Rank | Gene Set | Z-score |
---|---|---|
1 | exogenous drug catabolic process (GO:0042738) | 9.07495889 |
2 | * xenobiotic catabolic process (GO:0042178) | 8.86132102 |
3 | * response to nitrosative stress (GO:0051409) | 8.43279170 |
4 | drug catabolic process (GO:0042737) | 8.11895563 |
5 | epoxygenase P450 pathway (GO:0019373) | 7.87119295 |
6 | omega-hydroxylase P450 pathway (GO:0097267) | 7.37215210 |
7 | cellular glucuronidation (GO:0052695) | 7.33373387 |
8 | uronic acid metabolic process (GO:0006063) | 7.32380729 |
9 | glucuronate metabolic process (GO:0019585) | 7.32380729 |
10 | ethanol oxidation (GO:0006069) | 6.19791576 |
11 | drug metabolic process (GO:0017144) | 5.96538947 |
12 | regulation of skeletal muscle contraction (GO:0014819) | 5.74641079 |
13 | oxidative demethylation (GO:0070989) | 5.45261203 |
14 | sulfur amino acid catabolic process (GO:0000098) | 5.39587697 |
15 | ethanol metabolic process (GO:0006067) | 5.11955135 |
16 | one-carbon compound transport (GO:0019755) | 5.06890890 |
17 | * benzene-containing compound metabolic process (GO:0042537) | 5.03977899 |
18 | fibrinolysis (GO:0042730) | 4.91783011 |
19 | regulation of cholesterol biosynthetic process (GO:0045540) | 4.87405744 |
20 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 4.83742956 |
21 | fat-soluble vitamin biosynthetic process (GO:0042362) | 4.83438617 |
22 | * glutathione derivative metabolic process (GO:1901685) | 4.69986074 |
23 | * glutathione derivative biosynthetic process (GO:1901687) | 4.69986074 |
24 | hormone catabolic process (GO:0042447) | 4.67554973 |
25 | coenzyme catabolic process (GO:0009109) | 4.59859741 |
26 | cellular ketone body metabolic process (GO:0046950) | 4.53991911 |
27 | regulation of cholesterol esterification (GO:0010872) | 4.48094164 |
28 | high-density lipoprotein particle remodeling (GO:0034375) | 4.41445580 |
29 | L-phenylalanine catabolic process (GO:0006559) | 4.37652875 |
30 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 4.37652875 |
31 | L-ascorbic acid metabolic process (GO:0019852) | 4.27254965 |
32 | citrulline biosynthetic process (GO:0019240) | 4.25460607 |
33 | glycine metabolic process (GO:0006544) | 4.24174265 |
34 | low-density lipoprotein particle remodeling (GO:0034374) | 4.22990015 |
35 | alkaloid metabolic process (GO:0009820) | 4.22848431 |
36 | glyoxylate metabolic process (GO:0046487) | 4.22073072 |
37 | * glutathione metabolic process (GO:0006749) | 4.21321375 |
38 | S-adenosylmethionine metabolic process (GO:0046500) | 4.20375560 |
39 | aromatic amino acid family catabolic process (GO:0009074) | 4.16135070 |
40 | blood coagulation, intrinsic pathway (GO:0007597) | 4.15977587 |
41 | reverse cholesterol transport (GO:0043691) | 4.10729160 |
42 | renal absorption (GO:0070293) | 4.10348417 |
43 | alpha-linolenic acid metabolic process (GO:0036109) | 4.04080048 |
44 | L-phenylalanine metabolic process (GO:0006558) | 4.03764864 |
45 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 4.03764864 |
46 | bile acid and bile salt transport (GO:0015721) | 4.03470740 |
47 | indole-containing compound catabolic process (GO:0042436) | 4.02459560 |
48 | indolalkylamine catabolic process (GO:0046218) | 4.02459560 |
49 | tryptophan catabolic process (GO:0006569) | 4.02459560 |
50 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 4.01410121 |
51 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 3.95866354 |
52 | ketone body metabolic process (GO:1902224) | 3.93389140 |
53 | vitamin biosynthetic process (GO:0009110) | 3.93044946 |
54 | bile acid biosynthetic process (GO:0006699) | 3.91008611 |
55 | arginine metabolic process (GO:0006525) | 3.84180242 |
56 | imidazole-containing compound metabolic process (GO:0052803) | 3.82716965 |
57 | regulation of bile acid biosynthetic process (GO:0070857) | 3.79852182 |
58 | relaxation of cardiac muscle (GO:0055119) | 3.78295239 |
59 | cysteine metabolic process (GO:0006534) | 3.74056028 |
60 | regulation of cholesterol metabolic process (GO:0090181) | 3.73749999 |
61 | tryptophan metabolic process (GO:0006568) | 3.73169067 |
62 | plasma lipoprotein particle remodeling (GO:0034369) | 3.70937871 |
63 | protein-lipid complex remodeling (GO:0034368) | 3.70937871 |
64 | macromolecular complex remodeling (GO:0034367) | 3.70937871 |
65 | energy homeostasis (GO:0097009) | 3.70919903 |
66 | phospholipid efflux (GO:0033700) | 3.70363930 |
67 | daunorubicin metabolic process (GO:0044597) | 3.69074163 |
68 | polyketide metabolic process (GO:0030638) | 3.69074163 |
69 | doxorubicin metabolic process (GO:0044598) | 3.69074163 |
70 | regulation of plasminogen activation (GO:0010755) | 3.66578650 |
71 | cofactor catabolic process (GO:0051187) | 3.65751003 |
72 | negative regulation of sterol transport (GO:0032372) | 3.64392116 |
73 | negative regulation of cholesterol transport (GO:0032375) | 3.64392116 |
74 | kynurenine metabolic process (GO:0070189) | 3.63393040 |
75 | monocarboxylic acid catabolic process (GO:0072329) | 3.50262562 |
76 | negative regulation of blood coagulation (GO:0030195) | 3.47779396 |
77 | negative regulation of hemostasis (GO:1900047) | 3.47779396 |
78 | 3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427) | 3.46300249 |
79 | purine ribonucleoside bisphosphate metabolic process (GO:0034035) | 3.46300249 |
80 | L-methionine salvage (GO:0071267) | 3.44751095 |
81 | L-methionine biosynthetic process (GO:0071265) | 3.44751095 |
82 | amino acid salvage (GO:0043102) | 3.44751095 |
83 | serine family amino acid metabolic process (GO:0009069) | 3.41432556 |
84 | fatty acid catabolic process (GO:0009062) | 3.40683183 |
85 | negative regulation of lipase activity (GO:0060192) | 3.39543229 |
86 | positive regulation of steroid metabolic process (GO:0045940) | 3.38920058 |
87 | quinone metabolic process (GO:1901661) | 3.38535130 |
88 | triglyceride homeostasis (GO:0070328) | 3.37283793 |
89 | acylglycerol homeostasis (GO:0055090) | 3.37283793 |
90 | regulation of cholesterol homeostasis (GO:2000188) | 3.36604986 |
91 | flavonoid metabolic process (GO:0009812) | 3.36593722 |
92 | regulation of fibrinolysis (GO:0051917) | 3.35677692 |
93 | primary alcohol catabolic process (GO:0034310) | 3.35079939 |
94 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 3.32917699 |
95 | phospholipid homeostasis (GO:0055091) | 3.32654207 |
96 | polyol transport (GO:0015791) | 3.32647897 |
97 | aminoglycoside antibiotic metabolic process (GO:0030647) | 3.31963402 |
