GSTA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.96198773
2epithelial cilium movement (GO:0003351)9.29554453
3primary alcohol catabolic process (GO:0034310)8.61254258
4ethanol metabolic process (GO:0006067)7.86114170
5axoneme assembly (GO:0035082)6.99924148
6L-phenylalanine catabolic process (GO:0006559)6.87838925
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.87838925
8L-phenylalanine metabolic process (GO:0006558)6.78686680
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.78686680
10aromatic amino acid family catabolic process (GO:0009074)6.65758034
11tryptophan catabolic process (GO:0006569)6.41613054
12indole-containing compound catabolic process (GO:0042436)6.41613054
13indolalkylamine catabolic process (GO:0046218)6.41613054
14left/right pattern formation (GO:0060972)6.24808338
15lysine metabolic process (GO:0006553)6.12407227
16lysine catabolic process (GO:0006554)6.12407227
17vitamin transmembrane transport (GO:0035461)6.07245618
18kynurenine metabolic process (GO:0070189)6.06487437
19glyoxylate metabolic process (GO:0046487)6.03743933
20tryptophan metabolic process (GO:0006568)6.01709430
21diterpenoid biosynthetic process (GO:0016102)6.01393975
22epoxygenase P450 pathway (GO:0019373)5.61579842
23cysteine metabolic process (GO:0006534)5.52489960
24bile acid biosynthetic process (GO:0006699)5.39583472
25urate metabolic process (GO:0046415)5.28387762
26regulation of cilium movement (GO:0003352)5.21972155
27drug catabolic process (GO:0042737)5.12549561
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.12047428
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.11671280
30drug transmembrane transport (GO:0006855)5.10651091
31homocysteine metabolic process (GO:0050667)5.08714479
32serine family amino acid catabolic process (GO:0009071)5.08497069
33aromatic amino acid family metabolic process (GO:0009072)4.92615986
34urea cycle (GO:0000050)4.90039057
35urea metabolic process (GO:0019627)4.90039057
36sulfur amino acid catabolic process (GO:0000098)4.86811002
37retinoic acid metabolic process (GO:0042573)4.86506314
38high-density lipoprotein particle remodeling (GO:0034375)4.81407952
39regulation of cholesterol esterification (GO:0010872)4.81161967
40amino-acid betaine metabolic process (GO:0006577)4.78094377
41pyrimidine-containing compound transmembrane transport (GO:0072531)4.77355745
42negative regulation of cholesterol transport (GO:0032375)4.75459695
43negative regulation of sterol transport (GO:0032372)4.75459695
44left/right axis specification (GO:0070986)4.74432928
45short-chain fatty acid metabolic process (GO:0046459)4.70556201
46primary alcohol metabolic process (GO:0034308)4.64878167
47alpha-linolenic acid metabolic process (GO:0036109)4.63923095
48benzene-containing compound metabolic process (GO:0042537)4.62536872
49negative regulation of fibrinolysis (GO:0051918)4.60206172
50alpha-amino acid catabolic process (GO:1901606)4.55011588
51nitrogen cycle metabolic process (GO:0071941)4.53040093
52heme transport (GO:0015886)4.51376962
53indolalkylamine metabolic process (GO:0006586)4.50897618
54bile acid metabolic process (GO:0008206)4.49186966
55protein carboxylation (GO:0018214)4.43235630
56peptidyl-glutamic acid carboxylation (GO:0017187)4.43235630
57drug transport (GO:0015893)4.38145599
58progesterone metabolic process (GO:0042448)4.37090866
59exogenous drug catabolic process (GO:0042738)4.36061387
60aspartate family amino acid catabolic process (GO:0009068)4.35424808
61serine family amino acid metabolic process (GO:0009069)4.34417557
62amine catabolic process (GO:0009310)4.34257447
63cellular biogenic amine catabolic process (GO:0042402)4.34257447
64regulation of fibrinolysis (GO:0051917)4.31989764
65retinol metabolic process (GO:0042572)4.31079030
66phospholipid efflux (GO:0033700)4.30769760
67glutamate metabolic process (GO:0006536)4.26626907
68microtubule bundle formation (GO:0001578)4.26059510
69terpenoid biosynthetic process (GO:0016114)4.26011841
70cellular amino acid catabolic process (GO:0009063)4.25750877
71omega-hydroxylase P450 pathway (GO:0097267)4.25346247
72tyrosine metabolic process (GO:0006570)4.23085326
73cellular modified amino acid catabolic process (GO:0042219)4.20064234
74positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.17947256
75ventricular system development (GO:0021591)4.17674193
76regulation of protein activation cascade (GO:2000257)4.17527886
77cellular glucuronidation (GO:0052695)4.15530341
78cellular ketone body metabolic process (GO:0046950)4.11549214
79complement activation, alternative pathway (GO:0006957)4.09491228
80plasma lipoprotein particle remodeling (GO:0034369)4.08750231
81protein-lipid complex remodeling (GO:0034368)4.08750231
82macromolecular complex remodeling (GO:0034367)4.08750231
83regulation of triglyceride catabolic process (GO:0010896)4.07842053
84intraciliary transport (GO:0042073)4.04928830
85response to mercury ion (GO:0046689)4.04632287
86one-carbon compound transport (GO:0019755)4.03416197
872-oxoglutarate metabolic process (GO:0006103)4.02291493
88acetyl-CoA metabolic process (GO:0006084)4.02161240
89ethanol oxidation (GO:0006069)4.01772637
90negative regulation of humoral immune response (GO:0002921)4.01400828
91lung epithelium development (GO:0060428)4.00824153
92glycine metabolic process (GO:0006544)3.89963370
93glucuronate metabolic process (GO:0019585)3.87987775
