GSTO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.93773918
2cilium or flagellum-dependent cell motility (GO:0001539)9.84736574
3epithelial cilium movement (GO:0003351)9.69480760
4binding of sperm to zona pellucida (GO:0007339)9.66218264
5cell-cell recognition (GO:0009988)9.38496069
6plasma membrane fusion (GO:0045026)9.35338222
7spermatid development (GO:0007286)8.96482644
8piRNA metabolic process (GO:0034587)8.93871142
9reproduction (GO:0000003)8.87697126
10motile cilium assembly (GO:0044458)8.43388348
11cilium movement (GO:0003341)8.19870788
12synaptonemal complex organization (GO:0070193)8.01723796
13male meiosis (GO:0007140)7.87881061
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.40255500
15regulation of cilium movement (GO:0003352)7.28782013
16synaptonemal complex assembly (GO:0007130)7.24825959
17single fertilization (GO:0007338)7.16388990
18sperm capacitation (GO:0048240)6.84580464
19negative regulation of inclusion body assembly (GO:0090084)6.79034811
20spermatogenesis (GO:0007283)6.27892632
21male gamete generation (GO:0048232)6.25447862
22fertilization (GO:0009566)6.23902427
23DNA methylation involved in gamete generation (GO:0043046)5.92045723
24gamete generation (GO:0007276)5.82467445
25microtubule depolymerization (GO:0007019)5.70887530
26organic cation transport (GO:0015695)5.48729318
27ventricular system development (GO:0021591)5.31111619
28regulation of inclusion body assembly (GO:0090083)5.22469532
29germ cell development (GO:0007281)5.12684731
30calcium ion-dependent exocytosis (GO:0017156)5.10538273
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.10344922
32male meiosis I (GO:0007141)5.04024106
33microtubule severing (GO:0051013)4.88098948
34chromosome organization involved in meiosis (GO:0070192)4.84796083
35spermatid nucleus differentiation (GO:0007289)4.70237114
36cell recognition (GO:0008037)4.63469800
37multicellular organismal reproductive process (GO:0048609)4.60405873
38meiotic nuclear division (GO:0007126)4.60089200
39regulation of microtubule-based movement (GO:0060632)4.37399300
40behavioral response to nicotine (GO:0035095)4.30830736
41indolalkylamine metabolic process (GO:0006586)4.17372010
42indole-containing compound catabolic process (GO:0042436)4.16029440
43indolalkylamine catabolic process (GO:0046218)4.16029440
44tryptophan catabolic process (GO:0006569)4.16029440
45regulation of meiosis I (GO:0060631)4.13227345
46left/right pattern formation (GO:0060972)4.06687100
47glycerol ether metabolic process (GO:0006662)4.01092885
48meiosis I (GO:0007127)4.00491441
49seminiferous tubule development (GO:0072520)3.94309642
50kynurenine metabolic process (GO:0070189)3.93860073
51meiotic cell cycle (GO:0051321)3.90303741
52cellular ketone body metabolic process (GO:0046950)3.88626307
53axoneme assembly (GO:0035082)3.83694455
54single strand break repair (GO:0000012)3.81786980
55protein K11-linked deubiquitination (GO:0035871)3.81754688
56chromosome condensation (GO:0030261)3.80230355
57ether metabolic process (GO:0018904)3.73535002
58tryptophan metabolic process (GO:0006568)3.67093436
59L-fucose catabolic process (GO:0042355)3.66698805
60fucose catabolic process (GO:0019317)3.66698805
61L-fucose metabolic process (GO:0042354)3.66698805
62protein polyglutamylation (GO:0018095)3.66185252
63multicellular organismal development (GO:0007275)3.61868422
64DNA packaging (GO:0006323)3.58817714
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.56648071
66detection of light stimulus involved in visual perception (GO:0050908)3.56191132
67detection of light stimulus involved in sensory perception (GO:0050962)3.56191132
68sexual reproduction (GO:0019953)3.55108858
69microtubule polymerization or depolymerization (GO:0031109)3.54421909
70regulation of hippo signaling (GO:0035330)3.54090078
71protein localization to cilium (GO:0061512)3.47658971
72water-soluble vitamin biosynthetic process (GO:0042364)3.46198973
73ketone body metabolic process (GO:1902224)3.46139033
74genitalia morphogenesis (GO:0035112)3.45899191
75signal peptide processing (GO:0006465)3.40151708
76reflex (GO:0060004)3.32544626
77intraciliary transport (GO:0042073)3.31976885
78axon ensheathment in central nervous system (GO:0032291)3.31877989
79central nervous system myelination (GO:0022010)3.31877989
80indole-containing compound metabolic process (GO:0042430)3.27569419
81sulfation (GO:0051923)3.25447344
82photoreceptor cell maintenance (GO:0045494)3.18571418
83photoreceptor cell differentiation (GO:0046530)3.11411569
84eye photoreceptor cell differentiation (GO:0001754)3.11411569
85serotonin metabolic process (GO:0042428)3.11196592
86negative regulation of cytosolic calcium ion concentration (GO:0051481)3.11040264
87protein refolding (GO:0042026)3.10711927
88cilium organization (GO:0044782)3.10671971
89nucleoside diphosphate phosphorylation (GO:0006165)3.01512500
90cilium morphogenesis (GO:0060271)3.01496726
91protein complex biogenesis (GO:0070271)3.00677351
92regulation of gene silencing by RNA (GO:0060966)3.00037835
93regulation of posttranscriptional gene silencing (GO:0060147)3.00037835
94regulation of gene silencing by miRNA (GO:0060964)3.00037835
95monoubiquitinated protein deubiquitination (GO:0035520)2.98789617
96cilium assembly (GO:0042384)2.97499014
97chaperone-mediated protein complex assembly (GO:0051131)2.95013151
98cellular component assembly involved in morphogenesis (GO:0010927)2.94572657
99primary amino compound metabolic process (GO:1901160)2.93315394
100regulation of spindle checkpoint (GO:0090231)2.91893101
101snRNA transcription (GO:0009301)2.91619116
102DNA deamination (GO:0045006)2.89270074
103positive regulation of meiosis (GO:0045836)2.86241254
104meiotic cell cycle process (GO:1903046)2.86191122
105respiratory chain complex IV assembly (GO:0008535)2.85832837
106gene silencing by RNA (GO:0031047)2.84269394
107microtubule-based movement (GO:0007018)2.84235743
108mitochondrial respiratory chain complex I assembly (GO:0032981)2.83838906
