GSTM3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dorsal/ventral neural tube patterning (GO:0021904)6.05060524
2type B pancreatic cell development (GO:0003323)5.72567586
3righting reflex (GO:0060013)5.31389187
4negative regulation of hormone biosynthetic process (GO:0032353)4.92298716
5DNA strand renaturation (GO:0000733)4.55292276
6fatty acid homeostasis (GO:0055089)4.38801691
7negative regulation of gluconeogenesis (GO:0045721)4.29743533
8negative regulation of hormone metabolic process (GO:0032351)4.16927149
9epithelial cell fate commitment (GO:0072148)4.14799360
10DNA replication checkpoint (GO:0000076)4.14217804
11glandular epithelial cell development (GO:0002068)4.05739419
12proline biosynthetic process (GO:0006561)4.01645867
13negative regulation of acute inflammatory response (GO:0002674)3.95422396
14neuron fate specification (GO:0048665)3.90288485
15muscle organ morphogenesis (GO:0048644)3.88994940
16positive regulation of glycolytic process (GO:0045821)3.88353841
17histone H2A acetylation (GO:0043968)3.87695538
18purine nucleobase biosynthetic process (GO:0009113)3.87457255
19endocrine pancreas development (GO:0031018)3.86119643
20ribosome assembly (GO:0042255)3.82652441
21translesion synthesis (GO:0019985)3.73557524
22nucleobase biosynthetic process (GO:0046112)3.69929606
23astrocyte differentiation (GO:0048708)3.62947244
24negative regulation of protein oligomerization (GO:0032460)3.41696447
25postreplication repair (GO:0006301)3.41135806
26negative regulation of glycogen metabolic process (GO:0070874)3.32534144
27positive regulation of insulin receptor signaling pathway (GO:0046628)3.27242961
28positive regulation of respiratory burst (GO:0060267)3.26268704
29positive regulation of macroautophagy (GO:0016239)3.25244681
30neuron fate determination (GO:0048664)3.23748195
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21604670
32chemosensory behavior (GO:0007635)3.18659323
33positive regulation of protein autophosphorylation (GO:0031954)3.15185829
34phosphorelay signal transduction system (GO:0000160)3.11874605
35valine metabolic process (GO:0006573)3.07638425
36nuclear pore organization (GO:0006999)3.07628616
37negative regulation of mRNA processing (GO:0050686)3.06530085
38kidney morphogenesis (GO:0060993)3.05830737
39peripheral nervous system neuron development (GO:0048935)3.03561468
40aggressive behavior (GO:0002118)3.03478823
41mitotic sister chromatid cohesion (GO:0007064)3.02766788
42DNA strand elongation involved in DNA replication (GO:0006271)3.00616735
43maturation of 5.8S rRNA (GO:0000460)2.99068305
44adrenergic receptor signaling pathway (GO:0071875)2.97406502
45cranial nerve development (GO:0021545)2.95683008
46proximal/distal pattern formation (GO:0009954)2.94886044
47dendritic spine morphogenesis (GO:0060997)2.90844707
48tRNA aminoacylation for protein translation (GO:0006418)2.90650804
49rRNA methylation (GO:0031167)2.84942746
50positive regulation of growth hormone secretion (GO:0060124)2.81701644
51DNA strand elongation (GO:0022616)2.81401307
52folic acid-containing compound biosynthetic process (GO:0009396)2.80917667
53positive regulation of glycogen biosynthetic process (GO:0045725)2.80615117
54telomere maintenance via semi-conservative replication (GO:0032201)2.75130935
55amino acid activation (GO:0043038)2.74716913
56tRNA aminoacylation (GO:0043039)2.74716913
57mitotic sister chromatid segregation (GO:0000070)2.72841708
58DNA replication initiation (GO:0006270)2.72326982
59negative regulation of mRNA metabolic process (GO:1903312)2.70299431
60positive regulation of response to nutrient levels (GO:0032109)2.67080946
61positive regulation of response to extracellular stimulus (GO:0032106)2.67080946
62ER overload response (GO:0006983)2.66942660
63positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.66604126
64nucleotide-excision repair, DNA gap filling (GO:0006297)2.66283117
65regulation of growth hormone secretion (GO:0060123)2.65435291
66viral mRNA export from host cell nucleus (GO:0046784)2.63686130
67glutamine metabolic process (GO:0006541)2.62612021
68regulation of DNA endoreduplication (GO:0032875)2.61237339
