GSTT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, glutathione S-transferase (GST) theta 1 (GSTT1), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT1 and GSTT2/GSTT2B share 55% amino acid sequence identity and may play a role in human carcinogenesis. The GSTT1 gene is haplotype-specific and is absent from 38% of the population. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.44238947
2L-phenylalanine catabolic process (GO:0006559)7.44238947
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.13230395
4L-phenylalanine metabolic process (GO:0006558)7.13230395
5aromatic amino acid family catabolic process (GO:0009074)6.61760958
6regulation of skeletal muscle contraction (GO:0014819)6.49063576
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.11638998
8indole-containing compound catabolic process (GO:0042436)5.88047579
9indolalkylamine catabolic process (GO:0046218)5.88047579
10tryptophan catabolic process (GO:0006569)5.88047579
11bile acid biosynthetic process (GO:0006699)5.73872119
12kynurenine metabolic process (GO:0070189)5.69315204
13glyoxylate metabolic process (GO:0046487)5.68933114
14tryptophan metabolic process (GO:0006568)5.55770876
15alpha-linolenic acid metabolic process (GO:0036109)5.48636544
16cysteine metabolic process (GO:0006534)5.40479674
17sulfur amino acid catabolic process (GO:0000098)5.34806019
18high-density lipoprotein particle remodeling (GO:0034375)5.34203201
19urea cycle (GO:0000050)5.31592575
20urea metabolic process (GO:0019627)5.31592575
21negative regulation of fibrinolysis (GO:0051918)5.22458949
22peptidyl-glutamic acid carboxylation (GO:0017187)5.11975493
23protein carboxylation (GO:0018214)5.11975493
24regulation of fibrinolysis (GO:0051917)5.04147372
25complement activation, alternative pathway (GO:0006957)5.01300001
26serine family amino acid catabolic process (GO:0009071)4.99354777
27regulation of protein activation cascade (GO:2000257)4.93400359
28homocysteine metabolic process (GO:0050667)4.91037764
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.90793821
30bile acid metabolic process (GO:0008206)4.89963393
31nitrogen cycle metabolic process (GO:0071941)4.89620008
32negative regulation of cell aging (GO:0090344)4.83321275
33aromatic amino acid family metabolic process (GO:0009072)4.80321954
34transepithelial transport (GO:0070633)4.75784117
35regulation of triglyceride catabolic process (GO:0010896)4.75504064
36reverse cholesterol transport (GO:0043691)4.73382522
37regulation of cholesterol esterification (GO:0010872)4.73251199
38lysine metabolic process (GO:0006553)4.71963071
39lysine catabolic process (GO:0006554)4.71963071
40DNA strand renaturation (GO:0000733)4.67889182
41detection of light stimulus involved in sensory perception (GO:0050962)4.66028945
42detection of light stimulus involved in visual perception (GO:0050908)4.66028945
43tyrosine metabolic process (GO:0006570)4.63762805
44regulation of complement activation (GO:0030449)4.61960836
45alpha-amino acid catabolic process (GO:1901606)4.57467582
46plasma lipoprotein particle remodeling (GO:0034369)4.57301615
47protein-lipid complex remodeling (GO:0034368)4.57301615
48macromolecular complex remodeling (GO:0034367)4.57301615
49cellular response to ATP (GO:0071318)4.56959094
50amino-acid betaine metabolic process (GO:0006577)4.56740737
51cellular ketone body metabolic process (GO:0046950)4.53767186
52mitotic cell cycle arrest (GO:0071850)4.53022241
53regulation of synapse structural plasticity (GO:0051823)4.49723870
54acylglycerol homeostasis (GO:0055090)4.45312046
55triglyceride homeostasis (GO:0070328)4.45312046
56phospholipid efflux (GO:0033700)4.44959245
57negative regulation of cholesterol transport (GO:0032375)4.43543383
58negative regulation of sterol transport (GO:0032372)4.43543383
59cellular amino acid catabolic process (GO:0009063)4.25272643
60plasma lipoprotein particle clearance (GO:0034381)4.22660660
61bile acid and bile salt transport (GO:0015721)4.19480197
62indolalkylamine metabolic process (GO:0006586)4.18556252
63GDP-mannose metabolic process (GO:0019673)4.16536383
64coenzyme catabolic process (GO:0009109)4.16276926
65glycine metabolic process (GO:0006544)4.15028873
66cellular glucuronidation (GO:0052695)4.14221278
67glutamate metabolic process (GO:0006536)4.13063568
68benzene-containing compound metabolic process (GO:0042537)4.11839644
69serine family amino acid metabolic process (GO:0009069)4.10451211
70drug catabolic process (GO:0042737)4.10002585
71amine catabolic process (GO:0009310)4.08785933
72cellular biogenic amine catabolic process (GO:0042402)4.08785933
73cellular modified amino acid catabolic process (GO:0042219)4.06351403
74respiratory chain complex IV assembly (GO:0008535)4.04387104
75imidazole-containing compound metabolic process (GO:0052803)4.03466059
76cholesterol efflux (GO:0033344)4.03138847
77ethanol oxidation (GO:0006069)4.03131498
78regulation of cytokine production involved in inflammatory response (GO:1900015)3.97866886
79estrogen biosynthetic process (GO:0006703)3.95108316
80ketone body metabolic process (GO:1902224)3.92300924
81serine family amino acid biosynthetic process (GO:0009070)3.90186792
82short-chain fatty acid metabolic process (GO:0046459)3.89447320
83plasma lipoprotein particle assembly (GO:0034377)3.86368674
84arginine metabolic process (GO:0006525)3.84619359
85aldehyde catabolic process (GO:0046185)3.84110986
86low-density lipoprotein particle remodeling (GO:0034374)3.83860477
87dicarboxylic acid biosynthetic process (GO:0043650)3.83178789
88behavioral response to nicotine (GO:0035095)3.80080169
89organic acid catabolic process (GO:0016054)3.78727596
90carboxylic acid catabolic process (GO:0046395)3.78727596
91fibrinolysis (GO:0042730)3.76094393
92drug transmembrane transport (GO:0006855)3.73849006
93cytochrome complex assembly (GO:0017004)3.71083136
94uronic acid metabolic process (GO:0006063)3.70216253
95glucuronate metabolic process (GO:0019585)3.70216253
96response to nitrosative stress (GO:0051409)3.67654423
97phospholipid homeostasis (GO:0055091)3.67548449
98positive regulation of triglyceride lipase activity (GO:0061365)3.67477936
