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.12684755
75long-term synaptic potentiation (GO:0060291)3.12043304
76establishment of mitochondrion localization (GO:0051654)3.11780589
77regulation of synaptic plasticity (GO:0048167)3.11216236
78membrane hyperpolarization (GO:0060081)3.09044894
79presynaptic membrane assembly (GO:0097105)3.08613668
80nonmotile primary cilium assembly (GO:0035058)3.06581216
81protein complex biogenesis (GO:0070271)3.05172273
82fear response (GO:0042596)3.02819386
83cullin deneddylation (GO:0010388)3.02692472
84regulation of synapse structural plasticity (GO:0051823)3.02115543
85positive regulation of dendritic spine development (GO:0060999)3.01030517
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00449722
87synapse assembly (GO:0007416)3.00315507
88regulation of neurotransmitter levels (GO:0001505)2.99649459
89regulation of neurotransmitter secretion (GO:0046928)2.96082431
90negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96036226
91presynaptic membrane organization (GO:0097090)2.93906444
92mitochondrial respiratory chain complex assembly (GO:0033108)2.93065708
93negative regulation of DNA recombination (GO:0045910)2.92096058
94regulation of telomere maintenance via telomerase (GO:0032210)2.90948794
95regulation of respiratory system process (GO:0044065)2.90711610
96neuromuscular process controlling posture (GO:0050884)2.90659173
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.90235941
98positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90166622
99membrane depolarization (GO:0051899)2.89690900
100cellular potassium ion homeostasis (GO:0030007)2.87846785
101establishment of protein localization to mitochondrial membrane (GO:0090151)2.87713479
102negative regulation of microtubule polymerization (GO:0031115)2.86683913
103positive regulation of neurotransmitter transport (GO:0051590)2.86397574
104mating behavior (GO:0007617)2.86258218
105regulation of neurotransmitter transport (GO:0051588)2.83436667
106positive regulation of neurotransmitter secretion (GO:0001956)2.83203104
107synapse organization (GO:0050808)2.82422692
108synaptic transmission (GO:0007268)2.82256365
109learning (GO:0007612)2.81569431
110negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81282198
111negative regulation of translation, ncRNA-mediated (GO:0040033)2.81282198
112regulation of translation, ncRNA-mediated (GO:0045974)2.81282198
113histone H2A acetylation (GO:0043968)2.81062665
114inner ear receptor cell development (GO:0060119)2.80840141
115neuromuscular process controlling balance (GO:0050885)2.78679200
116chromatin remodeling at centromere (GO:0031055)2.78436438
117social behavior (GO:0035176)2.77878956
118intraspecies interaction between organisms (GO:0051703)2.77878956
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.77506917
120mitochondrial respiratory chain complex I assembly (GO:0032981)2.77506917
121NADH dehydrogenase complex assembly (GO:0010257)2.77506917
122neuronal ion channel clustering (GO:0045161)2.76673471
123regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.76613949
124regulation of development, heterochronic (GO:0040034)2.75764849
125regulation of synaptic transmission (GO:0050804)2.75395382
126regulation of synaptic transmission, GABAergic (GO:0032228)2.75045733
127chemosensory behavior (GO:0007635)2.73852234
128positive regulation of synaptic transmission (GO:0050806)2.73337340
129dendrite development (GO:0016358)2.72895017
130nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71459968
131exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71079486
132olfactory bulb development (GO:0021772)2.71058756
133protein deneddylation (GO:0000338)2.67949668
134CENP-A containing nucleosome assembly (GO:0034080)2.63284418
135retinal ganglion cell axon guidance (GO:0031290)2.63011548
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.62046650
137regulation of mitotic spindle checkpoint (GO:1903504)2.62046650
138negative regulation of DNA-dependent DNA replication (GO:2000104)2.60553225
139somite development (GO:0061053)2.59724560
140mechanosensory behavior (GO:0007638)2.57340423
141DNA ligation (GO:0006266)2.56056712
142telomere maintenance via telomerase (GO:0007004)2.55114262
143establishment of viral latency (GO:0019043)2.53296053
144regulation of gene silencing by RNA (GO:0060966)2.52365168
145regulation of posttranscriptional gene silencing (GO:0060147)2.52365168
146regulation of gene silencing by miRNA (GO:0060964)2.52365168
147single strand break repair (GO:0000012)2.51612022
148epithelial cell differentiation involved in kidney development (GO:0035850)2.50806258
149auditory behavior (GO:0031223)2.50178983
150positive regulation of RNA splicing (GO:0033120)2.49637444
151protein-cofactor linkage (GO:0018065)2.48349378
152histone exchange (GO:0043486)2.46282956
153organelle disassembly (GO:1903008)2.42561130
154regulation of timing of cell differentiation (GO:0048505)2.41149615
155behavioral response to nicotine (GO:0035095)2.41053387
156microtubule depolymerization (GO:0007019)2.39685502
157termination of RNA polymerase III transcription (GO:0006386)2.38211795
158transcription elongation from RNA polymerase III promoter (GO:0006385)2.38211795
159DNA integration (GO:0015074)2.38189964
160regulation of mitochondrial translation (GO:0070129)2.37731535
161mRNA splice site selection (GO:0006376)2.37591761
162negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.34793036
163negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.34793036
164negative regulation of mitotic sister chromatid segregation (GO:0033048)2.34793036
165negative regulation of mitotic sister chromatid separation (GO:2000816)2.34793036
166negative regulation of sister chromatid segregation (GO:0033046)2.34793036
167mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.34637729
168protein neddylation (GO:0045116)2.34484144
169regulation of feeding behavior (GO:0060259)2.33334315
170regulation of meiosis I (GO:0060631)2.33199849
171ribonucleoprotein complex disassembly (GO:0032988)2.32364138
172spermatid nucleus differentiation (GO:0007289)2.32326974
173kinetochore assembly (GO:0051382)2.32129499
174mitochondrion transport along microtubule (GO:0047497)2.30207145
175establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.30207145
176histone H4-K12 acetylation (GO:0043983)2.29702180
177forebrain neuron differentiation (GO:0021879)2.28571571
178negative regulation of transcription regulatory region DNA binding (GO:2000678)2.28064256
179ATP-dependent chromatin remodeling (GO:0043044)2.26764228
180regulation of mRNA splicing, via spliceosome (GO:0048024)2.26554269
181water-soluble vitamin biosynthetic process (GO:0042364)2.25803807
182mitotic spindle checkpoint (GO:0071174)2.25377475
183positive regulation of mitochondrial fission (GO:0090141)2.25108882
184limb bud formation (GO:0060174)2.25080681
185cell fate commitment involved in formation of primary germ layer (GO:0060795)2.24905108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22138717
2GBX2_23144817_ChIP-Seq_PC3_Human3.68115560
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.43898258
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98091911
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89700948
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78464660
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68651399
8REST_21632747_ChIP-Seq_MESCs_Mouse2.63489555
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.59109378
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.56889809
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.55059118
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53936848
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52714926
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52714926
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49450303
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.41083026
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40203002
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.38367630
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37851759
20POU5F1_16153702_ChIP-ChIP_HESCs_Human2.35037658
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32180440
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32013203
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30304172
24MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24819198
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23645511
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21382625
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.19795026
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.18490295
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.16900894
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11934764
31CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11199858
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.09945844
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08880230
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.07666504
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02138595
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97939966
37* SOX2_16153702_ChIP-ChIP_HESCs_Human1.95198645
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94105760
39ZNF274_21170338_ChIP-Seq_K562_Hela1.93789119
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93518221
41AR_21572438_ChIP-Seq_LNCaP_Human1.92113290
42DROSHA_22980978_ChIP-Seq_HELA_Human1.91505624
43ELK1_19687146_ChIP-ChIP_HELA_Human1.90573539
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.89896355
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82669952
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82669608
47TAF15_26573619_Chip-Seq_HEK293_Human1.82644362
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80445572
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77189467
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76781634
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75198774
52SMAD4_21799915_ChIP-Seq_A2780_Human1.71774769
53IGF1R_20145208_ChIP-Seq_DFB_Human1.65913704
54RNF2_27304074_Chip-Seq_NSC_Mouse1.65702064
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.63587583
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.62278755
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61851823
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55850305
59FUS_26573619_Chip-Seq_HEK293_Human1.55017187
60P300_19829295_ChIP-Seq_ESCs_Human1.48504770
61MYC_18940864_ChIP-ChIP_HL60_Human1.46877275
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45963895
63* NANOG_16153702_ChIP-ChIP_HESCs_Human1.44466703
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41342198
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41171791
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39209687
67VDR_22108803_ChIP-Seq_LS180_Human1.38766258
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35855639