69proline metabolic process (GO:0006560)2.59896560
70positive regulation of cellular response to insulin stimulus (GO:1900078)2.59762445
71DNA replication-dependent nucleosome organization (GO:0034723)2.59623176
72DNA replication-dependent nucleosome assembly (GO:0006335)2.59623176
73biotin metabolic process (GO:0006768)2.57446703
74paraxial mesoderm development (GO:0048339)2.55394347
75positive regulation of oligodendrocyte differentiation (GO:0048714)2.54813820
76lactate metabolic process (GO:0006089)2.53339255
77regulation of hexokinase activity (GO:1903299)2.52980205
78regulation of glucokinase activity (GO:0033131)2.52980205
79intra-S DNA damage checkpoint (GO:0031573)2.50369932
80cellular ketone body metabolic process (GO:0046950)2.49965804
81sister chromatid segregation (GO:0000819)2.48970140
82positive regulation of nitric-oxide synthase activity (GO:0051000)2.45419736
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.44917354
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.44917354
85positive regulation of mitotic sister chromatid separation (GO:1901970)2.44917354
86rRNA modification (GO:0000154)2.44800903
87formation of translation preinitiation complex (GO:0001731)2.44762024
88nerve development (GO:0021675)2.44683603
89positive regulation of glycogen metabolic process (GO:0070875)2.44139042
90pteridine-containing compound biosynthetic process (GO:0042559)2.43253075
91alternative mRNA splicing, via spliceosome (GO:0000380)2.41472554
92regulation of type B pancreatic cell apoptotic process (GO:2000674)2.40766646
93regulation of steroid hormone biosynthetic process (GO:0090030)2.40126335
94tetrahydrofolate metabolic process (GO:0046653)2.39181549
95double-strand break repair via homologous recombination (GO:0000724)2.39057301
96ketone body metabolic process (GO:1902224)2.37732027
97chromatin remodeling at centromere (GO:0031055)2.37399243
98DNA biosynthetic process (GO:0071897)2.36614014
99regulation of glucocorticoid metabolic process (GO:0031943)2.36328329
100reflex (GO:0060004)2.35432498

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.16320033
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.61910480
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.38990895
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.04706505
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77033768
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.70943429
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62581977
8POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.40205101
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.29914563
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.28750157
11PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17758344
12YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16535781
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11417100
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.10477320
15FUS_26573619_Chip-Seq_HEK293_Human2.03365867
16TTF2_22483619_ChIP-Seq_HELA_Human2.02302933
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99745988
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96823224
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.96084326
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.88193493
21DCP1A_22483619_ChIP-Seq_HELA_Human1.84405791
22EZH2_22144423_ChIP-Seq_EOC_Human1.79303856
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78182807
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.70519110
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70486194
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.69641471
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68813927
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67167017
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.66034194
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63489014
31XRN2_22483619_ChIP-Seq_HELA_Human1.61100492
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61050611
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.53737913
34KDM5A_27292631_Chip-Seq_BREAST_Human1.52955184
35TFEB_21752829_ChIP-Seq_HELA_Human1.51738953
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51408728
