ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.12805451
2	response to pheromone (GO:0019236)	4.56503270
3	negative regulation of telomere maintenance (GO:0032205)	4.46516006
4	DNA deamination (GO:0045006)	4.17663688
5	fucose catabolic process (GO:0019317)	4.13407215
6	L-fucose metabolic process (GO:0042354)	4.13407215
7	L-fucose catabolic process (GO:0042355)	4.13407215
8	cellular ketone body metabolic process (GO:0046950)	3.82335434
9	kynurenine metabolic process (GO:0070189)	3.72275428
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.69603649
11	indole-containing compound catabolic process (GO:0042436)	3.64342352
12	indolalkylamine catabolic process (GO:0046218)	3.64342352
13	tryptophan catabolic process (GO:0006569)	3.64342352
14	protein polyglutamylation (GO:0018095)	3.64220719
15	indolalkylamine metabolic process (GO:0006586)	3.63813702
16	ketone body metabolic process (GO:1902224)	3.46566552
17	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.40006224
18	detection of light stimulus involved in visual perception (GO:0050908)	3.36275414
19	detection of light stimulus involved in sensory perception (GO:0050962)	3.36275414
20	piRNA metabolic process (GO:0034587)	3.32590811
21	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.26779493
22	regulation of hexokinase activity (GO:1903299)	3.21574784
23	regulation of glucokinase activity (GO:0033131)	3.21574784
24	platelet dense granule organization (GO:0060155)	3.19371354
25	tryptophan metabolic process (GO:0006568)	3.19162597
26	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.16868927
27	sulfation (GO:0051923)	3.11519182
28	multicellular organism reproduction (GO:0032504)	3.11150480
29	sperm motility (GO:0030317)	3.10627916
30	neuronal action potential (GO:0019228)	3.06438493
31	protein complex biogenesis (GO:0070271)	2.99674081
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.99342488
33	NADH dehydrogenase complex assembly (GO:0010257)	2.99342488
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.99342488
35	rRNA catabolic process (GO:0016075)	2.99097929
36	gamma-aminobutyric acid transport (GO:0015812)	2.97053599
37	epithelial cilium movement (GO:0003351)	2.95507826
38	cytidine deamination (GO:0009972)	2.92372306
39	cytidine metabolic process (GO:0046087)	2.92372306
40	cytidine catabolic process (GO:0006216)	2.92372306
41	regulation of action potential (GO:0098900)	2.91190645
42	male meiosis I (GO:0007141)	2.90759136
43	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.90107823
44	regulation of telomere maintenance (GO:0032204)	2.88770062
45	protein neddylation (GO:0045116)	2.86606974
46	regulation of cilium movement (GO:0003352)	2.86009997
47	indole-containing compound metabolic process (GO:0042430)	2.85744208
48	kidney morphogenesis (GO:0060993)	2.85452356
49	reflex (GO:0060004)	2.81990019
50	nephron epithelium morphogenesis (GO:0072088)	2.80811569
51	nephron tubule morphogenesis (GO:0072078)	2.80811569
52	negative regulation of mast cell activation (GO:0033004)	2.80769693
53	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.76991795
54	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.76930787
55	preassembly of GPI anchor in ER membrane (GO:0016254)	2.76850645
56	mitochondrial respiratory chain complex assembly (GO:0033108)	2.76245115
57	behavioral response to ethanol (GO:0048149)	2.74992444
58	axoneme assembly (GO:0035082)	2.73800386
59	neural tube formation (GO:0001841)	2.72567125
60	rhodopsin mediated signaling pathway (GO:0016056)	2.70341425
61	primary amino compound metabolic process (GO:1901160)	2.68047484
62	DNA methylation involved in gamete generation (GO:0043046)	2.66792688
63	photoreceptor cell development (GO:0042461)	2.66739527
64	exogenous drug catabolic process (GO:0042738)	2.66683683
65	cornea development in camera-type eye (GO:0061303)	2.66668386
66	startle response (GO:0001964)	2.65836304
67	cellular biogenic amine catabolic process (GO:0042402)	2.63673491
68	amine catabolic process (GO:0009310)	2.63673491
69	protein-cofactor linkage (GO:0018065)	2.63186914
70	respiratory chain complex IV assembly (GO:0008535)	2.60149125
71	synaptic transmission, cholinergic (GO:0007271)	2.58611584
72	protein K6-linked ubiquitination (GO:0085020)	2.58386071
73	cilium movement (GO:0003341)	2.55708984
74	amino acid salvage (GO:0043102)	2.53486174
75	L-methionine salvage (GO:0071267)	2.53486174
76	L-methionine biosynthetic process (GO:0071265)	2.53486174
77	rRNA modification (GO:0000154)	2.53054742
78	regulation of memory T cell differentiation (GO:0043380)	2.52460144
79	acrosome reaction (GO:0007340)	2.51903779
80	rRNA methylation (GO:0031167)	2.51834669
81	nonmotile primary cilium assembly (GO:0035058)	2.51265785
82	adaptation of signaling pathway (GO:0023058)	2.50996705
83	glycerophospholipid catabolic process (GO:0046475)	2.50922944
84	serotonin metabolic process (GO:0042428)	2.50550553
