GSTA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.56778890
2nucleobase catabolic process (GO:0046113)5.33305317
3regulation of gene silencing by RNA (GO:0060966)5.14811251
4regulation of posttranscriptional gene silencing (GO:0060147)5.14811251
5regulation of gene silencing by miRNA (GO:0060964)5.14811251
6presynaptic membrane assembly (GO:0097105)4.85812949
7neuron cell-cell adhesion (GO:0007158)4.68824383
8ethanol oxidation (GO:0006069)4.47033096
9presynaptic membrane organization (GO:0097090)4.46581742
10postsynaptic membrane organization (GO:0001941)4.21475717
11axonal fasciculation (GO:0007413)4.09410894
12xenobiotic catabolic process (GO:0042178)3.95915696
13vocalization behavior (GO:0071625)3.92810398
14establishment of mitochondrion localization (GO:0051654)3.91626052
15response to nitrosative stress (GO:0051409)3.88928870
16gamma-aminobutyric acid transport (GO:0015812)3.85158228
17formation of translation preinitiation complex (GO:0001731)3.83210375
18neuron recognition (GO:0008038)3.81542708
19sequestering of actin monomers (GO:0042989)3.78029114
20L-ascorbic acid metabolic process (GO:0019852)3.70801065
21protein localization to synapse (GO:0035418)3.70540908
22nucleobase biosynthetic process (GO:0046112)3.70060390
23positive regulation of mitochondrial fission (GO:0090141)3.68991384
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64512369
25anterior/posterior axis specification, embryo (GO:0008595)3.64183528
26negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.61749334
27purine nucleobase biosynthetic process (GO:0009113)3.61642429
28folic acid-containing compound biosynthetic process (GO:0009396)3.57518337
29glycine metabolic process (GO:0006544)3.55829360
30neurotransmitter-gated ion channel clustering (GO:0072578)3.54345813
31dendritic spine morphogenesis (GO:0060997)3.53204567
32chaperone-mediated protein complex assembly (GO:0051131)3.52976104
33retinal ganglion cell axon guidance (GO:0031290)3.52889240
34synapse assembly (GO:0007416)3.52829954
35establishment of apical/basal cell polarity (GO:0035089)3.52224353
36paraxial mesoderm development (GO:0048339)3.49969965
37nonmotile primary cilium assembly (GO:0035058)3.49528458
38calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.43198785
39protein localization to cilium (GO:0061512)3.42381287
40primary alcohol catabolic process (GO:0034310)3.40607962
41ribosome assembly (GO:0042255)3.38833573
42behavioral response to nicotine (GO:0035095)3.38769990
43DNA replication-dependent nucleosome assembly (GO:0006335)3.35824819
44DNA replication-dependent nucleosome organization (GO:0034723)3.35824819
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.34273048
46mitotic metaphase plate congression (GO:0007080)3.32914618
47limb bud formation (GO:0060174)3.31937336
48sulfur amino acid catabolic process (GO:0000098)3.26991200
49nuclear pore organization (GO:0006999)3.25929148
50positive regulation of SMAD protein import into nucleus (GO:0060391)3.25000397
51regulation of helicase activity (GO:0051095)3.24536826
52ionotropic glutamate receptor signaling pathway (GO:0035235)3.23496967
53neuronal action potential propagation (GO:0019227)3.22401838
54ethanol metabolic process (GO:0006067)3.22159295
55DNA replication initiation (GO:0006270)3.19477703
56somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17377703
57somatic hypermutation of immunoglobulin genes (GO:0016446)3.17377703
58cell migration in hindbrain (GO:0021535)3.15896753
59IMP biosynthetic process (GO:0006188)3.15579336
60maturation of SSU-rRNA (GO:0030490)3.13174665
61auditory behavior (GO:0031223)3.10172074
62folic acid metabolic process (GO:0046655)3.07802804
63glycosphingolipid biosynthetic process (GO:0006688)3.06685503
64positive regulation of synapse assembly (GO:0051965)3.04977531
65central nervous system projection neuron axonogenesis (GO:0021952)3.04930104
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04481583
67synaptic transmission, glutamatergic (GO:0035249)3.04065660
68establishment of integrated proviral latency (GO:0075713)3.03596365
69regulation of synapse structural plasticity (GO:0051823)3.03020208
70hippocampus development (GO:0021766)3.00990815
71serine family amino acid biosynthetic process (GO:0009070)2.99754718
72serine family amino acid metabolic process (GO:0009069)2.97893820
73DNA unwinding involved in DNA replication (GO:0006268)2.96951657
74cerebral cortex radially oriented cell migration (GO:0021799)2.96266739
75synaptic vesicle maturation (GO:0016188)2.96056608
76ribosome biogenesis (GO:0042254)2.96034728
77regulation of hippo signaling (GO:0035330)2.94650761
78cysteine metabolic process (GO:0006534)2.94440525
79* glutathione derivative biosynthetic process (GO:1901687)2.94435180
80* glutathione derivative metabolic process (GO:1901685)2.94435180
81glutamate receptor signaling pathway (GO:0007215)2.94401763
82intraciliary transport (GO:0042073)2.93923434
83regulation of translational fidelity (GO:0006450)2.92393497
84neural tube formation (GO:0001841)2.92357609
85serine family amino acid catabolic process (GO:0009071)2.92121866
86epithelial cilium movement (GO:0003351)2.90172335
87G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90112285
88nuclear pore complex assembly (GO:0051292)2.89361474
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.89361281
90transmission of nerve impulse (GO:0019226)2.88393196
91establishment of monopolar cell polarity (GO:0061162)2.86701698
92establishment or maintenance of monopolar cell polarity (GO:0061339)2.86701698
93regulation of feeding behavior (GO:0060259)2.85769665
94head development (GO:0060322)2.84975721
95regulation of development, heterochronic (GO:0040034)2.84902223
96bundle of His cell to Purkinje myocyte communication (GO:0086069)2.84574692
97somite development (GO:0061053)2.84055139
98regulation of short-term neuronal synaptic plasticity (GO:0048172)2.83968106
99synaptic vesicle exocytosis (GO:0016079)2.83299792
100IMP metabolic process (GO:0046040)2.82789246
101oxidative phosphorylation (GO:0006119)2.77317397
102tetrahydrofolate metabolic process (GO:0046653)2.76514376
103mitotic nuclear envelope disassembly (GO:0007077)2.74943163
104protein localization to kinetochore (GO:0034501)2.74652894
105olfactory bulb development (GO:0021772)2.73598446
106ribonucleoprotein complex biogenesis (GO:0022613)2.73073678
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72644350
108regulation of SMAD protein import into nucleus (GO:0060390)2.72194839
109gap junction assembly (GO:0016264)2.72022310
110metaphase plate congression (GO:0051310)2.71224153
111aldehyde catabolic process (GO:0046185)2.70135953
112negative regulation of androgen receptor signaling pathway (GO:0060766)2.70078689