98 | phenylpropanoid metabolic process (GO:0009698) | 3.23342968 |
99 | response to mercury ion (GO:0046689) | 3.22239076 |
100 | amino-acid betaine metabolic process (GO:0006577) | 3.22112390 |
101 | androgen biosynthetic process (GO:0006702) | 3.22053717 |
102 | negative regulation of coagulation (GO:0050819) | 3.22043198 |
103 | bile acid metabolic process (GO:0008206) | 3.21572055 |
104 | heme transport (GO:0015886) | 3.19051602 |
105 | tyrosine metabolic process (GO:0006570) | 3.18147582 |
106 | ribosomal small subunit assembly (GO:0000028) | 3.17681159 |
107 | amine catabolic process (GO:0009310) | 3.16927128 |
108 | cellular biogenic amine catabolic process (GO:0042402) | 3.16927128 |
109 | homocysteine metabolic process (GO:0050667) | 3.16867571 |
110 | nucleotide transmembrane transport (GO:1901679) | 3.16779841 |
111 | * xenobiotic metabolic process (GO:0006805) | 3.13591172 |
112 | primary alcohol metabolic process (GO:0034308) | 3.13216125 |
113 | artery smooth muscle contraction (GO:0014824) | 3.12237561 |
114 | carboxylic acid catabolic process (GO:0046395) | 3.12107755 |
115 | organic acid catabolic process (GO:0016054) | 3.12107755 |
116 | cholesterol efflux (GO:0033344) | 3.11456212 |
117 | branched-chain amino acid metabolic process (GO:0009081) | 3.11028137 |
118 | urea cycle (GO:0000050) | 3.09681098 |
119 | urea metabolic process (GO:0019627) | 3.09681098 |
120 | positive regulation of steroid biosynthetic process (GO:0010893) | 3.09537923 |
121 | linoleic acid metabolic process (GO:0043651) | 3.06434376 |
122 | protein activation cascade (GO:0072376) | 3.06391936 |
123 | killing of cells in other organism involved in symbiotic interaction (GO:0051883) | 3.05586486 |
124 | disruption of cells of other organism involved in symbiotic interaction (GO:0051818) | 3.05586486 |
125 | regulation of triglyceride catabolic process (GO:0010896) | 3.02690940 |
126 | aldehyde catabolic process (GO:0046185) | 3.02443011 |
127 | tonic smooth muscle contraction (GO:0014820) | 3.02072177 |
128 | response to caffeine (GO:0031000) | 3.01646985 |
129 | complement activation, alternative pathway (GO:0006957) | 3.00882345 |
130 | regulation of protein activation cascade (GO:2000257) | 2.98586031 |
131 | very-low-density lipoprotein particle assembly (GO:0034379) | 2.97715704 |
132 | plasma lipoprotein particle organization (GO:0071827) | 2.92758277 |
133 | sulfation (GO:0051923) | 2.90390260 |
134 | sulfate transmembrane transport (GO:1902358) | 2.89983287 |
135 | relaxation of muscle (GO:0090075) | 2.89310013 |
136 | protein carboxylation (GO:0018214) | 2.88273728 |
137 | peptidyl-glutamic acid carboxylation (GO:0017187) | 2.88273728 |
138 | response to dietary excess (GO:0002021) | 2.86670229 |
139 | L-serine metabolic process (GO:0006563) | 2.86608862 |
140 | negative regulation of fibrinolysis (GO:0051918) | 2.86320494 |
141 | cellular amino acid catabolic process (GO:0009063) | 2.85969134 |
142 | serine family amino acid catabolic process (GO:0009071) | 2.84892698 |
143 | aromatic amino acid family metabolic process (GO:0009072) | 2.84806326 |
144 | serine family amino acid biosynthetic process (GO:0009070) | 2.83758907 |
145 | drug transmembrane transport (GO:0006855) | 2.83607627 |
146 | nitrogen cycle metabolic process (GO:0071941) | 2.83298964 |
147 | acute-phase response (GO:0006953) | 2.82679791 |
148 | alpha-amino acid catabolic process (GO:1901606) | 2.79645634 |
149 | regulation of complement activation (GO:0030449) | 2.78337810 |
150 | regulation of secondary heart field cardioblast proliferation (GO:0003266) | 2.76206966 |
151 | regulation of cardioblast proliferation (GO:0003264) | 2.76206966 |
152 | peptide catabolic process (GO:0043171) | 2.76106472 |
153 | cellular modified amino acid catabolic process (GO:0042219) | 2.74072604 |
154 | toxin transport (GO:1901998) | 2.73244521 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 7.62489886 |
2 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 5.34862101 |
3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 5.34563946 |
4 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 4.59158248 |
5 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 4.51390414 |
6 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 4.37458841 |
7 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 3.74084799 |
8 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.66658986 |
9 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 3.47331077 |
10 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 3.27457425 |
11 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.18188595 |
12 | * NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 2.94288379 |
13 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.90467039 |
14 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.74886493 |
15 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.15121500 |
16 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.05605857 |
17 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.00161536 |
18 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.99019821 |
19 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.97609593 |
20 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.93735343 |
21 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.93687840 |
22 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.77548603 |
23 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.77388218 |
24 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70936467 |
25 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.67201962 |
26 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.66009712 |
27 | * NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.65324555 |
28 | * NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.65324555 |
29 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.59159055 |
30 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 1.58602189 |
31 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.55398211 |
32 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.53408042 |
33 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.50788503 |
34 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.49271667 |
35 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.48216956 |
36 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.46185486 |
37 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.44945871 |
38 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.44836849 |
