GSS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.55320763
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.55320763
3L-phenylalanine metabolic process (GO:0006558)6.52784372
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.52784372
5cysteine metabolic process (GO:0006534)6.13030854
6glyoxylate metabolic process (GO:0046487)5.94221723
7aromatic amino acid family catabolic process (GO:0009074)5.89487291
8COPI coating of Golgi vesicle (GO:0048205)5.45617736
9Golgi transport vesicle coating (GO:0048200)5.45617736
10lysine catabolic process (GO:0006554)5.45280628
11lysine metabolic process (GO:0006553)5.45280628
12drug transmembrane transport (GO:0006855)5.39398960
13indole-containing compound catabolic process (GO:0042436)5.31324092
14indolalkylamine catabolic process (GO:0046218)5.31324092
15tryptophan catabolic process (GO:0006569)5.31324092
16urate metabolic process (GO:0046415)5.10934525
17sulfur amino acid catabolic process (GO:0000098)5.03710212
18protein maturation by protein folding (GO:0022417)5.02478898
19tryptophan metabolic process (GO:0006568)4.97791350
20kynurenine metabolic process (GO:0070189)4.79977168
21drug transport (GO:0015893)4.72103236
22serine family amino acid catabolic process (GO:0009071)4.65354951
23aldehyde catabolic process (GO:0046185)4.60339577
24serine family amino acid metabolic process (GO:0009069)4.58790694
25serine family amino acid biosynthetic process (GO:0009070)4.57848022
26bile acid biosynthetic process (GO:0006699)4.53099678
27amino-acid betaine metabolic process (GO:0006577)4.52356000
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.51464678
29homocysteine metabolic process (GO:0050667)4.50227383
30aromatic amino acid family metabolic process (GO:0009072)4.42204059
31aspartate family amino acid catabolic process (GO:0009068)4.30712084
32heme transport (GO:0015886)4.28037339
33drug catabolic process (GO:0042737)4.27123177
34short-chain fatty acid metabolic process (GO:0046459)4.26145968
35cellular modified amino acid catabolic process (GO:0042219)4.19718765
36alpha-amino acid catabolic process (GO:1901606)4.13537380
37acetyl-CoA metabolic process (GO:0006084)4.06886313
38regulation of triglyceride catabolic process (GO:0010896)4.03436135
39cellular amino acid catabolic process (GO:0009063)4.03165989
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.00509195
41protein retention in ER lumen (GO:0006621)4.00242583
42urea cycle (GO:0000050)3.98090783
43urea metabolic process (GO:0019627)3.98090783
44glutamate metabolic process (GO:0006536)3.97184936
45bile acid metabolic process (GO:0008206)3.96933418
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.96775800
47cellular ketone body metabolic process (GO:0046950)3.95317186
48nucleobase-containing small molecule interconversion (GO:0015949)3.95205095
49proline biosynthetic process (GO:0006561)3.93386794
50response to mercury ion (GO:0046689)3.90545602
51nitrogen cycle metabolic process (GO:0071941)3.86685902
52exogenous drug catabolic process (GO:0042738)3.84367325
53ethanol oxidation (GO:0006069)3.80213675
54amine catabolic process (GO:0009310)3.78455159
55cellular biogenic amine catabolic process (GO:0042402)3.78455159
56mitotic nuclear envelope reassembly (GO:0007084)3.77946112
57nuclear envelope reassembly (GO:0031468)3.77946112
58coenzyme catabolic process (GO:0009109)3.75040363
59branched-chain amino acid catabolic process (GO:0009083)3.74491821
60fatty acid beta-oxidation (GO:0006635)3.74005968
61alpha-linolenic acid metabolic process (GO:0036109)3.72428598
62glycine metabolic process (GO:0006544)3.71964408
63indolalkylamine metabolic process (GO:0006586)3.70922684
64regulation of translational fidelity (GO:0006450)3.70642654
65fructose metabolic process (GO:0006000)3.69556518
66branched-chain amino acid metabolic process (GO:0009081)3.69460197
67establishment of integrated proviral latency (GO:0075713)3.68356518
68cellular glucuronidation (GO:0052695)3.67217419
69cofactor catabolic process (GO:0051187)3.66514511
70carnitine metabolic process (GO:0009437)3.65708676
71organic acid catabolic process (GO:0016054)3.64079674
72carboxylic acid catabolic process (GO:0046395)3.64079674
73proline metabolic process (GO:0006560)3.62764797
74regulation of mitochondrial translation (GO:0070129)3.62142187
75uronic acid metabolic process (GO:0006063)3.61028237
76glucuronate metabolic process (GO:0019585)3.61028237
77fatty acid oxidation (GO:0019395)3.59537491
78tyrosine metabolic process (GO:0006570)3.59318706
79negative regulation of fibrinolysis (GO:0051918)3.59189481
80* glutathione derivative metabolic process (GO:1901685)3.58967113
81* glutathione derivative biosynthetic process (GO:1901687)3.58967113
82deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.58368836
83L-ascorbic acid metabolic process (GO:0019852)3.55185887
84lipid oxidation (GO:0034440)3.54964520
85DNA strand elongation involved in DNA replication (GO:0006271)3.54697988
86peptidyl-glutamic acid carboxylation (GO:0017187)3.49015166
87protein carboxylation (GO:0018214)3.49015166
88high-density lipoprotein particle remodeling (GO:0034375)3.48748714
89organic cation transport (GO:0015695)3.48452612
90DNA unwinding involved in DNA replication (GO:0006268)3.47100406
91* nonribosomal peptide biosynthetic process (GO:0019184)3.46186199
92DNA strand elongation (GO:0022616)3.44829808
93response to nitrosative stress (GO:0051409)3.44583659
94aminoglycoside antibiotic metabolic process (GO:0030647)3.44153585
95valine metabolic process (GO:0006573)3.42716803
96fatty acid catabolic process (GO:0009062)3.42621441
97formation of translation preinitiation complex (GO:0001731)3.42012286
98plasma lipoprotein particle clearance (GO:0034381)3.41962790
99flavonoid metabolic process (GO:0009812)3.41130569
100benzene-containing compound metabolic process (GO:0042537)3.41052293
101L-serine metabolic process (GO:0006563)3.40411045
102ketone body metabolic process (GO:1902224)3.39737272
103regulation of cholesterol esterification (GO:0010872)3.38146595
104drug metabolic process (GO:0017144)3.38041174
105telomere maintenance via semi-conservative replication (GO:0032201)3.36959506
106bile acid and bile salt transport (GO:0015721)3.36011365