94uronic acid metabolic process (GO:0006063)3.87987775
95regulation of complement activation (GO:0030449)3.87117422
96reverse cholesterol transport (GO:0043691)3.84896717
97serine family amino acid biosynthetic process (GO:0009070)3.84391662
98flavonoid metabolic process (GO:0009812)3.83729150
99aldehyde catabolic process (GO:0046185)3.83385299
100plasma lipoprotein particle clearance (GO:0034381)3.83237839
101cilium organization (GO:0044782)3.82618565
102negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.80747812
103negative regulation of B cell mediated immunity (GO:0002713)3.80703193
104negative regulation of immunoglobulin mediated immune response (GO:0002890)3.80703193
105dicarboxylic acid biosynthetic process (GO:0043650)3.80109623
106response to nitrosative stress (GO:0051409)3.80041098
107establishment of apical/basal cell polarity (GO:0035089)3.78696371
108carboxylic acid catabolic process (GO:0046395)3.78237533
109organic acid catabolic process (GO:0016054)3.78237533
110sperm capacitation (GO:0048240)3.77709341
111L-ascorbic acid metabolic process (GO:0019852)3.77329260
112xenobiotic catabolic process (GO:0042178)3.76642096
113fatty acid oxidation (GO:0019395)3.76312271
114response to xenobiotic stimulus (GO:0009410)3.75753556
115very-low-density lipoprotein particle assembly (GO:0034379)3.73972680
116fatty acid beta-oxidation (GO:0006635)3.72434132
117drug metabolic process (GO:0017144)3.72022684
118carnitine metabolic process (GO:0009437)3.70667297
119coenzyme catabolic process (GO:0009109)3.70613854
120cilium assembly (GO:0042384)3.70325299
121acylglycerol homeostasis (GO:0055090)3.69810499
122triglyceride homeostasis (GO:0070328)3.69810499
123phosphate ion transport (GO:0006817)3.69106139
124lipid oxidation (GO:0034440)3.68810339
125protein-lipid complex assembly (GO:0065005)3.68786781
126valine metabolic process (GO:0006573)3.68179302
127ketone body metabolic process (GO:1902224)3.62437025
128negative regulation of lipase activity (GO:0060192)3.61952341
129plasma lipoprotein particle assembly (GO:0034377)3.60881323
130tolerance induction (GO:0002507)3.58962675
131cholesterol efflux (GO:0033344)3.58483609
132arginine metabolic process (GO:0006525)3.56679234
133phosphate ion transmembrane transport (GO:0035435)3.55331143
134monocarboxylic acid catabolic process (GO:0072329)3.55123385
135bile acid and bile salt transport (GO:0015721)3.53175126
136fibrinolysis (GO:0042730)3.49848598
137C21-steroid hormone metabolic process (GO:0008207)3.45458291
138intestinal cholesterol absorption (GO:0030299)3.45136151
139polyketide metabolic process (GO:0030638)3.43545981
140doxorubicin metabolic process (GO:0044598)3.43545981
141daunorubicin metabolic process (GO:0044597)3.43545981
142negative regulation of T cell differentiation in thymus (GO:0033085)3.35338960
143regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.26059029
144hydrogen peroxide biosynthetic process (GO:0050665)3.24945474
145glomerular epithelial cell development (GO:0072310)3.22898674
146phosphatidylcholine biosynthetic process (GO:0006656)3.20327211
147establishment of monopolar cell polarity (GO:0061162)3.17627879
148establishment or maintenance of monopolar cell polarity (GO:0061339)3.17627879
149phenylpropanoid metabolic process (GO:0009698)3.16959309
150cellular aldehyde metabolic process (GO:0006081)3.16947918
151protein localization to cilium (GO:0061512)3.16313492
152centriole assembly (GO:0098534)3.16292385
153aminoglycoside antibiotic metabolic process (GO:0030647)3.16073782
154retinal metabolic process (GO:0042574)3.09671619
155hydrogen peroxide catabolic process (GO:0042744)3.09572930
156sodium ion homeostasis (GO:0055078)3.05815673
157regulation of interleukin-5 production (GO:0032674)3.04127375
158regulation of microtubule-based movement (GO:0060632)2.99844934
159* xenobiotic metabolic process (GO:0006805)2.98334859
160axonemal dynein complex assembly (GO:0070286)15.2591843
161cilium or flagellum-dependent cell motility (GO:0001539)12.5404828
162cilium movement (GO:0003341)10.7454902
163motile cilium assembly (GO:0044458)10.1370925

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.79468058
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.74676859
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.30298358
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.07569164
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.40286361
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.71954268
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.52756766
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.83077078
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.64038193
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.30651355
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.29811835
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29291729
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.18429134
14* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.16559932
15DROSHA_22980978_ChIP-Seq_HELA_Human2.14923369
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03248509
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.9439583
18CLOCK_20551151_ChIP-Seq_293T_Human1.93730659
19FOXA2_19822575_ChIP-Seq_HepG2_Human1.57945018
20AHR_22903824_ChIP-Seq_MCF-7_Human1.55176301
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49077286