99positive regulation of lipoprotein lipase activity (GO:0051006)3.67477936
100positive regulation of lipid catabolic process (GO:0050996)3.66909808
101water-soluble vitamin biosynthetic process (GO:0042364)3.66594060
102acetyl-CoA metabolic process (GO:0006084)3.65615520
103regulation of bile acid biosynthetic process (GO:0070857)3.63373373
104negative regulation of lipase activity (GO:0060192)3.63292980
105flavonoid metabolic process (GO:0009812)3.62507968
106cholesterol homeostasis (GO:0042632)3.62397466
107cofactor catabolic process (GO:0051187)3.58816977
108regulation of cholesterol homeostasis (GO:2000188)3.58774593
109urate metabolic process (GO:0046415)3.57847824
110very-low-density lipoprotein particle assembly (GO:0034379)3.57805748
111sterol homeostasis (GO:0055092)3.56888542
112blood coagulation, intrinsic pathway (GO:0007597)3.56685236
113monocarboxylic acid catabolic process (GO:0072329)3.56336413
114fatty acid beta-oxidation (GO:0006635)3.56238364
115fatty acid oxidation (GO:0019395)3.54091945
116drug metabolic process (GO:0017144)3.54066459
117cilium or flagellum-dependent cell motility (GO:0001539)3.35670265
118protein complex biogenesis (GO:0070271)3.28770566
119peptidyl-glutamic acid modification (GO:0018200)3.23452455
120heme transport (GO:0015886)3.23095735
121axoneme assembly (GO:0035082)3.07725975
122preassembly of GPI anchor in ER membrane (GO:0016254)3.07367047
123lens fiber cell differentiation (GO:0070306)3.01296128
124mannosylation (GO:0097502)2.98465972
125ATP synthesis coupled proton transport (GO:0015986)2.97815622
126energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97815622
127regulation of phospholipid biosynthetic process (GO:0071071)2.94522630
128phosphatidylglycerol biosynthetic process (GO:0006655)2.93859537
129mitochondrial respiratory chain complex I assembly (GO:0032981)2.92641557
130NADH dehydrogenase complex assembly (GO:0010257)2.92641557
131mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92641557
132iron coordination entity transport (GO:1901678)2.89412949
133mitochondrial respiratory chain complex assembly (GO:0033108)2.87484873
134response to gravity (GO:0009629)2.87095012
1353-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.85810777
136purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.85810777
137nephron tubule morphogenesis (GO:0072078)2.85651167
138nephron epithelium morphogenesis (GO:0072088)2.85651167
139phosphatidylethanolamine biosynthetic process (GO:0006646)2.75235296
140rRNA modification (GO:0000154)2.75131162
141positive regulation of heat generation (GO:0031652)2.74216970
142detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73717842
143dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.70768951
144mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.69495755
145mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68379160
146rRNA methylation (GO:0031167)2.67489323
147cardiolipin metabolic process (GO:0032048)2.63375377
148trivalent inorganic anion homeostasis (GO:0072506)2.63100194
149phosphate ion homeostasis (GO:0055062)2.63100194
150meiotic chromosome segregation (GO:0045132)2.62809988
151nucleoside transmembrane transport (GO:1901642)2.62595368
152epithelial cilium movement (GO:0003351)2.59019720
153neuromuscular synaptic transmission (GO:0007274)2.58937852
154nonribosomal peptide biosynthetic process (GO:0019184)2.58556773
155base-excision repair, AP site formation (GO:0006285)2.57412256
156nucleotide transmembrane transport (GO:1901679)2.56961932
157L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.56221620
158purinergic nucleotide receptor signaling pathway (GO:0035590)2.54632429
159phosphatidylethanolamine metabolic process (GO:0046337)2.53285043
160GPI anchor biosynthetic process (GO:0006506)2.53039239
161positive regulation of TOR signaling (GO:0032008)2.50679089
162GPI anchor metabolic process (GO:0006505)2.49053988
163sulfation (GO:0051923)2.47697785
164urinary tract smooth muscle contraction (GO:0014848)2.45589736
165peptidyl-histidine modification (GO:0018202)2.45078040
166peristalsis (GO:0030432)2.41914975
167regulation of heat generation (GO:0031650)2.41826648
168glutathione biosynthetic process (GO:0006750)2.41768667
169intestinal cholesterol absorption (GO:0030299)2.40738946
170C-terminal protein lipidation (GO:0006501)2.40493708
171L-methionine biosynthetic process (GO:0071265)2.39565412
172amino acid salvage (GO:0043102)2.39565412
173L-methionine salvage (GO:0071267)2.39565412
174response to ATP (GO:0033198)2.38408204
175pseudouridine synthesis (GO:0001522)2.38054292
176protein import into peroxisome matrix (GO:0016558)2.37425278
177vitamin biosynthetic process (GO:0009110)2.37180608
178photoreceptor cell development (GO:0042461)2.36631765
179epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.35878630
180positive regulation of protein kinase C signaling (GO:0090037)2.35637145
181renal absorption (GO:0070293)2.35600319
182phosphatidylcholine biosynthetic process (GO:0006656)2.34969220
183electron transport chain (GO:0022900)2.34747871
184branched-chain amino acid catabolic process (GO:0009083)2.33899062
185NAD biosynthetic process (GO:0009435)2.31166341
186phenol-containing compound catabolic process (GO:0019336)2.30383983

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.11936932
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.94339769
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.63121169
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.30492082
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.14058721
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.05982221
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.86512932
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.98956467
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.74601671
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.91715983
11DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.36580766
12P68_20966046_ChIP-Seq_HELA_Human2.28287796
13E2F1_20622854_ChIP-Seq_HELA_Human2.22608938
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20690180
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15170349
