ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	4.38656316
2	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	4.29687617
3	protein retention in ER lumen (GO:0006621)	4.23954644
4	skin morphogenesis (GO:0043589)	4.08245551
5	COPI coating of Golgi vesicle (GO:0048205)	3.96973692
6	Golgi transport vesicle coating (GO:0048200)	3.96973692
7	fibrinolysis (GO:0042730)	3.85880656
8	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.80600357
9	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.72544715
10	L-phenylalanine metabolic process (GO:0006558)	3.72544715
11	protein maturation by protein folding (GO:0022417)	3.59084040
12	negative regulation of fibrinolysis (GO:0051918)	3.40411998
13	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	3.34529642
14	type B pancreatic cell proliferation (GO:0044342)	3.31756007
15	cellular response to cadmium ion (GO:0071276)	3.22597542
16	protein carboxylation (GO:0018214)	3.18549383
17	peptidyl-glutamic acid carboxylation (GO:0017187)	3.18549383
18	regulation of fibrinolysis (GO:0051917)	3.10905431
19	urea metabolic process (GO:0019627)	3.10222255
20	regulation of plasminogen activation (GO:0010755)	3.08357966
21	cell adhesion mediated by integrin (GO:0033627)	3.05477017
22	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.03812201
23	regulation of integrin-mediated signaling pathway (GO:2001044)	3.02191969
24	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.99064240
25	L-phenylalanine catabolic process (GO:0006559)	2.99064240
26	urea cycle (GO:0000050)	2.93456107
27	regulation of mitotic spindle organization (GO:0060236)	2.93056464
28	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.92082299
29	desmosome organization (GO:0002934)	2.89208455
30	lipopolysaccharide biosynthetic process (GO:0009103)	2.88186830
31	bile acid biosynthetic process (GO:0006699)	2.85375262
32	glomerular visceral epithelial cell development (GO:0072015)	2.85203100
33	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	2.82510156
34	atrioventricular valve morphogenesis (GO:0003181)	2.81420239
35	negative regulation of coagulation (GO:0050819)	2.81299641
36	glyoxylate metabolic process (GO:0046487)	2.80592704
37	phosphate ion transmembrane transport (GO:0035435)	2.79903447
38	chondrocyte proliferation (GO:0035988)	2.76281482
39	carnitine metabolic process (GO:0009437)	2.76258809
40	cellular response to zinc ion (GO:0071294)	2.74071701
41	kidney mesenchyme development (GO:0072074)	2.74010952
42	tricarboxylic acid cycle (GO:0006099)	2.73230481
43	endothelial cell morphogenesis (GO:0001886)	2.72610827
44	membrane raft organization (GO:0031579)	2.71128444
45	amino-acid betaine metabolic process (GO:0006577)	2.70960044
46	galactose catabolic process (GO:0019388)	2.70051235
47	glomerular basement membrane development (GO:0032836)	2.67334319
48	NADH metabolic process (GO:0006734)	2.67260836
49	negative regulation of lipase activity (GO:0060192)	2.65740600
50	metanephric mesenchyme development (GO:0072075)	2.65011576
51	basement membrane organization (GO:0071711)	2.64927697
52	endocardial cushion development (GO:0003197)	2.63722063
53	protein hydroxylation (GO:0018126)	2.57200776
54	nitrogen cycle metabolic process (GO:0071941)	2.55536909
55	negative regulation of hemostasis (GO:1900047)	2.54844102
56	negative regulation of blood coagulation (GO:0030195)	2.54844102
57	mitotic nuclear envelope reassembly (GO:0007084)	2.53653995
58	nuclear envelope reassembly (GO:0031468)	2.53653995
59	negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)	2.53532350
60	biotin metabolic process (GO:0006768)	2.52661795
61	positive regulation of extracellular matrix organization (GO:1903055)	2.52020085
62	cellular response to gonadotropin stimulus (GO:0071371)	2.51605669
63	peptidyl-proline hydroxylation (GO:0019511)	2.48420708
64	actin filament depolymerization (GO:0030042)	2.46865624
65	4-hydroxyproline metabolic process (GO:0019471)	2.46152928
66	proteasome assembly (GO:0043248)	2.43382662
67	positive regulation of male gonad development (GO:2000020)	2.42770916
68	regulation of protein activation cascade (GO:2000257)	2.40668631
69	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.40550187
70	negative regulation of wound healing (GO:0061045)	2.39927406
71	glutamine family amino acid biosynthetic process (GO:0009084)	2.38351617
72	protein heterotetramerization (GO:0051290)	2.37500956
73	glomerular epithelial cell development (GO:0072310)	2.37460568