113positive regulation of amino acid transport (GO:0051957)2.69314642
114neuron fate determination (GO:0048664)2.68600117
115neuron-neuron synaptic transmission (GO:0007270)2.68258388
116dendrite morphogenesis (GO:0048813)2.67955121
117C4-dicarboxylate transport (GO:0015740)2.67832685
118synapse organization (GO:0050808)2.66783829
119L-serine metabolic process (GO:0006563)2.66713701
120ribosomal small subunit biogenesis (GO:0042274)2.65719122
121one-carbon compound transport (GO:0019755)2.63734404
122neurofilament cytoskeleton organization (GO:0060052)2.62398777
123intestinal epithelial cell development (GO:0060576)2.62383685
124neuronal ion channel clustering (GO:0045161)2.61157220
125protein polyglutamylation (GO:0018095)2.60277208
126mitochondrion transport along microtubule (GO:0047497)2.59443431
127establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.59443431
128regulation of synaptic vesicle exocytosis (GO:2000300)2.59358733
129mechanosensory behavior (GO:0007638)2.59313949
130DNA strand elongation involved in DNA replication (GO:0006271)2.58170318
131cellular glucuronidation (GO:0052695)2.58021177
132positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.57989642
133response to auditory stimulus (GO:0010996)2.57917023
134central nervous system neuron axonogenesis (GO:0021955)2.56929481
135histone arginine methylation (GO:0034969)2.56708183
136notochord development (GO:0030903)2.56606834
137startle response (GO:0001964)2.56118476
138nodal signaling pathway (GO:0038092)2.55580946
139regulation of dendritic spine morphogenesis (GO:0061001)2.55233866
140regulation of timing of cell differentiation (GO:0048505)2.54913989
141determination of adult lifespan (GO:0008340)2.54737394
142regulation of action potential (GO:0098900)2.53981702
143sympathetic nervous system development (GO:0048485)2.53809092
144positive regulation of action potential (GO:0045760)2.52941230
145heterochromatin organization (GO:0070828)2.52609672
146negative regulation of axon extension (GO:0030517)2.51503420
147regulation of respiratory system process (GO:0044065)2.51284329
148negative regulation of axon guidance (GO:1902668)2.51064651
149glial cell proliferation (GO:0014009)2.50785145
150mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.50455819
151cellular aldehyde metabolic process (GO:0006081)2.50369073
152glyoxylate metabolic process (GO:0046487)2.50236882
153regulation of synaptic transmission, glutamatergic (GO:0051966)2.50023109
154nuclear envelope disassembly (GO:0051081)2.49976583
155membrane disassembly (GO:0030397)2.49976583
156negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.49816762
157homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.49748479
158glutamate secretion (GO:0014047)2.49723157
159neuromuscular synaptic transmission (GO:0007274)2.48939353
160interferon-gamma secretion (GO:0072643)2.48841979
161behavioral response to ethanol (GO:0048149)2.46988437
162axon extension (GO:0048675)2.46906294
163ribosomal large subunit biogenesis (GO:0042273)2.46900044
164cilium morphogenesis (GO:0060271)2.46147617
165cornea development in camera-type eye (GO:0061303)2.46095495
166forebrain neuron differentiation (GO:0021879)2.45943707
167neurotransmitter secretion (GO:0007269)2.45703975
168tachykinin receptor signaling pathway (GO:0007217)2.45702353
169DNA replication checkpoint (GO:0000076)2.45533989
170mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.45264860
171positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.45264860
172layer formation in cerebral cortex (GO:0021819)2.43729368
173cytoskeleton-dependent intracellular transport (GO:0030705)2.43681734
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.43354701
175spinal cord development (GO:0021510)2.42639608
176cilium assembly (GO:0042384)2.42621282
177uronic acid metabolic process (GO:0006063)2.42580356
178glucuronate metabolic process (GO:0019585)2.42580356
179adult walking behavior (GO:0007628)2.41497049
180regulation of collateral sprouting (GO:0048670)2.41368417
181DNA strand elongation (GO:0022616)2.38736965
182pteridine-containing compound biosynthetic process (GO:0042559)2.37912725
183rRNA modification (GO:0000154)2.36006166
184pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.35762052
185DNA geometric change (GO:0032392)2.35601217
186proline biosynthetic process (GO:0006561)2.34740915
187regulation of gene silencing (GO:0060968)2.34373961
188folic acid-containing compound metabolic process (GO:0006760)2.34039211
189DNA duplex unwinding (GO:0032508)2.33157899
190flavonoid metabolic process (GO:0009812)2.32023023
191epoxygenase P450 pathway (GO:0019373)2.31894289
192tRNA aminoacylation for protein translation (GO:0006418)2.31585929
193regulation of centrosome cycle (GO:0046605)2.31056663
194blastocyst development (GO:0001824)2.30479313
195cullin deneddylation (GO:0010388)2.29271635
196imidazole-containing compound metabolic process (GO:0052803)2.27674277
197translational initiation (GO:0006413)2.27002659
198regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.26620407
199UMP biosynthetic process (GO:0006222)2.26552277

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.32513532
2EZH2_22144423_ChIP-Seq_EOC_Human4.20375981
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.72691254
4GBX2_23144817_ChIP-Seq_PC3_Human3.46253899
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.41710623
6* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.32836012
7ESR1_15608294_ChIP-ChIP_MCF-7_Human3.25270733
8IGF1R_20145208_ChIP-Seq_DFB_Human3.24427299
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.17637850
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.17637850
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.17637850
12* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.99684426
13ZNF274_21170338_ChIP-Seq_K562_Hela2.92646391
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88804775
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.86066910
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.79707517
17* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.76585214
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.76116554
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73764260
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.71279524
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52166561
22TAF15_26573619_Chip-Seq_HEK293_Human2.51917118
23STAT3_1855785_ChIP-Seq_MESCs_Mouse2.50386440
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.46407555
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40068062
26* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.36764943
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36275378
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35225314
29CBX2_27304074_Chip-Seq_ESCs_Mouse2.33193955