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08877855
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08697582
18CTCF_27219007_Chip-Seq_Bcells_Human2.02725053
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02154573
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01737450
21XRN2_22483619_ChIP-Seq_HELA_Human2.00804603
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.4964292
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99110774
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.98540437
25GATA1_22025678_ChIP-Seq_K562_Human1.91485347
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.89690741
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83889486
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83130662
29CLOCK_20551151_ChIP-Seq_293T_Human1.81489267
30ERA_21632823_ChIP-Seq_H3396_Human1.80242992
31BCL6_27268052_Chip-Seq_Bcells_Human1.79051429
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.76828426
33PHF8_20622854_ChIP-Seq_HELA_Human1.76810746
34FOXP1_21924763_ChIP-Seq_HESCs_Human1.76162484
35CTCF_20526341_ChIP-Seq_ESCs_Human1.70738820
36ZNF274_21170338_ChIP-Seq_K562_Hela1.68882373
37BCOR_27268052_Chip-Seq_Bcells_Human1.67963306
38MYC_19829295_ChIP-Seq_ESCs_Human1.66663621
39TP53_22573176_ChIP-Seq_HFKS_Human1.64686939
40NANOG_20526341_ChIP-Seq_ESCs_Human1.62785582
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.62681588
42SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.58781108
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.57531507
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.56883669
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55097613
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.52781566
47EWS_26573619_Chip-Seq_HEK293_Human1.50608620
48OCT4_20526341_ChIP-Seq_ESCs_Human1.50173978
49VDR_22108803_ChIP-Seq_LS180_Human1.48025648
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44980711
51* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.43437139
52HTT_18923047_ChIP-ChIP_STHdh_Human1.41930792
53MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.38219545
54* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37305448
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.33888328
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33368497
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33089047
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30797547
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28197888
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.25770497
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24722789
62SA1_27219007_Chip-Seq_Bcells_Human1.24473061
63CTCF_21964334_Chip-Seq_Bcells_Human1.24031011
64SOX2_21211035_ChIP-Seq_LN229_Human1.23807101
65EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.23349849
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.23229897
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.20737425
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20486875
69SMC4_20622854_ChIP-Seq_HELA_Human1.18464344
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17022077
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15760811
72NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.15432590
73SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14998221
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.14602696
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14560280
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14396855
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13329514
78TP53_22127205_ChIP-Seq_IMR90_Human1.11812573
79RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10881468
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.10216307
81FUS_26573619_Chip-Seq_HEK293_Human1.09155176
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08987871
83SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08956900
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08658550
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.08382420
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.08134905
87SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05898083
88CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05777428
89GABP_19822575_ChIP-Seq_HepG2_Human1.04737644
90IGF1R_20145208_ChIP-Seq_DFB_Human1.04448937
91VDR_23849224_ChIP-Seq_CD4+_Human1.02342846
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02132773
93CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01595010
94VDR_21846776_ChIP-Seq_THP-1_Human1.00671291
95NCOR_22424771_ChIP-Seq_293T_Human0.99138007
96RAC3_21632823_ChIP-Seq_H3396_Human0.99101539
97P300_27268052_Chip-Seq_Bcells_Human0.98077976
98GATA4_25053715_ChIP-Seq_YYC3_Human0.96915577
99FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96592248
100SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96313831
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94808566
102GATA3_21867929_ChIP-Seq_CD8_Mouse0.94155345
103RACK7_27058665_Chip-Seq_MCF-7_Human0.92988218
104JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92521956
105ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92500307
106IRF8_22096565_ChIP-ChIP_GC-B_Human0.92169902
107PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91848127
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88977904
109ESR2_21235772_ChIP-Seq_MCF-7_Human0.88789437
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86144125
111ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85405338
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84630660
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82281392
114AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81793520
115* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80630937
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.76716004
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75595319
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73426113
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72991805
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72872426
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72872426
122KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72324787
123Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71731973
124BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71516736
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.69319937
126* RARA_24833708_ChIP-Seq_LIVER_Mouse0.68830352
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.68654134
128ZNF263_19887448_ChIP-Seq_K562_Human0.68327507
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68182737
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68131407
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67515506
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.65939727
133EGR1_19032775_ChIP-ChIP_M12_Human0.60132697
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58693669
135AR_20517297_ChIP-Seq_VCAP_Human0.58691851
136RARB_24833708_ChIP-Seq_LIVER_Mouse0.58217855
137* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57240091
138LXR_22292898_ChIP-Seq_THP-1_Human0.57087377
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.56631513
140TRIM28_21343339_ChIP-Seq_HEK293_Human0.56441859
141CEBPB_22108803_ChIP-Seq_LS180_Human0.56098065
142PPAR_26484153_Chip-Seq_NCI-H1993_Human0.55653417
143MYC_19915707_ChIP-ChIP_AK7_Human0.53750448
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53397336
145PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51512935
146SOX2_20726797_ChIP-Seq_SW620_Human0.51253942
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.50936995
148ESET_19884257_ChIP-Seq_ESCs_Mouse0.50220970
149FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.50162720
150BCAT_22108803_ChIP-Seq_LS180_Human0.50145474
151STAT1_17558387_ChIP-Seq_HELA_Human0.49790964
152CBP_21632823_ChIP-Seq_H3396_Human0.49412035
153SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.49253803
154ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.49049820
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.48977618
156GATA1_19941826_ChIP-Seq_K562_Human0.48371451
157E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.47121992
158GATA2_19941826_ChIP-Seq_K562_Human0.47081365
159TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.46896896
160GATA1_19941827_ChIP-Seq_MEL_Mouse0.46577698
161FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46551874
162GATA6_25053715_ChIP-Seq_YYC3_Human0.46271810
163P53_21459846_ChIP-Seq_SAOS-2_Human0.45955410
164PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45763577
165FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45184957
166ESR1_20079471_ChIP-ChIP_T-47D_Human0.44549450
167TAF2_19829295_ChIP-Seq_ESCs_Human0.43189518
168NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.43030035
169GATA3_24758297_ChIP-Seq_MCF-7_Human0.42450696
170ERG_21242973_ChIP-ChIP_JURKAT_Human0.42080515
171SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41366391
172GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.39439524
173ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39406449
174ERG_20517297_ChIP-Seq_VCAP_Human0.39097372
175CDX2_22108803_ChIP-Seq_LS180_Human0.38547259
176CSB_26484114_Chip-Seq_FIBROBLAST_Human0.37540283
177* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.37465914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.16351952
2MP0005360_urolithiasis7.48085451
3MP0005085_abnormal_gallbladder_physiolo6.23665670
4MP0005365_abnormal_bile_salt6.09112875
5MP0005171_absent_coat_pigmentation4.92008646
6* MP0008875_abnormal_xenobiotic_pharmacok4.86339663
7MP0003136_yellow_coat_color4.27002735
8MP0003806_abnormal_nucleotide_metabolis4.01246977
9MP0003252_abnormal_bile_duct3.91467123
10MP0001986_abnormal_taste_sensitivity3.74194056
11MP0005174_abnormal_tail_pigmentation3.61634344
12MP0010329_abnormal_lipoprotein_level3.50250884
13MP0005423_abnormal_somatic_nervous3.29614254
14MP0005083_abnormal_biliary_tract3.12447601
15MP0009840_abnormal_foam_cell3.10499154
16MP0003195_calcinosis2.94589748
17MP0005332_abnormal_amino_acid2.90316502
18MP0001968_abnormal_touch/_nociception2.88326902
19MP0002736_abnormal_nociception_after2.83472541
20MP0001666_abnormal_nutrient_absorption2.72074600
21MP0002638_abnormal_pupillary_reflex2.63909211
22MP0004019_abnormal_vitamin_homeostasis2.33017681
23MP0003191_abnormal_cellular_cholesterol2.27878749
24MP0005551_abnormal_eye_electrophysiolog2.26016667
25MP0002138_abnormal_hepatobiliary_system2.22273246
26MP0002160_abnormal_reproductive_system2.12001585
27MP0002118_abnormal_lipid_homeostasis2.11746465
28MP0000751_myopathy2.11550259
29MP0000609_abnormal_liver_physiology2.07757388
30MP0003868_abnormal_feces_composition1.89281313
31MP0004147_increased_porphyrin_level1.84362389
32MP0005319_abnormal_enzyme/_coenzyme1.81316712
33MP0001502_abnormal_circadian_rhythm1.78341126
34MP0001764_abnormal_homeostasis1.68604268
35MP0000538_abnormal_urinary_bladder1.65071151
36MP0005253_abnormal_eye_physiology1.60662932
37MP0005584_abnormal_enzyme/coenzyme_acti1.57871148
38MP0005410_abnormal_fertilization1.56225931
39MP0003646_muscle_fatigue1.55487290
40MP0005330_cardiomyopathy1.51505342
41MP0002909_abnormal_adrenal_gland1.50552019
42MP0001188_hyperpigmentation1.48682754
43MP0003011_delayed_dark_adaptation1.48088725
44MP0009643_abnormal_urine_homeostasis1.48073428
45MP0009697_abnormal_copulation1.44948896
46MP0004215_abnormal_myocardial_fiber1.43996629
47MP0005451_abnormal_body_composition1.38415753
48MP0000013_abnormal_adipose_tissue1.38235520
49MP0004145_abnormal_muscle_electrophysio1.36039485
50MP0003186_abnormal_redox_activity1.35574671
51MP0004133_heterotaxia1.34647632
52MP0003137_abnormal_impulse_conducting1.34054983
53MP0001905_abnormal_dopamine_level1.32065952
54MP0002938_white_spotting1.27212270
55MP0002735_abnormal_chemical_nociception1.23786993
56MP0003656_abnormal_erythrocyte_physiolo1.18671017
57MP0000750_abnormal_muscle_regeneration1.16713597
58MP0001664_abnormal_digestion1.12264957
59MP0000598_abnormal_liver_morphology1.11484677
60MP0005377_hearing/vestibular/ear_phenot1.10732535
61MP0003878_abnormal_ear_physiology1.10732535
62MP0005636_abnormal_mineral_homeostasis1.08987759
63MP0003705_abnormal_hypodermis_morpholog1.07267578
64MP0002272_abnormal_nervous_system1.04677225
65MP0005084_abnormal_gallbladder_morpholo1.04480506
66MP0005647_abnormal_sex_gland1.03925367