74	regulation of cholesterol homeostasis (GO:2000188)	2.36881389
75	C21-steroid hormone biosynthetic process (GO:0006700)	2.35572702
76	extracellular fibril organization (GO:0043206)	2.35413872
77	regulation of cholesterol biosynthetic process (GO:0045540)	2.34892486
78	gap junction assembly (GO:0016264)	2.34219393
79	response to follicle-stimulating hormone (GO:0032354)	2.34058233
80	xenobiotic catabolic process (GO:0042178)	2.33870599
81	branching involved in salivary gland morphogenesis (GO:0060445)	2.32789038
82	purine nucleotide transport (GO:0015865)	2.32242992
83	regulation of metalloenzyme activity (GO:0048552)	2.30869268
84	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	2.28938683
85	diaphragm development (GO:0060539)	2.27047360
86	positive regulation of actin filament depolymerization (GO:0030836)	2.26746737
87	midgut development (GO:0007494)	2.25115159
88	regulation of bile acid biosynthetic process (GO:0070857)	2.24490299
89	regulation of cardioblast differentiation (GO:0051890)	2.23713714
90	negative regulation of complement activation (GO:0045916)	2.23180769
91	regulation of complement activation (GO:0030449)	2.21407410
92	bile acid metabolic process (GO:0008206)	2.21130727
93	phosphate ion transport (GO:0006817)	2.21045910
94	barbed-end actin filament capping (GO:0051016)	2.18900228
95	regulation of water loss via skin (GO:0033561)	2.18879060
96	galactose metabolic process (GO:0006012)	2.18673416
97	sulfur amino acid catabolic process (GO:0000098)	2.18335928
98	cofactor catabolic process (GO:0051187)	2.18089087
99	muscle cell migration (GO:0014812)	2.17609535
100	COPII vesicle coating (GO:0048208)	2.16808067

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	4.40768575
2	TRIM28_21343339_ChIP-Seq_HEK293_Human	4.07870441
3	RARG_19884340_ChIP-ChIP_MEFs_Mouse	3.94564664
4	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.60552641
5	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.37729220
6	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.91514504
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.78010589
8	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.76227612
9	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.65653195
10	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.56519417
11	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.47672942
12	CLOCK_20551151_ChIP-Seq_293T_Human	2.34823863
13	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.32326660
14	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.22641371
15	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.11477276
16	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.05128948
17	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.96788617
18	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.95156150
19	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.92242849
20	ZNF263_19887448_ChIP-Seq_K562_Human	1.83106322
21	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.82987110
22	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.81809273
23	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.81523808
24	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.79151951
25	ATF3_27146783_Chip-Seq_COLON_Human	1.76691227
26	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.74731657
27	RACK7_27058665_Chip-Seq_MCF-7_Human	1.74362521
28	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.74234475
29	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.74234475
30	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.71374008
31	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.70367289
32	AR_21909140_ChIP-Seq_LNCAP_Human	1.69987968
33	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.63109854
34	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.60836398
35	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.58563421
36	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.57717020
37	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.57155449
38	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.55226700
39	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.54300736
40	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.53629474
41	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.49592574
42	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.43752501
43	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.41404734
