GSTO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.05507172
2protein maturation by protein folding (GO:0022417)3.97319678
3neutrophil activation involved in immune response (GO:0002283)3.78449925
4glycosphingolipid catabolic process (GO:0046479)3.68669370
5viral transcription (GO:0019083)3.68049809
6pentose-phosphate shunt (GO:0006098)3.64838694
7translational termination (GO:0006415)3.60059493
8ethanol oxidation (GO:0006069)3.57483969
9interferon-gamma secretion (GO:0072643)3.55993534
10NADPH regeneration (GO:0006740)3.52110821
11pinocytosis (GO:0006907)3.42744836
12DNA deamination (GO:0045006)3.37119411
13cellular response to thyroid hormone stimulus (GO:0097067)3.36240453
14glycolipid catabolic process (GO:0019377)3.34400390
15oligosaccharide catabolic process (GO:0009313)3.32060364
16translational elongation (GO:0006414)3.28109678
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22681871
18response to thyroid hormone (GO:0097066)3.22372467
19hemidesmosome assembly (GO:0031581)3.19936729
20ribosomal small subunit biogenesis (GO:0042274)3.19025795
21Arp2/3 complex-mediated actin nucleation (GO:0034314)3.15060229
22protein targeting to ER (GO:0045047)3.13663052
23response to peptidoglycan (GO:0032494)3.13304036
24maturation of SSU-rRNA (GO:0030490)3.13037965
254-hydroxyproline metabolic process (GO:0019471)3.10520041
26cotranslational protein targeting to membrane (GO:0006613)3.10137395
27primary alcohol catabolic process (GO:0034310)3.10077160
28regulation of cholesterol esterification (GO:0010872)3.09624344
29AMP metabolic process (GO:0046033)3.09486178
30formation of translation preinitiation complex (GO:0001731)3.07544170
31cellular response to zinc ion (GO:0071294)3.07000292
32positive regulation of osteoblast proliferation (GO:0033690)3.06901008
33protein localization to endoplasmic reticulum (GO:0070972)3.00800742
34ethanol metabolic process (GO:0006067)2.98506140
35one-carbon compound transport (GO:0019755)2.97528973
36establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94705278
37viral life cycle (GO:0019058)2.91469737
38translational initiation (GO:0006413)2.90685221
39regulation of superoxide anion generation (GO:0032928)2.89792075
40L-phenylalanine metabolic process (GO:0006558)2.89549098
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.89549098
42ceramide catabolic process (GO:0046514)2.88804335
43regulation of mononuclear cell migration (GO:0071675)2.87525095
44maintenance of gastrointestinal epithelium (GO:0030277)2.86849336
45regulation of cytokine secretion involved in immune response (GO:0002739)2.86208340
46fibrinolysis (GO:0042730)2.84497456
47negative regulation of nitric oxide biosynthetic process (GO:0045019)2.82936182
48peptidyl-proline hydroxylation (GO:0019511)2.82049214
49cell adhesion mediated by integrin (GO:0033627)2.80740973
50purine nucleotide salvage (GO:0032261)2.80601652
51proteasome assembly (GO:0043248)2.77403149
52hyaluronan catabolic process (GO:0030214)2.75416586
53myeloid cell homeostasis (GO:0002262)2.74305125
54cyclooxygenase pathway (GO:0019371)2.74148285
55cellular response to oxygen radical (GO:0071450)2.74041920
56removal of superoxide radicals (GO:0019430)2.74041920
57cellular response to superoxide (GO:0071451)2.74041920
58aldehyde catabolic process (GO:0046185)2.73549485
59positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.73460881
60barbed-end actin filament capping (GO:0051016)2.73097921
61cellular protein complex disassembly (GO:0043624)2.72882317
62negative regulation of myeloid cell apoptotic process (GO:0033033)2.72499351
63negative regulation of interleukin-12 production (GO:0032695)2.71712184
64lipopolysaccharide-mediated signaling pathway (GO:0031663)2.71374304
65bundle of His cell to Purkinje myocyte communication (GO:0086069)2.70858350
66glucose catabolic process (GO:0006007)2.70247241
67regulation of metalloenzyme activity (GO:0048552)2.70099862
68nucleobase-containing small molecule interconversion (GO:0015949)2.69374183
69negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68325755
70ribosomal large subunit biogenesis (GO:0042273)2.65890527
71protein autoprocessing (GO:0016540)2.65515883
72positive regulation of monocyte chemotaxis (GO:0090026)2.64853972
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.64834510
74amino sugar catabolic process (GO:0046348)2.64824557
75nitric oxide biosynthetic process (GO:0006809)2.64272597
76regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63891005
77folic acid transport (GO:0015884)2.62364594
78negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.60939750
79negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.57795508
80sulfur amino acid catabolic process (GO:0000098)2.57492604
81protein retention in ER lumen (GO:0006621)2.57288099
82nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.55273641
83immunoglobulin mediated immune response (GO:0016064)2.55117615
84regulation of cellular amino acid metabolic process (GO:0006521)2.52543060
85retinoic acid metabolic process (GO:0042573)2.52017369
86diterpenoid biosynthetic process (GO:0016102)2.51334958
87positive regulation of fatty acid biosynthetic process (GO:0045723)2.50904009
88heme metabolic process (GO:0042168)2.50259381
89regulation of natural killer cell differentiation (GO:0032823)2.50235335
90cellular aldehyde metabolic process (GO:0006081)2.50231801
91deoxyribose phosphate biosynthetic process (GO:0046385)2.49172388
922-deoxyribonucleotide biosynthetic process (GO:0009265)2.49172388
93erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.47707051
94L-phenylalanine catabolic process (GO:0006559)2.47707051
95galactose catabolic process (GO:0019388)2.47380913
96regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.47100949
97maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.46722537
98Golgi transport vesicle coating (GO:0048200)2.45938405
99COPI coating of Golgi vesicle (GO:0048205)2.45938405
100flavonoid metabolic process (GO:0009812)2.45701017
101nucleoside salvage (GO:0043174)2.45157018
102chondrocyte proliferation (GO:0035988)2.45123975
103low-density lipoprotein particle clearance (GO:0034383)2.44623579
104positive regulation of chemokine biosynthetic process (GO:0045080)2.44141221
105NADP metabolic process (GO:0006739)2.42664932
106regulation of vitamin D biosynthetic process (GO:0060556)2.42133063
107negative regulation of mitochondrion organization (GO:0010823)2.41982758
108positive regulation of lipoprotein lipase activity (GO:0051006)2.40981156
109positive regulation of triglyceride lipase activity (GO:0061365)2.40981156
110membrane lipid catabolic process (GO:0046466)2.39314723
111antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.39222271
112fibril organization (GO:0097435)2.39130181
113T cell apoptotic process (GO:0070231)2.38846357
114UDP-N-acetylglucosamine metabolic process (GO:0006047)2.38611577
115hepatocyte differentiation (GO:0070365)2.38561729
116vitamin A metabolic process (GO:0006776)2.38530733
117response to nitrosative stress (GO:0051409)2.38395757
118regulation of protein heterodimerization activity (GO:0043497)2.38294586
119sphingolipid catabolic process (GO:0030149)2.37994218
120regulation of interleukin-8 secretion (GO:2000482)2.37977127
121purine-containing compound salvage (GO:0043101)2.37619556
122retinal metabolic process (GO:0042574)2.37389960
123eosinophil chemotaxis (GO:0048245)2.37324947
124lipoxygenase pathway (GO:0019372)2.36983426
125antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.36856251
126regulation of proton transport (GO:0010155)2.36389929
127response to interferon-beta (GO:0035456)2.36136933
128protein targeting to membrane (GO:0006612)2.35636082
129extracellular fibril organization (GO:0043206)2.35189697
130NIK/NF-kappaB signaling (GO:0038061)2.34289536
131antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.33591491
132translation (GO:0006412)2.32790634
133fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.32435184
134* glutathione derivative metabolic process (GO:1901685)2.30628824
135* glutathione derivative biosynthetic process (GO:1901687)2.30628824
136protein hydroxylation (GO:0018126)2.30570792
137mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.30465499
138pentose metabolic process (GO:0019321)2.30118627
139protein localization to endosome (GO:0036010)2.29800925
140negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.29519994
141negative regulation of fibrinolysis (GO:0051918)2.28825024
142epoxygenase P450 pathway (GO:0019373)2.28417114
143cellular response to cadmium ion (GO:0071276)2.28040945
144defense response to fungus (GO:0050832)2.27797989
145folic acid metabolic process (GO:0046655)2.27340044
146positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.27060859
147regulation of vitamin metabolic process (GO:0030656)2.26998771
148cysteine metabolic process (GO:0006534)2.26985488
149nucleotide salvage (GO:0043173)2.26749659
150peptide catabolic process (GO:0043171)2.26234143
151folic acid-containing compound biosynthetic process (GO:0009396)2.25907755
152regulation of chemokine biosynthetic process (GO:0045073)2.25804612
153wound healing, spreading of epidermal cells (GO:0035313)2.25445646
154negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.22175487
155negative regulation of ligase activity (GO:0051352)2.22175487
156triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.21952405
157hydrogen peroxide catabolic process (GO:0042744)2.21793689
158negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.21674729
159protein complex disassembly (GO:0043241)2.21662786
160type B pancreatic cell proliferation (GO:0044342)2.21642596
161pyrimidine nucleoside salvage (GO:0043097)2.21552705
162pyrimidine-containing compound salvage (GO:0008655)2.21552705
163fat-soluble vitamin biosynthetic process (GO:0042362)2.21453795
164carnitine metabolic process (GO:0009437)2.20974059
165lymphocyte apoptotic process (GO:0070227)2.20574906
166regulation of mitochondrial membrane potential (GO:0051881)2.20449010
167glycoside metabolic process (GO:0016137)2.20293180
168heme biosynthetic process (GO:0006783)2.20195497
169positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.19993935
170mature B cell differentiation involved in immune response (GO:0002313)2.19930061
171regulation of superoxide metabolic process (GO:0090322)2.19095420
172regulation of integrin-mediated signaling pathway (GO:2001044)2.18518181
173phagocytosis, engulfment (GO:0006911)2.17712203
174phospholipid efflux (GO:0033700)2.15948895
175GDP-mannose metabolic process (GO:0019673)2.15358889
176regulation of monocyte chemotaxis (GO:0090025)2.14546663
177negative regulation of coagulation (GO:0050819)2.13646467
178platelet degranulation (GO:0002576)2.13216809
179phagosome maturation (GO:0090382)2.13141727
180low-density lipoprotein particle remodeling (GO:0034374)2.12779354
181B cell mediated immunity (GO:0019724)2.12752193
182positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.12521863
183autophagic vacuole fusion (GO:0000046)2.11837379
184lipopolysaccharide metabolic process (GO:0008653)2.11392909
185macrophage differentiation (GO:0030225)2.11123337

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.45033303
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.89349483
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47001535
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.43944966
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.32279399
