GSTP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)9.89357492
2melanin metabolic process (GO:0006582)8.88831822
3secondary metabolite biosynthetic process (GO:0044550)8.65754399
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.30179902
5L-phenylalanine catabolic process (GO:0006559)7.30179902
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.79357123
7L-phenylalanine metabolic process (GO:0006558)6.79357123
8axon ensheathment in central nervous system (GO:0032291)6.37360885
9central nervous system myelination (GO:0022010)6.37360885
10fatty acid elongation (GO:0030497)6.35263842
11aromatic amino acid family catabolic process (GO:0009074)5.77571136
12proteasome assembly (GO:0043248)5.70516389
13bile acid biosynthetic process (GO:0006699)4.98405280
14glyoxylate metabolic process (GO:0046487)4.79415983
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.54533277
16pigment biosynthetic process (GO:0046148)4.49034423
17regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.47901920
18heme transport (GO:0015886)4.43443382
19indole-containing compound catabolic process (GO:0042436)4.42474605
20indolalkylamine catabolic process (GO:0046218)4.42474605
21tryptophan catabolic process (GO:0006569)4.42474605
22cullin deneddylation (GO:0010388)4.36022082
23cysteine metabolic process (GO:0006534)4.32609459
24coenzyme catabolic process (GO:0009109)4.31378813
25regulation of cellular amino acid metabolic process (GO:0006521)4.29831274
26aromatic amino acid family metabolic process (GO:0009072)4.26428536
27tyrosine metabolic process (GO:0006570)4.25570802
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.24985277
29kynurenine metabolic process (GO:0070189)4.21190600
30aldehyde catabolic process (GO:0046185)4.19687442
31melanosome organization (GO:0032438)4.16404855
32cofactor catabolic process (GO:0051187)4.15955156
33negative regulation of ligase activity (GO:0051352)4.13260100
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.13260100
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.12982435
36tryptophan metabolic process (GO:0006568)4.12374537
37establishment of protein localization to mitochondrial membrane (GO:0090151)4.11295773
38complement activation, alternative pathway (GO:0006957)4.07137221
39bile acid metabolic process (GO:0008206)4.07025908
40regulation of protein activation cascade (GO:2000257)4.05415883
41protein deneddylation (GO:0000338)4.04978050
42DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.03681152
43chaperone-mediated protein transport (GO:0072321)4.00903193
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.97767004
45intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.97767004
46signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.97393023
47signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.97393023
48signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.97393023
49very long-chain fatty acid metabolic process (GO:0000038)3.97195900
50DNA strand elongation involved in DNA replication (GO:0006271)3.94391534
51sulfur amino acid catabolic process (GO:0000098)3.92655041
52triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.92531231
53CENP-A containing nucleosome assembly (GO:0034080)3.90038568
54telomere maintenance via semi-conservative replication (GO:0032201)3.88663745
55regulation of fibrinolysis (GO:0051917)3.88403332
56negative regulation of fibrinolysis (GO:0051918)3.87755855
57pigment granule organization (GO:0048753)3.87615973
58chromatin remodeling at centromere (GO:0031055)3.87424546
59cholesterol biosynthetic process (GO:0006695)3.87146593
60regulation of complement activation (GO:0030449)3.85740271
61signal transduction involved in DNA integrity checkpoint (GO:0072401)3.84041207
62signal transduction involved in DNA damage checkpoint (GO:0072422)3.84041207
63respiratory electron transport chain (GO:0022904)3.78666271
64signal transduction involved in cell cycle checkpoint (GO:0072395)3.76238757
65pigment metabolic process (GO:0042440)3.73410569
66establishment of integrated proviral latency (GO:0075713)3.73291817
67long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.73046353
68fatty-acyl-CoA biosynthetic process (GO:0046949)3.71383382
69DNA strand elongation (GO:0022616)3.71290438
70alpha-linolenic acid metabolic process (GO:0036109)3.70015364
71electron transport chain (GO:0022900)3.69387935
72L-serine metabolic process (GO:0006563)3.66343911
73serine family amino acid biosynthetic process (GO:0009070)3.65782630
74high-density lipoprotein particle remodeling (GO:0034375)3.65264009
75myelination (GO:0042552)3.62893184
76axon ensheathment (GO:0008366)3.62715142
77ensheathment of neurons (GO:0007272)3.62715142
78removal of superoxide radicals (GO:0019430)3.61914886
79cellular response to superoxide (GO:0071451)3.61914886
80cellular response to oxygen radical (GO:0071450)3.61914886
81peptidyl-glutamic acid carboxylation (GO:0017187)3.60207099
82protein carboxylation (GO:0018214)3.60207099
83iron coordination entity transport (GO:1901678)3.59864684
84alpha-amino acid catabolic process (GO:1901606)3.59302740
85aspartate family amino acid catabolic process (GO:0009068)3.54277508
86fatty-acyl-CoA metabolic process (GO:0035337)3.53513320
87ethanol oxidation (GO:0006069)3.52473233
88urea metabolic process (GO:0019627)3.52136212
89urea cycle (GO:0000050)3.52136212
90regulation of triglyceride catabolic process (GO:0010896)3.52094505
91opsonization (GO:0008228)3.50423229
92cellular ketone body metabolic process (GO:0046950)3.49981911
93fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.47186987
94nitrogen cycle metabolic process (GO:0071941)3.46887325
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.45815437
96acetyl-CoA metabolic process (GO:0006084)3.43913471
97inner mitochondrial membrane organization (GO:0007007)3.43890487
98short-chain fatty acid metabolic process (GO:0046459)3.43339842
99regulation of mitochondrial translation (GO:0070129)3.42274688
100amine catabolic process (GO:0009310)3.42274666
101cellular biogenic amine catabolic process (GO:0042402)3.42274666
102response to nitrosative stress (GO:0051409)3.39738918
103cellular amino acid catabolic process (GO:0009063)3.38601018
104deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38596393
105ribosomal small subunit assembly (GO:0000028)3.38360222
106sterol biosynthetic process (GO:0016126)3.36901758
107regulation of ubiquitin-protein transferase activity (GO:0051438)3.36757858