44	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.40587150
45	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.39431672
46	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.39065278
47	LXR_22292898_ChIP-Seq_THP-1_Human	1.38401381
48	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.37410576
49	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.37206253
50	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.35942210
51	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.33808422
52	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.33505768
53	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.32833724
54	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.32104276
55	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.30394755
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.29931030
57	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.29582191
58	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.28431258
59	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.27465350
60	SOX2_20726797_ChIP-Seq_SW620_Human	1.23713550
61	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.23044998
62	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.21095792
63	EOMES_21245162_ChIP-Seq_HESCs_Human	1.20762355
64	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.19560390
65	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.16326082
66	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.16038666
67	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.15725888
68	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.15235209
69	CJUN_26792858_Chip-Seq_BT549_Human	1.14549048
70	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.14096334
71	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.13411289
72	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.12411909
73	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.11317976
74	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.09899039
75	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.06561440
76	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06216238
77	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.06062931
78	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.06062931
79	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.06024908
80	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.05396431
81	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.03875255
82	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.03762689
83	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.02613390
84	SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.00935245
85	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.00752924
86	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.98471744
87	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.97586587
88	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.97165425
89	BRD4_25478319_ChIP-Seq_HGPS_Human	0.95829622
90	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.95771610
91	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.94815366
92	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.94384927
93	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.94354638
94	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.94108207
95	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.93611500
96	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.92770706
97	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.92109908
98	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.91254120
99	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.90810398
100	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.90737058

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	4.46837523
2	MP0003705_abnormal_hypodermis_morpholog	3.62103786
3	MP0004272_abnormal_basement_membrane	3.02894238
4	MP0010030_abnormal_orbit_morphology	2.97501795
5	MP0005360_urolithiasis	2.84226976
6	MP0003950_abnormal_plasma_membrane	2.69805798
7	MP0003566_abnormal_cell_adhesion	2.62333495
8	MP0010234_abnormal_vibrissa_follicle	2.51013016
9	MP0005257_abnormal_intraocular_pressure	2.49469982
10	MP0010368_abnormal_lymphatic_system	2.46639747
11	MP0003941_abnormal_skin_development	2.44007429
12	MP0009780_abnormal_chondrocyte_physiolo	2.40133424
13	MP0002139_abnormal_hepatobiliary_system	2.36190853
14	MP0005275_abnormal_skin_tensile	2.30078679
15	MP0009384_cardiac_valve_regurgitation	2.28657963
