GSTA9P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.17792409
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.56914263
3cytidine deamination (GO:0009972)6.47900645
4cytidine metabolic process (GO:0046087)6.47900645
5cytidine catabolic process (GO:0006216)6.47900645
6regulation of memory T cell differentiation (GO:0043380)6.39941988
7estrogen biosynthetic process (GO:0006703)6.19694592
8pyrimidine ribonucleoside catabolic process (GO:0046133)5.50787099
9regulation of activation of Janus kinase activity (GO:0010533)4.54309345
10positive regulation of defense response to virus by host (GO:0002230)4.49844398
11rRNA catabolic process (GO:0016075)4.41486753
12multicellular organism reproduction (GO:0032504)4.18299847
13androgen biosynthetic process (GO:0006702)4.01601900
14negative regulation by host of viral transcription (GO:0043922)3.91640127
15cellular ketone body metabolic process (GO:0046950)3.90307639
16positive regulation of natural killer cell differentiation (GO:0032825)3.87608589
17GDP-mannose metabolic process (GO:0019673)3.85401227
18Arp2/3 complex-mediated actin nucleation (GO:0034314)3.81188217
19sperm capacitation (GO:0048240)3.65783320
20negative regulation of thymocyte apoptotic process (GO:0070244)3.56839198
21negative regulation of T cell apoptotic process (GO:0070233)3.55828610
22cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.55037436
23ketone body metabolic process (GO:1902224)3.49145778
24response to interferon-beta (GO:0035456)3.48881202
25actin nucleation (GO:0045010)3.48547120
26progesterone metabolic process (GO:0042448)3.41965437
27negative regulation of viral genome replication (GO:0045071)3.41743797
28positive regulation of interleukin-17 production (GO:0032740)3.41741648
29protein polyglutamylation (GO:0018095)3.41126825
30glucocorticoid biosynthetic process (GO:0006704)3.31598226
31negative regulation of macroautophagy (GO:0016242)3.31488993
32ubiquinone biosynthetic process (GO:0006744)3.31015234
33C21-steroid hormone biosynthetic process (GO:0006700)3.22887946
34tachykinin receptor signaling pathway (GO:0007217)3.20110950
35mucosal-associated lymphoid tissue development (GO:0048537)3.15372647
36Peyers patch development (GO:0048541)3.15372647
37histone arginine methylation (GO:0034969)3.13502718
38negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.12385031
39positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11148348
40mannosylation (GO:0097502)3.10696743
41ketone biosynthetic process (GO:0042181)3.07792455
42regulation of defense response to virus by host (GO:0050691)3.07591248
43glucocorticoid metabolic process (GO:0008211)3.06466916
44regulation of B cell receptor signaling pathway (GO:0050855)3.05745071
45phosphorylated carbohydrate dephosphorylation (GO:0046838)3.04984870
46inositol phosphate dephosphorylation (GO:0046855)3.04984870
47metallo-sulfur cluster assembly (GO:0031163)3.03541314
48iron-sulfur cluster assembly (GO:0016226)3.03541314
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03067950
50peptidyl-arginine omega-N-methylation (GO:0035247)3.02015231
51negative regulation of interleukin-10 production (GO:0032693)3.00184579
52DNA demethylation (GO:0080111)2.98544677
53positive regulation of cell fate commitment (GO:0010455)2.97902721
54cellular response to antibiotic (GO:0071236)2.97327892
55axoneme assembly (GO:0035082)2.96345638
56ubiquinone metabolic process (GO:0006743)2.92594276
57hormone biosynthetic process (GO:0042446)2.91395098
58negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.91189857
59protein-chromophore linkage (GO:0018298)2.90264577
60regulation of germinal center formation (GO:0002634)2.88176909
61pyrimidine nucleoside catabolic process (GO:0046135)2.87776658
62organelle disassembly (GO:1903008)2.86232751
63regulation of T cell mediated cytotoxicity (GO:0001914)2.83339183
64positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.82446480
65negative regulation of heart rate (GO:0010459)2.81022002
66base-excision repair, AP site formation (GO:0006285)2.79690365
67inositol phosphate catabolic process (GO:0071545)2.76742855
68regulation of natural killer cell differentiation (GO:0032823)2.73746339