107phosphate ion transmembrane transport (GO:0035435)3.35582027
108phosphate ion transport (GO:0006817)3.34665313
109negative regulation of sterol transport (GO:0032372)3.34279106
110negative regulation of cholesterol transport (GO:0032375)3.34279106
111monocarboxylic acid catabolic process (GO:0072329)3.33481663
112sulfur amino acid metabolic process (GO:0000096)3.32995912
113pentose-phosphate shunt (GO:0006098)3.32991775
114acylglycerol homeostasis (GO:0055090)3.32775783
115triglyceride homeostasis (GO:0070328)3.32775783
116* glutathione metabolic process (GO:0006749)3.31879973
117regulation of cellular amino acid metabolic process (GO:0006521)3.30633124
118* glutathione biosynthetic process (GO:0006750)3.29833615
119response to phenylpropanoid (GO:0080184)3.28930880
1202-oxoglutarate metabolic process (GO:0006103)3.28499815
121negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28455647
122mitotic chromosome condensation (GO:0007076)3.27306562
123tRNA aminoacylation for protein translation (GO:0006418)3.27083773
124retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.26704236
125establishment of viral latency (GO:0019043)3.25012917
126GDP-mannose metabolic process (GO:0019673)3.24149628
127NADPH regeneration (GO:0006740)3.23703391
128negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.19308666
129positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17309158
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16012709
131negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14407832
132negative regulation of ligase activity (GO:0051352)3.14407832
133amino acid activation (GO:0043038)3.13337244
134tRNA aminoacylation (GO:0043039)3.13337244
135regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.11212418
136pteridine-containing compound biosynthetic process (GO:0042559)3.03751394
137pentose metabolic process (GO:0019321)2.94950267
138tricarboxylic acid cycle (GO:0006099)2.94097358
139glucose catabolic process (GO:0006007)2.93481812
140proteasome assembly (GO:0043248)2.92483499
141DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92274207
142positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.91494297
143intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91073498
144signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91073498
145signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87789762
146signal transduction involved in DNA damage checkpoint (GO:0072422)2.87789762
147signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86571799
148signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86571799
149signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86571799
150ribosomal small subunit assembly (GO:0000028)2.80917809
151positive regulation of ligase activity (GO:0051351)2.80301718
152ribosome assembly (GO:0042255)2.79094287
153signal transduction involved in cell cycle checkpoint (GO:0072395)2.78698702
154NADH metabolic process (GO:0006734)2.75575194
155ribosome biogenesis (GO:0042254)2.75082812
156negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.73748608
157mitotic sister chromatid segregation (GO:0000070)2.71174093
158folic acid-containing compound biosynthetic process (GO:0009396)2.68559518
159regulation of ubiquitin-protein transferase activity (GO:0051438)2.67390234
160mitotic nuclear envelope disassembly (GO:0007077)2.66830015
161nucleotide-sugar biosynthetic process (GO:0009226)2.65510824
162telomere maintenance via recombination (GO:0000722)2.60467976
163viral mRNA export from host cell nucleus (GO:0046784)2.59035890
164regulation of ligase activity (GO:0051340)2.58997669
165ribonucleoprotein complex biogenesis (GO:0022613)2.58872315
166monosaccharide biosynthetic process (GO:0046364)2.58152775
167glycosphingolipid catabolic process (GO:0046479)2.57832031
168regulation of mitotic spindle organization (GO:0060236)2.56974024
169oxidative phosphorylation (GO:0006119)2.56527039
170glucose 6-phosphate metabolic process (GO:0051156)2.55053029
171deoxyribonucleotide biosynthetic process (GO:0009263)2.54493103
172glycolytic process (GO:0006096)2.53490060
173mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.53216501
174gluconeogenesis (GO:0006094)2.52221554
175ribosomal small subunit biogenesis (GO:0042274)2.52070206
176ribosomal large subunit biogenesis (GO:0042273)2.50114442
177mitotic recombination (GO:0006312)2.49490393
178purine nucleobase biosynthetic process (GO:0009113)2.49429650
179DNA replication initiation (GO:0006270)2.48224150
180heme biosynthetic process (GO:0006783)2.48116476
181regulation of cellular amine metabolic process (GO:0033238)2.47381661
1824-hydroxyproline metabolic process (GO:0019471)2.46796987
183de novo protein folding (GO:0006458)2.41801412
184pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.41747580
185hexose biosynthetic process (GO:0019319)2.41412972
186vesicle coating (GO:0006901)2.41079694
187membrane disassembly (GO:0030397)2.39066946
188nuclear envelope disassembly (GO:0051081)2.39066946
189de novo posttranslational protein folding (GO:0051084)2.38516034
190protein targeting to mitochondrion (GO:0006626)2.38510271
191nucleobase biosynthetic process (GO:0046112)2.38462816
192pyrimidine nucleoside salvage (GO:0043097)2.38418494
193pyrimidine-containing compound salvage (GO:0008655)2.38418494
194biotin metabolic process (GO:0006768)2.38143154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.01806469
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.54364446
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.69027595
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.26243435
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.98589059
6E2F7_22180533_ChIP-Seq_HELA_Human4.55021046
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.34604536
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.31824634
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.84047510
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.77568153
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.24712304
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.16742939
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.88188160
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65706151