16	MP0009697_abnormal_copulation	2.26225435
17	MP0005365_abnormal_bile_salt	2.22813151
18	MP0003806_abnormal_nucleotide_metabolis	2.10375462
19	MP0008875_abnormal_xenobiotic_pharmacok	1.98198752
20	MP0004233_abnormal_muscle_weight	1.92624276
21	MP0005623_abnormal_meninges_morphology	1.90520451
22	MP0005058_abnormal_lysosome_morphology	1.87153850
23	MP0000751_myopathy	1.86331767
24	MP0009053_abnormal_anal_canal	1.85651181
25	MP0005085_abnormal_gallbladder_physiolo	1.83552420
26	MP0001661_extended_life_span	1.73061141
27	MP0000762_abnormal_tongue_morphology	1.62631951
28	MP0003191_abnormal_cellular_cholesterol	1.61992386
29	MP0003868_abnormal_feces_composition	1.58546227
30	MP0005023_abnormal_wound_healing	1.52865125
31	MP0000749_muscle_degeneration	1.44771399
32	MP0002060_abnormal_skin_morphology	1.44608601
33	MP0003186_abnormal_redox_activity	1.42762101
34	MP0003279_aneurysm	1.37562382
35	MP0002295_abnormal_pulmonary_circulatio	1.35123830
36	MP0001849_ear_inflammation	1.34860684
37	MP0004858_abnormal_nervous_system	1.33556120
38	MP0010352_gastrointestinal_tract_polyps	1.31562735
39	MP0002796_impaired_skin_barrier	1.29800979
40	MP0002254_reproductive_system_inflammat	1.28166506
41	MP0003091_abnormal_cell_migration	1.27871282
42	MP0001299_abnormal_eye_distance/	1.26195395
43	MP0009840_abnormal_foam_cell	1.25684394
44	MP0000767_abnormal_smooth_muscle	1.23852542
45	MP0000003_abnormal_adipose_tissue	1.21590002
46	MP0002877_abnormal_melanocyte_morpholog	1.20922681
47	MP0010386_abnormal_urinary_bladder	1.20659270
48	MP0005330_cardiomyopathy	1.15716556
49	MP0001542_abnormal_bone_strength	1.15427074
50	MP0005197_abnormal_uvea_morphology	1.14191144
51	MP0006138_congestive_heart_failure	1.11806952
52	MP0005501_abnormal_skin_physiology	1.11595055
53	MP0000013_abnormal_adipose_tissue	1.08787904
54	MP0001243_abnormal_dermal_layer	1.05060003
55	MP0005503_abnormal_tendon_morphology	1.03676223
56	MP0000750_abnormal_muscle_regeneration	0.98638789
57	MP0005165_increased_susceptibility_to	0.97651260
58	MP0002896_abnormal_bone_mineralization	0.95629022
59	MP0003315_abnormal_perineum_morphology	0.95569144
60	MP0001346_abnormal_lacrimal_gland	0.93896489
61	MP0001853_heart_inflammation	0.93409685
62	MP0001666_abnormal_nutrient_absorption	0.93264303
63	MP0005332_abnormal_amino_acid	0.93152283
64	MP0001958_emphysema	0.92333203
65	MP0000467_abnormal_esophagus_morphology	0.91667008
66	MP0010329_abnormal_lipoprotein_level	0.90979574
67	MP0005375_adipose_tissue_phenotype	0.87971612
68	MP0001915_intracranial_hemorrhage	0.87916955
69	MP0004185_abnormal_adipocyte_glucose	0.87664247
70	MP0005508_abnormal_skeleton_morphology	0.87364914
71	MP0000639_abnormal_adrenal_gland	0.86701417
72	MP0000733_abnormal_muscle_development	0.86447702
73	MP0000759_abnormal_skeletal_muscle	0.85557390
74	MP0003942_abnormal_urinary_system	0.85291647
75	MP0003453_abnormal_keratinocyte_physiol	0.85280354
76	MP0005670_abnormal_white_adipose	0.83236806
77	MP0005666_abnormal_adipose_tissue	0.83050567
78	MP0003075_altered_response_to	0.82661982
79	MP0010771_integument_phenotype	0.81471112
80	MP0002269_muscular_atrophy	0.79826077
81	MP0003011_delayed_dark_adaptation	0.75886999
82	MP0009250_abnormal_appendicular_skeleto	0.74570194
83	MP0000579_abnormal_nail_morphology	0.74449297
84	MP0003115_abnormal_respiratory_system	0.72702781
85	MP0005595_abnormal_vascular_smooth	0.72535891
86	MP0004087_abnormal_muscle_fiber	0.72299004
87	MP0005451_abnormal_body_composition	0.72100424
88	MP0001879_abnormal_lymphatic_vessel	0.71989282
89	MP0002168_other_aberrant_phenotype	0.71589811
90	MP0002972_abnormal_cardiac_muscle	0.70479157
91	MP0005584_abnormal_enzyme/coenzyme_acti	0.69845147
92	MP0000538_abnormal_urinary_bladder	0.69379941
93	MP0001340_abnormal_eyelid_morphology	0.68123721
94	MP0001216_abnormal_epidermal_layer	0.67276813
95	MP0005164_abnormal_response_to	0.66163104
96	MP0002108_abnormal_muscle_morphology	0.66106308
97	MP0002282_abnormal_trachea_morphology	0.64941400
98	MP0000747_muscle_weakness	0.63553988
99	MP0000534_abnormal_ureter_morphology	0.63361825
100	MP0003634_abnormal_glial_cell	0.62776263

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature rupture of membranes (HP:0001788)	4.80964008
2	Vertebral compression fractures (HP:0002953)	4.27194194
3	Protrusio acetabuli (HP:0003179)	4.04216641
4	Deep venous thrombosis (HP:0002625)	3.38994802
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.24613182