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.29469507
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.26922664
32FUS_26573619_Chip-Seq_HEK293_Human2.21153296
33* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20572034
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19650007
35AR_21909140_ChIP-Seq_LNCAP_Human2.19311625
36E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16527370
37* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.15182272
38TCF3_18692474_ChIP-Seq_MESCs_Mouse2.12613655
39NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10534344
40* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07779812
41* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.07323724
42TP63_17297297_ChIP-ChIP_HaCaT_Human2.06088122
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05388827
44CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04718316
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.04204977
46* SOX2_18555785_ChIP-Seq_MESCs_Mouse2.03783213
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03625332
48VDR_22108803_ChIP-Seq_LS180_Human2.01385263
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.00770094
50REST_21632747_ChIP-Seq_MESCs_Mouse1.97705283
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97164535
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.97157546
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96718360
54RNF2_27304074_Chip-Seq_NSC_Mouse1.96580147
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95577327
56KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.92957180
57P300_19829295_ChIP-Seq_ESCs_Human1.90378073
58* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.90256729
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89439237
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.88944486
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86784939
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.82019573
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80109261
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79939638
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76833222
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.76656476
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74859899
68EWS_26573619_Chip-Seq_HEK293_Human1.74775262
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74480144
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.74479238
71* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.74025748
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73791868
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73791146
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.73351211
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72747199
76* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.71574551
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.69208165
78ETS1_20019798_ChIP-Seq_JURKAT_Human1.68514812
79* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67498537
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65204952
81* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.64806999
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64081158
83HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64005143
84SMAD4_21799915_ChIP-Seq_A2780_Human1.63592356
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60354916
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59629693
87* XRN2_22483619_ChIP-Seq_HELA_Human1.57967514
88ZNF263_19887448_ChIP-Seq_K562_Human1.57393755
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54691785
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53137477
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.52624839
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52610679
93* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.52269822
94* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51575438
95PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50637134
96RXR_22158963_ChIP-Seq_LIVER_Mouse1.45680010
97POU5F1_16518401_ChIP-PET_MESCs_Mouse1.44922623
98* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.44791079
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44563152
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44173836
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43835176
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43539894
103MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43500566
104* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43382991
105HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42548748
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41875700
107GABP_17652178_ChIP-ChIP_JURKAT_Human1.41391824
108SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40051182
109* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.39280799
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39007237
111HIF1A_21447827_ChIP-Seq_MCF-7_Human1.38587424
112AR_25329375_ChIP-Seq_VCAP_Human1.36945958
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.36905763
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.36837386
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36751011
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36462090
117* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.35770622
118POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35227105
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34448361
120CBP_20019798_ChIP-Seq_JUKART_Human1.34448361
121FLI1_27457419_Chip-Seq_LIVER_Mouse1.33884750
122* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33085001
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33079130
124TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33079130
125JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32117280
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29653243
127* EZH2_27294783_Chip-Seq_ESCs_Mouse1.28742400
128EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27095618
129RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26015376
130YY1_21170310_ChIP-Seq_MESCs_Mouse1.25976840
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25944969
132ER_23166858_ChIP-Seq_MCF-7_Human1.24707733
133SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24670757
134PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23779276
135STAT3_23295773_ChIP-Seq_U87_Human1.23713968
136EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22678263
137RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22678263
138PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21827575
139DCP1A_22483619_ChIP-Seq_HELA_Human1.21613389
140SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21324051
141* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.20931821