39 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.44001300 |
40 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.42559909 |
41 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.41527263 |
42 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.38704382 |
43 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.37673963 |
44 | CBP_21632823_ChIP-Seq_H3396_Human | 1.37072254 |
45 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.37057911 |
46 | AR_20517297_ChIP-Seq_VCAP_Human | 1.36927740 |
47 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.36716362 |
48 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.33775290 |
49 | * SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.33486612 |
50 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.30894151 |
51 | SOX2_21211035_ChIP-Seq_LN229_Human | 1.29574249 |
52 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 1.28084204 |
53 | * Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.26247386 |
54 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.25308028 |
55 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.25093038 |
56 | * BCL6_27268052_Chip-Seq_Bcells_Human | 1.25038471 |
57 | SA1_27219007_Chip-Seq_Bcells_Human | 1.24614261 |
58 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.24167380 |
59 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.23862235 |
60 | * CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.22737859 |
61 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.22145618 |
62 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.19755378 |
63 | * PHF8_20622853_ChIP-Seq_HELA_Human | 1.19682011 |
64 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.19443595 |
65 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 1.19241326 |
66 | * GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.19018211 |
67 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.18059424 |
68 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.17815023 |
69 | * FOXH1_21741376_ChIP-Seq_EPCs_Human | 1.17450313 |
70 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.17130534 |
71 | CEBPB_22108803_ChIP-Seq_LS180_Human | 1.16984931 |
72 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.16648390 |
73 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.16380915 |
74 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.15839039 |
75 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.15418133 |
76 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.14652768 |
77 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.13749887 |
78 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.10637347 |
79 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.09183819 |
80 | NCOR_22424771_ChIP-Seq_293T_Human | 1.09013223 |
81 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.08843453 |
82 | * PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.08042864 |
83 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.07402348 |
84 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.06536474 |
85 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.06409473 |
86 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.05704246 |
87 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.05704246 |
88 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.05427940 |
89 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.04009607 |
90 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.02232291 |
91 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.01963943 |
92 | * RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.01458317 |
93 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.00917908 |
94 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.00613679 |
95 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.00518026 |
96 | * EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.00249698 |
97 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.99079791 |
98 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.99079791 |
99 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.99039254 |
100 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.98889706 |
101 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.98227553 |
102 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.97350996 |
103 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.96784038 |
104 | P300_27268052_Chip-Seq_Bcells_Human | 0.96709278 |
105 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.96607979 |
106 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.96394362 |
107 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.96394362 |
108 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.96394362 |
109 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.96147763 |
110 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.95990459 |
111 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.95476057 |
112 | NFYA_21822215_ChIP-Seq_K562_Human | 0.95186258 |
113 | * EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.95145576 |
114 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.94893095 |
115 | CJUN_26792858_Chip-Seq_BT549_Human | 0.94504253 |
116 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.94081064 |
117 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.93859163 |
118 | * CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.93300271 |
119 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.93166100 |
120 | * CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.92493686 |
121 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.91889467 |
122 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.91815759 |
123 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.91792248 |
124 | GATA1_22025678_ChIP-Seq_K562_Human | 0.91292602 |
125 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.91289785 |
126 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.91134821 |
127 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.90485785 |
128 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.90328571 |
129 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.89672201 |
130 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.88468394 |
131 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.88307621 |
132 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.87400733 |
133 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.86815434 |
134 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.86063396 |
135 | * RBPJ_21746931_ChIP-Seq_IB4_Human | 0.84961546 |