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.25561193
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.92380879
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.87745584
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.75782692
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66974605
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.49109395
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.47621985
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.04183482
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03881211
15PPARA_22158963_ChIP-Seq_LIVER_Mouse1.96998138
16RXR_22158963_ChIP-Seq_LIVER_Mouse1.89229990
17STAT4_19710469_ChIP-ChIP_TH1__Mouse1.82022077
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80424361
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76041868
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74632755
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.74348004
22TFEB_21752829_ChIP-Seq_HELA_Human1.73655949
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.72928377
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.71989709
25* IRF8_27001747_Chip-Seq_BMDM_Mouse1.71225990
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69590115
27ZNF263_19887448_ChIP-Seq_K562_Human1.69043590
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65789378
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.65210286
30* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64907643
31CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.64318348
32AR_21909140_ChIP-Seq_LNCAP_Human1.63937331
33* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61003938
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58225686
35CLOCK_20551151_ChIP-Seq_293T_Human1.58224076
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57891344
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57194737
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56041845
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54324584
40* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53910959
41SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53402594
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53402594
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52258213
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52003404
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.51261897
46ATF3_27146783_Chip-Seq_COLON_Human1.49560784
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48797600
48DCP1A_22483619_ChIP-Seq_HELA_Human1.46704809
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45591348
50* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.45448848
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45140590
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44371898
53* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41897536
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40898827
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.40021131
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39930171
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.39773946
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39517060
59ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.38710016
60E2F7_22180533_ChIP-Seq_HELA_Human1.37433232
61XRN2_22483619_ChIP-Seq_HELA_Human1.36098580
62VDR_21846776_ChIP-Seq_THP-1_Human1.34919806
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34902244
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33826813
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33795530
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30009826
67SOX2_20726797_ChIP-Seq_SW620_Human1.28196224
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28054034
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27844394
70KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27714050
71VDR_24763502_ChIP-Seq_THP-1_Human1.27586675
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27470126
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.27178510
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27010504
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27001598
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26183637
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25335270
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.25126557
79* GATA4_25053715_ChIP-Seq_YYC3_Human1.24575340
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23743742
81RACK7_27058665_Chip-Seq_MCF-7_Human1.23237431
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22497703
83* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22486569
84SPI1_23127762_ChIP-Seq_K562_Human1.21766161
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20845268
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.20658339
87LXR_22158963_ChIP-Seq_LIVER_Mouse1.19344541
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18587052
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18452722
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18321525
91* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16820592
92IRF8_22096565_ChIP-ChIP_GC-B_Human1.16551709
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16348761
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16077628
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15969891
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15766126
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14130704
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13677991
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12806730
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11375703
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.11361952