6	Vascular calcification (HP:0004934)	3.10289379
7	Abnormality of dentin (HP:0010299)	3.08740931
8	Cardiovascular calcification (HP:0011915)	3.08410924
9	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.07639275
10	Distal lower limb muscle weakness (HP:0009053)	3.01599215
11	Achilles tendon contracture (HP:0001771)	3.00095475
12	Cholecystitis (HP:0001082)	2.98975549
13	Abnormal gallbladder physiology (HP:0012438)	2.98975549
14	Abnormality of the Achilles tendon (HP:0005109)	2.91284083
15	Short nail (HP:0001799)	2.83728544
16	Upper limb amyotrophy (HP:0009129)	2.76150298
17	Distal upper limb amyotrophy (HP:0007149)	2.76150298
18	Cervical subluxation (HP:0003308)	2.73458614
19	Hypokinesia (HP:0002375)	2.72172525
20	Mesangial abnormality (HP:0001966)	2.70484110
21	Increased serum pyruvate (HP:0003542)	2.52828668
22	Hand muscle atrophy (HP:0009130)	2.52150015
23	Abnormality of glycolysis (HP:0004366)	2.48605826
24	Intrahepatic cholestasis (HP:0001406)	2.35048238
25	Gonadal dysgenesis (HP:0000133)	2.34301884
26	Mitral stenosis (HP:0001718)	2.34081316
27	Prolonged partial thromboplastin time (HP:0003645)	2.32413719
28	Upper motor neuron abnormality (HP:0002127)	2.23977622
29	Hypoplastic left heart (HP:0004383)	2.21149039
30	Ankle contracture (HP:0006466)	2.19927733
31	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.19730494
32	Osteolytic defects of the hand bones (HP:0009699)	2.19730494
33	Spinal rigidity (HP:0003306)	2.19130848
34	Abnormality of the distal phalanges of the toes (HP:0010182)	2.18609504
35	Generalized amyotrophy (HP:0003700)	2.17066839
36	Blue sclerae (HP:0000592)	2.16593696
37	Reduced subcutaneous adipose tissue (HP:0003758)	2.14986192
38	Entropion (HP:0000621)	2.14312767
39	Shallow orbits (HP:0000586)	2.09076785
40	Follicular hyperkeratosis (HP:0007502)	2.07624134
41	Nemaline bodies (HP:0003798)	2.07291205
42	Increased connective tissue (HP:0009025)	2.05446681
43	Type 1 muscle fiber predominance (HP:0003803)	2.03312793
44	Wormian bones (HP:0002645)	2.00090886
45	Mucopolysacchariduria (HP:0008155)	1.98777057
46	Urinary glycosaminoglycan excretion (HP:0003541)	1.98777057
47	Renal duplication (HP:0000075)	1.97902684
48	Distal lower limb amyotrophy (HP:0008944)	1.97420340
49	Trismus (HP:0000211)	1.97142495
50	Acanthosis nigricans (HP:0000956)	1.96839905
51	Elbow flexion contracture (HP:0002987)	1.93585390
52	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.92411654
53	Abnormality of glycolipid metabolism (HP:0010969)	1.92334699
54	Abnormality of liposaccharide metabolism (HP:0010968)	1.92334699
55	Abnormality of glycosphingolipid metabolism (HP:0004343)	1.92334699
56	Biconcave vertebral bodies (HP:0004586)	1.92293823
57	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.91252144
58	Hypoalphalipoproteinemia (HP:0003233)	1.89749152
59	Focal segmental glomerulosclerosis (HP:0000097)	1.88695916
60	Xanthomatosis (HP:0000991)	1.88567174
61	Nuclear cataract (HP:0100018)	1.87252665
62	Abnormality of polysaccharide metabolism (HP:0011012)	1.86591478
63	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.86591478
64	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.86591478
65	Glucose intolerance (HP:0000833)	1.86443299
66	Vascular tortuosity (HP:0004948)	1.86150579
67	Bladder diverticulum (HP:0000015)	1.84416309
68	Abnormality of the intrinsic pathway (HP:0010989)	1.83779051
69	Muscle fiber inclusion bodies (HP:0100299)	1.83407411
70	Atrophic scars (HP:0001075)	1.82128066
71	Mildly elevated creatine phosphokinase (HP:0008180)	1.81851453
72	Testicular neoplasm (HP:0010788)	1.79166492
73	Hyperacusis (HP:0010780)	1.78822789
74	Hypoplastic heart (HP:0001961)	1.78590171
75	Glomerulosclerosis (HP:0000096)	1.78390815
76	Arterial tortuosity (HP:0005116)	1.77014788
77	Spinal cord compression (HP:0002176)	1.76020420
78	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.75762754
79	Congenital ichthyosiform erythroderma (HP:0007431)	1.75503223
80	Right ventricular cardiomyopathy (HP:0011663)	1.75046985
81	Reduced antithrombin III activity (HP:0001976)	1.74435155
82	Sex reversal (HP:0012245)	1.73329149
83	Abnormal sex determination (HP:0012244)	1.73329149
84	Broad metatarsal (HP:0001783)	1.72781196
85	Paraparesis (HP:0002385)	1.71754888
86	Hypolipoproteinemia (HP:0010981)	1.70448543
87	Turricephaly (HP:0000262)	1.68079537
88	Abnormality of the lower motor neuron (HP:0002366)	1.67195657
89	Delayed gross motor development (HP:0002194)	1.65353632