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73034202
70adaptation of signaling pathway (GO:0023058)2.72931783
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71088491
72dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.70793338
73quinone biosynthetic process (GO:1901663)2.69824429
74benzene-containing compound metabolic process (GO:0042537)2.69074819
75DNA dealkylation (GO:0035510)2.67416770
76diterpenoid biosynthetic process (GO:0016102)2.67172020
77regulation of interleukin-8 secretion (GO:2000482)2.66833872
78positive regulation of T-helper 1 type immune response (GO:0002827)2.66680510
79rRNA modification (GO:0000154)2.63814126
80rRNA methylation (GO:0031167)2.62964626
81negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.62890033
82positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.62630755
83regulation of leukocyte mediated cytotoxicity (GO:0001910)2.62057005
84modulation by host of symbiont transcription (GO:0052472)2.61118629
85modulation by host of viral transcription (GO:0043921)2.61118629
86negative regulation of T cell receptor signaling pathway (GO:0050860)2.60238732
87modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)2.58494722
88response to follicle-stimulating hormone (GO:0032354)2.57576502
89negative regulation of lymphocyte apoptotic process (GO:0070229)2.57206740
90membrane tubulation (GO:0097320)2.57072211
91tryptophan metabolic process (GO:0006568)2.57010981
92terpenoid biosynthetic process (GO:0016114)2.56018958
93C21-steroid hormone metabolic process (GO:0008207)2.55945005
94estrogen metabolic process (GO:0008210)2.55427360
95regulation of B cell differentiation (GO:0045577)2.55213825
96short-chain fatty acid metabolic process (GO:0046459)2.53586304
97L-alpha-amino acid transmembrane transport (GO:1902475)2.53294934
98misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.52347826
99reproduction (GO:0000003)2.51595119
100cellular response to cadmium ion (GO:0071276)2.47449169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human4.24369678
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.84374211
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.84325760
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.77833002
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.27257009
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.18595400
7ZNF274_21170338_ChIP-Seq_K562_Hela2.89272235
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.63348765
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.51802792
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.51342742
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.40779336
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.33112344
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25560231
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.20231088
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.15689048
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14506574
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09515274
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.03763416
19VDR_23849224_ChIP-Seq_CD4+_Human1.99509681
20VDR_22108803_ChIP-Seq_LS180_Human1.98004001
21IGF1R_20145208_ChIP-Seq_DFB_Human1.96080150
22GATA3_26560356_Chip-Seq_TH2_Human1.93704925
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92882637
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.76848161
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.65596072
26TP53_22573176_ChIP-Seq_HFKS_Human1.63269613
27MYB_26560356_Chip-Seq_TH2_Human1.60596792
28LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58769417
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56774622
30BCAT_22108803_ChIP-Seq_LS180_Human1.55669588
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.55433957
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.55308161
33GATA3_27048872_Chip-Seq_THYMUS_Human1.51169386
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50356481
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48508672
36ELK1_19687146_ChIP-ChIP_HELA_Human1.42322764
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38981895
38PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.35554728
39FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34333921
40MYC_18940864_ChIP-ChIP_HL60_Human1.32555672
41AR_20517297_ChIP-Seq_VCAP_Human1.32328055
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.31140252
43RUNX_20019798_ChIP-Seq_JUKART_Human1.26824555
44ER_23166858_ChIP-Seq_MCF-7_Human1.26516111
45GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.25710686
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.25674214
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25671130
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24178797
49TAF2_19829295_ChIP-Seq_ESCs_Human1.22390114
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21271592
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.21271592
52IRF1_19129219_ChIP-ChIP_H3396_Human1.20592575
53FOXP3_21729870_ChIP-Seq_TREG_Human1.19063934
54NCOR_22424771_ChIP-Seq_293T_Human1.19055277
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19042225
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18741374
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17614165
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17416369
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17398576
60MYC_19829295_ChIP-Seq_ESCs_Human1.16641024
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16511966
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16228639
63GATA1_22025678_ChIP-Seq_K562_Human1.15068642
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14713664
65CBP_20019798_ChIP-Seq_JUKART_Human1.14567210
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14567210
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.12859968
68NANOG_20526341_ChIP-Seq_ESCs_Human1.12734294
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09467254
70TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07322803
71GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06802582
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06425443
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05119559
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03416734
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03065032
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02898442
77GATA6_21074721_ChIP-Seq_CACO-2_Human1.02804747
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02093816
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02093457
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01976238
81HTT_18923047_ChIP-ChIP_STHdh_Human1.01328280
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00688945
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00494682
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00185964
85ERG_20517297_ChIP-Seq_VCAP_Human1.00072935
86TCF4_22108803_ChIP-Seq_LS180_Human0.99661398
87STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99628478
88FUS_26573619_Chip-Seq_HEK293_Human0.98138028
89SOX2_19829295_ChIP-Seq_ESCs_Human0.97210111
90NANOG_19829295_ChIP-Seq_ESCs_Human0.97210111
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97206088
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95440685
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94688562
94CIITA_25753668_ChIP-Seq_RAJI_Human0.94616151
95MYB_26560356_Chip-Seq_TH1_Human0.94002259
96GATA3_26560356_Chip-Seq_TH1_Human0.93861185
97RAC3_21632823_ChIP-Seq_H3396_Human0.93086623
98EWS_26573619_Chip-Seq_HEK293_Human0.92515113
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91951450
100CEBPB_22108803_ChIP-Seq_LS180_Human0.89807177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.63650780
2MP0003011_delayed_dark_adaptation4.53639154
3MP0002638_abnormal_pupillary_reflex4.35415265
4MP0003763_abnormal_thymus_physiology2.69405069
5MP0000013_abnormal_adipose_tissue2.57156903
6MP0003806_abnormal_nucleotide_metabolis2.55705297
7MP0005671_abnormal_response_to2.42527876
8MP0005645_abnormal_hypothalamus_physiol2.32897424
9MP0004043_abnormal_pH_regulation2.19184268
10MP0009785_altered_susceptibility_to2.12477111
11MP0002132_abnormal_respiratory_system2.06435019
12MP0005253_abnormal_eye_physiology1.93002905
13MP0003786_premature_aging1.89288958
14MP0001764_abnormal_homeostasis1.86561755
15MP0002909_abnormal_adrenal_gland1.81899580
