GSTA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.12653796
2maintenance of gastrointestinal epithelium (GO:0030277)7.31412764
3axonemal dynein complex assembly (GO:0070286)7.14061590
4intestinal cholesterol absorption (GO:0030299)6.60487442
5flavonoid metabolic process (GO:0009812)6.50927304
6response to nitrosative stress (GO:0051409)5.86492174
7cilium or flagellum-dependent cell motility (GO:0001539)5.85326554
8cellular glucuronidation (GO:0052695)5.75711820
9epithelial structure maintenance (GO:0010669)5.50537454
10xenobiotic catabolic process (GO:0042178)5.30587429
11digestion (GO:0007586)5.28974686
12* glutathione derivative biosynthetic process (GO:1901687)5.27134557
13* glutathione derivative metabolic process (GO:1901685)5.27134557
14digestive system process (GO:0022600)5.25582716
15uronic acid metabolic process (GO:0006063)5.18355486
16glucuronate metabolic process (GO:0019585)5.18355486
17bundle of His cell to Purkinje myocyte communication (GO:0086069)5.15042565
18triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.01151901
19omega-hydroxylase P450 pathway (GO:0097267)5.00831551
20cilium movement (GO:0003341)4.88488116
21regulation of protein activation cascade (GO:2000257)4.86324755
22purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.79778843
233-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.79778843
24drug catabolic process (GO:0042737)4.75374345
25sulfation (GO:0051923)4.68716995
26motile cilium assembly (GO:0044458)4.60533580
27bile acid biosynthetic process (GO:0006699)4.57648849
28fructose metabolic process (GO:0006000)4.56086947
29regulation of complement activation (GO:0030449)4.55035302
30regulation of fibrinolysis (GO:0051917)4.50019540
31urea cycle (GO:0000050)4.49535764
32urea metabolic process (GO:0019627)4.49535764
33regulation of triglyceride catabolic process (GO:0010896)4.48061295
34negative regulation of sterol transport (GO:0032372)4.45684179
35negative regulation of cholesterol transport (GO:0032375)4.45684179
36phenylpropanoid metabolic process (GO:0009698)4.45157655
37protein autoprocessing (GO:0016540)4.40928495
38polyketide metabolic process (GO:0030638)4.40433492
39doxorubicin metabolic process (GO:0044598)4.40433492
40daunorubicin metabolic process (GO:0044597)4.40433492
41phospholipid efflux (GO:0033700)4.40133524
42vitamin transmembrane transport (GO:0035461)4.40034786
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.37163117
44sulfur amino acid catabolic process (GO:0000098)4.33023877
45negative regulation of fibrinolysis (GO:0051918)4.32075109
46complement activation, alternative pathway (GO:0006957)4.31403301
47cysteine metabolic process (GO:0006534)4.29333740
48regulation of cholesterol esterification (GO:0010872)4.28441288
49peptidyl-glutamic acid carboxylation (GO:0017187)4.27779095
50protein carboxylation (GO:0018214)4.27779095
51negative regulation of digestive system process (GO:0060457)4.25465578
52very-low-density lipoprotein particle assembly (GO:0034379)4.25118066
53plasma lipoprotein particle assembly (GO:0034377)4.24443188
54NADH metabolic process (GO:0006734)4.18687303
55primary alcohol metabolic process (GO:0034308)4.15291276
56epithelial cilium movement (GO:0003351)4.10940420
57regulation of cholesterol homeostasis (GO:2000188)4.10206867
58progesterone metabolic process (GO:0042448)4.09010111
59protein-lipid complex assembly (GO:0065005)4.07960405
60nitrogen cycle metabolic process (GO:0071941)4.02824019
61lipoprotein metabolic process (GO:0042157)3.99917820
62fat-soluble vitamin biosynthetic process (GO:0042362)3.99698265
63aminoglycoside antibiotic metabolic process (GO:0030647)3.96230207
64fibrinolysis (GO:0042730)3.92479316
65cholesterol efflux (GO:0033344)3.89538470
66negative regulation of lipase activity (GO:0060192)3.88587590
67angiotensin maturation (GO:0002003)3.87402698
68cholesterol homeostasis (GO:0042632)3.85935308
69high-density lipoprotein particle remodeling (GO:0034375)3.85346719
70sterol homeostasis (GO:0055092)3.83726863
71L-ascorbic acid metabolic process (GO:0019852)3.81121297
72reverse cholesterol transport (GO:0043691)3.77009616
73positive regulation of triglyceride lipase activity (GO:0061365)3.76671333
74positive regulation of lipoprotein lipase activity (GO:0051006)3.76671333
75O-glycan processing (GO:0016266)3.75871310
76diacylglycerol metabolic process (GO:0046339)3.66168123
77bile acid and bile salt transport (GO:0015721)3.65567642
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.65109877
79L-phenylalanine metabolic process (GO:0006558)3.65109877
80homocysteine metabolic process (GO:0050667)3.64894715
81oxidative demethylation (GO:0070989)3.63552288
82plasma lipoprotein particle remodeling (GO:0034369)3.61457882
83protein-lipid complex remodeling (GO:0034368)3.61457882
84macromolecular complex remodeling (GO:0034367)3.61457882
85lipoprotein transport (GO:0042953)3.60641821
86drug metabolic process (GO:0017144)3.56016490