37MYC_18940864_ChIP-ChIP_HL60_Human1.51001033
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50051062
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48167824
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45630571
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45513393
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45295661
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41428991
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41407606
45VDR_23849224_ChIP-Seq_CD4+_Human1.39218665
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38965574
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38761770
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36790963
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36612902
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36417143
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35808890
52FOXP3_21729870_ChIP-Seq_TREG_Human1.35207542
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.34924548
54CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32837152
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.29818268
56GABP_19822575_ChIP-Seq_HepG2_Human1.27989207
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27918214
58ZNF274_21170338_ChIP-Seq_K562_Hela1.27405910
59RNF2_27304074_Chip-Seq_NSC_Mouse1.27337890
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.27268396
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27198803
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27146766
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26045703
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21636703
65EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21479697
66EWS_26573619_Chip-Seq_HEK293_Human1.21464130
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18418811
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17621874
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14166112
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13789020
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.12693231
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05638661
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.02292706
74NFYB_21822215_ChIP-Seq_K562_Human0.99820337
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99305468
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99215311
77CIITA_25753668_ChIP-Seq_RAJI_Human0.98573044
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.98447622
79ELK1_19687146_ChIP-ChIP_HELA_Human0.97690210
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96701688
81REST_19997604_ChIP-ChIP_NEURONS_Mouse0.96268398
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95647919
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94999055
84SOX9_26525672_Chip-Seq_HEART_Mouse0.92378458
85FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91167301
86REST_21632747_ChIP-Seq_MESCs_Mouse0.90393088
87PHF8_20622853_ChIP-Seq_HELA_Human0.90165441
88AR_21909140_ChIP-Seq_LNCAP_Human0.83821825
89RARB_27405468_Chip-Seq_BRAIN_Mouse0.82969114
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.82770932
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81919506
92CHD1_26751641_Chip-Seq_LNCaP_Human0.81403481
93YY1_21170310_ChIP-Seq_MESCs_Mouse0.80786259
94JARID2_20064375_ChIP-Seq_MESCs_Mouse0.80670278
95POU3F2_20337985_ChIP-ChIP_501MEL_Human0.80046087
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79381572
97POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79097466
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76461353
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76254587
100TP53_20018659_ChIP-ChIP_R1E_Mouse0.75514793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology6.14186749
2MP0005379_endocrine/exocrine_gland_phen4.06047709
3MP0009780_abnormal_chondrocyte_physiolo3.87208290
4MP0002102_abnormal_ear_morphology3.80520517
5MP0003123_paternal_imprinting3.66987914
6MP0010234_abnormal_vibrissa_follicle2.86079471
7MP0008057_abnormal_DNA_replication2.63193593
8MP0002234_abnormal_pharynx_morphology2.36125902
9MP0003111_abnormal_nucleus_morphology2.32440873