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11014711
103* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10981553
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09599448
105PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08657096
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08446751
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08285906
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08058496
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.08007123
110P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06743775
111* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06264140
112LXR_22292898_ChIP-Seq_THP-1_Human1.06191560
113CDX2_20551321_ChIP-Seq_CACO-2_Human1.05597545
114* GATA6_25053715_ChIP-Seq_YYC3_Human1.05380621
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.04706584
116FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03673444
117BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02636679
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02128431
119* SRF_21415370_ChIP-Seq_HL-1_Mouse1.01945059
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01516518
121CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00191138
122KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99701822
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99653011
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99580723
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99102417
126GATA1_22025678_ChIP-Seq_K562_Human0.99033542
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.98845844
128* NCOR1_26117541_ChIP-Seq_K562_Human0.98725375
129* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98002758
130* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96830067
131PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96188073
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96095758
133GABP_19822575_ChIP-Seq_HepG2_Human0.94312952
134RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94038298
135ELK1_19687146_ChIP-ChIP_HELA_Human0.94035897
136* SPI1_23547873_ChIP-Seq_NB4_Human0.93958910
137SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93716008
138NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93531448
139SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93399891
140ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92711303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.32442497
2MP0008004_abnormal_stomach_pH3.15465298
3MP0003186_abnormal_redox_activity2.70954893
4MP0010352_gastrointestinal_tract_polyps2.70133223
5MP0003705_abnormal_hypodermis_morpholog2.61763202
6MP0006082_CNS_inflammation2.38243941
7MP0003303_peritoneal_inflammation2.37153060
8MP0002139_abnormal_hepatobiliary_system2.33176947
9MP0006054_spinal_hemorrhage2.32784517
10MP0005360_urolithiasis2.25918023
11MP0003566_abnormal_cell_adhesion2.16994928
12MP0008875_abnormal_xenobiotic_pharmacok2.12995704
13MP0001835_abnormal_antigen_presentation2.10848451
14MP0005083_abnormal_biliary_tract2.08053373
15MP0008438_abnormal_cutaneous_collagen2.06464683
16MP0005451_abnormal_body_composition2.05211084
17MP0003075_altered_response_to2.00024636
18MP0010234_abnormal_vibrissa_follicle1.93105662
19MP0009840_abnormal_foam_cell1.88074457
20MP0004510_myositis1.86032894
21MP0003172_abnormal_lysosome_physiology1.80779467
22MP0005085_abnormal_gallbladder_physiolo1.75352109
23MP0001666_abnormal_nutrient_absorption1.72508590
24MP0008260_abnormal_autophagy1.72355858
25MP0005023_abnormal_wound_healing1.70962349
26MP0003950_abnormal_plasma_membrane1.70203785
27MP0009379_abnormal_foot_pigmentation1.67621217
28MP0005000_abnormal_immune_tolerance1.65332824
29MP0005365_abnormal_bile_salt1.63487795
30MP0000604_amyloidosis1.59829857
31MP0002877_abnormal_melanocyte_morpholog1.59524405
32MP0000490_abnormal_crypts_of1.56738987
33MP0005275_abnormal_skin_tensile1.54282920
34MP0009384_cardiac_valve_regurgitation1.47900956
35MP0001790_abnormal_immune_system1.40381571
36MP0005387_immune_system_phenotype1.40381571
37MP0006036_abnormal_mitochondrial_physio1.39110133
38MP0003693_abnormal_embryo_hatching1.38485844
39MP0002452_abnormal_antigen_presenting1.38094010
40MP0005257_abnormal_intraocular_pressure1.37728313
41MP0000537_abnormal_urethra_morphology1.35441301
42MP0003436_decreased_susceptibility_to1.35403785
43MP0001873_stomach_inflammation1.34937106
44MP0003011_delayed_dark_adaptation1.34006234
45MP0000372_irregular_coat_pigmentation1.33533354
46MP0009785_altered_susceptibility_to1.31735666
47MP0000858_altered_metastatic_potential1.31491319
48MP0010155_abnormal_intestine_physiology1.30256817
49MP0005671_abnormal_response_to1.30016998
50MP0001545_abnormal_hematopoietic_system1.29074566
51MP0005397_hematopoietic_system_phenotyp1.29074566
52MP0004264_abnormal_extraembryonic_tissu1.28940012
53MP0004019_abnormal_vitamin_homeostasis1.28110815
54MP0005166_decreased_susceptibility_to1.27937889
55MP0003191_abnormal_cellular_cholesterol1.27005497
56MP0002723_abnormal_immune_serum1.26677963
57MP0002998_abnormal_bone_remodeling1.25567300
58MP0002060_abnormal_skin_morphology1.25162920
59MP0001853_heart_inflammation1.24964577
60MP0001958_emphysema1.23808653
61MP0002138_abnormal_hepatobiliary_system1.22970373
62MP0002254_reproductive_system_inflammat1.22474903
63MP0009697_abnormal_copulation1.20912893
64MP0003448_altered_tumor_morphology1.20148239
65MP0010368_abnormal_lymphatic_system1.17269292
66MP0003453_abnormal_keratinocyte_physiol1.16085964
67MP0005408_hypopigmentation1.13840352
68MP0002420_abnormal_adaptive_immunity1.11693119
69MP0001819_abnormal_immune_cell1.11335729
70MP0003279_aneurysm1.10384217
71MP0004957_abnormal_blastocyst_morpholog1.10073558
72MP0005319_abnormal_enzyme/_coenzyme1.09747471
73MP0009763_increased_sensitivity_to1.09345703
