GSTM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.70161121
2axon ensheathment in central nervous system (GO:0032291)7.70161121
3acrosome reaction (GO:0007340)7.37203385
4fusion of sperm to egg plasma membrane (GO:0007342)7.28343001
5sperm motility (GO:0030317)7.26393832
6multicellular organism reproduction (GO:0032504)5.96481651
7acrosome assembly (GO:0001675)5.91003489
8epithelial cilium movement (GO:0003351)5.88814861
9cilium or flagellum-dependent cell motility (GO:0001539)5.88364400
10cell wall macromolecule metabolic process (GO:0044036)5.86286633
11cell wall macromolecule catabolic process (GO:0016998)5.86286633
12axonemal dynein complex assembly (GO:0070286)5.71589638
13plasma membrane fusion (GO:0045026)5.60065500
14sperm-egg recognition (GO:0035036)5.47624321
15synaptic vesicle docking involved in exocytosis (GO:0016081)5.25607257
16regulation of cilium movement (GO:0003352)5.20768939
17cilium movement (GO:0003341)5.11967886
18fatty acid elongation (GO:0030497)4.97938617
19spermatid development (GO:0007286)4.94765648
20reproduction (GO:0000003)4.93895353
21negative regulation of inclusion body assembly (GO:0090084)4.92441643
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.88981721
23synaptic vesicle maturation (GO:0016188)4.87282444
24motile cilium assembly (GO:0044458)4.85031311
25binding of sperm to zona pellucida (GO:0007339)4.83833325
26sperm capacitation (GO:0048240)4.77518935
27cell-cell recognition (GO:0009988)4.76403360
28relaxation of smooth muscle (GO:0044557)4.70768617
29neuronal action potential propagation (GO:0019227)4.58276552
30piRNA metabolic process (GO:0034587)4.48294064
31regulation of inclusion body assembly (GO:0090083)4.39550564
32single fertilization (GO:0007338)4.32324326
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.30733617
34glutamate secretion (GO:0014047)4.09237758
35calcium ion-dependent exocytosis (GO:0017156)4.02705008
36regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.01118319
37regulation of synaptic vesicle exocytosis (GO:2000300)3.97882686
38synaptic vesicle exocytosis (GO:0016079)3.97437214
39male meiosis (GO:0007140)3.96734528
40long-chain fatty acid biosynthetic process (GO:0042759)3.96631236
41L-amino acid import (GO:0043092)3.96369003
42myelination (GO:0042552)3.86129855
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.85798634
44ensheathment of neurons (GO:0007272)3.79369845
45axon ensheathment (GO:0008366)3.79369845
46regulation of female receptivity (GO:0045924)3.76876607
47regulation of voltage-gated calcium channel activity (GO:1901385)3.73814801
48response to methylmercury (GO:0051597)3.65804421
49positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.62714770
50cerebellar granule cell differentiation (GO:0021707)3.62164327
51synaptonemal complex organization (GO:0070193)3.61414994
52regulation of platelet aggregation (GO:0090330)3.61182000
53negative regulation of heart rate (GO:0010459)3.60740762
54regulation of synaptic vesicle transport (GO:1902803)3.60588290
55fertilization (GO:0009566)3.58927609
56negative regulation of calcium ion transmembrane transport (GO:1903170)3.58862390
57negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.58862390
58cellular potassium ion homeostasis (GO:0030007)3.54467997
59regulation of long-term neuronal synaptic plasticity (GO:0048169)3.52807405
60regulation of microtubule-based movement (GO:0060632)3.50886971
61negative regulation of homotypic cell-cell adhesion (GO:0034111)3.47426696
62regulation of neuronal synaptic plasticity (GO:0048168)3.44445319
63neurotransmitter uptake (GO:0001504)3.42594021
64ventricular system development (GO:0021591)3.42486484
65negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.41471473
66postsynaptic membrane organization (GO:0001941)3.40663860
67spermatogenesis (GO:0007283)3.38287504
68male gamete generation (GO:0048232)3.36720037
69sodium ion export (GO:0071436)3.34169777
70relaxation of muscle (GO:0090075)3.33509339
71protein localization to cilium (GO:0061512)3.30682450
72synaptonemal complex assembly (GO:0007130)3.29157933
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.27161949
74negative regulation of response to food (GO:0032096)3.25964443
75negative regulation of appetite (GO:0032099)3.25964443
76microtubule severing (GO:0051013)3.25487499
77negative regulation of protein localization to cell surface (GO:2000009)3.24967597
78regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.21556805
79cGMP-mediated signaling (GO:0019934)3.19557830
80negative regulation of cation channel activity (GO:2001258)3.18743024
81potassium ion import (GO:0010107)3.17678737
82response to gravity (GO:0009629)3.16865814
83regulation of synapse structural plasticity (GO:0051823)3.16706981
84myelin maintenance (GO:0043217)3.16564796
85neurotransmitter secretion (GO:0007269)3.16365903
86organic cation transport (GO:0015695)3.16006473
87vocalization behavior (GO:0071625)3.15772402
88gamete generation (GO:0007276)3.15753062
89regulation of sensory perception (GO:0051931)3.14489343
90regulation of sensory perception of pain (GO:0051930)3.14489343
91negative regulation of neurotransmitter transport (GO:0051589)3.13358071
92activation of protein kinase A activity (GO:0034199)3.11945643
93cell recognition (GO:0008037)3.10929398
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09601319
95gamma-aminobutyric acid signaling pathway (GO:0007214)3.09061385
96regulation of glutamate receptor signaling pathway (GO:1900449)3.08068913
97regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.07685742
98amino acid import (GO:0043090)3.05218836
99gamma-aminobutyric acid transport (GO:0015812)3.04183002
100C4-dicarboxylate transport (GO:0015740)3.03442893