16MP0001984_abnormal_olfaction1.79755135
17MP0008995_early_reproductive_senescence1.78351548
18MP0002822_catalepsy1.76207578
19MP0002277_abnormal_respiratory_mucosa1.74640545
20MP0001835_abnormal_antigen_presentation1.73676645
21MP0000639_abnormal_adrenal_gland1.70605104
22MP0001986_abnormal_taste_sensitivity1.69570732
23MP0002876_abnormal_thyroid_physiology1.69107907
24MP0005075_abnormal_melanosome_morpholog1.65665810
25MP0008872_abnormal_physiological_respon1.63383879
26MP0008058_abnormal_DNA_repair1.61962108
27MP0005167_abnormal_blood-brain_barrier1.60914391
28MP0002148_abnormal_hypersensitivity_rea1.60463089
29MP0002396_abnormal_hematopoietic_system1.57939480
30MP0002102_abnormal_ear_morphology1.49516030
31MP0006276_abnormal_autonomic_nervous1.46203318
32MP0005389_reproductive_system_phenotype1.45663642
33MP0008875_abnormal_xenobiotic_pharmacok1.39208949
34MP0005551_abnormal_eye_electrophysiolog1.38712760
35MP0005310_abnormal_salivary_gland1.34376502
36MP0002723_abnormal_immune_serum1.33300839
37MP0001661_extended_life_span1.31787976
38MP0001800_abnormal_humoral_immune1.31597899
39MP0001968_abnormal_touch/_nociception1.31365358
40MP0002095_abnormal_skin_pigmentation1.26028578
41MP0010368_abnormal_lymphatic_system1.24344550
42MP0002006_tumorigenesis1.23968267
43MP0010386_abnormal_urinary_bladder1.21948477
44MP0005025_abnormal_response_to1.20488215
45MP0002736_abnormal_nociception_after1.20469708
46MP0002420_abnormal_adaptive_immunity1.19401048
47MP0001919_abnormal_reproductive_system1.19051925
48MP0001819_abnormal_immune_cell1.18851555
49MP0004147_increased_porphyrin_level1.18563525
50MP0006036_abnormal_mitochondrial_physio1.17994656
51MP0000383_abnormal_hair_follicle1.17417269
52MP0002160_abnormal_reproductive_system1.15134797
53MP0004142_abnormal_muscle_tone1.14708024
54MP0003646_muscle_fatigue1.13051451
55MP0009764_decreased_sensitivity_to1.12490630
56MP0008789_abnormal_olfactory_epithelium1.12469653
57MP0005000_abnormal_immune_tolerance1.12234360
58MP0005379_endocrine/exocrine_gland_phen1.11917086
59MP0002837_dystrophic_cardiac_calcinosis1.11842426
60MP0001905_abnormal_dopamine_level1.11041328
61MP0002938_white_spotting1.06876375
62MP0000716_abnormal_immune_system1.05078827
63MP0002166_altered_tumor_susceptibility1.03290659
64MP0010155_abnormal_intestine_physiology1.01876249
65MP0006072_abnormal_retinal_apoptosis1.01026868
66MP0009333_abnormal_splenocyte_physiolog1.00568196
67MP0006035_abnormal_mitochondrial_morpho0.99498071
68MP0004484_altered_response_of0.99169542
69MP0002933_joint_inflammation0.98944374
70MP0004019_abnormal_vitamin_homeostasis0.98932452
71MP0002398_abnormal_bone_marrow0.98267422
72MP0005410_abnormal_fertilization0.97691270
73MP0003195_calcinosis0.96432384
74MP0000703_abnormal_thymus_morphology0.93656957
75MP0003718_maternal_effect0.91862570
76MP0006082_CNS_inflammation0.91746715
77MP0000689_abnormal_spleen_morphology0.91258427
78MP0001929_abnormal_gametogenesis0.89717391
79MP0002452_abnormal_antigen_presenting0.89608819
80MP0003136_yellow_coat_color0.87706435
81MP0002722_abnormal_immune_system0.86306093
82MP0000371_diluted_coat_color0.84644348
83MP0005636_abnormal_mineral_homeostasis0.83041387
84MP0003950_abnormal_plasma_membrane0.80855227
85MP0005084_abnormal_gallbladder_morpholo0.80600851
86MP0002429_abnormal_blood_cell0.80594558
87MP0002075_abnormal_coat/hair_pigmentati0.79698528
88MP0005220_abnormal_exocrine_pancreas0.79198133
89MP0005187_abnormal_penis_morphology0.77991210
90MP0003866_abnormal_defecation0.75554502
91MP0002163_abnormal_gland_morphology0.74392799
92MP0009643_abnormal_urine_homeostasis0.74374075
93MP0001845_abnormal_inflammatory_respons0.73868029
94MP0002733_abnormal_thermal_nociception0.73567990
95MP0008469_abnormal_protein_level0.72871468
96MP0000647_abnormal_sebaceous_gland0.71600615
97MP0001765_abnormal_ion_homeostasis0.69508549
98MP0004134_abnormal_chest_morphology0.69295500
99MP0002693_abnormal_pancreas_physiology0.69236850
100MP0001790_abnormal_immune_system0.68878146

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)4.25357798
2T lymphocytopenia (HP:0005403)4.12931931
3Renal salt wasting (HP:0000127)4.11209950
4Hypokalemic alkalosis (HP:0001949)3.96022386