108acyl-CoA metabolic process (GO:0006637)3.35149904
109thioester metabolic process (GO:0035383)3.35149904
110mitotic sister chromatid segregation (GO:0000070)3.34597194
111serine family amino acid metabolic process (GO:0009069)3.33958315
112mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.32333456
113thioester biosynthetic process (GO:0035384)3.31998814
114acyl-CoA biosynthetic process (GO:0071616)3.31998814
115indolalkylamine metabolic process (GO:0006586)3.31475006
116regulation of cholesterol esterification (GO:0010872)3.31266129
117positive regulation of ligase activity (GO:0051351)3.31254837
118glutamate metabolic process (GO:0006536)3.29774666
119plasma lipoprotein particle clearance (GO:0034381)3.27832734
120protein targeting to mitochondrion (GO:0006626)3.26208966
121mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.25586716
122regulation of cellular amine metabolic process (GO:0033238)3.25340885
123creatine metabolic process (GO:0006600)3.25248911
124cytolysis (GO:0019835)3.24914477
125regulation of ligase activity (GO:0051340)3.24797795
126protein complex biogenesis (GO:0070271)3.24317029
127histone exchange (GO:0043486)3.23586821
128kinetochore assembly (GO:0051382)3.23187805
129ketone body metabolic process (GO:1902224)3.22023480
130long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.21647556
131phenol-containing compound biosynthetic process (GO:0046189)3.21565620
132telomere maintenance via recombination (GO:0000722)3.21375819
133mitochondrial respiratory chain complex assembly (GO:0033108)3.18299565
134triglyceride homeostasis (GO:0070328)3.16770859
135acylglycerol homeostasis (GO:0055090)3.16770859
136bile acid and bile salt transport (GO:0015721)3.15501069
137cellular glucuronidation (GO:0052695)3.14944038
138DNA ligation (GO:0006266)3.14472943
139mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.14302837
140mitochondrial respiratory chain complex I assembly (GO:0032981)3.14302837
141NADH dehydrogenase complex assembly (GO:0010257)3.14302837
142mitotic recombination (GO:0006312)3.13803035
143purine nucleobase biosynthetic process (GO:0009113)3.13314580
144homocysteine metabolic process (GO:0050667)3.11409547
145establishment of viral latency (GO:0019043)3.10521595
146kinetochore organization (GO:0051383)3.10022852
147energy coupled proton transport, down electrochemical gradient (GO:0015985)3.09854448
148ATP synthesis coupled proton transport (GO:0015986)3.09854448
149plasma lipoprotein particle remodeling (GO:0034369)3.09136360
150protein-lipid complex remodeling (GO:0034368)3.09136360
151macromolecular complex remodeling (GO:0034367)3.09136360
152cholesterol efflux (GO:0033344)3.07355444
153positive regulation of triglyceride lipase activity (GO:0061365)3.07092159
154positive regulation of lipoprotein lipase activity (GO:0051006)3.07092159
155glycerophospholipid catabolic process (GO:0046475)3.07014037
156reverse cholesterol transport (GO:0043691)3.05818812
157positive regulation of cellular amine metabolic process (GO:0033240)3.05526352
158lysine catabolic process (GO:0006554)3.05515442
159lysine metabolic process (GO:0006553)3.05515442
160regulation of cholesterol metabolic process (GO:0090181)3.05440806
161DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.03874012
162serine family amino acid catabolic process (GO:0009071)3.03529389
163nucleotide transmembrane transport (GO:1901679)3.03096384
164glucuronate metabolic process (GO:0019585)3.02975539
165uronic acid metabolic process (GO:0006063)3.02975539
166establishment of protein localization to mitochondrion (GO:0072655)2.98962275
167protein localization to kinetochore (GO:0034501)2.98184561
168positive regulation of cell cycle arrest (GO:0071158)2.95924110
169oxidative phosphorylation (GO:0006119)2.95607842
170sister chromatid segregation (GO:0000819)2.92841784
171respiratory chain complex IV assembly (GO:0008535)2.92806272
172spliceosomal snRNP assembly (GO:0000387)2.92018595
173DNA replication-independent nucleosome assembly (GO:0006336)2.90917046
174DNA replication-independent nucleosome organization (GO:0034724)2.90917046
175spindle checkpoint (GO:0031577)2.90681869
176telomere maintenance via telomere lengthening (GO:0010833)2.89588842
177regulation of mitotic spindle checkpoint (GO:1903504)2.88236693
178regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.88236693
179protein localization to mitochondrion (GO:0070585)2.88032763
180response to superoxide (GO:0000303)2.86587978
181tricarboxylic acid cycle (GO:0006099)2.85226637
182G1/S transition of mitotic cell cycle (GO:0000082)2.85142604
183cell cycle G1/S phase transition (GO:0044843)2.85142604
184rRNA modification (GO:0000154)2.84045280
185antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.82628703
186regulation of cellular respiration (GO:0043457)2.81467070
187DNA replication checkpoint (GO:0000076)2.81040631
188transcription elongation from RNA polymerase III promoter (GO:0006385)2.79619643
189termination of RNA polymerase III transcription (GO:0006386)2.79619643
190mitotic metaphase plate congression (GO:0007080)2.78811354
191non-recombinational repair (GO:0000726)2.78153565
192double-strand break repair via nonhomologous end joining (GO:0006303)2.78153565
193nucleotide-excision repair, DNA gap filling (GO:0006297)2.77286279
194nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77083117
195mitotic spindle checkpoint (GO:0071174)2.75778197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.23294314
2E2F7_22180533_ChIP-Seq_HELA_Human6.25229514
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.37150530
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.08670844
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.41912295
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.24392177
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.87400762
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.78064845
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.66470658
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66036637
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61794474
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.59248544
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.58417440
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53802973
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29613826
16FOXM1_23109430_ChIP-Seq_U2OS_Human3.21432032