101DNA methylation involved in gamete generation (GO:0043046)3.02038579
102locomotory exploration behavior (GO:0035641)3.01906915
103neurotransmitter-gated ion channel clustering (GO:0072578)3.01154416
104female mating behavior (GO:0060180)3.00602951
105microtubule depolymerization (GO:0007019)3.00176027
106positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.00033922
107negative regulation of heart contraction (GO:0045822)2.99216640
108adenosine receptor signaling pathway (GO:0001973)2.98014152
109spermatid nucleus differentiation (GO:0007289)2.97538302
110positive regulation of dendritic spine development (GO:0060999)2.96358441
111sleep (GO:0030431)2.94264134
112negative regulation of muscle contraction (GO:0045932)2.92247244
113neuron cell-cell adhesion (GO:0007158)2.88194299
114cholesterol biosynthetic process (GO:0006695)2.87654961
115oligodendrocyte differentiation (GO:0048709)2.85410127
116membrane depolarization during action potential (GO:0086010)2.85153419
117regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.85106369
118microtubule polymerization or depolymerization (GO:0031109)2.85087158
119neuronal ion channel clustering (GO:0045161)2.83753796
120eye photoreceptor cell differentiation (GO:0001754)2.81867115
121photoreceptor cell differentiation (GO:0046530)2.81867115
122protein polyglutamylation (GO:0018095)2.81005507
123dendritic spine morphogenesis (GO:0060997)2.80947724
124cilium morphogenesis (GO:0060271)2.79591046
125ionotropic glutamate receptor signaling pathway (GO:0035235)2.79232570
126presynaptic membrane organization (GO:0097090)2.78731838
127regulation of response to food (GO:0032095)2.77901845
128cell communication by electrical coupling (GO:0010644)2.77134342
129auditory behavior (GO:0031223)2.76802138
130regulation of collateral sprouting (GO:0048670)2.76707825
131regulation of integrin-mediated signaling pathway (GO:2001044)2.76669245
132regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.75430825
133negative regulation of platelet activation (GO:0010544)2.74150406
134substantia nigra development (GO:0021762)2.72895620
135regulation of neurotransmitter secretion (GO:0046928)2.72811422
136germ cell development (GO:0007281)2.71687238
137transmission of nerve impulse (GO:0019226)2.71479593
138regulation of platelet activation (GO:0010543)2.70693213
139long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.69349892
140synaptic transmission, glutamatergic (GO:0035249)2.68788654
141regulation of excitatory postsynaptic membrane potential (GO:0060079)2.68473485
142long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.66903513
143mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.66681836
144positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.65805748
145cellular process involved in reproduction in multicellular organism (GO:0022412)2.65333909
146presynaptic membrane assembly (GO:0097105)2.64095755
147exploration behavior (GO:0035640)2.63607459
148peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.63308612
149sterol biosynthetic process (GO:0016126)2.63008570
150myelination in peripheral nervous system (GO:0022011)2.62566930
151peripheral nervous system axon ensheathment (GO:0032292)2.62566930
152positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.62118674
153regulation of neurotransmitter levels (GO:0001505)2.62086136
154intraciliary transport (GO:0042073)2.61930787
155vesicle docking involved in exocytosis (GO:0006904)2.61789407
156negative regulation of actin filament bundle assembly (GO:0032232)2.61153220
157ATP hydrolysis coupled proton transport (GO:0015991)2.61087887
158energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.61087887
159synaptic vesicle endocytosis (GO:0048488)2.60946107
160negative regulation of smooth muscle contraction (GO:0045986)2.60086804
161regulation of lipoprotein metabolic process (GO:0050746)2.59577816
162regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.59072349
163regulation of glutamate secretion (GO:0014048)2.58472653
164neurotransmitter transport (GO:0006836)2.57228987
165regulation of calcium ion transmembrane transporter activity (GO:1901019)2.56939604
166regulation of calcium ion transmembrane transport (GO:1903169)2.56939604
167male meiosis I (GO:0007141)2.55603312
168membrane depolarization (GO:0051899)2.54437281
169neuron-neuron synaptic transmission (GO:0007270)2.54280253
170cGMP metabolic process (GO:0046068)2.53629530
171astrocyte development (GO:0014002)2.53621983
172axoneme assembly (GO:0035082)2.51591430
173glutamate receptor signaling pathway (GO:0007215)2.51573630
174acidic amino acid transport (GO:0015800)2.50843863
175regulation of neurotransmitter transport (GO:0051588)2.50520070
176ATP synthesis coupled proton transport (GO:0015986)2.49772605
177energy coupled proton transport, down electrochemical gradient (GO:0015985)2.49772605
178regulation of dopamine metabolic process (GO:0042053)2.49283112
179negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49242632
180glycerophospholipid catabolic process (GO:0046475)2.48414819
181response to redox state (GO:0051775)2.47709126
182multicellular organismal reproductive process (GO:0048609)2.44982587
183glycerol ether metabolic process (GO:0006662)2.43854160
184establishment of mitochondrion localization (GO:0051654)2.43177171
185asymmetric protein localization (GO:0008105)2.42180398
186protein neddylation (GO:0045116)2.41197903
187cerebral cortex radially oriented cell migration (GO:0021799)2.40296816
188hydrogen ion transmembrane transport (GO:1902600)2.39628256
189GTP biosynthetic process (GO:0006183)2.39556449
190respiratory electron transport chain (GO:0022904)2.38408585
191polyol transport (GO:0015791)2.37682372