67MP0002254_reproductive_system_inflammat1.01290626
68MP0009764_decreased_sensitivity_to1.01135190
69MP0001970_abnormal_pain_threshold1.00349488
70MP0010368_abnormal_lymphatic_system0.99393735
71MP0001324_abnormal_eye_pigmentation0.96693255
72MP0001984_abnormal_olfaction0.96652901
73MP0005389_reproductive_system_phenotype0.95716646
74MP0005646_abnormal_pituitary_gland0.95015421
75MP0009763_increased_sensitivity_to0.94524055
76MP0005670_abnormal_white_adipose0.93697988
77MP0000604_amyloidosis0.93445785
78MP0005220_abnormal_exocrine_pancreas0.92674774
79MP0009046_muscle_twitch0.91590129
80MP0002876_abnormal_thyroid_physiology0.91586723
81MP0001486_abnormal_startle_reflex0.91281140
82MP0006036_abnormal_mitochondrial_physio0.89031005
83MP0003122_maternal_imprinting0.88865868
84MP0009642_abnormal_blood_homeostasis0.88858050
85MP0006072_abnormal_retinal_apoptosis0.88567244
86MP0001756_abnormal_urination0.87466155
87MP0005408_hypopigmentation0.86788940
88MP0008469_abnormal_protein_level0.86072036
89MP0002078_abnormal_glucose_homeostasis0.84094816
90MP0004142_abnormal_muscle_tone0.81381856
91MP0009745_abnormal_behavioral_response0.80998509
92MP0008789_abnormal_olfactory_epithelium0.79400523
93MP0010386_abnormal_urinary_bladder0.79374721
94MP0001485_abnormal_pinna_reflex0.78817492
95MP0000026_abnormal_inner_ear0.75800373
96MP0006276_abnormal_autonomic_nervous0.75192992
97MP0005376_homeostasis/metabolism_phenot0.75112690
98MP0004130_abnormal_muscle_cell0.73329480
99MP0002557_abnormal_social/conspecific_i0.72962293
100MP0002971_abnormal_brown_adipose0.72724122
101MP0001529_abnormal_vocalization0.72613376
102MP0002734_abnormal_mechanical_nocicepti0.72174069
103MP0005535_abnormal_body_temperature0.71868958
104MP0005334_abnormal_fat_pad0.71767728
105MP0009765_abnormal_xenobiotic_induced0.71383336
106MP0004885_abnormal_endolymph0.70122792
107MP0008775_abnormal_heart_ventricle0.69489354
108MP0004782_abnormal_surfactant_physiolog0.68403199
109MP0000749_muscle_degeneration0.68329830
110MP0002064_seizures0.68327893
111MP0001919_abnormal_reproductive_system0.68024029
112MP0001661_extended_life_span0.67127799
113MP0000631_abnormal_neuroendocrine_gland0.66170913
114MP0002572_abnormal_emotion/affect_behav0.64129643
115MP0002653_abnormal_ependyma_morphology0.63799721
116MP0002136_abnormal_kidney_physiology0.63719851
117MP0000003_abnormal_adipose_tissue0.63697404
118MP0000015_abnormal_ear_pigmentation0.63167548
119MP0000747_muscle_weakness0.62727015
120MP0003690_abnormal_glial_cell0.62567009
121MP0005195_abnormal_posterior_eye0.62525540
122MP0000639_abnormal_adrenal_gland0.61705350
123MP0004043_abnormal_pH_regulation0.61300323
124MP0005448_abnormal_energy_balance0.59166921
125MP0002837_dystrophic_cardiac_calcinosis0.58808398
126MP0002928_abnormal_bile_duct0.58222796
127MP0009053_abnormal_anal_canal0.57323994
128MP0005266_abnormal_metabolism0.54456139
129MP0003638_abnormal_response/metabolism_0.53962159
130MP0003724_increased_susceptibility_to0.52976082
131MP0003329_amyloid_beta_deposits0.51579648
132MP0005666_abnormal_adipose_tissue0.47652355
133MP0005395_other_phenotype0.47320957
134MP0003953_abnormal_hormone_level0.47204875
135MP0006035_abnormal_mitochondrial_morpho0.46272226
136MP0005464_abnormal_platelet_physiology0.45667457
137MP0000230_abnormal_systemic_arterial0.44921400
138MP0003075_altered_response_to0.43988174
139MP0008872_abnormal_physiological_respon0.40751634
140MP0002168_other_aberrant_phenotype0.40562272
141MP0008874_decreased_physiological_sensi0.39961475
142MP0001765_abnormal_ion_homeostasis0.38485643
143MP0009115_abnormal_fat_cell0.38356276
144MP0005167_abnormal_blood-brain_barrier0.37723901
145MP0005166_decreased_susceptibility_to0.37417153
146MP0009384_cardiac_valve_regurgitation0.37171727
147MP0002822_catalepsy0.36694902
148MP0008873_increased_physiological_sensi0.36359022
149MP0005248_abnormal_Harderian_gland0.34920963
150MP0000249_abnormal_blood_vessel0.34568693
151MP0005058_abnormal_lysosome_morphology0.34471788
152MP0002295_abnormal_pulmonary_circulatio0.34389298
153MP0003718_maternal_effect0.32686637
154MP0002796_impaired_skin_barrier0.32674042
155MP0009672_abnormal_birth_weight0.32265546
156MP0001944_abnormal_pancreas_morphology0.32090481
157MP0002135_abnormal_kidney_morphology0.30503839
158MP0003436_decreased_susceptibility_to0.29953583
159MP0002970_abnormal_white_adipose0.29943812
160MP0004883_abnormal_blood_vessel0.29709700
161MP0003959_abnormal_lean_body0.29273057
162MP0001845_abnormal_inflammatory_respons0.29226022
163MP0002060_abnormal_skin_morphology0.28590576
164MP0003300_gastrointestinal_ulcer0.28407490

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.27733042
2Intrahepatic cholestasis (HP:0001406)7.08020435
3Deep venous thrombosis (HP:0002625)6.95082298
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.34372017
5Prolonged partial thromboplastin time (HP:0003645)6.07818468
6Xanthomatosis (HP:0000991)6.01156104
7Hypobetalipoproteinemia (HP:0003563)5.98526494
8Hyperlipoproteinemia (HP:0010980)5.30563800
9Testicular atrophy (HP:0000029)4.94425913
10Complement deficiency (HP:0004431)4.91455202
11Increased hepatocellular lipid droplets (HP:0006565)4.90085591
12Lipid accumulation in hepatocytes (HP:0006561)4.71556715
13Hyperammonemia (HP:0001987)4.62306855
14Rib fusion (HP:0000902)4.56412392
15Hypolipoproteinemia (HP:0010981)4.54183251
16Joint hemorrhage (HP:0005261)4.51980453
17Ketosis (HP:0001946)4.49896528
18Hyperglycinemia (HP:0002154)4.44667101
19Mesangial abnormality (HP:0001966)4.42330535
20Renal Fanconi syndrome (HP:0001994)4.39751156
21Attenuation of retinal blood vessels (HP:0007843)4.38404016
22Hyperglycinuria (HP:0003108)4.29958666
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.28351374
24Hypoglycemic coma (HP:0001325)4.21720061
25Epidermoid cyst (HP:0200040)4.19184856
26Dyschromatopsia (HP:0007641)4.18931739
27Abnormality of the common coagulation pathway (HP:0010990)4.17121652
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.15017310
29Abnormality of glycine metabolism (HP:0010895)4.14314672
30Abnormality of serine family amino acid metabolism (HP:0010894)4.14314672