109NADH dehydrogenase complex assembly (GO:0010257)2.83838906
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.83838906
111neuronal action potential (GO:0019228)2.82836402
112NAD biosynthetic process (GO:0009435)2.80694261
113behavioral response to ethanol (GO:0048149)2.80559878
114GTP biosynthetic process (GO:0006183)2.79687152
115positive regulation of meiotic cell cycle (GO:0051446)2.79517087
116positive regulation of oligodendrocyte differentiation (GO:0048714)2.78699272
117mitochondrial respiratory chain complex assembly (GO:0033108)2.76221757
118cellular biogenic amine catabolic process (GO:0042402)2.75751725
119amine catabolic process (GO:0009310)2.75751725
120regulation of cytokine production involved in inflammatory response (GO:1900015)2.75507029
121establishment of protein localization to Golgi (GO:0072600)2.74818710
122cellular response to ATP (GO:0071318)2.74671970
123thyroid hormone metabolic process (GO:0042403)2.74005602
1243-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.72595241
125purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.72595241
126negative regulation of systemic arterial blood pressure (GO:0003085)2.72521043
127synapsis (GO:0007129)2.71698862
128cytochrome complex assembly (GO:0017004)2.71285664
129preassembly of GPI anchor in ER membrane (GO:0016254)2.70364638
130centriole replication (GO:0007099)2.67305859
131L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65357438
132double-strand break repair via homologous recombination (GO:0000724)2.64375827
133recombinational repair (GO:0000725)2.63599985
134flavonoid metabolic process (GO:0009812)2.63566515
135carnitine transport (GO:0015879)2.63519345
136amino-acid betaine transport (GO:0015838)2.63519345
137cornea development in camera-type eye (GO:0061303)2.59114053
138gamma-aminobutyric acid transport (GO:0015812)2.58201494
139neural tube formation (GO:0001841)2.57704157
140auditory receptor cell stereocilium organization (GO:0060088)2.57645812
141proline transport (GO:0015824)2.57039899
142nucleoside diphosphate catabolic process (GO:0009134)2.56836970
143response to pheromone (GO:0019236)2.56723296
144negative regulation of mast cell activation (GO:0033004)2.56377160
145spinal cord motor neuron differentiation (GO:0021522)2.55937521
146regulation of action potential (GO:0098900)2.55920652
147benzene-containing compound metabolic process (GO:0042537)2.55327805
148aromatic amino acid family catabolic process (GO:0009074)2.54924938
149carnitine transmembrane transport (GO:1902603)2.54003055
150alditol metabolic process (GO:0019400)2.53356455
151mannosylation (GO:0097502)2.52754710
152positive regulation of macrophage activation (GO:0043032)2.51784540
153regulation of acrosome reaction (GO:0060046)2.49489503
154kidney morphogenesis (GO:0060993)2.49241286
155peptidyl-glutamic acid modification (GO:0018200)2.46603061
156replication fork processing (GO:0031297)2.46548003
157regulation of mesoderm development (GO:2000380)2.46420803
158nucleus organization (GO:0006997)2.45451856
159reciprocal DNA recombination (GO:0035825)2.44454123
160reciprocal meiotic recombination (GO:0007131)2.44454123
161righting reflex (GO:0060013)2.43941947
162centriole assembly (GO:0098534)2.43935775
163aromatic amino acid family metabolic process (GO:0009072)2.43796714
164regulation of glucokinase activity (GO:0033131)2.43675277
165regulation of hexokinase activity (GO:1903299)2.43675277
166replicative senescence (GO:0090399)2.42551351
167sequestering of actin monomers (GO:0042989)2.42380922
168photoreceptor cell development (GO:0042461)2.41943009
169G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.40723647
170retinal cone cell development (GO:0046549)2.39598178
171peristalsis (GO:0030432)2.39184504
172UTP biosynthetic process (GO:0006228)2.39093380
173regulation of neurotransmitter uptake (GO:0051580)2.38683929
174prostate gland growth (GO:0060736)2.37926777
175prenylation (GO:0097354)2.37784666
176protein prenylation (GO:0018342)2.37784666
177phosphatidylinositol acyl-chain remodeling (GO:0036149)2.37241582
178regulation of cilium assembly (GO:1902017)2.36550007
179oxidative demethylation (GO:0070989)2.36233687
180fusion of sperm to egg plasma membrane (GO:0007342)12.3978509
181sperm motility (GO:0030317)12.3707646
182cell wall macromolecule catabolic process (GO:0016998)11.5675506
183cell wall macromolecule metabolic process (GO:0044036)11.5675506
184acrosome reaction (GO:0007340)11.1925278
185sperm-egg recognition (GO:0035036)10.5308513
186multicellular organism reproduction (GO:0032504)10.3986520
187acrosome assembly (GO:0001675)10.3366254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.97032895
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.14887040
3EZH2_22144423_ChIP-Seq_EOC_Human4.11011717
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.58680238
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.51925661
6GBX2_23144817_ChIP-Seq_PC3_Human3.43440451
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.13333267
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.89664523
9IGF1R_20145208_ChIP-Seq_DFB_Human2.47383280
10VDR_22108803_ChIP-Seq_LS180_Human2.43193698
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.42116993
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.29266697
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09685816
14EWS_26573619_Chip-Seq_HEK293_Human2.05035287
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01319794
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.00224452
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.99364220
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97696285
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95373485
20P300_19829295_ChIP-Seq_ESCs_Human1.94989978
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93375668
22MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.89328842
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85821821
24KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.80508652