136 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.84493915 |
137 | GATA3_21867929_ChIP-Seq_CD8_Mouse | 0.84113665 |
138 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.84093178 |
139 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.84007766 |
140 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.83535764 |
141 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.83381802 |
142 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.82546453 |
143 | * SPI1_20517297_ChIP-Seq_HL60_Human | 0.82436579 |
144 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 0.82084464 |
145 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.82047079 |
146 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.79931913 |
147 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.79731513 |
148 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.79310611 |
149 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.78502885 |
150 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.78415011 |
151 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.77557065 |
152 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.77367714 |
153 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.76688096 |
154 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.76688096 |
155 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.74081459 |
156 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 0.72371458 |
157 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.72265604 |
158 | RXR_22108803_ChIP-Seq_LS180_Human | 0.71990574 |
159 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 0.71745300 |
160 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.71173182 |
161 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.70651793 |
162 | TP63_23658742_ChIP-Seq_EP156T_Human | 0.69184639 |
163 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.68435547 |
164 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.67810974 |
165 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.67547485 |
166 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.67542935 |
167 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.66906964 |
168 | KLF5_25053715_ChIP-Seq_YYC3_Human | 0.65989115 |
169 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.65904813 |
170 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.64661105 |
171 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.64580496 |
172 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.63773329 |
173 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.63539528 |
174 | * P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.60793155 |
175 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 0.59759207 |
176 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.58840898 |
177 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 0.58608080 |
178 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.58576373 |
179 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.58128201 |
180 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.58008647 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 5.28044221 |
2 | MP0005365_abnormal_bile_salt | 4.87164329 |
3 | * MP0008875_abnormal_xenobiotic_pharmacok | 4.48708386 |
4 | MP0005085_abnormal_gallbladder_physiolo | 4.42225982 |
5 | MP0005360_urolithiasis | 4.33951977 |
6 | MP0008789_abnormal_olfactory_epithelium | 3.89543834 |
7 | MP0005367_renal/urinary_system_phenotyp | 3.73729822 |
8 | MP0000516_abnormal_urinary_system | 3.73729822 |
9 | MP0010386_abnormal_urinary_bladder | 3.69717439 |
10 | MP0005499_abnormal_olfactory_system | 3.23971928 |
11 | MP0005394_taste/olfaction_phenotype | 3.23971928 |
12 | MP0009840_abnormal_foam_cell | 3.13223891 |
13 | MP0003186_abnormal_redox_activity | 3.00597140 |
14 | MP0010329_abnormal_lipoprotein_level | 2.91700074 |
15 | MP0003806_abnormal_nucleotide_metabolis | 2.55214848 |
16 | MP0002877_abnormal_melanocyte_morpholog | 2.52820026 |
17 | MP0010030_abnormal_orbit_morphology | 2.51333131 |
18 | MP0002254_reproductive_system_inflammat | 2.46099571 |
19 | MP0005083_abnormal_biliary_tract | 2.28181494 |
20 | MP0010368_abnormal_lymphatic_system | 2.24432313 |
21 | MP0003252_abnormal_bile_duct | 2.20638970 |
22 | MP0005332_abnormal_amino_acid | 2.16097633 |
23 | MP0003690_abnormal_glial_cell | 2.14403816 |
24 | MP0000678_abnormal_parathyroid_gland | 2.01558366 |
25 | MP0003195_calcinosis | 1.99982798 |
26 | MP0004019_abnormal_vitamin_homeostasis | 1.98961291 |
27 | MP0002132_abnormal_respiratory_system | 1.94449636 |
28 | MP0003191_abnormal_cellular_cholesterol | 1.93833200 |
29 | MP0004043_abnormal_pH_regulation | 1.93691817 |
30 | MP0000566_synostosis | 1.90157317 |
31 | MP0009053_abnormal_anal_canal | 1.87184897 |
32 | MP0003868_abnormal_feces_composition | 1.67536630 |
33 | MP0001666_abnormal_nutrient_absorption | 1.62771975 |
34 | MP0002653_abnormal_ependyma_morphology | 1.49838042 |
35 | MP0002118_abnormal_lipid_homeostasis | 1.48540784 |
36 | MP0003724_increased_susceptibility_to | 1.42948498 |
37 | MP0005319_abnormal_enzyme/_coenzyme | 1.37024745 |
38 | MP0004142_abnormal_muscle_tone | 1.34109752 |
39 | MP0001764_abnormal_homeostasis | 1.31744857 |
40 | MP0005408_hypopigmentation | 1.29177925 |
41 | MP0006292_abnormal_olfactory_placode | 1.27714834 |
42 | MP0000609_abnormal_liver_physiology | 1.26462698 |
43 | MP0002837_dystrophic_cardiac_calcinosis | 1.24795823 |
44 | MP0001346_abnormal_lacrimal_gland | 1.24197891 |
45 | MP0002295_abnormal_pulmonary_circulatio | 1.22565147 |
46 | MP0000762_abnormal_tongue_morphology | 1.22121542 |
47 | MP0009379_abnormal_foot_pigmentation | 1.19944755 |
48 | MP0002233_abnormal_nose_morphology | 1.19897499 |
49 | MP0006036_abnormal_mitochondrial_physio | 1.16775679 |
50 | MP0002102_abnormal_ear_morphology | 1.16289740 |
51 | MP0005647_abnormal_sex_gland | 1.12774492 |
52 | MP0009643_abnormal_urine_homeostasis | 1.09748209 |
53 | MP0002090_abnormal_vision | 1.09046737 |
54 | MP0001501_abnormal_sleep_pattern | 1.08030341 |
55 | MP0001756_abnormal_urination | 1.07899924 |
56 | MP0003075_altered_response_to | 1.06839413 |
57 | MP0003705_abnormal_hypodermis_morpholog | 1.03624633 |
58 | MP0002249_abnormal_larynx_morphology | 1.02538810 |
59 | MP0009764_decreased_sensitivity_to | 1.02415151 |
60 | MP0005164_abnormal_response_to | 0.99498524 |
61 | MP0003879_abnormal_hair_cell | 0.98673688 |
62 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.96829554 |