5Abnormality of T cell number (HP:0011839)3.87460930
6Congenital stationary night blindness (HP:0007642)3.73108774
7Type I transferrin isoform profile (HP:0003642)3.68876416
8IgG deficiency (HP:0004315)3.49358071
9Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.43427338
10Abnormal protein N-linked glycosylation (HP:0012347)3.43427338
11Abnormal protein glycosylation (HP:0012346)3.43427338
12Abnormal glycosylation (HP:0012345)3.43427338
13Anhidrosis (HP:0000970)3.40964426
14Conical tooth (HP:0000698)3.26623407
15Pancreatic cysts (HP:0001737)3.21703952
16Renal cortical cysts (HP:0000803)3.12095135
17Thyroiditis (HP:0100646)3.11952482
18Severe combined immunodeficiency (HP:0004430)3.09694850
19Increased intramyocellular lipid droplets (HP:0012240)3.03979718
20Hyperaldosteronism (HP:0000859)3.02055148
21Decreased circulating renin level (HP:0003351)2.99298882
22Abnormal delayed hypersensitivity skin test (HP:0002963)2.90406292
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.88585782
24Optic neuritis (HP:0100653)2.84708768
25Retrobulbar optic neuritis (HP:0100654)2.84708768
26Abnormality of T cells (HP:0002843)2.81633571
27Increased muscle lipid content (HP:0009058)2.75899259
28Panhypogammaglobulinemia (HP:0003139)2.65952995
29Abolished electroretinogram (ERG) (HP:0000550)2.59891332
30True hermaphroditism (HP:0010459)2.59321266
31Abnormal rod and cone electroretinograms (HP:0008323)2.59262193
32Severe visual impairment (HP:0001141)2.57493616
33Concave nail (HP:0001598)2.57116557
34Abnormality of B cell number (HP:0010975)2.55116999
35Autoimmune hemolytic anemia (HP:0001890)2.52485092
36Dysautonomia (HP:0002459)2.43284168
37Gaze-evoked nystagmus (HP:0000640)2.42115574
38Encephalitis (HP:0002383)2.40668623
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.39686095
40Dicarboxylic aciduria (HP:0003215)2.39686095
41Abnormality of eosinophils (HP:0001879)2.37154968
42Recurrent cutaneous fungal infections (HP:0011370)2.36737291
43Chronic mucocutaneous candidiasis (HP:0002728)2.36737291
44Reduced antithrombin III activity (HP:0001976)2.33433036
45B lymphocytopenia (HP:0010976)2.33141591
46Pancreatic fibrosis (HP:0100732)2.29757034
47Combined immunodeficiency (HP:0005387)2.27302399
48Medial flaring of the eyebrow (HP:0010747)2.21648284
49Keratitis (HP:0000491)2.19059094
50Abnormality of the renal cortex (HP:0011035)2.18051369
51Brittle hair (HP:0002299)2.17929717
52Alkalosis (HP:0001948)2.15630254
53Abnormality of T cell physiology (HP:0011840)2.15179458
54Methylmalonic aciduria (HP:0012120)2.14771982
55Bilateral sensorineural hearing impairment (HP:0008619)2.13463756
56Orchitis (HP:0100796)2.10835207
57Eosinophilia (HP:0001880)2.09180676
58Methylmalonic acidemia (HP:0002912)2.08704596
59Abnormality of midbrain morphology (HP:0002418)2.07805817
60Molar tooth sign on MRI (HP:0002419)2.07805817
61Albinism (HP:0001022)2.05238161
62Arthropathy (HP:0003040)2.03850061
63Abnormality of renin-angiotensin system (HP:0000847)2.03052975
64Aplasia/Hypoplasia of the spleen (HP:0010451)2.00559526
65Hypoproteinemia (HP:0003075)1.99258567
66Keratoconjunctivitis (HP:0001096)1.97490358
67Mitochondrial inheritance (HP:0001427)1.95211976
68Spastic paraparesis (HP:0002313)1.94228844
69Bilateral microphthalmos (HP:0007633)1.94170609
70Hematochezia (HP:0002573)1.89648471
71Abnormality of the prostate (HP:0008775)1.89183392
72Epidermoid cyst (HP:0200040)1.87832508
73Hypotrichosis (HP:0001006)1.87550835
74Hypoplasia of the thymus (HP:0000778)1.87382769
75Abnormality of dental color (HP:0011073)1.86710976
76Asplenia (HP:0001746)1.86350834
77Abnormal mitochondria in muscle tissue (HP:0008316)1.85583835
78Abnormality of alanine metabolism (HP:0010916)1.84375388
79Hyperalaninemia (HP:0003348)1.84375388
80Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84375388
81Autoimmune thrombocytopenia (HP:0001973)1.83753136
82Inflammation of the large intestine (HP:0002037)1.82959068
83Metabolic alkalosis (HP:0200114)1.82614833
84Decreased central vision (HP:0007663)1.82407544
85Abnormal biliary tract physiology (HP:0012439)1.82338009
86Bile duct proliferation (HP:0001408)1.82338009
87Increased CSF lactate (HP:0002490)1.81836408