142AR_21572438_ChIP-Seq_LNCaP_Human1.20649226
143NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19250867
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16507268
145NANOG_16518401_ChIP-PET_MESCs_Mouse1.16087895
146KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16066373
147* NANOG_21062744_ChIP-ChIP_HESCs_Human1.15503151
148NANOG_18555785_Chip-Seq_ESCs_Mouse1.15063143
149CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14726595
150KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14325324
151* RUNX2_22187159_ChIP-Seq_PCA_Human1.13532959
152IRF1_19129219_ChIP-ChIP_H3396_Human1.12979880
153RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12958171
154TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12932976
155* TAL1_26923725_Chip-Seq_HPCs_Mouse1.12311983
156TCF4_23295773_ChIP-Seq_U87_Human1.11015854
157E2F1_21310950_ChIP-Seq_MCF-7_Human1.10750721
158SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10733923
159SOX2_21211035_ChIP-Seq_LN229_Gbm1.10668624
160* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10480805
161BCAT_22108803_ChIP-Seq_LS180_Human1.08397877
162EGR1_19374776_ChIP-ChIP_THP-1_Human1.08149959
163EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07917760
164SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07325431
165* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07031841
166ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06719800
167* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06388563
168CLOCK_20551151_ChIP-Seq_293T_Human1.06268973
169RNF2_27304074_Chip-Seq_ESCs_Mouse1.06134331
170SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05926193
171CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04426862
172ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03312883
173* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03227949
174NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03203425
175TP53_22573176_ChIP-Seq_HFKS_Human1.02876201
176KAP1_27257070_Chip-Seq_ESCs_Mouse1.02118584
177TTF2_22483619_ChIP-Seq_HELA_Human1.02014664
178GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01641964
179SOX9_26525672_Chip-Seq_HEART_Mouse1.01321510
180LXR_22158963_ChIP-Seq_LIVER_Mouse1.00606802
181CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98702351
182TCF4_22108803_ChIP-Seq_LS180_Human0.98694322
183PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98095781
184EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97649092
185SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97564729
186MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96728326
187SOX2_16153702_ChIP-ChIP_HESCs_Human0.96522035
188P53_22387025_ChIP-Seq_ESCs_Mouse0.96328026
189* JUN_21703547_ChIP-Seq_K562_Human0.95156176
190* SOX17_20123909_ChIP-Seq_XEN_Mouse0.94211405
191TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93950903
192STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93671349
193ESR1_21235772_ChIP-Seq_MCF-7_Human0.92187438
194GABP_19822575_ChIP-Seq_HepG2_Human0.91144430
195* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90795697
196THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88889349

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.43921916
2MP0008004_abnormal_stomach_pH3.81053182
3MP0003880_abnormal_central_pattern3.52980413
4MP0001529_abnormal_vocalization3.13971668
5MP0003122_maternal_imprinting3.07201633
6MP0008875_abnormal_xenobiotic_pharmacok3.03281908
7MP0002822_catalepsy3.02713644
8MP0002139_abnormal_hepatobiliary_system2.88691985
9MP0004270_analgesia2.86407164
10MP0004957_abnormal_blastocyst_morpholog2.81322575
11MP0004859_abnormal_synaptic_plasticity2.67664575
12MP0005085_abnormal_gallbladder_physiolo2.59064178
13MP0003693_abnormal_embryo_hatching2.54867421
14MP0000778_abnormal_nervous_system2.52861372
15MP0001984_abnormal_olfaction2.44964851
16MP0006276_abnormal_autonomic_nervous2.32587809
17MP0004133_heterotaxia2.29730235
18MP0002102_abnormal_ear_morphology2.28455666
19MP0005423_abnormal_somatic_nervous2.27210324
20MP0005360_urolithiasis2.19621566
21MP0010030_abnormal_orbit_morphology2.18950518
22MP0010234_abnormal_vibrissa_follicle2.18065464
23MP0000537_abnormal_urethra_morphology2.16473515
24MP0003635_abnormal_synaptic_transmissio2.10363959
25MP0002653_abnormal_ependyma_morphology2.09569066
26MP0010352_gastrointestinal_tract_polyps2.07790336
27MP0003787_abnormal_imprinting2.07307903
28MP0003121_genomic_imprinting2.05460226
29MP0001968_abnormal_touch/_nociception2.02904018
30MP0010094_abnormal_chromosome_stability2.00830208
31MP0009745_abnormal_behavioral_response1.96076101
32MP0009046_muscle_twitch1.93983085
33MP0003111_abnormal_nucleus_morphology1.93980773
34MP0002736_abnormal_nociception_after1.93504211
35MP0002734_abnormal_mechanical_nocicepti1.93286375
36MP0003941_abnormal_skin_development1.91903679
37MP0003705_abnormal_hypodermis_morpholog1.91637951
38MP0005365_abnormal_bile_salt1.87253835
39MP0002272_abnormal_nervous_system1.85535849
40MP0002735_abnormal_chemical_nociception1.84667864
41MP0000516_abnormal_urinary_system1.82623015
42MP0005367_renal/urinary_system_phenotyp1.82623015
43MP0003077_abnormal_cell_cycle1.82138800
44MP0002063_abnormal_learning/memory/cond1.81897989
45MP0003123_paternal_imprinting1.81701886
46MP0005645_abnormal_hypothalamus_physiol1.77578542
47MP0002572_abnormal_emotion/affect_behav1.74098791
48* MP0003186_abnormal_redox_activity1.73473905
49MP0001486_abnormal_startle_reflex1.70905481
50MP0003119_abnormal_digestive_system1.70398261
51MP0001730_embryonic_growth_arrest1.67614624
52MP0004264_abnormal_extraembryonic_tissu1.67169416
53MP0003718_maternal_effect1.67071949
54MP0002064_seizures1.66989613
55MP0001188_hyperpigmentation1.63130938
56MP0009053_abnormal_anal_canal1.59551241
57MP0002557_abnormal_social/conspecific_i1.58001548
58MP0008057_abnormal_DNA_replication1.57713539
59MP0003136_yellow_coat_color1.55958346
60MP0006072_abnormal_retinal_apoptosis1.51953243
61MP0003890_abnormal_embryonic-extraembry1.48470412
62MP0002751_abnormal_autonomic_nervous1.46261123
63MP0000631_abnormal_neuroendocrine_gland1.45715775
64MP0000955_abnormal_spinal_cord1.45578419
65MP0004019_abnormal_vitamin_homeostasis1.44266083
66MP0004142_abnormal_muscle_tone1.43526745
67MP0002909_abnormal_adrenal_gland1.42247205
68MP0002184_abnormal_innervation1.41378701
69MP0005551_abnormal_eye_electrophysiolog1.41305981
70MP0002638_abnormal_pupillary_reflex1.39657602
71MP0008877_abnormal_DNA_methylation1.38915229
72MP0002796_impaired_skin_barrier1.38622551
73MP0008058_abnormal_DNA_repair1.38335464
74MP0003786_premature_aging1.37458332
75MP0005253_abnormal_eye_physiology1.37410830
76MP0005386_behavior/neurological_phenoty1.37180667
77MP0004924_abnormal_behavior1.37180667
78MP0005083_abnormal_biliary_tract1.36806326