87acylglycerol homeostasis (GO:0055090)3.55679966
88triglyceride homeostasis (GO:0070328)3.55679966
89hormone catabolic process (GO:0042447)3.55478854
90L-phenylalanine catabolic process (GO:0006559)3.50872886
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.50872886
92regulation of proton transport (GO:0010155)3.47353880
93negative regulation of blood coagulation (GO:0030195)3.45040070
94negative regulation of hemostasis (GO:1900047)3.45040070
95epoxygenase P450 pathway (GO:0019373)3.42571794
96diterpenoid biosynthetic process (GO:0016102)3.42559467
97ethanol metabolic process (GO:0006067)3.41817813
98blood coagulation, intrinsic pathway (GO:0007597)3.40136546
99exogenous drug catabolic process (GO:0042738)3.39457768
100phospholipid homeostasis (GO:0055091)3.39138538
101* xenobiotic metabolic process (GO:0006805)3.39119236
102alkaloid metabolic process (GO:0009820)3.36953451
103androgen biosynthetic process (GO:0006702)3.36020339
104* glutathione metabolic process (GO:0006749)3.35690762
105androgen metabolic process (GO:0008209)3.34097760
106regulation of bile acid biosynthetic process (GO:0070857)3.31883200
107ethanol oxidation (GO:0006069)3.31567614
108vitamin A metabolic process (GO:0006776)3.30370119
109response to iron ion (GO:0010039)3.27719330
110alpha-linolenic acid metabolic process (GO:0036109)3.25567063
111negative regulation of coagulation (GO:0050819)3.20930287
112positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.20757413
113negative regulation of humoral immune response (GO:0002921)3.19588504
114plasma lipoprotein particle clearance (GO:0034381)3.16896656
115fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.16736406
116drug transport (GO:0015893)3.16682602
117carnitine metabolic process (GO:0009437)3.15996406
118regulation of humoral immune response (GO:0002920)3.13377328
119sterol transport (GO:0015918)3.13264314
120cholesterol transport (GO:0030301)3.13264314
121heme transport (GO:0015886)3.09983489
122positive regulation of fatty acid biosynthetic process (GO:0045723)3.09914895
123plasma lipoprotein particle organization (GO:0071827)3.09288317
124protein-lipid complex subunit organization (GO:0071825)3.07147015
125regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.06358806
126lysine metabolic process (GO:0006553)3.05744984
127lysine catabolic process (GO:0006554)3.05744984
128benzene-containing compound metabolic process (GO:0042537)3.05528620
129lipid homeostasis (GO:0055088)3.05247869
130positive regulation of lipid catabolic process (GO:0050996)3.02594685
131glyoxylate metabolic process (GO:0046487)3.02481171
132drug transmembrane transport (GO:0006855)2.99595999
133thyroid hormone metabolic process (GO:0042403)2.98089895
134aromatic amino acid family catabolic process (GO:0009074)2.97944133
135positive regulation of triglyceride metabolic process (GO:0090208)2.97191429
136amino-acid betaine metabolic process (GO:0006577)2.97145096
137primary alcohol catabolic process (GO:0034310)2.95466207
138bile acid metabolic process (GO:0008206)2.94390341
139intestinal epithelial cell development (GO:0060576)2.92618465
140negative regulation of fatty acid metabolic process (GO:0045922)2.92588353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.11911167
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.34070608
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.12405139
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.72011582
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.45228984
6* SOX2_27498859_Chip-Seq_STOMACH_Mouse4.28365787
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.22278299
8* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.62558063
9ESR1_15608294_ChIP-ChIP_MCF-7_Human3.41719247
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.32623123
11* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.15809809
12CDX2_20551321_ChIP-Seq_CACO-2_Human3.14626832
13GATA4_25053715_ChIP-Seq_YYC3_Human3.02639876
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.84855745
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.78453072
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.76606939
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.57171926
18GATA6_25053715_ChIP-Seq_YYC3_Human2.43021592
19SOX2_20726797_ChIP-Seq_SW620_Human2.27107667
20PPAR_26484153_Chip-Seq_NCI-H1993_Human2.20408721
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.14293892
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.13847900
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00795899
24CLOCK_20551151_ChIP-Seq_293T_Human1.88400409
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81021657
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.80509652
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75288828
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74924668
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.67803606