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35267869
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33624965
71VDR_23849224_ChIP-Seq_CD4+_Human1.33347205
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32888796
73JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32710099
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31965296
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31832323
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.30915772
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30910404
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30796950
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30723554
80PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30158380
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.29864347
82* STAT3_23295773_ChIP-Seq_U87_Human1.28509288
83IRF1_19129219_ChIP-ChIP_H3396_Human1.27806767
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.27706966
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.27685219
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26911597
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26036230
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25614548
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.24951530
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24917305
91MYC_18555785_ChIP-Seq_MESCs_Mouse1.24169160
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23665817
93AR_25329375_ChIP-Seq_VCAP_Human1.22144318
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21956209
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21574617
96WT1_19549856_ChIP-ChIP_CCG9911_Human1.21552672
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20740563
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19699501
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.19011111
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.18613386
101ERG_21242973_ChIP-ChIP_JURKAT_Human1.18328269
102FOXP3_21729870_ChIP-Seq_TREG_Human1.18283510
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17013284
104TCF4_23295773_ChIP-Seq_U87_Human1.15121204
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14324204
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13987908
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13720166
108AR_19668381_ChIP-Seq_PC3_Human1.13646417
109HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13552116
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10882987
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09274960
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.08969105
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08937532
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08743588
115STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06164867
116SOX9_26525672_Chip-Seq_HEART_Mouse1.05903461
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05814146
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05799385
119RUNX2_22187159_ChIP-Seq_PCA_Human1.05330213
120FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05298504
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05136997
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04442453
123TTF2_22483619_ChIP-Seq_HELA_Human1.03715090
124TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03582073
125POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03081275
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02671915
127SMAD3_21741376_ChIP-Seq_ESCs_Human1.02133128
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98940997
129RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98613996
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98569215
131JUN_21703547_ChIP-Seq_K562_Human0.98408114
132MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98123074
133EWS_26573619_Chip-Seq_HEK293_Human0.96536081
134NANOG_18555785_Chip-Seq_ESCs_Mouse0.96349821
135PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96133087
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95811623
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95811623
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94730576
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94259837
140CBP_20019798_ChIP-Seq_JUKART_Human0.94259837
141PRDM14_20953172_ChIP-Seq_ESCs_Human0.93724817
142TP53_22573176_ChIP-Seq_HFKS_Human0.93650923
143NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93378686
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92281125
145CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91687946
146GABP_19822575_ChIP-Seq_HepG2_Human0.91429609
147SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91105498
148STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90885278
149TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90860894
150TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90701554
151NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90677017
152NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90584581
153YY1_21170310_ChIP-Seq_MESCs_Mouse0.89657391
154ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89380599
155MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88810801
156ER_23166858_ChIP-Seq_MCF-7_Human0.88559114
157WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88534320
158TAL1_26923725_Chip-Seq_HPCs_Mouse0.87678800
159CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87587541
160OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87482345
161ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87450836
162GATA1_26923725_Chip-Seq_HPCs_Mouse0.85535978
163CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85493524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.18557620
2MP0003880_abnormal_central_pattern4.42127261
3MP0003635_abnormal_synaptic_transmissio3.66246159
4MP0004270_analgesia3.22778629
5MP0009745_abnormal_behavioral_response2.98172032
6MP0002063_abnormal_learning/memory/cond2.96312462
7MP0005423_abnormal_somatic_nervous2.74083830
8MP0002064_seizures2.66293152
9MP0009046_muscle_twitch2.61328200
10MP0001968_abnormal_touch/_nociception2.61103598
11MP0002572_abnormal_emotion/affect_behav2.59566566
12MP0002734_abnormal_mechanical_nocicepti2.43498712
13MP0002272_abnormal_nervous_system2.39756960
14MP0001486_abnormal_startle_reflex2.33765605
15MP0003787_abnormal_imprinting2.19024394
16MP0008789_abnormal_olfactory_epithelium2.18666077
17MP0003122_maternal_imprinting2.11857843
18MP0001529_abnormal_vocalization2.09140246
19MP0002735_abnormal_chemical_nociception2.04799204
20MP0002736_abnormal_nociception_after2.04045547
21MP0003136_yellow_coat_color1.99109345
22MP0001501_abnormal_sleep_pattern1.95968818
23MP0002733_abnormal_thermal_nociception1.94366246
24MP0006276_abnormal_autonomic_nervous1.92498177
25MP0002184_abnormal_innervation1.90810341
26MP0002067_abnormal_sensory_capabilities1.86741369
27MP0000778_abnormal_nervous_system1.86007713
28MP0008058_abnormal_DNA_repair1.84478036
29MP0001440_abnormal_grooming_behavior1.81289404
30MP0001970_abnormal_pain_threshold1.80481986
31MP0005646_abnormal_pituitary_gland1.80073359
32MP0005645_abnormal_hypothalamus_physiol1.77580114
33MP0003567_abnormal_fetal_cardiomyocyte1.77528852
34MP0002557_abnormal_social/conspecific_i1.76483742
35MP0001293_anophthalmia1.76441919
36MP0006292_abnormal_olfactory_placode1.62998096
37MP0000049_abnormal_middle_ear1.60721025
38MP0001188_hyperpigmentation1.59451820
39MP0000955_abnormal_spinal_cord1.59256459
40MP0003123_paternal_imprinting1.58673101
41MP0006072_abnormal_retinal_apoptosis1.57541506
42MP0002822_catalepsy1.57320186
43MP0005386_behavior/neurological_phenoty1.53197540
44MP0004924_abnormal_behavior1.53197540
45MP0003121_genomic_imprinting1.52830736
46MP0008877_abnormal_DNA_methylation1.51962646
47MP0003329_amyloid_beta_deposits1.51385585
48MP0002254_reproductive_system_inflammat1.48108437
49MP0003119_abnormal_digestive_system1.47667407
50MP0004811_abnormal_neuron_physiology1.46994488
51MP0001905_abnormal_dopamine_level1.43435632
52MP0001502_abnormal_circadian_rhythm1.42940353
53MP0002882_abnormal_neuron_morphology1.42284206
54MP0002909_abnormal_adrenal_gland1.38399496
55MP0009780_abnormal_chondrocyte_physiolo1.36872530
56MP0000631_abnormal_neuroendocrine_gland1.36523686
57MP0002233_abnormal_nose_morphology1.35919822
58MP0004858_abnormal_nervous_system1.34701995
59MP0001984_abnormal_olfaction1.33400454
60MP0008569_lethality_at_weaning1.33379517
61MP0002653_abnormal_ependyma_morphology1.30398394
62MP0003937_abnormal_limbs/digits/tail_de1.28167589
63MP0002066_abnormal_motor_capabilities/c1.27751492
64MP0003283_abnormal_digestive_organ1.27743152
65MP0004142_abnormal_muscle_tone1.25344580
66MP0002152_abnormal_brain_morphology1.24752694
67MP0002102_abnormal_ear_morphology1.24044061
68MP0002938_white_spotting1.23504804
69MP0003693_abnormal_embryo_hatching1.23194528
70MP0010094_abnormal_chromosome_stability1.21612051
71MP0005551_abnormal_eye_electrophysiolog1.21153905
72MP0008932_abnormal_embryonic_tissue1.19356311
73MP0003879_abnormal_hair_cell1.18799269
74MP0004885_abnormal_endolymph1.18292021
75MP0005084_abnormal_gallbladder_morpholo1.14233234
76MP0001286_abnormal_eye_development1.13856333
77MP0010386_abnormal_urinary_bladder1.11506918
78MP0004145_abnormal_muscle_electrophysio1.10656873
79MP0000013_abnormal_adipose_tissue1.09599371
80MP0000516_abnormal_urinary_system1.06126788
81MP0005367_renal/urinary_system_phenotyp1.06126788
82MP0003718_maternal_effect0.97934560
83MP0004742_abnormal_vestibular_system0.96670316
84MP0002752_abnormal_somatic_nervous0.96442329
85MP0002229_neurodegeneration0.95774331
86MP0003755_abnormal_palate_morphology0.94456690
87MP0003861_abnormal_nervous_system0.93034612
88MP0003315_abnormal_perineum_morphology0.92942141
89MP0006035_abnormal_mitochondrial_morpho0.91654076
90MP0005391_vision/eye_phenotype0.91065597
91MP0002069_abnormal_eating/drinking_beha0.89974250
92MP0005248_abnormal_Harderian_gland0.89230875
93MP0000566_synostosis0.88620043
94MP0004957_abnormal_blastocyst_morpholog0.88351516
95MP0003077_abnormal_cell_cycle0.87608788
96MP0001963_abnormal_hearing_physiology0.87287808
97MP0004233_abnormal_muscle_weight0.86992391
98MP0003632_abnormal_nervous_system0.86281130
99MP0003631_nervous_system_phenotype0.85897749
100MP0005379_endocrine/exocrine_gland_phen0.85810894
101MP0009672_abnormal_birth_weight0.84927302
102MP0009703_decreased_birth_body0.83449687
103MP0005394_taste/olfaction_phenotype0.82463718
104MP0005499_abnormal_olfactory_system0.82463718
105MP0000537_abnormal_urethra_morphology0.81934315
106MP0002638_abnormal_pupillary_reflex0.81713177
107MP0001485_abnormal_pinna_reflex0.81635808
108MP0010030_abnormal_orbit_morphology0.81633261
109MP0008057_abnormal_DNA_replication0.81576970
110MP0003633_abnormal_nervous_system0.81545047
111MP0003385_abnormal_body_wall0.80977197
112MP0002697_abnormal_eye_size0.80541812
113MP0002234_abnormal_pharynx_morphology0.79971383