85	adenosine metabolic process (GO:0046085)	2.49444960
86	male meiosis (GO:0007140)	2.49405196
87	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.48777264
88	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.47889841
89	cilium morphogenesis (GO:0060271)	2.47847219
90	endoderm formation (GO:0001706)	2.47821626
91	ubiquinone biosynthetic process (GO:0006744)	2.46678935
92	cilium or flagellum-dependent cell motility (GO:0001539)	2.46404531
93	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.45989946
94	negative regulation of multicellular organism growth (GO:0040015)	2.45601451
95	positive regulation of guanylate cyclase activity (GO:0031284)	2.45083971
96	somite rostral/caudal axis specification (GO:0032525)	2.45039104
97	DNA double-strand break processing (GO:0000729)	2.44808477
98	mannosylation (GO:0097502)	2.44255015
99	nucleobase catabolic process (GO:0046113)	2.43942415
100	drug catabolic process (GO:0042737)	2.43145210

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.56871968
2	VDR_22108803_ChIP-Seq_LS180_Human	3.27164481
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.15473370
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.09375743
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.76351399
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47006725
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.37624481
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.29842936
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29083547
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.27651468
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.26505444
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.21526283
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.19685444
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18632826
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05332890
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.03817565
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.02591435
18	FUS_26573619_Chip-Seq_HEK293_Human	1.99809674
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.94903551
20	P300_19829295_ChIP-Seq_ESCs_Human	1.91586207
21	EWS_26573619_Chip-Seq_HEK293_Human	1.86605729
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.79625785
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71299718
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70983228
25	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.70853533
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.69959547
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.66830032
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.65689629
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.65689629
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.62296441
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55171698
32	AR_25329375_ChIP-Seq_VCAP_Human	1.53264889
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.51156862
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.50391739
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.50224079
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48329254
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.46510607
38	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.44498573
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.43979803
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43350272
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42391505
42	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.42010946
43	REST_21632747_ChIP-Seq_MESCs_Mouse	1.41302257
44	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.40332510
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.40166986
46	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38769332
47	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.38426197
48	STAT3_23295773_ChIP-Seq_U87_Human	1.38193461
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37910802
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37910802
51	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35242821
52	TCF4_23295773_ChIP-Seq_U87_Human	1.35080259
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.34217066
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.33503340
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.33503340
56	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.32774598
57	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31775780
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.29640401
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29535527
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.26643073
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26039670
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25688452
63	NCOR_22424771_ChIP-Seq_293T_Human	1.24681646
64	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24612080
65	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.24612080