74MP0009053_abnormal_anal_canal1.06566438
75MP0010329_abnormal_lipoprotein_level1.03879872
76MP0002396_abnormal_hematopoietic_system1.00418824
77MP0010030_abnormal_orbit_morphology1.00055511
78MP0009333_abnormal_splenocyte_physiolog0.99537373
79MP0004947_skin_inflammation0.99501700
80MP0002132_abnormal_respiratory_system0.98282634
81MP0000343_altered_response_to0.98086749
82MP0004272_abnormal_basement_membrane0.97342522
83MP0000477_abnormal_intestine_morphology0.97023405
84MP0003195_calcinosis0.96950069
85MP0001800_abnormal_humoral_immune0.96722459
86MP0001243_abnormal_dermal_layer0.94802754
87MP0002405_respiratory_system_inflammati0.93688926
88MP0003656_abnormal_erythrocyte_physiolo0.93410709
89MP0000358_abnormal_cell_content/0.93148043
90MP0005058_abnormal_lysosome_morphology0.92437433
91MP0001216_abnormal_epidermal_layer0.91858868
92MP0009278_abnormal_bone_marrow0.90736156
93MP0009643_abnormal_urine_homeostasis0.89063109
94MP0008007_abnormal_cellular_replicative0.88536223
95MP0000685_abnormal_immune_system0.88387826
96MP0002419_abnormal_innate_immunity0.88138999
97MP0005165_increased_susceptibility_to0.88105037
98MP0000609_abnormal_liver_physiology0.87827307
99MP0000465_gastrointestinal_hemorrhage0.87819269
100MP0000750_abnormal_muscle_regeneration0.87453761
101MP0002796_impaired_skin_barrier0.87374648
102MP0005025_abnormal_response_to0.87328958
103MP0000467_abnormal_esophagus_morphology0.87270041
104MP0001533_abnormal_skeleton_physiology0.86723443
105MP0000015_abnormal_ear_pigmentation0.86483308
106MP0005464_abnormal_platelet_physiology0.86306517
107MP0000470_abnormal_stomach_morphology0.86277922
108MP0000598_abnormal_liver_morphology0.85602524
109MP0003300_gastrointestinal_ulcer0.85227930
110MP0009764_decreased_sensitivity_to0.85218453
111MP0005501_abnormal_skin_physiology0.84873623
112MP0005164_abnormal_response_to0.84297849
113MP0002148_abnormal_hypersensitivity_rea0.83881262
114MP0005266_abnormal_metabolism0.82839634
115MP0002429_abnormal_blood_cell0.81780489
116MP0002019_abnormal_tumor_incidence0.81417824
117MP0005084_abnormal_gallbladder_morpholo0.81307022
118MP0001663_abnormal_digestive_system0.79307429
119MP0001542_abnormal_bone_strength0.78624128
120MP0000716_abnormal_immune_system0.78268084
121MP0003252_abnormal_bile_duct0.77919807
122MP0008469_abnormal_protein_level0.77614929
123MP0001849_ear_inflammation0.75843161
124MP0002332_abnormal_exercise_endurance0.75786274
125MP0005332_abnormal_amino_acid0.75464337
126MP0003795_abnormal_bone_structure0.75368935
127MP0001845_abnormal_inflammatory_respons0.74367484
128MP0002295_abnormal_pulmonary_circulatio0.74118990
129MP0005167_abnormal_blood-brain_barrier0.73882083
130MP0003941_abnormal_skin_development0.73303811
131MP0000627_abnormal_mammary_gland0.73260707
132MP0000371_diluted_coat_color0.73062553
133MP0005376_homeostasis/metabolism_phenot0.72949904
134MP0005584_abnormal_enzyme/coenzyme_acti0.72561082
135MP0003091_abnormal_cell_migration0.72474558
136MP0002398_abnormal_bone_marrow0.71930582
137MP0000249_abnormal_blood_vessel0.71639425
138MP0003828_pulmonary_edema0.70661778
139MP0003724_increased_susceptibility_to0.70134304
140MP0004808_abnormal_hematopoietic_stem0.69884716
141MP0006035_abnormal_mitochondrial_morpho0.69879599
142MP0000689_abnormal_spleen_morphology0.69176251
143MP0005390_skeleton_phenotype0.68914836
144MP0005330_cardiomyopathy0.68900091
145MP0002090_abnormal_vision0.67329624
146MP0001764_abnormal_homeostasis0.66993811
147MP0002722_abnormal_immune_system0.66625153

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.48190576
2Abnormality of liposaccharide metabolism (HP:0010968)5.48190576
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.48190576
4Protrusio acetabuli (HP:0003179)4.08596161
5Systemic lupus erythematosus (HP:0002725)3.96202528
6Abnormality of cells of the erythroid lineage (HP:0012130)3.87561427
7Abnormal number of erythroid precursors (HP:0012131)3.80428839
8Right ventricular cardiomyopathy (HP:0011663)3.74417716
9Purpura (HP:0000979)3.59468792
10Premature rupture of membranes (HP:0001788)3.52838047
11Abnormality of macrophages (HP:0004311)3.45106196
12Atrophic scars (HP:0001075)3.43047605
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.42812700
14Abnormal hemoglobin (HP:0011902)3.42326382
15Dysostosis multiplex (HP:0000943)3.37222271
16Pustule (HP:0200039)3.31032649
17Ileus (HP:0002595)3.28361383
18Increased cerebral lipofuscin (HP:0011813)3.26188078
19Myocardial infarction (HP:0001658)3.04785623
20Hepatosplenomegaly (HP:0001433)3.01627786
21Loss of speech (HP:0002371)2.95232104
22Peritonitis (HP:0002586)2.86617774
23Vertebral compression fractures (HP:0002953)2.82557944
24Multiple enchondromatosis (HP:0005701)2.80375458
25Increased neuronal autofluorescent lipopigment (HP:0002074)2.80068562
26Amyloidosis (HP:0011034)2.79422422
27Axonal loss (HP:0003447)2.77276787
28Thrombocytosis (HP:0001894)2.74573827
29Abnormal gallbladder physiology (HP:0012438)2.73067580
30Cholecystitis (HP:0001082)2.73067580
31Trismus (HP:0000211)2.68299861
32Onycholysis (HP:0001806)2.62249058
33Oral leukoplakia (HP:0002745)2.62161170
34Recurrent abscess formation (HP:0002722)2.59250119
35Progressive neurologic deterioration (HP:0002344)2.57438271
36Cervical subluxation (HP:0003308)2.56820972
37Fragile skin (HP:0001030)2.52313032
38Prolonged neonatal jaundice (HP:0006579)2.45428125
39Abnormality of mucopolysaccharide metabolism (HP:0011020)2.44886794
40Abnormality of polysaccharide metabolism (HP:0011012)2.44886794
41Abnormality of glycosaminoglycan metabolism (HP:0004371)2.44886794
42Generalized aminoaciduria (HP:0002909)2.44151365
43Beaking of vertebral bodies (HP:0004568)2.43989234
44Abnormal platelet function (HP:0011869)2.43859422