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.49374571
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.31931177
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.25981088
18* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.25931201
19ZNF263_19887448_ChIP-Seq_K562_Human2.24026048
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23736026
21* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22092641
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21951907
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21466035
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.17021531
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16978389
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16932412
27DCP1A_22483619_ChIP-Seq_HELA_Human2.14926823
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14643438
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11660080
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09286607
31XRN2_22483619_ChIP-Seq_HELA_Human2.06094185
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99962182
33* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.96999408
34* GABP_19822575_ChIP-Seq_HepG2_Human1.95454214
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95295726
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.92988414
37CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.85101785
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.82308221
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76446814
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74794139
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.74326134
42TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.68392683
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.64187669
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59218253
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57681091
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55685297
47KDM5A_27292631_Chip-Seq_BREAST_Human1.53447237
48TTF2_22483619_ChIP-Seq_HELA_Human1.51609941
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50625809
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50514518
51ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.49938686
52GATA4_25053715_ChIP-Seq_YYC3_Human1.48158377
53* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46513029
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46062428
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.45185378
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41254130
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39918529
58TFEB_21752829_ChIP-Seq_HELA_Human1.39177716
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38868669
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37316316
61HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35690385
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35516927
63* HNF4A_19822575_ChIP-Seq_HepG2_Human1.34432582
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32600539
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31852225
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.31647935
67FOXP3_21729870_ChIP-Seq_TREG_Human1.30165496
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29831586
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28136462
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28085674
71* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27266118
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26674802
73* SRF_21415370_ChIP-Seq_HL-1_Mouse1.25873080
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25517929
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25474594
76ATF3_27146783_Chip-Seq_COLON_Human1.24029948
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22867644
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21084325
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.19772397
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.18512577
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.17096886
82VDR_23849224_ChIP-Seq_CD4+_Human1.16984222
83CDX2_20551321_ChIP-Seq_CACO-2_Human1.16294945
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16020496
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15458598
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15286557
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14989147
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14571855
89RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14099324
90CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13675198
91* FOXA2_19822575_ChIP-Seq_HepG2_Human1.12948486
92TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12921110
93SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12108938
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.12100575
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.11519225
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.10742066
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10644200
98TBX5_21415370_ChIP-Seq_HL-1_Mouse1.10277482
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08996243
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08298417
101CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07895196
102* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07818456
103* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07597257
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06756317
105ELK1_19687146_ChIP-ChIP_HELA_Human1.06488264
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06375152
107EGR1_19374776_ChIP-ChIP_THP-1_Human1.06284631
108LXR_22292898_ChIP-Seq_THP-1_Human1.06034402
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04724823
110ESR1_21235772_ChIP-Seq_MCF-7_Human1.04519182
111TP63_17297297_ChIP-ChIP_HaCaT_Human1.04414637
112ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04326356
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04164707
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03058303
115TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00209464
116NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98771725
117KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97173660