31Abnormality of sulfur amino acid metabolism (HP:0004339)4.12040932
32Fat malabsorption (HP:0002630)4.08112306
33Abnormality of aspartate family amino acid metabolism (HP:0010899)4.06010483
34Abnormality of methionine metabolism (HP:0010901)4.03575283
35Hypoalphalipoproteinemia (HP:0003233)4.02928967
36Popliteal pterygium (HP:0009756)3.97844579
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.79378459
38Congenital stationary night blindness (HP:0007642)3.70384134
39Abnormality of the intrinsic pathway (HP:0010989)3.68920851
40Increased intramyocellular lipid droplets (HP:0012240)3.63070361
41Decreased central vision (HP:0007663)3.61369943
42Abnormality of fatty-acid metabolism (HP:0004359)3.58476515
43Conjugated hyperbilirubinemia (HP:0002908)3.52971299
44Abnormality of complement system (HP:0005339)3.52822259
45Abnormality of pyrimidine metabolism (HP:0004353)3.52501566
46Ketoacidosis (HP:0001993)3.51131139
47Facial diplegia (HP:0001349)3.48295075
48Increased muscle lipid content (HP:0009058)3.41987984
49Hypercholesterolemia (HP:0003124)3.39235602
50Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37302197
51Aplasia of the musculature (HP:0100854)3.35280686
52Decreased electroretinogram (ERG) amplitude (HP:0000654)3.35092088
53Hyperbilirubinemia (HP:0002904)3.31542618
54Rectovaginal fistula (HP:0000143)3.29440998
55Rectal fistula (HP:0100590)3.29440998
56Exertional dyspnea (HP:0002875)3.21772301
57Akinesia (HP:0002304)3.19845949
58Abnormality of nucleobase metabolism (HP:0010932)3.18271673
59Delayed CNS myelination (HP:0002188)3.14323459
60Fetal akinesia sequence (HP:0001989)3.10069918
61Vaginal fistula (HP:0004320)3.09437583
62Steatorrhea (HP:0002570)3.08307578
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.06333647
64Choroideremia (HP:0001139)3.06112317
65Gout (HP:0001997)3.02305819
66Mitochondrial inheritance (HP:0001427)3.01472356
67Abnormality of purine metabolism (HP:0004352)3.01156726
68Hepatocellular carcinoma (HP:0001402)3.01053361
69Abnormality of serum amino acid levels (HP:0003112)3.00430785
70Metabolic acidosis (HP:0001942)2.93900842
71Amniotic constriction ring (HP:0009775)2.89012444
72Abnormality of placental membranes (HP:0011409)2.89012444
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.83343964
74Dicarboxylic aciduria (HP:0003215)2.83343964
75Chorioretinal atrophy (HP:0000533)2.83126837
76Coronal craniosynostosis (HP:0004440)2.79202772
77Myocardial infarction (HP:0001658)2.78361494
78Myotonia (HP:0002486)2.77241293
79Hypoalbuminemia (HP:0003073)2.76363204
80Abnormal albumin level (HP:0012116)2.76363204
81Hypoglycemic seizures (HP:0002173)2.75121271
82Abnormality of renal resorption (HP:0011038)2.74787371
83Intestinal fistula (HP:0100819)2.71926821
84Lethargy (HP:0001254)2.70496011
85Vascular calcification (HP:0004934)2.66960316
86Spontaneous abortion (HP:0005268)2.66484525
87Skin nodule (HP:0200036)2.64375439
88Systemic lupus erythematosus (HP:0002725)2.63810298
89Increased CSF lactate (HP:0002490)2.61500344
90Bony spicule pigmentary retinopathy (HP:0007737)2.57711515
91Hepatocellular necrosis (HP:0001404)2.57709061
92Aplasia/Hypoplasia involving the musculature (HP:0001460)2.55053884
93Generalized aminoaciduria (HP:0002909)2.51692009
94Hypochromic microcytic anemia (HP:0004840)2.49412592
95Delayed epiphyseal ossification (HP:0002663)2.45780065
96Malnutrition (HP:0004395)2.44806376
97Cerebral edema (HP:0002181)2.42939498
98Mitral stenosis (HP:0001718)2.40098441
99Cardiovascular calcification (HP:0011915)2.39166396
100Abnormal gallbladder morphology (HP:0012437)2.38971278
101Hepatic necrosis (HP:0002605)2.38360838
102Amyloidosis (HP:0011034)2.37925076
103Abnormal urine phosphate concentration (HP:0012599)2.36792131
104Acanthocytosis (HP:0001927)2.36706867
105Respiratory difficulties (HP:0002880)2.36355205
106Irritability (HP:0000737)2.35185385
107Neonatal onset (HP:0003623)2.34356237
108Spastic diplegia (HP:0001264)2.33870502
109Facial hemangioma (HP:0000329)2.32616943
110Type 2 muscle fiber atrophy (HP:0003554)2.30910568
111Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.30666221
112Cholelithiasis (HP:0001081)2.30602555
113Glomerulonephritis (HP:0000099)2.29855567
114Late onset (HP:0003584)2.27795221
115Annular pancreas (HP:0001734)2.26981629
116Hyperinsulinemic hypoglycemia (HP:0000825)2.26536137
117Esophageal varix (HP:0002040)2.26246856
118Poikiloderma (HP:0001029)2.24820754
119Absent thumb (HP:0009777)2.24605964
120Cholecystitis (HP:0001082)2.24217988
121Abnormal gallbladder physiology (HP:0012438)2.24217988
122Molar tooth sign on MRI (HP:0002419)2.23263931
123Abnormality of midbrain morphology (HP:0002418)2.23263931
124Sensorimotor neuropathy (HP:0007141)2.23160584
125Vomiting (HP:0002013)2.22850266
126Pancreatitis (HP:0001733)2.22777423
127Enlarged kidneys (HP:0000105)2.22775418
128Alkalosis (HP:0001948)2.22701302
129Hyperphosphaturia (HP:0003109)2.19632537
130Pancreatic fibrosis (HP:0100732)2.15714113
131Acute encephalopathy (HP:0006846)2.13932030
132Thin bony cortex (HP:0002753)2.12021563
133Hydroxyprolinuria (HP:0003080)2.11935149
134Abnormality of proline metabolism (HP:0010907)2.11935149
135True hermaphroditism (HP:0010459)2.11921795
136Proximal tubulopathy (HP:0000114)2.10792233
137Acute necrotizing encephalopathy (HP:0006965)2.08195850
138Turricephaly (HP:0000262)2.07882353
139Nephronophthisis (HP:0000090)2.06431742
140Neonatal respiratory distress (HP:0002643)2.06024375
141Rickets (HP:0002748)2.05144529
142Brushfield spots (HP:0001088)2.04690386
143Menorrhagia (HP:0000132)2.04535884
144Increased purine levels (HP:0004368)2.04478601
145Hyperuricemia (HP:0002149)2.04478601
146Renal tubular dysfunction (HP:0000124)2.02958632
147Optic disc pallor (HP:0000543)2.01641830
148Pancreatic cysts (HP:0001737)2.00204362
149Recurrent gram-negative bacterial infections (HP:0005420)2.00052225
150Abnormality of the gallbladder (HP:0005264)1.98763539
151Patellar aplasia (HP:0006443)1.98556911
152Abnormal cartilage morphology (HP:0002763)1.97322519
153Opisthotonus (HP:0002179)1.97290801
154Polydipsia (HP:0001959)1.96881123
155Abnormal drinking behavior (HP:0030082)1.96881123
156Ulnar bowing (HP:0003031)1.96373261