25STAT3_23295773_ChIP-Seq_U87_Human1.77367054
26SMAD4_21799915_ChIP-Seq_A2780_Human1.72250193
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.67518923
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65776647
29TAL1_26923725_Chip-Seq_HPCs_Mouse1.65450358
30BCAT_22108803_ChIP-Seq_LS180_Human1.65047803
31* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.64355697
32* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64152695
33TCF4_23295773_ChIP-Seq_U87_Human1.60397077
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60252517
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.59142975
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57934105
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57697700
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56630069
39STAT1_17558387_ChIP-Seq_HELA_Human1.55349124
40ZNF274_21170338_ChIP-Seq_K562_Hela1.54336728
41KDM2B_26808549_Chip-Seq_REH_Human1.53514016
42NR3C1_21868756_ChIP-Seq_MCF10A_Human1.53158783
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52591775
44TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52491398
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52398088
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49195604
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48507786
48* AR_25329375_ChIP-Seq_VCAP_Human1.48300333
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45951988
50KAP1_22055183_ChIP-Seq_ESCs_Mouse1.45916299
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44159911
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42828222
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.38870698
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.38083761
55ELK4_26923725_Chip-Seq_MESODERM_Mouse1.37537726
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.37472286
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37084720
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36019564
59GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.33849843
60TCF4_22108803_ChIP-Seq_LS180_Human1.32770678
61CBP_20019798_ChIP-Seq_JUKART_Human1.32465895
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32465895
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32194077
64TP53_22573176_ChIP-Seq_HFKS_Human1.32141840
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31218730
66IRF1_19129219_ChIP-ChIP_H3396_Human1.30278435
67ER_23166858_ChIP-Seq_MCF-7_Human1.29755609
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.28851804
69RNF2_27304074_Chip-Seq_NSC_Mouse1.28504942
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28271258
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.26967985
72* FOXA1_25329375_ChIP-Seq_VCAP_Human1.26586643
73* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26586643
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.25754168
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25691880
76NANOG_19829295_ChIP-Seq_ESCs_Human1.25640485
77SOX2_19829295_ChIP-Seq_ESCs_Human1.25640485
78AHR_22903824_ChIP-Seq_MCF-7_Human1.25589663
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25492551
80RUNX2_22187159_ChIP-Seq_PCA_Human1.24884102
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.24676693
82* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24441132
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24299020
84TAF15_26573619_Chip-Seq_HEK293_Human1.21990669
85P53_22387025_ChIP-Seq_ESCs_Mouse1.21886449
86SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21155611
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20512091
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20512091
89WDR5_24793694_ChIP-Seq_LNCAP_Human1.19851909
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.18809478
91PRDM14_20953172_ChIP-Seq_ESCs_Human1.17556363
92P53_21459846_ChIP-Seq_SAOS-2_Human1.17535664
93CDX2_22108803_ChIP-Seq_LS180_Human1.17006768
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16870404
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.16802931
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16233273
97GF1_26923725_Chip-Seq_HPCs_Mouse1.16005867
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14290577
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14046735
100MYC_18940864_ChIP-ChIP_HL60_Human1.13921079
101GATA3_21867929_ChIP-Seq_CD8_Mouse1.13683764
102AR_21572438_ChIP-Seq_LNCaP_Human1.13578152
103TP53_16413492_ChIP-PET_HCT116_Human1.13289289
104EP300_21415370_ChIP-Seq_HL-1_Mouse1.11751196
105REST_21632747_ChIP-Seq_MESCs_Mouse1.11602207
106P300_18555785_Chip-Seq_ESCs_Mouse1.10822212
107KLF4_18555785_Chip-Seq_ESCs_Mouse1.10467467
108* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10109749
109* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09698600
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09453233
111OCT4_18555785_Chip-Seq_ESCs_Mouse1.09274880
112FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09210770
113NCOR_22424771_ChIP-Seq_293T_Human1.09131529
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.08534880
115CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08334189
116LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.07863666
117RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07578062
118SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07086487
119CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06852345
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.06667644
121GATA3_21878914_ChIP-Seq_MCF-7_Human1.06574005
122* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06491559
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06080628
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05976217
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05772077
126ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05548275
127GF1B_26923725_Chip-Seq_HPCs_Mouse1.04717071
128FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03913448
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03624044