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.20366294
18CREB1_15753290_ChIP-ChIP_HEK293T_Human3.18326354
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15027610
20ETS1_20019798_ChIP-Seq_JURKAT_Human3.00585550
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.98181464
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94713836
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.93330094
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.92466087
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77538859
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.70543384
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54189107
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.50672424
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.37118818
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36472867
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35986078
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35003725
33ELK1_19687146_ChIP-ChIP_HELA_Human2.31214552
34DCP1A_22483619_ChIP-Seq_HELA_Human2.19147582
35AR_21909140_ChIP-Seq_LNCAP_Human2.10817531
36TAF15_26573619_Chip-Seq_HEK293_Human2.09230196
37FOXP3_21729870_ChIP-Seq_TREG_Human2.08810946
38GABP_19822575_ChIP-Seq_HepG2_Human2.02201623
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02078698
40VDR_23849224_ChIP-Seq_CD4+_Human1.97724960
41HTT_18923047_ChIP-ChIP_STHdh_Human1.92014797
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.89577969
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87161582
44XRN2_22483619_ChIP-Seq_HELA_Human1.84980476
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81924331
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81583414
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.80388049
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.79685421
49TTF2_22483619_ChIP-Seq_HELA_Human1.75214992
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74255202
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.73827376
52GBX2_23144817_ChIP-Seq_PC3_Human1.73628435
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72708037
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60742952
55* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58596120
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55977989
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55865851
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55106036
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54071442
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46449756
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42775016
62HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.41821801
63* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40054815
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39857980
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38871868
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37514603
67MYC_18940864_ChIP-ChIP_HL60_Human1.32542205
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28291160
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24140509
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24015221
71BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21236537
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20932413
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20932413
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20292321
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19398989
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18048479
77PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15474809
78KDM5A_27292631_Chip-Seq_BREAST_Human1.13237379
79IRF1_19129219_ChIP-ChIP_H3396_Human1.11664712
80TFEB_21752829_ChIP-Seq_HELA_Human1.11508506
81NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08562228
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08543196
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07479137
84PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07340767
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07211419
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06836987
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06342324
88VDR_22108803_ChIP-Seq_LS180_Human1.06255411
89NANOG_16153702_ChIP-ChIP_HESCs_Human1.03922058
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03555211
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03329211
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02991004
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02171466
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02031425
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02024283
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01889294
97* FOXA2_19822575_ChIP-Seq_HepG2_Human1.01574627
98KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.01010048
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00285701
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00000161
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99061823
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98699485
103ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93992355
104SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.93799818
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.93475508
106MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93086241
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92548447
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91636445
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91631128
110EOMES_21245162_ChIP-Seq_HESCs_Human0.89684789
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88988523
112NCOR_22424771_ChIP-Seq_293T_Human0.88803999
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88767671
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.87735590
115ER_23166858_ChIP-Seq_MCF-7_Human0.87719855
116SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87051758
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86790781
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85976507
119KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84839776
120SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84805293
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84554313
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84018768
123CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83420657
124ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82110774
125* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82008729
126NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81817936
127EED_16625203_ChIP-ChIP_MESCs_Mouse0.79095215
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79091350
129SOX2_16153702_ChIP-ChIP_HESCs_Human0.78581909
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78354379
131SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.78066118
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.78045119
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77730128
134SOX2_18555785_ChIP-Seq_MESCs_Mouse0.76576737
135CTCF_20526341_ChIP-Seq_ESCs_Human0.76568730
136EGR1_19032775_ChIP-ChIP_M12_Human0.76453847
137EZH2_27294783_Chip-Seq_ESCs_Mouse0.75989000
138OCT4_20526341_ChIP-Seq_ESCs_Human0.75944890
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75462515
140NANOG_19829295_ChIP-Seq_ESCs_Human0.74717935
141SOX2_19829295_ChIP-Seq_ESCs_Human0.74717935
142* HNF4A_19822575_ChIP-Seq_HepG2_Human0.74616272
143SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74332126
144* CBP_21632823_ChIP-Seq_H3396_Human0.74187267
145MYC_19915707_ChIP-ChIP_AK7_Human0.73501046
146TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73364107
147SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73118924
148KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.72246289
149TAL1_26923725_Chip-Seq_HPCs_Mouse0.72010923
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.71817284
151SUZ12_27294783_Chip-Seq_ESCs_Mouse0.71796903
152CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71072631
153GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70850942
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70501559
155ELF5_23300383_ChIP-Seq_T47D_Human0.70334963
156* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.69757733
157RXRA_24833708_ChIP-Seq_LIVER_Mouse0.69217068
158SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.68696935
159TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.68556962
160GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.68466490
161GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.68436741
162TRIM28_21343339_ChIP-Seq_HEK293_Human0.68281557
163POU5F1_16153702_ChIP-ChIP_HESCs_Human0.68173140
164JARID2_20075857_ChIP-Seq_MESCs_Mouse0.68044800
165* NANOG_20526341_ChIP-Seq_ESCs_Human0.67931209
166CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67729922
167PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.67721213
168EZH2_18974828_ChIP-Seq_MESCs_Mouse0.67246138
169RNF2_18974828_ChIP-Seq_MESCs_Mouse0.67246138
170SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.66777264
171* SRF_21415370_ChIP-Seq_HL-1_Mouse0.66402296
172PIAS1_25552417_ChIP-Seq_VCAP_Human0.66075103
173P300_19829295_ChIP-Seq_ESCs_Human0.65772807
174* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.65525062
175CTBP2_25329375_ChIP-Seq_LNCAP_Human0.65100857
176STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.64736290
177EZH2_27304074_Chip-Seq_ESCs_Mouse0.64308332
178POU3F2_20337985_ChIP-ChIP_501MEL_Human0.63922760
179SOX17_20123909_ChIP-Seq_XEN_Mouse0.63458512
180P53_21459846_ChIP-Seq_SAOS-2_Human0.63120696
181SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63025022
182JARID2_20064375_ChIP-Seq_MESCs_Mouse0.62224995
183SMAD3_21741376_ChIP-Seq_EPCs_Human0.62050352
184GABP_17652178_ChIP-ChIP_JURKAT_Human0.61990611
185NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.61319649
186CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.60321817

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation8.87743311
2MP0002139_abnormal_hepatobiliary_system6.14626245
3MP0005360_urolithiasis5.79087311
4MP0003806_abnormal_nucleotide_metabolis5.24459980
5MP0005085_abnormal_gallbladder_physiolo5.05777447
6MP0005365_abnormal_bile_salt4.73110439
7MP0008875_abnormal_xenobiotic_pharmacok4.09332414
8MP0000015_abnormal_ear_pigmentation3.75285980
9MP0000920_abnormal_myelination3.03530969
10MP0002095_abnormal_skin_pigmentation3.03355007
11MP0005083_abnormal_biliary_tract2.77003371
12MP0010094_abnormal_chromosome_stability2.63968977
13MP0002938_white_spotting2.62151725
14MP0000371_diluted_coat_color2.50147928
15MP0001666_abnormal_nutrient_absorption2.49389033
16MP0003195_calcinosis2.48707743
17MP0005332_abnormal_amino_acid2.47540039
18MP0003252_abnormal_bile_duct2.45767776
19MP0009840_abnormal_foam_cell2.41521555
20MP0002102_abnormal_ear_morphology2.39241935
21MP0004957_abnormal_blastocyst_morpholog2.34511020
22MP0010329_abnormal_lipoprotein_level2.25301816
23MP0008058_abnormal_DNA_repair2.23801642
24MP0001324_abnormal_eye_pigmentation2.20537381
25MP0005451_abnormal_body_composition2.15909235
26MP0003693_abnormal_embryo_hatching2.15448547
27MP0005174_abnormal_tail_pigmentation2.12173513
28MP0005377_hearing/vestibular/ear_phenot2.08554568
29MP0003878_abnormal_ear_physiology2.08554568
30MP0003111_abnormal_nucleus_morphology2.05744683
31MP0002877_abnormal_melanocyte_morpholog2.04669315
32MP0001529_abnormal_vocalization2.02463389
33MP0003329_amyloid_beta_deposits1.93917489
34MP0003880_abnormal_central_pattern1.93005637
35MP0003690_abnormal_glial_cell1.91623037
36MP0003077_abnormal_cell_cycle1.86976648
37MP0004381_abnormal_hair_follicle1.79501405
38MP0002118_abnormal_lipid_homeostasis1.77309703
39MP0005257_abnormal_intraocular_pressure1.75778823
40MP0005408_hypopigmentation1.74124890
41MP0001905_abnormal_dopamine_level1.65542402
42MP0003868_abnormal_feces_composition1.64684813
43MP0008932_abnormal_embryonic_tissue1.64227759
44MP0003950_abnormal_plasma_membrane1.62979452
45MP0004142_abnormal_muscle_tone1.56000995
46MP0002075_abnormal_coat/hair_pigmentati1.53648180
47MP0003646_muscle_fatigue1.53107926
48MP0003941_abnormal_skin_development1.51977316
49MP0003186_abnormal_redox_activity1.49811509
50MP0005584_abnormal_enzyme/coenzyme_acti1.48022410
51MP0004270_analgesia1.44393930
52MP0001186_pigmentation_phenotype1.41772413
53MP0003011_delayed_dark_adaptation1.40468615
54MP0000604_amyloidosis1.40242085
55MP0010030_abnormal_orbit_morphology1.37035331
56MP0003656_abnormal_erythrocyte_physiolo1.35801390
57MP0004043_abnormal_pH_regulation1.31716515
58MP0008007_abnormal_cellular_replicative1.30455472
59MP0001764_abnormal_homeostasis1.29909250
60MP0003191_abnormal_cellular_cholesterol1.29798007
61MP0004019_abnormal_vitamin_homeostasis1.29779459
62MP0006036_abnormal_mitochondrial_physio1.26910519