63 | MP0009785_altered_susceptibility_to | 0.94826516 |
64 | MP0004883_abnormal_blood_vessel | 0.93617278 |
65 | MP0002098_abnormal_vibrissa_morphology | 0.93414132 |
66 | MP0004782_abnormal_surfactant_physiolog | 0.93061074 |
67 | MP0005636_abnormal_mineral_homeostasis | 0.92442852 |
68 | MP0001661_extended_life_span | 0.92099367 |
69 | MP0003638_abnormal_response/metabolism_ | 0.91575118 |
70 | MP0002876_abnormal_thyroid_physiology | 0.89998623 |
71 | MP0005084_abnormal_gallbladder_morpholo | 0.88438238 |
72 | MP0009763_increased_sensitivity_to | 0.87370706 |
73 | MP0002282_abnormal_trachea_morphology | 0.85778762 |
74 | MP0002138_abnormal_hepatobiliary_system | 0.85258571 |
75 | MP0000049_abnormal_middle_ear | 0.84867905 |
76 | MP0000534_abnormal_ureter_morphology | 0.84091276 |
77 | MP0009765_abnormal_xenobiotic_induced | 0.81890189 |
78 | MP0000613_abnormal_salivary_gland | 0.81112534 |
79 | MP0001986_abnormal_taste_sensitivity | 0.80871451 |
80 | MP0005377_hearing/vestibular/ear_phenot | 0.80149162 |
81 | MP0003878_abnormal_ear_physiology | 0.80149162 |
82 | MP0001853_heart_inflammation | 0.80100040 |
83 | MP0005248_abnormal_Harderian_gland | 0.78666736 |
84 | MP0004264_abnormal_extraembryonic_tissu | 0.78567186 |
85 | MP0006072_abnormal_retinal_apoptosis | 0.77820867 |
86 | MP0005646_abnormal_pituitary_gland | 0.76702112 |
87 | MP0003656_abnormal_erythrocyte_physiolo | 0.76390812 |
88 | * MP0008872_abnormal_physiological_respon | 0.76158377 |
89 | MP0003279_aneurysm | 0.76022740 |
90 | MP0003011_delayed_dark_adaptation | 0.75130754 |
91 | MP0005376_homeostasis/metabolism_phenot | 0.73708928 |
92 | MP0006082_CNS_inflammation | 0.73530431 |
93 | MP0005551_abnormal_eye_electrophysiolog | 0.72257794 |
94 | MP0005451_abnormal_body_composition | 0.70693473 |
95 | MP0001485_abnormal_pinna_reflex | 0.70462857 |
96 | MP0005166_decreased_susceptibility_to | 0.68014603 |
97 | MP0004885_abnormal_endolymph | 0.67679256 |
98 | MP0003453_abnormal_keratinocyte_physiol | 0.67417788 |
99 | MP0001984_abnormal_olfaction | 0.67000296 |
100 | MP0001440_abnormal_grooming_behavior | 0.65058816 |
101 | MP0002136_abnormal_kidney_physiology | 0.64883418 |
102 | MP0005023_abnormal_wound_healing | 0.64524652 |
103 | MP0003943_abnormal_hepatobiliary_system | 0.64255425 |
104 | MP0000598_abnormal_liver_morphology | 0.64083496 |
105 | MP0003436_decreased_susceptibility_to | 0.62799086 |
106 | MP0005671_abnormal_response_to | 0.61413991 |
107 | MP0005266_abnormal_metabolism | 0.61229001 |
108 | MP0001502_abnormal_circadian_rhythm | 0.59455510 |
109 | MP0000026_abnormal_inner_ear | 0.59158841 |
110 | MP0002928_abnormal_bile_duct | 0.57900530 |
111 | MP0001177_atelectasis | 0.57720887 |
112 | MP0004147_increased_porphyrin_level | 0.57510847 |
113 | MP0001963_abnormal_hearing_physiology | 0.57509903 |
114 | MP0002971_abnormal_brown_adipose | 0.57159373 |
115 | MP0002078_abnormal_glucose_homeostasis | 0.57027715 |
116 | MP0002060_abnormal_skin_morphology | 0.56871055 |
117 | MP0005670_abnormal_white_adipose | 0.54928721 |
118 | MP0005464_abnormal_platelet_physiology | 0.54608050 |
119 | MP0000604_amyloidosis | 0.54321634 |
120 | MP0009642_abnormal_blood_homeostasis | 0.52575246 |
121 | MP0008469_abnormal_protein_level | 0.52327970 |
122 | MP0005387_immune_system_phenotype | 0.51842295 |
123 | MP0001790_abnormal_immune_system | 0.51842295 |
124 | MP0005397_hematopoietic_system_phenotyp | 0.50946124 |
125 | MP0001545_abnormal_hematopoietic_system | 0.50946124 |
126 | MP0001835_abnormal_antigen_presentation | 0.50483556 |
127 | MP0009250_abnormal_appendicular_skeleto | 0.50403725 |
128 | MP0005535_abnormal_body_temperature | 0.49774270 |
129 | MP0009115_abnormal_fat_cell | 0.49727749 |
130 | MP0009697_abnormal_copulation | 0.49499491 |
131 | MP0009780_abnormal_chondrocyte_physiolo | 0.49299577 |
132 | MP0004742_abnormal_vestibular_system | 0.48755536 |
133 | MP0000230_abnormal_systemic_arterial | 0.48737909 |
134 | MP0001845_abnormal_inflammatory_respons | 0.48521167 |
135 | MP0002736_abnormal_nociception_after | 0.47750412 |
136 | MP0001800_abnormal_humoral_immune | 0.47059781 |
137 | MP0000685_abnormal_immune_system | 0.46428892 |
138 | * MP0001905_abnormal_dopamine_level | 0.46271113 |
139 | MP0000749_muscle_degeneration | 0.44214236 |
140 | MP0001542_abnormal_bone_strength | 0.44036977 |
141 | MP0005448_abnormal_energy_balance | 0.43951537 |
142 | MP0005025_abnormal_response_to | 0.41712764 |
143 | MP0001765_abnormal_ion_homeostasis | 0.41266924 |
144 | MP0005334_abnormal_fat_pad | 0.41136767 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 5.87323370 |
2 | Stomach cancer (HP:0012126) | 4.97343042 |
3 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 4.55957596 |
4 | Intrahepatic cholestasis (HP:0001406) | 4.52099488 |
5 | Deep venous thrombosis (HP:0002625) | 4.40468609 |
6 | Xanthomatosis (HP:0000991) | 4.32721119 |
7 | Fat malabsorption (HP:0002630) | 4.26407697 |
8 | Steatorrhea (HP:0002570) | 4.19512447 |
9 | Bifid scrotum (HP:0000048) | 4.12391791 |
10 | Prolonged partial thromboplastin time (HP:0003645) | 4.00893196 |
11 | Hyperlipoproteinemia (HP:0010980) | 3.74899700 |
12 | Lip pit (HP:0100267) | 3.71219508 |
13 | Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173) | 3.66203590 |
14 | Epidermoid cyst (HP:0200040) | 3.53015628 |
15 | Synostosis involving the elbow (HP:0003938) | 3.50547564 |
16 | Humeroradial synostosis (HP:0003041) | 3.50547564 |
17 | Hyperglycinuria (HP:0003108) | 3.45089256 |
18 | Hypobetalipoproteinemia (HP:0003563) | 3.41122524 |
19 | Joint hemorrhage (HP:0005261) | 3.37088655 |
20 | Acute encephalopathy (HP:0006846) | 3.30487812 |
21 | Alveolar cell carcinoma (HP:0006519) | 3.28331435 |
22 | Cerebral edema (HP:0002181) | 3.26255263 |
23 | Abnormality of the middle phalanges of the toes (HP:0010183) | 3.25120995 |
24 | Complement deficiency (HP:0004431) | 3.19159765 |
25 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 3.16544224 |
26 | Acute necrotizing encephalopathy (HP:0006965) | 3.14538431 |
27 | Hypoglycemic coma (HP:0001325) | 3.12433306 |
28 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.11717466 |
29 | Renal tubular acidosis (HP:0001947) | 3.10643441 |
30 | Hypoalphalipoproteinemia (HP:0003233) | 3.10528101 |
31 | Glycosuria (HP:0003076) | 3.07672873 |
32 | Abnormality of urine glucose concentration (HP:0011016) | 3.07672873 |
33 | Ketosis (HP:0001946) | 3.07009742 |
34 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 3.06840215 |