79MP0000049_abnormal_middle_ear1.35302976
80MP0004811_abnormal_neuron_physiology1.34556544
81MP0005380_embryogenesis_phenotype1.34267831
82MP0001672_abnormal_embryogenesis/_devel1.34267831
83MP0002067_abnormal_sensory_capabilities1.32623267
84MP0001970_abnormal_pain_threshold1.32447059
85* MP0005266_abnormal_metabolism1.31617315
86MP0000350_abnormal_cell_proliferation1.30774824
87MP0003566_abnormal_cell_adhesion1.30592018
88MP0002882_abnormal_neuron_morphology1.30207570
89MP0005332_abnormal_amino_acid1.30015391
90MP0003283_abnormal_digestive_organ1.29922435
91MP0008932_abnormal_embryonic_tissue1.29685825
92MP0002234_abnormal_pharynx_morphology1.28890271
93MP0005248_abnormal_Harderian_gland1.27467499
94MP0001849_ear_inflammation1.27294246
95MP0002085_abnormal_embryonic_tissue1.26738636
96MP0002084_abnormal_developmental_patter1.24838257
97MP0004885_abnormal_endolymph1.22934628
98MP0003011_delayed_dark_adaptation1.22155734
99MP0006292_abnormal_olfactory_placode1.20659060
100MP0000470_abnormal_stomach_morphology1.19829745
101MP0000762_abnormal_tongue_morphology1.19082486
102MP0002733_abnormal_thermal_nociception1.18673118
103MP0002938_white_spotting1.16776867
104MP0001293_anophthalmia1.15505442
105MP0000647_abnormal_sebaceous_gland1.15229969
106MP0000569_abnormal_digit_pigmentation1.14971024
107MP0003984_embryonic_growth_retardation1.13634836
108MP0002086_abnormal_extraembryonic_tissu1.13149345
109MP0002752_abnormal_somatic_nervous1.12798669
110MP0000566_synostosis1.12760431
111MP0001905_abnormal_dopamine_level1.11879037
112MP0002088_abnormal_embryonic_growth/wei1.11647578
113MP0010329_abnormal_lipoprotein_level1.08860735
114MP0004197_abnormal_fetal_growth/weight/1.08450233
115MP0001697_abnormal_embryo_size1.07956862
116MP0002254_reproductive_system_inflammat1.05426149
117MP0002152_abnormal_brain_morphology1.05011227
118MP0005646_abnormal_pituitary_gland1.04713866
119MP0000467_abnormal_esophagus_morphology1.04641297
120MP0000026_abnormal_inner_ear1.03907588
121MP0008007_abnormal_cellular_replicative1.03020687
122MP0003315_abnormal_perineum_morphology1.02708942
123MP0005501_abnormal_skin_physiology1.02307393
124MP0002080_prenatal_lethality1.01982405
125MP0004742_abnormal_vestibular_system1.01209892
126MP0002837_dystrophic_cardiac_calcinosis1.00200650
127MP0001502_abnormal_circadian_rhythm0.99440820
128MP0005377_hearing/vestibular/ear_phenot0.98510413
129MP0003878_abnormal_ear_physiology0.98510413
130MP0002066_abnormal_motor_capabilities/c0.97541224
131MP0009379_abnormal_foot_pigmentation0.97006152
132MP0003861_abnormal_nervous_system0.96003478
133MP0002249_abnormal_larynx_morphology0.95411025
134MP0008789_abnormal_olfactory_epithelium0.93768945
135MP0001666_abnormal_nutrient_absorption0.92133115
136MP0003567_abnormal_fetal_cardiomyocyte0.91103206
137MP0003938_abnormal_ear_development0.89277988
138MP0005023_abnormal_wound_healing0.88479335
139MP0001299_abnormal_eye_distance/0.88113568
140MP0002069_abnormal_eating/drinking_beha0.87906824
141MP0005171_absent_coat_pigmentation0.87009217
142MP0010386_abnormal_urinary_bladder0.86936591
143MP0001664_abnormal_digestion0.86630499
144MP0005395_other_phenotype0.86574880
145MP0000751_myopathy0.85269783
146MP0005195_abnormal_posterior_eye0.84691915
147MP0003937_abnormal_limbs/digits/tail_de0.84387170
148MP0002111_abnormal_tail_morphology0.83727326
149MP0003755_abnormal_palate_morphology0.83394849
150MP0001501_abnormal_sleep_pattern0.83223993
151MP0001485_abnormal_pinna_reflex0.82946628
152MP0005408_hypopigmentation0.81598116
153MP0001286_abnormal_eye_development0.81052757
154MP0005499_abnormal_olfactory_system0.80756973
155MP0005394_taste/olfaction_phenotype0.80756973
156MP0003252_abnormal_bile_duct0.80097491
157MP0005391_vision/eye_phenotype0.79517301
158MP0001986_abnormal_taste_sensitivity0.79386829
159MP0009840_abnormal_foam_cell0.78668688
160MP0001963_abnormal_hearing_physiology0.78506278
161MP0001440_abnormal_grooming_behavior0.76957752
162MP0002928_abnormal_bile_duct0.75451296
163MP0000534_abnormal_ureter_morphology0.74746331
164MP0003936_abnormal_reproductive_system0.74550293
165MP0002233_abnormal_nose_morphology0.74309228
166* MP0005376_homeostasis/metabolism_phenot0.73997566
167MP0004233_abnormal_muscle_weight0.72982721
168MP0002229_neurodegeneration0.72063394
169MP0004145_abnormal_muscle_electrophysio0.71121656
170MP0000639_abnormal_adrenal_gland0.71066249
171MP0003115_abnormal_respiratory_system0.70680945
172MP0001145_abnormal_male_reproductive0.70068088
173MP0005084_abnormal_gallbladder_morpholo0.70020115
174MP0002127_abnormal_cardiovascular_syste0.70009291
175MP0002092_abnormal_eye_morphology0.69811237
176MP0003221_abnormal_cardiomyocyte_apopto0.68674626
177MP0002210_abnormal_sex_determination0.68063277
178MP0002269_muscular_atrophy0.67724600
179MP0002160_abnormal_reproductive_system0.67110813
180MP0006036_abnormal_mitochondrial_physio0.65957504
181MP0005187_abnormal_penis_morphology0.65047071
182MP0004084_abnormal_cardiac_muscle0.64913883
183* MP0005319_abnormal_enzyme/_coenzyme0.64856877
184MP0008995_early_reproductive_senescence0.64229600

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)3.98936545
2Ependymoma (HP:0002888)3.76366821
3Gait imbalance (HP:0002141)3.67595016
4Polyphagia (HP:0002591)3.54972085
5Medial flaring of the eyebrow (HP:0010747)3.51546152
6Breast hypoplasia (HP:0003187)3.44514226
7Intrahepatic cholestasis (HP:0001406)3.40641102
8Right ventricular cardiomyopathy (HP:0011663)3.39249380
9Oral leukoplakia (HP:0002745)3.33317742
10Congenital primary aphakia (HP:0007707)3.31156954
11Focal motor seizures (HP:0011153)3.26201806
12Hyperglycinemia (HP:0002154)3.22809884
13Hyperglycinuria (HP:0003108)3.19920960
14Hypobetalipoproteinemia (HP:0003563)3.18578444
15Nephrogenic diabetes insipidus (HP:0009806)3.15018327
16Abnormality of the labia minora (HP:0012880)3.08432747
17Limb dystonia (HP:0002451)3.06374570
18Genital tract atresia (HP:0001827)3.03629916
19Drooling (HP:0002307)3.02498867
20Lissencephaly (HP:0001339)3.00192619
21Abnormality of pyrimidine metabolism (HP:0004353)2.97756836
22Spastic diplegia (HP:0001264)2.96262083
23True hermaphroditism (HP:0010459)2.95940248
24Selective tooth agenesis (HP:0001592)2.95293572
25Vaginal atresia (HP:0000148)2.94390229
26Retinal dysplasia (HP:0007973)2.91122622
27Esophageal atresia (HP:0002032)2.90996210
28Supernumerary spleens (HP:0009799)2.86919822
29Colon cancer (HP:0003003)2.86391138
30Pancreatic fibrosis (HP:0100732)2.83855497
31Hyperventilation (HP:0002883)2.79162180
32Birth length less than 3rd percentile (HP:0003561)2.78762948
33Abnormality of midbrain morphology (HP:0002418)2.77669842
34Molar tooth sign on MRI (HP:0002419)2.77669842
35Myokymia (HP:0002411)2.77199619
36Nephronophthisis (HP:0000090)2.77162812