63MP0000609_abnormal_liver_physiology1.26233993
64MP0004147_increased_porphyrin_level1.24682426
65MP0005171_absent_coat_pigmentation1.21749861
66MP0005248_abnormal_Harderian_gland1.21210867
67MP0001293_anophthalmia1.17877700
68MP0009697_abnormal_copulation1.14994736
69MP0002272_abnormal_nervous_system1.14256573
70MP0009379_abnormal_foot_pigmentation1.14235042
71MP0004885_abnormal_endolymph1.13182090
72MP0005319_abnormal_enzyme/_coenzyme1.11971343
73MP0002138_abnormal_hepatobiliary_system1.11338030
74MP0005197_abnormal_uvea_morphology1.05459085
75MP0008057_abnormal_DNA_replication1.03761608
76MP0002229_neurodegeneration1.03633814
77MP0003786_premature_aging1.03566323
78MP0003136_yellow_coat_color1.03391563
79MP0003634_abnormal_glial_cell1.02270666
80MP0001661_extended_life_span0.98825602
81MP0003632_abnormal_nervous_system0.94882338
82MP0005084_abnormal_gallbladder_morpholo0.93907000
83MP0005636_abnormal_mineral_homeostasis0.92721837
84MP0002064_seizures0.92235156
85MP0009643_abnormal_urine_homeostasis0.90001686
86MP0005253_abnormal_eye_physiology0.87796064
87MP0005551_abnormal_eye_electrophysiolog0.83509347
88MP0006292_abnormal_olfactory_placode0.82286915
89MP0002822_catalepsy0.81899261
90MP0005410_abnormal_fertilization0.80670368
91MP0002638_abnormal_pupillary_reflex0.79984899
92MP0005376_homeostasis/metabolism_phenot0.78285373
93MP0003567_abnormal_fetal_cardiomyocyte0.76967042
94MP0002876_abnormal_thyroid_physiology0.76614707
95MP0005075_abnormal_melanosome_morpholog0.76095132
96MP0001486_abnormal_startle_reflex0.75908222
97MP0000639_abnormal_adrenal_gland0.75720437
98MP0010234_abnormal_vibrissa_follicle0.75603568
99MP0001440_abnormal_grooming_behavior0.75254118
100MP0000358_abnormal_cell_content/0.74884244
101MP0000350_abnormal_cell_proliferation0.74822985
102MP0000462_abnormal_digestive_system0.74455236
103MP0009765_abnormal_xenobiotic_induced0.73689038
104MP0001485_abnormal_pinna_reflex0.72775335
105MP0006035_abnormal_mitochondrial_morpho0.70877903
106MP0002295_abnormal_pulmonary_circulatio0.70435711
107MP0005647_abnormal_sex_gland0.69733449
108MP0004742_abnormal_vestibular_system0.69700358
109MP0001984_abnormal_olfaction0.69107453
110MP0009745_abnormal_behavioral_response0.69084003
111MP0005058_abnormal_lysosome_morphology0.67235696
112MP0008789_abnormal_olfactory_epithelium0.66877830
113MP0005266_abnormal_metabolism0.66115396
114MP0003631_nervous_system_phenotype0.65778898
115MP0002177_abnormal_outer_ear0.65336808
116MP0000747_muscle_weakness0.64337505
117MP0003890_abnormal_embryonic-extraembry0.63647486
118MP0009763_increased_sensitivity_to0.63633940
119MP0005535_abnormal_body_temperature0.63611831
120MP0000566_synostosis0.63024743
121MP0002837_dystrophic_cardiac_calcinosis0.60975769
122MP0009384_cardiac_valve_regurgitation0.60607814
123MP0001697_abnormal_embryo_size0.60550954
124MP0005391_vision/eye_phenotype0.59814888
125MP0002254_reproductive_system_inflammat0.59785849
126MP0002132_abnormal_respiratory_system0.59053948
127MP0005386_behavior/neurological_phenoty0.59044127
128MP0004924_abnormal_behavior0.59044127
129MP0000647_abnormal_sebaceous_gland0.58282654
130MP0005409_darkened_coat_color0.57675484
131MP0000598_abnormal_liver_morphology0.56984440
132MP0005220_abnormal_exocrine_pancreas0.56940264
133MP0002734_abnormal_mechanical_nocicepti0.56863898
134MP0004233_abnormal_muscle_weight0.56787689
135MP0000579_abnormal_nail_morphology0.56697084
136MP0008872_abnormal_physiological_respon0.56035200
137MP0000778_abnormal_nervous_system0.55902477
138MP0009642_abnormal_blood_homeostasis0.54994323
139MP0006276_abnormal_autonomic_nervous0.54164611
140MP0002090_abnormal_vision0.53958265
141MP0002080_prenatal_lethality0.53930682
142MP0002085_abnormal_embryonic_tissue0.53863017
143MP0003718_maternal_effect0.53536765
144MP0001730_embryonic_growth_arrest0.51824363
145MP0005193_abnormal_anterior_eye0.51613796
146MP0002396_abnormal_hematopoietic_system0.51405377
147MP0008874_decreased_physiological_sensi0.51002062
148MP0003633_abnormal_nervous_system0.50710668
149MP0002066_abnormal_motor_capabilities/c0.50344947
150MP0001664_abnormal_digestion0.50067996
151MP0005380_embryogenesis_phenotype0.49785931
152MP0001672_abnormal_embryogenesis/_devel0.49785931
153MP0002736_abnormal_nociception_after0.49597954
154MP0005195_abnormal_posterior_eye0.49402954
155MP0002084_abnormal_developmental_patter0.49254542
156MP0002092_abnormal_eye_morphology0.48536206
157MP0008260_abnormal_autophagy0.47274281
158MP0000313_abnormal_cell_death0.46035657
159* MP0002019_abnormal_tumor_incidence0.44237841
160MP0002697_abnormal_eye_size0.43109679
161MP0004133_heterotaxia0.42988516
162MP0003937_abnormal_limbs/digits/tail_de0.42970140
163MP0000537_abnormal_urethra_morphology0.42915817
164MP0001929_abnormal_gametogenesis0.42526775
165MP0002233_abnormal_nose_morphology0.42413997
166MP0002282_abnormal_trachea_morphology0.41415290
167MP0006054_spinal_hemorrhage0.39689491
168MP0002210_abnormal_sex_determination0.37954719
169MP0005395_other_phenotype0.35251158
170MP0009672_abnormal_birth_weight0.33763565
171MP0002111_abnormal_tail_morphology0.33250112
172MP0000749_muscle_degeneration0.32885244
173MP0005501_abnormal_skin_physiology0.32113376
174MP0002653_abnormal_ependyma_morphology0.31852565
175MP0000762_abnormal_tongue_morphology0.31482423
176MP0000367_abnormal_coat/_hair0.31477991
177MP0003119_abnormal_digestive_system0.30953918
178MP0003984_embryonic_growth_retardation0.29213816
179MP0005384_cellular_phenotype0.28838664

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the macula (HP:0008059)6.51146745
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.43010839
3Aplasia/Hypoplasia of the fovea (HP:0008060)6.07368067
4Hypoplasia of the fovea (HP:0007750)6.07368067
5Aplasia/Hypoplasia affecting the retina (HP:0008061)6.03109456
6Intrahepatic cholestasis (HP:0001406)5.92725035
7Abnormality of the fovea (HP:0000493)5.28173048
8Ocular albinism (HP:0001107)5.07609603
9Deep venous thrombosis (HP:0002625)4.91017645
10Patchy hypopigmentation of hair (HP:0011365)4.84897045
11Iris hypopigmentation (HP:0007730)4.83378874
12White forelock (HP:0002211)4.72089470
13Prolonged partial thromboplastin time (HP:0003645)4.57900314
14Abnormality of monocarboxylic acid metabolism (HP:0010996)4.36546678
15Hypobetalipoproteinemia (HP:0003563)4.35251178
16Xanthomatosis (HP:0000991)4.34121444
17Hyperlipoproteinemia (HP:0010980)4.13196432
18Complement deficiency (HP:0004431)3.99713539