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97173660
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97173660
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97091305
121CLOCK_20551151_ChIP-Seq_293T_Human0.96042368
122JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94766280
123CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93922241
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91167973
125* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90457283
126NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.90106567
127AR_21909140_ChIP-Seq_LNCAP_Human0.88941506
128GATA6_25053715_ChIP-Seq_YYC3_Human0.87924275
129SOX2_20726797_ChIP-Seq_SW620_Human0.87745227
130* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.87424351
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86802584
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84465074
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84465074
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83492949
135KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82886597
136EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82055389
137HTT_18923047_ChIP-ChIP_STHdh_Human0.79939775
138SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.79641867
139RARA_24833708_ChIP-Seq_LIVER_Mouse0.79401527
140KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78102305
141CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76777971
142FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75526869
143RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75037864
144P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74115093
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72572189
146SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.71978254
147CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.71733545
148RACK7_27058665_Chip-Seq_MCF-7_Human0.71299484
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70892466
150* SOX17_20123909_ChIP-Seq_XEN_Mouse0.70682838
151AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70500309
152RARB_24833708_ChIP-Seq_LIVER_Mouse0.68740628
153BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68314891
154FOXO3_23340844_ChIP-Seq_DLD1_Human0.67610005
155PPAR_26484153_Chip-Seq_NCI-H1993_Human0.67480467
156SRY_22984422_ChIP-ChIP_TESTIS_Rat0.67256474
157SOX2_18692474_ChIP-Seq_MESCs_Mouse0.66038053
158CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.65930951
159GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.65476524
160CSB_26484114_Chip-Seq_FIBROBLAST_Human0.65452426
161TCF3_18692474_ChIP-Seq_MESCs_Mouse0.64190692
162FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64106130
163GATA1_22025678_ChIP-Seq_K562_Human0.63884466
164TET1_21451524_ChIP-Seq_MESCs_Mouse0.63720662
165BCOR_27268052_Chip-Seq_Bcells_Human0.63564300
166NANOG_18555785_ChIP-Seq_MESCs_Mouse0.63116431
167SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.63084536
168AR_20517297_ChIP-Seq_VCAP_Human0.62255001
169EOMES_21245162_ChIP-Seq_HESCs_Human0.61173362
170CEBPB_22108803_ChIP-Seq_LS180_Human0.61154214

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.66936218
2MP0002139_abnormal_hepatobiliary_system6.84159872
3MP0003806_abnormal_nucleotide_metabolis5.29484064
4MP0005085_abnormal_gallbladder_physiolo4.90395413
5MP0005365_abnormal_bile_salt4.55709451
6MP0008875_abnormal_xenobiotic_pharmacok4.39748411
7MP0005332_abnormal_amino_acid3.82231823
8MP0003195_calcinosis3.52339071
9MP0003693_abnormal_embryo_hatching3.40874762
10MP0004019_abnormal_vitamin_homeostasis3.23405486
11MP0003252_abnormal_bile_duct3.13669315
12MP0009840_abnormal_foam_cell3.02448719
13MP0003111_abnormal_nucleus_morphology2.86528250
14MP0002877_abnormal_melanocyte_morpholog2.79394810
15MP0004957_abnormal_blastocyst_morpholog2.76882025
16MP0010094_abnormal_chromosome_stability2.58114187
17MP0004043_abnormal_pH_regulation2.55344458
18MP0001666_abnormal_nutrient_absorption2.42952187
19MP0003186_abnormal_redox_activity2.41792172
20MP0010329_abnormal_lipoprotein_level2.40856368
21MP0009643_abnormal_urine_homeostasis2.36408608
22MP0008007_abnormal_cellular_replicative2.34636311
23MP0008932_abnormal_embryonic_tissue2.34569497
24MP0003077_abnormal_cell_cycle2.17396866
25MP0004233_abnormal_muscle_weight2.04681034
26MP0008058_abnormal_DNA_repair2.04516156
27MP0010234_abnormal_vibrissa_follicle2.00053405
28MP0008438_abnormal_cutaneous_collagen1.95101187
29MP0005083_abnormal_biliary_tract1.94310150
30MP0003191_abnormal_cellular_cholesterol1.93680829
31MP0000358_abnormal_cell_content/1.92461465
32MP0002138_abnormal_hepatobiliary_system1.87416386
33MP0005636_abnormal_mineral_homeostasis1.82976258
34MP0003566_abnormal_cell_adhesion1.82871450
35MP0005319_abnormal_enzyme/_coenzyme1.78622762
36MP0003786_premature_aging1.77919978
37MP0002118_abnormal_lipid_homeostasis1.77305370
38MP0005451_abnormal_body_composition1.71539327
39MP0005584_abnormal_enzyme/coenzyme_acti1.67189652
40MP0010030_abnormal_orbit_morphology1.64644585
41MP0001764_abnormal_homeostasis1.64246694
42MP0004147_increased_porphyrin_level1.63760275
43MP0000609_abnormal_liver_physiology1.63099262
44MP0003656_abnormal_erythrocyte_physiolo1.58485279
45MP0005058_abnormal_lysosome_morphology1.56127500
46MP0001756_abnormal_urination1.53821753
47MP0001730_embryonic_growth_arrest1.51612529
48MP0004858_abnormal_nervous_system1.51575168
49MP0001849_ear_inflammation1.50781725
50MP0004272_abnormal_basement_membrane1.50219135
51MP0005257_abnormal_intraocular_pressure1.46798951
52MP0002060_abnormal_skin_morphology1.42654414
53MP0010352_gastrointestinal_tract_polyps1.40151459
54MP0002136_abnormal_kidney_physiology1.36868499
55MP0001765_abnormal_ion_homeostasis1.34165694
56MP0003315_abnormal_perineum_morphology1.33165454
57MP0000350_abnormal_cell_proliferation1.31391227
58MP0001216_abnormal_epidermal_layer1.24951944
59MP0002080_prenatal_lethality1.24608678
60MP0006036_abnormal_mitochondrial_physio1.23059960
61MP0000003_abnormal_adipose_tissue1.22502058
62MP0003011_delayed_dark_adaptation1.19119205
63MP0001881_abnormal_mammary_gland1.16814669
64MP0000372_irregular_coat_pigmentation1.09645788
65MP0009780_abnormal_chondrocyte_physiolo1.09182991
66MP0000537_abnormal_urethra_morphology1.08363640