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65768774
31KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64417878
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.61381478
33ZNF263_19887448_ChIP-Seq_K562_Human1.59593503
34GATA1_22025678_ChIP-Seq_K562_Human1.51343529
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48980552
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48846812
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48482459
38FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.47358959
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.46471862
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46463910
41* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45874535
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44887175
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43764814
44PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.41849943
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.40896536
46TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.40888751
47ATF3_27146783_Chip-Seq_COLON_Human1.37420813
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36355674
49RACK7_27058665_Chip-Seq_MCF-7_Human1.36328844
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34227825
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30803580
52KLF5_25053715_ChIP-Seq_YYC3_Human1.28504070
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26984563
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.25563292
55* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23235576
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21525948
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20988732
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.20912919
59GATA3_24758297_ChIP-Seq_MCF-7_Human1.20821422
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20159883
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20159883
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19969511
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17956979
64EGR1_19032775_ChIP-ChIP_M12_Human1.16915080
65DROSHA_22980978_ChIP-Seq_HELA_Human1.16557398
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16437850
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10679611
68HNFA_21074721_ChIP-Seq_CACO-2_Human1.10534124
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10029176
70RAD21_21589869_ChIP-Seq_MESCs_Mouse1.09687032
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08405553
72CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07183673
73AR_21909140_ChIP-Seq_LNCAP_Human1.06154243
74LXR_22292898_ChIP-Seq_THP-1_Human1.05653835
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.04445425
76TP63_23658742_ChIP-Seq_EP156T_Human1.03813250
77PHF8_20622853_ChIP-Seq_HELA_Human1.03190885
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02949566
79JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00401447
80P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99246888
81STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97878293
82ETV1_20927104_ChIP-Seq_GIST48_Human0.95138605
83AR_20517297_ChIP-Seq_VCAP_Human0.94374774
84TP53_18474530_ChIP-ChIP_U2OS_Human0.93676184
85ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93320487
86FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92829045
87CTCF_27219007_Chip-Seq_Bcells_Human0.92488265
88PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.91895947
89GATA1_19941826_ChIP-Seq_K562_Human0.91851944
90CBP_21632823_ChIP-Seq_H3396_Human0.90888115
91TCF4_18268006_ChIP-ChIP_LS174T_Human0.90118114
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89695670
93GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.89528258
94JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89061935
95NFYA_21822215_ChIP-Seq_K562_Human0.86163927
96IRF8_22096565_ChIP-ChIP_GC-B_Human0.85882422
97CBX2_22325352_ChIP-Seq_293T-Rex_Human0.84815876
98GATA6_21074721_ChIP-Seq_CACO-2_Human0.84711821
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.83879810
100* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.83336149
101GATA2_19941826_ChIP-Seq_K562_Human0.83218293
102CREB1_26743006_Chip-Seq_LNCaP_Human0.83170012
103SOX2_21211035_ChIP-Seq_LN229_Human0.83129763
104* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82604999
105CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82078676
106FOXA1_25552417_ChIP-Seq_VCAP_Human0.81734734
107RBPJ_21746931_ChIP-Seq_IB4_Human0.81210779
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81086809
109SMC4_20622854_ChIP-Seq_HELA_Human0.80767226
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78642695
111FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.77782868
112HTT_18923047_ChIP-ChIP_STHdh_Human0.77515296
113STAT1_20625510_ChIP-Seq_HELA_Human0.77155726
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.76606128
115RARA_24833708_ChIP-Seq_LIVER_Mouse0.76394697