157Abnormality of urine glucose concentration (HP:0011016)1.96197751
158Glycosuria (HP:0003076)1.96197751
159Abnormal biliary tract physiology (HP:0012439)1.95472493
160Bile duct proliferation (HP:0001408)1.95472493
161Muscle fiber atrophy (HP:0100295)1.94720829
162Atrioventricular block (HP:0001678)1.93943870
163Pendular nystagmus (HP:0012043)1.93657417
164Renal cortical cysts (HP:0000803)1.93335656
165Hemorrhage of the eye (HP:0011885)1.93147271
166Gingival bleeding (HP:0000225)1.93079492
167Widely patent fontanelles and sutures (HP:0004492)1.92544408
168Symptomatic seizures (HP:0011145)1.91860259
169Abnormal epiphyseal ossification (HP:0010656)1.91148417
170Thrombophlebitis (HP:0004418)1.90898460
171Squamous cell carcinoma (HP:0002860)1.89952458
172Hyperglycemia (HP:0003074)1.88822843
173Zonular cataract (HP:0010920)1.87560845
174Abnormal mitochondria in muscle tissue (HP:0008316)1.86039428
175Abnormal enzyme/coenzyme activity (HP:0012379)1.85816579
176Hypophosphatemic rickets (HP:0004912)1.85711040
177Elevated hepatic transaminases (HP:0002910)1.85420670
178Anteriorly placed anus (HP:0001545)1.82566287
179Aplasia/Hypoplasia of the patella (HP:0006498)1.82428267
180Tachypnea (HP:0002789)1.82269191
181Epiphyseal stippling (HP:0010655)1.80079221
182Methylmalonic aciduria (HP:0012120)1.79579902
183Medial flaring of the eyebrow (HP:0010747)1.78899680
184Diminished movement (HP:0002374)1.78528566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.15859932
2SIK14.33769054
3ERN14.13735609
4FGFR44.10136068
5MUSK3.72140511
6INSRR3.70346659
7ZAK2.93844661
8TLK12.75350776
9TAOK32.66015815
10ADRBK22.54951009
11MST1R2.47100325
12ERBB42.24038446
13MAP4K22.09772534
14ACVR1B2.06473083
15STK161.99479733
16FLT31.95673825
17MAP2K41.91548648
18PKN21.89489304
19BMPR1B1.87699629
20FRK1.85475274
21TRIB31.81404922
22STK391.78320572
23OBSCN1.74394679
24PIK3CG1.73428026
25MAPK111.68154342
26STK38L1.65447195
27PHKG21.57216794
28PHKG11.57216794
29DAPK21.54128670
30NUAK11.49640194
31PDK21.47983254
32ADRBK11.47756987
33PTK61.43990371
34TYK21.43607706
35VRK21.40872792
36TIE11.33236869
37MAPK151.33105506
38LATS11.29491595
39NEK91.28341101
40ABL21.27433622
41PRKAA21.17450792
42VRK11.14227384
43FGFR21.13083737
44PINK11.11298429
45MAP2K31.10446422
46KDR1.08111759
47JAK21.07788129
48EPHA41.06419103
49MAP3K71.04397666
50EPHA31.04051166
51CCNB11.01388266
52MET1.01386690
53MAP3K31.01164293
54TRIM280.99270854
55CAMK1D0.97961292
56TGFBR20.97063853
57JAK10.96034023
58DYRK20.94454818
59PIM20.92257802
60TBK10.90572378
61IRAK30.90104206
62AKT30.88345933
63PAK30.86241632
64EPHB10.86205399
65MAP3K140.86043079
66GRK60.85977599
67MAP3K40.84354667
68RIPK10.84291979
69SGK30.84159075
70CSNK1G30.82565747
71GSK3A0.82091395
72MAPK40.81930706
73MYLK0.79265827
74PRKCZ0.75444013
75ERBB20.74831992
76MAP2K60.74129533
77NME10.73840770
78WNK40.73588904
79WNK30.73566772
80RPS6KA50.73471840
81MAPK130.73147538
82SGK20.71546618
83GRK50.71023433
84PRKD30.70207547
85PRKACG0.70184377
86MAP2K70.69381260
87CSNK1G20.69299013
88MAPK120.68338125
89GRK10.68017972
90MST40.67649336
91CSK0.66664579
92BRSK20.66487390
93PTK20.65543806
94PRKAA10.65209663
95PRKCE0.64207390
96CSNK1A1L0.63999039
97TGFBR10.63712913
98PRKACA0.63237341
99CAMK2G0.61585717
100DYRK1B0.60519212
101SGK2230.60456138
102SGK4940.60456138
103MAP3K110.60087496
104MAPKAPK30.59321866
105BLK0.58154598
106IKBKE0.57973665
107PDK30.57669423
108PDK40.57669423
109CDK60.54512128
110MAP2K10.54438936
111WNK10.54237776
112CAMK10.53331302
113MAP3K100.52536701
114MAP2K20.51700727
115FGFR30.51622170
116PDPK10.51140199
117PKN10.48375023
118MAPKAPK50.48078144
119MAP3K20.48038010
120DYRK30.46743160
121PRKCQ0.45648506
122DAPK30.45584853
123PRKD10.45062645
124MAPK70.44181121
125PLK30.43777986
126CAMK2D0.43340618
127CSNK1G10.43160514
128CAMK2A0.43137896
129STK110.42842990
130IGF1R0.41725427
131PLK10.41506655
132IRAK10.41471751
133PRKG10.41046050
134RET0.40782760
135CASK0.40227260
136BMX0.40181305
137PAK10.39819726
138PIK3CA0.38431346
139CSF1R0.37558372
140PRKCH0.36334670
141CSNK1D0.36084715
142CSNK1A10.34402122
143PLK20.33463392
144PTK2B0.33348545
145MAP3K10.33180146
146ROCK10.32539992
147MAP3K50.32186864
148CAMK1G0.31325265
149PRKCI0.31284129
150NTRK20.30461621
151TAOK20.30349323
152PDGFRA0.29630510
153EPHB20.29100259
154CAMK40.28529248
155BUB10.28342468
156ZAP700.28302827
157MARK10.27691114
158AURKA0.27606536
159PDK10.26116992
160PRKCA0.24835029
161OXSR10.24696362
162EGFR0.23405450
163FER0.22919764
164PRKCG0.22705142
165CDK40.21993564
166MAP3K130.21581685

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.32861600
2Nitrogen metabolism_Homo sapiens_hsa009103.47067315
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37367822
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.16478132
5Arginine biosynthesis_Homo sapiens_hsa002202.90211140
6Tryptophan metabolism_Homo sapiens_hsa003802.71239217
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.64840247
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62782732
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.58133685
10Fatty acid degradation_Homo sapiens_hsa000712.57309456
11Complement and coagulation cascades_Homo sapiens_hsa046102.54839755
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.47603988
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.31493769
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.31144821
15Butanoate metabolism_Homo sapiens_hsa006502.24059842
16Oxidative phosphorylation_Homo sapiens_hsa001902.18451998
17* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14530206
18Propanoate metabolism_Homo sapiens_hsa006402.13080639
19Peroxisome_Homo sapiens_hsa041462.11868105
20* Chemical carcinogenesis_Homo sapiens_hsa052041.91200723
21PPAR signaling pathway_Homo sapiens_hsa033201.91141548
22* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89055990
23Fatty acid metabolism_Homo sapiens_hsa012121.88492417
24Histidine metabolism_Homo sapiens_hsa003401.87371123
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.85499272
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.82820136
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76457985
28beta-Alanine metabolism_Homo sapiens_hsa004101.73632025