192electron transport chain (GO:0022900)2.37652528
193isoprenoid biosynthetic process (GO:0008299)2.36781429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.08946683
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.13442059
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.82847300
4GBX2_23144817_ChIP-Seq_PC3_Human2.53132200
5VDR_22108803_ChIP-Seq_LS180_Human2.38921050
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30601826
7SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.28269338
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26408457
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.15704546
10TAF15_26573619_Chip-Seq_HEK293_Human2.08520741
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08334882
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05218547
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93113612
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81653359
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78060409
16EZH2_27304074_Chip-Seq_ESCs_Mouse1.75896321
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74746802
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74627098
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74123409
20REST_21632747_ChIP-Seq_MESCs_Mouse1.73030161
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69205491
22MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68914996
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68073086
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67848822
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64033111
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63226399
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.63039964
28ZNF274_21170338_ChIP-Seq_K562_Hela1.59139725
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56574992
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56430829
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.54325620
32* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54087012
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53756666
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.52910815
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51949328
36* EED_16625203_ChIP-ChIP_MESCs_Mouse1.50676184
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48268598
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.48173497
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46682512
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46300006
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46288728
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44868700
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44868700
44FUS_26573619_Chip-Seq_HEK293_Human1.44744908
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44481181
46RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.43061392
47ER_23166858_ChIP-Seq_MCF-7_Human1.42465649
48IGF1R_20145208_ChIP-Seq_DFB_Human1.41199053
49SCL_19346495_ChIP-Seq_HPC-7_Human1.40122572
50RNF2_27304074_Chip-Seq_NSC_Mouse1.40114574
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39003491
52TAL1_26923725_Chip-Seq_HPCs_Mouse1.38635175
53P300_19829295_ChIP-Seq_ESCs_Human1.36692586
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36635029
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36323448
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35818117
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35567898
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35175140
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.34445448
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33198199
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32024899
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31501791
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.30387104
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.29865415
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28908095
66* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28383468
67SMAD4_21799915_ChIP-Seq_A2780_Human1.26383002
68GATA1_26923725_Chip-Seq_HPCs_Mouse1.25830991
69KDM2B_26808549_Chip-Seq_REH_Human1.25318991
70* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25021185
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23565818
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23111036
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22897286
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21577346
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20518244
76NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20382923
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17774094
78CMYC_18555785_Chip-Seq_ESCs_Mouse1.17474314
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15899113
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.14136780
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12559885
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11862831
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11862831
84* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11222230
85P53_22387025_ChIP-Seq_ESCs_Mouse1.11051052
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.10191849
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09470029
88DROSHA_22980978_ChIP-Seq_HELA_Human1.09390354
89AR_21572438_ChIP-Seq_LNCaP_Human1.08378705
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08237544
91CBP_20019798_ChIP-Seq_JUKART_Human1.08237544
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08217312
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07993777
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07520340
95P300_18555785_Chip-Seq_ESCs_Mouse1.07453554
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06443862