90	Coxa vara (HP:0002812)	1.64879697
91	Abnormality of the vocal cords (HP:0008777)	1.64859190
92	Abnormality of carpal bone ossification (HP:0006257)	1.64243484
93	Decreased subcutaneous fat (HP:0001002)	1.63314879
94	Insomnia (HP:0100785)	1.63122075
95	Fragile skin (HP:0001030)	1.61990769
96	Abnormality of the acetabulum (HP:0003170)	1.61703278
97	Abnormal ventriculo-arterial connection (HP:0011563)	1.61343215
98	Transposition of the great arteries (HP:0001669)	1.61343215
99	Abnormal connection of the cardiac segments (HP:0011545)	1.61343215
100	Abnormal delivery (HP:0001787)	1.59474433

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	3.81421307
2	TESK1	3.38056859
3	LIMK1	3.27952064
4	NME2	2.74966236
5	MET	2.72406503
6	PBK	2.60985800
7	MST1R	2.57953062
8	MAP3K12	2.42719677
9	ARAF	2.42138230
10	LATS2	2.31948639
11	PTK2	2.25306543
12	MYLK	2.20297383
13	NTRK1	2.13410006
14	BUB1	2.10023421
15	PDGFRA	1.97862376
16	LMTK2	1.95098942
17	PAK4	1.83443691
18	MAP3K9	1.79560314
19	VRK2	1.73805677
20	CAMK1D	1.73549135
21	TESK2	1.69187676
22	MAP3K3	1.66245443
23	PDK2	1.66155116
24	ABL2	1.51482063
25	RIPK1	1.50330629
26	NEK1	1.48286017
27	EPHB1	1.47303560
28	MOS	1.41410365
29	PRKD3	1.40498140
30	CAMK1G	1.37299361
31	DDR2	1.31292318
32	EIF2AK1	1.24640015
33	EPHB2	1.24352794
34	ERBB4	1.22915227
35	PNCK	1.21766691
36	ICK	1.15768487
37	WEE1	1.14801604
38	ILK	1.14463227
39	FLT3	1.13581935
40	BRSK1	1.13096285
41	IRAK3	1.10432047
42	NME1	1.09178395
43	PAK6	1.07883069
44	NEK9	1.04947624
45	STK38	1.03831565
46	PHKG1	1.01075373
47	PHKG2	1.01075373
48	TTN	0.92007008
49	EPHA4	0.90925349
50	PIM2	0.90130933
51	DAPK1	0.85702275
52	PAK2	0.83772518
53	TAOK2	0.81910581
54	FER	0.76733019
55	CAMK2G	0.75915928
56	MAPKAPK3	0.73944791
57	SMG1	0.73438982
58	CAMKK2	0.72910376
59	TRIB3	0.70867283
60	PRKD2	0.68961413
61	PAK1	0.67857292
62	GRK5	0.66429071
63	TSSK6	0.66059908
64	STK16	0.65016638
65	CSNK1G1	0.64482376
66	LATS1	0.62572215
67	LRRK2	0.62480119
68	ROCK2	0.61351025
69	CSNK1G3	0.61293236
70	BRAF	0.61152867
71	SIK1	0.60747301
72	AKT2	0.60468095
73	DAPK3	0.59241439
74	BMX	0.58633687
75	BCKDK	0.56560306
76	ERN1	0.52869042
77	ROCK1	0.50000607
78	MAP3K1	0.49950212
79	AURKA	0.49915691
80	CSNK1A1L	0.49495455
81	CDK8	0.49236400
82	PDGFRB	0.45466666
83	CDK7	0.45372635
84	DMPK	0.44066044
85	SCYL2	0.43277254
86	PRKG2	0.40705859
87	GSK3A	0.40069367
88	TGFBR2	0.38189409
89	INSRR	0.36852703
90	KSR2	0.36715980
91	STK10	0.36250911
92	MAP3K2	0.34198719
93	TTK	0.33756122
94	MAP2K1	0.33489657
95	CAMK2D	0.33423701
96	CAMK2B	0.32808537
97	MAP3K8	0.32005509
98	MTOR	0.28744200
99	PTK2B	0.28259694
100	MAPKAPK5	0.25231869

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.97120883
2	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.81769072
3	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.69102871
4	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.32464793
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.31721612
6	Arginine biosynthesis_Homo sapiens_hsa00220	2.17818188
7	Complement and coagulation cascades_Homo sapiens_hsa04610	2.16033626
8	Fatty acid elongation_Homo sapiens_hsa00062	2.09118110
9	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.08616620
10	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.05734779
11	Phenylalanine metabolism_Homo sapiens_hsa00360	2.05521770
12	Sulfur metabolism_Homo sapiens_hsa00920	2.04830078
13	Proteasome_Homo sapiens_hsa03050	2.00877865
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.00052099
15	Pyruvate metabolism_Homo sapiens_hsa00620	1.90715806
16	* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.83100499
17	Other glycan degradation_Homo sapiens_hsa00511	1.78717093
18	Sulfur relay system_Homo sapiens_hsa04122	1.78057938
19	Carbon metabolism_Homo sapiens_hsa01200	1.71752721
20	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.70238691
21	* Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.57041930
22	Galactose metabolism_Homo sapiens_hsa00052	1.53536303
23	Pentose phosphate pathway_Homo sapiens_hsa00030	1.48768763
24	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.44043668
25	Folate biosynthesis_Homo sapiens_hsa00790	1.43962378
26	* Chemical carcinogenesis_Homo sapiens_hsa05204	1.43436529
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.42900227
28	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.37403029
29	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.37193227