67MP0005408_hypopigmentation1.07817938
68MP0000920_abnormal_myelination1.07693065
69MP0004264_abnormal_extraembryonic_tissu1.07507252
70MP0003123_paternal_imprinting1.07302248
71MP0000858_altered_metastatic_potential1.06659120
72MP0000678_abnormal_parathyroid_gland1.06528383
73MP0003690_abnormal_glial_cell1.05581612
74MP0009764_decreased_sensitivity_to1.03850218
75MP0005384_cellular_phenotype1.02877062
76MP0000598_abnormal_liver_morphology0.99640873
77MP0003950_abnormal_plasma_membrane0.99520790
78MP0001243_abnormal_dermal_layer0.99437347
79MP0000313_abnormal_cell_death0.99047199
80MP0003868_abnormal_feces_composition0.97446640
81MP0002876_abnormal_thyroid_physiology0.96954164
82MP0001697_abnormal_embryo_size0.94704414
83MP0000013_abnormal_adipose_tissue0.94320314
84MP0004185_abnormal_adipocyte_glucose0.92545984
85MP0000490_abnormal_crypts_of0.91437576
86MP0003718_maternal_effect0.90987706
87MP0003329_amyloid_beta_deposits0.90755250
88MP0008469_abnormal_protein_level0.90061512
89MP0000604_amyloidosis0.89600343
90MP0009765_abnormal_xenobiotic_induced0.89243150
91MP0003941_abnormal_skin_development0.88904741
92MP0005376_homeostasis/metabolism_phenot0.87584830
93MP0002019_abnormal_tumor_incidence0.87392023
94MP0000015_abnormal_ear_pigmentation0.87274791
95MP0005380_embryogenesis_phenotype0.86161891
96MP0001672_abnormal_embryogenesis/_devel0.86161891
97MP0005266_abnormal_metabolism0.85803982
98MP0005621_abnormal_cell_physiology0.83595747
99MP0005377_hearing/vestibular/ear_phenot0.83350257
100MP0003878_abnormal_ear_physiology0.83350257
101MP0009763_increased_sensitivity_to0.82329238
102MP0005330_cardiomyopathy0.82154423
103MP0005395_other_phenotype0.81719834
104MP0005084_abnormal_gallbladder_morpholo0.81659087
105MP0006035_abnormal_mitochondrial_morpho0.80759980
106MP0004885_abnormal_endolymph0.80412756
107MP0000627_abnormal_mammary_gland0.80182446
108MP0009642_abnormal_blood_homeostasis0.79503418
109MP0001853_heart_inflammation0.78886365
110MP0001727_abnormal_embryo_implantation0.78809209
111MP0005647_abnormal_sex_gland0.78666962
112MP0009697_abnormal_copulation0.77476978
113MP0010771_integument_phenotype0.77305952
114MP0001661_extended_life_span0.77109805
115MP0003984_embryonic_growth_retardation0.76394921
116MP0000343_altered_response_to0.75239682
117MP0002938_white_spotting0.75078142
118MP0002163_abnormal_gland_morphology0.71126307
119MP0002088_abnormal_embryonic_growth/wei0.69733213
120MP0002269_muscular_atrophy0.69032610
121MP0000467_abnormal_esophagus_morphology0.68552824
122MP0000647_abnormal_sebaceous_gland0.68128514
123MP0005670_abnormal_white_adipose0.67908515
124MP0006082_CNS_inflammation0.64158290
125MP0002168_other_aberrant_phenotype0.60768013
126MP0002796_impaired_skin_barrier0.59752209
127MP0003638_abnormal_response/metabolism_0.56122765
128MP0008260_abnormal_autophagy0.55374638
129MP0008873_increased_physiological_sensi0.54823306
130MP0002295_abnormal_pulmonary_circulatio0.54137860
131MP0001542_abnormal_bone_strength0.52952176
132MP0005535_abnormal_body_temperature0.51250027
133MP0005666_abnormal_adipose_tissue0.50073772
134MP0005501_abnormal_skin_physiology0.48860727
135MP0005220_abnormal_exocrine_pancreas0.48623967
136MP0002132_abnormal_respiratory_system0.48305005
137MP0001958_emphysema0.47546395
138MP0003705_abnormal_hypodermis_morpholog0.47310740
139MP0004782_abnormal_surfactant_physiolog0.44517280
140MP0008872_abnormal_physiological_respon0.43949198
141MP0000462_abnormal_digestive_system0.43354966
142MP0000230_abnormal_systemic_arterial0.43044887
143MP0002135_abnormal_kidney_morphology0.42824345
144MP0002078_abnormal_glucose_homeostasis0.41705808
145MP0003453_abnormal_keratinocyte_physiol0.41440109
146MP0005023_abnormal_wound_healing0.38769990
147MP0002971_abnormal_brown_adipose0.38469793
148MP0005075_abnormal_melanosome_morpholog0.38202548
149MP0005165_increased_susceptibility_to0.38074247
150MP0003075_altered_response_to0.37422175
151MP0000538_abnormal_urinary_bladder0.37367364
152MP0005464_abnormal_platelet_physiology0.36955878
153MP0002928_abnormal_bile_duct0.35428552
154MP0004381_abnormal_hair_follicle0.34389388
155MP0005334_abnormal_fat_pad0.34372421
156MP0001663_abnormal_digestive_system0.34255210
157MP0001845_abnormal_inflammatory_respons0.34130516
158MP0000477_abnormal_intestine_morphology0.32322434
159MP0004142_abnormal_muscle_tone0.32114792
160MP0005381_digestive/alimentary_phenotyp0.31142569
161MP0003172_abnormal_lysosome_physiology0.30787185

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.52447182
2Intrahepatic cholestasis (HP:0001406)5.41385878
3Hyperglycinuria (HP:0003108)4.89681404
4Abnormality of glutamine family amino acid metabolism (HP:0010902)4.87672983
5Abnormality of monocarboxylic acid metabolism (HP:0010996)4.59807989
6Abnormality of serine family amino acid metabolism (HP:0010894)4.55086072
7Abnormality of glycine metabolism (HP:0010895)4.55086072
8Xanthomatosis (HP:0000991)4.41269858
9Abnormal gallbladder physiology (HP:0012438)4.30383938
10Cholecystitis (HP:0001082)4.30383938
11Abnormality of aspartate family amino acid metabolism (HP:0010899)4.12652623
12Hyperammonemia (HP:0001987)4.06700547
13Gout (HP:0001997)4.06102524
14Hypobetalipoproteinemia (HP:0003563)3.90012654
15Proximal tubulopathy (HP:0000114)3.85807859
16Hyperglycinemia (HP:0002154)3.83510766
17Deep venous thrombosis (HP:0002625)3.80453427
18Abnormality of sulfur amino acid metabolism (HP:0004339)3.73822712
19Abnormality of fatty-acid metabolism (HP:0004359)3.62060506
20Generalized aminoaciduria (HP:0002909)3.61985969
21Ketosis (HP:0001946)3.59518500
22Metabolic alkalosis (HP:0200114)3.50468347
23Alkalosis (HP:0001948)3.45304228
24Prolonged partial thromboplastin time (HP:0003645)3.41216046
25Hyperlipoproteinemia (HP:0010980)3.39478076
26Hyperactive renin-angiotensin system (HP:0000841)3.39141531
27Abnormality of purine metabolism (HP:0004352)3.36720343
28Increased circulating renin level (HP:0000848)3.34596818
29Hypokalemic alkalosis (HP:0001949)3.29728163
30Dicarboxylic aciduria (HP:0003215)3.23896925
31Abnormality of dicarboxylic acid metabolism (HP:0010995)3.23896925
32Abnormality of chloride homeostasis (HP:0011422)3.22820318
33Hypomagnesemia (HP:0002917)3.21310295