35 | Rickets (HP:0002748) | 3.05499189 |
36 | Hypolipoproteinemia (HP:0010981) | 3.00303849 |
37 | Abnormality of glycine metabolism (HP:0010895) | 2.99794452 |
38 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.99794452 |
39 | Mitochondrial inheritance (HP:0001427) | 2.98816923 |
40 | Hyperammonemia (HP:0001987) | 2.93654170 |
41 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.93151229 |
42 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.92526279 |
43 | Hepatic necrosis (HP:0002605) | 2.91667628 |
44 | Reticulocytopenia (HP:0001896) | 2.89050370 |
45 | Neoplasm of the tracheobronchial system (HP:0100552) | 2.88923134 |
46 | Hepatocellular necrosis (HP:0001404) | 2.86650592 |
47 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 2.81285314 |
48 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.77194124 |
49 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.76300086 |
50 | Glomerulonephritis (HP:0000099) | 2.75422210 |
51 | Myocardial infarction (HP:0001658) | 2.75071398 |
52 | Abnormality of methionine metabolism (HP:0010901) | 2.74396886 |
53 | Lethargy (HP:0001254) | 2.72951309 |
54 | Hyperphosphaturia (HP:0003109) | 2.72797554 |
55 | Ketoacidosis (HP:0001993) | 2.72357738 |
56 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 2.71905794 |
57 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 2.71605732 |
58 | Dicarboxylic aciduria (HP:0003215) | 2.71226640 |
59 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.71226640 |
60 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.69622167 |
61 | Right ventricular cardiomyopathy (HP:0011663) | 2.69257314 |
62 | Proximal tubulopathy (HP:0000114) | 2.66423888 |
63 | Abnormality of the common coagulation pathway (HP:0010990) | 2.66118954 |
64 | Distal lower limb muscle weakness (HP:0009053) | 2.65814018 |
65 | Renal Fanconi syndrome (HP:0001994) | 2.60550453 |
66 | Systemic lupus erythematosus (HP:0002725) | 2.57145566 |
67 | Hyperglycinemia (HP:0002154) | 2.56347776 |
68 | Progressive macrocephaly (HP:0004481) | 2.53931101 |
69 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 2.53741464 |
70 | 3-Methylglutaconic aciduria (HP:0003535) | 2.50607031 |
71 | Hypercholesterolemia (HP:0003124) | 2.46116886 |
72 | Abnormality of complement system (HP:0005339) | 2.45479156 |
73 | Conjugated hyperbilirubinemia (HP:0002908) | 2.40395052 |
74 | Nephritis (HP:0000123) | 2.38440645 |
75 | Short hallux (HP:0010109) | 2.35373400 |
76 | Osteomalacia (HP:0002749) | 2.35110899 |
77 | Renal cortical cysts (HP:0000803) | 2.35022793 |
78 | Fibular aplasia (HP:0002990) | 2.33756603 |
79 | Lipid accumulation in hepatocytes (HP:0006561) | 2.33566257 |
80 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.31300046 |
81 | Aplasia of the phalanges of the hand (HP:0009802) | 2.31300046 |
82 | Aplasia involving bones of the extremities (HP:0009825) | 2.31300046 |
83 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 2.27590443 |
84 | Polycythemia (HP:0001901) | 2.26729760 |
85 | Prostate neoplasm (HP:0100787) | 2.26192247 |
86 | Delayed CNS myelination (HP:0002188) | 2.24707863 |
87 | Enlarged epiphyses (HP:0010580) | 2.24595292 |
88 | Increased CSF lactate (HP:0002490) | 2.24083531 |
89 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.23642791 |
90 | Abnormality of vitamin metabolism (HP:0100508) | 2.22209396 |
91 | Generalized aminoaciduria (HP:0002909) | 2.21319609 |
92 | Abnormal biliary tract physiology (HP:0012439) | 2.21068229 |
93 | Bile duct proliferation (HP:0001408) | 2.21068229 |
94 | Parakeratosis (HP:0001036) | 2.20830979 |
95 | Abnormal hemoglobin (HP:0011902) | 2.20779778 |
96 | Hepatocellular carcinoma (HP:0001402) | 2.19258091 |
97 | Increased muscle lipid content (HP:0009058) | 2.17793649 |
98 | Reduced antithrombin III activity (HP:0001976) | 2.16918031 |
99 | Aplasia/Hypoplasia of the hallux (HP:0008362) | 2.13283249 |
100 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 2.10521089 |
101 | Oligomenorrhea (HP:0000876) | 2.09193335 |
102 | Esophageal varix (HP:0002040) | 2.07569237 |
103 | Hyperbilirubinemia (HP:0002904) | 2.07002351 |
104 | Alopecia of scalp (HP:0002293) | 2.06390392 |
105 | Amyloidosis (HP:0011034) | 2.04648524 |
106 | Hypophosphatemic rickets (HP:0004912) | 2.04385717 |
107 | Spastic diplegia (HP:0001264) | 2.03264229 |
108 | Spontaneous abortion (HP:0005268) | 2.02710062 |
109 | Vomiting (HP:0002013) | 2.02124477 |
110 | Vascular calcification (HP:0004934) | 2.01211407 |
111 | Femoral bowing (HP:0002980) | 1.99048890 |
112 | Macrocytic anemia (HP:0001972) | 1.99038562 |
113 | True hermaphroditism (HP:0010459) | 1.99001284 |
114 | Metabolic acidosis (HP:0001942) | 1.98993710 |
115 | Abnormality of the intrinsic pathway (HP:0010989) | 1.98884090 |
116 | Rhabdomyolysis (HP:0003201) | 1.98487330 |
117 | Hyperventilation (HP:0002883) | 1.98332376 |
118 | Purpura (HP:0000979) | 1.96938651 |
119 | Hypochromic microcytic anemia (HP:0004840) | 1.96678216 |
120 | Mitral stenosis (HP:0001718) | 1.95873669 |
121 | Irritability (HP:0000737) | 1.94925308 |
122 | Abnormal urine phosphate concentration (HP:0012599) | 1.94294386 |
123 | Pseudobulbar signs (HP:0002200) | 1.93871093 |
124 | Increased intramyocellular lipid droplets (HP:0012240) | 1.93010425 |
125 | Abnormality of purine metabolism (HP:0004352) | 1.92840057 |
126 | Flat acetabular roof (HP:0003180) | 1.92009595 |
127 | Methylmalonic acidemia (HP:0002912) | 1.91004514 |
128 | Increased hepatocellular lipid droplets (HP:0006565) | 1.90494766 |
129 | Abnormality of the 2nd finger (HP:0004100) | 1.89392241 |
130 | Stenosis of the external auditory canal (HP:0000402) | 1.88093023 |
131 | Abnormality of nucleobase metabolism (HP:0010932) | 1.87717359 |
132 | Pancreatitis (HP:0001733) | 1.87611490 |
133 | Gout (HP:0001997) | 1.87389055 |
134 | Abnormality of serum amino acid levels (HP:0003112) | 1.87271265 |
135 | Pancreatic fibrosis (HP:0100732) | 1.85827546 |
136 | Renal tubular dysfunction (HP:0000124) | 1.85494003 |
137 | Bowed forearm bones (HP:0003956) | 1.84740269 |
138 | Bowing of the arm (HP:0006488) | 1.84740269 |
139 | Mesomelia (HP:0003027) | 1.81981447 |
140 | Abnormal tarsal ossification (HP:0008369) | 1.80069018 |
141 | Tarsal synostosis (HP:0008368) | 1.79738199 |
142 | Cerebral palsy (HP:0100021) | 1.79316150 |
143 | Methylmalonic aciduria (HP:0012120) | 1.78671819 |
144 | Exertional dyspnea (HP:0002875) | 1.78429306 |
145 | Cardiovascular calcification (HP:0011915) | 1.72874084 |