37Abnormality of glycine metabolism (HP:0010895)2.77141731
38Abnormality of serine family amino acid metabolism (HP:0010894)2.77141731
39Abnormality of abdominal situs (HP:0011620)2.75068075
40Abdominal situs inversus (HP:0003363)2.75068075
41Focal seizures (HP:0007359)2.74296876
42Excessive salivation (HP:0003781)2.72127214
43Pancreatic cysts (HP:0001737)2.66942518
44Cortical dysplasia (HP:0002539)2.66408989
45Multiple enchondromatosis (HP:0005701)2.66386661
46Biliary tract neoplasm (HP:0100574)2.62526123
47Aplasia/hypoplasia of the humerus (HP:0006507)2.61638850
48Rhabdomyosarcoma (HP:0002859)2.60912923
49Stenosis of the external auditory canal (HP:0000402)2.59853239
50Pachygyria (HP:0001302)2.57513865
51Absent speech (HP:0001344)2.55636551
52Absent radius (HP:0003974)2.54340506
53Hyperammonemia (HP:0001987)2.53668695
54Abnormality of the astrocytes (HP:0100707)2.53423094
55Astrocytoma (HP:0009592)2.53423094
56Broad-based gait (HP:0002136)2.50853101
57Aplasia involving forearm bones (HP:0009822)2.45617441
58Absent forearm bone (HP:0003953)2.45617441
59Short humerus (HP:0005792)2.38162132
60Hypolipoproteinemia (HP:0010981)2.38084678
61Malnutrition (HP:0004395)2.37970791
62Split foot (HP:0001839)2.37517967
63Atonic seizures (HP:0010819)2.37347559
64Vaginal fistula (HP:0004320)2.35922020
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.33906443
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.33906443
67Delayed CNS myelination (HP:0002188)2.33058752
68Specific learning disability (HP:0001328)2.31982073
69Lethargy (HP:0001254)2.30651087
70Hypoplasia of the brainstem (HP:0002365)2.29720115
71Aplasia/Hypoplasia of the brainstem (HP:0007362)2.29720115
72Cerebral edema (HP:0002181)2.29481691
73Type II lissencephaly (HP:0007260)2.29321865
74Urinary urgency (HP:0000012)2.28747521
75Postaxial hand polydactyly (HP:0001162)2.28689340
76Amyotrophic lateral sclerosis (HP:0007354)2.26577969
77Medulloblastoma (HP:0002885)2.23627849
78Abnormality of the renal medulla (HP:0100957)2.22947535
79Carpal bone hypoplasia (HP:0001498)2.21170883
80Abnormality of the corticospinal tract (HP:0002492)2.20430628
81Missing ribs (HP:0000921)2.20302634
82Hypsarrhythmia (HP:0002521)2.20048392
83Renal salt wasting (HP:0000127)2.19149187
84Poor coordination (HP:0002370)2.18928635
85Glioma (HP:0009733)2.17338831
86Febrile seizures (HP:0002373)2.16215735
87Chronic hepatic failure (HP:0100626)2.14964835
88Abnormal hemoglobin (HP:0011902)2.14876309
89Poor suck (HP:0002033)2.14582854
90Abnormal eating behavior (HP:0100738)2.14379458
91EEG with generalized epileptiform discharges (HP:0011198)2.13182573
92Abnormality of sulfur amino acid metabolism (HP:0004339)2.13066718
93Acute necrotizing encephalopathy (HP:0006965)2.12702147
94Epileptic encephalopathy (HP:0200134)2.12034061
95Progressive cerebellar ataxia (HP:0002073)2.11253485
96Intestinal atresia (HP:0011100)2.10985628
97Optic nerve hypoplasia (HP:0000609)2.10577930
98Agitation (HP:0000713)2.10509961
99Epileptiform EEG discharges (HP:0011182)2.10064905
100Hepatoblastoma (HP:0002884)2.09810426
101Spastic tetraplegia (HP:0002510)2.09113250
102Decreased testicular size (HP:0008734)2.08768001
103Gout (HP:0001997)2.08637249
104Narrow forehead (HP:0000341)2.07865556
105Hemiparesis (HP:0001269)2.07468408
106Abnormality of the salivary glands (HP:0010286)2.06928126
107Occipital encephalocele (HP:0002085)2.05823568
108Impulsivity (HP:0100710)2.05493100
109Hemivertebrae (HP:0002937)2.05334120
110Dialeptic seizures (HP:0011146)2.05302354
111Inability to walk (HP:0002540)2.04372526
112Thyroid-stimulating hormone excess (HP:0002925)2.03752628
113Megaloblastic anemia (HP:0001889)2.02760691
114Impaired vibration sensation in the lower limbs (HP:0002166)2.02449763
115Anophthalmia (HP:0000528)2.02444560
116Ovarian neoplasm (HP:0100615)2.00630382
117Trismus (HP:0000211)2.00574970
118Agnosia (HP:0010524)1.99728941
119Failure to thrive in infancy (HP:0001531)1.99700657
120Shawl scrotum (HP:0000049)1.99664512
121Broad foot (HP:0001769)1.98700295
122Abnormal biliary tract morphology (HP:0012440)1.98463215
123Hypothermia (HP:0002045)1.98349959
124Aplasia/Hypoplasia of the tibia (HP:0005772)1.98064248
125Angiofibromas (HP:0010615)1.97759729
126Adenoma sebaceum (HP:0009720)1.97759729
127Abnormal cartilage morphology (HP:0002763)1.97405494
128Progressive macrocephaly (HP:0004481)1.97036474
129Fragile nails (HP:0001808)1.96930474
130Postaxial foot polydactyly (HP:0001830)1.96698370
131Abnormality of the hip-girdle musculature (HP:0001445)1.96374535
132Abnormality of the musculature of the pelvis (HP:0001469)1.96374535
133Abnormality of methionine metabolism (HP:0010901)1.95148982
134Pseudobulbar signs (HP:0002200)1.95100713
135Gastrointestinal atresia (HP:0002589)1.94658967
136Shoulder girdle muscle weakness (HP:0003547)1.94532976
137Abnormality of the anterior horn cell (HP:0006802)1.94349580
138Degeneration of anterior horn cells (HP:0002398)1.94349580
139Oligodactyly (hands) (HP:0001180)1.94199518
140Abnormality of glycolysis (HP:0004366)1.94039941
141Increased serum pyruvate (HP:0003542)1.94039941
142Short tibia (HP:0005736)1.93616595
143Premature ovarian failure (HP:0008209)1.93581779
144Generalized tonic-clonic seizures (HP:0002069)1.93112783
145Sex reversal (HP:0012245)1.92649157
146Abnormal sex determination (HP:0012244)1.92649157
147Methylmalonic acidemia (HP:0002912)1.90442533
148Esotropia (HP:0000565)1.90249175
149Tubulointerstitial nephritis (HP:0001970)1.90041560
150Rib fusion (HP:0000902)1.89242850
151Labial hypoplasia (HP:0000066)1.88403558
152Micropenis (HP:0000054)1.86734456
153Abnormality of serum amino acid levels (HP:0003112)1.86675135
154Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86589148
155Distal lower limb muscle weakness (HP:0009053)1.86259691
156Renal cortical cysts (HP:0000803)1.85561255
157Neoplasm of striated muscle (HP:0009728)1.85080087
158Hypoalphalipoproteinemia (HP:0003233)1.84585711
159Onycholysis (HP:0001806)1.84508040
160Progressive inability to walk (HP:0002505)1.84333940
161Back pain (HP:0003418)1.82421692
162Horseshoe kidney (HP:0000085)1.82257844
163Abnormal mitochondria in muscle tissue (HP:0008316)1.81843232
164Scrotal hypoplasia (HP:0000046)1.80543477
165Abnormality of the lower motor neuron (HP:0002366)1.80219670
166Deep venous thrombosis (HP:0002625)1.78770084
167Neoplasm of the rectum (HP:0100743)1.78742865
168Abnormality of nucleobase metabolism (HP:0010932)1.78465849
169Amblyopia (HP:0000646)1.78178978
170Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78043116
171Short foot (HP:0001773)1.77358477
172Aplasia/Hypoplasia of the patella (HP:0006498)1.76973429
173Renal hypoplasia (HP:0000089)1.76743529
174Patellar aplasia (HP:0006443)1.76419228
175Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76303439