34Abnormality of methionine metabolism (HP:0010901)3.19410745
35Fat malabsorption (HP:0002630)3.17945452
36Abnormality of nucleobase metabolism (HP:0010932)3.16549732
37Increased purine levels (HP:0004368)3.14050133
38Hyperuricemia (HP:0002149)3.14050133
39Lethargy (HP:0001254)3.09511864
40Short nail (HP:0001799)3.05097806
41Ketoacidosis (HP:0001993)3.02293724
42Vascular calcification (HP:0004934)3.01482589
43Abnormality of urine glucose concentration (HP:0011016)3.00826469
44Glycosuria (HP:0003076)3.00826469
45Abnormal mitochondria in muscle tissue (HP:0008316)3.00691480
46Hypoglycemic coma (HP:0001325)2.98096147
47Vertebral compression fractures (HP:0002953)2.97710907
48Ileus (HP:0002595)2.91606540
49Abnormality of serum amino acid levels (HP:0003112)2.91580560
50* Metabolic acidosis (HP:0001942)2.86442866
51Delayed CNS myelination (HP:0002188)2.85854657
52Abnormal urine output (HP:0012590)2.83703902
53Hypolipoproteinemia (HP:0010981)2.83684417
54Microvesicular hepatic steatosis (HP:0001414)2.82893983
55Upper limb muscle weakness (HP:0003484)2.80043901
56Hypokinesia (HP:0002375)2.79769966
57Polyuria (HP:0000103)2.79386357
58Premature rupture of membranes (HP:0001788)2.76859517
59Abnormality of pyrimidine metabolism (HP:0004353)2.76208510
60Acute necrotizing encephalopathy (HP:0006965)2.75080126
61Abnormality of magnesium homeostasis (HP:0004921)2.74943467
62Abnormality of glycolipid metabolism (HP:0010969)2.73566896
63Abnormality of liposaccharide metabolism (HP:0010968)2.73566896
64Abnormality of glycosphingolipid metabolism (HP:0004343)2.73566896
65Type I transferrin isoform profile (HP:0003642)2.73322920
66Rickets (HP:0002748)2.72996212
67Abnormality of proline metabolism (HP:0010907)2.68914896
68Hydroxyprolinuria (HP:0003080)2.68914896
69Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.67735410
70Vomiting (HP:0002013)2.65053165
71Cardiovascular calcification (HP:0011915)2.64838658
72Abnormality of renal excretion (HP:0011036)2.63859489
73Joint hemorrhage (HP:0005261)2.62333827
74Hyperbilirubinemia (HP:0002904)2.62005510
75Entropion (HP:0000621)2.61561467
76Reticulocytopenia (HP:0001896)2.57518091
77Malnutrition (HP:0004395)2.54053151
78Rough bone trabeculation (HP:0100670)2.53145812
79Cerebral edema (HP:0002181)2.52350375
80Prolonged neonatal jaundice (HP:0006579)2.51739374
81Steatorrhea (HP:0002570)2.51241287
82Increased serum pyruvate (HP:0003542)2.48939192
83Abnormality of glycolysis (HP:0004366)2.48939192
84Abnormal enzyme/coenzyme activity (HP:0012379)2.48814586
85Hepatocellular necrosis (HP:0001404)2.48173076
86Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47171644
87Hepatic necrosis (HP:0002605)2.46570310
88Vacuolated lymphocytes (HP:0001922)2.46415445
89J-shaped sella turcica (HP:0002680)2.41919012
90Irritability (HP:0000737)2.41535378
91Conjugated hyperbilirubinemia (HP:0002908)2.41050567
92Renal salt wasting (HP:0000127)2.40309913
93Progressive muscle weakness (HP:0003323)2.39013349
94Epidermoid cyst (HP:0200040)2.38420858
95Complement deficiency (HP:0004431)2.36991389
96Abnormality of the common coagulation pathway (HP:0010990)2.35218876
97Mitochondrial inheritance (HP:0001427)2.35074859
98Ragged-red muscle fibers (HP:0003200)2.34703099
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.33084141
100Abnormality of alkaline phosphatase activity (HP:0004379)2.32811214
101Orthostatic hypotension (HP:0001278)2.32172683
102Trismus (HP:0000211)2.31258446
103Cholelithiasis (HP:0001081)2.29168155
104Hypoalphalipoproteinemia (HP:0003233)2.29081924
105Increased CSF lactate (HP:0002490)2.27361585
106Opisthotonus (HP:0002179)2.27328197
107Hand muscle atrophy (HP:0009130)2.26517273
108Abnormality of the umbilical cord (HP:0010881)2.26471011
109Reduced antithrombin III activity (HP:0001976)2.25201395
110Nausea (HP:0002018)2.23568616
111Abnormal protein glycosylation (HP:0012346)2.23513760
112Abnormal glycosylation (HP:0012345)2.23513760
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23513760
114Abnormal protein N-linked glycosylation (HP:0012347)2.23513760
115Abnormality of reticulocytes (HP:0004312)2.23205649
116Upper limb amyotrophy (HP:0009129)2.20748861
117Distal upper limb amyotrophy (HP:0007149)2.20748861
118Hyperaldosteronism (HP:0000859)2.18974202
119Confusion (HP:0001289)2.18530643
120Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17204796
121Methylmalonic aciduria (HP:0012120)2.16121491
122Abnormality of the intrinsic pathway (HP:0010989)2.15911780
123Abnormal gallbladder morphology (HP:0012437)2.14963170
124Spastic paraparesis (HP:0002313)2.13553512
125Abnormal trabecular bone morphology (HP:0100671)2.11013857
126Hyperphosphaturia (HP:0003109)2.10918685
127Hyperthyroidism (HP:0000836)2.10287937
128Exercise intolerance (HP:0003546)2.09609232
129Testicular atrophy (HP:0000029)2.08893933
130Abnormality of the distal phalanges of the toes (HP:0010182)2.08883090
131Abnormality of vitamin metabolism (HP:0100508)2.08566626
132Abnormal drinking behavior (HP:0030082)2.08014688
133Polydipsia (HP:0001959)2.08014688
134Reticulocytosis (HP:0001923)2.06952386
135Elevated alkaline phosphatase (HP:0003155)2.06065737
136Abnormality of the anterior horn cell (HP:0006802)2.05589435
137Degeneration of anterior horn cells (HP:0002398)2.05589435
138Renal Fanconi syndrome (HP:0001994)2.02439300
139Abnormality of the tricuspid valve (HP:0001702)2.00798656
140Acute encephalopathy (HP:0006846)2.00574676
141Abnormality of the gallbladder (HP:0005264)2.00488529
142Hepatocellular carcinoma (HP:0001402)1.99771604
143Megaloblastic anemia (HP:0001889)1.99706287
144Secondary amenorrhea (HP:0000869)1.99668455
145Nephrolithiasis (HP:0000787)1.99549419
146Sparse eyelashes (HP:0000653)1.99176437
147Abnormality of renin-angiotensin system (HP:0000847)1.98706400
148Hypercholesterolemia (HP:0003124)1.98662622
149Achilles tendon contracture (HP:0001771)1.98183876
150Abnormality of the Achilles tendon (HP:0005109)1.98001201
151Abnormal tarsal ossification (HP:0008369)1.97638523
152Abnormalities of placenta or umbilical cord (HP:0001194)1.97212296
153Hypophosphatemic rickets (HP:0004912)1.96668211
154Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96339447
155Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96339447