146 | Abnormal pupillary function (HP:0007686) | 1.72654024 |
147 | Congenital, generalized hypertrichosis (HP:0004540) | 1.71765474 |
148 | Lactic acidosis (HP:0003128) | 1.71420475 |
149 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.67196936 |
150 | Myoglobinuria (HP:0002913) | 1.65865488 |
151 | Pancreatic cysts (HP:0001737) | 1.64758380 |
152 | Increased serum pyruvate (HP:0003542) | 1.64242044 |
153 | Joint swelling (HP:0001386) | 1.64225649 |
154 | Opisthotonus (HP:0002179) | 1.62744805 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 4.03852381 |
2 | ZAK | 3.71241996 |
3 | VRK2 | 3.58276963 |
4 | RIPK1 | 3.33511000 |
5 | MAP3K3 | 3.30484351 |
6 | MAPK15 | 2.90455033 |
7 | CDK19 | 2.76015744 |
8 | GRK5 | 2.36417136 |
9 | OBSCN | 2.32032526 |
10 | ERN1 | 2.29087024 |
11 | SIK1 | 2.25682714 |
12 | FRK | 2.23628813 |
13 | INSRR | 2.19118384 |
14 | MAP2K3 | 2.15340970 |
15 | EPHB1 | 2.10263924 |
16 | BRSK2 | 2.07090438 |
17 | NME1 | 2.06762641 |
18 | EPHB2 | 1.91145085 |
19 | VRK1 | 1.81945348 |
20 | ERBB4 | 1.76521328 |
21 | MAP3K14 | 1.76136155 |
22 | MAP3K2 | 1.73714797 |
23 | FGFR4 | 1.73143594 |
24 | SGK2 | 1.72005449 |
25 | MAP4K1 | 1.70979664 |
26 | EPHA3 | 1.69045147 |
27 | TAF1 | 1.67431810 |
28 | MAP3K12 | 1.65133879 |
29 | NLK | 1.62415423 |
30 | MST4 | 1.61427576 |
31 | HIPK2 | 1.58072067 |
32 | BMPR2 | 1.56471926 |
33 | NME2 | 1.55472337 |
34 | MAP2K2 | 1.53400466 |
35 | TAOK2 | 1.50669228 |
36 | STK16 | 1.46897260 |
37 | SGK3 | 1.45887304 |
38 | MYLK | 1.40898635 |
39 | DAPK3 | 1.39076815 |
40 | DYRK2 | 1.37902034 |
41 | TNIK | 1.32871533 |
42 | SGK223 | 1.29154482 |
43 | SGK494 | 1.29154482 |
44 | RPS6KB2 | 1.28118365 |
45 | RPS6KA4 | 1.26027369 |
46 | PINK1 | 1.21916388 |
47 | PBK | 1.21423154 |
48 | IKBKE | 1.18386592 |
49 | ARAF | 1.16092587 |
50 | ADRBK2 | 1.12218353 |
51 | KIT | 1.10204491 |
52 | CDK6 | 1.08469169 |
53 | TESK1 | 1.08446845 |
54 | IRAK3 | 1.04945558 |
55 | PDK2 | 1.03645654 |
56 | MAP4K2 | 1.02072988 |
57 | TAOK3 | 1.01318770 |
58 | TNK2 | 1.01180034 |
59 | MAPK7 | 1.00423864 |
60 | MST1R | 0.98901131 |
61 | MAP2K7 | 0.98155762 |
62 | DAPK1 | 0.97912190 |
63 | GSK3A | 0.97838989 |
64 | TXK | 0.95416994 |
65 | NEK6 | 0.95329838 |
66 | PRKCQ | 0.94590822 |
67 | CSF1R | 0.92890577 |
68 | LMTK2 | 0.91363429 |
69 | WNK3 | 0.91228524 |
70 | DYRK1B | 0.89119691 |
71 | NEK9 | 0.88487389 |
72 | MUSK | 0.88380023 |
73 | JAK1 | 0.86906629 |
74 | STK38L | 0.85701958 |
75 | ERBB2 | 0.85357594 |
76 | TYK2 | 0.85245647 |
77 | PHKG2 | 0.84413100 |
78 | PHKG1 | 0.84413100 |
79 | EPHA2 | 0.83837938 |
80 | CAMK4 | 0.82032619 |
81 | TLK1 | 0.79568271 |
82 | PAK3 | 0.78817234 |
83 | MAP2K6 | 0.75682977 |
84 | PTK6 | 0.74399608 |
85 | DDR2 | 0.73912150 |
86 | JAK2 | 0.73655297 |
87 | KDR | 0.73136158 |
88 | DAPK2 | 0.72679054 |
89 | JAK3 | 0.72030504 |
90 | MAPKAPK3 | 0.71926003 |
91 | LRRK2 | 0.71876423 |
92 | CHUK | 0.69935755 |
93 | MAP2K1 | 0.69845030 |
94 | IKBKB | 0.69644800 |
95 | LATS1 | 0.69526020 |
96 | MAPK12 | 0.68393499 |
97 | TAOK1 | 0.66593469 |
98 | IRAK4 | 0.66133776 |
99 | BRAF | 0.63295492 |
100 | PRKACA | 0.63079811 |
101 | MAP3K11 | 0.62636626 |
102 | WEE1 | 0.61177207 |
103 | STK4 | 0.60618911 |
104 | IGF1R | 0.59310258 |
105 | MAP2K4 | 0.59149710 |
106 | IRAK1 | 0.59128718 |
107 | RPS6KA6 | 0.58802382 |
108 | PRKCG | 0.57587745 |
109 | ADRBK1 | 0.57117208 |
110 | PRKACG | 0.56261200 |
111 | PRKG1 | 0.56056896 |
112 | FGFR2 | 0.55632060 |
113 | MAPK4 | 0.55299217 |
114 | STK10 | 0.54409481 |
115 | TTN | 0.53622356 |
116 | ABL2 | 0.53514133 |
117 | TBK1 | 0.53452525 |
118 | PIK3CG | 0.52010957 |
119 | STK38 | 0.51336314 |
120 | SYK | 0.50629247 |
121 | MAP3K4 | 0.49352626 |
122 | TGFBR1 | 0.49294188 |
123 | CAMK2G | 0.47164104 |
124 | FER | 0.47055326 |
125 | TIE1 | 0.46307801 |
126 | NUAK1 | 0.45559857 |
127 | MARK3 | 0.44999061 |
128 | RPS6KC1 | 0.43511543 |
129 | RPS6KL1 | 0.43511543 |
130 | PRKCA | 0.43470196 |
131 | ILK | 0.43171573 |
132 | AKT3 | 0.43109462 |
133 | PIM2 | 0.42684462 |
134 | MAP3K13 | 0.42674731 |
135 | LYN | 0.42132358 |
136 | MATK | 0.42108615 |
137 | PRKCD | 0.41611933 |
138 | MAPKAPK2 | 0.41208213 |
139 | RPS6KA2 | 0.41089761 |
140 | TEC | 0.40609197 |
141 | LIMK1 | 0.40559356 |
142 | PAK1 | 0.40289408 |
143 | MAP3K5 | 0.39571855 |
144 | EPHA4 | 0.38993026 |
145 | BRSK1 | 0.38783208 |
146 | CAMK1 | 0.37724206 |
147 | CDK9 | 0.37297286 |
148 | MOS | 0.37271209 |
149 | PRKCE | 0.37253449 |
150 | BMPR1B | 0.36944641 |
151 | AKT2 | 0.34111204 |
152 | MAPKAPK5 | 0.33725636 |
153 | MAP3K1 | 0.33648486 |
154 | ROCK1 | 0.33529519 |
155 | BTK | 0.31348182 |
156 | GRK1 | 0.31074176 |
157 | CSNK1A1 | 0.30445085 |
158 | ERBB3 | 0.29847481 |
159 | MAPK3 | 0.29426141 |
160 | MET | 0.26904882 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 4.45971386 |
2 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 4.17214279 |
3 | * Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 4.01871362 |
4 | * Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 4.01546686 |
5 | * Chemical carcinogenesis_Homo sapiens_hsa05204 | 3.65399563 |
6 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 3.34127890 |
7 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.04132443 |
8 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.96782864 |
9 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.57129695 |
10 | Retinol metabolism_Homo sapiens_hsa00830 | 2.07754898 |
11 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.05297806 |
12 | * Glutathione metabolism_Homo sapiens_hsa00480 | 2.04824605 |
13 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.96829812 |
14 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.96529268 |
15 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.92453496 |
16 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.85596200 |
17 | Sulfur relay system_Homo sapiens_hsa04122 | 1.83557171 |
18 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.79306576 |
19 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.78730893 |
20 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.78176274 |
21 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.78037585 |
22 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.77203511 |
23 | Peroxisome_Homo sapiens_hsa04146 | 1.73945588 |
24 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.69147561 |
25 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.68819281 |
26 | Histidine metabolism_Homo sapiens_hsa00340 | 1.60279040 |