10MP0010094_abnormal_chromosome_stability2.20865223
11MP0003195_calcinosis2.20367609
12MP0001346_abnormal_lacrimal_gland2.13545609
13MP0005377_hearing/vestibular/ear_phenot1.97646632
14MP0003878_abnormal_ear_physiology1.97646632
15MP0001944_abnormal_pancreas_morphology1.88642730
16MP0001486_abnormal_startle_reflex1.82749294
17MP0002876_abnormal_thyroid_physiology1.79626367
18MP0003787_abnormal_imprinting1.78867780
19MP0008058_abnormal_DNA_repair1.77314241
20MP0009697_abnormal_copulation1.77124194
21MP0010352_gastrointestinal_tract_polyps1.71024238
22MP0003656_abnormal_erythrocyte_physiolo1.58866650
23MP0010307_abnormal_tumor_latency1.55459852
24MP0004957_abnormal_blastocyst_morpholog1.52881986
25MP0005187_abnormal_penis_morphology1.48476988
26MP0002277_abnormal_respiratory_mucosa1.47544818
27MP0002693_abnormal_pancreas_physiology1.45848865
28MP0003693_abnormal_embryo_hatching1.43320964
29MP0002938_white_spotting1.35785267
30MP0008007_abnormal_cellular_replicative1.33578128
31MP0002233_abnormal_nose_morphology1.32424048
32MP0002909_abnormal_adrenal_gland1.31548657
33MP0003283_abnormal_digestive_organ1.30760364
34MP0008877_abnormal_DNA_methylation1.27984206
35MP0005499_abnormal_olfactory_system1.27403875
36MP0005394_taste/olfaction_phenotype1.27403875
37MP0004147_increased_porphyrin_level1.24028200
38MP0009672_abnormal_birth_weight1.22005246
39MP0000428_abnormal_craniofacial_morphol1.20983519
40MP0000372_irregular_coat_pigmentation1.20298153
41MP0005220_abnormal_exocrine_pancreas1.16955302
42MP0003077_abnormal_cell_cycle1.16456121
43MP0009703_decreased_birth_body1.13047916
44MP0004142_abnormal_muscle_tone1.10821912
45MP0000678_abnormal_parathyroid_gland1.10594151
46MP0005171_absent_coat_pigmentation1.09380128
47MP0001727_abnormal_embryo_implantation1.01543578
48MP0010678_abnormal_skin_adnexa0.99395868
49MP0000955_abnormal_spinal_cord0.97981404
50MP0003136_yellow_coat_color0.96957549
51MP0003718_maternal_effect0.94333245
52MP0003119_abnormal_digestive_system0.93120905
53MP0003890_abnormal_embryonic-extraembry0.92223126
54MP0005646_abnormal_pituitary_gland0.91543719
55MP0006054_spinal_hemorrhage0.90752579
56MP0001697_abnormal_embryo_size0.89310819
57MP0003172_abnormal_lysosome_physiology0.87022445
58MP0009278_abnormal_bone_marrow0.86560150
59MP0009046_muscle_twitch0.85446298
60MP0000516_abnormal_urinary_system0.85203913
61MP0005367_renal/urinary_system_phenotyp0.85203913
62MP0003942_abnormal_urinary_system0.84219213
63MP0004197_abnormal_fetal_growth/weight/0.84051942
64MP0000350_abnormal_cell_proliferation0.82437782
65MP0000631_abnormal_neuroendocrine_gland0.82084284
66MP0003937_abnormal_limbs/digits/tail_de0.81195075
67MP0002078_abnormal_glucose_homeostasis0.80195987
68MP0001348_abnormal_lacrimal_gland0.79253122
69MP0001440_abnormal_grooming_behavior0.77481879
70MP0005380_embryogenesis_phenotype0.77401958
71MP0001672_abnormal_embryogenesis/_devel0.77401958
72MP0002063_abnormal_learning/memory/cond0.75770720
73MP0003121_genomic_imprinting0.75114724
74MP0005551_abnormal_eye_electrophysiolog0.75052874
75MP0002822_catalepsy0.74384125
76MP0002090_abnormal_vision0.73949586
77MP0001730_embryonic_growth_arrest0.72768323
78MP0003984_embryonic_growth_retardation0.72212602
79MP0002210_abnormal_sex_determination0.71698020
80MP0002085_abnormal_embryonic_tissue0.71658992
81MP0001984_abnormal_olfaction0.71496563
82MP0002084_abnormal_developmental_patter0.70374601
83MP0003635_abnormal_synaptic_transmissio0.69143958
84MP0008932_abnormal_embryonic_tissue0.68856965
85MP0003698_abnormal_male_reproductive0.68259396
86MP0002088_abnormal_embryonic_growth/wei0.67951902
87MP0002572_abnormal_emotion/affect_behav0.67837167
88MP0000003_abnormal_adipose_tissue0.67826082
89MP0004859_abnormal_synaptic_plasticity0.67622811
90MP0004742_abnormal_vestibular_system0.67149858
91MP0002557_abnormal_social/conspecific_i0.65522081
92MP0002229_neurodegeneration0.65225912
93MP0001929_abnormal_gametogenesis0.65221181
94MP0005452_abnormal_adipose_tissue0.65111067
95MP0003861_abnormal_nervous_system0.65063867
96MP0000427_abnormal_hair_cycle0.64838306
97MP0002653_abnormal_ependyma_morphology0.63920741
98MP0002064_seizures0.63904299