176Sclerocornea (HP:0000647)1.76260441
177Aplasia/Hypoplasia of the lens (HP:0008063)1.76115186
178Aplasia/Hypoplasia of the tongue (HP:0010295)1.75764703
179Long foot (HP:0001833)1.75531260
180Atrophy/Degeneration involving motor neurons (HP:0007373)1.75192120
181Exotropia (HP:0000577)1.75052923
182Fused cervical vertebrae (HP:0002949)1.73609402
183Mitochondrial inheritance (HP:0001427)1.73062502
184Abnormality of the labia (HP:0000058)1.72372063
185Facial cleft (HP:0002006)1.71428862
186Abnormality of vitamin metabolism (HP:0100508)1.71240051
187Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70718179
188Anencephaly (HP:0002323)1.70688847
189Abnormality of cells of the erythroid lineage (HP:0012130)1.70055093
190Rimmed vacuoles (HP:0003805)1.69440586
191Rectal fistula (HP:0100590)1.68862678
192Rectovaginal fistula (HP:0000143)1.68862678
193Acute encephalopathy (HP:0006846)1.68491787
194Uterine neoplasm (HP:0010784)1.68271108
195Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.66505395
196Short 1st metacarpal (HP:0010034)1.66505395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.18579569
2MARK14.79221182
3CASK3.76896403
4WEE13.60624028
5MAP3K43.46430572
6BCR3.20879128
7MAP2K73.12415877
8NEK13.08505476
9WNK33.03879578
10BUB12.85590566
11MAP4K22.84166800
12MAPK132.82176123
13RPS6KB22.72947205
14MST42.72448945
15BCKDK2.57334806
16ERBB42.56884367
17TTK2.45416081
18EPHA42.33355491
19TRIM282.32737926
20DYRK22.19636215
21STK38L2.17099328
22PNCK2.17093947
23CSNK1G22.03227040
24CDC71.97907769
25PDK31.95301320
26PDK41.95301320
27PAK41.91504656
28CSNK1G31.90262337
29PINK11.87687271
30CSNK1A1L1.78252475
31NTRK21.73297856
32CDK121.73255150
33PDK21.72985809
34TNIK1.71545251
35MST1R1.64437589
36MET1.60925231
37CSNK1G11.60343822
38TSSK61.56925704
39LATS21.55270922
40PLK11.52276432
41MAP2K41.52052522
42UHMK11.49323377
43CDK71.47989101
44MAPKAPK31.46911860
45EIF2AK11.43968440
46AKT31.43818034
47SIK21.41884932
48MINK11.40251712
49PAK31.38567461
50LATS11.35182039
51PLK31.32913392
52PRKCI1.27100382
53EPHA31.27005690
54PBK1.26246215
55TESK11.23629588
56MYLK1.19271698
57CDK191.18897736
58AURKB1.18503214
59FER1.17433909
60MAP3K81.16678095
61PRKCG1.16644276
62NTRK31.16228945
63AURKA1.13492439
64PKN21.12523005
65ZAK1.10335943
66PLK21.09215120
67STK101.05872698
68NEK21.04330671
69SRPK11.03291254
70PRKCE1.00035385
71MAP3K30.99183477
72RPS6KA40.97887280
73DYRK1A0.94885712
74PHKG20.94025172
75PHKG10.94025172
76PAK60.93731260
77PASK0.93465471
78CDK50.92554642
79ADRBK20.92272037
80CDK60.91763977
81BMPR1B0.91519078
82CAMKK20.89743374
83CHEK20.86260935
84GRK10.86069445
85DYRK1B0.85896501
86INSRR0.85561879
87PLK40.83756802
88MAP3K90.83599235
89DAPK20.83571092
90TESK20.81239289
91CAMK2B0.81193612
92NME10.80942984
93CAMK2A0.80185800
94LMTK20.78140155
95FLT30.75932815
96TYRO30.75725371
97MAP3K110.74380378
98CHEK10.72855401
99CAMK40.72842698
100CDK140.72208834
101TTN0.71994736
102KSR10.70921809
103SGK2230.70378919
104SGK4940.70378919
105LRRK20.70114587
106CDK40.69452349
107AKT20.67576220
108CSNK1E0.67452777
109ATR0.67258825
110MAPK150.67203382
111FGFR20.66624621
112GRK60.65694427
113CDK180.65248632
114MELK0.64498117
115BRSK20.63614770
116TGFBR10.62128685
117DDR20.61541238
118OXSR10.61193658
119ACVR1B0.61168288
120PTK20.60701559
121CSNK2A20.60508297
122VRK10.58873482
123CDK150.58373192
124PRKCZ0.58056607
125STK40.58013229
126PRKD30.56897975
127MAP2K10.56885965
128PKN10.55796325
129ALK0.55577918
130CDK11A0.54956782
131EIF2AK30.54845344
132MAP3K120.54811189
133MAP3K60.54285229
134MKNK10.54273630
135SIK30.53879570
136PAK10.53761700
137DAPK10.53499987
138FGFR10.53160673
139MKNK20.53146148
140DYRK30.52515042
141EPHB20.50973013
142MAP2K20.49941388
143TAOK20.49842524
144ICK0.49618555
145SGK20.49587809
146WNK40.49329892
147ATM0.48836279
148MAP3K20.48315962
149ARAF0.48017962
150NME20.47723027
151CDK20.47628470
152CSNK2A10.47596436
153CSNK1A10.47568134
154* PRKACA0.47515299
155CAMK2D0.44127145
156BRAF0.44099146
157STK30.43549091
158TLK10.43504181
159CCNB10.43275640
160MTOR0.42829087
161ERBB30.42267108
162NUAK10.42127861
163CAMK2G0.41179765
164PRKAA10.40909915
165PRKG10.40834927
166SCYL20.39921973
167PRKACB0.38417272
168OBSCN0.37094955
169BMX0.37038254
170CDK30.36890347
171ADRBK10.35065556
172CAMK10.34425898
173MAP3K50.34212165
174DAPK30.34006133
175CSNK1D0.33275805
176FRK0.33233836
177LIMK10.33067871
178STK380.32593212
179STK160.32429863
180RPS6KA50.32342962
181CDK10.31509144
182CAMK1G0.28716900

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.86506828
2* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.98985050
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.95715011
4* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.73838623
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.59195920
6* Chemical carcinogenesis_Homo sapiens_hsa052042.48476357
7GABAergic synapse_Homo sapiens_hsa047272.44476801
8Mismatch repair_Homo sapiens_hsa034302.39558356
9Steroid biosynthesis_Homo sapiens_hsa001002.34825548
10Protein export_Homo sapiens_hsa030602.33327914
11One carbon pool by folate_Homo sapiens_hsa006702.29728545
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.25973127
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16210020
14DNA replication_Homo sapiens_hsa030302.11107635
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09948784
16Synaptic vesicle cycle_Homo sapiens_hsa047212.05317270
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.04698176
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02686311
19* Glutathione metabolism_Homo sapiens_hsa004802.01896356
20Biosynthesis of amino acids_Homo sapiens_hsa012301.97860841
21Proteasome_Homo sapiens_hsa030501.97072324
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.92173262
23Phototransduction_Homo sapiens_hsa047441.89942702
24Nitrogen metabolism_Homo sapiens_hsa009101.86989919
25Morphine addiction_Homo sapiens_hsa050321.85637847
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84111222
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.83792232
28Ribosome_Homo sapiens_hsa030101.83223356
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79974349
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79961380
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79912238
32Glutamatergic synapse_Homo sapiens_hsa047241.79285099
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79019757
34Carbon metabolism_Homo sapiens_hsa012001.77005749
35Phenylalanine metabolism_Homo sapiens_hsa003601.75424687
36Collecting duct acid secretion_Homo sapiens_hsa049661.75247947
37Taste transduction_Homo sapiens_hsa047421.73348856
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.72285920
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71816118
40RNA transport_Homo sapiens_hsa030131.71751745
