GSTA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.53634674
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.53634674
3regulation of cilium movement (GO:0003352)7.48338475
4left/right pattern formation (GO:0060972)7.47531591
5L-phenylalanine metabolic process (GO:0006558)7.20804780
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.20804780
7aromatic amino acid family catabolic process (GO:0009074)6.80074046
8ventricular system development (GO:0021591)6.70447664
9left/right axis specification (GO:0070986)6.29721295
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.23463125
11tryptophan catabolic process (GO:0006569)6.14728978
12indole-containing compound catabolic process (GO:0042436)6.14728978
13indolalkylamine catabolic process (GO:0046218)6.14728978
14androgen biosynthetic process (GO:0006702)6.12254973
15kynurenine metabolic process (GO:0070189)5.99328600
16bile acid biosynthetic process (GO:0006699)5.91578964
17tryptophan metabolic process (GO:0006568)5.78604523
18glyoxylate metabolic process (GO:0046487)5.71269538
19intraciliary transport (GO:0042073)5.70560087
20urea metabolic process (GO:0019627)5.62329278
21urea cycle (GO:0000050)5.62329278
22alpha-linolenic acid metabolic process (GO:0036109)5.62039761
23negative regulation of fibrinolysis (GO:0051918)5.50645280
24high-density lipoprotein particle remodeling (GO:0034375)5.50485041
25microtubule bundle formation (GO:0001578)5.46299287
26sulfur amino acid catabolic process (GO:0000098)5.43385495
27cysteine metabolic process (GO:0006534)5.39175729
28cilium organization (GO:0044782)5.39125425
29primary alcohol catabolic process (GO:0034310)5.38351610
30complement activation, alternative pathway (GO:0006957)5.29830965
31regulation of fibrinolysis (GO:0051917)5.29760385
32protein carboxylation (GO:0018214)5.27104642
33peptidyl-glutamic acid carboxylation (GO:0017187)5.27104642
34regulation of protein activation cascade (GO:2000257)5.21234909
35nitrogen cycle metabolic process (GO:0071941)5.17594464
36cilium assembly (GO:0042384)5.10370085
37serine family amino acid catabolic process (GO:0009071)5.08367794
38bile acid metabolic process (GO:0008206)5.06761887
39vitamin transmembrane transport (GO:0035461)4.96865167
40aromatic amino acid family metabolic process (GO:0009072)4.94239945
41homocysteine metabolic process (GO:0050667)4.88350716
42regulation of complement activation (GO:0030449)4.87894712
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87227491
44regulation of cholesterol esterification (GO:0010872)4.80833466
45reverse cholesterol transport (GO:0043691)4.79515627
46tyrosine metabolic process (GO:0006570)4.78394231
47regulation of triglyceride catabolic process (GO:0010896)4.78246083
48plasma lipoprotein particle remodeling (GO:0034369)4.69693251
49protein-lipid complex remodeling (GO:0034368)4.69693251
50macromolecular complex remodeling (GO:0034367)4.69693251
51amino-acid betaine metabolic process (GO:0006577)4.63598555
52alpha-amino acid catabolic process (GO:1901606)4.63542886
53progesterone metabolic process (GO:0042448)4.60277607
54lysine metabolic process (GO:0006553)4.59798547
55lysine catabolic process (GO:0006554)4.59798547
56triglyceride homeostasis (GO:0070328)4.57120755
57acylglycerol homeostasis (GO:0055090)4.57120755
58negative regulation of sterol transport (GO:0032372)4.50262453
59negative regulation of cholesterol transport (GO:0032375)4.50262453
60phospholipid efflux (GO:0033700)4.50235207
61ethanol metabolic process (GO:0006067)4.47958580
62cilium morphogenesis (GO:0060271)4.41593781
63cellular glucuronidation (GO:0052695)4.41052518
64bile acid and bile salt transport (GO:0015721)4.39172952
65ethanol oxidation (GO:0006069)4.37723097
66plasma lipoprotein particle clearance (GO:0034381)4.36945877
67glycine metabolic process (GO:0006544)4.36779443
68cellular ketone body metabolic process (GO:0046950)4.36026503
69indolalkylamine metabolic process (GO:0006586)4.35318965
70coenzyme catabolic process (GO:0009109)4.34052059
71glucocorticoid biosynthetic process (GO:0006704)4.30429457
72imidazole-containing compound metabolic process (GO:0052803)4.28736877
73cellular biogenic amine catabolic process (GO:0042402)4.28644678
74amine catabolic process (GO:0009310)4.28644678
75protein localization to cilium (GO:0061512)4.28508666
76pyrimidine-containing compound transmembrane transport (GO:0072531)4.28165857
77cellular amino acid catabolic process (GO:0009063)4.27740447
78regulation of microtubule-based movement (GO:0060632)4.23523890
79benzene-containing compound metabolic process (GO:0042537)4.21654869
80cellular component assembly involved in morphogenesis (GO:0010927)4.20521489
81glutamate metabolic process (GO:0006536)4.20084445
82serine family amino acid metabolic process (GO:0009069)4.16844668
83cholesterol efflux (GO:0033344)4.14847147
84nucleoside diphosphate phosphorylation (GO:0006165)4.13619617
85lung epithelium development (GO:0060428)4.08825207
86microtubule-based movement (GO:0007018)4.08551861
87cellular modified amino acid catabolic process (GO:0042219)4.04132866
88negative regulation of T cell differentiation in thymus (GO:0033085)4.04029899
89drug catabolic process (GO:0042737)4.03083404
90aldehyde catabolic process (GO:0046185)4.02993851
91arginine metabolic process (GO:0006525)3.97245332
92dicarboxylic acid biosynthetic process (GO:0043650)3.96667398
93cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.96438194
94low-density lipoprotein particle remodeling (GO:0034374)3.96035611
95serine family amino acid biosynthetic process (GO:0009070)3.95475844
96glucuronate metabolic process (GO:0019585)3.94991064
97uronic acid metabolic process (GO:0006063)3.94991064
98plasma lipoprotein particle assembly (GO:0034377)3.94164848
99fibrinolysis (GO:0042730)3.93616647
100estrogen biosynthetic process (GO:0006703)3.93390924
101androgen metabolic process (GO:0008209)3.83180533
102negative regulation of lipase activity (GO:0060192)3.80660850
103ketone body metabolic process (GO:1902224)3.77362126
104carboxylic acid catabolic process (GO:0046395)3.76038633
105organic acid catabolic process (GO:0016054)3.76038633
106cofactor catabolic process (GO:0051187)3.75534666