45Impaired platelet aggregation (HP:0003540)2.43859422
46Epistaxis (HP:0000421)2.43290316
47Abnormal cartilage morphology (HP:0002763)2.40608957
48Recurrent bacterial skin infections (HP:0005406)2.39722748
49Nuclear cataract (HP:0100018)2.37630419
50Polycythemia (HP:0001901)2.35688468
51Urinary glycosaminoglycan excretion (HP:0003541)2.34724382
52Mucopolysacchariduria (HP:0008155)2.34724382
53Abnormality of the vasculature of the conjunctiva (HP:0008054)2.33455246
54Gastrointestinal dysmotility (HP:0002579)2.33335293
55Interstitial pulmonary disease (HP:0006530)2.32477833
56Osteolytic defects of the hand bones (HP:0009699)2.32423198
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.32423198
58Acute necrotizing encephalopathy (HP:0006965)2.28680701
59Abnormal mitochondria in muscle tissue (HP:0008316)2.28299332
60Reduced antithrombin III activity (HP:0001976)2.27171086
61Increased serum ferritin (HP:0003281)2.26678382
62Abnormality of the distal phalanges of the toes (HP:0010182)2.25257052
63Fragile nails (HP:0001808)2.24958711
64Macrocytic anemia (HP:0001972)2.24006805
65Complement deficiency (HP:0004431)2.23894398
66Menorrhagia (HP:0000132)2.23204555
67Xanthomatosis (HP:0000991)2.22772134
68Acute encephalopathy (HP:0006846)2.21971632
69Intrahepatic cholestasis (HP:0001406)2.20482005
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.20458529
71Autoimmune thrombocytopenia (HP:0001973)2.20406964
72Renal Fanconi syndrome (HP:0001994)2.20249356
73Abnormality of glutamine family amino acid metabolism (HP:0010902)2.19711866
74Abnormality of complement system (HP:0005339)2.19496647
75Aplastic anemia (HP:0001915)2.19483277
76Glomerulonephritis (HP:0000099)2.18953979
77Microretrognathia (HP:0000308)2.18053994
78Chronic obstructive pulmonary disease (HP:0006510)2.17702865
79Obstructive lung disease (HP:0006536)2.17702865
80Prolonged bleeding time (HP:0003010)2.17681955
81Aortic aneurysm (HP:0004942)2.17169327
82Gingival bleeding (HP:0000225)2.16659048
83Aortic dissection (HP:0002647)2.14331739
84Increased connective tissue (HP:0009025)2.13849064
85Tetraparesis (HP:0002273)2.13360447
86Hypobetalipoproteinemia (HP:0003563)2.12340000
87Mitochondrial inheritance (HP:0001427)2.11169244
88Vacuolated lymphocytes (HP:0001922)2.10493598
89Recurrent gram-negative bacterial infections (HP:0005420)2.10452218
90Hyperammonemia (HP:0001987)2.09669930
91Reticulocytopenia (HP:0001896)2.09121927
92Upper motor neuron abnormality (HP:0002127)2.08613670
93Eczematoid dermatitis (HP:0000976)2.08610724
94Increased serum pyruvate (HP:0003542)2.07939808
95Disinhibition (HP:0000734)2.05752223
96Milia (HP:0001056)2.04988761
97Short nail (HP:0001799)2.03179327
98Hepatocellular necrosis (HP:0001404)2.02715870
99Abnormality of glycolysis (HP:0004366)2.02169576
100Abnormal blistering of the skin (HP:0008066)2.01371828
101Petechiae (HP:0000967)2.01282154
102Abnormality of fatty-acid metabolism (HP:0004359)1.99680041
103Abnormality of iron homeostasis (HP:0011031)1.98576152
104Orthostatic hypotension (HP:0001278)1.98424374
105Distal lower limb muscle weakness (HP:0009053)1.98119929
106Alopecia of scalp (HP:0002293)1.97987547
107Hepatic necrosis (HP:0002605)1.97621083
108Pallor (HP:0000980)1.94288020
109Paralysis (HP:0003470)1.92661831
110Increased CSF lactate (HP:0002490)1.92433750
111Spastic diplegia (HP:0001264)1.92022379
112Palpitations (HP:0001962)1.91965976
113Abnormality of the common coagulation pathway (HP:0010990)1.91551327
114Conjunctival telangiectasia (HP:0000524)1.89171466
115Abnormal platelet volume (HP:0011876)1.89134685
116Esophageal neoplasm (HP:0100751)1.88589325
117Neoplasm of head and neck (HP:0012288)1.88589325
118Abnormality of the acetabulum (HP:0003170)1.87954718
119Bowed forearm bones (HP:0003956)1.87716828
120Bowing of the arm (HP:0006488)1.87716828
121Megaloblastic anemia (HP:0001889)1.87082507
122Abnormality of transition element cation homeostasis (HP:0011030)1.86846584
123Hypertensive crisis (HP:0100735)1.85972308
124Abnormalities of placenta or umbilical cord (HP:0001194)1.85492339
125Hydroxyprolinuria (HP:0003080)1.84691894
126Abnormality of proline metabolism (HP:0010907)1.84691894
127Exertional dyspnea (HP:0002875)1.84445786
128Rough bone trabeculation (HP:0100670)1.84366860
129Nonimmune hydrops fetalis (HP:0001790)1.83313701
130Micronodular cirrhosis (HP:0001413)1.82972158
131Flat acetabular roof (HP:0003180)1.82649573
132Abnormality of the Achilles tendon (HP:0005109)1.81717154
133Hypolipoproteinemia (HP:0010981)1.81606586
134Progressive macrocephaly (HP:0004481)1.81412061
135Nail dystrophy (HP:0008404)1.81229581
136Reduced subcutaneous adipose tissue (HP:0003758)1.80842180
137Deep venous thrombosis (HP:0002625)1.80794651
138Mucosal telangiectasiae (HP:0100579)1.80394690
139Cardiovascular calcification (HP:0011915)1.79935935
140Mutism (HP:0002300)1.79270744
141Dilatation of the ascending aorta (HP:0005111)1.78799088
142Elevated erythrocyte sedimentation rate (HP:0003565)1.78514611
143Abnormal trabecular bone morphology (HP:0100671)1.78086423
144Abnormality of the nasal mucosa (HP:0000433)1.78055789
145Ulnar bowing (HP:0003031)1.77873115
146Spinal rigidity (HP:0003306)1.77343497
147Difficulty climbing stairs (HP:0003551)1.76952159
148Multiple lipomas (HP:0001012)1.76155562
149Rhabdomyolysis (HP:0003201)1.75899081
150Dicarboxylic aciduria (HP:0003215)1.75286935
151Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75286935
152Ragged-red muscle fibers (HP:0003200)1.74988675
153Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74556734
154Respiratory failure (HP:0002878)1.74040016
155Abnormality of pyrimidine metabolism (HP:0004353)1.73583483
156Ventricular tachycardia (HP:0004756)1.73498360