19Blue irides (HP:0000635)3.81443079
20Neurofibrillary tangles (HP:0002185)3.70607115
21Fat malabsorption (HP:0002630)3.63318866
22Degeneration of anterior horn cells (HP:0002398)3.55209719
23Abnormality of the anterior horn cell (HP:0006802)3.55209719
24Abnormality of glycolysis (HP:0004366)3.51932907
25Increased serum pyruvate (HP:0003542)3.51932907
26Generalized hypopigmentation (HP:0007513)3.50221247
27Degeneration of the lateral corticospinal tracts (HP:0002314)3.48862494
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.48862494
29Abnormality of methionine metabolism (HP:0010901)3.47760421
30Cerebral edema (HP:0002181)3.42098799
31Acute encephalopathy (HP:0006846)3.32194259
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.29855057
33Abnormal auditory evoked potentials (HP:0006958)3.29829535
34Abnormal gallbladder physiology (HP:0012438)3.29003848
35Cholecystitis (HP:0001082)3.29003848
36Hyperammonemia (HP:0001987)3.17346819
37Steatorrhea (HP:0002570)3.14558644
38Acute necrotizing encephalopathy (HP:0006965)3.07710648
39Conjugated hyperbilirubinemia (HP:0002908)3.06883596
40Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.01130556
41Parakeratosis (HP:0001036)2.96795736
42Spastic paraparesis (HP:0002313)2.96532269
43Renal Fanconi syndrome (HP:0001994)2.95660446
44Ketosis (HP:0001946)2.95479081
45Hyperglycinemia (HP:0002154)2.93966239
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.93592643
47Hypolipoproteinemia (HP:0010981)2.92819922
48Sensory axonal neuropathy (HP:0003390)2.90370537
49Facial cleft (HP:0002006)2.89438361
50Reticulocytopenia (HP:0001896)2.89351232
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.88566171
52Hypopigmentation of the fundus (HP:0007894)2.88431614
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.88188680
54Abnormality of glycine metabolism (HP:0010895)2.84471199
55Abnormality of serine family amino acid metabolism (HP:0010894)2.84471199
56Leukodystrophy (HP:0002415)2.82845646
57Cerebral inclusion bodies (HP:0100314)2.82601975
58Abnormal mitochondria in muscle tissue (HP:0008316)2.78673133
59Mitochondrial inheritance (HP:0001427)2.75702025
60Epidermoid cyst (HP:0200040)2.73669588
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.70796131
62Freckling (HP:0001480)2.70273762
63Lethargy (HP:0001254)2.67994373
64Abnormality of the common coagulation pathway (HP:0010990)2.67703763
65Hepatocellular necrosis (HP:0001404)2.64124820
66Joint hemorrhage (HP:0005261)2.64017034
67Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.63509197
68Hepatic necrosis (HP:0002605)2.63077804
69Abnormality of complement system (HP:0005339)2.62135405
70Abnormality of fatty-acid metabolism (HP:0004359)2.62050516
71Abnormality of the corticospinal tract (HP:0002492)2.60668992
72Albinism (HP:0001022)2.58040330
73Premature graying of hair (HP:0002216)2.56551654
74Abnormal gallbladder morphology (HP:0012437)2.55478237
75Lipid accumulation in hepatocytes (HP:0006561)2.55075156
76Chromsome breakage (HP:0040012)2.53317434
77Abnormal lung lobation (HP:0002101)2.49704132
78Type I transferrin isoform profile (HP:0003642)2.48970566
79Progressive macrocephaly (HP:0004481)2.47885220
80Congenital stationary night blindness (HP:0007642)2.46664105
81Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.45530982
82Increased CSF lactate (HP:0002490)2.42951045
83Exercise intolerance (HP:0003546)2.42159046
84Cerebral hemorrhage (HP:0001342)2.39675304
85Increased hepatocellular lipid droplets (HP:0006565)2.38981693
863-Methylglutaconic aciduria (HP:0003535)2.36662716
87Duodenal stenosis (HP:0100867)2.36553250
88Small intestinal stenosis (HP:0012848)2.36553250
89Cholelithiasis (HP:0001081)2.36542206
90Cerebral hypomyelination (HP:0006808)2.36432254
91Hyperbilirubinemia (HP:0002904)2.36373086
92Methylmalonic acidemia (HP:0002912)2.36224230
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35989226
94Dicarboxylic aciduria (HP:0003215)2.35989226
95Cutaneous melanoma (HP:0012056)2.35164510
96Chronic bronchitis (HP:0004469)2.34570127
97Decreased central vision (HP:0007663)2.34551840
98Abnormality of glutamine family amino acid metabolism (HP:0010902)2.33594812
99Rhinitis (HP:0012384)2.31513691
100Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29979521
101Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29979521
102Metabolic acidosis (HP:0001942)2.29783173
103Abnormality of the intrinsic pathway (HP:0010989)2.29311528
104Increased serum lactate (HP:0002151)2.28892017
105Meckel diverticulum (HP:0002245)2.28300947
106Abnormal respiratory motile cilium physiology (HP:0012261)2.25387831
107Abnormality of serum amino acid levels (HP:0003112)2.25372456
108Opisthotonus (HP:0002179)2.24792662
109Abnormality of the preputium (HP:0100587)2.23915526
110Amyloidosis (HP:0011034)2.22362407
111Hypoglycemic coma (HP:0001325)2.21886634
112Hypoalphalipoproteinemia (HP:0003233)2.19982824
113Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.18077299
114Hyperglycinuria (HP:0003108)2.16987090
115Hypophosphatemic rickets (HP:0004912)2.16713923
116Abnormality of urine glucose concentration (HP:0011016)2.16685826
117Glycosuria (HP:0003076)2.16685826
118Sparse eyelashes (HP:0000653)2.16567606
119Increased intramyocellular lipid droplets (HP:0012240)2.16450211
120Abnormality of the ileum (HP:0001549)2.16336635
121Brushfield spots (HP:0001088)2.16292477
122Delayed CNS myelination (HP:0002188)2.15771092
123Respiratory difficulties (HP:0002880)2.14612730
124Bifid tongue (HP:0010297)2.13676203
125Increased muscle lipid content (HP:0009058)2.10604373
126Aplasia/Hypoplasia of the uvula (HP:0010293)2.08724698
127Abnormal respiratory motile cilium morphology (HP:0005938)2.06150682
128Abnormal respiratory epithelium morphology (HP:0012253)2.06150682
129Median cleft lip (HP:0000161)2.05205824
130Vomiting (HP:0002013)2.03548270
131Abnormality of chromosome stability (HP:0003220)2.03136657
132Paraparesis (HP:0002385)2.02090505
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01244708
134Multiple enchondromatosis (HP:0005701)2.00718267
135Abnormality of the gallbladder (HP:0005264)2.00385945
136Infantile muscular hypotonia (HP:0008947)1.99742676
137Spastic gait (HP:0002064)1.99105417
138Methylmalonic aciduria (HP:0012120)1.99012345
139Intestinal atresia (HP:0011100)1.98133758
140Abnormality of vitamin metabolism (HP:0100508)1.97231652
141Spontaneous abortion (HP:0005268)1.96716670