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75891933
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75891933
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.75548078
119FOXA1_25329375_ChIP-Seq_VCAP_Human0.74985369
120FOXA1_27270436_Chip-Seq_PROSTATE_Human0.74985369
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.74379862
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73719524
123* TP63_22573176_ChIP-Seq_HFKS_Human0.73668794
124P300_27268052_Chip-Seq_Bcells_Human0.73333341
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.72636690
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72593491
127BCAT_22108803_ChIP-Seq_LS180_Human0.72559692
128NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.71215962
129PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.69533752
130AHR_22903824_ChIP-Seq_MCF-7_Human0.69468601
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.69441628
132TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69431204
133STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69263918
134CDX2_22108803_ChIP-Seq_LS180_Human0.69230543
135FOXM1_26456572_ChIP-Seq_MCF-7_Human0.67856188
136CEBPB_22108803_ChIP-Seq_LS180_Human0.65791233
137* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65174241
138CJUN_26792858_Chip-Seq_BT549_Human0.64750536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH9.60895253
2MP0005360_urolithiasis6.52838099
3MP0002139_abnormal_hepatobiliary_system5.09855686
4MP0001666_abnormal_nutrient_absorption4.29354460
5MP0008875_abnormal_xenobiotic_pharmacok4.05349798
6MP0005085_abnormal_gallbladder_physiolo4.05322014
7MP0003806_abnormal_nucleotide_metabolis3.85457248
8MP0001873_stomach_inflammation3.66965407
9MP0005365_abnormal_bile_salt3.50905554
10MP0001664_abnormal_digestion3.24139616
11MP0010234_abnormal_vibrissa_follicle3.12890029
12MP0009840_abnormal_foam_cell3.01560737
13MP0010329_abnormal_lipoprotein_level2.72073425
14MP0003252_abnormal_bile_duct2.70120269
15MP0002876_abnormal_thyroid_physiology2.34861189
16MP0000470_abnormal_stomach_morphology2.20324814
17MP0004264_abnormal_extraembryonic_tissu2.19974279
18MP0002132_abnormal_respiratory_system2.07157972
19MP0004019_abnormal_vitamin_homeostasis1.88622205
20MP0001663_abnormal_digestive_system1.83562771
21MP0000462_abnormal_digestive_system1.72798015
22MP0005083_abnormal_biliary_tract1.71707993
23MP0005381_digestive/alimentary_phenotyp1.64599821
24MP0003705_abnormal_hypodermis_morpholog1.57770387
25MP0003191_abnormal_cellular_cholesterol1.52253177
26MP0005332_abnormal_amino_acid1.39849077
27MP0000609_abnormal_liver_physiology1.38202371
28MP0002118_abnormal_lipid_homeostasis1.37336222
29MP0000477_abnormal_intestine_morphology1.34969974
30MP0005408_hypopigmentation1.32157828
31MP0003868_abnormal_feces_composition1.26911447
32MP0002796_impaired_skin_barrier1.23338285
33MP0006054_spinal_hemorrhage1.20096505
34MP0001765_abnormal_ion_homeostasis1.16656567
35MP0009384_cardiac_valve_regurgitation1.14924742
36MP0000537_abnormal_urethra_morphology1.08873810
37MP0003186_abnormal_redox_activity1.06845585
38MP0003866_abnormal_defecation1.06805614
39MP0003011_delayed_dark_adaptation1.05780080
40MP0005319_abnormal_enzyme/_coenzyme1.05571943
41MP0005165_increased_susceptibility_to1.01841088
42MP0000490_abnormal_crypts_of1.01628915
43MP0010352_gastrointestinal_tract_polyps0.98840464
44MP0005636_abnormal_mineral_homeostasis0.98315794
45MP0005409_darkened_coat_color0.97254865
46MP0009643_abnormal_urine_homeostasis0.96932345
47MP0005395_other_phenotype0.96544795
48MP0003879_abnormal_hair_cell0.93105189
49MP0010155_abnormal_intestine_physiology0.92809825
50MP0002653_abnormal_ependyma_morphology0.89966276
51MP0002277_abnormal_respiratory_mucosa0.89955874
52MP0005584_abnormal_enzyme/coenzyme_acti0.88905087
53MP0000566_synostosis0.85862866
54MP0002168_other_aberrant_phenotype0.85656646
55MP0009053_abnormal_anal_canal0.84536666
56MP0009379_abnormal_foot_pigmentation0.83618800
57MP0005266_abnormal_metabolism0.82512110
58MP0004043_abnormal_pH_regulation0.82482938
59MP0003453_abnormal_keratinocyte_physiol0.82164148
60MP0001984_abnormal_olfaction0.79526555
61MP0001756_abnormal_urination0.76624567
62MP0010678_abnormal_skin_adnexa0.76036343
63MP0002254_reproductive_system_inflammat0.75527633
64MP0005670_abnormal_white_adipose0.74566756
65MP0003300_gastrointestinal_ulcer0.74197615
66MP0000598_abnormal_liver_morphology0.74047226
67MP0000678_abnormal_parathyroid_gland0.73384884
68MP0005451_abnormal_body_composition0.72838930
69MP0005084_abnormal_gallbladder_morpholo0.72694699
70MP0000639_abnormal_adrenal_gland0.72296082
71MP0003183_abnormal_peptide_metabolism0.71976427
72MP0005058_abnormal_lysosome_morphology0.71668346
73MP0009697_abnormal_copulation0.70740125
74MP0002822_catalepsy0.68695568
75MP0004947_skin_inflammation0.68448738
76MP0003656_abnormal_erythrocyte_physiolo0.65440126
77MP0000467_abnormal_esophagus_morphology0.65338657