157Biconcave vertebral bodies (HP:0004586)1.73409796
158Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73342365
159Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73342365
160Cerebral edema (HP:0002181)1.72596663
161Gout (HP:0001997)1.72009567
162Abnormality of the umbilical cord (HP:0010881)1.71692325
163Nausea (HP:0002018)1.70717644
164Esophageal varix (HP:0002040)1.69981535
165Congenital, generalized hypertrichosis (HP:0004540)1.69706836
166Mediastinal lymphadenopathy (HP:0100721)1.69631523
167Vascular calcification (HP:0004934)1.69616067
168Increased IgM level (HP:0003496)1.69445891
169Increased intramyocellular lipid droplets (HP:0012240)1.69161690
170Cerebral aneurysm (HP:0004944)1.68784883
171Ankle contracture (HP:0006466)1.68391049
172Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68297372
173Abnormality of the intrinsic pathway (HP:0010989)1.67679053
174Increased mean platelet volume (HP:0011877)1.67037173
175Hoarse voice (HP:0001609)1.66692831
176Hypoglycemic coma (HP:0001325)1.66030248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.47030640
2NME23.65417599
3PIM23.56702487
4TESK12.97545217
5TESK22.29066624
6TRIB32.25190956
7MST1R2.16640076
8PDK22.09326607
9PKN22.05659863
10MAP3K122.05178005
11TRPM71.97182929
12ERN11.93529783
13LRRK21.93141892
14MST41.92949464
15LIMK11.86076701
16MAP3K31.82056730
17MAP3K111.78372913
18MAPKAPK31.74152920
19VRK21.68127635
20RPS6KB21.62725168
21PAK41.62334137
22ERBB31.58047556
23KDR1.55405300
24TTN1.55095030
25BMPR21.54468347
26GRK71.54332470
27EIF2AK11.53416995
28MAP2K31.45079852
29SCYL21.43786161
30MYLK1.43706439
31FLT31.42963528
32RPS6KA41.38547953
33RIPK41.38506523
34TBK11.37160831
35BCKDK1.37070877
36PIK3CG1.25293631
37WEE11.21585687
38MAP3K141.19899462
39BUB11.19063097
40EIF2AK31.13530308
41STK101.13386167
42ZAP701.11492134
43TAOK21.10839589
44MAP3K81.09316732
45EEF2K1.09039014
46NEK91.08017943
47DAPK11.06494777
48PRKG21.04410870
49PTK61.04188652
50ABL21.03871506
51PTK21.02059077
52TGFBR11.00960474
53IRAK30.98475668
54EPHB20.97424243
55NEK10.96713894
56MET0.92825140
57PAK20.92472351
58DDR20.91369460
59PBK0.89550066
60LMTK20.86079714
61ERBB40.85945593
62DYRK30.85812998
63MAP2K20.83165634
64NME10.82628939
65FER0.81575596
66FRK0.80385284
67ILK0.80104007
68BRAF0.75902824
69STK160.75271739
70ACVR1B0.74464068
71PIK3CA0.72971519
72DAPK30.71982906
73FGR0.71420445
74CLK10.70726604
75MAP2K10.70301030
76PRPF4B0.70257136
77MAP3K50.70169739
78BMX0.70167160
79BLK0.69923329
80CSF1R0.69410487
81IRAK40.69279953
82TGFBR20.68993122
83PAK10.68263363
84ARAF0.66812417
85CDK60.66644458
86MAP3K10.65887314
87CSK0.65644999
88BRSK20.65538762
89TYK20.63623796
90PIM10.63545355
91MAP2K60.63425786
92IKBKB0.61907170
93AURKB0.61028569
94STK30.59257609
95TAOK10.57997270
96LATS20.57566405
97TEC0.56257680
98MATK0.53698239
99SYK0.52105408
100LYN0.49985662
101JAK30.49161008
102PRKCI0.44156676
103EPHB10.43993954
104VRK10.43426363
105GRK50.41746522
106PLK40.41511601
107STK40.40963473
108MAPKAPK20.40447792
109RIPK10.40102944
110IKBKE0.39871978
111MOS0.38603223
112LATS10.37787638
113CDK70.37458972
114ERBB20.37195756
115PDGFRA0.36829396
116KIT0.36570171
117STK38L0.36270603
118MAP4K10.35980575
119DYRK1B0.34983929
120MAP3K20.34729853
121MARK30.34634554
122PDPK10.34590624
123ZAK0.33430859
124AURKA0.32242437
125MAP3K130.31784954
126BTK0.31342223
127MAPKAPK50.30488132
128MAPK110.30462027
129PTK2B0.28600286
130CSNK1G30.28468332
131RAF10.28254811
132GSK3A0.28094339
133CSNK2A10.27220650
134CCNB10.26063114
135HCK0.25983648
136CAMK2G0.25458960
137ADRBK20.25118590
138PRKCD0.23992549

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.99588356
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.81414529
3Proteasome_Homo sapiens_hsa030502.72822670
4Lysosome_Homo sapiens_hsa041422.46544381
5* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.43569805
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.38762472
7* Glutathione metabolism_Homo sapiens_hsa004802.35002138
8* Chemical carcinogenesis_Homo sapiens_hsa052042.14647795
9Rheumatoid arthritis_Homo sapiens_hsa053232.07904199
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02497259
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01096778
12* Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99440428
13Staphylococcus aureus infection_Homo sapiens_hsa051501.96936283
14Asthma_Homo sapiens_hsa053101.82283065
15Pentose phosphate pathway_Homo sapiens_hsa000301.80404378
16Folate biosynthesis_Homo sapiens_hsa007901.78579777
17Sulfur relay system_Homo sapiens_hsa041221.73073290
18Caffeine metabolism_Homo sapiens_hsa002321.65932857
19Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.64213431
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.60070705
21Fatty acid degradation_Homo sapiens_hsa000711.57896071
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56452827
23Sulfur metabolism_Homo sapiens_hsa009201.56031348
24Allograft rejection_Homo sapiens_hsa053301.55452013
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55356601
26Carbon metabolism_Homo sapiens_hsa012001.45874814
27Fatty acid elongation_Homo sapiens_hsa000621.44743487
28DNA replication_Homo sapiens_hsa030301.43722535
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.42652728
30Histidine metabolism_Homo sapiens_hsa003401.41756466
31Retinol metabolism_Homo sapiens_hsa008301.41120745
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38232865
33p53 signaling pathway_Homo sapiens_hsa041151.35883371
34Phenylalanine metabolism_Homo sapiens_hsa003601.35005054
35Graft-versus-host disease_Homo sapiens_hsa053321.34136160
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33479665
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.30527630