114MP0005195_abnormal_posterior_eye0.79271021
115MP0003111_abnormal_nucleus_morphology0.78770701
116MP0003941_abnormal_skin_development0.78758692
117MP0001299_abnormal_eye_distance/0.78377200
118MP0005253_abnormal_eye_physiology0.74948366
119MP0004085_abnormal_heartbeat0.73386191
120MP0002837_dystrophic_cardiac_calcinosis0.72876738
121MP0005187_abnormal_penis_morphology0.72282926
122MP0008872_abnormal_physiological_respon0.71769234
123MP0003634_abnormal_glial_cell0.70820422
124MP0002751_abnormal_autonomic_nervous0.69679484
125MP0003938_abnormal_ear_development0.67822798
126MP0004133_heterotaxia0.67498103
127MP0002090_abnormal_vision0.67300641
128MP0000751_myopathy0.66340934
129MP0001664_abnormal_digestion0.65212715
130MP0001177_atelectasis0.64571454
131MP0003698_abnormal_male_reproductive0.64308497
132MP0000026_abnormal_inner_ear0.64050720
133MP0005623_abnormal_meninges_morphology0.63887445
134MP0000569_abnormal_digit_pigmentation0.61487671
135MP0003890_abnormal_embryonic-extraembry0.61409093
136MP0001943_abnormal_respiration0.60310746
137MP0000534_abnormal_ureter_morphology0.56415136

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.10404932
2Myokymia (HP:0002411)5.11724683
3Focal seizures (HP:0007359)4.77474682
4Visual hallucinations (HP:0002367)4.69040919
5Epileptic encephalopathy (HP:0200134)3.95397958
6Atonic seizures (HP:0010819)3.88666354
7Progressive cerebellar ataxia (HP:0002073)3.72961602
8Colon cancer (HP:0003003)3.71706974
9Febrile seizures (HP:0002373)3.71246117
10Septo-optic dysplasia (HP:0100842)3.62015888
11Absence seizures (HP:0002121)3.40506034
12Generalized tonic-clonic seizures (HP:0002069)3.25366139
13Cortical dysplasia (HP:0002539)3.20428759
14Dialeptic seizures (HP:0011146)3.20427631
15Broad-based gait (HP:0002136)3.06816330
16Agitation (HP:0000713)2.98562815
17Ankle clonus (HP:0011448)2.95648434
18Supranuclear gaze palsy (HP:0000605)2.94749117
19Hyperglycinemia (HP:0002154)2.83920815
20Excessive salivation (HP:0003781)2.80275944
21Drooling (HP:0002307)2.80275944
22Impaired vibration sensation in the lower limbs (HP:0002166)2.77009668
23Action tremor (HP:0002345)2.70397764
24Hepatoblastoma (HP:0002884)2.64383480
25Truncal ataxia (HP:0002078)2.62170293
26Hemiparesis (HP:0001269)2.62155609
27Pancreatic fibrosis (HP:0100732)2.61124889
28Limb dystonia (HP:0002451)2.59588315
29Urinary bladder sphincter dysfunction (HP:0002839)2.59213847
30Gaze-evoked nystagmus (HP:0000640)2.58528427
31Acute necrotizing encephalopathy (HP:0006965)2.57418606
32Hyperventilation (HP:0002883)2.55632253
33Optic nerve hypoplasia (HP:0000609)2.54535271
34Epileptiform EEG discharges (HP:0011182)2.45609110
35Impaired smooth pursuit (HP:0007772)2.45458445
36Poor eye contact (HP:0000817)2.44914458
37Anxiety (HP:0000739)2.42944679
38Papilledema (HP:0001085)2.42653368
39Depression (HP:0000716)2.41466642
40True hermaphroditism (HP:0010459)2.40599151
41Amblyopia (HP:0000646)2.39409569
42Gait imbalance (HP:0002141)2.39261420
43Abnormal mitochondria in muscle tissue (HP:0008316)2.39112645
44EEG with generalized epileptiform discharges (HP:0011198)2.38909436
45Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.36010137
46Dysmetria (HP:0001310)2.35416674
47Abnormality of midbrain morphology (HP:0002418)2.34713396
48Molar tooth sign on MRI (HP:0002419)2.34713396
49Lissencephaly (HP:0001339)2.33046664
50Broad foot (HP:0001769)2.32765671
51Acute encephalopathy (HP:0006846)2.32351326
52Mutism (HP:0002300)2.31248376
53Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30878359
54Methylmalonic acidemia (HP:0002912)2.29602111
55Pancreatic cysts (HP:0001737)2.29484934
56Protruding tongue (HP:0010808)2.28996870
57Supernumerary spleens (HP:0009799)2.28545157
58Hypsarrhythmia (HP:0002521)2.28446906
59Cerebral inclusion bodies (HP:0100314)2.28193110
60Impaired social interactions (HP:0000735)2.27505002
61Abnormal social behavior (HP:0012433)2.27505002
62Spastic gait (HP:0002064)2.27296314
63Abnormal eating behavior (HP:0100738)2.25797524
64Absent septum pellucidum (HP:0001331)2.25055667
65Genetic anticipation (HP:0003743)2.24589614
66Intestinal atresia (HP:0011100)2.23775426
67Mitochondrial inheritance (HP:0001427)2.21344390
68Hepatocellular necrosis (HP:0001404)2.21074894
69Progressive macrocephaly (HP:0004481)2.20894436
70Abnormality of the corticospinal tract (HP:0002492)2.20175663
71Dysdiadochokinesis (HP:0002075)2.18541046
72Abnormality of the labia minora (HP:0012880)2.17988558
73Lipid accumulation in hepatocytes (HP:0006561)2.14679981
74Absent speech (HP:0001344)2.14679946
75Diplopia (HP:0000651)2.13644096
76Abnormality of binocular vision (HP:0011514)2.13644096
77Increased hepatocellular lipid droplets (HP:0006565)2.11726305
78Polyphagia (HP:0002591)2.11401308
79Nephronophthisis (HP:0000090)2.11288456
80Increased CSF lactate (HP:0002490)2.10632131
81Ankyloglossia (HP:0010296)2.09501751
82Specific learning disability (HP:0001328)2.07914725
83Abnormality of ocular smooth pursuit (HP:0000617)2.07821622
84Anencephaly (HP:0002323)2.06238977
85Abnormality of the septum pellucidum (HP:0007375)2.05624324
86Abnormality of the metopic suture (HP:0005556)2.05230750
87Medulloblastoma (HP:0002885)2.02219214
88Amyotrophic lateral sclerosis (HP:0007354)2.02024246
89Medial flaring of the eyebrow (HP:0010747)2.00957940
90Congenital primary aphakia (HP:0007707)2.00672978
91Postaxial hand polydactyly (HP:0001162)1.99988056
92Pachygyria (HP:0001302)1.99704374
93Neurofibrillary tangles (HP:0002185)1.99269942