78MP0004883_abnormal_blood_vessel0.64629093
79MP0009763_increased_sensitivity_to0.63857675
80MP0004133_heterotaxia0.63771473
81MP0005501_abnormal_skin_physiology0.63619494
82MP0005248_abnormal_Harderian_gland0.62032689
83MP0009642_abnormal_blood_homeostasis0.61227842
84MP0002138_abnormal_hepatobiliary_system0.61214913
85MP0005448_abnormal_energy_balance0.60855739
86MP0000538_abnormal_urinary_bladder0.58847844
87MP0008873_increased_physiological_sensi0.58835173
88MP0010368_abnormal_lymphatic_system0.58650309
89MP0005164_abnormal_response_to0.58510221
90MP0009780_abnormal_chondrocyte_physiolo0.58409533
91MP0005535_abnormal_body_temperature0.58364265
92MP0001216_abnormal_epidermal_layer0.57905566
93MP0000372_irregular_coat_pigmentation0.57568063
94MP0003718_maternal_effect0.56141317
95MP0001986_abnormal_taste_sensitivity0.55141432
96MP0005376_homeostasis/metabolism_phenot0.54960240
97MP0002078_abnormal_glucose_homeostasis0.54943475
98MP0002971_abnormal_brown_adipose0.53854699
99MP0003566_abnormal_cell_adhesion0.53090659
100MP0004147_increased_porphyrin_level0.52167859
101MP0002098_abnormal_vibrissa_morphology0.51863815
102MP0001764_abnormal_homeostasis0.51693937
103MP0005464_abnormal_platelet_physiology0.50042465
104MP0001661_extended_life_span0.49805885
105MP0000249_abnormal_blood_vessel0.49224533
106MP0005166_decreased_susceptibility_to0.48527099
107MP0003878_abnormal_ear_physiology0.48246250
108MP0005377_hearing/vestibular/ear_phenot0.48246250
109MP0006036_abnormal_mitochondrial_physio0.46284027
110MP0003950_abnormal_plasma_membrane0.45863176
111MP0003283_abnormal_digestive_organ0.45845597
112MP0000604_amyloidosis0.45636346
113MP0002136_abnormal_kidney_physiology0.44947925
114MP0005220_abnormal_exocrine_pancreas0.44895770
115MP0006082_CNS_inflammation0.44186607
116MP0003195_calcinosis0.43614447
117MP0002909_abnormal_adrenal_gland0.43512755
118MP0004782_abnormal_surfactant_physiolog0.43096555
119MP0001849_ear_inflammation0.42364247
120MP0003075_altered_response_to0.42266633
121MP0003953_abnormal_hormone_level0.42193101
122MP0000371_diluted_coat_color0.41835562
123MP0000377_abnormal_hair_follicle0.41558137
124MP0008469_abnormal_protein_level0.41339451
125MP0002877_abnormal_melanocyte_morpholog0.40969070
126MP0001845_abnormal_inflammatory_respons0.40867978
127MP0004185_abnormal_adipocyte_glucose0.40391030
128MP0005023_abnormal_wound_healing0.40165506
129MP0002060_abnormal_skin_morphology0.39823015
130MP0005334_abnormal_fat_pad0.39804068
131MP0008872_abnormal_physiological_respon0.39535538
132MP0002160_abnormal_reproductive_system0.38824369
133MP0002249_abnormal_larynx_morphology0.38606409
134MP0003119_abnormal_digestive_system0.37856918
135MP0009765_abnormal_xenobiotic_induced0.37598200
136MP0001243_abnormal_dermal_layer0.37472571
137MP0003638_abnormal_response/metabolism_0.37036590
138MP0002282_abnormal_trachea_morphology0.33968714
139MP0009764_decreased_sensitivity_to0.33568570

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.98129908
2Abnormal respiratory motile cilium morphology (HP:0005938)7.05929946
3Abnormal respiratory epithelium morphology (HP:0012253)7.05929946
4Abnormal respiratory motile cilium physiology (HP:0012261)6.92246915
5Hypobetalipoproteinemia (HP:0003563)6.79173640
6Rhinitis (HP:0012384)6.71785040
7Abnormal ciliary motility (HP:0012262)6.71369650
8Dynein arm defect of respiratory motile cilia (HP:0012255)6.69774663
9Absent/shortened dynein arms (HP:0200106)6.69774663
10Right ventricular cardiomyopathy (HP:0011663)6.08299779
11Intrahepatic cholestasis (HP:0001406)5.51226062
12Malnutrition (HP:0004395)5.38434151
13Abnormality of monocarboxylic acid metabolism (HP:0010996)5.31849530
14Chronic bronchitis (HP:0004469)5.03039738
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.90320904
16Abnormal gallbladder physiology (HP:0012438)4.82058278
17Cholecystitis (HP:0001082)4.82058278
18Xanthomatosis (HP:0000991)4.79790398
19Acanthocytosis (HP:0001927)4.78257758
20Bronchiectasis (HP:0002110)4.77155543
21Conjugated hyperbilirubinemia (HP:0002908)4.74621347
22Ileus (HP:0002595)4.69503757
23Hypolipoproteinemia (HP:0010981)4.53782218
24Nasal polyposis (HP:0100582)4.37868502
25Fat malabsorption (HP:0002630)4.27051517
26Deep venous thrombosis (HP:0002625)4.10493296
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.89342048
28Systemic lupus erythematosus (HP:0002725)3.75460021
29Abnormality of aromatic amino acid family metabolism (HP:0004338)3.69093992
30Abnormality of the nasal mucosa (HP:0000433)3.64391158
31Epidermoid cyst (HP:0200040)3.61572077
32Abnormality of purine metabolism (HP:0004352)3.59238291
33Male infertility (HP:0003251)3.56719715
34Hyperammonemia (HP:0001987)3.49232818
35Abnormality of vitamin metabolism (HP:0100508)3.30536189
36Hypercholesterolemia (HP:0003124)3.29561847
37Hyperglycinuria (HP:0003108)3.20371937
38Abnormality of sulfur amino acid metabolism (HP:0004339)3.19942130
39Infertility (HP:0000789)3.15341508