22TP63_23658742_ChIP-Seq_EP156T_Human1.46321271
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44785343
24* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44532285
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.44383999
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.42744418
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42516563
28FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37054751
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.36327367
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31508006
31PHF8_20622853_ChIP-Seq_HELA_Human1.31421074
32CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30521744
33HNFA_21074721_ChIP-Seq_CACO-2_Human1.29987996
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.29733796
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.29514472
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29511997
37ETV1_20927104_ChIP-Seq_GIST48_Human1.29330081
38SMC4_20622854_ChIP-Seq_HELA_Human1.27301850
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25751094
40ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21434214
41PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.20837956
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.20757653
43STAT1_20625510_ChIP-Seq_HELA_Human1.18893090
44TP53_18474530_ChIP-ChIP_U2OS_Human1.18122582
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17103495
46KLF5_25053715_ChIP-Seq_YYC3_Human1.16950474
47GATA4_25053715_ChIP-Seq_YYC3_Human1.16072005
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15523503
49CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15019112
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.12742356
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11839693
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11753872
53TP63_22573176_ChIP-Seq_HFKS_Human1.11564736
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10985444
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10663267
56FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.09160957
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09123896
58RBPJ_21746931_ChIP-Seq_IB4_Human1.08737465
59CBX2_22325352_ChIP-Seq_293T-Rex_Human1.08445306
60SMAD3_21741376_ChIP-Seq_HESCs_Human1.08212180
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06733083
62NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06630686
63GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06083732
64HTT_18923047_ChIP-ChIP_STHdh_Human1.04638333
65GATA6_21074721_ChIP-Seq_CACO-2_Human1.04429218
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.03603031
67GATA1_19941826_ChIP-Seq_K562_Human1.03068277
68NFYA_21822215_ChIP-Seq_K562_Human1.02803335
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02666252
70CTCF_27219007_Chip-Seq_Bcells_Human1.02110798
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00890410
72CDX2_20551321_ChIP-Seq_CACO-2_Human0.99721803
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99311767
74GATA1_22025678_ChIP-Seq_K562_Human0.98651313
75RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97973655
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97207698
77ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96745646
78TP53_16413492_ChIP-PET_HCT116_Human0.96445919
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90977778
80SMRT_27268052_Chip-Seq_Bcells_Human0.89385065
81IRF8_22096565_ChIP-ChIP_GC-B_Human0.89373022
82* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88386953
83VDR_22108803_ChIP-Seq_LS180_Human0.87329877
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86943455
85NFYB_21822215_ChIP-Seq_K562_Human0.86929207
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86519520
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.85855771
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85450497
89FOXO3_23340844_ChIP-Seq_DLD1_Human0.85008828
90SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84868171
91CTCF_20526341_ChIP-Seq_ESCs_Human0.83657153
92PHF8_20622854_ChIP-Seq_HELA_Human0.83424160
93BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83358410
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82601820
95SOX2_21211035_ChIP-Seq_LN229_Human0.81907433
96ZNF263_19887448_ChIP-Seq_K562_Human0.80947088
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78784420
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77653876
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77653876
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76578220
101EGR1_19032775_ChIP-ChIP_M12_Human0.74428721
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74086369
103LXR_22292898_ChIP-Seq_THP-1_Human0.73342095
104* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72872742
105GATA6_25053715_ChIP-Seq_YYC3_Human0.72798507
106RAD21_21589869_ChIP-Seq_MESCs_Mouse0.71067694
107SOX2_20726797_ChIP-Seq_SW620_Human0.69952312
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69348442
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69210766
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.67234281
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.66191781
112CEBPB_22108803_ChIP-Seq_LS180_Human0.65888866
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.65828526
114AR_20517297_ChIP-Seq_VCAP_Human0.61300640
115BCAT_22108803_ChIP-Seq_LS180_Human0.61231938
116FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60786705
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58175384
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57700851
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.57033882
120* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56867526
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.56678037
122MYC_19915707_ChIP-ChIP_AK7_Human0.54367717
123AR_21909140_ChIP-Seq_LNCAP_Human0.53075369
124RACK7_27058665_Chip-Seq_MCF-7_Human0.52720290
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.51379955
126* CDX2_22108803_ChIP-Seq_LS180_Human0.50724757
127FOXA1_25552417_ChIP-Seq_VCAP_Human0.50191770
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.50124833
129ESET_19884257_ChIP-Seq_ESCs_Mouse0.49786107
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.49343097
131GATA3_24758297_ChIP-Seq_MCF-7_Human0.49226731
132P63_26484246_Chip-Seq_KERATINOCYTES_Human0.48636131
133TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.48344298
134CBP_21632823_ChIP-Seq_H3396_Human0.48012831
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.47679340
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.47439861
137P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.47102345
138ERG_21242973_ChIP-ChIP_JURKAT_Human0.45721715
139CSB_26484114_Chip-Seq_FIBROBLAST_Human0.45716570
140GATA2_19941826_ChIP-Seq_K562_Human0.45713127
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.44312151
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.43779043
143TBX20_22328084_ChIP-Seq_HEART_Mouse0.43779043
144* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43641483
145STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.42787760
146RARB_24833708_ChIP-Seq_LIVER_Mouse0.42764863
147EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.42718285
148* STAT1_17558387_ChIP-Seq_HELA_Human0.42542076
149PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42539099
150SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.42253581
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42252353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.07403859
2MP0002139_abnormal_hepatobiliary_system8.00220392
3MP0005365_abnormal_bile_salt5.93503425
4MP0005085_abnormal_gallbladder_physiolo5.56774215
5MP0008875_abnormal_xenobiotic_pharmacok4.87589112
6MP0002132_abnormal_respiratory_system4.31425280
7MP0003195_calcinosis3.82920611
8MP0003806_abnormal_nucleotide_metabolis3.61185123
9MP0005332_abnormal_amino_acid3.59402847
10MP0003252_abnormal_bile_duct3.58028191
11MP0004019_abnormal_vitamin_homeostasis3.19340539
12MP0002653_abnormal_ependyma_morphology3.17551493
13MP0010329_abnormal_lipoprotein_level2.91816257
14MP0009780_abnormal_chondrocyte_physiolo2.81408791
15MP0002138_abnormal_hepatobiliary_system2.59775743
16MP0009840_abnormal_foam_cell2.54112946
17MP0001984_abnormal_olfaction2.43191074
18MP0002277_abnormal_respiratory_mucosa2.40655336
19MP0001666_abnormal_nutrient_absorption2.31957850
20MP0009643_abnormal_urine_homeostasis2.28548614
21MP0004133_heterotaxia2.25015785
22MP0004043_abnormal_pH_regulation2.24978025
23MP0005083_abnormal_biliary_tract2.14928543
24MP0003191_abnormal_cellular_cholesterol1.98709093
25MP0005636_abnormal_mineral_homeostasis1.93223006
26MP0002118_abnormal_lipid_homeostasis1.85581270
27MP0000609_abnormal_liver_physiology1.81173783
28MP0005319_abnormal_enzyme/_coenzyme1.74738829
29MP0000566_synostosis1.67289439
30MP0001764_abnormal_homeostasis1.64973627
31MP0005584_abnormal_enzyme/coenzyme_acti1.57775798
32MP0001756_abnormal_urination1.56855238
33MP0008789_abnormal_olfactory_epithelium1.54354142
34MP0003186_abnormal_redox_activity1.52847488
35MP0005451_abnormal_body_composition1.48750279
36MP0005623_abnormal_meninges_morphology1.45751964
37MP0002136_abnormal_kidney_physiology1.38468989
38MP0001765_abnormal_ion_homeostasis1.38375858
39MP0002909_abnormal_adrenal_gland1.29919427
40MP0010155_abnormal_intestine_physiology1.20573586
41MP0003868_abnormal_feces_composition1.19594477
42MP0002282_abnormal_trachea_morphology1.19279052
43MP0000383_abnormal_hair_follicle1.18173303
44MP0001986_abnormal_taste_sensitivity1.17737511
45MP0010678_abnormal_skin_adnexa1.14833061
46MP0009697_abnormal_copulation1.10570860
47MP0002254_reproductive_system_inflammat1.08219738
48MP0009764_decreased_sensitivity_to1.08005680
49MP0004883_abnormal_blood_vessel1.05312231
50MP0000678_abnormal_parathyroid_gland1.03863855
51MP0003011_delayed_dark_adaptation1.02384104
52MP0005084_abnormal_gallbladder_morpholo1.00896813
53MP0005164_abnormal_response_to0.98413190
54MP0000598_abnormal_liver_morphology0.95953856
55MP0006036_abnormal_mitochondrial_physio0.95254823
56MP0005408_hypopigmentation0.95065491
57MP0005647_abnormal_sex_gland0.94104525
58MP0002796_impaired_skin_barrier0.93101737
59MP0002160_abnormal_reproductive_system0.93042190
60MP0009642_abnormal_blood_homeostasis0.90391976
61MP0005670_abnormal_white_adipose0.89167808
62MP0002876_abnormal_thyroid_physiology0.88504430
63MP0000604_amyloidosis0.86110495
64MP0005499_abnormal_olfactory_system0.86027476
65MP0005394_taste/olfaction_phenotype0.86027476
66MP0008469_abnormal_protein_level0.85789224
67MP0009763_increased_sensitivity_to0.76453871
68MP0005535_abnormal_body_temperature0.73647148
69MP0003941_abnormal_skin_development0.73613619
70MP0003705_abnormal_hypodermis_morpholog0.71939240