88Increased hepatocellular lipid droplets (HP:0006565)1.81610964
89Pulmonary embolism (HP:0002204)1.81484192
90Lipid accumulation in hepatocytes (HP:0006561)1.80098906
91Aplasia/hypoplasia of the uterus (HP:0008684)1.79033443
92Tinnitus (HP:0000360)1.78853335
93Elevated erythrocyte sedimentation rate (HP:0003565)1.78353166
94Pulmonary fibrosis (HP:0002206)1.77698058
95Myositis (HP:0100614)1.77346299
96Microretrognathia (HP:0000308)1.75700340
97Keratoconjunctivitis sicca (HP:0001097)1.75386630
98Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74818194
99Absent speech (HP:0001344)1.73264215
100Respiratory difficulties (HP:0002880)1.72331343

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.78995930
2ZAK3.66264684
3TAOK33.63762637
4MAP4K23.13473887
5ADRBK22.71620247
6KDR2.56055822
7FRK2.52499899
8EIF2AK32.35852461
9NUAK12.25735148
10BCKDK2.23209946
11TLK12.07095172
12INSRR2.05213890
13FES2.04010141
14MST41.93703531
15ITK1.88541020
16VRK11.83527554
17KIT1.81960645
18TESK21.80809584
19GRK11.78986422
20PDK21.65625086
21WNK31.64629944
22MAP2K71.49805978
23MATK1.44758689
24PRKCQ1.30592702
25PINK11.29530022
26JAK31.22516132
27VRK21.21317337
28PHKG21.18579907
29PHKG11.18579907
30IKBKE1.17082394
31RIPK41.16660106
32TYK21.14878680
33JAK11.14751315
34BMPR1B1.12588762
35OXSR11.11907462
36WNK41.10921435
37MAP3K41.09593018
38NLK1.09452750
39SIK31.08594764
40NTRK11.07686080
41CAMKK21.04880440
42MAP3K50.98841615
43RPS6KA50.97961313
44BMPR20.97885351
45LCK0.92094512
46TEC0.86961304
47MUSK0.86024054
48IKBKB0.79733347
49BTK0.76900315
50IGF1R0.76087308
51LMTK20.75763741
52GRK70.75455072
53FLT30.75306448
54PIK3CA0.75178849
55CSNK1G10.71912879
56STK390.71440189
57CDC70.70644939
58CSF1R0.67458975
59TBK10.66550299
60GRK50.66275530
61LYN0.63821467
62PRKCE0.62557245
63ADRBK10.56637900
64BRSK20.56575104
65EIF2AK20.56373107
66MAPK130.55960764
67TRIM280.54925223
68STK38L0.54886376
69PASK0.54516992
70CSNK1G30.54183998
71CSK0.52792350
72CSNK1A10.52047512
73CDK80.50382504
74ERBB30.50178833
75AURKA0.49571253
76HCK0.49237980
77TESK10.48005422
78FER0.47990779
79CHEK20.45441861
80NEK10.44130362
81SCYL20.43712451
82PIM10.43157083
83ATR0.43053474
84DYRK1A0.42961083
85PRKAA10.40649960
86TIE10.40611565
87FYN0.40123202
88PRKACA0.38103824
89NEK60.38035063
90CSNK1A1L0.36845501
91CAMK10.36809292
92PKN10.33675017
93ERBB20.33529745
94DYRK20.33445721
95AKT20.32035936
96MAP2K60.31930657
97STK240.31842513
98MELK0.31515573
99SIK20.31452805
100PRKCA0.31364914

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.93922531
2Proteasome_Homo sapiens_hsa030503.66989446
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.62196540
4Butanoate metabolism_Homo sapiens_hsa006502.32626877
5Homologous recombination_Homo sapiens_hsa034402.22297214
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.09802144
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09327396
8Selenocompound metabolism_Homo sapiens_hsa004502.07907449
9Basal transcription factors_Homo sapiens_hsa030221.95591410
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.94738811
11Nitrogen metabolism_Homo sapiens_hsa009101.88522072
12Oxidative phosphorylation_Homo sapiens_hsa001901.72895426
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70537986
14Regulation of autophagy_Homo sapiens_hsa041401.70490375
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69567417
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68468505
17Retinol metabolism_Homo sapiens_hsa008301.67954841
18Peroxisome_Homo sapiens_hsa041461.64181921
19Graft-versus-host disease_Homo sapiens_hsa053321.60633711
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.60141793
21RNA degradation_Homo sapiens_hsa030181.54842824
22Chemical carcinogenesis_Homo sapiens_hsa052041.50263757
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.49134781
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.48613224
25Linoleic acid metabolism_Homo sapiens_hsa005911.48006953
26Rheumatoid arthritis_Homo sapiens_hsa053231.43366572
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41629068
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41197548
29Sulfur metabolism_Homo sapiens_hsa009201.38849013
30Phototransduction_Homo sapiens_hsa047441.38812132