142Irritability (HP:0000737)1.96273849
143Lactic acidosis (HP:0003128)1.95671620
144Congenital ichthyosiform erythroderma (HP:0007431)1.95168500
145Abnormality of the duodenum (HP:0002246)1.94965926
146Respiratory failure (HP:0002878)1.94236266
147Selective tooth agenesis (HP:0001592)1.94008586
148Intention tremor (HP:0002080)1.93989007
149Ileus (HP:0002595)1.92916633
150Hypercholesterolemia (HP:0003124)1.92783103
151Ketoacidosis (HP:0001993)1.92564035
152Oral leukoplakia (HP:0002745)1.92435900
153Optic disc pallor (HP:0000543)1.91893106
154Congenital sensorineural hearing impairment (HP:0008527)1.90176227
155Abnormal number of erythroid precursors (HP:0012131)1.90029124
156Confusion (HP:0001289)1.89946397
157Birth length less than 3rd percentile (HP:0003561)1.89702978
158Autoamputation (HP:0001218)1.88594418
159Acanthocytosis (HP:0001927)1.88537652
160Macrocytic anemia (HP:0001972)1.88275393
161Abnormal protein glycosylation (HP:0012346)1.85762887
162Abnormal glycosylation (HP:0012345)1.85762887
163Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85762887
164Abnormal protein N-linked glycosylation (HP:0012347)1.85762887
165Abnormal ciliary motility (HP:0012262)1.84870244
166Adrenal hypoplasia (HP:0000835)1.84289790
167Neoplasm of the adrenal gland (HP:0100631)1.82414363
168Exertional dyspnea (HP:0002875)1.78486251
169Microvesicular hepatic steatosis (HP:0001414)1.78419018
170Reduced antithrombin III activity (HP:0001976)1.77194151
171Astigmatism (HP:0000483)1.75629384
172CNS demyelination (HP:0007305)1.71727465
173Colon cancer (HP:0003003)1.71626125
174Neoplasm of the colon (HP:0100273)1.71132195
175Abnormality of cells of the erythroid lineage (HP:0012130)1.70855283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.59538139
2WEE15.05178429
3BUB14.08793840
4OXSR14.06047631
5VRK23.81729920
6BCKDK3.54378899
7PDK23.41016269
8BCR2.97152836
9PBK2.92510464
10MET2.85679139
11CDC72.65379684
12PKN12.53674602
13TTK2.41980657
14CSNK1G32.40903148
15WNK42.37788274
16NEK12.34772308
17ERBB42.29943351
18CDK192.25736333
19FGFR22.24027851
20EIF2AK12.24025280
21PLK32.13880495
22LIMK12.09370059
23EPHB12.07632400
24CSNK1A1L2.00898650
25SRPK11.91149242
26CSNK1G11.87230453
27TRIM281.85730474
28ZAK1.72121121
29CAMK2B1.71452209
30TESK21.68925171
31CSNK1G21.68114010
32VRK11.66024501
33PLK41.65986415
34MAPKAPK51.65492825
35ARAF1.64180778
36EIF2AK31.63447249
37CAMK2G1.59793719
38EPHA41.56105700
39PLK11.52632820
40TSSK61.50236080
41PRPF4B1.48253261
42MST1R1.46288876
43CAMK2D1.44290012
44MARK31.42413061
45PLK21.41973762
46NEK61.37980525
47MAP3K121.36125694
48NME11.34610069
49NTRK11.33707418
50FGR1.32156611
51PAK41.27721214
52STK161.25536034
53BRSK11.24056081
54UHMK11.23400952
55NUAK11.20238748
56ACVR1B1.19189041
57ATR1.16498464
58WNK11.12451411
59NEK21.11122923
60ROCK21.11080622
61ICK1.10537846
62MAPK151.08885363
63MST41.04642456
64BRSK21.04445899
65CASK1.04122197
66AURKB1.03866068
67MKNK11.00603743
68CAMK2A0.99630801
69CDK70.95213122
70CHEK20.93629988
71DYRK20.92733420
72ABL20.92519578
73TAF10.90782429
74PRKCQ0.90163533
75SGK4940.90000956
76SGK2230.90000956
77TNIK0.87942329
78TGFBR10.86935174
79INSRR0.86074058
80MKNK20.85510557
81EPHA20.84427980
82STK40.82236495
83FGFR40.81345436
84STK30.79679834
85PIK3CG0.78927827
86ERBB30.76237151
87ADRBK20.75835367
88WNK30.74295288
89SIK10.72403575
90PAK30.72338433
91EIF2AK20.72240923
92MYLK0.71739151
93GRK70.71428250
94OBSCN0.70431043
95CDK140.70042467
96PNCK0.68982163
97MUSK0.67528981
98PIK3CA0.65242869
99BMPR1B0.64461300
100CCNB10.64006410
101PIM20.63807263
102TRPM70.61910022
103MAP2K40.60883222
104AURKA0.60306114
105MAP2K20.59542461
106FER0.59457300
107CDK150.58255816
108PAK60.57932382
109DAPK10.57807919
110CDK50.57044063
111CSNK2A10.56449434
112PTK2B0.54775176
113ATM0.54181054
114FLT30.53089330
115CDK180.52744299
116PDPK10.52596948
117MAP3K130.52119393
118ERN10.51414340
119TESK10.51353529
120CDK11A0.51283872
121GSK3A0.49385404
122CSNK2A20.49154972
123DAPK30.48916974
124MAP3K80.48053940
125BMPR20.47744115
126TAOK30.47667185
127PRKD10.47116575
128AKT20.47102727
129PRKACB0.46649108
130PRKCE0.46628850
131DAPK20.46508036
132MAPK120.46035777
133PRKG10.44743219
134MAP4K20.44663632
135CHEK10.44468547
136PAK10.43286406
137MAPK40.43067110
138LRRK20.41784920
139PRKCZ0.41746045
140GRK10.41551268
141SCYL20.40454240
142ERBB20.40247744
143STK100.40196998
144FYN0.39657317
145IRAK20.39134267
146MOS0.39081785
147STK38L0.38849234
148BRAF0.38714603
149KDR0.38484733
150GRK50.37387930
151PHKG20.37025972
152PHKG10.37025972
153CSNK1A10.36897731
154* PRKACA0.36612578
155MAPK110.35721200
156NME20.34873442
157CSNK1D0.34504615
158PASK0.34483849
159LATS10.34420206
160PINK10.33911016
161LMTK20.33888319
162CLK10.32938100
163ITK0.31106391
164GRK60.30137679
165RPS6KB20.29825631
166SMG10.28709511
167ILK0.28587824
168TLK10.28164084
169CDK10.27996225
170MAP3K30.27162031

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.81870867
2DNA replication_Homo sapiens_hsa030303.34869570
3Mismatch repair_Homo sapiens_hsa034303.34020555
4Fatty acid elongation_Homo sapiens_hsa000622.99629146
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.89608721
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.88293742
7Homologous recombination_Homo sapiens_hsa034402.71367073
8Steroid biosynthesis_Homo sapiens_hsa001002.63273451
9Nitrogen metabolism_Homo sapiens_hsa009102.54335337
10Non-homologous end-joining_Homo sapiens_hsa034502.54244535
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38065538
12Base excision repair_Homo sapiens_hsa034102.31674534
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29359419
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28188830
15RNA polymerase_Homo sapiens_hsa030202.27064094
16Histidine metabolism_Homo sapiens_hsa003402.23237853
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.21630779
18Sulfur metabolism_Homo sapiens_hsa009202.21298786
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20401953
20Arginine biosynthesis_Homo sapiens_hsa002202.17596886
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.14292956
22Tryptophan metabolism_Homo sapiens_hsa003802.13271866
23Butanoate metabolism_Homo sapiens_hsa006502.12220924
24Oxidative phosphorylation_Homo sapiens_hsa001902.10219819
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.07749167
26Complement and coagulation cascades_Homo sapiens_hsa046102.06408951
27* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02172838