130GATA3_21867929_ChIP-Seq_TH1_Mouse1.03469583
131FUS_26573619_Chip-Seq_HEK293_Human1.03299509
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00431533
133HOXB7_26014856_ChIP-Seq_BT474_Human1.00315491
134RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00285722
135DROSHA_22980978_ChIP-Seq_HELA_Human1.00129589
136SOX2_18555785_Chip-Seq_ESCs_Mouse0.99923750
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.99881903
138ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99416562
139E2F1_18555785_Chip-Seq_ESCs_Mouse0.99012764
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98495153
141* AR_20517297_ChIP-Seq_VCAP_Human0.97759473
142PU1_27457419_Chip-Seq_LIVER_Mouse0.97434253
143SOX9_26525672_Chip-Seq_HEART_Mouse0.97423359
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97190463
145* ESET_19884257_ChIP-Seq_ESCs_Mouse0.97155494
146ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95907553
147FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95077008
148SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93374227
149* SMAD4_21741376_ChIP-Seq_EPCs_Human0.93196236
150NMYC_18555785_Chip-Seq_ESCs_Mouse0.92592631
151SMAD1_18555785_Chip-Seq_ESCs_Mouse0.92375349
152RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91847382
153EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91520068
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91147405
155CTCF_18555785_Chip-Seq_ESCs_Mouse0.89351180
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.88019006
157CTCF_20526341_ChIP-Seq_ESCs_Human0.87854909
158SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86616723
159POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86188943
160EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85902674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.51918328
2MP0001929_abnormal_gametogenesis5.25258992
3MP0008877_abnormal_DNA_methylation4.06958696
4MP0002210_abnormal_sex_determination3.50972788
5MP0002161_abnormal_fertility/fecundity3.05707841
6MP0001145_abnormal_male_reproductive2.95418020
7MP0000569_abnormal_digit_pigmentation2.75824375
8MP0000653_abnormal_sex_gland2.65989717
9MP0001968_abnormal_touch/_nociception2.33493872
10MP0002653_abnormal_ependyma_morphology2.30822275
11MP0002837_dystrophic_cardiac_calcinosis2.17837895
12MP0000383_abnormal_hair_follicle2.05374677
13MP0000427_abnormal_hair_cycle2.03621947
14MP0005410_abnormal_fertilization14.4840909
15MP0002876_abnormal_thyroid_physiology1.98799749
16MP0008872_abnormal_physiological_respon1.94438667
17MP0001485_abnormal_pinna_reflex1.92958006
18MP0009745_abnormal_behavioral_response1.87049570
19MP0001501_abnormal_sleep_pattern1.84314865
20MP0004233_abnormal_muscle_weight1.79620863
21MP0006292_abnormal_olfactory_placode1.79023240
22MP0005645_abnormal_hypothalamus_physiol1.75180077
23MP0005174_abnormal_tail_pigmentation1.72301801
24MP0008057_abnormal_DNA_replication1.71886875
25MP0003950_abnormal_plasma_membrane1.70050190
26MP0000631_abnormal_neuroendocrine_gland1.66262579
27MP0010386_abnormal_urinary_bladder1.65778535
28MP0003011_delayed_dark_adaptation1.59903495
29MP0005623_abnormal_meninges_morphology1.58905152
30MP0003787_abnormal_imprinting1.55274346
31MP0002282_abnormal_trachea_morphology1.54267682
32MP0002138_abnormal_hepatobiliary_system1.52451868
33MP0002735_abnormal_chemical_nociception1.51294384
34MP0000920_abnormal_myelination1.47751871
35MP0010678_abnormal_skin_adnexa1.47491515
36MP0002638_abnormal_pupillary_reflex1.44397197
37MP0005670_abnormal_white_adipose1.43624236
38MP0000516_abnormal_urinary_system1.42391215
39MP0005367_renal/urinary_system_phenotyp1.42391215
40MP0001958_emphysema1.41945736
41MP0002938_white_spotting1.38892654
42MP0006054_spinal_hemorrhage1.37539284
43MP0005451_abnormal_body_composition1.36683663
44MP0002928_abnormal_bile_duct1.36015532
45MP0001986_abnormal_taste_sensitivity1.34778423
46MP0003646_muscle_fatigue1.34616854
47MP0002064_seizures1.33961517
48MP0008875_abnormal_xenobiotic_pharmacok1.32508695
49MP0003718_maternal_effect1.32095990
50MP0001486_abnormal_startle_reflex1.29981968
51MP0005379_endocrine/exocrine_gland_phen1.29445066
52MP0002160_abnormal_reproductive_system1.28751659
53MP0002572_abnormal_emotion/affect_behav1.26931071
54MP0004142_abnormal_muscle_tone1.25898201
55MP0004134_abnormal_chest_morphology1.23120321
56MP0002733_abnormal_thermal_nociception1.22728944
57MP0001970_abnormal_pain_threshold1.21674109
58MP0005503_abnormal_tendon_morphology1.21649338
59MP0003119_abnormal_digestive_system1.20516060
60MP0002909_abnormal_adrenal_gland1.19202799
61MP0006276_abnormal_autonomic_nervous1.18816069
62MP0002163_abnormal_gland_morphology1.15998002
63MP0004133_heterotaxia1.15811127
64MP0004147_increased_porphyrin_level1.15342522
65MP0002693_abnormal_pancreas_physiology1.12826612
66MP0001542_abnormal_bone_strength1.11939512
67MP0003329_amyloid_beta_deposits1.11405006
68MP0002557_abnormal_social/conspecific_i1.09330105
69MP0000462_abnormal_digestive_system1.08937234
70MP0000013_abnormal_adipose_tissue1.06755737
71MP0002102_abnormal_ear_morphology1.06288535
72MP0009250_abnormal_appendicular_skeleto1.05102171
73MP0005083_abnormal_biliary_tract1.03039074
74MP0003635_abnormal_synaptic_transmissio1.02608519
75MP0004924_abnormal_behavior0.98979927
76MP0005386_behavior/neurological_phenoty0.98979927
77MP0000538_abnormal_urinary_bladder0.98280712
78MP0005085_abnormal_gallbladder_physiolo0.98061972
79MP0001944_abnormal_pancreas_morphology0.97885098
80MP0002295_abnormal_pulmonary_circulatio0.97784874
81MP0000230_abnormal_systemic_arterial0.95579279
82MP0001299_abnormal_eye_distance/0.94805201
83MP0000372_irregular_coat_pigmentation0.92301451
84MP0001765_abnormal_ion_homeostasis0.90161448
85MP0002067_abnormal_sensory_capabilities0.89936256
86MP0002234_abnormal_pharynx_morphology0.88849897
87MP0005195_abnormal_posterior_eye0.88831537
88MP0005220_abnormal_exocrine_pancreas0.87586013
89MP0001664_abnormal_digestion0.87532189
90MP0004270_analgesia0.87261972