94Atrophy/Degeneration involving motor neurons (HP:0007373)1.98765018
95Progressive inability to walk (HP:0002505)1.96221859
96Micropenis (HP:0000054)1.96003461
97Urinary urgency (HP:0000012)1.95642374
98Failure to thrive in infancy (HP:0001531)1.94410901
99Poor suck (HP:0002033)1.93665645
100Decreased testicular size (HP:0008734)1.93288298
101Shoulder girdle muscle weakness (HP:0003547)1.92552266
102Abnormal lung lobation (HP:0002101)1.92386878
103Preaxial hand polydactyly (HP:0001177)1.92042625
104Abnormality of the hip-girdle musculature (HP:0001445)1.91762772
105Abnormality of the musculature of the pelvis (HP:0001469)1.91762772
106Poor coordination (HP:0002370)1.91537319
107Stereotypic behavior (HP:0000733)1.91347953
108Fetal akinesia sequence (HP:0001989)1.91078537
109Aqueductal stenosis (HP:0002410)1.90996252
110Abnormal hair whorl (HP:0010721)1.90186635
111Narrow forehead (HP:0000341)1.87590149
112Anosmia (HP:0000458)1.87528133
113Hepatic necrosis (HP:0002605)1.87392952
114Esotropia (HP:0000565)1.86048362
115Abnormality of glycine metabolism (HP:0010895)1.85557100
116Abnormality of serine family amino acid metabolism (HP:0010894)1.85557100
117Anophthalmia (HP:0000528)1.85158844
118Scrotal hypoplasia (HP:0000046)1.84617246
119Hypoventilation (HP:0002791)1.83487169
120Spastic diplegia (HP:0001264)1.83259286
121Growth hormone deficiency (HP:0000824)1.82825635
122Shawl scrotum (HP:0000049)1.82777764
123Stenosis of the external auditory canal (HP:0000402)1.80962004
124Abnormal ciliary motility (HP:0012262)1.80776939
125Nephrogenic diabetes insipidus (HP:0009806)1.80082230
126Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79852671
127Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79852671
128Insidious onset (HP:0003587)1.79825109
129Termporal pattern (HP:0011008)1.79825109
130Torticollis (HP:0000473)1.79726016
131Neoplasm of the adrenal cortex (HP:0100641)1.79670298
132Pendular nystagmus (HP:0012043)1.79442148
133Gastrointestinal atresia (HP:0002589)1.79072530
134Prominent metopic ridge (HP:0005487)1.78355651
135Oligodactyly (hands) (HP:0001180)1.77623002
136Genital tract atresia (HP:0001827)1.77549370
137Delusions (HP:0000746)1.77509571
138Bradykinesia (HP:0002067)1.77353162
139Abolished electroretinogram (ERG) (HP:0000550)1.77280152
140Restlessness (HP:0000711)1.77152521
141Sclerocornea (HP:0000647)1.76680923
142Abnormality of the lower motor neuron (HP:0002366)1.76528853
143Split foot (HP:0001839)1.76355992
144Esophageal atresia (HP:0002032)1.76128762
145Inability to walk (HP:0002540)1.75563871
146Hyperglycinuria (HP:0003108)1.75405840
147Occipital encephalocele (HP:0002085)1.75391213
148Cerebral edema (HP:0002181)1.74483583
149Focal dystonia (HP:0004373)1.74027730
150Abnormality of abdominal situs (HP:0011620)1.73283126
151Abdominal situs inversus (HP:0003363)1.73283126
152Labial hypoplasia (HP:0000066)1.73180846
153Rib fusion (HP:0000902)1.72987466
154Degeneration of the lateral corticospinal tracts (HP:0002314)1.72725798
155Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72725798
156Abnormal respiratory motile cilium physiology (HP:0012261)1.71640900
157Lower limb muscle weakness (HP:0007340)1.71585934
158Meckel diverticulum (HP:0002245)1.71432874
159Clonus (HP:0002169)1.71150311
160Abnormality of salivation (HP:0100755)1.70954670
161Vaginal atresia (HP:0000148)1.70180974
162Decreased muscle mass (HP:0003199)1.70103344
163Hemivertebrae (HP:0002937)1.69914618
164Psychosis (HP:0000709)1.69833199
165Dandy-Walker malformation (HP:0001305)1.67927798
166Postural instability (HP:0002172)1.67270004
167Hyperthyroidism (HP:0000836)1.67221465
168Gastroesophageal reflux (HP:0002020)1.65636901
169Retinal dysplasia (HP:0007973)1.65275982
170Hemiplegia (HP:0002301)1.64167315
171Gait ataxia (HP:0002066)1.63810216
172Hypogonadotrophic hypogonadism (HP:0000044)1.62472103
173Morphological abnormality of the pyramidal tract (HP:0002062)1.62460075
174Intention tremor (HP:0002080)1.61802407
175Scanning speech (HP:0002168)1.61071525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.74107353
2MAP3K93.68598835
3MAP3K43.38193747
4EPHA43.25389909
5TRIM282.99619815
6MARK12.84938272
7MAP2K72.74454315
8SRPK12.63465791
9MKNK22.40949307
10MINK12.35596940
11MKNK12.10817041
12PNCK2.10198897
13CASK2.09770879
14NTRK22.06234018
15MAP4K22.05804787
16MAP3K121.97171030
17KSR21.97090304
18BCKDK1.96571857
19BUB11.91189896
20MAP2K41.90949666
21TSSK61.90424753
22PAK61.88588125
23NUAK11.84492234
24CDC71.84019348
25DYRK31.79403323
26KSR11.79162921
27AKT31.77318415
28NEK11.74580006
29VRK21.72025586
30WNK31.68527263
31MAPK131.67465940
32ARAF1.66830178
33MAP3K131.61485836
34UHMK11.54866888
35PLK21.54748366
36TNIK1.54457113
37MAP3K61.53922759
38TAF11.45197312
39PRKD31.43464770
40WEE11.39816194
41LATS21.36892486
42VRK11.32898570
43BMPR21.32743491
44NTRK11.30706583
45GRK51.28168257
46DAPK21.24646589
47CDK51.23592588
48PLK41.21063471
49RIPK41.14278459
50DAPK11.13642274
51PINK11.12821290
52ERBB31.11579715
53CDK191.11510842
54TYRO31.08388582
55TTK1.05440849
56ZAK1.05253901
57PLK11.04023448
58RAF11.03942713
59BRAF1.02074807
60CSNK1G21.00304452
61MAP3K21.00223871
62SIK20.99938956
63CAMK2A0.99309285
64MOS0.97885104
65STK160.96708749
66PRKCG0.96509102
67FES0.96329354
68DYRK1A0.94495925
69STK380.92895127
70EPHB20.91939344
71EPHA30.91672989
72PHKG20.87019188
73PHKG10.87019188
74TAOK30.87010517
75PAK30.86066206
76BMPR1B0.85424466
77CDK180.85063304
78CDK150.83430739
79CDK140.82909234