97BCAT_22108803_ChIP-Seq_LS180_Human1.05390755
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.04303593
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04090535
100HTT_18923047_ChIP-ChIP_STHdh_Human1.03347699
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03250014
102AR_25329375_ChIP-Seq_VCAP_Human1.02893836
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.02469492
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.02311491
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01565379
106SOX2_21211035_ChIP-Seq_LN229_Gbm1.01437008
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01113411
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.00859632
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00519374
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00519374
111TCF4_23295773_ChIP-Seq_U87_Human0.99683456
112FLI1_21867929_ChIP-Seq_TH2_Mouse0.99444282
113EP300_21415370_ChIP-Seq_HL-1_Mouse0.99353529
114KLF4_18555785_Chip-Seq_ESCs_Mouse0.99303551
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98644252
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98626373
117SOX2_18555785_Chip-Seq_ESCs_Mouse0.98260245
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98107919
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97361391
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96818171
121OCT4_18555785_Chip-Seq_ESCs_Mouse0.96043348
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.95440138
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95047090
124EZH2_27294783_Chip-Seq_NPCs_Mouse0.95035493
125STAT3_23295773_ChIP-Seq_U87_Human0.94831768
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.94021248
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91803507
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90555714
129VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89692719
130* ARNT_22903824_ChIP-Seq_MCF-7_Human0.88977658
131AR_19668381_ChIP-Seq_PC3_Human0.88647044
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88487199
133GATA1_19941826_ChIP-Seq_K562_Human0.88161633
134RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87198759
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86802787
136ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86718509
137CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84782868
138GATA1_19941827_ChIP-Seq_MEL_Mouse0.82474817
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80805201
140SMAD_19615063_ChIP-ChIP_OVARY_Human0.79220689
141WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78117452

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.74813085
2MP0003880_abnormal_central_pattern3.28392239
3MP0003698_abnormal_male_reproductive2.76950914
4MP0009780_abnormal_chondrocyte_physiolo2.72627890
5MP0005464_abnormal_platelet_physiology2.68848423
6MP0001529_abnormal_vocalization2.68254557
7MP0004270_analgesia2.61375203
8MP0000920_abnormal_myelination2.59099866
9MP0003329_amyloid_beta_deposits2.57232582
10MP0008004_abnormal_stomach_pH2.28185634
11MP0009046_muscle_twitch2.21239875
12MP0001486_abnormal_startle_reflex2.20328808
13MP0001929_abnormal_gametogenesis2.18337978
14MP0003879_abnormal_hair_cell2.17198337
15MP0001984_abnormal_olfaction2.11927234
16MP0001905_abnormal_dopamine_level2.11814173
17MP0004885_abnormal_endolymph2.10718212
18MP0002272_abnormal_nervous_system2.08077598
19MP0005423_abnormal_somatic_nervous2.05319923
20MP0004859_abnormal_synaptic_plasticity2.03912453
21MP0005167_abnormal_blood-brain_barrier2.00601249
22MP0002064_seizures1.98400655
23MP0003690_abnormal_glial_cell1.96071878
24MP0003635_abnormal_synaptic_transmissio1.95509710
25MP0010368_abnormal_lymphatic_system1.94175567
26MP0009745_abnormal_behavioral_response1.92013111
27MP0003136_yellow_coat_color1.87262884
28MP0003950_abnormal_plasma_membrane1.84513745
29MP0004742_abnormal_vestibular_system1.83903631
30MP0004130_abnormal_muscle_cell1.77366690
31MP0002572_abnormal_emotion/affect_behav1.71414635
32MP0002734_abnormal_mechanical_nocicepti1.70888465
33MP0001485_abnormal_pinna_reflex1.67725001
34MP0000778_abnormal_nervous_system1.64755302
35MP0002736_abnormal_nociception_after1.64302259
36MP0002063_abnormal_learning/memory/cond1.62516822
37MP0005503_abnormal_tendon_morphology1.61489634
38MP0001968_abnormal_touch/_nociception1.60890157
39MP0004142_abnormal_muscle_tone1.59924298
40MP0004043_abnormal_pH_regulation1.59561075
41MP0005275_abnormal_skin_tensile1.57603017
42MP0001440_abnormal_grooming_behavior1.56656101
43MP0003634_abnormal_glial_cell1.56328713
44MP0000230_abnormal_systemic_arterial1.55999108
45MP0005551_abnormal_eye_electrophysiolog1.54055543
46MP0005171_absent_coat_pigmentation1.53999151
47MP0010386_abnormal_urinary_bladder1.53963611
48MP0004084_abnormal_cardiac_muscle1.48827352
49MP0008877_abnormal_DNA_methylation1.46257322
50MP0001958_emphysema1.42758903
51MP0004215_abnormal_myocardial_fiber1.39232568
52MP0003283_abnormal_digestive_organ1.38917593
53MP0005646_abnormal_pituitary_gland1.38828880
54MP0002161_abnormal_fertility/fecundity1.38393263
55MP0002822_catalepsy1.36541798
56MP0005670_abnormal_white_adipose1.36260327
57MP0002067_abnormal_sensory_capabilities1.34113276
58MP0001970_abnormal_pain_threshold1.29942507
59MP0003633_abnormal_nervous_system1.29763661
60MP0003631_nervous_system_phenotype1.29644651
61MP0000013_abnormal_adipose_tissue1.29343268
62MP0003011_delayed_dark_adaptation1.28560549
63MP0002229_neurodegeneration1.25968037
64MP0002210_abnormal_sex_determination1.24840673
65MP0003632_abnormal_nervous_system1.23992879
66MP0001879_abnormal_lymphatic_vessel1.21991794
67MP0004134_abnormal_chest_morphology1.21609269
68MP0008569_lethality_at_weaning1.20890328
69MP0006276_abnormal_autonomic_nervous1.20524510