40Spontaneous abortion (HP:0005268)3.11859405
41Glomerulonephritis (HP:0000099)3.08019050
42Joint hemorrhage (HP:0005261)3.06031183
43Hyperactive renin-angiotensin system (HP:0000841)3.05383727
44Hyperbilirubinemia (HP:0002904)3.02179039
45Megaloblastic anemia (HP:0001889)3.00515335
46Prolonged partial thromboplastin time (HP:0003645)2.99221869
47Abnormality of nucleobase metabolism (HP:0010932)2.96624451
48Recurrent sinusitis (HP:0011108)2.95988400
49Pigmentary retinal degeneration (HP:0001146)2.95472634
50Abnormality of the vitamin B12 metabolism (HP:0004341)2.92864636
51Glycosuria (HP:0003076)2.88615595
52Abnormality of urine glucose concentration (HP:0011016)2.88615595
53Abdominal distention (HP:0003270)2.86162611
54Hypoglycemic coma (HP:0001325)2.85321063
55Increased purine levels (HP:0004368)2.84411804
56Hyperuricemia (HP:0002149)2.84411804
57Abnormality of vitamin B metabolism (HP:0004340)2.82333058
58Esophageal varix (HP:0002040)2.82331010
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.82037476
60Palpitations (HP:0001962)2.80423408
61Hypoalphalipoproteinemia (HP:0003233)2.79883397
62Bronchitis (HP:0012387)2.76160660
63Abnormality of serine family amino acid metabolism (HP:0010894)2.75936834
64Abnormality of glycine metabolism (HP:0010895)2.75936834
65Hydroxyprolinuria (HP:0003080)2.73232202
66Abnormality of proline metabolism (HP:0010907)2.73232202
67Proximal tubulopathy (HP:0000114)2.72199120
68Hyperlipoproteinemia (HP:0010980)2.70831829
69Abnormality of pyrimidine metabolism (HP:0004353)2.70069093
70Poikilocytosis (HP:0004447)2.65122986
71Gout (HP:0001997)2.63701849
72Complement deficiency (HP:0004431)2.56820932
73Late onset (HP:0003584)2.54749547
74Abnormal cartilage morphology (HP:0002763)2.54718160
75Recurrent otitis media (HP:0000403)2.54698496
76Metabolic acidosis (HP:0001942)2.54572847
77Cholelithiasis (HP:0001081)2.52747510
78Abnormal gallbladder morphology (HP:0012437)2.51344583
79Micronodular cirrhosis (HP:0001413)2.50378146
80Abnormality of the common coagulation pathway (HP:0010990)2.49658482
81Abnormal number of erythroid precursors (HP:0012131)2.49323687
82Rickets (HP:0002748)2.48992013
83Cupped ribs (HP:0000887)2.46427602
84Chronic sinusitis (HP:0011109)2.45750696
85Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.41960791
86Alkalosis (HP:0001948)2.38818165
87Ketosis (HP:0001946)2.36655607
88Hyperglycinemia (HP:0002154)2.35519963
89Skin nodule (HP:0200036)2.34582253
90Nausea (HP:0002018)2.34445257
91Decreased circulating renin level (HP:0003351)2.33972447
92Recurrent gram-negative bacterial infections (HP:0005420)2.32266213
93Woolly hair (HP:0002224)2.30283424
94Abnormality of fatty-acid metabolism (HP:0004359)2.29928516
95Vascular calcification (HP:0004934)2.29688561
96Renal salt wasting (HP:0000127)2.29631515
97Nephritis (HP:0000123)2.28934253
98Lethargy (HP:0001254)2.28589955
99Ketoacidosis (HP:0001993)2.22739343
100Hyperphosphaturia (HP:0003109)2.21621801
101Abnormality of cells of the erythroid lineage (HP:0012130)2.20191158
102Autoimmune thrombocytopenia (HP:0001973)2.19221962
103Syncope (HP:0001279)2.18567812
104Gingival bleeding (HP:0000225)2.17809968
105Hemorrhage of the eye (HP:0011885)2.16832024
106Abnormality of the intrinsic pathway (HP:0010989)2.14032851
107Polycythemia (HP:0001901)2.13511576
108Sensorimotor neuropathy (HP:0007141)2.12126831
109Chronic hepatic failure (HP:0100626)2.11280049
110Reticulocytosis (HP:0001923)2.10845216
111Osteomalacia (HP:0002749)2.10158167
112Hepatocellular carcinoma (HP:0001402)2.09008755
113Amyloidosis (HP:0011034)2.08360712
114Focal segmental glomerulosclerosis (HP:0000097)2.07991991
115Flat acetabular roof (HP:0003180)2.05288070
116Abnormality of the gallbladder (HP:0005264)2.04810681
117Glomerulosclerosis (HP:0000096)2.03478654
118Gastrointestinal dysmotility (HP:0002579)2.03304253
119Cardiovascular calcification (HP:0011915)2.02994364
120Increased mean platelet volume (HP:0011877)2.00133697
121Mitral stenosis (HP:0001718)1.98996842
122Abnormality of complement system (HP:0005339)1.98861629
123Abnormal biliary tract morphology (HP:0012440)1.98248843
124Steatorrhea (HP:0002570)1.98001575
125Hyperaldosteronism (HP:0000859)1.96185643
126Occipital encephalocele (HP:0002085)1.95315837
127Abnormality of the gastric mucosa (HP:0004295)1.94156906
128Goiter (HP:0000853)1.93924181
129Abnormal tarsal ossification (HP:0008369)1.92105945
130Chronic otitis media (HP:0000389)1.90509030
131Male pseudohermaphroditism (HP:0000037)1.88252305
132Abnormal urine phosphate concentration (HP:0012599)1.87718372
133Generalized aminoaciduria (HP:0002909)1.85105256
134Widely patent fontanelles and sutures (HP:0004492)1.83998235
135Dicarboxylic aciduria (HP:0003215)1.83177544
136Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83177544
137Pancreatitis (HP:0001733)1.81601826
138Abnormality of methionine metabolism (HP:0010901)1.81054215