41Cocaine addiction_Homo sapiens_hsa050301.70019943
42Tyrosine metabolism_Homo sapiens_hsa003501.68451997
43Retinol metabolism_Homo sapiens_hsa008301.68010422
44Dopaminergic synapse_Homo sapiens_hsa047281.64786555
45Circadian entrainment_Homo sapiens_hsa047131.64542369
46Fatty acid degradation_Homo sapiens_hsa000711.64153421
47RNA polymerase_Homo sapiens_hsa030201.62084809
48Arginine biosynthesis_Homo sapiens_hsa002201.61567158
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58972301
50Cardiac muscle contraction_Homo sapiens_hsa042601.54602273
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.53829642
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.50157306
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49941396
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.49646888
55Pyruvate metabolism_Homo sapiens_hsa006201.48516132
56Selenocompound metabolism_Homo sapiens_hsa004501.48465742
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.46014847
58Propanoate metabolism_Homo sapiens_hsa006401.44286143
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42052155
60Spliceosome_Homo sapiens_hsa030401.40144758
61Amphetamine addiction_Homo sapiens_hsa050311.36155724
62Nucleotide excision repair_Homo sapiens_hsa034201.35393749
63Axon guidance_Homo sapiens_hsa043601.33902039
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33321957
65Sulfur metabolism_Homo sapiens_hsa009201.28658953
66Pyrimidine metabolism_Homo sapiens_hsa002401.26925159
67Histidine metabolism_Homo sapiens_hsa003401.24715114
68Tryptophan metabolism_Homo sapiens_hsa003801.23473276
69beta-Alanine metabolism_Homo sapiens_hsa004101.15253561
70Sulfur relay system_Homo sapiens_hsa041221.12881444
71Folate biosynthesis_Homo sapiens_hsa007901.12113904
72Serotonergic synapse_Homo sapiens_hsa047261.09812566
73Fructose and mannose metabolism_Homo sapiens_hsa000511.05921368
74Insulin secretion_Homo sapiens_hsa049111.05708980
75Homologous recombination_Homo sapiens_hsa034401.02159969
76Cyanoamino acid metabolism_Homo sapiens_hsa004601.02014141
77Oxidative phosphorylation_Homo sapiens_hsa001901.00899296
78Huntingtons disease_Homo sapiens_hsa050160.97948512
79Vibrio cholerae infection_Homo sapiens_hsa051100.97432031
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97114289
81Fatty acid elongation_Homo sapiens_hsa000620.96461968
82Regulation of autophagy_Homo sapiens_hsa041400.94919385
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.94526392
84Peroxisome_Homo sapiens_hsa041460.94090076
85Base excision repair_Homo sapiens_hsa034100.91301264
86Fatty acid metabolism_Homo sapiens_hsa012120.90745116
87Circadian rhythm_Homo sapiens_hsa047100.90144709
88Cell cycle_Homo sapiens_hsa041100.89500805
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.89252836
90Olfactory transduction_Homo sapiens_hsa047400.88747868
91Linoleic acid metabolism_Homo sapiens_hsa005910.87942481
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86918702
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85778961
94Fat digestion and absorption_Homo sapiens_hsa049750.84654389
95Ether lipid metabolism_Homo sapiens_hsa005650.83756797
96Long-term depression_Homo sapiens_hsa047300.83376071
97Arginine and proline metabolism_Homo sapiens_hsa003300.82689755
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82317088
99Pentose phosphate pathway_Homo sapiens_hsa000300.81497241
100Butanoate metabolism_Homo sapiens_hsa006500.80345635
101Parkinsons disease_Homo sapiens_hsa050120.79474179
102Cholinergic synapse_Homo sapiens_hsa047250.77636215
103Starch and sucrose metabolism_Homo sapiens_hsa005000.76262195
104PPAR signaling pathway_Homo sapiens_hsa033200.75721960
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75570985
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75114994
107RNA degradation_Homo sapiens_hsa030180.74333504
108Galactose metabolism_Homo sapiens_hsa000520.71610694
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71566645
110Gap junction_Homo sapiens_hsa045400.70810286
111Hippo signaling pathway_Homo sapiens_hsa043900.70790570
112Bile secretion_Homo sapiens_hsa049760.70159134
113Tight junction_Homo sapiens_hsa045300.68219915
114Non-homologous end-joining_Homo sapiens_hsa034500.65355075
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62799085
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62757906
117Complement and coagulation cascades_Homo sapiens_hsa046100.61412190
118Vitamin digestion and absorption_Homo sapiens_hsa049770.60638760
119Fanconi anemia pathway_Homo sapiens_hsa034600.60587345
120mRNA surveillance pathway_Homo sapiens_hsa030150.59149984
121Metabolic pathways_Homo sapiens_hsa011000.58457184
122Alcoholism_Homo sapiens_hsa050340.57798239
123Basal cell carcinoma_Homo sapiens_hsa052170.57630830
124Ovarian steroidogenesis_Homo sapiens_hsa049130.57605199
125Basal transcription factors_Homo sapiens_hsa030220.55076792
126Renin secretion_Homo sapiens_hsa049240.53906222
127Salivary secretion_Homo sapiens_hsa049700.53704691
128Caffeine metabolism_Homo sapiens_hsa002320.53316969
129Purine metabolism_Homo sapiens_hsa002300.53075607
130p53 signaling pathway_Homo sapiens_hsa041150.52347516
131Adherens junction_Homo sapiens_hsa045200.52166106
132TGF-beta signaling pathway_Homo sapiens_hsa043500.51682127
133cAMP signaling pathway_Homo sapiens_hsa040240.49778438
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48873551
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48504024
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46186710
137Thyroid cancer_Homo sapiens_hsa052160.45086892
138Bladder cancer_Homo sapiens_hsa052190.44635195
139Vitamin B6 metabolism_Homo sapiens_hsa007500.44400317
140Alzheimers disease_Homo sapiens_hsa050100.43437778
141Calcium signaling pathway_Homo sapiens_hsa040200.43334859
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42512452
143Gastric acid secretion_Homo sapiens_hsa049710.41151709
144Oxytocin signaling pathway_Homo sapiens_hsa049210.40676360
145Fatty acid biosynthesis_Homo sapiens_hsa000610.40225844
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40143944
147Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40103236
148Melanogenesis_Homo sapiens_hsa049160.39280040
149Wnt signaling pathway_Homo sapiens_hsa043100.38077315
150Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37277766
151Mineral absorption_Homo sapiens_hsa049780.34275049
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33321904
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30718047
154Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29875487
155Hedgehog signaling pathway_Homo sapiens_hsa043400.29795166
156Oocyte meiosis_Homo sapiens_hsa041140.29048920

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »