GSTK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.27328940
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.27328940
3L-phenylalanine metabolic process (GO:0006558)6.99153308
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.99153308
5aromatic amino acid family catabolic process (GO:0009074)6.44145961
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.01292947
7indole-containing compound catabolic process (GO:0042436)5.72902926
8indolalkylamine catabolic process (GO:0046218)5.72902926
9tryptophan catabolic process (GO:0006569)5.72902926
10glyoxylate metabolic process (GO:0046487)5.67887401
11kynurenine metabolic process (GO:0070189)5.63965132
12bile acid biosynthetic process (GO:0006699)5.61790332
13alpha-linolenic acid metabolic process (GO:0036109)5.51308545
14tryptophan metabolic process (GO:0006568)5.38609419
15cysteine metabolic process (GO:0006534)5.36489904
16sulfur amino acid catabolic process (GO:0000098)5.30510486
17antigen processing and presentation of endogenous antigen (GO:0019883)5.20367900
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.15738568
19high-density lipoprotein particle remodeling (GO:0034375)5.11519781
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.08683840
21positive regulation of gamma-delta T cell activation (GO:0046645)5.08172823
22urea metabolic process (GO:0019627)5.07861614
23urea cycle (GO:0000050)5.07861614
24negative regulation of fibrinolysis (GO:0051918)4.95153841
25peptidyl-glutamic acid carboxylation (GO:0017187)4.91142398
26protein carboxylation (GO:0018214)4.91142398
27serine family amino acid catabolic process (GO:0009071)4.89409308
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88400786
29regulation of triglyceride catabolic process (GO:0010896)4.84515536
30lysine metabolic process (GO:0006553)4.84341604
31lysine catabolic process (GO:0006554)4.84341604
32complement activation, alternative pathway (GO:0006957)4.79443505
33regulation of fibrinolysis (GO:0051917)4.78893032
34bile acid metabolic process (GO:0008206)4.77499762
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.75959110
36homocysteine metabolic process (GO:0050667)4.75401659
37nitrogen cycle metabolic process (GO:0071941)4.72632340
38regulation of protein activation cascade (GO:2000257)4.70502627
39aromatic amino acid family metabolic process (GO:0009072)4.66982654
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.66333380
41negative regulation of cell killing (GO:0031342)4.66333380
42amino-acid betaine metabolic process (GO:0006577)4.61894529
43regulation of cholesterol esterification (GO:0010872)4.59582404
44alpha-amino acid catabolic process (GO:1901606)4.53985646
45reverse cholesterol transport (GO:0043691)4.49194723
46cellular ketone body metabolic process (GO:0046950)4.48664220
47tyrosine metabolic process (GO:0006570)4.44800225
48protein-lipid complex remodeling (GO:0034368)4.41456217
49macromolecular complex remodeling (GO:0034367)4.41456217
50plasma lipoprotein particle remodeling (GO:0034369)4.41456217
51regulation of complement activation (GO:0030449)4.40914417
52coenzyme catabolic process (GO:0009109)4.37576723
53acylglycerol homeostasis (GO:0055090)4.34200867
54triglyceride homeostasis (GO:0070328)4.34200867
55ethanol oxidation (GO:0006069)4.32590668
56negative regulation of cholesterol transport (GO:0032375)4.26792353
57negative regulation of sterol transport (GO:0032372)4.26792353
58cellular glucuronidation (GO:0052695)4.25549064
59cellular amino acid catabolic process (GO:0009063)4.25329885
60phospholipid efflux (GO:0033700)4.22380431
61short-chain fatty acid metabolic process (GO:0046459)4.17426655
62plasma lipoprotein particle clearance (GO:0034381)4.13273646
63glycine metabolic process (GO:0006544)4.09369115
64glutamate metabolic process (GO:0006536)4.08624007
65cellular modified amino acid catabolic process (GO:0042219)4.08360641
66serine family amino acid metabolic process (GO:0009069)4.07566530
67regulation of gamma-delta T cell differentiation (GO:0045586)4.05595494
68indolalkylamine metabolic process (GO:0006586)4.03326345
69benzene-containing compound metabolic process (GO:0042537)4.02159836
70amine catabolic process (GO:0009310)4.00434011
71cellular biogenic amine catabolic process (GO:0042402)4.00434011
72bile acid and bile salt transport (GO:0015721)4.00209890
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.95038677
74serine family amino acid biosynthetic process (GO:0009070)3.93560692
75regulation of gamma-delta T cell activation (GO:0046643)3.93479021
76acetyl-CoA metabolic process (GO:0006084)3.92085048
77positive thymic T cell selection (GO:0045059)3.88735119
78ketone body metabolic process (GO:1902224)3.87941484
79organic acid catabolic process (GO:0016054)3.86120145
80carboxylic acid catabolic process (GO:0046395)3.86120145
81drug catabolic process (GO:0042737)3.85635506
82fatty acid beta-oxidation (GO:0006635)3.85635328
83negative T cell selection (GO:0043383)3.84945948
84dicarboxylic acid biosynthetic process (GO:0043650)3.84851569
85imidazole-containing compound metabolic process (GO:0052803)3.84226214
86uronic acid metabolic process (GO:0006063)3.83748285
87glucuronate metabolic process (GO:0019585)3.83748285
88aspartate family amino acid catabolic process (GO:0009068)3.83380475
89negative thymic T cell selection (GO:0045060)3.83193063
90immunoglobulin mediated immune response (GO:0016064)3.82868713
91cholesterol efflux (GO:0033344)3.82345834
92aldehyde catabolic process (GO:0046185)3.81762066
93arginine metabolic process (GO:0006525)3.77786308
94fatty acid oxidation (GO:0019395)3.76673217
95low-density lipoprotein particle remodeling (GO:0034374)3.75595762
96monocarboxylic acid catabolic process (GO:0072329)3.74437675
97positive regulation of lipoprotein lipase activity (GO:0051006)3.73149426
98positive regulation of triglyceride lipase activity (GO:0061365)3.73149426
99lipid oxidation (GO:0034440)3.71062451
100fatty acid catabolic process (GO:0009062)3.69378443
101plasma lipoprotein particle assembly (GO:0034377)3.68092613
102neutrophil activation involved in immune response (GO:0002283)3.67391219
103negative regulation of lipase activity (GO:0060192)3.67217675
104cofactor catabolic process (GO:0051187)3.67173375
1052-oxoglutarate metabolic process (GO:0006103)3.67132996
106detection of bacterium (GO:0016045)3.64604703
107positive regulation of lipid catabolic process (GO:0050996)3.62365386
108response to nitrosative stress (GO:0051409)3.62045197
109fibrinolysis (GO:0042730)3.61399297
110cholesterol homeostasis (GO:0042632)3.58300867
111carnitine metabolic process (GO:0009437)3.57567546
112very-low-density lipoprotein particle assembly (GO:0034379)3.55959848
113detection of other organism (GO:0098543)3.54393525
114phospholipid homeostasis (GO:0055091)3.53325288
115regulation of B cell receptor signaling pathway (GO:0050855)3.52554466
116sterol homeostasis (GO:0055092)3.52299915
117regulation of bile acid biosynthetic process (GO:0070857)3.51073555
118flavonoid metabolic process (GO:0009812)3.47489481
119positive regulation of B cell differentiation (GO:0045579)3.33141491
120positive T cell selection (GO:0043368)3.31216861
121leukocyte aggregation (GO:0070486)3.21084646
122thymic T cell selection (GO:0045061)3.20695539
123regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.19667299
124T cell selection (GO:0045058)3.19653472
125regulation of T cell tolerance induction (GO:0002664)3.17397102
126type I interferon signaling pathway (GO:0060337)3.14431224
127cellular response to type I interferon (GO:0071357)3.14431224
128response to type I interferon (GO:0034340)3.12628186
129T cell migration (GO:0072678)3.12105018
130negative regulation of lymphocyte mediated immunity (GO:0002707)3.11321762
131response to interleukin-15 (GO:0070672)3.09694791
132regulation of regulatory T cell differentiation (GO:0045589)3.06979882
133positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.06509685
134antigen processing and presentation via MHC class Ib (GO:0002475)3.04025168
135response to interferon-beta (GO:0035456)3.03311752
136regulation of tolerance induction (GO:0002643)3.03120361
137regulation of T cell mediated cytotoxicity (GO:0001914)3.00128138
138positive regulation of T cell mediated cytotoxicity (GO:0001916)2.99620562
139tolerance induction (GO:0002507)2.99013990
140negative regulation of leukocyte mediated immunity (GO:0002704)2.96810653
141regulation of antigen processing and presentation (GO:0002577)2.96263622
142positive regulation of antigen processing and presentation (GO:0002579)2.95173838
143interferon-gamma-mediated signaling pathway (GO:0060333)2.93586449
144regulation of dendritic cell antigen processing and presentation (GO:0002604)2.92865607
145cellular response to interleukin-15 (GO:0071350)2.90553661
146regulation of B cell differentiation (GO:0045577)2.89629844
147B cell mediated immunity (GO:0019724)2.89383006
148regulation of alpha-beta T cell proliferation (GO:0046640)2.88456990
149positive regulation of tolerance induction (GO:0002645)2.84485339
150positive regulation by symbiont of host defense response (GO:0052509)2.80974605
151modulation by symbiont of host defense response (GO:0052031)2.80974605
152modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.80974605
153modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.80974605
154positive regulation by organism of defense response of other organism involved in symbiotic interact2.80974605
155modulation by symbiont of host immune response (GO:0052553)2.80974605
156detection of external biotic stimulus (GO:0098581)2.80300959
157negative regulation of erythrocyte differentiation (GO:0045647)2.79636689
158B cell receptor signaling pathway (GO:0050853)2.79322360
159regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.79272629
160neutrophil activation (GO:0042119)2.78920600
161negative regulation of innate immune response (GO:0045824)2.78778359
162negative regulation of T cell mediated immunity (GO:0002710)2.78093480
163Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76615353
164response to peptidoglycan (GO:0032494)2.70257292
165cellular extravasation (GO:0045123)2.69993367
166positive regulation of granulocyte differentiation (GO:0030854)2.69675678
167regulation of natural killer cell mediated immunity (GO:0002715)2.66193177
168regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.66193177
169negative regulation of interleukin-12 production (GO:0032695)2.63951692
170macrophage activation involved in immune response (GO:0002281)2.63769120
171mature B cell differentiation involved in immune response (GO:0002313)2.61740105
172myeloid cell activation involved in immune response (GO:0002275)2.61226704
173regulation of leukocyte mediated cytotoxicity (GO:0001910)2.59226211
174antigen receptor-mediated signaling pathway (GO:0050851)2.56849311
175granulocyte activation (GO:0036230)2.56757615
176cytidine deamination (GO:0009972)2.55576444
177cytidine metabolic process (GO:0046087)2.55576444
178cytidine catabolic process (GO:0006216)2.55576444
179positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.55458531
180mast cell activation (GO:0045576)2.54466841
181T cell receptor signaling pathway (GO:0050852)2.51711051
182negative regulation of cytokine production involved in immune response (GO:0002719)2.50960491
183T cell costimulation (GO:0031295)2.50915908
184regulation of interleukin-2 biosynthetic process (GO:0045076)2.48577671
185detection of biotic stimulus (GO:0009595)2.47736850
186lymphocyte costimulation (GO:0031294)2.46975120
187leukocyte degranulation (GO:0043299)2.46115363
188respiratory burst (GO:0045730)2.45624826
189autophagic vacuole fusion (GO:0000046)2.44467053
190dendritic cell chemotaxis (GO:0002407)2.43563388
191activated T cell proliferation (GO:0050798)2.43281683
192regulation of mast cell degranulation (GO:0043304)2.43259274
193lymphocyte chemotaxis (GO:0048247)2.40143294
194cellular response to interferon-beta (GO:0035458)2.38975382
195defense response to protozoan (GO:0042832)2.36849400
196regulation of interferon-beta biosynthetic process (GO:0045357)2.33574801
197pyrimidine ribonucleoside catabolic process (GO:0046133)2.33473350
198positive regulation of alpha-beta T cell proliferation (GO:0046641)2.32541488
199regulation of cell killing (GO:0031341)2.31787490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.94554949
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.82513747
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.47866489
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.15377028
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.70142473
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.06978937
7BP1_19119308_ChIP-ChIP_Hs578T_Human4.79067367
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.70852635
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.75069718
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.60107860
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.31943014
12IRF8_21731497_ChIP-ChIP_J774_Mouse3.02712729
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.94808429
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72957605
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46931348
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41234208
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40374843
18RUNX_20019798_ChIP-Seq_JUKART_Human2.34041375
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25595853
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23776403
21VDR_21846776_ChIP-Seq_THP-1_Human2.22066276
22MYB_26560356_Chip-Seq_TH2_Human2.19455373
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13245039
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.10928606
25MAF_26560356_Chip-Seq_TH1_Human2.06317745
26VDR_24763502_ChIP-Seq_THP-1_Human2.06100386
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02089443
28SPI1_23547873_ChIP-Seq_NB4_Human2.01047147
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3466750
30* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98146134
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93409957
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93376841
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91093877
34UTX_26944678_Chip-Seq_JUKART_Human1.90692678
35SCL_19346495_ChIP-Seq_HPC-7_Human1.86440840
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85920532
37MYB_26560356_Chip-Seq_TH1_Human1.83602754
38SPI1_23127762_ChIP-Seq_K562_Human1.82862961
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82690730
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.80556756
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77781268
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77043768
43CLOCK_20551151_ChIP-Seq_293T_Human1.73723059
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68650079
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67820440
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64901127
47MAF_26560356_Chip-Seq_TH2_Human1.62763807
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60731673
49GATA1_22025678_ChIP-Seq_K562_Human1.56628004
50HTT_18923047_ChIP-ChIP_STHdh_Human1.56123755
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53220297
52FOXA2_19822575_ChIP-Seq_HepG2_Human1.52224473
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49960874
54BCL6_27268052_Chip-Seq_Bcells_Human1.49541659
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45581315
56* GATA3_27048872_Chip-Seq_THYMUS_Human1.45456294
57MYC_22102868_ChIP-Seq_BL_Human1.40317766
58* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36402352
59BCOR_27268052_Chip-Seq_Bcells_Human1.36285750
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.33904990
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.33238237
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31184629
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30899104
64HNF4A_19822575_ChIP-Seq_HepG2_Human1.29562861
65GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29253486
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29116328
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.28896412
68* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26567333
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25510988
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25440744
71GATA3_26560356_Chip-Seq_TH2_Human1.24121494
72* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22995207
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.22709522
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22514196
75TCF7_22412390_ChIP-Seq_EML_Mouse1.21381720
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20187251
77* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19718330
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19466033
79* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13706808
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13208478
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12681900
82* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10825862
83SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10756013
84* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10496818
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.10004790
86P300_27268052_Chip-Seq_Bcells_Human1.09236121
87STAT1_20625510_ChIP-Seq_HELA_Human1.07832810
88RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07427248
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04944221
90KDM2B_26808549_Chip-Seq_DND41_Human1.04696733
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04145581
92* VDR_24787735_ChIP-Seq_THP-1_Human1.03940144
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03476897
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03251237
95P68_20966046_ChIP-Seq_HELA_Human1.02469080
96ESR2_21235772_ChIP-Seq_MCF-7_Human1.00661923
97SPI1_20517297_ChIP-Seq_HL60_Human0.99730543
98GATA4_25053715_ChIP-Seq_YYC3_Human0.98248858
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97836145
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95400593
101SA1_27219007_Chip-Seq_Bcells_Human0.95099351
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.95017661
103E2F1_20622854_ChIP-Seq_HELA_Human0.94470184
104CTCF_26484167_Chip-Seq_Bcells_Mouse0.92582752
105CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91762333
106AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90431747
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89602171
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89524448
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88715890
110TET1_21451524_ChIP-Seq_MESCs_Mouse0.88474412
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87060068
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85343656
113ZNF263_19887448_ChIP-Seq_K562_Human0.82103973
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79012236
115NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79012236
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78321484
117* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77892109
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77462112
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76393374
120IRF8_22096565_ChIP-ChIP_GC-B_Human0.75981687
121BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74722074
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.73825833
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72972257
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.72802524
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70402642
126ESR1_21235772_ChIP-Seq_MCF-7_Human0.69244912
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69127781
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68215096
129CEBPB_22108803_ChIP-Seq_LS180_Human0.65914809
130Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65805150
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.64595750
132KAP1_22055183_ChIP-Seq_ESCs_Mouse0.63722026
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.63623214
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.63098061
135AR_20517297_ChIP-Seq_VCAP_Human0.62507300
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.62427705
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.61796046
138PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60349313
139EGR1_19032775_ChIP-ChIP_M12_Human0.59573164
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.59176501
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.58323445
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.58170295
143LXR_22292898_ChIP-Seq_THP-1_Human0.57753187
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.56937649
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.56313439
146TBX20_22080862_ChIP-Seq_HEART_Mouse0.56313439
147RARB_24833708_ChIP-Seq_LIVER_Mouse0.53993077
148CBP_21632823_ChIP-Seq_H3396_Human0.52825886
149SOX2_20726797_ChIP-Seq_SW620_Human0.52795190
150PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.52682908
151ESET_19884257_ChIP-Seq_ESCs_Mouse0.51731548
152P53_21459846_ChIP-Seq_SAOS-2_Human0.51536694
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49609849
154E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.49476977
155BCAT_22108803_ChIP-Seq_LS180_Human0.49297673
156GATA1_19941826_ChIP-Seq_K562_Human0.48878249
157PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.48741868
158TAF2_19829295_ChIP-Seq_ESCs_Human0.48319916
159TRIM28_21343339_ChIP-Seq_HEK293_Human0.48212561
160TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.47838924
161MYC_19915707_ChIP-ChIP_AK7_Human0.47572884
162ERG_21242973_ChIP-ChIP_JURKAT_Human0.46869480
163GATA2_19941826_ChIP-Seq_K562_Human0.46545215
164FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.45848212
165GATA6_25053715_ChIP-Seq_YYC3_Human0.45409323
166SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.45362184
167GATA3_24758297_ChIP-Seq_MCF-7_Human0.44960098
168ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.44316718
169CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.44076347
170ERG_20517297_ChIP-Seq_VCAP_Human0.43449149
171FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43130138
172FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.42044020
173CSB_26484114_Chip-Seq_FIBROBLAST_Human0.41749654
174* STAT1_17558387_ChIP-Seq_HELA_Human0.41528171
175P63_26484246_Chip-Seq_KERATINOCYTES_Human0.41446442
176STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40631071
177GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.40006280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.89140761
2MP0005360_urolithiasis7.22023758
3MP0005085_abnormal_gallbladder_physiolo6.11670634
4MP0005365_abnormal_bile_salt5.94216681
5MP0008875_abnormal_xenobiotic_pharmacok5.00657492
6MP0003806_abnormal_nucleotide_metabolis4.40756424
7MP0003252_abnormal_bile_duct3.66461355
8MP0010329_abnormal_lipoprotein_level3.48051563
9MP0001835_abnormal_antigen_presentation3.44896701
10MP0009840_abnormal_foam_cell3.26140873
11MP0003436_decreased_susceptibility_to3.23239761
12MP0005671_abnormal_response_to3.04471571
13MP0005083_abnormal_biliary_tract3.04044811
14MP0005332_abnormal_amino_acid2.90655721
15MP0001666_abnormal_nutrient_absorption2.78617650
16MP0003195_calcinosis2.71572206
17MP0009785_altered_susceptibility_to2.59992383
18MP0005025_abnormal_response_to2.56968940
19MP0001800_abnormal_humoral_immune2.56737138
20MP0005000_abnormal_immune_tolerance2.53845409
21MP0003763_abnormal_thymus_physiology2.51897342
22MP0005387_immune_system_phenotype2.44776172
23MP0001790_abnormal_immune_system2.44776172
24MP0000685_abnormal_immune_system2.43475947
25MP0002419_abnormal_innate_immunity2.39863075
26MP0002148_abnormal_hypersensitivity_rea2.33236979
27MP0002723_abnormal_immune_serum2.26909565
28MP0003191_abnormal_cellular_cholesterol2.19538004
29MP0002118_abnormal_lipid_homeostasis2.15853206
30MP0002452_abnormal_antigen_presenting2.15767517
31MP0002420_abnormal_adaptive_immunity2.15352647
32MP0003303_peritoneal_inflammation2.14206515
33MP0006082_CNS_inflammation2.14195010
34MP0010155_abnormal_intestine_physiology2.13596822
35MP0001819_abnormal_immune_cell2.13263793
36MP0004019_abnormal_vitamin_homeostasis2.10241886
37MP0009333_abnormal_splenocyte_physiolog2.08150112
38MP0000609_abnormal_liver_physiology2.03808927
39MP0002138_abnormal_hepatobiliary_system1.89775740
40MP0005319_abnormal_enzyme/_coenzyme1.83388657
41MP0003868_abnormal_feces_composition1.80317512
42MP0003866_abnormal_defecation1.78996667
43MP0001845_abnormal_inflammatory_respons1.73236147
44MP0001533_abnormal_skeleton_physiology1.67900788
45MP0003300_gastrointestinal_ulcer1.65738926
46MP0000465_gastrointestinal_hemorrhage1.65095095
47MP0000716_abnormal_immune_system1.64051842
48MP0005584_abnormal_enzyme/coenzyme_acti1.63542027
49MP0002398_abnormal_bone_marrow1.62416399
50MP0005451_abnormal_body_composition1.61774440
51MP0002405_respiratory_system_inflammati1.58963419
52MP0001764_abnormal_homeostasis1.58053455
53MP0004947_skin_inflammation1.55227350
54MP0003186_abnormal_redox_activity1.53857369
55MP0001873_stomach_inflammation1.51820609
56MP0003011_delayed_dark_adaptation1.43591104
57MP0002166_altered_tumor_susceptibility1.42963430
58MP0000689_abnormal_spleen_morphology1.40854347
59MP0009643_abnormal_urine_homeostasis1.40825592
60MP0009697_abnormal_copulation1.39397213
61MP0002722_abnormal_immune_system1.34691484
62MP0002429_abnormal_blood_cell1.31382236
63MP0003183_abnormal_peptide_metabolism1.27696634
64MP0003172_abnormal_lysosome_physiology1.23721256
65MP0002396_abnormal_hematopoietic_system1.22375110
66MP0003656_abnormal_erythrocyte_physiolo1.22042560
67MP0000858_altered_metastatic_potential1.17828826
68MP0006036_abnormal_mitochondrial_physio1.14363898
69MP0001851_eye_inflammation1.13952113
70MP0004130_abnormal_muscle_cell1.12034348
71MP0002933_joint_inflammation1.10728425
72MP0000703_abnormal_thymus_morphology1.10704692
73MP0009278_abnormal_bone_marrow1.09766555
74MP0005397_hematopoietic_system_phenotyp1.09422008
75MP0001545_abnormal_hematopoietic_system1.09422008
76MP0005647_abnormal_sex_gland1.09413481
77MP0010368_abnormal_lymphatic_system1.09261781
78MP0003828_pulmonary_edema1.08103075
79MP0000598_abnormal_liver_morphology1.07015309
80MP0003705_abnormal_hypodermis_morpholog1.06068620
81MP0002837_dystrophic_cardiac_calcinosis1.04490030
82MP0008260_abnormal_autophagy1.04234333
83MP0005670_abnormal_white_adipose1.03245326
84MP0005636_abnormal_mineral_homeostasis1.00187671
85MP0002254_reproductive_system_inflammat0.97973938
86MP0000604_amyloidosis0.97791226
87MP0009764_decreased_sensitivity_to0.97662972
88MP0009763_increased_sensitivity_to0.94948286
89MP0002998_abnormal_bone_remodeling0.93195025
90MP0005084_abnormal_gallbladder_morpholo0.92440957
91MP0000343_altered_response_to0.91006266
92MP0001663_abnormal_digestive_system0.90266297
93MP0005075_abnormal_melanosome_morpholog0.89814242
94MP0003690_abnormal_glial_cell0.86783379
95MP0002006_tumorigenesis0.86410332
96MP0005164_abnormal_response_to0.86115998
97MP0004883_abnormal_blood_vessel0.86020441
98MP0009642_abnormal_blood_homeostasis0.85465423
99MP0008469_abnormal_protein_level0.84410413
100MP0004510_myositis0.84079604
101MP0005408_hypopigmentation0.83467316
102MP0002971_abnormal_brown_adipose0.83207485
103MP0005310_abnormal_salivary_gland0.83083699
104MP0005376_homeostasis/metabolism_phenot0.80925936
105MP0002078_abnormal_glucose_homeostasis0.79680923
106MP0003045_fibrosis0.77834981
107MP0005666_abnormal_adipose_tissue0.76039389
108MP0003448_altered_tumor_morphology0.74955328
109MP0005266_abnormal_metabolism0.74820562
110MP0005535_abnormal_body_temperature0.73625754
111MP0005334_abnormal_fat_pad0.72723463
112MP0009765_abnormal_xenobiotic_induced0.71833901
113MP0005220_abnormal_exocrine_pancreas0.71013192
114MP0002876_abnormal_thyroid_physiology0.70895305
115MP0001661_extended_life_span0.70430610
116MP0001756_abnormal_urination0.67681632
117MP0003329_amyloid_beta_deposits0.66835560
118MP0004043_abnormal_pH_regulation0.64743409
119MP0006035_abnormal_mitochondrial_morpho0.61603973
120MP0004782_abnormal_surfactant_physiolog0.60170446
121MP0002136_abnormal_kidney_physiology0.55146219
122MP0005448_abnormal_energy_balance0.54646458
123MP0003724_increased_susceptibility_to0.50322729
124MP0009053_abnormal_anal_canal0.50118810
125MP0003638_abnormal_response/metabolism_0.49785284
126MP0000230_abnormal_systemic_arterial0.48830823
127MP0003075_altered_response_to0.48341829
128MP0002796_impaired_skin_barrier0.47783144
129MP0005330_cardiomyopathy0.47641882
130MP0009384_cardiac_valve_regurgitation0.47568929
131MP0000639_abnormal_adrenal_gland0.47349442
132MP0003953_abnormal_hormone_level0.41160387
133MP0008874_decreased_physiological_sensi0.40787815
134MP0001853_heart_inflammation0.40535917
135MP0004381_abnormal_hair_follicle0.39235623
136MP0005165_increased_susceptibility_to0.38954148
137MP0002822_catalepsy0.38907525
138MP0005464_abnormal_platelet_physiology0.38651775
139MP0004185_abnormal_adipocyte_glucose0.38092419
140MP0008873_increased_physiological_sensi0.37836345
141MP0009115_abnormal_fat_cell0.37154080
142MP0005395_other_phenotype0.36941584
143MP0000249_abnormal_blood_vessel0.36202342
144MP0004147_increased_porphyrin_level0.36094694
145MP0000579_abnormal_nail_morphology0.36034582
146MP0005166_decreased_susceptibility_to0.35944002
147MP0005058_abnormal_lysosome_morphology0.35608387
148MP0002295_abnormal_pulmonary_circulatio0.35394250
149MP0005167_abnormal_blood-brain_barrier0.35006190
150MP0002269_muscular_atrophy0.34925686
151MP0002928_abnormal_bile_duct0.34657894
152MP0003646_muscle_fatigue0.33030340
153MP0001765_abnormal_ion_homeostasis0.32515129
154MP0003718_maternal_effect0.32316007
155MP0002970_abnormal_white_adipose0.29849951
156MP0005595_abnormal_vascular_smooth0.29767814
157MP0009672_abnormal_birth_weight0.29146499
158MP0002132_abnormal_respiratory_system0.27276967

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.00642103
2Intrahepatic cholestasis (HP:0001406)6.74827110
3Deep venous thrombosis (HP:0002625)6.61727207
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.00841732
5Xanthomatosis (HP:0000991)5.91380540
6Hypobetalipoproteinemia (HP:0003563)5.88889715
7Prolonged partial thromboplastin time (HP:0003645)5.85767332
8Hyperlipoproteinemia (HP:0010980)5.40882013
9Hyperammonemia (HP:0001987)4.79567062
10Elevated erythrocyte sedimentation rate (HP:0003565)4.73541804
11Complement deficiency (HP:0004431)4.71031717
12Hyperglycinemia (HP:0002154)4.66998810
13Eczematoid dermatitis (HP:0000976)4.66759691
14Ketosis (HP:0001946)4.58301533
15Hyperglycinuria (HP:0003108)4.53373819
16Hypolipoproteinemia (HP:0010981)4.52395235
17Abnormality of serine family amino acid metabolism (HP:0010894)4.45893944
18Abnormality of glycine metabolism (HP:0010895)4.45893944
19Myositis (HP:0100614)4.30624337
20Hypoglycemic coma (HP:0001325)4.20848178
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.18889020
22Joint hemorrhage (HP:0005261)4.17108291
23Epidermoid cyst (HP:0200040)4.07501397
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.04091280
25Abnormality of glutamine family amino acid metabolism (HP:0010902)4.04068541
26Hypoalphalipoproteinemia (HP:0003233)4.02962761
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.98841831
28Recurrent abscess formation (HP:0002722)3.98841211
29Abnormality of methionine metabolism (HP:0010901)3.96237434
30Fat malabsorption (HP:0002630)3.95308864
31Abnormality of the common coagulation pathway (HP:0010990)3.87308745
32Abnormality of fatty-acid metabolism (HP:0004359)3.81689486
33Recurrent bacterial skin infections (HP:0005406)3.79629193
34Abnormality of macrophages (HP:0004311)3.77130212
35Stomatitis (HP:0010280)3.74661581
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.62370159
37Ketoacidosis (HP:0001993)3.61791111
38Recurrent gram-negative bacterial infections (HP:0005420)3.52591209
39Abnormality of the intrinsic pathway (HP:0010989)3.44252508
40Recurrent fungal infections (HP:0002841)3.43246759
41Orchitis (HP:0100796)3.41783556
42Abnormality of complement system (HP:0005339)3.37389346
43Abnormal delayed hypersensitivity skin test (HP:0002963)3.33439500
44Obstructive lung disease (HP:0006536)3.30804797
45Chronic obstructive pulmonary disease (HP:0006510)3.30804797
46Hypercholesterolemia (HP:0003124)3.29193863
47Meningitis (HP:0001287)3.27734157
48Abnormality of pyrimidine metabolism (HP:0004353)3.24837888
49Conjugated hyperbilirubinemia (HP:0002908)3.23733806
50Abnormality of dicarboxylic acid metabolism (HP:0010995)3.19750514
51Dicarboxylic aciduria (HP:0003215)3.19750514
52Delayed CNS myelination (HP:0002188)3.19033888
53Abnormality of serum amino acid levels (HP:0003112)3.19011044
54Optic neuritis (HP:0100653)3.15849742
55Retrobulbar optic neuritis (HP:0100654)3.15849742
56Hyperbilirubinemia (HP:0002904)3.10905189
57Steatorrhea (HP:0002570)3.10888267
58Pustule (HP:0200039)3.06637906
59Metabolic acidosis (HP:0001942)3.03628279
60T lymphocytopenia (HP:0005403)3.03175491
61Petechiae (HP:0000967)2.97485507
62Abnormality of T cell number (HP:0011839)2.96239870
63Abnormality of nucleobase metabolism (HP:0010932)2.95552027
64Lethargy (HP:0001254)2.94329283
65Gastrointestinal infarctions (HP:0005244)2.94264843
66Recurrent cutaneous fungal infections (HP:0011370)2.94136797
67Chronic mucocutaneous candidiasis (HP:0002728)2.94136797
68Panhypogammaglobulinemia (HP:0003139)2.93769615
69Recurrent skin infections (HP:0001581)2.93053448
70Vasculitis (HP:0002633)2.90206710
71Cerebral edema (HP:0002181)2.88024121
72Mediastinal lymphadenopathy (HP:0100721)2.87425339
73Prolonged bleeding time (HP:0003010)2.86074420
74Encephalitis (HP:0002383)2.84895587
75Agammaglobulinemia (HP:0004432)2.83703275
76Abnormality of T cells (HP:0002843)2.83464541
77Abnormality of purine metabolism (HP:0004352)2.80909097
78Purpura (HP:0000979)2.79610275
79Gout (HP:0001997)2.79012675
80Recurrent viral infections (HP:0004429)2.77846149
81Pulmonary infiltrates (HP:0002113)2.77112518
82Spontaneous hematomas (HP:0007420)2.75924186
83Epistaxis (HP:0000421)2.74503986
84Gingival bleeding (HP:0000225)2.73894796
85Autoimmune hemolytic anemia (HP:0001890)2.68877547
86Chronic diarrhea (HP:0002028)2.66993919
87Hepatocellular carcinoma (HP:0001402)2.66631041
88Increased IgE level (HP:0003212)2.64057975
89Skin nodule (HP:0200036)2.59508382
90Vascular calcification (HP:0004934)2.59043397
91Myocardial infarction (HP:0001658)2.57972377
92Inflammation of the large intestine (HP:0002037)2.56209028
93Hemoptysis (HP:0002105)2.55943849
94Increased IgM level (HP:0003496)2.53787516
95Colitis (HP:0002583)2.53025446
96Generalized aminoaciduria (HP:0002909)2.52623743
97Abnormality of T cell physiology (HP:0011840)2.51123337
98Increased serum ferritin (HP:0003281)2.50667329
99Granulocytopenia (HP:0001913)2.50282207
100Gastrointestinal inflammation (HP:0004386)2.49340597
101Hypoglycemic seizures (HP:0002173)2.48626031
102Spontaneous abortion (HP:0005268)2.48470964
103Pulmonary embolism (HP:0002204)2.48106633
104Systemic lupus erythematosus (HP:0002725)2.47527614
105Urticaria (HP:0001025)2.44194895
106Chest pain (HP:0100749)2.41527365
107Abnormal gallbladder morphology (HP:0012437)2.40808737
108Abnormality of liposaccharide metabolism (HP:0010968)2.39372431
109Abnormality of glycosphingolipid metabolism (HP:0004343)2.39372431
110Abnormality of glycolipid metabolism (HP:0010969)2.39372431
111Vomiting (HP:0002013)2.39293953
112Joint swelling (HP:0001386)2.39096153
113Malnutrition (HP:0004395)2.37873631
114Gingivitis (HP:0000230)2.36127007
115Cholelithiasis (HP:0001081)2.35959068
116Dysostosis multiplex (HP:0000943)2.33435098
117Vacuolated lymphocytes (HP:0001922)2.33393941
118Hypochromic microcytic anemia (HP:0004840)2.31651131
119Hypergammaglobulinemia (HP:0010702)2.31168890
120Abnormality of iron homeostasis (HP:0011031)2.31116366
121Cardiovascular calcification (HP:0011915)2.28857954
122Leukocytosis (HP:0001974)2.26747903
123Irritability (HP:0000737)2.24499087
124Pancreatitis (HP:0001733)2.24127290
125Recurrent bronchitis (HP:0002837)2.23266025
126Keratoconjunctivitis sicca (HP:0001097)2.20559094
127Amyloidosis (HP:0011034)2.20279857
128Enlarged kidneys (HP:0000105)2.20013639
129Neonatal onset (HP:0003623)2.19939020
130Proximal tubulopathy (HP:0000114)2.19710456
131Cellulitis (HP:0100658)2.18982923
132Skin rash (HP:0000988)2.18956762
133Spastic diplegia (HP:0001264)2.18833892
134Late onset (HP:0003584)2.18214462
135Cholecystitis (HP:0001082)2.17488874
136Abnormal gallbladder physiology (HP:0012438)2.17488874
137Acanthocytosis (HP:0001927)2.16222374
138Hyperinsulinemic hypoglycemia (HP:0000825)2.15984611
139Arterial thrombosis (HP:0004420)2.13074002
140Brushfield spots (HP:0001088)2.12999951
141Sensorimotor neuropathy (HP:0007141)2.12782580
142Gangrene (HP:0100758)2.12227171
143Glomerulonephritis (HP:0000099)2.09241923
144Anorexia (HP:0002039)2.07916197
145Esophageal varix (HP:0002040)2.07306692
146Hepatosplenomegaly (HP:0001433)2.05819280
147Keratoconjunctivitis (HP:0001096)2.02709344
148Mitral stenosis (HP:0001718)2.02061324
149Hyperuricemia (HP:0002149)2.00804787
150Increased purine levels (HP:0004368)2.00804787
151Abnormality of transition element cation homeostasis (HP:0011030)2.00773012
152Abnormality of urine glucose concentration (HP:0011016)2.00408466
153Glycosuria (HP:0003076)2.00408466
154Autoimmune thrombocytopenia (HP:0001973)2.00197807
155Opisthotonus (HP:0002179)1.99954160
156Renal cortical cysts (HP:0000803)1.99280752
157Abnormality of proline metabolism (HP:0010907)1.98213137
158Hydroxyprolinuria (HP:0003080)1.98213137
159Increased cerebral lipofuscin (HP:0011813)1.97424064
160Myoglobinuria (HP:0002913)1.97255420
161Severe combined immunodeficiency (HP:0004430)1.97046795
162Eosinophilia (HP:0001880)1.96607617
163Lymphopenia (HP:0001888)1.96221245
164Abnormality of the pleura (HP:0002103)1.95991028
165Alkalosis (HP:0001948)1.94902906
166Abnormality of the gallbladder (HP:0005264)1.94692229
167Abnormal cartilage morphology (HP:0002763)1.94438728
168Abnormality of the prostate (HP:0008775)1.93858890
169Hypochromic anemia (HP:0001931)1.91748909
170Seborrheic dermatitis (HP:0001051)1.90160956
171Rickets (HP:0002748)1.89651079
172Abnormality of vitamin metabolism (HP:0100508)1.88308063
173Acute hepatic failure (HP:0006554)1.88253091
174IgG deficiency (HP:0004315)1.87748252
175Asymmetric septal hypertrophy (HP:0001670)1.86280807
176Nausea (HP:0002018)1.86115962
177Hypertensive crisis (HP:0100735)1.85884950
178Chronic otitis media (HP:0000389)1.85362914
179Abnormality of polysaccharide metabolism (HP:0011012)1.84654891
180Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84654891
181Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84654891
182Menorrhagia (HP:0000132)1.84588258
183Elevated hepatic transaminases (HP:0002910)1.83285848
184Hepatic necrosis (HP:0002605)1.82566543
185Hypophosphatemic rickets (HP:0004912)1.81901864
186Thrombophlebitis (HP:0004418)1.79769548
187Acute encephalopathy (HP:0006846)1.79333746
188Hemorrhage of the eye (HP:0011885)1.78753154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.86864344
2MAP4K14.08481033
3SIK14.06075618
4ERN13.86217142
5FGFR43.68818387
6RIPK43.33889800
7TXK3.14856832
8INSRR2.83527854
9FES2.31445233
10PKN22.29069554
11ZAP702.28314517
12TRIB32.14636744
13ERBB42.10680963
14JAK32.10005089
15TESK22.05159345
16TAOK32.04536790
17BLK2.04038951
18MST1R2.01828042
19BTK1.91796002
20PRPF4B1.89288025
21FLT31.85859312
22SYK1.83146830
23ITK1.80982883
24KIT1.80103170
25PIK3CG1.80097882
26PINK11.79665190
27TNK21.75592044
28IRAK41.72624905
29MAP2K41.63394907
30MAPK111.56679570
31TIE11.52796848
32KDR1.49927521
33TEC1.46511638
34EPHB11.44575067
35LATS11.43632965
36TYK21.43332356
37MAP2K31.40850584
38HCK1.34315085
39LCK1.34242671
40PTK61.32963576
41IKBKB1.32796485
42BMPR21.27856401
43MAP3K131.27587695
44LYN1.27377809
45FGFR21.26811236
46ABL21.25981015
47MAP3K31.22648051
48PRKAA21.21116378
49FRK1.20672014
50PDK31.16349859
51PDK41.16349859
52MAP3K71.14862714
53MAPKAPK31.10635879
54MET1.09415201
55MYLK1.09154111
56MAPK121.07063109
57NEK91.06132269
58TESK11.02402027
59LMTK20.99845947
60MAP3K10.95487597
61STK38L0.93751094
62PHKG10.93747909
63PHKG20.93747909
64JAK20.92255921
65MAPK150.90845141
66DAPK20.90736675
67OBSCN0.90518156
68TGFBR20.90049735
69MAPK40.89936344
70TBK10.88932654
71MAP2K60.88746658
72PBK0.84984167
73PIK3CA0.84053435
74GRK60.83730358
75CAMK2G0.81118663
76TTN0.80999670
77WNK40.80475272
78GRK70.79879264
79PDK20.75625337
80MARK30.75097922
81ERBB20.72661435
82TAOK10.72210661
83JAK10.71714151
84PRKACG0.71539304
85HIPK20.70024223
86IRAK30.69463788
87MATK0.67669634
88CAMKK20.67416246
89FGR0.67342140
90EPHA30.67092661
91PRKAA10.66861666
92GSK3A0.65992516
93MAP3K110.64970266
94CAMK1D0.64421344
95STK390.64174150
96STK100.62331815
97CDC42BPA0.62045335
98MAP2K20.61262096
99PRKCZ0.60579982
100SIK30.58612870
101RIPK10.58455632
102PDPK10.56846737
103PRKCQ0.56204875
104OXSR10.55729773
105FGFR30.55717707
106MAP3K140.55553313
107GRK10.55225085
108CSK0.53569934
109TRPM70.52947424
110MAPK70.52106811
111PRKD20.50937744
112SGK2230.50890398
113SGK4940.50890398
114MAP3K120.50566008
115MAPKAPK20.49510678
116FYN0.48470537
117SMG10.48383361
118PRKD10.47659176
119PIM10.47218692
120PKN10.45110719
121SGK30.44107924
122MAP2K10.43408051
123CDK60.42422944
124IRAK10.42088646
125IKBKE0.41427612
126SCYL20.41329775
127CAMKK10.41326816
128DYRK1B0.41307468
129IRAK20.40654485
130PRKG20.40191594
131IGF1R0.39913720
132TLK10.39544519
133PAK30.38039039
134PTK2B0.37767900
135MAP3K60.37296603
136CSF1R0.36961967
137EPHB20.36844899
138PIM20.36070044
139TAOK20.35617108
140MAP3K50.34472254
141PRKCD0.34298733
142SGK20.33718813
143CAMK40.32717803
144CSNK1G10.31890088
145NME20.31184742
146RPS6KC10.30772724
147RPS6KL10.30772724
148NLK0.30674018
149RET0.30522234
150PDK10.30505443
151LRRK20.29586503
152PTK20.29166326

Predicted pathways (KEGG)

RankGene SetZ-score
1Arachidonic acid metabolism_Homo sapiens_hsa005908.37131321
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.11697180
3Nitrogen metabolism_Homo sapiens_hsa009103.34694991
4Allograft rejection_Homo sapiens_hsa053303.32171745
5Graft-versus-host disease_Homo sapiens_hsa053323.27019098
6Autoimmune thyroid disease_Homo sapiens_hsa053203.23555592
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.21585128
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09660716
9Primary immunodeficiency_Homo sapiens_hsa053403.05325128
10Arginine biosynthesis_Homo sapiens_hsa002202.80810899
11Fatty acid degradation_Homo sapiens_hsa000712.74189440
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71815667
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.70896838
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68749315
15Asthma_Homo sapiens_hsa053102.62658938
16Tryptophan metabolism_Homo sapiens_hsa003802.61556234
17Intestinal immune network for IgA production_Homo sapiens_hsa046722.47982117
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47411913
19Propanoate metabolism_Homo sapiens_hsa006402.38159951
20Antigen processing and presentation_Homo sapiens_hsa046122.37606408
21Complement and coagulation cascades_Homo sapiens_hsa046102.37593559
22Other glycan degradation_Homo sapiens_hsa005112.37057558
23Leishmaniasis_Homo sapiens_hsa051402.30498025
24Type I diabetes mellitus_Homo sapiens_hsa049402.30107505
25Butanoate metabolism_Homo sapiens_hsa006502.28522959
26Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25854981
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19328940
28* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11055716
29* Peroxisome_Homo sapiens_hsa041462.10498217
30Fatty acid metabolism_Homo sapiens_hsa012122.04958989
31PPAR signaling pathway_Homo sapiens_hsa033201.94526319
32* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88045757
33* Chemical carcinogenesis_Homo sapiens_hsa052041.87239190
34Histidine metabolism_Homo sapiens_hsa003401.86039711
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84208901
36Hematopoietic cell lineage_Homo sapiens_hsa046401.83544627
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.81600177
38beta-Alanine metabolism_Homo sapiens_hsa004101.77990927
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76906770
40Osteoclast differentiation_Homo sapiens_hsa043801.75603911
41Viral myocarditis_Homo sapiens_hsa054161.75504757
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.69206899