70MP0002733_abnormal_thermal_nociception1.18804705
71MP0003279_aneurysm1.17350661
72MP0008872_abnormal_physiological_respon1.16885372
73MP0002882_abnormal_neuron_morphology1.16503691
74MP0003638_abnormal_response/metabolism_1.15925442
75MP0001177_atelectasis1.15655984
76MP0000604_amyloidosis1.15358640
77MP0001963_abnormal_hearing_physiology1.14440855
78MP0002653_abnormal_ependyma_morphology1.13990636
79MP0003075_altered_response_to1.13895655
80MP0008874_decreased_physiological_sensi1.13814646
81MP0005377_hearing/vestibular/ear_phenot1.13672293
82MP0003878_abnormal_ear_physiology1.13672293
83MP0005595_abnormal_vascular_smooth1.13452786
84MP0005535_abnormal_body_temperature1.13389668
85MP0000566_synostosis1.12562054
86MP0001501_abnormal_sleep_pattern1.11446348
87MP0000465_gastrointestinal_hemorrhage1.09995645
88MP0002735_abnormal_chemical_nociception1.09636951
89MP0005623_abnormal_meninges_morphology1.08536615
90MP0001502_abnormal_circadian_rhythm1.07542249
91MP0006072_abnormal_retinal_apoptosis1.07263494
92MP0005253_abnormal_eye_physiology1.07013326
93MP0002557_abnormal_social/conspecific_i1.06970546
94MP0001145_abnormal_male_reproductive1.04390409
95MP0005394_taste/olfaction_phenotype1.04376203
96MP0005499_abnormal_olfactory_system1.04376203
97MP0008438_abnormal_cutaneous_collagen1.03817799
98MP0003724_increased_susceptibility_to1.03562654
99MP0000955_abnormal_spinal_cord1.02988539
100MP0005409_darkened_coat_color1.02607805
101MP0004924_abnormal_behavior1.02381728
102MP0005386_behavior/neurological_phenoty1.02381728
103MP0002066_abnormal_motor_capabilities/c1.02354315
104MP0002752_abnormal_somatic_nervous0.98831661
105MP0003787_abnormal_imprinting0.97875429
106MP0000343_altered_response_to0.97248301
107MP0000026_abnormal_inner_ear0.97024450
108MP0005666_abnormal_adipose_tissue0.95349672
109MP0000462_abnormal_digestive_system0.94338749
110MP0005645_abnormal_hypothalamus_physiol0.94329989
111MP0009250_abnormal_appendicular_skeleto0.94134411
112MP0005620_abnormal_muscle_contractility0.93927843
113MP0000653_abnormal_sex_gland0.93372063
114MP0004085_abnormal_heartbeat0.88177292
115MP0004811_abnormal_neuron_physiology0.86676787
116MP0002152_abnormal_brain_morphology0.85035260
117MP0005195_abnormal_posterior_eye0.83547230
118MP0002133_abnormal_respiratory_system0.81581167
119MP0005388_respiratory_system_phenotype0.81581167
120MP0002295_abnormal_pulmonary_circulatio0.80373186
121MP0001851_eye_inflammation0.80008871
122MP0008789_abnormal_olfactory_epithelium0.79350445
123MP0000631_abnormal_neuroendocrine_gland0.76072402
124MP0001765_abnormal_ion_homeostasis0.75629048
125MP0000049_abnormal_middle_ear0.74531411
126MP0004145_abnormal_muscle_electrophysio0.74093786
127MP0000681_abnormal_thyroid_gland0.74026983
128MP0000647_abnormal_sebaceous_gland0.73737616
129MP0000751_myopathy0.73306842
130MP0008775_abnormal_heart_ventricle0.72900175
131MP0002184_abnormal_innervation0.71279948
132MP0002090_abnormal_vision0.70831741
133MP0001986_abnormal_taste_sensitivity0.70593939
134MP0001188_hyperpigmentation0.69561785
135MP0005647_abnormal_sex_gland0.68961431
136MP0004147_increased_porphyrin_level0.68884156
137MP0001664_abnormal_digestion0.67990034
138MP0004036_abnormal_muscle_relaxation0.66305092
139MP0008260_abnormal_autophagy0.66233859
140MP0001756_abnormal_urination0.65677417
141MP0004858_abnormal_nervous_system0.64831886
142MP0002638_abnormal_pupillary_reflex0.63692270
143MP0005379_endocrine/exocrine_gland_phen0.63519427

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)8.01729087
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.01729087
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.75084763
4Abnormal respiratory motile cilium physiology (HP:0012261)5.92157278
5Abnormal respiratory motile cilium morphology (HP:0005938)5.72537438
6Abnormal respiratory epithelium morphology (HP:0012253)5.72537438
7Abnormal ciliary motility (HP:0012262)5.19146846
8Prolonged bleeding time (HP:0003010)5.01094550
9Neurofibrillary tangles (HP:0002185)4.87455676
10Abnormality of binocular vision (HP:0011514)4.82093324
11Diplopia (HP:0000651)4.82093324
12Febrile seizures (HP:0002373)4.76445767
13Atonic seizures (HP:0010819)4.40419945
14Action tremor (HP:0002345)4.38796868
15Rhinitis (HP:0012384)4.37764311
16Purpura (HP:0000979)4.16855093
17Aortic aneurysm (HP:0004942)4.12207377
18Increased mean platelet volume (HP:0011877)4.11356735
19Menorrhagia (HP:0000132)4.06072182
20Degeneration of the lateral corticospinal tracts (HP:0002314)3.89494423
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.89494423
22Petechiae (HP:0000967)3.83733113
23Abnormal platelet volume (HP:0011876)3.72899603
24Chronic bronchitis (HP:0004469)3.71392510
25Focal seizures (HP:0007359)3.70892293
26Papilledema (HP:0001085)3.68278044
27Abnormal eating behavior (HP:0100738)3.65064274
28Cerebral inclusion bodies (HP:0100314)3.58525872
29Infertility (HP:0000789)3.57195884
30Hyperlipoproteinemia (HP:0010980)3.32012306
31Poor eye contact (HP:0000817)3.07524900
32Aplasia involving bones of the upper limbs (HP:0009823)3.06731129
33Aplasia of the phalanges of the hand (HP:0009802)3.06731129
34Aplasia involving bones of the extremities (HP:0009825)3.06731129
35Medial flaring of the eyebrow (HP:0010747)3.05204078
36Ventricular fibrillation (HP:0001663)3.03040997
37Epistaxis (HP:0000421)3.02455427
38Nephronophthisis (HP:0000090)2.87348620
39Acute necrotizing encephalopathy (HP:0006965)2.83212894
40Annular pancreas (HP:0001734)2.81210420
41Genetic anticipation (HP:0003743)2.80624620
42Retinal dysplasia (HP:0007973)2.69781357
43Abnormality of the corticospinal tract (HP:0002492)2.69290470
44Absence seizures (HP:0002121)2.66999223
45Parakeratosis (HP:0001036)2.66884818