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.35029434
31	Arginine and proline metabolism_Homo sapiens_hsa00330	1.34701960
32	PPAR signaling pathway_Homo sapiens_hsa03320	1.33474295
33	Tyrosine metabolism_Homo sapiens_hsa00350	1.33471573
34	* Glutathione metabolism_Homo sapiens_hsa00480	1.31249313
35	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.30639587
36	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.28818957
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.26702691
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.26418364
39	Fatty acid degradation_Homo sapiens_hsa00071	1.22503375
40	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.21927295
41	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.21643831
42	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.19765005
43	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.16781947
44	beta-Alanine metabolism_Homo sapiens_hsa00410	1.16461878
45	Vibrio cholerae infection_Homo sapiens_hsa05110	1.15998695
46	Bile secretion_Homo sapiens_hsa04976	1.12461701
47	ECM-receptor interaction_Homo sapiens_hsa04512	1.07911387
48	Peroxisome_Homo sapiens_hsa04146	1.07385921
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.03625304
50	Histidine metabolism_Homo sapiens_hsa00340	1.01332846
51	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.01160647
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.97828435
53	Retinol metabolism_Homo sapiens_hsa00830	0.92589700
54	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.90802363
55	Prion diseases_Homo sapiens_hsa05020	0.88897831
56	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.88324650
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.87974002
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.86492262
59	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.81693174
60	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.77988179
61	Mineral absorption_Homo sapiens_hsa04978	0.77960837
62	Propanoate metabolism_Homo sapiens_hsa00640	0.76780752
63	Lysine degradation_Homo sapiens_hsa00310	0.74288858
64	Focal adhesion_Homo sapiens_hsa04510	0.71919754
65	Butanoate metabolism_Homo sapiens_hsa00650	0.71450808
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66615996
67	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.63832363
68	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.63281008
69	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.60397992
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.59485484
71	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59393910
72	Metabolic pathways_Homo sapiens_hsa01100	0.59182221
73	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.57512564
74	Proteoglycans in cancer_Homo sapiens_hsa05205	0.56090473
75	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.55865368
76	Lysosome_Homo sapiens_hsa04142	0.50010793
77	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.49092817
78	Adherens junction_Homo sapiens_hsa04520	0.47683126
79	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47607581
80	Glucagon signaling pathway_Homo sapiens_hsa04922	0.46783106
81	Hippo signaling pathway_Homo sapiens_hsa04390	0.44914646
82	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.43896574
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42689441
84	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.42037489
85	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.40717522
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.39694657
87	Caffeine metabolism_Homo sapiens_hsa00232	0.39669558
88	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.39630965
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.38814620
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38601960
91	Pyrimidine metabolism_Homo sapiens_hsa00240	0.37939934
92	Tight junction_Homo sapiens_hsa04530	0.33870853
93	Circadian rhythm_Homo sapiens_hsa04710	0.32693249
94	One carbon pool by folate_Homo sapiens_hsa00670	0.30769162
95	Base excision repair_Homo sapiens_hsa03410	0.26733636
96	Bladder cancer_Homo sapiens_hsa05219	0.26617857
97	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.26023504
98	Amoebiasis_Homo sapiens_hsa05146	0.24536540
99	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.24529116
100	Insulin signaling pathway_Homo sapiens_hsa04910	0.20052161

GSTT2B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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