139Spastic diplegia (HP:0001264)1.80648794
140Dehydration (HP:0001944)1.78343218
141Mesangial abnormality (HP:0001966)1.76509873
142Ventricular fibrillation (HP:0001663)1.76426983
143Abnormality of renin-angiotensin system (HP:0000847)1.73072061
144Hypotension (HP:0002615)1.71533891
145Bifid scrotum (HP:0000048)1.69061647
146Atelectasis (HP:0100750)1.63270268
147Hypophosphatemic rickets (HP:0004912)1.62635444
148Delayed CNS myelination (HP:0002188)1.60705326
149Purpura (HP:0000979)1.60086229
150Retinal atrophy (HP:0001105)1.58987607
151Hypophosphatemia (HP:0002148)1.55279577
152Joint swelling (HP:0001386)1.54479135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB47.36467057
2MAPK156.95992000
3MST1R6.58931637
4ACVR1B4.25582064
5MST43.97477676
6FRK3.81389657
7LMTK23.32738046
8EPHA22.74417491
9MET2.60858749
10MAP3K122.42632532
11PRKG22.34592601
12PKN22.11605055
13ERN12.04515087
14MAP2K21.99185548
15PTK61.84372950
16TRIB31.80818014
17MAP3K21.80269992
18MAPKAPK31.78121342
19LATS11.74254362
20RIPK11.74079093
21NUAK11.57268994
22GRK61.51781162
23STK241.46945645
24BMX1.40315403
25MAP3K31.30884957
26NME11.30035460
27EPHB21.27187698
28KSR21.27127963
29LRRK21.22725009
30OXSR11.20864817
31MAP2K11.17661594
32EPHA31.16664557
33TYK21.15134679
34BCKDK1.14858333
35TESK11.14523110
36MAP3K101.13861498
37FER1.11704402
38STK101.05037664
39FGFR31.04575363
40SMG11.03309944
41NEK60.99390661
42MAP3K110.98499677
43PTK20.97462324
44GRK10.96518573
45TAOK30.95859788
46NLK0.92506416
47PRKCI0.88809673
48MAP3K80.88721430
49AKT30.88168771
50DDR20.87051946
51MAP2K60.86988506
52PIM20.86767544
53ERBB20.83108157
54MAP3K90.82146099
55MYLK0.81903956
56NEK10.81662949
57EPHA40.81168970
58TAOK10.79719116
59MAPK110.78371868
60PAK30.72922625
61RPS6KB20.72569139
62PRKAA20.70501398
63NEK90.69151238
64FGFR40.67667139
65MAP3K10.66587270
66PRKCA0.66583337
67PDK30.63801531
68PDK40.63801531
69PRKCZ0.63373834
70EPHB10.62731414
71BCR0.62448078
72MAP3K70.62245054
73PIK3CG0.61910719
74PAK40.61519522
75STK160.61516109
76PBK0.61309136
77EEF2K0.60559414
78STK390.56571930
79STK380.56086604
80PRKACA0.56068436
81ARAF0.56026807
82WNK40.55999541
83TESK20.55938221
84PTK2B0.53985385
85STK30.51467850
86TBK10.50921037
87PRKCD0.49411517
88IRAK30.48723810
89GSK3A0.47504680
90CAMK2G0.45958858
91CDK60.45819581
92ICK0.43636367
93IGF1R0.43432805
94PDPK10.43321904
95SGK10.42037587
96WNK30.41747019
97PRKG10.41058891
98PDK20.39227566
99TRPM70.38274573
100ERBB30.38241497
101SCYL20.38191168
102DYRK1B0.37340501
103MATK0.37156859
104JAK10.36731544
105NME20.36352846
106PDGFRA0.36032984
107SIK10.36021754
108ABL20.34358180
109PRPF4B0.34160630
110CDC42BPA0.33225198
111PRKAA10.32592490
112PRKCE0.32503415
113FYN0.31804266
114MAP3K50.30570461
115LIMK10.30263648
116SRC0.30145998
117PAK20.30105567
118CSK0.29644499
119CAMK2B0.28931622
120TAOK20.28800962
121STK38L0.28311684
122PRKCB0.27918765
123TTK0.27732439
124PIK3CA0.27153364
125BMPR20.25739547
126CASK0.25691398
127CSNK1A10.24712465
128FLT30.24711393
129RIPK40.24438589
130PDGFRB0.23168522
131INSRR0.21913881
132RET0.21089015
133ROCK10.20451607
134CAMK2D0.20366059
135PDK10.19858942
136AKT20.19201285
137EGFR0.18861832
138PRKACG0.18772100
139MAP2K40.18447486
140PRKCQ0.18342256

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.88087475
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45943932
3Nitrogen metabolism_Homo sapiens_hsa009103.21085169
4* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.15445362
5* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.00325320
6Sulfur metabolism_Homo sapiens_hsa009202.92148361
7* Chemical carcinogenesis_Homo sapiens_hsa052042.54646144
8Vitamin digestion and absorption_Homo sapiens_hsa049772.52623497
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39751935
10Arginine biosynthesis_Homo sapiens_hsa002202.31668728
11Caffeine metabolism_Homo sapiens_hsa002322.30417093
12Starch and sucrose metabolism_Homo sapiens_hsa005002.18831632
13* Glutathione metabolism_Homo sapiens_hsa004802.12103239
14Mineral absorption_Homo sapiens_hsa049782.08184376
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.06879972
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.94840248
17Retinol metabolism_Homo sapiens_hsa008301.91642610
18Fatty acid degradation_Homo sapiens_hsa000711.88934612
19Folate biosynthesis_Homo sapiens_hsa007901.86614807
20Tryptophan metabolism_Homo sapiens_hsa003801.84932165
21Fructose and mannose metabolism_Homo sapiens_hsa000511.79418491
22Histidine metabolism_Homo sapiens_hsa003401.77582648
23Bile secretion_Homo sapiens_hsa049761.76978643
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.72879692
25Pentose phosphate pathway_Homo sapiens_hsa000301.69331127
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65731020
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64310848
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54968200
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.51287030