99MP0009745_abnormal_behavioral_response0.63800225
100MP0001293_anophthalmia0.62793064

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)6.53035721
2Hyperinsulinemic hypoglycemia (HP:0000825)6.27271032
3Abnormality of the pancreatic islet cells (HP:0006476)5.49571334
4Abnormality of endocrine pancreas physiology (HP:0012093)5.49571334
5Ketoacidosis (HP:0001993)5.21075056
6Hypoglycemic coma (HP:0001325)5.00723816
7Neoplasm of the adrenal cortex (HP:0100641)4.84619374
8Broad distal phalanx of finger (HP:0009836)4.48161531
9Symptomatic seizures (HP:0011145)4.43757546
10Hypothermia (HP:0002045)3.91927072
11Septate vagina (HP:0001153)3.72729341
12Hyperglycemia (HP:0003074)3.66814138
13Urethral obstruction (HP:0000796)3.63980945
14Prominent metopic ridge (HP:0005487)3.57040393
15Pancreatic islet-cell hyperplasia (HP:0004510)3.55939029
16Metaphyseal dysplasia (HP:0100255)3.45349551
17Gastrointestinal atresia (HP:0002589)3.35927865
18Large for gestational age (HP:0001520)3.35920979
19Tongue fasciculations (HP:0001308)3.34737226
20Stridor (HP:0010307)3.21960639
21Late onset (HP:0003584)3.07849754
22Hepatoblastoma (HP:0002884)3.05836956
23Abnormality of the metopic suture (HP:0005556)2.98036945
24Hypomagnesemia (HP:0002917)2.94399539
25Rectal fistula (HP:0100590)2.89185549
26Rectovaginal fistula (HP:0000143)2.89185549
27Neoplasm of the adrenal gland (HP:0100631)2.85000445
28Ketosis (HP:0001946)2.84370611
29Neonatal hypoglycemia (HP:0001998)2.73119538
30Muscle fibrillation (HP:0010546)2.71793443
31EEG with generalized epileptiform discharges (HP:0011198)2.67103027
32Hypsarrhythmia (HP:0002521)2.66285294
33Epileptiform EEG discharges (HP:0011182)2.64723384
34Hyperthyroidism (HP:0000836)2.64613416
35Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.62348380
36Intestinal fistula (HP:0100819)2.60465456
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.58799564
38Hypokinesia (HP:0002375)2.58319162
39Hemiparesis (HP:0001269)2.56415059
40Bifid scrotum (HP:0000048)2.51207442
41Germ cell neoplasia (HP:0100728)2.49232975
42Rhabdomyosarcoma (HP:0002859)2.47777428
43Febrile seizures (HP:0002373)2.41926263
44Anal stenosis (HP:0002025)2.41289635
45Vaginal fistula (HP:0004320)2.40403773
46Abnormality of lateral ventricle (HP:0030047)2.39638616
47Abnormal sex determination (HP:0012244)2.39545164
48Sex reversal (HP:0012245)2.39545164
49Esophageal atresia (HP:0002032)2.35970716
50Embryonal neoplasm (HP:0002898)2.32508427
51Enlarged penis (HP:0000040)2.31463974
52Downturned corners of mouth (HP:0002714)2.25540057
53Cutaneous melanoma (HP:0012056)2.24295924
54Neoplasm of striated muscle (HP:0009728)2.21240110
55Intestinal atresia (HP:0011100)2.17129856
56Abnormality of magnesium homeostasis (HP:0004921)2.13114244
57Diastasis recti (HP:0001540)2.11116809
58Nephroblastoma (Wilms tumor) (HP:0002667)2.07837816
59Lower limb hyperreflexia (HP:0002395)2.07172975
60Increased circulating renin level (HP:0000848)1.99911999
61Anal atresia (HP:0002023)1.99398954
62Unilateral renal agenesis (HP:0000122)1.96951746
63Enlarged kidneys (HP:0000105)1.94958573
64Tachypnea (HP:0002789)1.94645741
65Embryonal renal neoplasm (HP:0011794)1.92775946
66Asymmetric growth (HP:0100555)1.90136408
67Calcaneovalgus deformity (HP:0001848)1.89284596
68Muscular hypotonia of the trunk (HP:0008936)1.86512360
69Type I diabetes mellitus (HP:0100651)1.85448123
70Preauricular pit (HP:0004467)1.84886482
71Periauricular skin pits (HP:0100277)1.84886482
72Conjunctival hamartoma (HP:0100780)1.80578922
73Abnormality of the pubic bones (HP:0003172)1.78499873
74Atresia of the external auditory canal (HP:0000413)1.77791949
75Limb hypertonia (HP:0002509)1.77731780
76Truncus arteriosus (HP:0001660)1.75912693
77Hamartoma of the eye (HP:0010568)1.75531591
78Lower limb asymmetry (HP:0100559)1.74540621
79Hepatic necrosis (HP:0002605)1.72839495
80Median cleft lip (HP:0000161)1.72202227
81Short middle phalanx of the 5th finger (HP:0004220)1.71185494
82Occipital encephalocele (HP:0002085)1.70812096
83Abnormality of the aortic arch (HP:0012303)1.70215612
84Macroorchidism (HP:0000053)1.69469170
85Abnormality of homocysteine metabolism (HP:0010919)1.66662846