156Abnormality of carpal bone ossification (HP:0006257)1.96161093
157Tetany (HP:0001281)1.95667252
158Widely patent fontanelles and sutures (HP:0004492)1.95622350
159Hypochromic microcytic anemia (HP:0004840)1.94951649
160Hypertensive crisis (HP:0100735)1.94889194
161Nuclear cataract (HP:0100018)1.94195905
162Glucose intolerance (HP:0000833)1.93539075
163Increased hepatocellular lipid droplets (HP:0006565)1.93530939
164Enlarged kidneys (HP:0000105)1.93390712
165Fasciculations (HP:0002380)1.92767817
166Progressive macrocephaly (HP:0004481)1.91824354
167Lactic acidosis (HP:0003128)1.87537709
168Increased serum lactate (HP:0002151)1.86441488
169Lipid accumulation in hepatocytes (HP:0006561)1.86334106
170Increased intramyocellular lipid droplets (HP:0012240)1.84705326
171Dysostosis multiplex (HP:0000943)1.82781828
172Microretrognathia (HP:0000308)1.81763825
173Abnormal hair laboratory examination (HP:0003328)1.81402187
174Seborrheic dermatitis (HP:0001051)1.81265806
175Progressive neurologic deterioration (HP:0002344)1.81195801
176Abnormal umbilical cord blood vessels (HP:0011403)1.79840467
177Single umbilical artery (HP:0001195)1.79840467
178Abnormality of the fetal cardiovascular system (HP:0010948)1.79840467
179Reduced subcutaneous adipose tissue (HP:0003758)1.78662897
180Cervical subluxation (HP:0003308)1.76516742
181Respiratory failure (HP:0002878)1.76163745
182Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75460586
183Poikiloderma (HP:0001029)1.73845710
184Increased muscle lipid content (HP:0009058)1.72580684
185Truncus arteriosus (HP:0001660)1.72335455
186Congenital ichthyosiform erythroderma (HP:0007431)1.70360164
187Hepatosplenomegaly (HP:0001433)1.67420638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR15.14884071
2BCKDK4.53061075
3WNK44.52346278
4STK394.48249960
5VRK23.69328457
6PBK3.52982366
7WNK33.45900437
8MET2.77368662
9PIK3CG2.67577288
10TESK12.60081926
11EPHB12.46125091
12MST42.34884586
13EPHA22.30487245
14SCYL22.14568510
15MST1R2.11476807
16SMG12.08026132
17ERBB42.05785104
18STK38L1.87449426
19IRAK31.81248350
20FGFR41.71803149
21TRIB31.60629239
22ERN11.59084524
23LIMK11.58986802
24PIM21.50753302
25ABL21.44671569
26SRPK11.39609479
27BRSK11.33571031
28CDK81.30319312
29PRPF4B1.26573807
30MAP3K121.25640658
31NME21.24660603
32DAPK11.22872836
33CDC71.20299760
34TRIM281.20255586
35MAP3K111.19924512
36PDK21.18574770
37PINK11.18456254
38BLK1.17075792
39WNK11.16988703
40WEE11.16663551
41CDK71.16624540
42MAPK151.15577232
43LMTK21.11710456
44TSSK61.11622616
45ILK1.08112314
46MAP3K141.06393831
47SIK11.00999823
48CCNB10.99247924
49MAPK110.98542488
50PRKG20.98103701
51TESK20.97587573
52AURKA0.97434475
53MAP2K30.96772143
54ICK0.96408647
55AURKB0.94050078
56STK100.92965673
57NME10.90990663
58VRK10.88237304
59PKN20.88225398
60BCR0.86684427
61PDK30.85981829
62PDK40.85981829
63STK160.83549260
64CHEK20.80950294
65CAMK2G0.80939713
66MAP2K20.80932297
67PLK10.77404628
68MATK0.76738918
69SGK2230.75973798
70SGK4940.75973798
71PKN10.75687662
72MAP3K60.75659189
73CLK10.75451343
74PTK20.72235025
75SIK30.72007835
76PLK30.71468408
77RPS6KB20.71051953
78PRKD30.68439142
79ATR0.68013076
80GSK3A0.66240804
81MYLK0.65018386
82MUSK0.64192125
83EIF2AK30.63796215
84MAP3K30.63048007
85TRPM70.62536663
86TBK10.62001794
87CSF1R0.61799835
88GRK10.61367349
89AKT30.58439150
90BRSK20.58369246
91DAPK30.57939156
92NEK10.57460920
93BUB10.56071750
94GRK60.55573524
95EIF2AK10.55148472
96RPS6KA40.54948766
97CSNK1G30.54028758
98CHEK10.53563064
99EPHB20.53412977
100DYRK1B0.52566903
101BMX0.52405960
102BRAF0.51822054
103ARAF0.51167212
104TTK0.50893519
105PAK20.50185205
106FLT30.49122812
107CSK0.48565705
108AKT20.47631520
109MAPKAPK30.46794936
110PIM10.46791342
111CSNK1G10.46741215
112MAP2K60.45600929
113CSNK2A20.45175101
114CDK140.44635004
115PRKCI0.44467561
116IKBKB0.42990074
117INSRR0.41814630
118MAPKAPK50.41573462
119IRAK20.41204430
120NEK20.41020800
121PAK40.39426478
122CAMK2B0.39145196
123MAPK70.39117531
124DDR20.38694928
125PTK60.38536568
126RAF10.38222548
127CSNK2A10.38067006
128PRKCQ0.38030183
129ERBB20.37726996
130PDGFRA0.37506784
131PDPK10.37462386
132CDK180.35468741
133PLK40.35358324
134CSNK1A1L0.35115782
135TYK20.34946997
136PRKCD0.34373081
137CDK90.34231315
138CDK11A0.32630067
139PRKACG0.32276470
140LRRK20.31468769
141CAMK2D0.31372462
142MAP3K80.31319413
143FGFR20.29737391
144PRKAA20.29070631
145FGR0.28925350
146PRKAA10.28663129
147PAK10.28341735
148FRK0.27246764
149STK40.26801674
150IRAK10.26641314
151PRKCZ0.24769745
152TAOK20.24111457
153KDR0.23874504
154PIK3CA0.23289684
155NEK90.23246105
156NTRK10.23038768

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.10024113
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.01027250
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.00505625
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75319992
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.71786007
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.69433683
7Nitrogen metabolism_Homo sapiens_hsa009102.52838073
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49035686
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.47049515
10Butanoate metabolism_Homo sapiens_hsa006502.46912554
11Tryptophan metabolism_Homo sapiens_hsa003802.33648833
12Fatty acid degradation_Homo sapiens_hsa000712.31620585
13Base excision repair_Homo sapiens_hsa034102.28963030
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.27875374
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.27380051
16Propanoate metabolism_Homo sapiens_hsa006402.26977631
17Arginine biosynthesis_Homo sapiens_hsa002202.26793141
18Mismatch repair_Homo sapiens_hsa034302.24658204
19Peroxisome_Homo sapiens_hsa041462.21522026
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.17335453
21Sulfur metabolism_Homo sapiens_hsa009202.03216230
22Histidine metabolism_Homo sapiens_hsa003402.01957136
23Steroid biosynthesis_Homo sapiens_hsa001001.93399065
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92029799
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.84967898
26Fatty acid elongation_Homo sapiens_hsa000621.82332065
27Ribosome_Homo sapiens_hsa030101.77536342
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76024769