46Postural instability (HP:0002172)2.61897549
47Palpebral edema (HP:0100540)2.60650129
48Obstructive sleep apnea (HP:0002870)2.59807512
49Myokymia (HP:0002411)2.59305382
50Torticollis (HP:0000473)2.58716595
51Bundle branch block (HP:0011710)2.56098636
52Peripheral hypomyelination (HP:0007182)2.53264713
53Supranuclear gaze palsy (HP:0000605)2.52729106
54Hemiplegia (HP:0002301)2.52218224
55Visual hallucinations (HP:0002367)2.49028734
56Megalencephaly (HP:0001355)2.45800404
57Abnormal mitochondria in muscle tissue (HP:0008316)2.41006582
58Progressive macrocephaly (HP:0004481)2.37281088
59Acute encephalopathy (HP:0006846)2.36717004
60Leukodystrophy (HP:0002415)2.36185598
61Gait imbalance (HP:0002141)2.35921031
62Hemiparesis (HP:0001269)2.34875056
63Conjunctival telangiectasia (HP:0000524)2.33092790
64Abnormality of the renal medulla (HP:0100957)2.32922237
65Polyphagia (HP:0002591)2.32753823
66Urinary bladder sphincter dysfunction (HP:0002839)2.32627743
67Scanning speech (HP:0002168)2.32103264
68Vaginal atresia (HP:0000148)2.31452621
69Truncal ataxia (HP:0002078)2.30731215
70Abnormality of glycolysis (HP:0004366)2.30322424
71Increased serum pyruvate (HP:0003542)2.30322424
72Generalized tonic-clonic seizures (HP:0002069)2.27432845
73Genital tract atresia (HP:0001827)2.27432147
74Dialeptic seizures (HP:0011146)2.27064105
75Congenital primary aphakia (HP:0007707)2.24853356
76Focal motor seizures (HP:0011153)2.23774123
77Sensory axonal neuropathy (HP:0003390)2.22484021
78Heart block (HP:0012722)2.21377920
79Clumsiness (HP:0002312)2.19240343
80Increased variability in muscle fiber diameter (HP:0003557)2.15979721
81Cholecystitis (HP:0001082)2.11657635
82Abnormal gallbladder physiology (HP:0012438)2.11657635
83Abnormal social behavior (HP:0012433)2.10930581
84Impaired social interactions (HP:0000735)2.10930581
85Dyschromatopsia (HP:0007641)2.09881462
86Urinary urgency (HP:0000012)2.09328850
87Acute lymphatic leukemia (HP:0006721)2.08985146
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.08595743
89Nephrogenic diabetes insipidus (HP:0009806)2.08549195
90Mitochondrial inheritance (HP:0001427)2.06763944
91Abnormal atrioventricular conduction (HP:0005150)2.05055131
92Abnormal EKG (HP:0003115)2.04703068
93Bronchiectasis (HP:0002110)2.03341122
94Impaired platelet aggregation (HP:0003540)2.03134575
95Abnormal platelet function (HP:0011869)2.03134575
96Stereotypic behavior (HP:0000733)2.02810622
97Broad metatarsal (HP:0001783)2.02718704
98Neonatal short-limb short stature (HP:0008921)2.02628488
99Clonus (HP:0002169)2.02302897
100Focal dystonia (HP:0004373)2.02133272
101Termporal pattern (HP:0011008)2.01259749
102Insidious onset (HP:0003587)2.01259749
103Absent speech (HP:0001344)2.00575190
104Abnormality of the dental root (HP:0006486)2.00065223
105Taurodontia (HP:0000679)2.00065223
106Abnormality of permanent molar morphology (HP:0011071)2.00065223
107Male infertility (HP:0003251)1.99768020
108Impaired vibration sensation in the lower limbs (HP:0002166)1.99605473
109Gingival bleeding (HP:0000225)1.99513426
110Optic disc pallor (HP:0000543)1.98803562
111Gaze-evoked nystagmus (HP:0000640)1.98285668
112Muscle fiber splitting (HP:0003555)1.97900122
113Decreased central vision (HP:0007663)1.96883808
114Epileptic encephalopathy (HP:0200134)1.96258214
115Tubulointerstitial nephritis (HP:0001970)1.96113072
116Abnormality of the dental pulp (HP:0006479)1.95945200
117Aplasia/Hypoplasia of the lens (HP:0008063)1.95556106
118Anxiety (HP:0000739)1.95553732
119Pheochromocytoma (HP:0002666)1.95532532
120Broad-based gait (HP:0002136)1.94952977
121Abnormality of renal resorption (HP:0011038)1.94659585
122Dysdiadochokinesis (HP:0002075)1.94438920
123Spastic gait (HP:0002064)1.93372227
124Polydipsia (HP:0001959)1.92635113
125Abnormal drinking behavior (HP:0030082)1.92635113
126Spontaneous hematomas (HP:0007420)1.91790942
127Abnormality of molar morphology (HP:0011070)1.90981170
128Abnormality of molar (HP:0011077)1.90981170
129Hypoplastic left heart (HP:0004383)1.90858779
130Vascular tortuosity (HP:0004948)1.89843823
131Hyporeflexia of lower limbs (HP:0002600)1.89395688
132Ulnar claw (HP:0001178)1.89033283
133Craniofacial dystonia (HP:0012179)1.87036592
134Hypokalemic alkalosis (HP:0001949)1.86290767
135Abnormality of skeletal muscle fiber size (HP:0012084)1.86083874
136Dysmetria (HP:0001310)1.85989888
137Mild short stature (HP:0003502)1.83966410
138Hypoplasia of the iris (HP:0007676)1.83668488
139Neuroendocrine neoplasm (HP:0100634)1.82875083
140Molar tooth sign on MRI (HP:0002419)1.82774775
141Abnormality of midbrain morphology (HP:0002418)1.82774775
142Widely spaced teeth (HP:0000687)1.81636744
143Methylmalonic acidemia (HP:0002912)1.81556976
144Primary atrial arrhythmia (HP:0001692)1.81081865
145Abnormal pupillary function (HP:0007686)1.79874587
146Hypoplastic pelvis (HP:0008839)1.79788583
147Nonprogressive disorder (HP:0003680)1.78255215
148Metabolic alkalosis (HP:0200114)1.75405034
149Abnormality of the vasculature of the conjunctiva (HP:0008054)1.75008651
150Spinal canal stenosis (HP:0003416)1.74412928
151Type 1 muscle fiber predominance (HP:0003803)1.74238784
152Humeroradial synostosis (HP:0003041)1.73583314
153Synostosis involving the elbow (HP:0003938)1.73583314
154Prolonged QT interval (HP:0001657)1.73289603
155Abnormality of the middle phalanges of the toes (HP:0010183)1.72822280
156Narrow nasal bridge (HP:0000446)1.72593673
157Type II lissencephaly (HP:0007260)1.72245518
158Split foot (HP:0001839)1.72067431
159Abnormality of the phalanges of the 2nd finger (HP:0009541)1.70438330
160Intention tremor (HP:0002080)1.69888480
161Nasal polyposis (HP:0100582)1.69537729
162Sleep apnea (HP:0010535)1.68863068
163Tubulointerstitial abnormality (HP:0001969)1.68654672