27 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.55500605 |
28 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.54309457 |
29 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.47411906 |
30 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.46288697 |
31 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.39336607 |
32 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.38754213 |
33 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.36026977 |
34 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.33689877 |
35 | Ribosome_Homo sapiens_hsa03010 | 1.28090448 |
36 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.27840292 |
37 | Bile secretion_Homo sapiens_hsa04976 | 1.22144500 |
38 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.15954956 |
39 | Parkinsons disease_Homo sapiens_hsa05012 | 1.10975540 |
40 | Galactose metabolism_Homo sapiens_hsa00052 | 1.10105733 |
41 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.03356812 |
42 | ABC transporters_Homo sapiens_hsa02010 | 0.97747056 |
43 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.97347097 |
44 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.95510824 |
45 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.91330259 |
46 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.90049485 |
47 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.89353673 |
48 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.88174308 |
49 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.85018948 |
50 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.84927287 |
51 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.75474756 |
52 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.72833242 |
53 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.72540522 |
54 | Circadian rhythm_Homo sapiens_hsa04710 | 0.72033701 |
55 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.70702828 |
56 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.68200889 |
57 | Proteasome_Homo sapiens_hsa03050 | 0.65291211 |
58 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.64677992 |
59 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.63993500 |
60 | Asthma_Homo sapiens_hsa05310 | 0.63632069 |
61 | Alzheimers disease_Homo sapiens_hsa05010 | 0.62896958 |
62 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.62185366 |
63 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.60093769 |
64 | Prion diseases_Homo sapiens_hsa05020 | 0.59163899 |
65 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.57962367 |
66 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.57331035 |
67 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.57017172 |
68 | Carbon metabolism_Homo sapiens_hsa01200 | 0.56934573 |
69 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.54554005 |
70 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.54461219 |
71 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.50375286 |
72 | Huntingtons disease_Homo sapiens_hsa05016 | 0.50111203 |
73 | Allograft rejection_Homo sapiens_hsa05330 | 0.48979187 |
74 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.46866314 |
75 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.46670816 |
76 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.46154925 |
77 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.44821279 |
78 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.44431042 |
79 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.39406349 |
80 | Lysine degradation_Homo sapiens_hsa00310 | 0.36510012 |
81 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.36222205 |
82 | Insulin resistance_Homo sapiens_hsa04931 | 0.32058263 |
83 | Mineral absorption_Homo sapiens_hsa04978 | 0.30437863 |
84 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.29975519 |
85 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.28486944 |
86 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.27210054 |
87 | Metabolic pathways_Homo sapiens_hsa01100 | 0.27203524 |
88 | Protein export_Homo sapiens_hsa03060 | 0.27124598 |
89 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.26459915 |
90 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.26224895 |
91 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.23655984 |
92 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.23254528 |
93 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.22197610 |
94 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.19275956 |
95 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.18254337 |
96 | RNA polymerase_Homo sapiens_hsa03020 | 0.16736069 |
97 | Pertussis_Homo sapiens_hsa05133 | 0.16236662 |
98 | Phototransduction_Homo sapiens_hsa04744 | 0.14323373 |
99 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.13895853 |
100 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.11734631 |
101 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.11132021 |
102 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.11123608 |
103 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.10066907 |
104 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.09006690 |
105 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.08835972 |
106 | Malaria_Homo sapiens_hsa05144 | 0.07350532 |
107 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.06953142 |
108 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.06748128 |
109 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.04827372 |
110 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.03375761 |
111 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.03272662 |
112 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.01781861 |
113 | Prostate cancer_Homo sapiens_hsa05215 | 0.01515941 |
114 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.01186324 |
115 | Amoebiasis_Homo sapiens_hsa05146 | 0.00973586 |
116 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.00920087 |
117 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.00426774 |
118 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.0708979 |
119 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | -0.0693761 |
120 | Linoleic acid metabolism_Homo sapiens_hsa00591 | -0.0531756 |
121 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.0415789 |
122 | Prolactin signaling pathway_Homo sapiens_hsa04917 | -0.0380460 |
123 | Legionellosis_Homo sapiens_hsa05134 | -0.0316864 |
124 | Hepatitis C_Homo sapiens_hsa05160 | -0.0236159 |
125 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | -0.0218732 |