71MP0005409_darkened_coat_color0.71887390
72MP0002249_abnormal_larynx_morphology0.71216721
73MP0009053_abnormal_anal_canal0.71198472
74MP0000538_abnormal_urinary_bladder0.70048578
75MP0003329_amyloid_beta_deposits0.69515814
76MP0005376_homeostasis/metabolism_phenot0.68552196
77MP0010234_abnormal_vibrissa_follicle0.68244457
78MP0005220_abnormal_exocrine_pancreas0.67551587
79MP0006082_CNS_inflammation0.66452631
80MP0005023_abnormal_wound_healing0.65942873
81MP0002078_abnormal_glucose_homeostasis0.65290715
82MP0005248_abnormal_Harderian_gland0.65135848
83MP0009379_abnormal_foot_pigmentation0.64821820
84MP0000681_abnormal_thyroid_gland0.64392521
85MP0002168_other_aberrant_phenotype0.64074817
86MP0009765_abnormal_xenobiotic_induced0.63873290
87MP0003656_abnormal_erythrocyte_physiolo0.62942978
88MP0001664_abnormal_digestion0.61911875
89MP0003638_abnormal_response/metabolism_0.61841712
90MP0002928_abnormal_bile_duct0.60971404
91MP0000230_abnormal_systemic_arterial0.60722123
92MP0008961_abnormal_basal_metabolism0.59077267
93MP0002971_abnormal_brown_adipose0.58762041
94MP0001346_abnormal_lacrimal_gland0.58017865
95MP0002638_abnormal_pupillary_reflex0.56578496
96MP0005395_other_phenotype0.56373815
97MP0001661_extended_life_span0.56371172
98MP0000467_abnormal_esophagus_morphology0.56236583
99MP0002135_abnormal_kidney_morphology0.55924697
100MP0005058_abnormal_lysosome_morphology0.55230409
101MP0010030_abnormal_orbit_morphology0.53232319
102MP0003690_abnormal_glial_cell0.53209646
103MP0005666_abnormal_adipose_tissue0.52988379
104MP0003303_peritoneal_inflammation0.52912428
105MP0002233_abnormal_nose_morphology0.52753573
106MP0001944_abnormal_pancreas_morphology0.52624699
107MP0001270_distended_abdomen0.52182689
108MP0002734_abnormal_mechanical_nocicepti0.50933849
109MP0000858_altered_metastatic_potential0.50886887
110MP0005334_abnormal_fat_pad0.48772156
111MP0010368_abnormal_lymphatic_system0.46564920
112MP0005266_abnormal_metabolism0.46189148
113MP0004264_abnormal_extraembryonic_tissu0.45666510
114MP0003879_abnormal_hair_cell0.45544562
115MP0003950_abnormal_plasma_membrane0.45227511
116MP0001663_abnormal_digestive_system0.43364577
117MP0005501_abnormal_skin_physiology0.43044672
118MP0003878_abnormal_ear_physiology0.41977202
119MP0005377_hearing/vestibular/ear_phenot0.41977202
120MP0003953_abnormal_hormone_level0.41076542
121MP0008874_decreased_physiological_sensi0.40847835
122MP0006035_abnormal_mitochondrial_morpho0.40546975
123MP0004782_abnormal_surfactant_physiolog0.39531198
124MP0003075_altered_response_to0.39520545
125MP0003300_gastrointestinal_ulcer0.38657145
126MP0004885_abnormal_endolymph0.37498625
127MP0005166_decreased_susceptibility_to0.36808016
128MP0004130_abnormal_muscle_cell0.36465213
129MP0008873_increased_physiological_sensi0.36326093
130MP0008872_abnormal_physiological_respon0.35502555
131MP0002098_abnormal_vibrissa_morphology0.35468308
132MP0003724_increased_susceptibility_to0.33594657
133MP0003959_abnormal_lean_body0.33527093
134MP0004381_abnormal_hair_follicle0.29629320
135MP0005464_abnormal_platelet_physiology0.29279066
136MP0005165_increased_susceptibility_to0.28337044
137MP0001958_emphysema0.28083186
138MP0000639_abnormal_adrenal_gland0.27685227
139MP0001845_abnormal_inflammatory_respons0.26827865
140MP0003718_maternal_effect0.26665037
141MP0009115_abnormal_fat_cell0.25461495
142MP0001216_abnormal_epidermal_layer0.25256262
143MP0009672_abnormal_birth_weight0.25252187

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.93193198
2Rhinitis (HP:0012384)9.74334392
3Chronic bronchitis (HP:0004469)7.56926002
4Bronchiectasis (HP:0002110)7.02701174
5Nasal polyposis (HP:0100582)6.15999874
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.94811615
7Intrahepatic cholestasis (HP:0001406)5.59675237
8Abnormality of monocarboxylic acid metabolism (HP:0010996)5.59385954
9Deep venous thrombosis (HP:0002625)5.36649557
10Xanthomatosis (HP:0000991)5.20378919
11Abnormality of glutamine family amino acid metabolism (HP:0010902)5.13865075
12Abnormality of the nasal mucosa (HP:0000433)5.08844248
13Hyperglycinuria (HP:0003108)5.03821457
14Gout (HP:0001997)4.83293717
15Hypobetalipoproteinemia (HP:0003563)4.64445531
16Prolonged partial thromboplastin time (HP:0003645)4.59929892
17Abnormality of glycine metabolism (HP:0010895)4.52621164
18Abnormality of serine family amino acid metabolism (HP:0010894)4.52621164
19Ketosis (HP:0001946)4.40580113
20Hyperammonemia (HP:0001987)4.35826466
21Hyperglycinemia (HP:0002154)4.30225520
22Male infertility (HP:0003251)4.13406450
23Recurrent sinusitis (HP:0011108)4.11536983
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10835250
25Infertility (HP:0000789)4.07207468
26Bronchitis (HP:0012387)4.05289184
27Abnormality of purine metabolism (HP:0004352)4.03124860
28Hypokalemic alkalosis (HP:0001949)3.98776325
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.93760937
30Ketoacidosis (HP:0001993)3.91353075
31Increased circulating renin level (HP:0000848)3.87742826
32Alkalosis (HP:0001948)3.84160184
33Complement deficiency (HP:0004431)3.83290690
34Abnormality of nucleobase metabolism (HP:0010932)3.79245070
35Hypoglycemic coma (HP:0001325)3.73616068
36Hyperactive renin-angiotensin system (HP:0000841)3.70409527
37Hyperlipoproteinemia (HP:0010980)3.69864893
38Chronic sinusitis (HP:0011109)3.68538053