91MP0003115_abnormal_respiratory_system0.87077902
92MP0002063_abnormal_learning/memory/cond0.86980135
93MP0001661_extended_life_span0.86777026
94MP0003252_abnormal_bile_duct0.86288740
95MP0005084_abnormal_gallbladder_morpholo0.85674250
96MP0000604_amyloidosis0.84929355
97MP0001756_abnormal_urination0.84476962
98MP0005332_abnormal_amino_acid0.84013687
99MP0003136_yellow_coat_color0.83506636
100MP0004043_abnormal_pH_regulation0.82531301
101MP0002254_reproductive_system_inflammat0.81105400
102MP0000049_abnormal_middle_ear0.80436351
103MP0001764_abnormal_homeostasis0.79726377
104MP0003045_fibrosis0.79630315
105MP0003283_abnormal_digestive_organ0.79603139
106MP0001919_abnormal_reproductive_system0.78151933
107MP0002734_abnormal_mechanical_nocicepti0.77819140
108MP0008438_abnormal_cutaneous_collagen0.73715787
109MP0005647_abnormal_sex_gland0.72193001
110MP0005377_hearing/vestibular/ear_phenot0.72020538
111MP0003878_abnormal_ear_physiology0.72020538
112MP0003279_aneurysm0.71357091
113MP0003195_calcinosis0.66644091
114MP0001177_atelectasis0.63946755
115MP0005551_abnormal_eye_electrophysiolog0.62856611
116MP0005389_reproductive_system_phenotype0.62352200
117MP0008995_early_reproductive_senescence0.62139930
118MP0009780_abnormal_chondrocyte_physiolo0.60272247
119MP0003699_abnormal_female_reproductive0.60179517
120MP0010368_abnormal_lymphatic_system0.58644752
121MP0004885_abnormal_endolymph0.56203562
122MP0003690_abnormal_glial_cell0.55557640
123MP0002133_abnormal_respiratory_system0.55068432
124MP0005388_respiratory_system_phenotype0.55068432
125MP0005253_abnormal_eye_physiology0.55057218
126MP0004036_abnormal_muscle_relaxation0.54661363
127MP0001529_abnormal_vocalization0.53013403
128MP0003937_abnormal_limbs/digits/tail_de0.52629786
129MP0002177_abnormal_outer_ear0.52326708
130MP0004085_abnormal_heartbeat0.52245451
131MP0003880_abnormal_central_pattern0.51857624
132MP0005508_abnormal_skeleton_morphology0.50313416
133MP0002736_abnormal_nociception_after0.50269612
134MP0005646_abnormal_pituitary_gland0.50202430
135MP0005257_abnormal_intraocular_pressure0.49825705
136MP0002115_abnormal_skeleton_extremities0.49776028
137MP0009046_muscle_twitch0.49401081
138MP0001849_ear_inflammation0.49121291
139MP0001727_abnormal_embryo_implantation0.48709490
140MP0003634_abnormal_glial_cell0.48606251
141MP0005408_hypopigmentation0.47739147
142MP0004742_abnormal_vestibular_system0.45935105
143MP0002249_abnormal_larynx_morphology0.45006356
144MP0001324_abnormal_eye_pigmentation0.43886321
145MP0002108_abnormal_muscle_morphology0.42098286
146MP0001984_abnormal_olfaction0.41466428
147MP0002116_abnormal_craniofacial_bone0.41404716
148MP0002272_abnormal_nervous_system0.41374145
149MP0000163_abnormal_cartilage_morphology0.41220823
150MP0005275_abnormal_skin_tensile0.41011341
151MP0001119_abnormal_female_reproductive0.41005836
152MP0003632_abnormal_nervous_system0.38985905
153MP0001905_abnormal_dopamine_level0.38780826
154MP0005636_abnormal_mineral_homeostasis0.38269939
155MP0000432_abnormal_head_morphology0.37858212
156MP0003942_abnormal_urinary_system0.37287221
157MP0003631_nervous_system_phenotype0.36846458
158MP0005171_absent_coat_pigmentation0.36474129
159MP0006072_abnormal_retinal_apoptosis0.35814670
160MP0002229_neurodegeneration0.34342902
161MP0000762_abnormal_tongue_morphology0.34093235
162MP0004145_abnormal_muscle_electrophysio0.33776671
163MP0003786_premature_aging0.33429319
164MP0003633_abnormal_nervous_system0.33277444
165MP0003938_abnormal_ear_development0.32782608
166MP0005391_vision/eye_phenotype0.32539846
167MP0002896_abnormal_bone_mineralization0.32456231
168MP0000778_abnormal_nervous_system0.32412855
169MP0002109_abnormal_limb_morphology0.31947413

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.92732331
2Abnormal respiratory motile cilium morphology (HP:0005938)8.13064517
3Abnormal respiratory epithelium morphology (HP:0012253)8.13064517
4Rhinitis (HP:0012384)7.36642690
5Chronic bronchitis (HP:0004469)7.25230406
6Abnormal ciliary motility (HP:0012262)6.92971351
7Infertility (HP:0000789)5.70741727
8Nasal polyposis (HP:0100582)4.96244559
9Pancreatic cysts (HP:0001737)4.54142392
10Pancreatic fibrosis (HP:0100732)4.10403826
11Bronchitis (HP:0012387)4.08579960
12Nephronophthisis (HP:0000090)4.07125705
13Bronchiectasis (HP:0002110)4.06797297
14True hermaphroditism (HP:0010459)3.97821144
15Abnormality of the nasal mucosa (HP:0000433)3.91839348
16Male infertility (HP:0003251)3.58831766
17Congenital stationary night blindness (HP:0007642)3.45727286
18Genetic anticipation (HP:0003743)3.29028555
19Hyperventilation (HP:0002883)3.22720745
20Gaze-evoked nystagmus (HP:0000640)3.15223793
21Medial flaring of the eyebrow (HP:0010747)3.12701921
22Abnormality of the renal medulla (HP:0100957)3.05805830
23Progressive cerebellar ataxia (HP:0002073)2.98256654
24Cystic liver disease (HP:0006706)2.97109600
25Tubulointerstitial nephritis (HP:0001970)2.93630352
26Bell-shaped thorax (HP:0001591)2.92200648
27Recurrent otitis media (HP:0000403)2.91212953
28Tubular atrophy (HP:0000092)2.87803494
29Pendular nystagmus (HP:0012043)2.85601962
30Abnormal spermatogenesis (HP:0008669)2.80522886
31Large for gestational age (HP:0001520)2.76089514
32Abolished electroretinogram (ERG) (HP:0000550)2.71814049
33Recurrent sinusitis (HP:0011108)2.63350568
34Chronic hepatic failure (HP:0100626)2.62017075
35Furrowed tongue (HP:0000221)2.60881413
36Congenital sensorineural hearing impairment (HP:0008527)2.58747711
37Sclerocornea (HP:0000647)2.49228796
38Abnormality of dentin (HP:0010299)2.48771571
39Molar tooth sign on MRI (HP:0002419)2.46912107
40Abnormality of midbrain morphology (HP:0002418)2.46912107
41Ketoacidosis (HP:0001993)2.42070823
42Keratoconus (HP:0000563)2.39269296
43Increased corneal curvature (HP:0100692)2.39269296
44Chorioretinal atrophy (HP:0000533)2.33923576
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.29325192
46Tubulointerstitial abnormality (HP:0001969)2.26815628
47Absent frontal sinuses (HP:0002688)2.25832656