164Ankle clonus (HP:0011448)1.67893879
165Increased circulating renin level (HP:0000848)1.66762732
166Morphological abnormality of the inner ear (HP:0011390)1.66006424
167Renal Fanconi syndrome (HP:0001994)1.65334140
168Abnormality of renal excretion (HP:0011036)1.64317079
169Progressive cerebellar ataxia (HP:0002073)1.64080717
170Hyperventilation (HP:0002883)1.62263206
171Lower limb muscle weakness (HP:0007340)1.62007889
172Short femoral neck (HP:0100864)1.60014651
173Abnormal urine output (HP:0012590)1.59923585
174Spastic tetraparesis (HP:0001285)1.58766746
175Tubular atrophy (HP:0000092)1.58530550
176Hypomagnesemia (HP:0002917)1.57799090
177Delusions (HP:0000746)1.57515605
178Polyuria (HP:0000103)1.57295676
179Choroideremia (HP:0001139)1.56639483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.95593011
2PDK34.32347231
3PDK44.32347231
4MAP4K23.71660855
5WNK43.02130914
6DAPK23.01148655
7PDK22.94864216
8PRKD32.91310281
9OXSR12.84258417
10MYLK2.76334479
11MAPKAPK52.50084144
12EPHA42.48945177
13PNCK2.37868244
14CASK2.23868249
15TESK12.21872466
16PBK2.17106717
17TNIK2.01484298
18MUSK1.98722851
19CAMKK21.86702497
20CAMKK11.78384179
21ICK1.70122951
22MST41.64807946
23NTRK21.63377787
24PTK2B1.62909490
25LMTK21.56430421
26CAMK11.52756426
27PKN11.50573124
28DMPK1.49439875
29MAPKAPK31.46744122
30WNK11.46201324
31FES1.37248175
32PHKG11.37175072
33PHKG21.37175072
34BCR1.36296814
35EPHB11.30209764
36PIK3CG1.28819361
37CDK191.28172357
38TAOK31.26480163
39DAPK31.25913033
40NUAK11.19276116
41SGK21.15520758
42MAP2K71.12038709
43SGK4941.11326611
44SGK2231.11326611
45NTRK11.10966693
46BMPR1B1.09675027
47MARK11.08926560
48FRK1.08559773
49MAP3K41.08405620
50BMX1.07643769
51UHMK11.07163453
52NEK61.06106232
53KIT1.04211019
54CAMK2B1.03327699
55TIE11.03131145
56CAMK2A1.02297361
57NTRK31.01796882
58FGFR20.98045241
59MAPK150.98035874
60TEC0.94532547
61ILK0.93807387
62DAPK10.90607775
63RIPK10.90362140
64MET0.89650641
65PRKG20.88606242
66MAPK130.88495999
67TYRO30.86969806
68PAK20.85740955
69ROCK20.85121513
70PINK10.84948839
71CAMK2D0.84669095
72CDK50.82025797
73SYK0.81258274
74FGR0.81120624
75RAF10.78210199
76LIMK10.78028567
77EPHB20.77398620
78LATS10.75534474
79ROCK10.75443142
80KSR20.72779547
81PRKCG0.72566477
82CSNK1G20.72120503
83MAPK40.71374876
84CAMK2G0.71355688
85TESK20.70217336
86CDK150.69964965
87CDK140.69577921
88DYRK20.68400393
89CDK180.67949255
90NME10.67776877
91GRK10.67630199
92CSNK1G30.66997418
93GRK50.66610639
94PRKCE0.65849804
95GRK70.65264044
96WNK30.64561016
97PAK60.63858858
98MINK10.63622370
99PDPK10.62746569
100MARK20.62056973
101CDK11A0.61192832
102LATS20.61101939
103BMPR20.60755691
104PDK10.60595217
105PAK30.59623316
106SGK30.59162760
107HIPK20.56648729
108ADRBK20.56474827
109PLK20.55938669
110MAP3K130.55893203
111ARAF0.55346235
112CDK30.53663004
113PRKCQ0.53599097
114SGK10.52835717
115OBSCN0.51992721
116DYRK1A0.51100639
117PAK10.50538180
118MAPK70.50476232
119IRAK20.49965413
120PRPF4B0.49094963
121PRKG10.48319954
122CSF1R0.46614386
123PRKACA0.46029963
124MAP2K10.45567913
125BTK0.43899196
126CSNK1A1L0.43824545
127SIK20.42479374
128TGFBR20.42319341
129STK380.42245574
130RPS6KA30.41970885
131STK160.41434644
132ADRBK10.40708365
133CLK10.40169368
134RIPK40.39505742
135CSNK1G10.38459802
136CAMK1G0.37791568
137PRKD10.36063391
138PRKACB0.35537334
139MAPK120.30450300
140TNK20.30089344
141PRKCA0.29948002
142IRAK10.29838803
143MAP2K40.27377176
144CSNK1D0.27250982
145CSNK1A10.26872577

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.20494408
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.10578992
3Fatty acid elongation_Homo sapiens_hsa000622.89928767
4Fatty acid biosynthesis_Homo sapiens_hsa000612.65571716
5Steroid biosynthesis_Homo sapiens_hsa001002.60305361
6Parkinsons disease_Homo sapiens_hsa050122.47647607
7Ether lipid metabolism_Homo sapiens_hsa005652.40710125
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37021532
9Vitamin B6 metabolism_Homo sapiens_hsa007502.29807064
10Alzheimers disease_Homo sapiens_hsa050102.18906915
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.03799039
12Platelet activation_Homo sapiens_hsa046111.99348573
13Huntingtons disease_Homo sapiens_hsa050161.97883983
14Propanoate metabolism_Homo sapiens_hsa006401.96540113
15Cardiac muscle contraction_Homo sapiens_hsa042601.96043131
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91388128
17Collecting duct acid secretion_Homo sapiens_hsa049661.89994292
18Pyruvate metabolism_Homo sapiens_hsa006201.88891588
19Linoleic acid metabolism_Homo sapiens_hsa005911.88758728
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88393233
21Sulfur metabolism_Homo sapiens_hsa009201.84487984
22Nicotine addiction_Homo sapiens_hsa050331.81881468
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76351960
24Gap junction_Homo sapiens_hsa045401.72802109
25Nitrogen metabolism_Homo sapiens_hsa009101.63834365
26Glutamatergic synapse_Homo sapiens_hsa047241.56223992
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52088930
28GABAergic synapse_Homo sapiens_hsa047271.46973391
29Fatty acid metabolism_Homo sapiens_hsa012121.43784769
30Amphetamine addiction_Homo sapiens_hsa050311.34950182
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33122851
32Synaptic vesicle cycle_Homo sapiens_hsa047211.32247079
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31324357
34Salivary secretion_Homo sapiens_hsa049701.26468542
35Sphingolipid metabolism_Homo sapiens_hsa006001.26255373
36ECM-receptor interaction_Homo sapiens_hsa045121.23999387
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22182879
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21920302
39Circadian entrainment_Homo sapiens_hsa047131.20555200
40Cocaine addiction_Homo sapiens_hsa050301.19412790
41Morphine addiction_Homo sapiens_hsa050321.19362346
42Mineral absorption_Homo sapiens_hsa049781.19153168
43Butanoate metabolism_Homo sapiens_hsa006501.17464610
44Renin secretion_Homo sapiens_hsa049241.15990656
45Serotonergic synapse_Homo sapiens_hsa047261.13489006
46Protein export_Homo sapiens_hsa030601.12618335
47Estrogen signaling pathway_Homo sapiens_hsa049151.10628828
48Gastric acid secretion_Homo sapiens_hsa049711.10320472
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09749242
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.06921803
51Dilated cardiomyopathy_Homo sapiens_hsa054141.06689807
52Taste transduction_Homo sapiens_hsa047421.03010881
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02348199
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98359075
55GnRH signaling pathway_Homo sapiens_hsa049120.95918745
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94823587
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.94648164
58Histidine metabolism_Homo sapiens_hsa003400.92874979
59Vibrio cholerae infection_Homo sapiens_hsa051100.92715891
60Dopaminergic synapse_Homo sapiens_hsa047280.89407562
61Insulin secretion_Homo sapiens_hsa049110.89351350
62Arachidonic acid metabolism_Homo sapiens_hsa005900.87531526
63Dorso-ventral axis formation_Homo sapiens_hsa043200.84259991
64Glioma_Homo sapiens_hsa052140.84059510
65Axon guidance_Homo sapiens_hsa043600.83907693
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83683758
67Olfactory transduction_Homo sapiens_hsa047400.83012334
68Glycerolipid metabolism_Homo sapiens_hsa005610.82917546
69Choline metabolism in cancer_Homo sapiens_hsa052310.82730769
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82345773
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81971827
72Calcium signaling pathway_Homo sapiens_hsa040200.81122043
73Long-term potentiation_Homo sapiens_hsa047200.80077579
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75930914
75Phototransduction_Homo sapiens_hsa047440.74222397
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73688499
77Basal transcription factors_Homo sapiens_hsa030220.73564851
78MAPK signaling pathway_Homo sapiens_hsa040100.73527290
79Long-term depression_Homo sapiens_hsa047300.72588521
80Ras signaling pathway_Homo sapiens_hsa040140.70541227
81Pancreatic secretion_Homo sapiens_hsa049720.70412270
82Fatty acid degradation_Homo sapiens_hsa000710.70349745
83Focal adhesion_Homo sapiens_hsa045100.69650877
84Arginine and proline metabolism_Homo sapiens_hsa003300.68432780
85Rap1 signaling pathway_Homo sapiens_hsa040150.66434182
86Metabolic pathways_Homo sapiens_hsa011000.65282030
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.64851126
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62600571
89PPAR signaling pathway_Homo sapiens_hsa033200.62325128
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61862183
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58668620
92Cholinergic synapse_Homo sapiens_hsa047250.58129299
93Inositol phosphate metabolism_Homo sapiens_hsa005620.57824764
94* Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57413097
95ErbB signaling pathway_Homo sapiens_hsa040120.56987984
96Hedgehog signaling pathway_Homo sapiens_hsa043400.56555891
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55444821
98Glucagon signaling pathway_Homo sapiens_hsa049220.53795817
99Circadian rhythm_Homo sapiens_hsa047100.52581569
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52525748
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52161147
102VEGF signaling pathway_Homo sapiens_hsa043700.52023987
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51303666
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51062169
105Endocytosis_Homo sapiens_hsa041440.50540617
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.48744775
107cAMP signaling pathway_Homo sapiens_hsa040240.48024962
108Peroxisome_Homo sapiens_hsa041460.47691243
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47685835
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47528746
111Rheumatoid arthritis_Homo sapiens_hsa053230.47513936
112Regulation of autophagy_Homo sapiens_hsa041400.47355993
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46911702
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44543251
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44016221
116Tight junction_Homo sapiens_hsa045300.41337947
117Thyroid hormone synthesis_Homo sapiens_hsa049180.38802615
118Amoebiasis_Homo sapiens_hsa051460.36623164
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.36452480
120Oxytocin signaling pathway_Homo sapiens_hsa049210.36023720
121Protein digestion and absorption_Homo sapiens_hsa049740.34381362
122Chemokine signaling pathway_Homo sapiens_hsa040620.34300903
123African trypanosomiasis_Homo sapiens_hsa051430.34254605
124Prion diseases_Homo sapiens_hsa050200.34130020
125Bile secretion_Homo sapiens_hsa049760.33919021
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33870650
127Melanogenesis_Homo sapiens_hsa049160.33820625
128* Glutathione metabolism_Homo sapiens_hsa004800.33691413
129ABC transporters_Homo sapiens_hsa020100.33257123
130Carbon metabolism_Homo sapiens_hsa012000.33055630
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.33044198
132Ovarian steroidogenesis_Homo sapiens_hsa049130.33019756
133Alcoholism_Homo sapiens_hsa050340.32957364
134Fructose and mannose metabolism_Homo sapiens_hsa000510.32838389
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31898073
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31656006
137Type II diabetes mellitus_Homo sapiens_hsa049300.30049113

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