39Abnormality of fatty-acid metabolism (HP:0004359)3.67190645
40Joint hemorrhage (HP:0005261)3.64265058
41Metabolic alkalosis (HP:0200114)3.62402414
42Hyperuricemia (HP:0002149)3.59714687
43Increased purine levels (HP:0004368)3.59714687
44Recurrent otitis media (HP:0000403)3.56849928
45Proximal tubulopathy (HP:0000114)3.54424026
46Fat malabsorption (HP:0002630)3.41098844
47Hypolipoproteinemia (HP:0010981)3.40958188
48Abnormal urine output (HP:0012590)3.39319048
49Polyuria (HP:0000103)3.35722042
50Abnormality of pyrimidine metabolism (HP:0004353)3.31485491
51Occipital encephalocele (HP:0002085)3.27638394
52Abnormality of the common coagulation pathway (HP:0010990)3.24386637
53Epidermoid cyst (HP:0200040)3.24055865
54Abnormality of methionine metabolism (HP:0010901)3.17660383
55Chronic hepatic failure (HP:0100626)3.15780068
56Hypomagnesemia (HP:0002917)3.14983147
57Generalized aminoaciduria (HP:0002909)3.13292813
58Delayed CNS myelination (HP:0002188)3.08883481
59Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.08280169
60Abnormality of chloride homeostasis (HP:0011422)3.06784420
61Abnormality of renal excretion (HP:0011036)3.05401635
62Vascular calcification (HP:0004934)3.04139564
63Metabolic acidosis (HP:0001942)2.90406532
64Conjugated hyperbilirubinemia (HP:0002908)2.90071032
65Hypoalphalipoproteinemia (HP:0003233)2.87074299
66Lethargy (HP:0001254)2.84903883
67Chronic otitis media (HP:0000389)2.83494197
68Abnormality of serum amino acid levels (HP:0003112)2.83022714
69Glycosuria (HP:0003076)2.78746072
70Abnormality of urine glucose concentration (HP:0011016)2.78746072
71Pancreatic fibrosis (HP:0100732)2.77395294
72Hydroxyprolinuria (HP:0003080)2.75279165
73Abnormality of proline metabolism (HP:0010907)2.75279165
74Dicarboxylic aciduria (HP:0003215)2.74884543
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.74884543
76Abnormality of complement system (HP:0005339)2.74728093
77Hyperbilirubinemia (HP:0002904)2.73803465
78True hermaphroditism (HP:0010459)2.73789263
79Cardiovascular calcification (HP:0011915)2.70047833
80Malnutrition (HP:0004395)2.68326142
81Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.67870063
82Hypercholesterolemia (HP:0003124)2.67137405
83Steatorrhea (HP:0002570)2.64662206
84Atelectasis (HP:0100750)2.60670842
85Rickets (HP:0002748)2.58951037
86Abnormality of the intrinsic pathway (HP:0010989)2.58703629
87Abnormality of magnesium homeostasis (HP:0004921)2.57898032
88Hepatocellular carcinoma (HP:0001402)2.57356432
89Vomiting (HP:0002013)2.54216572
90Late onset (HP:0003584)2.50331494
91Irritability (HP:0000737)2.48029670
92Polydipsia (HP:0001959)2.45424724
93Abnormal drinking behavior (HP:0030082)2.45424724
94Cystic liver disease (HP:0006706)2.43578422
95Neonatal onset (HP:0003623)2.43453276
96Renal salt wasting (HP:0000127)2.41055032
97Spastic diplegia (HP:0001264)2.40485853
98Cerebral edema (HP:0002181)2.39805694
99Abnormality of renin-angiotensin system (HP:0000847)2.36489390
100Hypoglycemic seizures (HP:0002173)2.31390750
101Hyperaldosteronism (HP:0000859)2.28592312
102Enlarged kidneys (HP:0000105)2.27756269
103Renal tubular acidosis (HP:0001947)2.27346423
104Pancreatic cysts (HP:0001737)2.26355625
105Tetany (HP:0001281)2.24477614
106Nephrolithiasis (HP:0000787)2.24082529
107Molar tooth sign on MRI (HP:0002419)2.23741846
108Abnormality of midbrain morphology (HP:0002418)2.23741846
109Hyperphosphaturia (HP:0003109)2.17905735
110Mitral stenosis (HP:0001718)2.16691260
111Spontaneous abortion (HP:0005268)2.13155406
112Abnormal enzyme/coenzyme activity (HP:0012379)2.12896272
113Myocardial infarction (HP:0001658)2.08303901
114Systemic lupus erythematosus (HP:0002725)2.05985153
115Nephronophthisis (HP:0000090)2.02741094
116Abnormality of transition element cation homeostasis (HP:0011030)2.02589386
117Confusion (HP:0001289)2.01712788
118Abnormality of iron homeostasis (HP:0011031)2.00518913
119Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.5668430
120Abnormal respiratory motile cilium morphology (HP:0005938)10.5105502
121Abnormal respiratory epithelium morphology (HP:0012253)10.5105502
122Abnormal respiratory motile cilium physiology (HP:0012261)10.2212505
123Dynein arm defect of respiratory motile cilia (HP:0012255)10.1044183
124Absent/shortened dynein arms (HP:0200106)10.1044183
125Hypophosphatemic rickets (HP:0004912)1.98546159
126Decreased circulating renin level (HP:0003351)1.98284592
127Pancreatitis (HP:0001733)1.97227923
128Nausea (HP:0002018)1.94320112
129Postaxial foot polydactyly (HP:0001830)1.94030955
130Sensorimotor neuropathy (HP:0007141)1.93696305
131Abnormality of alkaline phosphatase activity (HP:0004379)1.93134896
132Tubulointerstitial nephritis (HP:0001970)1.88056483
133Male pseudohermaphroditism (HP:0000037)1.80431957
134Bell-shaped thorax (HP:0001591)1.80124065
135Nephropathy (HP:0000112)1.73771989
136Hyperkalemia (HP:0002153)1.71858039
137Amyloidosis (HP:0011034)1.65859076
138Congenital hepatic fibrosis (HP:0002612)1.65805727
139Recurrent bronchitis (HP:0002837)1.63538871
140Abnormality of the renal medulla (HP:0100957)1.61331518
141Absent frontal sinuses (HP:0002688)1.54918255
142Abnormality of vitamin metabolism (HP:0100508)1.47969813
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.45742968
144Anencephaly (HP:0002323)1.44002691
145Bifid scrotum (HP:0000048)1.43840059
146Oculomotor apraxia (HP:0000657)1.42822832