38Fat digestion and absorption_Homo sapiens_hsa049751.27599236
39beta-Alanine metabolism_Homo sapiens_hsa004101.26582716
40Bladder cancer_Homo sapiens_hsa052191.26027601
41Phagosome_Homo sapiens_hsa041451.26005385
42Biosynthesis of amino acids_Homo sapiens_hsa012301.25223014
43Shigellosis_Homo sapiens_hsa051311.23520646
44Autoimmune thyroid disease_Homo sapiens_hsa053201.22905886
45Pyrimidine metabolism_Homo sapiens_hsa002401.21631623
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.21011270
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19589266
48Antigen processing and presentation_Homo sapiens_hsa046121.19576984
49Galactose metabolism_Homo sapiens_hsa000521.16982067
50Collecting duct acid secretion_Homo sapiens_hsa049661.16313211
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10777966
52Vibrio cholerae infection_Homo sapiens_hsa051101.08570454
53Osteoclast differentiation_Homo sapiens_hsa043801.07320483
54One carbon pool by folate_Homo sapiens_hsa006701.07108589
55Hematopoietic cell lineage_Homo sapiens_hsa046401.06290666
56Selenocompound metabolism_Homo sapiens_hsa004501.06283557
57Vitamin digestion and absorption_Homo sapiens_hsa049771.06177066
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.05934988
59Legionellosis_Homo sapiens_hsa051341.05658431
60Tuberculosis_Homo sapiens_hsa051521.04569140
61Small cell lung cancer_Homo sapiens_hsa052221.02366683
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00827050
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00162327
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99374616
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98331765
66Tyrosine metabolism_Homo sapiens_hsa003500.97487070
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96928245
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.96334893
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.95293814
70Alzheimers disease_Homo sapiens_hsa050100.94101954
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93946695
72Systemic lupus erythematosus_Homo sapiens_hsa053220.93321031
73Type I diabetes mellitus_Homo sapiens_hsa049400.92832949
74Arginine biosynthesis_Homo sapiens_hsa002200.92425252
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90331247
76Starch and sucrose metabolism_Homo sapiens_hsa005000.89689484
77Fructose and mannose metabolism_Homo sapiens_hsa000510.86910437
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86540239
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85897357
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82758832
81Apoptosis_Homo sapiens_hsa042100.81411999
82Arginine and proline metabolism_Homo sapiens_hsa003300.81319205
83RNA polymerase_Homo sapiens_hsa030200.80978569
84Huntingtons disease_Homo sapiens_hsa050160.80648166
85Arachidonic acid metabolism_Homo sapiens_hsa005900.79288275
86Tryptophan metabolism_Homo sapiens_hsa003800.78840289
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78248995
88Other glycan degradation_Homo sapiens_hsa005110.78011980
89Pertussis_Homo sapiens_hsa051330.77901538
90Mineral absorption_Homo sapiens_hsa049780.77893348
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77414623
92Thyroid cancer_Homo sapiens_hsa052160.76175582
93ECM-receptor interaction_Homo sapiens_hsa045120.73938765
94Peroxisome_Homo sapiens_hsa041460.73875389
95N-Glycan biosynthesis_Homo sapiens_hsa005100.73536918
96Renin-angiotensin system_Homo sapiens_hsa046140.73417419
97Prion diseases_Homo sapiens_hsa050200.73393948
98Leishmaniasis_Homo sapiens_hsa051400.73138216
99Sphingolipid metabolism_Homo sapiens_hsa006000.73084371
100Complement and coagulation cascades_Homo sapiens_hsa046100.70695601
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70652601
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70334329
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.69574320
104Pyruvate metabolism_Homo sapiens_hsa006200.65064632
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64277926
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62352331
107Salmonella infection_Homo sapiens_hsa051320.59925434
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59806373
109Propanoate metabolism_Homo sapiens_hsa006400.58998765
110Toxoplasmosis_Homo sapiens_hsa051450.57128748
111Herpes simplex infection_Homo sapiens_hsa051680.56041812
112PPAR signaling pathway_Homo sapiens_hsa033200.54329907
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54122523
114Malaria_Homo sapiens_hsa051440.53789266
115Influenza A_Homo sapiens_hsa051640.53565429
116Protein export_Homo sapiens_hsa030600.53525059
117Proteoglycans in cancer_Homo sapiens_hsa052050.52941518
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51483954
119Parkinsons disease_Homo sapiens_hsa050120.51393972
120RNA transport_Homo sapiens_hsa030130.51389083
121Vitamin B6 metabolism_Homo sapiens_hsa007500.50419417
122TNF signaling pathway_Homo sapiens_hsa046680.48924469
123African trypanosomiasis_Homo sapiens_hsa051430.48434186
124Oxidative phosphorylation_Homo sapiens_hsa001900.48223920
125Metabolic pathways_Homo sapiens_hsa011000.47585684
126Base excision repair_Homo sapiens_hsa034100.47492287
127Amoebiasis_Homo sapiens_hsa051460.47173552
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.46762690
129Viral myocarditis_Homo sapiens_hsa054160.43973801
130Adherens junction_Homo sapiens_hsa045200.42950447
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42587462
132Mismatch repair_Homo sapiens_hsa034300.42230500
133Fatty acid metabolism_Homo sapiens_hsa012120.41098711
134Focal adhesion_Homo sapiens_hsa045100.41026830
135HIF-1 signaling pathway_Homo sapiens_hsa040660.40056863
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.39142450

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