48Decreased circulating renin level (HP:0003351)2.25004258
49Neurofibrillary tangles (HP:0002185)2.23697988
50Severe muscular hypotonia (HP:0006829)2.22660775
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22103895
52Abnormality of alanine metabolism (HP:0010916)2.22103895
53Hyperalaninemia (HP:0003348)2.22103895
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.21390319
55Protruding tongue (HP:0010808)2.16971008
56Gait imbalance (HP:0002141)2.14976746
57Congenital primary aphakia (HP:0007707)2.14736748
58Cerebellar dysplasia (HP:0007033)2.12325818
59Inability to walk (HP:0002540)2.12235436
60Clumsiness (HP:0002312)2.12006895
61Stage 5 chronic kidney disease (HP:0003774)2.08164993
62Cholecystitis (HP:0001082)2.07072195
63Abnormal gallbladder physiology (HP:0012438)2.07072195
64Febrile seizures (HP:0002373)2.06916515
65Male pseudohermaphroditism (HP:0000037)2.06442837
66Hypothermia (HP:0002045)2.05938585
67Broad-based gait (HP:0002136)2.05548585
68Fibular hypoplasia (HP:0003038)2.05320478
69Progressive inability to walk (HP:0002505)2.03805956
70Abnormality of the renal collecting system (HP:0004742)2.02229813
71Fair hair (HP:0002286)2.01603621
72Abnormal rod and cone electroretinograms (HP:0008323)2.01215507
73Azoospermia (HP:0000027)2.01212132
74Ketosis (HP:0001946)2.00408299
75Short nail (HP:0001799)2.00240458
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2321510
77Absent/shortened dynein arms (HP:0200106)11.9285186
78Dynein arm defect of respiratory motile cilia (HP:0012255)11.9285186
79Aplasia/Hypoplasia of the lens (HP:0008063)1.99351488
80Short 1st metacarpal (HP:0010034)1.98563460
81Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.98563460
82Recurrent bronchitis (HP:0002837)1.97479664
83Ectopic kidney (HP:0000086)1.96906275
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96106039
85Polydipsia (HP:0001959)1.95585756
86Abnormal drinking behavior (HP:0030082)1.95585756
87Congenital, generalized hypertrichosis (HP:0004540)1.94017132
88Anencephaly (HP:0002323)1.92815049
89Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.91025811
90Gonadotropin excess (HP:0000837)1.90917871
91Hypoplasia of the pons (HP:0012110)1.90004873
92Vaginal atresia (HP:0000148)1.89254829
93Hemiparesis (HP:0001269)1.87033585
94Absent thumb (HP:0009777)1.86495390
95Genital tract atresia (HP:0001827)1.85607607
96Polyuria (HP:0000103)1.83322774
97Methylmalonic acidemia (HP:0002912)1.83257112
98Duplicated collecting system (HP:0000081)1.82343952
99Aplasia/Hypoplasia of the patella (HP:0006498)1.81866053
100Tachypnea (HP:0002789)1.81582465
101Abnormality of the pons (HP:0007361)1.81409006
102Small hand (HP:0200055)1.80481878
103Abnormality of the renal cortex (HP:0011035)1.80111653
104Absent speech (HP:0001344)1.79894833
105Renal cortical cysts (HP:0000803)1.79692115
106Preaxial hand polydactyly (HP:0001177)1.77994762
107Patellar aplasia (HP:0006443)1.77716989
108Increased CSF lactate (HP:0002490)1.77287063
109Methylmalonic aciduria (HP:0012120)1.75865195
110Retinal dysplasia (HP:0007973)1.74988892
111Postaxial foot polydactyly (HP:0001830)1.74952648
112Neoplasm of the adrenal cortex (HP:0100641)1.74458201
113Concave nail (HP:0001598)1.74180902
114Bile duct proliferation (HP:0001408)1.73573134
115Abnormal biliary tract physiology (HP:0012439)1.73573134
116Short hallux (HP:0010109)1.73257567
117Nephrogenic diabetes insipidus (HP:0009806)1.71595132
118Renovascular hypertension (HP:0100817)1.70241616
119Abnormality of the nasal septum (HP:0000419)1.69434495
120Abnormality of DNA repair (HP:0003254)1.69239795
121Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68364313
122Abnormality of macular pigmentation (HP:0008002)1.68247602
123Overriding aorta (HP:0002623)1.67759568
124Abnormality of the 1st metacarpal (HP:0010009)1.67541504
125Birth length less than 3rd percentile (HP:0003561)1.67371925
126Retinitis pigmentosa (HP:0000510)1.67220836
127Degeneration of the lateral corticospinal tracts (HP:0002314)1.66579890
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66579890
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65179082
130Absent epiphyses (HP:0010577)1.65179082
131Short femoral neck (HP:0100864)1.64907389
132Abnormality of permanent molar morphology (HP:0011071)1.64570650
133Abnormality of the dental root (HP:0006486)1.64570650
134Taurodontia (HP:0000679)1.64570650
135Poor coordination (HP:0002370)1.63269963
136Pulmonary artery stenosis (HP:0004415)1.61347658
137Tubulointerstitial fibrosis (HP:0005576)1.60544745
138Postaxial hand polydactyly (HP:0001162)1.59595986
139Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59324054
140Abnormality of molar morphology (HP:0011070)1.59120408
141Abnormality of molar (HP:0011077)1.59120408
142Impulsivity (HP:0100710)1.59027858
143Choroideremia (HP:0001139)1.58707848
144Decreased central vision (HP:0007663)1.56006144
145Abnormality of the dental pulp (HP:0006479)1.53559017
146Short ribs (HP:0000773)1.51444204
147Cerebral inclusion bodies (HP:0100314)1.49961089
148Abnormality of the frontal sinuses (HP:0002687)1.48384495
149Dyschromatopsia (HP:0007641)1.48224854
150Attenuation of retinal blood vessels (HP:0007843)1.47506575
151Abnormality of renal excretion (HP:0011036)1.47205031
152Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.47132218
153Broad distal phalanx of finger (HP:0009836)1.46024481
154Congenital hepatic fibrosis (HP:0002612)1.44488496
155Flattened epiphyses (HP:0003071)1.44214436
156Sensory axonal neuropathy (HP:0003390)1.44099480
157Spastic tetraparesis (HP:0001285)1.42940823
158Microglossia (HP:0000171)1.42444855
159Aplasia/Hypoplasia of the fibula (HP:0006492)1.42384920
160Bony spicule pigmentary retinopathy (HP:0007737)1.40462090
161Heterotopia (HP:0002282)1.39536885
162Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.37082008
163Facial cleft (HP:0002006)1.36195170
164Hypodontia (HP:0000668)1.35422143
165Oculomotor apraxia (HP:0000657)1.33091796