28Peroxisome_Homo sapiens_hsa041461.96182555
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.95550496
30Propanoate metabolism_Homo sapiens_hsa006401.90964638
31Fatty acid degradation_Homo sapiens_hsa000711.85735813
32Nucleotide excision repair_Homo sapiens_hsa034201.79684053
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.76281601
34Folate biosynthesis_Homo sapiens_hsa007901.73324335
35Fanconi anemia pathway_Homo sapiens_hsa034601.72908056
36Pyrimidine metabolism_Homo sapiens_hsa002401.72123064
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70295239
38* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.69240158
39Vitamin B6 metabolism_Homo sapiens_hsa007501.68091715
40Spliceosome_Homo sapiens_hsa030401.67567609
41* Chemical carcinogenesis_Homo sapiens_hsa052041.66840631
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63767154
43Parkinsons disease_Homo sapiens_hsa050121.62473590
44Fatty acid metabolism_Homo sapiens_hsa012121.61354110
45Tyrosine metabolism_Homo sapiens_hsa003501.61032040
46RNA transport_Homo sapiens_hsa030131.53282428
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.47587003
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45283385
49Retinol metabolism_Homo sapiens_hsa008301.44628219
50Cell cycle_Homo sapiens_hsa041101.42385226
51Protein export_Homo sapiens_hsa030601.42283873
52Pyruvate metabolism_Homo sapiens_hsa006201.41858134
53Arginine and proline metabolism_Homo sapiens_hsa003301.41125529
54beta-Alanine metabolism_Homo sapiens_hsa004101.37275354
55Phenylalanine metabolism_Homo sapiens_hsa003601.36262385
56Caffeine metabolism_Homo sapiens_hsa002321.35615152
57PPAR signaling pathway_Homo sapiens_hsa033201.31652079
58Alzheimers disease_Homo sapiens_hsa050101.27676044
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.22269226
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20822937
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19812390
62RNA degradation_Homo sapiens_hsa030181.17839501
63Drug metabolism - other enzymes_Homo sapiens_hsa009831.17835428
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13720864
65Fat digestion and absorption_Homo sapiens_hsa049751.11936455
66Purine metabolism_Homo sapiens_hsa002301.07610495
67* Glutathione metabolism_Homo sapiens_hsa004801.07491795
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00702171
69Biosynthesis of amino acids_Homo sapiens_hsa012301.00005817
70Bile secretion_Homo sapiens_hsa049760.98985890
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98452896
72Ether lipid metabolism_Homo sapiens_hsa005650.97671649
73Carbon metabolism_Homo sapiens_hsa012000.96214567
74p53 signaling pathway_Homo sapiens_hsa041150.95861347
75Basal transcription factors_Homo sapiens_hsa030220.94425520
76Staphylococcus aureus infection_Homo sapiens_hsa051500.93305349
77Linoleic acid metabolism_Homo sapiens_hsa005910.89963467
78Selenocompound metabolism_Homo sapiens_hsa004500.87701696
79Huntingtons disease_Homo sapiens_hsa050160.87268487
80Sulfur relay system_Homo sapiens_hsa041220.85736120
81Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84852112
82Vitamin digestion and absorption_Homo sapiens_hsa049770.82892794
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.81702998
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81642504
85Metabolic pathways_Homo sapiens_hsa011000.81379892
86ABC transporters_Homo sapiens_hsa020100.78829064
87Starch and sucrose metabolism_Homo sapiens_hsa005000.78403406
88N-Glycan biosynthesis_Homo sapiens_hsa005100.77302810
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.66527578
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59721049
91Glycerolipid metabolism_Homo sapiens_hsa005610.55008393
92Pentose phosphate pathway_Homo sapiens_hsa000300.53316998
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52761892
94Oocyte meiosis_Homo sapiens_hsa041140.51740803
95Prion diseases_Homo sapiens_hsa050200.50485739
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50462187
97Proteasome_Homo sapiens_hsa030500.49682813
98Galactose metabolism_Homo sapiens_hsa000520.47306523
99Cardiac muscle contraction_Homo sapiens_hsa042600.44840452
100Arachidonic acid metabolism_Homo sapiens_hsa005900.43641226
101Epstein-Barr virus infection_Homo sapiens_hsa051690.42433756
102mRNA surveillance pathway_Homo sapiens_hsa030150.41644459
103Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37850118
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32325004
105Sphingolipid metabolism_Homo sapiens_hsa006000.30303960
106Systemic lupus erythematosus_Homo sapiens_hsa053220.27591294
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27191181
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.26858547
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26623883
110Fatty acid biosynthesis_Homo sapiens_hsa000610.26217480
111Collecting duct acid secretion_Homo sapiens_hsa049660.25038603
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22137509
113Tight junction_Homo sapiens_hsa045300.21149381
114Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19667799
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17459211
116Basal cell carcinoma_Homo sapiens_hsa052170.16670383
117Hippo signaling pathway_Homo sapiens_hsa043900.15850687
118Vibrio cholerae infection_Homo sapiens_hsa051100.15661363
119GABAergic synapse_Homo sapiens_hsa047270.14954703
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14028843
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11966362
122Fructose and mannose metabolism_Homo sapiens_hsa000510.11237424
123Regulation of autophagy_Homo sapiens_hsa041400.08138220
124One carbon pool by folate_Homo sapiens_hsa006700.06198691
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.03937943
126Ovarian steroidogenesis_Homo sapiens_hsa049130.03860464
127Axon guidance_Homo sapiens_hsa043600.03352421
128Pancreatic secretion_Homo sapiens_hsa049720.03029356
129Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02931948
130Mineral absorption_Homo sapiens_hsa049780.01158761
131Serotonergic synapse_Homo sapiens_hsa04726-0.0797493
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0319786
133Ribosome_Homo sapiens_hsa03010-0.0319069
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0303889
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0258741
136Lysine degradation_Homo sapiens_hsa00310-0.0093874

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