147Aplasia/Hypoplasia of the spleen (HP:0010451)1.41108668
148Asplenia (HP:0001746)1.38494716
149Medial flaring of the eyebrow (HP:0010747)1.37725763
150Tubular atrophy (HP:0000092)1.34626616
151Furrowed tongue (HP:0000221)1.34623330
152Glucose intolerance (HP:0000833)1.33461064
153Gingival bleeding (HP:0000225)1.30978797
154Hyponatremia (HP:0002902)1.30866683
155Congenital primary aphakia (HP:0007707)1.29957497
156Short thorax (HP:0010306)1.26363689
157Osteomalacia (HP:0002749)1.25346978
158Flat acetabular roof (HP:0003180)1.24832388
159Glomerulonephritis (HP:0000099)1.24408026
160Gait imbalance (HP:0002141)1.24204340
161Decreased central vision (HP:0007663)1.23346124
162Stage 5 chronic kidney disease (HP:0003774)1.21786525
163Postaxial hand polydactyly (HP:0001162)1.21644599
164Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.20837010
165Abnormality of the distal phalanges of the toes (HP:0010182)1.17746650
166Recurrent gram-negative bacterial infections (HP:0005420)1.16134935
167Hypotension (HP:0002615)1.15932361
168Sclerocornea (HP:0000647)1.15534339
169Nephrogenic diabetes insipidus (HP:0009806)1.15231855

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.85893062
2BCKDK5.58920777
3WNK35.31057105
4OXSR15.11142043
5FGFR43.27609819
6MST1R3.06512081
7STK392.88746894
8ERN12.78681027
9SIK12.50438224
10ERBB42.35884060
11PBK2.22560225
12NME11.95819934
13TAOK31.94907809
14MAP3K121.87729201
15STK241.80941439
16INSRR1.77782578
17STK38L1.77679958
18DAPK21.77341505
19PIK3CG1.77008696
20ACVR1B1.76228050
21SMG11.75566926
22LMTK21.69045981
23TTK1.65069490
24NEK61.47359253
25MAP3K31.36446484
26SGK2231.34273478
27SGK4941.34273478
28PDK31.30461011
29PDK41.30461011
30PTK61.28677473
31TRIB31.24432895
32BCR1.23881097
33MAPK111.23772463
34LATS11.18450179
35EPHB11.17975403
36EEF2K1.17332317
37MAP2K41.13610617
38PTK2B1.10982770
39ABL21.10468104
40FRK1.08459561
41PKN21.07414843
42MET1.07309161
43TESK11.07235334
44NEK11.00937318
45MAP3K70.96525120
46PDK20.91049084
47DYRK1B0.89101207
48TYK20.87985351
49GRK60.87772786
50MAP3K140.87192908
51PINK10.84840967
52SGK30.82523749
53PRKAA20.81960677
54TIE10.80629183
55GSK3A0.79886231
56PRKCI0.79381785
57JAK20.78261496
58SGK20.77852359
59MST40.75799296
60MAPK150.74504207
61RIPK10.74028631
62RIPK40.73833977
63NLK0.72340692
64MAP3K110.72087739
65TRPM70.71803795
66STK160.71630730
67MYLK0.70518990
68PTK20.70406885
69FLT30.70194443
70EPHA30.68297722
71NEK90.67241897
72LRRK20.66486427
73TGFBR20.65921197
74PRKCZ0.65169483
75ICK0.63260326
76FER0.62149842
77MUSK0.60224658
78FGFR20.58858708
79PRKACG0.58177676
80ERBB20.58002460
81PNCK0.57417386
82KDR0.56283379
83PRKAA10.56278888
84TBK10.54898823
85PDPK10.53892943
86STK380.53212112
87TESK20.51706629
88WNK10.51252540
89ERBB30.50965456
90MAPK120.49244955
91MAP2K30.48597536
92PRKCD0.48366085
93MAP2K10.48209511
94MAPK40.47726087
95TLK10.47542172
96MARK20.46203795
97PAK30.46008900
98CAMK2G0.45448353
99BRSK20.45028180
100PIK3CA0.44423222
101JAK10.43421379
102EPHA20.42929721
103MAP2K60.42216267
104CDK60.41195503
105EPHA40.39115990
106MAP3K20.38976909
107PAK40.36730346
108PDK10.34802287
109IGF1R0.33249098
110CAMKK10.33237807
111PRKG20.32574040
112CSK0.31825332
113AKT20.30444730
114BMX0.28488802
115PRKCQ0.28194664
116PRKCA0.27567862
117CAMK1D0.27467859
118NME20.27331164
119MATK0.27155099
120MAP3K100.25110026
121STK100.23995227
122MTOR0.23792371
123SRC0.23401478
124ROCK10.23369030
125IRAK30.23011436
126ROCK20.21797472
127PRKCE0.21226482
128EGFR0.20362584
129GRK10.20312114
130SGK10.19926962
131MAPKAPK30.19627738
132CDC42BPA0.19554460
133CAMK40.19001352
134ABL10.18882987
135PRKG10.18154618
136FGFR30.17673612
137PRKCG0.17535530
138MAP2K20.17460050
139CDK190.17150785
140PRKACA0.17088286
141IKBKE0.15632066
142FYN0.15441768
143MAP3K40.14182438

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.86738255
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.60628884
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.01179389
4Nitrogen metabolism_Homo sapiens_hsa009102.85004778
5Tryptophan metabolism_Homo sapiens_hsa003802.80706654
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.79476798
7Arginine biosynthesis_Homo sapiens_hsa002202.68080605
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67276060
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.58875803
10Fatty acid degradation_Homo sapiens_hsa000712.49922090
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48700135
12Butanoate metabolism_Homo sapiens_hsa006502.45177527
13Propanoate metabolism_Homo sapiens_hsa006402.33543862
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32783318
15* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.31269425
16Peroxisome_Homo sapiens_hsa041462.24080719
17Complement and coagulation cascades_Homo sapiens_hsa046102.10448576
18* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.01723742
19* Chemical carcinogenesis_Homo sapiens_hsa052042.00485233
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93884703
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92389422
22beta-Alanine metabolism_Homo sapiens_hsa004101.86625736
23Histidine metabolism_Homo sapiens_hsa003401.84492633
24PPAR signaling pathway_Homo sapiens_hsa033201.78100875
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.76981579
26Fatty acid metabolism_Homo sapiens_hsa012121.74993659
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.71784442