166Bladder diverticulum (HP:0000015)1.30870931
167Renal dysplasia (HP:0000110)1.30385218
168Ridged nail (HP:0001807)1.28488176
169Adrenal hypoplasia (HP:0000835)1.27836543
170Hemorrhage of the eye (HP:0011885)1.26835262
171Irregular epiphyses (HP:0010582)1.24971968
172Type II lissencephaly (HP:0007260)1.24936122
173Premature rupture of membranes (HP:0001788)1.24844417
174Peripheral hypomyelination (HP:0007182)1.24224135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.70631385
2PDK47.67171343
3PDK37.67171343
4PDK25.03304669
5TESK14.97594074
6PRKD34.66145427
7STK393.88223510
8ICK3.71477781
9ADRBK22.91498064
10WNK42.86718948
11GRK12.58003506
12ZAK2.47313507
13PTK2B2.21818467
14WNK32.07583723
15MAP4K22.00317339
16CASK1.80195499
17MAPK151.78808692
18PNCK1.71536654
19TAF11.52625093
20WNK11.50974406
21TLK11.40145831
22NTRK31.38472716
23MST41.37205515
24DAPK21.30832189
25OXSR11.29575903
26TAOK31.27934011
27MKNK21.18942728
28ADRBK11.14981324
29AKT31.13267054
30MAPKAPK51.11593047
31DYRK1B1.07256007
32STK381.06138822
33NEK20.99448686
34TESK20.98774748
35MAP2K60.97684555
36MAP3K20.91774206
37CSNK1G10.90599582
38PINK10.89841437
39TYRO30.89812430
40VRK20.89313327
41BRSK20.88729552
42PDK10.88027222
43IRAK10.86934846
44TRIM280.86326370
45VRK10.85744409
46STK30.83436641
47MUSK0.82365653
48EPHB10.82326136
49FER0.81855844
50CSNK1A1L0.80013715
51BCR0.79754669
52PHKG10.76684223
53PHKG20.76684223
54PLK20.76176245
55CSNK1G30.74639769
56BMX0.74451444
57MAPKAPK30.74384229
58CSNK1G20.74040121
59PRKCI0.72841391
60PBK0.70121861
61TGFBR10.68111948
62MAP3K40.66525149
63MAP2K70.66009966
64PKN10.64675301
65NLK0.63938709
66DYRK30.61315397
67PIK3CG0.61165066
68NEK60.59022586
69PRKAA20.58907762
70NUAK10.58551194
71CHEK20.57590708
72PDPK10.57543963
73MAP2K10.56265417
74PRKAA10.55807948
75NTRK20.55562508
76SGK20.55371895
77PASK0.54834863
78BMPR1B0.54736112
79RPS6KA50.52290037
80GRK50.52030075
81ERBB40.51264583
82MELK0.48919432
83NME10.46190934
84IRAK20.45694333
85PRKCQ0.45681486
86PAK10.45627722
87ACVR1B0.45508979
88CAMKK20.45195101
89CSNK1A10.45016010
90PLK30.44456407
91MET0.44236591
92PAK60.44206455
93IKBKB0.43606089
94PIK3CA0.43127675
95CAMK10.42846468
96TRPM70.41242062
97TTK0.40365443
98RIPK40.39167518
99PLK10.38547793
100EIF2AK30.38497459
101TEC0.37663567
102TXK0.37086150
103CCNB10.36876581
104TIE10.36561153
105MARK10.36181776
106TNK20.35977976
107FLT30.35587045
108CDK190.35382050
109MARK20.34909747
110CHUK0.34442563
111ATR0.34348074
112CAMK2A0.33681504
113PLK40.33246856
114STK38L0.32803640
115PRKCG0.32720523
116EPHA40.32378734
117CAMK2D0.30011961
118DAPK10.29938691
119SGK2230.28744986
120SGK4940.28744986
121CHEK10.28640296
122CDK150.28419127
123ERBB30.28316596
124FGFR20.27686733
125CDK140.27661027
126LIMK10.27546219
127FGR0.25866440
128CDK180.25449981
129CAMK2B0.23332730
130DDR20.22472854
131MAPK130.22030718
132ATM0.21648654
133CDK11A0.21320862
134ROCK20.20341906
135CAMK1G0.20087513
136CSNK1D0.19433729
137PAK20.18762392
138TNIK0.18569667
139DYRK20.17205594
140LATS10.16482615
141PRKG10.15995381
142UHMK10.15319682
143DMPK0.14843050
144GSK3A0.14694563
145INSRR0.14142177
146CAMK2G0.13609541
147BRAF0.13383045
148WEE10.13110993
149MTOR0.12459533
150PRKD20.11416325
151CDK50.11267473
152PRKG20.11179476
153LMTK20.10768208
154NTRK10.10709933
155PRKACB0.10652569
156EEF2K0.08773463
157PRKCZ0.08648627
158PRKACA0.07540109
159GSK3B0.06683206
160PRKCE0.06549183
161STK110.06224609
162KSR20.05932082
163CDK30.05340260
164PAK30.05225894

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.67987029
2Linoleic acid metabolism_Homo sapiens_hsa005913.55391432
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.50553126
4Fatty acid biosynthesis_Homo sapiens_hsa000613.40539226
5Pyruvate metabolism_Homo sapiens_hsa006203.26435890
6Ether lipid metabolism_Homo sapiens_hsa005653.11169956
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.07679097
8Basal transcription factors_Homo sapiens_hsa030222.64453651
9Butanoate metabolism_Homo sapiens_hsa006502.53358132
10Phototransduction_Homo sapiens_hsa047442.48821420
11Propanoate metabolism_Homo sapiens_hsa006402.46513695
12Nicotine addiction_Homo sapiens_hsa050332.17837664
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.11101022
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.08773589
15Homologous recombination_Homo sapiens_hsa034402.02537034
16Tryptophan metabolism_Homo sapiens_hsa003802.02099221
17Steroid biosynthesis_Homo sapiens_hsa001002.01358964
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97388350
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97293131
20Glucagon signaling pathway_Homo sapiens_hsa049221.96904100
21Nitrogen metabolism_Homo sapiens_hsa009101.95358603
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95300356
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91352779
24Dorso-ventral axis formation_Homo sapiens_hsa043201.85211816
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76486436
26Protein export_Homo sapiens_hsa030601.74015748
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.72257047
28Huntingtons disease_Homo sapiens_hsa050161.65113983
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.63529828
30Glycerolipid metabolism_Homo sapiens_hsa005611.61369196
31Selenocompound metabolism_Homo sapiens_hsa004501.57377020
32Sulfur metabolism_Homo sapiens_hsa009201.56173426
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55273568
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53190026
35Fatty acid elongation_Homo sapiens_hsa000621.49654066
36Amphetamine addiction_Homo sapiens_hsa050311.46902659
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.43749409
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43422721
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.43332566
40Arachidonic acid metabolism_Homo sapiens_hsa005901.39134562
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.38258909
42Cardiac muscle contraction_Homo sapiens_hsa042601.32945030
43Oocyte meiosis_Homo sapiens_hsa041141.31336252