43Fatty acid elongation_Homo sapiens_hsa000621.63800982
44Retinol metabolism_Homo sapiens_hsa008301.62561252
45Caffeine metabolism_Homo sapiens_hsa002321.61519204
46Sulfur metabolism_Homo sapiens_hsa009201.59405224
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58567097
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57964705
49Drug metabolism - other enzymes_Homo sapiens_hsa009831.57237845
50Pyruvate metabolism_Homo sapiens_hsa006201.54849901
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51540333
52Phenylalanine metabolism_Homo sapiens_hsa003601.50379125
53Staphylococcus aureus infection_Homo sapiens_hsa051501.44217469
54Selenocompound metabolism_Homo sapiens_hsa004501.43930551
55Bile secretion_Homo sapiens_hsa049761.40732727
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.40332124
57Tyrosine metabolism_Homo sapiens_hsa003501.37946771
58T cell receptor signaling pathway_Homo sapiens_hsa046601.36753427
59Tuberculosis_Homo sapiens_hsa051521.36515567
60Starch and sucrose metabolism_Homo sapiens_hsa005001.34497440
61Rheumatoid arthritis_Homo sapiens_hsa053231.32295521
62Carbon metabolism_Homo sapiens_hsa012001.31215936
63B cell receptor signaling pathway_Homo sapiens_hsa046621.30449923
64Folate biosynthesis_Homo sapiens_hsa007901.28182843
65Fat digestion and absorption_Homo sapiens_hsa049751.26292610
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.25391180
67Measles_Homo sapiens_hsa051621.21854356
68Steroid biosynthesis_Homo sapiens_hsa001001.21848067
69Biosynthesis of amino acids_Homo sapiens_hsa012301.19871125
70Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19256582
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16158661
72Pertussis_Homo sapiens_hsa051331.15733062
73Toxoplasmosis_Homo sapiens_hsa051451.13833869
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11459747
75Malaria_Homo sapiens_hsa051441.08234478
76Influenza A_Homo sapiens_hsa051641.07843112
77Arginine and proline metabolism_Homo sapiens_hsa003301.07529303
78ABC transporters_Homo sapiens_hsa020101.06661522
79Cyanoamino acid metabolism_Homo sapiens_hsa004601.04464264
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03538605
81NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03475640
82Herpes simplex infection_Homo sapiens_hsa051681.03198615
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99519107
84Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99438024
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96299410
86Sulfur relay system_Homo sapiens_hsa041220.94664369
87Acute myeloid leukemia_Homo sapiens_hsa052210.94656000
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94135934
89Vitamin digestion and absorption_Homo sapiens_hsa049770.91021025
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.90571379
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.87220587
92Chemokine signaling pathway_Homo sapiens_hsa040620.85200346
93Lysosome_Homo sapiens_hsa041420.85192152
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84930113
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84878455
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79613306
97Platelet activation_Homo sapiens_hsa046110.79399144
98Vitamin B6 metabolism_Homo sapiens_hsa007500.79073242
99Glycerolipid metabolism_Homo sapiens_hsa005610.78208121
100TNF signaling pathway_Homo sapiens_hsa046680.77100754
101Lysine degradation_Homo sapiens_hsa003100.75276022
102* Glutathione metabolism_Homo sapiens_hsa004800.75196367
103Phagosome_Homo sapiens_hsa041450.74146943
104Fatty acid biosynthesis_Homo sapiens_hsa000610.73024684
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70192525
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69959682
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.69853573
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68234685
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64659964
110Legionellosis_Homo sapiens_hsa051340.62205172
111Pentose phosphate pathway_Homo sapiens_hsa000300.60818290
112Metabolic pathways_Homo sapiens_hsa011000.53181611
113One carbon pool by folate_Homo sapiens_hsa006700.51384025
114Apoptosis_Homo sapiens_hsa042100.42259995
115Shigellosis_Homo sapiens_hsa051310.40439614
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38844255
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38171534
118Galactose metabolism_Homo sapiens_hsa000520.35783165
119Salmonella infection_Homo sapiens_hsa051320.34454008
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34111944
121Linoleic acid metabolism_Homo sapiens_hsa005910.33342265
122Fructose and mannose metabolism_Homo sapiens_hsa000510.32849597
123Hepatitis B_Homo sapiens_hsa051610.31343172
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.28991430
125Epstein-Barr virus infection_Homo sapiens_hsa051690.27526796
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25549116
127Insulin resistance_Homo sapiens_hsa049310.25209640
128Prion diseases_Homo sapiens_hsa050200.21848265
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.15729447
130Glucagon signaling pathway_Homo sapiens_hsa049220.07482786
131Oxidative phosphorylation_Homo sapiens_hsa001900.05562879
132AMPK signaling pathway_Homo sapiens_hsa041520.05059624
133Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2356494
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2260442
135Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1973684
136African trypanosomiasis_Homo sapiens_hsa05143-0.1845759
137Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1813191
138Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1812334
139Hepatitis C_Homo sapiens_hsa05160-0.1788967
140Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1787198
141Regulation of autophagy_Homo sapiens_hsa04140-0.1584144
142Mineral absorption_Homo sapiens_hsa04978-0.1552583
143Protein digestion and absorption_Homo sapiens_hsa04974-0.1307190
144Ether lipid metabolism_Homo sapiens_hsa00565-0.1069328
145Renin-angiotensin system_Homo sapiens_hsa04614-0.1008992
146Insulin signaling pathway_Homo sapiens_hsa04910-0.0999000
147Alzheimers disease_Homo sapiens_hsa05010-0.0736455
148Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0717965
149Parkinsons disease_Homo sapiens_hsa05012-0.0156905
150Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0108411

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