86Homocystinuria (HP:0002156)1.66662846
87Pancreatic fibrosis (HP:0100732)1.65411153
88Adenoma sebaceum (HP:0009720)1.64358453
89Angiofibromas (HP:0010615)1.64358453
90Status epilepticus (HP:0002133)1.63788940
91Congenital malformation of the right heart (HP:0011723)1.60470543
92Double outlet right ventricle (HP:0001719)1.60470543
93Deformed tarsal bones (HP:0008119)1.59881645
94Glossoptosis (HP:0000162)1.59801671
95Overlapping toe (HP:0001845)1.59133094
96Microglossia (HP:0000171)1.58023285
97Generalized tonic-clonic seizures (HP:0002069)1.57431265
98Progressive macrocephaly (HP:0004481)1.55069035
99Short humerus (HP:0005792)1.53919187
100Colon cancer (HP:0003003)1.53881829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.17434966
2PNCK3.85645075
3TRIM283.74389897
4FGFR23.30606221
5NME13.14794179
6NTRK33.08704546
7BCR3.01563818
8BUB13.00668871
9WEE13.00059080
10PHKG22.49081048
11PHKG12.49081048
12NLK2.24719663
13TAOK12.13293224
14TSSK62.12722417
15SMG12.01324076
16TNIK1.89795917
17MKNK21.74691961
18MKNK11.65501167
19INSRR1.64352784
20PASK1.54869448
21MAP3K21.49417799
22TTK1.48993245
23EIF2AK31.46987997
24PLK31.46663787
25MAP3K101.44423822
26EIF2AK11.44412965
27MAP3K71.42377248
28CDC71.40118693
29EIF2AK21.25840071
30ZAK1.22242629
31VRK21.21226565
32STK31.19417293
33CAMK1G1.19240543
34TAF11.10341548
35FGFR31.07303369
36YES11.05872945
37DYRK1A1.02376470
38BRD40.96904687
39CSNK1G10.95878338
40FGFR10.95176046
41EEF2K0.93857662
42ATR0.93273656
43CHEK10.91984313
44STK110.91458944
45CDK30.86095792
46DAPK20.85967410
47NEK10.82970512
48TRPM70.81017632
49MET0.80220583
50CSNK1G30.80051667
51CSNK1A1L0.76654826
52LATS10.75239347
53DAPK10.74576854
54PLK10.73650527
55ALK0.70529696
56ATM0.69996269
57MAPKAPK50.68848783
58MAP3K10.67268008
59PRKAA10.64496801
60WNK40.63306086
61FER0.63262506
62CHEK20.58999170
63EPHA30.57466567
64PRKAA20.57433145
65PRKCG0.56394326
66CDK20.52676444
67CDK10.52412623
68AURKB0.51017546
69STK40.47472317
70CDK180.46549991
71CDK150.46476266
72MAP4K20.46273493
73MELK0.46169509
74PRKDC0.45010516
75STK38L0.44975621
76CSNK1A10.43928645
77STK390.43465725
78SGK20.43417171
79MAP3K90.43211812
80TEC0.42909302
81CDK11A0.42325513
82HIPK20.42236067
83NUAK10.41454660
84CSNK1G20.40148958
85SRPK10.39700398
86KSR20.38077746
87UHMK10.36618551
88IRAK10.36007997
89CDK70.34887394
90MAPK140.33732434
91SGK30.33368370
92AURKA0.32498402
93KSR10.32122643
94CDK140.31298147
95CSNK2A20.30902222
96RPS6KB10.30237113
97CSNK1E0.29446818
98GSK3B0.29196074
99PLK20.28620064
100SGK2230.28359672

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.55629796
2Butanoate metabolism_Homo sapiens_hsa006502.75996226
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.74138549
4Homologous recombination_Homo sapiens_hsa034402.45934962
5Non-homologous end-joining_Homo sapiens_hsa034502.44379288
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19568401
7DNA replication_Homo sapiens_hsa030302.18806824
8Vitamin B6 metabolism_Homo sapiens_hsa007502.18541277
9Protein export_Homo sapiens_hsa030602.05922718
10Mismatch repair_Homo sapiens_hsa034301.96724555
11Fatty acid elongation_Homo sapiens_hsa000621.83712256
12Insulin secretion_Homo sapiens_hsa049111.83352643
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79524440
14Fatty acid metabolism_Homo sapiens_hsa012121.68984077
15Type II diabetes mellitus_Homo sapiens_hsa049301.63584147
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62249031
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62198901
18One carbon pool by folate_Homo sapiens_hsa006701.58279709
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56957397
20Spliceosome_Homo sapiens_hsa030401.50900196
21Steroid biosynthesis_Homo sapiens_hsa001001.47449264
22Cell cycle_Homo sapiens_hsa041101.45637555
23RNA transport_Homo sapiens_hsa030131.36334495
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34856471
25mTOR signaling pathway_Homo sapiens_hsa041501.33012525
26Lysine degradation_Homo sapiens_hsa003101.31280474
27Regulation of autophagy_Homo sapiens_hsa041401.30400090
28Base excision repair_Homo sapiens_hsa034101.29738161
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26028868