29Folate biosynthesis_Homo sapiens_hsa007901.75925240
30Fatty acid metabolism_Homo sapiens_hsa012121.75489891
31beta-Alanine metabolism_Homo sapiens_hsa004101.74852183
32Nucleotide excision repair_Homo sapiens_hsa034201.72778511
33Pyruvate metabolism_Homo sapiens_hsa006201.70503271
34Chemical carcinogenesis_Homo sapiens_hsa052041.69999674
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66073551
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.61662517
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60788109
38Complement and coagulation cascades_Homo sapiens_hsa046101.57901136
39Vitamin digestion and absorption_Homo sapiens_hsa049771.56492468
40PPAR signaling pathway_Homo sapiens_hsa033201.53578165
41* Glutathione metabolism_Homo sapiens_hsa004801.53236354
42Arginine and proline metabolism_Homo sapiens_hsa003301.52583077
43N-Glycan biosynthesis_Homo sapiens_hsa005101.47589361
44Carbon metabolism_Homo sapiens_hsa012001.47025621
45Selenocompound metabolism_Homo sapiens_hsa004501.43892727
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.41773785
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39960855
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37845899
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37402695
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37108376
51Vitamin B6 metabolism_Homo sapiens_hsa007501.36619358
52Non-homologous end-joining_Homo sapiens_hsa034501.36465723
53Vibrio cholerae infection_Homo sapiens_hsa051101.36161584
54Biosynthesis of amino acids_Homo sapiens_hsa012301.35852666
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.33717909
56Retinol metabolism_Homo sapiens_hsa008301.31876359
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.29662780
58Bile secretion_Homo sapiens_hsa049761.26152414
59RNA polymerase_Homo sapiens_hsa030201.25043585
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22868406
61Spliceosome_Homo sapiens_hsa030401.19520110
62Phenylalanine metabolism_Homo sapiens_hsa003601.19517267
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19229114
64* Cysteine and methionine metabolism_Homo sapiens_hsa002701.19189823
65RNA transport_Homo sapiens_hsa030131.18263796
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17708826
67Homologous recombination_Homo sapiens_hsa034401.16732917
68Starch and sucrose metabolism_Homo sapiens_hsa005001.09071158
69Tyrosine metabolism_Homo sapiens_hsa003501.04755026
70Caffeine metabolism_Homo sapiens_hsa002320.99680268
71Cell cycle_Homo sapiens_hsa041100.97779342
72Fructose and mannose metabolism_Homo sapiens_hsa000510.96528046
73Pentose phosphate pathway_Homo sapiens_hsa000300.95130322
74Fat digestion and absorption_Homo sapiens_hsa049750.94277743
75Sulfur relay system_Homo sapiens_hsa041220.92935336
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92575162
77Staphylococcus aureus infection_Homo sapiens_hsa051500.85681533
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82933069
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81775377
80Fanconi anemia pathway_Homo sapiens_hsa034600.80599939
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.76591027
82Glycerolipid metabolism_Homo sapiens_hsa005610.76342694
83* Metabolic pathways_Homo sapiens_hsa011000.74927010
84ABC transporters_Homo sapiens_hsa020100.74533610
85Purine metabolism_Homo sapiens_hsa002300.72668846
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.70931200
87Shigellosis_Homo sapiens_hsa051310.67645920
88Mineral absorption_Homo sapiens_hsa049780.65541100
89Oxidative phosphorylation_Homo sapiens_hsa001900.63729103
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61996960
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60694138
92Arachidonic acid metabolism_Homo sapiens_hsa005900.59370913
93One carbon pool by folate_Homo sapiens_hsa006700.59220983
94Lysine degradation_Homo sapiens_hsa003100.55948676
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55747784
96Bladder cancer_Homo sapiens_hsa052190.55385374
97Linoleic acid metabolism_Homo sapiens_hsa005910.50211032
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46194378
99Proteasome_Homo sapiens_hsa030500.41356901
100Galactose metabolism_Homo sapiens_hsa000520.39988424
101Other glycan degradation_Homo sapiens_hsa005110.38148123
102p53 signaling pathway_Homo sapiens_hsa041150.37524318
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36163337
104Renin-angiotensin system_Homo sapiens_hsa046140.35948120
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33960259
106Collecting duct acid secretion_Homo sapiens_hsa049660.33916098
107Parkinsons disease_Homo sapiens_hsa050120.32528000
108Fatty acid biosynthesis_Homo sapiens_hsa000610.29594071
109Ether lipid metabolism_Homo sapiens_hsa005650.29509454
110Salmonella infection_Homo sapiens_hsa051320.28457133
111mRNA surveillance pathway_Homo sapiens_hsa030150.28023077
112Lysosome_Homo sapiens_hsa041420.26587276
113Thyroid cancer_Homo sapiens_hsa052160.26067422
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24759148
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.20913918
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20884511
117Oocyte meiosis_Homo sapiens_hsa041140.19275281
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18000847
119Pancreatic cancer_Homo sapiens_hsa052120.16929634
120RNA degradation_Homo sapiens_hsa030180.16685046
121Protein digestion and absorption_Homo sapiens_hsa049740.12812641
122Sphingolipid metabolism_Homo sapiens_hsa006000.09955917
123Regulation of autophagy_Homo sapiens_hsa041400.07670603
124Alzheimers disease_Homo sapiens_hsa050100.06714644
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06510732
126Huntingtons disease_Homo sapiens_hsa050160.02303921
127Pyrimidine metabolism_Homo sapiens_hsa002400.02047326
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.01046802
129Protein export_Homo sapiens_hsa03060-0.0667974
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0611322
131Hepatitis C_Homo sapiens_hsa05160-0.0605816
132Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0417403
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0195270

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