44Olfactory transduction_Homo sapiens_hsa047401.30376041
45PPAR signaling pathway_Homo sapiens_hsa033201.27940932
46SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27314063
47Fatty acid metabolism_Homo sapiens_hsa012121.25346823
48RNA polymerase_Homo sapiens_hsa030201.25074266
49Morphine addiction_Homo sapiens_hsa050321.23120611
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22978225
51Protein digestion and absorption_Homo sapiens_hsa049741.21270400
52Retinol metabolism_Homo sapiens_hsa008301.19800974
53Caffeine metabolism_Homo sapiens_hsa002321.15682726
54Mineral absorption_Homo sapiens_hsa049781.15209161
55Regulation of autophagy_Homo sapiens_hsa041401.11528085
56Sphingolipid metabolism_Homo sapiens_hsa006001.08883182
57Serotonergic synapse_Homo sapiens_hsa047261.07439963
58* Chemical carcinogenesis_Homo sapiens_hsa052041.06970816
59beta-Alanine metabolism_Homo sapiens_hsa004101.05903593
60One carbon pool by folate_Homo sapiens_hsa006701.04639257
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01777887
62Hedgehog signaling pathway_Homo sapiens_hsa043401.00319535
63Collecting duct acid secretion_Homo sapiens_hsa049660.98934438
64Purine metabolism_Homo sapiens_hsa002300.98848447
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98408961
66Fanconi anemia pathway_Homo sapiens_hsa034600.97785461
67Sulfur relay system_Homo sapiens_hsa041220.96913721
68Peroxisome_Homo sapiens_hsa041460.96149715
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93683919
70Renin secretion_Homo sapiens_hsa049240.93271259
71Circadian rhythm_Homo sapiens_hsa047100.89010174
72GABAergic synapse_Homo sapiens_hsa047270.88523909
73Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88392184
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83581179
75Fat digestion and absorption_Homo sapiens_hsa049750.83205669
76Oxidative phosphorylation_Homo sapiens_hsa001900.80338826
77* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79607946
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79136187
79Insulin secretion_Homo sapiens_hsa049110.79121647
80Vibrio cholerae infection_Homo sapiens_hsa051100.78666258
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78398362
82Fatty acid degradation_Homo sapiens_hsa000710.77746426
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76947487
84Non-homologous end-joining_Homo sapiens_hsa034500.76215072
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73393811
86Ovarian steroidogenesis_Homo sapiens_hsa049130.73130575
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72231128
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.72170462
89Calcium signaling pathway_Homo sapiens_hsa040200.71396512
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.70230691
91Rheumatoid arthritis_Homo sapiens_hsa053230.69904365
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.67417992
93Vitamin digestion and absorption_Homo sapiens_hsa049770.66348507
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63976443
95Circadian entrainment_Homo sapiens_hsa047130.63867181
96Long-term potentiation_Homo sapiens_hsa047200.58625569
97Glutamatergic synapse_Homo sapiens_hsa047240.57177655
98Long-term depression_Homo sapiens_hsa047300.57039324
99ECM-receptor interaction_Homo sapiens_hsa045120.55410934
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55347726
101Complement and coagulation cascades_Homo sapiens_hsa046100.54269963
102Lysine degradation_Homo sapiens_hsa003100.54231242
103Dopaminergic synapse_Homo sapiens_hsa047280.54202729
104Pentose phosphate pathway_Homo sapiens_hsa000300.53821573
105Alzheimers disease_Homo sapiens_hsa050100.53589659
106Metabolic pathways_Homo sapiens_hsa011000.53389048
107Estrogen signaling pathway_Homo sapiens_hsa049150.52688464
108Cocaine addiction_Homo sapiens_hsa050300.52187143
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51510223
110Inositol phosphate metabolism_Homo sapiens_hsa005620.51266394
111Malaria_Homo sapiens_hsa051440.50615260
112Taste transduction_Homo sapiens_hsa047420.48454775
113* Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47961499
114Thyroid hormone synthesis_Homo sapiens_hsa049180.47795900
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.47439126
116Type II diabetes mellitus_Homo sapiens_hsa049300.46205993
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44488251
118Alcoholism_Homo sapiens_hsa050340.43415324
119cAMP signaling pathway_Homo sapiens_hsa040240.42512056
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42408218
121Endocytosis_Homo sapiens_hsa041440.42370400
122Axon guidance_Homo sapiens_hsa043600.42247327
123Pyrimidine metabolism_Homo sapiens_hsa002400.41173227
124Systemic lupus erythematosus_Homo sapiens_hsa053220.39949697
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39664514
126Cholinergic synapse_Homo sapiens_hsa047250.36972125
127Ras signaling pathway_Homo sapiens_hsa040140.35369555
128* Glutathione metabolism_Homo sapiens_hsa004800.35086636
129Carbon metabolism_Homo sapiens_hsa012000.34369614
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34322119
131mRNA surveillance pathway_Homo sapiens_hsa030150.32546698
132Wnt signaling pathway_Homo sapiens_hsa043100.32529574
133Fructose and mannose metabolism_Homo sapiens_hsa000510.31859287
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31822506
135Parkinsons disease_Homo sapiens_hsa050120.30082939
136Gastric acid secretion_Homo sapiens_hsa049710.29684360
137Pancreatic secretion_Homo sapiens_hsa049720.29357298
138RNA degradation_Homo sapiens_hsa030180.29243201
139Basal cell carcinoma_Homo sapiens_hsa052170.28085441
140Histidine metabolism_Homo sapiens_hsa003400.27163478
141Salivary secretion_Homo sapiens_hsa049700.25081346
142ABC transporters_Homo sapiens_hsa020100.25066232
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.23398399
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22689105
145MAPK signaling pathway_Homo sapiens_hsa040100.21378228

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