30Nucleotide excision repair_Homo sapiens_hsa034201.25786933
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24743054
32Synaptic vesicle cycle_Homo sapiens_hsa047211.21986642
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16707608
34Propanoate metabolism_Homo sapiens_hsa006401.15340997
35Oocyte meiosis_Homo sapiens_hsa041141.09742227
36Fanconi anemia pathway_Homo sapiens_hsa034601.06565679
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.06431301
38Glucagon signaling pathway_Homo sapiens_hsa049221.04485806
39Collecting duct acid secretion_Homo sapiens_hsa049661.00141757
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99748648
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96558531
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93878814
43N-Glycan biosynthesis_Homo sapiens_hsa005100.90530197
44AMPK signaling pathway_Homo sapiens_hsa041520.87981835
45Selenocompound metabolism_Homo sapiens_hsa004500.86895394
46Hedgehog signaling pathway_Homo sapiens_hsa043400.86589373
47Basal transcription factors_Homo sapiens_hsa030220.85348031
48RNA degradation_Homo sapiens_hsa030180.84456543
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80773567
50mRNA surveillance pathway_Homo sapiens_hsa030150.78118146
51Nicotine addiction_Homo sapiens_hsa050330.77992965
52Tryptophan metabolism_Homo sapiens_hsa003800.76048999
53Folate biosynthesis_Homo sapiens_hsa007900.73233416
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72546294
55GABAergic synapse_Homo sapiens_hsa047270.72177394
56Renin secretion_Homo sapiens_hsa049240.71585457
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70008772
58Arginine biosynthesis_Homo sapiens_hsa002200.69995495
59Purine metabolism_Homo sapiens_hsa002300.69903834
60RNA polymerase_Homo sapiens_hsa030200.67935443
61Fatty acid biosynthesis_Homo sapiens_hsa000610.66063639
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65968221
63beta-Alanine metabolism_Homo sapiens_hsa004100.65539552
64Salivary secretion_Homo sapiens_hsa049700.65184940
65p53 signaling pathway_Homo sapiens_hsa041150.64293770
66Wnt signaling pathway_Homo sapiens_hsa043100.61848785
67Pyruvate metabolism_Homo sapiens_hsa006200.59595668
68Vibrio cholerae infection_Homo sapiens_hsa051100.58186838
69Thyroid hormone synthesis_Homo sapiens_hsa049180.54329518
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53900468
71Glutamatergic synapse_Homo sapiens_hsa047240.52795056
72Prostate cancer_Homo sapiens_hsa052150.52591251
73Thyroid cancer_Homo sapiens_hsa052160.50113211
74Circadian rhythm_Homo sapiens_hsa047100.49920469
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47392173
76Type I diabetes mellitus_Homo sapiens_hsa049400.44521546
77Ether lipid metabolism_Homo sapiens_hsa005650.43599306
78Fatty acid degradation_Homo sapiens_hsa000710.43344887
79African trypanosomiasis_Homo sapiens_hsa051430.43234671
80Arginine and proline metabolism_Homo sapiens_hsa003300.43063849
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43035670
82Basal cell carcinoma_Homo sapiens_hsa052170.42881839
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42785240
84Insulin resistance_Homo sapiens_hsa049310.42582408
85Morphine addiction_Homo sapiens_hsa050320.41346817
86Melanogenesis_Homo sapiens_hsa049160.39993892
87Pyrimidine metabolism_Homo sapiens_hsa002400.39867173
88Insulin signaling pathway_Homo sapiens_hsa049100.39696985
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39533656
90Mineral absorption_Homo sapiens_hsa049780.39174438
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38035801
92Circadian entrainment_Homo sapiens_hsa047130.37164414
93Sphingolipid metabolism_Homo sapiens_hsa006000.37051274
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36757927
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36616256
96Long-term depression_Homo sapiens_hsa047300.35928001
97Biosynthesis of amino acids_Homo sapiens_hsa012300.34965283
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.33252965
99Amphetamine addiction_Homo sapiens_hsa050310.33117557
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33059397

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