31Ovarian steroidogenesis_Homo sapiens_hsa049131.33510397
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31569711
33Collecting duct acid secretion_Homo sapiens_hsa049661.30787757
34Hematopoietic cell lineage_Homo sapiens_hsa046401.29786205
35Antigen processing and presentation_Homo sapiens_hsa046121.29475193
36Olfactory transduction_Homo sapiens_hsa047401.28825749
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26407239
38Parkinsons disease_Homo sapiens_hsa050121.24001684
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22800973
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19580275
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17983249
42Autoimmune thyroid disease_Homo sapiens_hsa053201.16303683
43Steroid biosynthesis_Homo sapiens_hsa001001.13977724
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12018684
45Caffeine metabolism_Homo sapiens_hsa002321.09273187
46Fanconi anemia pathway_Homo sapiens_hsa034601.06622161
47RNA polymerase_Homo sapiens_hsa030201.04455535
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03236405
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01722172
50Non-homologous end-joining_Homo sapiens_hsa034500.98225056
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95740183
52Nucleotide excision repair_Homo sapiens_hsa034200.95732584
53Tryptophan metabolism_Homo sapiens_hsa003800.95438721
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90830036
55Protein export_Homo sapiens_hsa030600.89748167
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89737431
57One carbon pool by folate_Homo sapiens_hsa006700.88321384
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87397216
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85542729
60Allograft rejection_Homo sapiens_hsa053300.83412841
61Propanoate metabolism_Homo sapiens_hsa006400.83177485
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82346337
63Type I diabetes mellitus_Homo sapiens_hsa049400.80525439
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80255129
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71828592
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70682120
67Morphine addiction_Homo sapiens_hsa050320.67892777
68Fatty acid degradation_Homo sapiens_hsa000710.64087242
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.62431187
70Alzheimers disease_Homo sapiens_hsa050100.62093571
71Arachidonic acid metabolism_Homo sapiens_hsa005900.61805611
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61175261
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.58751639
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58509516
75Measles_Homo sapiens_hsa051620.57473839
76Metabolic pathways_Homo sapiens_hsa011000.54672591
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54150375
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53022660
79N-Glycan biosynthesis_Homo sapiens_hsa005100.52514780
80Base excision repair_Homo sapiens_hsa034100.51906881
81Fat digestion and absorption_Homo sapiens_hsa049750.51216480
82Ether lipid metabolism_Homo sapiens_hsa005650.51158840
83GABAergic synapse_Homo sapiens_hsa047270.51038604
84Huntingtons disease_Homo sapiens_hsa050160.50605560
85ABC transporters_Homo sapiens_hsa020100.49419370
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.48921587
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47347575
88Asthma_Homo sapiens_hsa053100.46512440
89Cardiac muscle contraction_Homo sapiens_hsa042600.45637521
90T cell receptor signaling pathway_Homo sapiens_hsa046600.41458759
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37405967
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.35245219
93Fatty acid metabolism_Homo sapiens_hsa012120.33565644
94Herpes simplex infection_Homo sapiens_hsa051680.30640167
95Nicotine addiction_Homo sapiens_hsa050330.30225919
96Glutathione metabolism_Homo sapiens_hsa004800.30121960
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30007962
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.27994612
99Purine metabolism_Homo sapiens_hsa002300.27687500
100Taste transduction_Homo sapiens_hsa047420.27431727

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