107blood coagulation, intrinsic pathway (GO:0007597)3.75191175
108short-chain fatty acid metabolic process (GO:0046459)3.74043183
109phospholipid homeostasis (GO:0055091)3.73920692
110positive regulation of lipid catabolic process (GO:0050996)3.72967199
111very-low-density lipoprotein particle assembly (GO:0034379)3.72286128
112sperm capacitation (GO:0048240)3.72276282
113acetyl-CoA metabolic process (GO:0006084)3.71957071
114regulation of bile acid biosynthetic process (GO:0070857)3.71929097
115response to nitrosative stress (GO:0051409)3.71415002
116cholesterol homeostasis (GO:0042632)3.71206066
117positive regulation of triglyceride lipase activity (GO:0061365)3.71032365
118positive regulation of lipoprotein lipase activity (GO:0051006)3.71032365
119melanin biosynthetic process (GO:0042438)3.69756683
120complement activation, classical pathway (GO:0006958)3.68608858
121hormone biosynthetic process (GO:0042446)3.68322471
122complement activation (GO:0006956)3.67095547
123cell projection assembly (GO:0030031)3.66618392
124retinal rod cell development (GO:0046548)3.65767435
125sterol homeostasis (GO:0055092)3.65148484
126one-carbon compound transport (GO:0019755)3.64305009
127protein activation cascade (GO:0072376)3.64253853
128diterpenoid biosynthetic process (GO:0016102)3.64192215
129cytolysis (GO:0019835)3.60595739
130regulation of cholesterol homeostasis (GO:2000188)3.58377028
131flavonoid metabolic process (GO:0009812)3.58290335
132cellular response to antibiotic (GO:0071236)3.56821674
133plasma lipoprotein particle organization (GO:0071827)3.56535203
134response to xenobiotic stimulus (GO:0009410)3.55914227
135nicotinamide nucleotide biosynthetic process (GO:0019359)3.54467909
136centriole assembly (GO:0098534)3.53898663
137* glutathione derivative biosynthetic process (GO:1901687)3.46842380
138* glutathione derivative metabolic process (GO:1901685)3.46842380
139negative regulation of humoral immune response (GO:0002921)3.42693722
140terpenoid biosynthetic process (GO:0016114)3.41403174
141C21-steroid hormone metabolic process (GO:0008207)3.37302930
142cytoplasmic microtubule organization (GO:0031122)3.33368454
143glomerular epithelial cell development (GO:0072310)3.32248570
144regulation of interleukin-5 production (GO:0032674)3.31697267
145melanin metabolic process (GO:0006582)3.31019766
146negative regulation of B cell mediated immunity (GO:0002713)3.26792606
147negative regulation of immunoglobulin mediated immune response (GO:0002890)3.26792606
148tolerance induction (GO:0002507)3.25117932
149C21-steroid hormone biosynthetic process (GO:0006700)3.24360883
150glucocorticoid metabolic process (GO:0008211)3.18548464
151amyloid precursor protein catabolic process (GO:0042987)3.15479369
152secondary metabolite biosynthetic process (GO:0044550)3.14602103
153regulation of autophagic vacuole assembly (GO:2000785)3.14384145
154determination of left/right symmetry (GO:0007368)3.14012994
155response to follicle-stimulating hormone (GO:0032354)3.06532999
156multicellular organismal water homeostasis (GO:0050891)3.06228363
157determination of bilateral symmetry (GO:0009855)3.03825623
158establishment of apical/basal cell polarity (GO:0035089)3.02963647
159ketone biosynthetic process (GO:0042181)3.00107214
160lateral ventricle development (GO:0021670)3.00085580
161primary alcohol metabolic process (GO:0034308)2.98541159
162specification of symmetry (GO:0009799)2.98501148
163photoreceptor cell maintenance (GO:0045494)2.94093199
164exogenous drug catabolic process (GO:0042738)2.84863411
165Leydig cell differentiation (GO:0033327)2.83906723
166sperm motility (GO:0030317)2.83777381
167multicellular organismal aging (GO:0010259)2.83667229
168regulation of vacuole organization (GO:0044088)2.81840834
169negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.80741830
170retinol metabolic process (GO:0042572)2.79335702
171cornea development in camera-type eye (GO:0061303)2.72570351
172cellular response to gonadotropin stimulus (GO:0071371)2.71397571
173regulation of interleukin-13 production (GO:0032656)2.66330596
174response to leptin (GO:0044321)2.64392104
175retinoic acid metabolic process (GO:0042573)2.61208837
176establishment of planar polarity (GO:0001736)2.60632193
177establishment of tissue polarity (GO:0007164)2.60632193
178water homeostasis (GO:0030104)2.60596825
179regulation of germinal center formation (GO:0002634)2.59862653
180regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.59072501
181retinal cone cell development (GO:0046549)2.56216718
182apical protein localization (GO:0045176)2.52520717
183GTP biosynthetic process (GO:0006183)2.51228324
184carnitine metabolic process (GO:0009437)2.50603535
185smoothened signaling pathway (GO:0007224)2.49887782
186establishment of monopolar cell polarity (GO:0061162)2.48723845
187establishment or maintenance of monopolar cell polarity (GO:0061339)2.48723845
188cellular response to toxic substance (GO:0097237)2.47497108
189regulation of gonadotropin secretion (GO:0032276)2.39227370
190calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.38796013
191axonemal dynein complex assembly (GO:0070286)18.9853152
192cilium or flagellum-dependent cell motility (GO:0001539)15.3573149
193cilium movement (GO:0003341)15.0190904
194epithelial cilium movement (GO:0003351)13.8244528
195epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)13.2407431
196motile cilium assembly (GO:0044458)13.0962404
197axoneme assembly (GO:0035082)10.2297487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.31901562
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13870686
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.96172380
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.46619427
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.25435804
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.09334124
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.03333876
8* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.00088573
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.03200937
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.99305264
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.95945721
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15309548
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08198021
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.06284737
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04558246
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.00746687
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.8052825
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98337264
19AHR_22903824_ChIP-Seq_MCF-7_Human1.97548577
20VDR_22108803_ChIP-Seq_LS180_Human1.94952161
21DROSHA_22980978_ChIP-Seq_HELA_Human1.93334906
22* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.87389863
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81664573
24ARNT_22903824_ChIP-Seq_MCF-7_Human1.68735702
25NR3C1_21868756_ChIP-Seq_MCF10A_Human1.62567351
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.60323160
27* CLOCK_20551151_ChIP-Seq_293T_Human1.58246999
28GATA1_22025678_ChIP-Seq_K562_Human1.56816351
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55883501
30HTT_18923047_ChIP-ChIP_STHdh_Human1.52760549
31* TP63_23658742_ChIP-Seq_EP156T_Human1.49390338
32ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48629213
33STAT1_20625510_ChIP-Seq_HELA_Human1.46783041
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42890422
35HNF4A_19822575_ChIP-Seq_HepG2_Human1.39940473
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36876205
37PHF8_20622853_ChIP-Seq_HELA_Human1.32527338
38TCF4_22108803_ChIP-Seq_LS180_Human1.30740405
39* RUNX1_27514584_Chip-Seq_MCF-7_Human1.27962444
40CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27550247
41HNFA_21074721_ChIP-Seq_CACO-2_Human1.26644677
42PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.25658595
43* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24516037
44P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21900368
45KLF5_25053715_ChIP-Seq_YYC3_Human1.21479943
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20763692
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18903131
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18534659
49SMRT_27268052_Chip-Seq_Bcells_Human1.17262279
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17176619
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17023772
52ETV1_20927104_ChIP-Seq_GIST48_Human1.16991529
53RBPJ_21746931_ChIP-Seq_IB4_Human1.16727234
54* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15016032
55FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13059320
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.13059320
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.12838327
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09178143
59ERG_20517297_ChIP-Seq_VCAP_Human1.08738559
60TBL1_22424771_ChIP-Seq_293T_Human1.08504950
61GATA6_21074721_ChIP-Seq_CACO-2_Human1.06795491
62NFYA_21822215_ChIP-Seq_K562_Human1.06659087
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06558518
64TP63_22573176_ChIP-Seq_HFKS_Human1.06113887
65SMAD4_21799915_ChIP-Seq_A2780_Human1.03865970
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03762512
67GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.03652384
68SMAD3_21741376_ChIP-Seq_HESCs_Human1.03300784
69NFYB_21822215_ChIP-Seq_K562_Human1.01493644
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01165718
71* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99345114
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99096764
73RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98521189
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98454792
75CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98390963
76SMAD3_21741376_ChIP-Seq_EPCs_Human0.96670675
77SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95826771
78CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95545008
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95295160
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94215362
81SOX2_21211035_ChIP-Seq_LN229_Human0.94147832
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93549657
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93064194
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92329462
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91648178
86TP53_18474530_ChIP-ChIP_U2OS_Human0.91054700
87ER_23166858_ChIP-Seq_MCF-7_Human0.89919642
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89910555
89CBP_20019798_ChIP-Seq_JUKART_Human0.89203159
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89203159
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88479141
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88479141
93GATA4_25053715_ChIP-Seq_YYC3_Human0.88114993
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87379916
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85718507
96IRF8_22096565_ChIP-ChIP_GC-B_Human0.83883181
97RXR_22108803_ChIP-Seq_LS180_Human0.83488006
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82517344
99ZNF263_19887448_ChIP-Seq_K562_Human0.81197882
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81182591
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79555640
102KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79045237
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77757282
104* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77635770
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75932728
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75351799
107SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75176027
108ESR2_21235772_ChIP-Seq_MCF-7_Human0.74634522
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71768632
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70566563
111* RARA_24833708_ChIP-Seq_LIVER_Mouse0.70022743
112* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68480610
113* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68480610
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67616740
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62234924
116RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62135800
117BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61972013
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60842010
119* RARB_24833708_ChIP-Seq_LIVER_Mouse0.59116109
120CEBPB_22108803_ChIP-Seq_LS180_Human0.58458034
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.57619113
122FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56820870
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.56066527
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.53305046
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53157027
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.52864692
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52408255
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51640900
129PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51303614
130MYC_19915707_ChIP-ChIP_AK7_Human0.51027535
131ESET_19884257_ChIP-Seq_ESCs_Mouse0.50771255
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.50510898
133STAT1_17558387_ChIP-Seq_HELA_Human0.50239738
134* AR_20517297_ChIP-Seq_VCAP_Human0.50072888
135LXR_22292898_ChIP-Seq_THP-1_Human0.49305502
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.48455909
137CBP_21632823_ChIP-Seq_H3396_Human0.48366390
138TAF15_26573619_Chip-Seq_HEK293_Human0.47822858
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47010491
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.46056794
141P53_21459846_ChIP-Seq_SAOS-2_Human0.45069351
142PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44745869
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43926528
144BCAT_22108803_ChIP-Seq_LS180_Human0.43773528
145GATA6_25053715_ChIP-Seq_YYC3_Human0.43055552
146E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.42714314
147GATA1_19941826_ChIP-Seq_K562_Human0.42670963
148GATA2_19941826_ChIP-Seq_K562_Human0.40852517
149SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.39522850
150TAF2_19829295_ChIP-Seq_ESCs_Human0.39289256
151SOX2_20726797_ChIP-Seq_SW620_Human0.39013940
152GATA1_19941827_ChIP-Seq_MEL_Mouse0.38432143
153STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38302047
154ERG_21242973_ChIP-ChIP_JURKAT_Human0.37877441
155* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37605475
156GATA3_24758297_ChIP-Seq_MCF-7_Human0.37564113
157FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.37037044
158MYC_27129775_Chip-Seq_CORNEA_Mouse0.36235151
159GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.36032022
160CDX2_22108803_ChIP-Seq_LS180_Human0.35885133
161FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.35858685
162ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.34990895
163FOXH1_21741376_ChIP-Seq_EPCs_Human0.34879375
164LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34549752
165CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34420329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.34777515
2MP0005360_urolithiasis7.42592396
3MP0005085_abnormal_gallbladder_physiolo6.41275332
4MP0005365_abnormal_bile_salt6.18527116
5MP0008875_abnormal_xenobiotic_pharmacok5.32330458
6MP0002653_abnormal_ependyma_morphology4.83985848
7MP0001984_abnormal_olfaction4.41855142
8MP0003806_abnormal_nucleotide_metabolis4.24514965
9MP0003252_abnormal_bile_duct3.88974150
10MP0000566_synostosis3.72957156
11MP0010329_abnormal_lipoprotein_level3.58658206
12MP0000372_irregular_coat_pigmentation3.53432358
13MP0003136_yellow_coat_color3.44692478
14MP0009840_abnormal_foam_cell3.18314886
15MP0005083_abnormal_biliary_tract3.12325454
16MP0002909_abnormal_adrenal_gland3.10797142
17MP0009780_abnormal_chondrocyte_physiolo2.79147434
18MP0003195_calcinosis2.76925605
19MP0005332_abnormal_amino_acid2.75933060
20MP0004133_heterotaxia2.71757124
21MP0002160_abnormal_reproductive_system2.70191069
22MP0001666_abnormal_nutrient_absorption2.57201314
23MP0004043_abnormal_pH_regulation2.33997585
24MP0003191_abnormal_cellular_cholesterol2.27189220
25MP0008995_early_reproductive_senescence2.26550978
26MP0004019_abnormal_vitamin_homeostasis2.21968863
27MP0000383_abnormal_hair_follicle2.15938877
28MP0000609_abnormal_liver_physiology2.14531589
29MP0002118_abnormal_lipid_homeostasis2.10748530
30MP0005623_abnormal_meninges_morphology2.10456965
31MP0002277_abnormal_respiratory_mucosa2.03538896
32MP0002138_abnormal_hepatobiliary_system2.03321861
33MP0008789_abnormal_olfactory_epithelium1.92168302
34MP0003868_abnormal_feces_composition1.89210785
35MP0005319_abnormal_enzyme/_coenzyme1.83130221
36MP0002282_abnormal_trachea_morphology1.82223180
37MP0005377_hearing/vestibular/ear_phenot1.78770746
38MP0003878_abnormal_ear_physiology1.78770746
39MP0010678_abnormal_skin_adnexa1.69747228
40MP0001764_abnormal_homeostasis1.68362161
41MP0005389_reproductive_system_phenotype1.58877339
42MP0005584_abnormal_enzyme/coenzyme_acti1.56470162
43MP0009697_abnormal_copulation1.56358210
44MP0009379_abnormal_foot_pigmentation1.55040836
45MP0001324_abnormal_eye_pigmentation1.50653078
46MP0001765_abnormal_ion_homeostasis1.41506645
47MP0005451_abnormal_body_composition1.40924078
48MP0003186_abnormal_redox_activity1.40392903
49MP0003011_delayed_dark_adaptation1.40221674
50MP0002938_white_spotting1.39401267
51MP0005171_absent_coat_pigmentation1.38034387
52MP0010030_abnormal_orbit_morphology1.36047179
53MP0009643_abnormal_urine_homeostasis1.26642964
54MP0003656_abnormal_erythrocyte_physiolo1.21900949
55MP0000013_abnormal_adipose_tissue1.21238134
56MP0005253_abnormal_eye_physiology1.20409094
57MP0000598_abnormal_liver_morphology1.16178612
58MP0005647_abnormal_sex_gland1.13308314
59MP0003123_paternal_imprinting1.12361677
60MP0003705_abnormal_hypodermis_morpholog1.11007803
61MP0001485_abnormal_pinna_reflex1.10707252
62MP0002638_abnormal_pupillary_reflex1.08352087
63MP0003283_abnormal_digestive_organ1.07993018
64MP0009764_decreased_sensitivity_to1.07386428
65MP0002254_reproductive_system_inflammat1.05747685
66MP0005409_darkened_coat_color1.01940772
67MP0000604_amyloidosis0.99670537
68MP0010368_abnormal_lymphatic_system0.97858618
69* MP0009763_increased_sensitivity_to0.95718879
70MP0005551_abnormal_eye_electrophysiolog0.94094918
71MP0005636_abnormal_mineral_homeostasis0.92536281
72MP0005499_abnormal_olfactory_system0.91716069
73MP0005394_taste/olfaction_phenotype0.91716069
74MP0005503_abnormal_tendon_morphology0.91393050
75MP0005408_hypopigmentation0.88981667
76MP0002233_abnormal_nose_morphology0.88941892
77MP0005670_abnormal_white_adipose0.87962802
78MP0002098_abnormal_vibrissa_morphology0.87411349
79MP0008469_abnormal_protein_level0.86972457
80MP0009642_abnormal_blood_homeostasis0.85734890
81MP0008004_abnormal_stomach_pH0.84289834
82MP0010234_abnormal_vibrissa_follicle0.83860924
83MP0001929_abnormal_gametogenesis0.83340391
84MP0003698_abnormal_male_reproductive0.82357423
85MP0002876_abnormal_thyroid_physiology0.81770108
86MP0005376_homeostasis/metabolism_phenot0.80741253
87MP0005075_abnormal_melanosome_morpholog0.80238249
88MP0006036_abnormal_mitochondrial_physio0.80229770
89MP0005084_abnormal_gallbladder_morpholo0.79801837
90MP0000647_abnormal_sebaceous_gland0.79588696
91MP0002734_abnormal_mechanical_nocicepti0.78571071
92MP0002078_abnormal_glucose_homeostasis0.77128764
93MP0005220_abnormal_exocrine_pancreas0.73140122
94MP0004130_abnormal_muscle_cell0.72487121
95MP0002971_abnormal_brown_adipose0.71861516
96MP0005187_abnormal_penis_morphology0.71821846
97MP0005334_abnormal_fat_pad0.71121284
98MP0003690_abnormal_glial_cell0.69295954
99MP0003941_abnormal_skin_development0.69267569
100MP0001661_extended_life_span0.67331563
101MP0002896_abnormal_bone_mineralization0.67007911
102MP0005535_abnormal_body_temperature0.66597075
103MP0006276_abnormal_autonomic_nervous0.65994116
104* MP0009765_abnormal_xenobiotic_induced0.65228287
105MP0005266_abnormal_metabolism0.65107488
106MP0009053_abnormal_anal_canal0.63608957
107MP0005508_abnormal_skeleton_morphology0.63113497
108MP0001756_abnormal_urination0.63022814
109MP0001502_abnormal_circadian_rhythm0.59556524
110MP0000015_abnormal_ear_pigmentation0.59086562
111MP0000639_abnormal_adrenal_gland0.57798532
112MP0004782_abnormal_surfactant_physiolog0.57411920
113MP0009046_muscle_twitch0.57134590
114MP0003329_amyloid_beta_deposits0.56999570
115MP0009703_decreased_birth_body0.56477111
116MP0005448_abnormal_energy_balance0.53562379
117MP0001188_hyperpigmentation0.52139784
118MP0006035_abnormal_mitochondrial_morpho0.51573819
119MP0000371_diluted_coat_color0.51321713
120MP0000026_abnormal_inner_ear0.50382079
121MP0005464_abnormal_platelet_physiology0.49751079
122MP0005395_other_phenotype0.49572762
123MP0003937_abnormal_limbs/digits/tail_de0.49466510
124MP0002136_abnormal_kidney_physiology0.49010984
125MP0005248_abnormal_Harderian_gland0.47570841
126MP0002928_abnormal_bile_duct0.47288268
127MP0003724_increased_susceptibility_to0.47096606
128MP0002229_neurodegeneration0.46649574
129MP0003638_abnormal_response/metabolism_0.45457378
130MP0003718_maternal_effect0.45156845
131MP0003453_abnormal_keratinocyte_physiol0.44112581
132MP0008874_decreased_physiological_sensi0.43476045
133MP0002210_abnormal_sex_determination0.42742924
134MP0002822_catalepsy0.42664545
135MP0005666_abnormal_adipose_tissue0.41726896
136MP0003075_altered_response_to0.41665986
137MP0003953_abnormal_hormone_level0.41287564
138MP0002837_dystrophic_cardiac_calcinosis0.40791283
139MP0008872_abnormal_physiological_respon0.40130347
140MP0003436_decreased_susceptibility_to0.39021798
141MP0005166_decreased_susceptibility_to0.37733876
142MP0004381_abnormal_hair_follicle0.37318729
143MP0002796_impaired_skin_barrier0.37241901
144MP0009115_abnormal_fat_cell0.36977046
145* MP0008873_increased_physiological_sensi0.35826096
146MP0002168_other_aberrant_phenotype0.35454180
147MP0009672_abnormal_birth_weight0.33979185
148MP0000249_abnormal_blood_vessel0.32884399
149MP0000579_abnormal_nail_morphology0.32540385
150MP0004883_abnormal_blood_vessel0.32163682
151MP0000230_abnormal_systemic_arterial0.31808258
152MP0002970_abnormal_white_adipose0.31362834
153MP0002132_abnormal_respiratory_system0.31067221
154MP0006082_CNS_inflammation0.30454635
155MP0009384_cardiac_valve_regurgitation0.30281186
156MP0001853_heart_inflammation0.29948290
157MP0001243_abnormal_dermal_layer0.29930125
158MP0001881_abnormal_mammary_gland0.28887612
159MP0005164_abnormal_response_to0.28765260
160MP0002060_abnormal_skin_morphology0.27354415
161MP0001845_abnormal_inflammatory_respons0.27255952
162MP0002090_abnormal_vision0.26536694

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.52592995
2Chronic bronchitis (HP:0004469)7.45679298
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.39535159
4Deep venous thrombosis (HP:0002625)7.38108936
5Intrahepatic cholestasis (HP:0001406)7.27093315
6Bronchiectasis (HP:0002110)6.80205400
7Abnormality of monocarboxylic acid metabolism (HP:0010996)6.70585274
8Prolonged partial thromboplastin time (HP:0003645)6.47961406
9Hypobetalipoproteinemia (HP:0003563)6.40261766
10Xanthomatosis (HP:0000991)6.24450741
11Nasal polyposis (HP:0100582)6.06645244
12Hyperlipoproteinemia (HP:0010980)5.54723027
13Complement deficiency (HP:0004431)5.31342313
14Abnormality of the nasal mucosa (HP:0000433)4.98309814
15Hypolipoproteinemia (HP:0010981)4.77638389
16Joint hemorrhage (HP:0005261)4.75681644
17Hyperammonemia (HP:0001987)4.62380641
18Epidermoid cyst (HP:0200040)4.54968639
19Hyperglycinemia (HP:0002154)4.46555500
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.38043986
21Abnormality of the common coagulation pathway (HP:0010990)4.33654846
22Abnormality of methionine metabolism (HP:0010901)4.30581169
23Ketosis (HP:0001946)4.26684239
24Abnormality of sulfur amino acid metabolism (HP:0004339)4.25255132
25Infertility (HP:0000789)4.23218248
26Abnormality of glutamine family amino acid metabolism (HP:0010902)4.20592845
27Hypoalphalipoproteinemia (HP:0003233)4.16195689
28Abnormality of aspartate family amino acid metabolism (HP:0010899)4.15991805
29Fat malabsorption (HP:0002630)4.14437944
30Hyperglycinuria (HP:0003108)4.06465455
31Chronic sinusitis (HP:0011109)4.04732371
32Abnormality of glycine metabolism (HP:0010895)4.01005654
33Abnormality of serine family amino acid metabolism (HP:0010894)4.01005654
34Bronchitis (HP:0012387)3.96198003
35Abnormality of complement system (HP:0005339)3.86597493
36Hypoglycemic coma (HP:0001325)3.86382540
37Abnormality of pyrimidine metabolism (HP:0004353)3.84153352
38Male infertility (HP:0003251)3.82204186
39Recurrent sinusitis (HP:0011108)3.74697301
40Abnormality of the intrinsic pathway (HP:0010989)3.73298441
41Conjugated hyperbilirubinemia (HP:0002908)3.71998256
42Occipital encephalocele (HP:0002085)3.68602415
43Hypercholesterolemia (HP:0003124)3.62748580
44Recurrent otitis media (HP:0000403)3.55491425
45True hermaphroditism (HP:0010459)3.47173493
46Pancreatic fibrosis (HP:0100732)3.44531102
47Abnormality of fatty-acid metabolism (HP:0004359)3.39659895
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.38854789
49Hyperbilirubinemia (HP:0002904)3.33883220
50Steatorrhea (HP:0002570)3.16850974
51Molar tooth sign on MRI (HP:0002419)3.14690461
52Abnormality of midbrain morphology (HP:0002418)3.14690461
53Delayed CNS myelination (HP:0002188)3.12459460
54Abnormality of nucleobase metabolism (HP:0010932)3.12012956
55Abnormality of serum amino acid levels (HP:0003112)3.10682171
56Male pseudohermaphroditism (HP:0000037)3.07135748
57Ketoacidosis (HP:0001993)3.05085724
58Hepatocellular carcinoma (HP:0001402)3.00866207
59Myocardial infarction (HP:0001658)2.93006996
60Hypochromic microcytic anemia (HP:0004840)2.88475593
61Pancreatic cysts (HP:0001737)2.86925868
62Spontaneous abortion (HP:0005268)2.86581554
63Nephronophthisis (HP:0000090)2.85430744
64Renal salt wasting (HP:0000127)2.83014725
65Metabolic acidosis (HP:0001942)2.79507790
66Skin nodule (HP:0200036)2.78999780
67Abnormality of purine metabolism (HP:0004352)2.75942758
68Systemic lupus erythematosus (HP:0002725)2.72040361
69Cystic liver disease (HP:0006706)2.70728213
70Chronic hepatic failure (HP:0100626)2.70688590
71Vascular calcification (HP:0004934)2.64587130
72Lethargy (HP:0001254)2.63335175
73Dicarboxylic aciduria (HP:0003215)2.60605260
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60605260
75Chronic otitis media (HP:0000389)2.57787968
76Gout (HP:0001997)2.57190248
77Acanthocytosis (HP:0001927)2.54339559
78Spastic diplegia (HP:0001264)2.50066552
79Hypoglycemic seizures (HP:0002173)2.46726959
80Medial flaring of the eyebrow (HP:0010747)2.46419657
81Abnormal gallbladder morphology (HP:0012437)2.46364900
82Tubulointerstitial nephritis (HP:0001970)2.45775291
83Cerebral edema (HP:0002181)2.41584613
84Atelectasis (HP:0100750)2.41565832
85Glomerulonephritis (HP:0000099)2.41199985
86Mitral stenosis (HP:0001718)2.40726454
87Cholelithiasis (HP:0001081)2.38880288
88Postaxial foot polydactyly (HP:0001830)2.35084912
89Cardiovascular calcification (HP:0011915)2.34681873
90Irritability (HP:0000737)2.34669609
91Abnormal gallbladder physiology (HP:0012438)2.33850686
92Cholecystitis (HP:0001082)2.33850686
93Recurrent gram-negative bacterial infections (HP:0005420)2.31207651
94Neonatal onset (HP:0003623)2.31073495
95Esophageal varix (HP:0002040)2.28968172
96Decreased circulating renin level (HP:0003351)2.26269530
97Hyperactive renin-angiotensin system (HP:0000841)2.25575187
98Amyloidosis (HP:0011034)2.25565917
99Malnutrition (HP:0004395)2.25077394
100Pancreatitis (HP:0001733)2.15173884
101Abnormality of the renal medulla (HP:0100957)2.13898339
102Brushfield spots (HP:0001088)2.13695609
103Sensorimotor neuropathy (HP:0007141)2.12772189
104Enlarged kidneys (HP:0000105)2.11267079
105Gingival bleeding (HP:0000225)2.11152838
106Menorrhagia (HP:0000132)2.10890984
107Vomiting (HP:0002013)2.08809345
108Late onset (HP:0003584)2.08657516
109Hyperaldosteronism (HP:0000859)2.06931325
110Generalized aminoaciduria (HP:0002909)2.06412436
111Congenital primary aphakia (HP:0007707)2.06150779
112Aplasia/Hypoplasia of the tongue (HP:0010295)2.05124497
113Congenital hepatic fibrosis (HP:0002612)2.05042038
114Thrombophlebitis (HP:0004418)2.03458047
115Opisthotonus (HP:0002179)2.02535182
116Hemorrhage of the eye (HP:0011885)2.00794647
117Abnormality of the gallbladder (HP:0005264)2.00515799
118Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.8908678
119Abnormal respiratory motile cilium physiology (HP:0012261)10.8553113
120Abnormal ciliary motility (HP:0012262)10.7250670
121Dynein arm defect of respiratory motile cilia (HP:0012255)10.6055236
122Absent/shortened dynein arms (HP:0200106)10.6055236
123Abnormal respiratory epithelium morphology (HP:0012253)10.6011249
124Abnormal respiratory motile cilium morphology (HP:0005938)10.6011249
125Gait imbalance (HP:0002141)1.99984731
126Rickets (HP:0002748)1.99567942
127Hyperinsulinemic hypoglycemia (HP:0000825)1.97996889
128Poikilocytosis (HP:0004447)1.96843206
129Abnormal cartilage morphology (HP:0002763)1.95387769
130Short nail (HP:0001799)1.93662065
131Abnormality of proline metabolism (HP:0010907)1.93365590
132Hydroxyprolinuria (HP:0003080)1.93365590
133Renal cortical cysts (HP:0000803)1.92096855
134Alkalosis (HP:0001948)1.89478048
135Abnormality of iron homeostasis (HP:0011031)1.87557952
136Tubular atrophy (HP:0000092)1.86757606
137Abnormality of transition element cation homeostasis (HP:0011030)1.86000548
138Furrowed tongue (HP:0000221)1.85339396
139Anencephaly (HP:0002323)1.85018594
140Hypophosphatemic rickets (HP:0004912)1.84724783
141Abnormal enzyme/coenzyme activity (HP:0012379)1.83201124
142Elevated hepatic transaminases (HP:0002910)1.80902699
143Abnormality of vitamin metabolism (HP:0100508)1.79104278
144Tubulointerstitial abnormality (HP:0001969)1.78908183
145Nephritis (HP:0000123)1.76479359
146Hyperuricemia (HP:0002149)1.75782525
147Increased purine levels (HP:0004368)1.75782525
148Nephrogenic diabetes insipidus (HP:0009806)1.74110064
149Oculomotor apraxia (HP:0000657)1.68167107
150Abnormality of permanent molar morphology (HP:0011071)1.66743320
151Abnormality of the dental root (HP:0006486)1.66743320
152Taurodontia (HP:0000679)1.66743320
153Sclerocornea (HP:0000647)1.65855417
154Postaxial hand polydactyly (HP:0001162)1.60069221
155Genital tract atresia (HP:0001827)1.59562569
156Abnormal sex determination (HP:0012244)1.59438571
157Sex reversal (HP:0012245)1.59438571
158Decreased central vision (HP:0007663)1.59398701
159Hypokalemic alkalosis (HP:0001949)1.58356804
160Vaginal atresia (HP:0000148)1.58260842
161Abnormality of the dental pulp (HP:0006479)1.55944668
162Recurrent bronchitis (HP:0002837)1.55929614
163Absent rod-and cone-mediated responses on ERG (HP:0007688)1.55006424
164Median cleft lip (HP:0000161)1.53437435
165Abnormality of molar morphology (HP:0011070)1.53024897
166Abnormality of molar (HP:0011077)1.53024897
167Tubulointerstitial fibrosis (HP:0005576)1.52827522
168Cone-rod dystrophy (HP:0000548)1.51334186
169Absent frontal sinuses (HP:0002688)1.50912378
170Hypoplasia of the uterus (HP:0000013)1.48963190
171Nephropathy (HP:0000112)1.46380116
172Poor coordination (HP:0002370)1.43978092
173Aplasia of the musculature (HP:0100854)1.42406809
174Bifid scrotum (HP:0000048)1.39826937
175Abnormality of renin-angiotensin system (HP:0000847)1.39777004
176Preaxial hand polydactyly (HP:0001177)1.38822040
177Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.32179859
178Bell-shaped thorax (HP:0001591)1.32169137
179Lip pit (HP:0100267)1.27585383
180Polydipsia (HP:0001959)1.27225153
181Abnormal drinking behavior (HP:0030082)1.27225153
182Abnormality of the frontal sinuses (HP:0002687)1.22574372
183Abnormality of dentin (HP:0010299)1.20581903
184Stage 5 chronic kidney disease (HP:0003774)1.20069532
185Aplasia/Hypoplasia of the spleen (HP:0010451)1.17720440
186Asplenia (HP:0001746)1.17253111
187Short thorax (HP:0010306)1.16181011
188Aplasia/hypoplasia of the uterus (HP:0008684)1.13912329
189Congenital sensorineural hearing impairment (HP:0008527)1.11962341
190Retinitis pigmentosa (HP:0000510)1.11938239
191Abnormality of the distal phalanges of the toes (HP:0010182)1.11084154
192Abnormality of macular pigmentation (HP:0008002)1.10860242
193Narrow forehead (HP:0000341)1.10051261
194Abnormal rod and cone electroretinograms (HP:0008323)1.08475823
195Supernumerary spleens (HP:0009799)1.05036324
196Abnormality of the renal cortex (HP:0011035)1.03603970
197Glucose intolerance (HP:0000833)1.01938777
198Adrenal overactivity (HP:0002717)1.00929704
199Abnormality of abdominal situs (HP:0011620)0.99538771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.13404365
2MST46.01818308
3SIK14.59561631
4FGFR44.43606075
5ERN14.16629541
6STK243.63801817
7INSRR3.02138022
8TAOK32.92239660
9ERBB42.82365963
10MAPKAPK32.31007989
11MST1R2.30069842
12PKN22.23738216
13CCNB12.23127374
14MAP2K42.18901593
15PTK2B2.01355195
16FLT31.92101602
17MAPK111.79703544
18LATS11.73490887
19TRIB31.71653092
20PIK3CG1.69742561
21STK391.67297914
22TYK21.66104703
23FRK1.61366647
24DAPK21.58800433
25NEK91.50827405
26STK161.48733183
27FGFR21.44347146
28PTK61.44067241
29ABL21.43700108
30TTK1.34155423
31LRRK21.27155198
32KDR1.23741190
33OXSR11.21030029
34STK101.20664040
35NME11.20129114
36PINK11.18575715
37JAK21.18283590
38PRKAA21.17318229
39MAP3K71.17146376
40TRPM71.16125402
41BCR1.14238480
42MAP2K31.14061021
43MAP3K31.10064567
44MUSK1.07602506
45MAP3K121.07038484
46TLK11.05984301
47STK38L1.05607556
48PNCK1.04808265
49TIE11.04099743
50TESK11.00930540
51JAK11.00884377
52MAP3K140.99903376
53TBK10.99496242
54GRK60.99156045
55ERBB20.97950838
56ERBB30.96987360
57EEF2K0.96974253
58MAPK150.95441722
59MAPK40.94228367
60PRKCI0.92280944
61ACVR1B0.91160010
62CAMK1D0.90209561
63MET0.89852005
64PRKCZ0.89474680
65WEE10.88910084
66STK30.88180125
67LMTK20.85775350
68CDK120.85520470
69CDK60.85464450
70MYLK0.84459098
71NEK60.83719436
72BMPR1B0.83569386
73PDK20.82786035
74EPHB10.82095754
75TGFBR20.80645235
76WNK40.77263447
77IRAK30.77235012
78RIPK10.76786225
79MAPK120.76287961
80EPHA30.75668414
81MAP3K100.75484038
82CSK0.75357971
83PRKACG0.73760456
84MAP3K110.73724974
85PHKG20.71715187
86PHKG10.71715187
87GSK3A0.70946757
88AKT20.70473463
89EIF2AK10.70014237
90SGK30.69755252
91MAP2K60.69451098
92CAMK2G0.68265433
93FER0.67055143
94DYRK1B0.66542694
95PRKAA10.64951413
96BRSK20.62172891
97FGFR30.61770802
98GRK10.60867664
99MAP3K40.58395639
100PTK20.58065875
101MAPK70.57230363
102AURKA0.55435169
103TRIM280.55116103
104IKBKE0.55073479
105AKT30.52543281
106PDPK10.52464748
107SGK20.52424686
108TAOK20.51722485
109CSF1R0.51709022
110PRKCE0.50128486
111MAP2K10.49240299
112PRKCQ0.48409636
113IGF1R0.47997779
114DMPK0.47692091
115CSNK1G10.47614371
116ADRBK10.45467074
117TAOK10.44467490
118ROCK20.44356832
119PBK0.44277030
120EIF2AK30.43972200
121PRKACA0.43085148
122NTRK30.42863648
123PDK30.42229163
124PDK40.42229163
125ILK0.41883838
126MAP3K50.41743070
127STK380.41545055
128TGFBR10.39677050
129SMG10.39647475
130WNK30.39514816
131SGK2230.38974241
132SGK4940.38974241
133PRKCD0.37894463
134CAMK1G0.35331505
135RET0.35183822
136CDK40.34390522
137EGFR0.34289462
138PRKCG0.32853332
139MTOR0.32573296
140EPHA40.32324268
141MAP3K60.31584707
142MAP2K20.30559184
143ADRBK20.30335638
144CHUK0.30105784
145CAMK40.29919935
146NLK0.29750051
147SGK10.29414494
148PDK10.28958522
149PKN10.28735761
150MAP3K130.27483100
151CSNK1G20.26715771
152PRKCA0.26050068
153PLK20.25712059
154PIK3CA0.25266381
155ABL10.25203128
156PAK30.25101486
157ICK0.24931106
158EPHA20.24785207
159MAP3K20.24739466
160IRAK10.24283641
161DYRK1A0.23600352
162CSNK1G30.23461712
163BMPR20.22037830
164CAMK2A0.20893744
165MELK0.20344211
166RPS6KA50.20286847
167MARK30.19991704

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.45092294
2Nitrogen metabolism_Homo sapiens_hsa009103.52185491
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44326552
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29663905
5Arginine biosynthesis_Homo sapiens_hsa002203.00885807
6Huntingtons disease_Homo sapiens_hsa050162.94693786
7Tryptophan metabolism_Homo sapiens_hsa003802.70358342
8Complement and coagulation cascades_Homo sapiens_hsa046102.68404459
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68367477
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58828397
11Fatty acid degradation_Homo sapiens_hsa000712.49978834
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49462661
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40106328
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34982844
15* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.19350102
16Butanoate metabolism_Homo sapiens_hsa006502.14110691
17Peroxisome_Homo sapiens_hsa041462.08502202
18* Chemical carcinogenesis_Homo sapiens_hsa052041.98870266
19* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.98478059
20Propanoate metabolism_Homo sapiens_hsa006401.97713420
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.97413726
22Histidine metabolism_Homo sapiens_hsa003401.92463148
23PPAR signaling pathway_Homo sapiens_hsa033201.87234300
24Fatty acid metabolism_Homo sapiens_hsa012121.81697416
25Caffeine metabolism_Homo sapiens_hsa002321.81398951
26Retinol metabolism_Homo sapiens_hsa008301.79521875
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.78705022
28beta-Alanine metabolism_Homo sapiens_hsa004101.75778836
29Staphylococcus aureus infection_Homo sapiens_hsa051501.70508301
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70006190
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66556704
32Phenylalanine metabolism_Homo sapiens_hsa003601.60458696
33Selenocompound metabolism_Homo sapiens_hsa004501.59596428
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56047350
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51280718
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49573348
37Sphingolipid metabolism_Homo sapiens_hsa006001.47452232
38Bile secretion_Homo sapiens_hsa049761.47223321
39Tyrosine metabolism_Homo sapiens_hsa003501.46945269
40Sulfur metabolism_Homo sapiens_hsa009201.41598466
41Pyruvate metabolism_Homo sapiens_hsa006201.38378684
42Fatty acid elongation_Homo sapiens_hsa000621.33244751
43Starch and sucrose metabolism_Homo sapiens_hsa005001.30926810
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.30454338
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26780345
46Oxidative phosphorylation_Homo sapiens_hsa001901.24538852
47Steroid biosynthesis_Homo sapiens_hsa001001.22476760
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21185742
49Folate biosynthesis_Homo sapiens_hsa007901.19439796
50ABC transporters_Homo sapiens_hsa020101.18212690
51Biosynthesis of amino acids_Homo sapiens_hsa012301.17879890
52Fat digestion and absorption_Homo sapiens_hsa049751.14126196
53Carbon metabolism_Homo sapiens_hsa012001.12847153
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08708289
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07155928
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06223382
57Circadian rhythm_Homo sapiens_hsa047101.05316332
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02430634
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01597160
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99952303
61Tight junction_Homo sapiens_hsa045300.99232862
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.98070564
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.97369381
64Arginine and proline metabolism_Homo sapiens_hsa003300.95906070
65Sulfur relay system_Homo sapiens_hsa041220.95773786
66Parkinsons disease_Homo sapiens_hsa050120.93619880
67Vitamin B6 metabolism_Homo sapiens_hsa007500.93378185
68Collecting duct acid secretion_Homo sapiens_hsa049660.92833010
69Pancreatic secretion_Homo sapiens_hsa049720.91900868
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87173637
71Vitamin digestion and absorption_Homo sapiens_hsa049770.85764316
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83352628
73Lysine degradation_Homo sapiens_hsa003100.79800170
74Alzheimers disease_Homo sapiens_hsa050100.79441320
75Mineral absorption_Homo sapiens_hsa049780.74819595
76One carbon pool by folate_Homo sapiens_hsa006700.73786469
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73107408
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72782438
79Glycerolipid metabolism_Homo sapiens_hsa005610.70313697
80Salivary secretion_Homo sapiens_hsa049700.67177297
81* Glutathione metabolism_Homo sapiens_hsa004800.63482514
82Fatty acid biosynthesis_Homo sapiens_hsa000610.60280637
83Pentose phosphate pathway_Homo sapiens_hsa000300.59086971
84Hedgehog signaling pathway_Homo sapiens_hsa043400.55031829
85Protein digestion and absorption_Homo sapiens_hsa049740.53444508
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49326446
87Metabolic pathways_Homo sapiens_hsa011000.46089430
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39176028
89Phototransduction_Homo sapiens_hsa047440.37732223
90Lysosome_Homo sapiens_hsa041420.36473222
91Vibrio cholerae infection_Homo sapiens_hsa051100.34630416
92TGF-beta signaling pathway_Homo sapiens_hsa043500.34205491
93Prion diseases_Homo sapiens_hsa050200.32818125
94Protein export_Homo sapiens_hsa030600.31306581
95Galactose metabolism_Homo sapiens_hsa000520.25730930
96Ether lipid metabolism_Homo sapiens_hsa005650.25709318
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25164112
98Fructose and mannose metabolism_Homo sapiens_hsa000510.24645835
99Serotonergic synapse_Homo sapiens_hsa047260.23890712
100Linoleic acid metabolism_Homo sapiens_hsa005910.22299100
101Insulin resistance_Homo sapiens_hsa049310.21927453
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.21521256
103N-Glycan biosynthesis_Homo sapiens_hsa005100.21392775
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18540346
105Hippo signaling pathway_Homo sapiens_hsa043900.18413894
106Notch signaling pathway_Homo sapiens_hsa043300.17041013
107Cardiac muscle contraction_Homo sapiens_hsa042600.16494928
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.14938210
109Glucagon signaling pathway_Homo sapiens_hsa049220.08125008
110AMPK signaling pathway_Homo sapiens_hsa041520.01906828
111Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2439397
112Pertussis_Homo sapiens_hsa05133-0.2435716
113Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2399272
114Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2355496
115Amoebiasis_Homo sapiens_hsa05146-0.2352973
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2266827
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2014549
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1928047
119Renin-angiotensin system_Homo sapiens_hsa04614-0.1757470
120Hepatitis C_Homo sapiens_hsa05160-0.1706621
121Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1683892
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1656232
123Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1469773
124African trypanosomiasis_Homo sapiens_hsa05143-0.1388716
125Regulation of autophagy_Homo sapiens_hsa04140-0.1385211
126Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1282516
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1121044
128Insulin signaling pathway_Homo sapiens_hsa04910-0.1038412
129Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0664550
130Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0638618
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0454591

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