28Retinol metabolism_Homo sapiens_hsa008301.66230140
29Caffeine metabolism_Homo sapiens_hsa002321.65327373
30Bile secretion_Homo sapiens_hsa049761.63100035
31Pyruvate metabolism_Homo sapiens_hsa006201.60529452
32Phenylalanine metabolism_Homo sapiens_hsa003601.59899489
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.58912595
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54825273
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.54335986
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53097389
37Sulfur metabolism_Homo sapiens_hsa009201.50718864
38Selenocompound metabolism_Homo sapiens_hsa004501.45137924
39Carbon metabolism_Homo sapiens_hsa012001.32935215
40Starch and sucrose metabolism_Homo sapiens_hsa005001.32571481
41Folate biosynthesis_Homo sapiens_hsa007901.32529814
42Tyrosine metabolism_Homo sapiens_hsa003501.30741376
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29426371
44Vitamin digestion and absorption_Homo sapiens_hsa049771.27621895
45Staphylococcus aureus infection_Homo sapiens_hsa051501.23976500
46Fatty acid elongation_Homo sapiens_hsa000621.23830656
47Biosynthesis of amino acids_Homo sapiens_hsa012301.19893248
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.16167926
49* Glutathione metabolism_Homo sapiens_hsa004801.15956343
50Sphingolipid metabolism_Homo sapiens_hsa006001.12724611
51Arginine and proline metabolism_Homo sapiens_hsa003301.10627503
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07255137
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06890359
54ABC transporters_Homo sapiens_hsa020101.06846071
55Steroid biosynthesis_Homo sapiens_hsa001001.04517040
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.01901132
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96938779
58Fat digestion and absorption_Homo sapiens_hsa049750.94924006
59Lysine degradation_Homo sapiens_hsa003100.91119810
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79152919
61Huntingtons disease_Homo sapiens_hsa050160.78854554
62Vitamin B6 metabolism_Homo sapiens_hsa007500.78068733
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77966486
64Sulfur relay system_Homo sapiens_hsa041220.77018100
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76368667
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71905430
67Glycerolipid metabolism_Homo sapiens_hsa005610.69506156
68Pentose phosphate pathway_Homo sapiens_hsa000300.64885249
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64332300
70Tight junction_Homo sapiens_hsa045300.53473699
71Metabolic pathways_Homo sapiens_hsa011000.49021806
72Fructose and mannose metabolism_Homo sapiens_hsa000510.46147491
73Pancreatic secretion_Homo sapiens_hsa049720.45467502
74One carbon pool by folate_Homo sapiens_hsa006700.43169426
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40082949
76Fatty acid biosynthesis_Homo sapiens_hsa000610.31253520
77Galactose metabolism_Homo sapiens_hsa000520.28435195
78Collecting duct acid secretion_Homo sapiens_hsa049660.28127063
79Mineral absorption_Homo sapiens_hsa049780.20248735
80Renin-angiotensin system_Homo sapiens_hsa046140.15168417
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15099376
82Insulin resistance_Homo sapiens_hsa049310.15082743
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.14835544
84Circadian rhythm_Homo sapiens_hsa047100.14220359
85Ether lipid metabolism_Homo sapiens_hsa005650.14153612
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12872513
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11440490
88Protein digestion and absorption_Homo sapiens_hsa049740.11330164
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.09340961
90Linoleic acid metabolism_Homo sapiens_hsa005910.06785500
91Prion diseases_Homo sapiens_hsa050200.06645376
92Thyroid hormone synthesis_Homo sapiens_hsa049180.05737896
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.05689814
94Glucagon signaling pathway_Homo sapiens_hsa049220.05221076
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.04281367
96N-Glycan biosynthesis_Homo sapiens_hsa005100.03825826
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03727711
98African trypanosomiasis_Homo sapiens_hsa051430.03678456
99Arachidonic acid metabolism_Homo sapiens_hsa005900.00684881
100Regulation of autophagy_Homo sapiens_hsa04140-0.2001314
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1874267
102Insulin signaling pathway_Homo sapiens_hsa04910-0.1814435
103Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1474609
104Hepatitis C_Homo sapiens_hsa05160-0.1386691
105Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1317381
106Lysosome_Homo sapiens_hsa04142-0.0954547
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0864499
108Bladder cancer_Homo sapiens_hsa05219-0.0828991
109Other glycan degradation_Homo sapiens_hsa00511-0.0530790
110Salivary secretion_Homo sapiens_hsa04970-0.0469018
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0403741
112Choline metabolism in cancer_Homo sapiens_hsa05231-0.0348805
113Oxidative phosphorylation_Homo sapiens_hsa00190-0.0340563
114Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0315886
115AMPK signaling pathway_Homo sapiens_hsa04152-0.0285832
116Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0102845
117Amoebiasis_Homo sapiens_hsa05146-0.0096636

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