30Galactose metabolism_Homo sapiens_hsa000521.47179213
31PPAR signaling pathway_Homo sapiens_hsa033201.41781056
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40984549
33Carbon metabolism_Homo sapiens_hsa012001.40882882
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40142079
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30490371
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.26308041
37Biosynthesis of amino acids_Homo sapiens_hsa012301.26295432
38Pyruvate metabolism_Homo sapiens_hsa006201.22590763
39Selenocompound metabolism_Homo sapiens_hsa004501.21750545
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18686877
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18558137
42Renin-angiotensin system_Homo sapiens_hsa046141.14904369
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14564501
44Butanoate metabolism_Homo sapiens_hsa006501.13955742
45Gastric acid secretion_Homo sapiens_hsa049711.13875200
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10175623
47beta-Alanine metabolism_Homo sapiens_hsa004101.09828515
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.08152613
49Glycerolipid metabolism_Homo sapiens_hsa005611.06370574
50Fatty acid metabolism_Homo sapiens_hsa012121.04912591
51Tyrosine metabolism_Homo sapiens_hsa003501.01540904
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99344697
53Peroxisome_Homo sapiens_hsa041460.98119790
54Phenylalanine metabolism_Homo sapiens_hsa003600.96049579
55Propanoate metabolism_Homo sapiens_hsa006400.95682883
56Complement and coagulation cascades_Homo sapiens_hsa046100.95259626
57ABC transporters_Homo sapiens_hsa020100.94959345
58Steroid biosynthesis_Homo sapiens_hsa001000.93587337
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87410512
60Linoleic acid metabolism_Homo sapiens_hsa005910.86362585
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.84781865
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82732534
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82346239
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.81173425
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80526710
66Arginine and proline metabolism_Homo sapiens_hsa003300.70472336
67Collecting duct acid secretion_Homo sapiens_hsa049660.65176497
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63694598
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60744072
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58456452
71Fatty acid elongation_Homo sapiens_hsa000620.57827389
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.56220425
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55760063
74Sulfur relay system_Homo sapiens_hsa041220.52881593
75Protein digestion and absorption_Homo sapiens_hsa049740.45428532
76Metabolic pathways_Homo sapiens_hsa011000.39944303
77Ether lipid metabolism_Homo sapiens_hsa005650.39747166
78Tight junction_Homo sapiens_hsa045300.38582837
79Thyroid hormone synthesis_Homo sapiens_hsa049180.37639812
80Pancreatic secretion_Homo sapiens_hsa049720.36129134
81Fatty acid biosynthesis_Homo sapiens_hsa000610.34768762
82Other glycan degradation_Homo sapiens_hsa005110.34490503
83Prion diseases_Homo sapiens_hsa050200.31687830
84Staphylococcus aureus infection_Homo sapiens_hsa051500.30384457
85Arachidonic acid metabolism_Homo sapiens_hsa005900.29860727
86Lysine degradation_Homo sapiens_hsa003100.29109615
87Thyroid cancer_Homo sapiens_hsa052160.25599866
88Ovarian steroidogenesis_Homo sapiens_hsa049130.25523362
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25382805
90Sphingolipid metabolism_Homo sapiens_hsa006000.24327091
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18507517
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.17571205
93Bladder cancer_Homo sapiens_hsa052190.17497821
94Adherens junction_Homo sapiens_hsa045200.11491934
95Vitamin B6 metabolism_Homo sapiens_hsa007500.08580679
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.07952364
97Hepatitis C_Homo sapiens_hsa051600.07341415
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05967698
99Glucagon signaling pathway_Homo sapiens_hsa049220.05829053
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.03603221
101Insulin resistance_Homo sapiens_hsa049310.03356870
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.03135947
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.01406939
104Pertussis_Homo sapiens_hsa051330.01038313
105Serotonergic synapse_Homo sapiens_hsa047260.00380004
106Cocaine addiction_Homo sapiens_hsa05030-0.0730960
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0693853
108African trypanosomiasis_Homo sapiens_hsa05143-0.0466627
109Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0292919
110Bacterial invasion of epithelial cells_Homo sapiens_hsa05100-0.0114260
111Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0084703
112Huntingtons disease_Homo sapiens_hsa05016-0.0019929

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