29Caffeine metabolism_Homo sapiens_hsa002321.72999481
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.69948045
31Retinol metabolism_Homo sapiens_hsa008301.66202387
32Parkinsons disease_Homo sapiens_hsa050121.65244696
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64143375
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62568348
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62003912
36Staphylococcus aureus infection_Homo sapiens_hsa051501.57197210
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55973526
38Selenocompound metabolism_Homo sapiens_hsa004501.55955993
39Phenylalanine metabolism_Homo sapiens_hsa003601.54545975
40Sulfur metabolism_Homo sapiens_hsa009201.50876005
41Bile secretion_Homo sapiens_hsa049761.50693136
42Pyruvate metabolism_Homo sapiens_hsa006201.46174661
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42446828
44Tyrosine metabolism_Homo sapiens_hsa003501.39194061
45Fatty acid elongation_Homo sapiens_hsa000621.34690468
46Starch and sucrose metabolism_Homo sapiens_hsa005001.32969966
47Folate biosynthesis_Homo sapiens_hsa007901.25539336
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.23607381
49Huntingtons disease_Homo sapiens_hsa050161.23478990
50Fat digestion and absorption_Homo sapiens_hsa049751.22908983
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21897162
52Steroid biosynthesis_Homo sapiens_hsa001001.21656181
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.20566617
54ABC transporters_Homo sapiens_hsa020101.18398747
55RNA polymerase_Homo sapiens_hsa030201.17004450
56Carbon metabolism_Homo sapiens_hsa012001.16869604
57Alzheimers disease_Homo sapiens_hsa050101.16572020
58Phototransduction_Homo sapiens_hsa047441.15214751
59Biosynthesis of amino acids_Homo sapiens_hsa012301.14622835
60Sphingolipid metabolism_Homo sapiens_hsa006001.14408894
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12643894
62Cardiac muscle contraction_Homo sapiens_hsa042601.10491947
63Circadian rhythm_Homo sapiens_hsa047101.07481980
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05745016
65Nicotine addiction_Homo sapiens_hsa050331.05007989
66Cyanoamino acid metabolism_Homo sapiens_hsa004601.03622788
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01496315
68Arginine and proline metabolism_Homo sapiens_hsa003301.00772313
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95976409
70Vitamin digestion and absorption_Homo sapiens_hsa049770.94887785
71Taste transduction_Homo sapiens_hsa047420.93401584
72Sulfur relay system_Homo sapiens_hsa041220.91363990
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87984650
74Vitamin B6 metabolism_Homo sapiens_hsa007500.84353835
75Lysine degradation_Homo sapiens_hsa003100.80143119
76Ether lipid metabolism_Homo sapiens_hsa005650.79052203
77Glycerolipid metabolism_Homo sapiens_hsa005610.75205246
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71556458
79Fanconi anemia pathway_Homo sapiens_hsa034600.69939475
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69226897
81* Glutathione metabolism_Homo sapiens_hsa004800.67911245
82Cocaine addiction_Homo sapiens_hsa050300.62056055
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59848994
84One carbon pool by folate_Homo sapiens_hsa006700.59808739
85Pentose phosphate pathway_Homo sapiens_hsa000300.59667529
86Basal transcription factors_Homo sapiens_hsa030220.59221425
87Fatty acid biosynthesis_Homo sapiens_hsa000610.58406680
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57806212
89Hedgehog signaling pathway_Homo sapiens_hsa043400.56526249
90Insulin secretion_Homo sapiens_hsa049110.56345226
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55350879
92Protein export_Homo sapiens_hsa030600.55262111
93Ribosome_Homo sapiens_hsa030100.53438224
94Calcium signaling pathway_Homo sapiens_hsa040200.52025398
95Purine metabolism_Homo sapiens_hsa002300.51470191
96Metabolic pathways_Homo sapiens_hsa011000.47553927
97N-Glycan biosynthesis_Homo sapiens_hsa005100.44504710
98GABAergic synapse_Homo sapiens_hsa047270.40010860
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39120812
100Glutamatergic synapse_Homo sapiens_hsa047240.37854585
101Galactose metabolism_Homo sapiens_hsa000520.33073510
102Fructose and mannose metabolism_Homo sapiens_hsa000510.31519859
103Prion diseases_Homo sapiens_hsa050200.28366568
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27003540
105Insulin resistance_Homo sapiens_hsa049310.25900888
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.24474440
107Linoleic acid metabolism_Homo sapiens_hsa005910.21996239
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14864040
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.13405380
110Glucagon signaling pathway_Homo sapiens_hsa049220.10587731
111AMPK signaling pathway_Homo sapiens_hsa041520.04601277
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03038610
113Lysosome_Homo sapiens_hsa04142-0.2219313
114Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2160837
115Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2114038
116Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1745086
117Hepatitis C_Homo sapiens_hsa05160-0.1722143
118African trypanosomiasis_Homo sapiens_hsa05143-0.1657159
119Mineral absorption_Homo sapiens_hsa04978-0.1619009
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1598490
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1489002
122Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1436983
123Protein digestion and absorption_Homo sapiens_hsa04974-0.1118507
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1007146
125Regulation of autophagy_Homo sapiens_hsa04140-0.0941864
126Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0927640
127Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0875219
128Insulin signaling pathway_Homo sapiens_hsa04910-0.0840451
129Renin-angiotensin system_Homo sapiens_hsa04614-0.0779682
130Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0775377
131Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0631023
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0392243

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