80FGFR20.81777115
81PASK0.76721354
82LIMK10.75870636
83CAMKK10.75333484
84SGK2230.74966242
85SGK4940.74966242
86RET0.74762069
87CAMK2B0.74030958
88CDK11A0.73064120
89EIF2AK30.71600125
90FRK0.71124690
91RPS6KA40.67763227
92FER0.67296776
93PKN10.67238329
94PBK0.66975355
95BRSK20.66357107
96OXSR10.65582532
97BCR0.64217348
98ATR0.64097846
99ADRBK20.63180458
100CAMKK20.62602101
101CSNK1G30.62450387
102NME10.60817433
103CAMK10.59830433
104FGR0.59347460
105CCNB10.59080121
106PTK2B0.58264864
107DYRK20.56629752
108WNK10.56137047
109STK38L0.56110864
110SIK30.55833201
111SGK10.54687921
112MARK20.54637217
113MAPK150.53493956
114SGK20.53235789
115STK110.52279530
116AURKA0.52113029
117ATM0.51119414
118CAMK2D0.50825445
119GRK10.50058277
120SCYL20.48059121
121NEK20.46360462
122PRKCE0.46316093
123CDC42BPA0.46158531
124NEK60.46133346
125CSNK1A1L0.45841893
126CSNK1A10.44841456
127PRKDC0.44320697
128TAOK10.43974176
129EIF2AK20.43733198
130MAPK100.42762466
131ADRBK10.42728015
132CHEK20.42690593
133CSNK1E0.41523362
134DYRK1B0.40012684
135BRD40.38795072
136RPS6KA30.38592961
137PRKACB0.38523701
138CAMK2G0.38433017
139CAMK1G0.38398535
140FLT30.38094900
141PRPF4B0.37759282
142HIPK20.37148930
143BRSK10.36550614
144CSNK1G10.36189709
145RPS6KA50.35322955
146CSNK2A10.35083346
147PLK30.34753392
148MAPK90.34553969
149MAP3K100.32835697
150CSNK2A20.32497759
151PRKCZ0.32403281
152CDK30.32383658
153MAPKAPK50.32330301
154MAP3K10.31601225
155ERBB40.31407996
156CDK20.31267860
157CSNK1D0.30916568

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.08931600
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04111688
3Protein export_Homo sapiens_hsa030602.97913984
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95281086
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.78440992
6GABAergic synapse_Homo sapiens_hsa047272.75408809
7Circadian entrainment_Homo sapiens_hsa047132.61541222
8Long-term potentiation_Homo sapiens_hsa047202.60919983
9Glutamatergic synapse_Homo sapiens_hsa047242.57058762
10RNA polymerase_Homo sapiens_hsa030202.51125068
11Morphine addiction_Homo sapiens_hsa050322.47047260
12Amphetamine addiction_Homo sapiens_hsa050312.44973252
13Olfactory transduction_Homo sapiens_hsa047402.35994005
14Dopaminergic synapse_Homo sapiens_hsa047282.27275225
15Proteasome_Homo sapiens_hsa030502.13757843
16Taste transduction_Homo sapiens_hsa047422.08683365
17Insulin secretion_Homo sapiens_hsa049112.08656763
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07449179
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.05870107
20Spliceosome_Homo sapiens_hsa030401.98400487
21Salivary secretion_Homo sapiens_hsa049701.97340192
22Propanoate metabolism_Homo sapiens_hsa006401.96986931
23Serotonergic synapse_Homo sapiens_hsa047261.96450770
24Basal transcription factors_Homo sapiens_hsa030221.91960322
25Long-term depression_Homo sapiens_hsa047301.91216936
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90760295
27Steroid biosynthesis_Homo sapiens_hsa001001.89766381
28Non-homologous end-joining_Homo sapiens_hsa034501.84851161
29Butanoate metabolism_Homo sapiens_hsa006501.82742489
30Cocaine addiction_Homo sapiens_hsa050301.82605261
31Cholinergic synapse_Homo sapiens_hsa047251.79475845
32Mismatch repair_Homo sapiens_hsa034301.76755161
33Gastric acid secretion_Homo sapiens_hsa049711.75071694
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69773718
35Renin secretion_Homo sapiens_hsa049241.65784135
36Fanconi anemia pathway_Homo sapiens_hsa034601.64732292
37RNA degradation_Homo sapiens_hsa030181.64184944
38Fatty acid elongation_Homo sapiens_hsa000621.63533397
39Oxytocin signaling pathway_Homo sapiens_hsa049211.61026373
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59244118
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58456884
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57392324
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57183142
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56978985
45GnRH signaling pathway_Homo sapiens_hsa049121.56914735
46Collecting duct acid secretion_Homo sapiens_hsa049661.56509533
47Calcium signaling pathway_Homo sapiens_hsa040201.56298251
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55685579
49Base excision repair_Homo sapiens_hsa034101.55467878
50RNA transport_Homo sapiens_hsa030131.54215346
51Oocyte meiosis_Homo sapiens_hsa041141.52853761
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50922284
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47306419
54Selenocompound metabolism_Homo sapiens_hsa004501.47175065
55Homologous recombination_Homo sapiens_hsa034401.44104996
56Gap junction_Homo sapiens_hsa045401.39652930
57Phototransduction_Homo sapiens_hsa047441.36566594
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34668167
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31722736
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25520246
61cAMP signaling pathway_Homo sapiens_hsa040241.23280241
62Cysteine and methionine metabolism_Homo sapiens_hsa002701.21925367
63Vibrio cholerae infection_Homo sapiens_hsa051101.20402941
64Estrogen signaling pathway_Homo sapiens_hsa049151.20364877
65Axon guidance_Homo sapiens_hsa043601.19841448
66Cell cycle_Homo sapiens_hsa041101.12363703
67Melanogenesis_Homo sapiens_hsa049161.12283013
68Basal cell carcinoma_Homo sapiens_hsa052171.09779828
69DNA replication_Homo sapiens_hsa030301.08731586
70Cardiac muscle contraction_Homo sapiens_hsa042601.06883613
71Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05372153
72Type II diabetes mellitus_Homo sapiens_hsa049301.04704303
73Nucleotide excision repair_Homo sapiens_hsa034201.03548469
74ErbB signaling pathway_Homo sapiens_hsa040121.03409279
75Vitamin B6 metabolism_Homo sapiens_hsa007501.00842563
76Ribosome_Homo sapiens_hsa030100.99109698
77Dorso-ventral axis formation_Homo sapiens_hsa043200.98490882
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.97955210
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.97874364
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93977414
81Peroxisome_Homo sapiens_hsa041460.93182413
82Glioma_Homo sapiens_hsa052140.92048639
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91667810
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91497049
85Pyrimidine metabolism_Homo sapiens_hsa002400.91209950
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90838734
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87877922
88Folate biosynthesis_Homo sapiens_hsa007900.87834143
89Purine metabolism_Homo sapiens_hsa002300.84954890
90Pyruvate metabolism_Homo sapiens_hsa006200.84790117
91Ovarian steroidogenesis_Homo sapiens_hsa049130.84350626
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81195915
93Thyroid hormone synthesis_Homo sapiens_hsa049180.80945769
94Pancreatic secretion_Homo sapiens_hsa049720.80926071
95Circadian rhythm_Homo sapiens_hsa047100.77994246
96beta-Alanine metabolism_Homo sapiens_hsa004100.75817835
97Choline metabolism in cancer_Homo sapiens_hsa052310.75424964
98Biosynthesis of amino acids_Homo sapiens_hsa012300.74636258
99MAPK signaling pathway_Homo sapiens_hsa040100.72409982
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.72135965
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70006827
102Wnt signaling pathway_Homo sapiens_hsa043100.69982872
103Carbon metabolism_Homo sapiens_hsa012000.69792472
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69301207
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69301047
106Ether lipid metabolism_Homo sapiens_hsa005650.68335206
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67961568
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66643162
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65955748
110Hedgehog signaling pathway_Homo sapiens_hsa043400.65321244
111Alzheimers disease_Homo sapiens_hsa050100.64518295
112Alcoholism_Homo sapiens_hsa050340.63454399
113Dilated cardiomyopathy_Homo sapiens_hsa054140.62622925
114Ras signaling pathway_Homo sapiens_hsa040140.61036528
115Fatty acid metabolism_Homo sapiens_hsa012120.61016266
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60537518
117Metabolic pathways_Homo sapiens_hsa011000.60423289
118Oxidative phosphorylation_Homo sapiens_hsa001900.60307418
119Type I diabetes mellitus_Homo sapiens_hsa049400.59343505
120Glucagon signaling pathway_Homo sapiens_hsa049220.58898378
121Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58776530
122Inositol phosphate metabolism_Homo sapiens_hsa005620.57111103
123Regulation of autophagy_Homo sapiens_hsa041400.55669134
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55146356
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55018428
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52523072
127Renal cell carcinoma_Homo sapiens_hsa052110.52125213
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52042775
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51834704
130p53 signaling pathway_Homo sapiens_hsa041150.49278261
131Huntingtons disease_Homo sapiens_hsa050160.48835985
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.46951095
133Maturity onset diabetes of the young_Homo sapiens_hsa049500.46260178
134mTOR signaling pathway_Homo sapiens_hsa041500.45334896
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45329113
136Rap1 signaling pathway_Homo sapiens_hsa040150.45136745
137VEGF signaling pathway_Homo sapiens_hsa043700.45036206
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43365103
139* mRNA surveillance pathway_Homo sapiens_hsa030150.43334832
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.42362130
141Parkinsons disease_Homo sapiens_hsa050120.42241736
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41851621
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.41615031
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40587233
145Colorectal cancer_Homo sapiens_hsa052100.39944179
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39406242
147Retinol metabolism_Homo sapiens_hsa008300.38824785
148TGF-beta signaling pathway_Homo sapiens_hsa043500.34211259
149Hippo signaling pathway_Homo sapiens_hsa043900.33260832
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32426674
151Prion diseases_Homo sapiens_hsa050200.32172665
152Insulin signaling pathway_Homo sapiens_hsa049100.31897560
153Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31549620
154Fatty acid degradation_Homo sapiens_hsa000710.30513807
155Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30262072
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29868615
157Arginine and proline metabolism_Homo sapiens_hsa003300.29320287
158Tight junction_Homo sapiens_hsa045300.29089205
159Endocytosis_Homo sapiens_hsa041440.27833190
160Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27802869
161Melanoma_Homo sapiens_hsa052180.25572011
162SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24864866

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