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23394549
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22871940
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21939824
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20520336
70	AR_20517297_ChIP-Seq_VCAP_Human	1.19409382
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19293060
72	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.18144263
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17784444
74	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16392786
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15579595
76	AR_21572438_ChIP-Seq_LNCaP_Human	1.12744139
77	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.12198467
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12046001
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10904603
80	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.09913945
81	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06890363
82	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.05827933
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.04188668
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.03199824
85	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.02332124
86	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02111010
87	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.02079632
88	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01396417
89	CDX2_22108803_ChIP-Seq_LS180_Human	1.01382981
90	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01212025
91	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.01105260
92	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99205079
93	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98908065
94	ERA_21632823_ChIP-Seq_H3396_Human	0.98697782
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98542528
96	* MYC_19829295_ChIP-Seq_ESCs_Human	0.98168463
97	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.97849157
98	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.96245476
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95874737
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95638734

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.08819006
2	MP0003195_calcinosis	2.98498693
3	MP0001968_abnormal_touch/_nociception	2.68564338
4	MP0005551_abnormal_eye_electrophysiolog	2.50204723
5	MP0002102_abnormal_ear_morphology	2.44645601
6	MP0002837_dystrophic_cardiac_calcinosis	2.40244786
7	MP0002736_abnormal_nociception_after	2.37293729
8	MP0003646_muscle_fatigue	2.35663920
9	MP0003011_delayed_dark_adaptation	2.23187419
10	MP0005645_abnormal_hypothalamus_physiol	2.15118743
11	MP0002876_abnormal_thyroid_physiology	2.07963586
12	MP0006072_abnormal_retinal_apoptosis	2.04160633
13	MP0004133_heterotaxia	1.95205559
14	MP0003880_abnormal_central_pattern	1.93586727
15	MP0005410_abnormal_fertilization	1.92695355
16	MP0005253_abnormal_eye_physiology	1.91108417
17	MP0004147_increased_porphyrin_level	1.90085626
18	MP0008872_abnormal_physiological_respon	1.90010141
19	MP0009046_muscle_twitch	1.89414174
20	MP0009745_abnormal_behavioral_response	1.89217006
21	MP0001986_abnormal_taste_sensitivity	1.87231743
22	MP0002138_abnormal_hepatobiliary_system	1.82427559
23	MP0005646_abnormal_pituitary_gland	1.77454781
24	MP0002272_abnormal_nervous_system	1.76951711
25	MP0000569_abnormal_digit_pigmentation	1.73014914
26	MP0003787_abnormal_imprinting	1.71954105
27	MP0006292_abnormal_olfactory_placode	1.66416251
28	MP0001501_abnormal_sleep_pattern	1.65820971
29	MP0000372_irregular_coat_pigmentation	1.63157530
30	MP0003252_abnormal_bile_duct	1.59901013
31	MP0004885_abnormal_endolymph	1.58172328
32	MP0006276_abnormal_autonomic_nervous	1.55842074
33	MP0005084_abnormal_gallbladder_morpholo	1.51640690
34	MP0002938_white_spotting	1.50887355
35	MP0004043_abnormal_pH_regulation	1.46678645
36	MP0001485_abnormal_pinna_reflex	1.46379081
37	MP0000427_abnormal_hair_cycle	1.45163748
38	MP0002638_abnormal_pupillary_reflex	1.45033375
39	MP0005379_endocrine/exocrine_gland_phen	1.44852520
40	MP0004142_abnormal_muscle_tone	1.43287453
41	MP0001486_abnormal_startle_reflex	1.40000312
42	MP0002163_abnormal_gland_morphology	1.37103596
43	MP0003283_abnormal_digestive_organ	1.34620321
44	MP0005389_reproductive_system_phenotype	1.34599843
45	MP0002160_abnormal_reproductive_system	1.33547215
46	MP0008875_abnormal_xenobiotic_pharmacok	1.32981324
47	MP0002064_seizures	1.27938353
48	MP0003718_maternal_effect	1.26577671
49	MP0000631_abnormal_neuroendocrine_gland	1.26254202
50	MP0002735_abnormal_chemical_nociception	1.26239774
51	MP0002928_abnormal_bile_duct	1.25546019
52	MP0004145_abnormal_muscle_electrophysio	1.23491597
53	MP0003136_yellow_coat_color	1.23365773
54	MP0002572_abnormal_emotion/affect_behav	1.21160619
55	MP0002557_abnormal_social/conspecific_i	1.18051147
56	MP0004742_abnormal_vestibular_system	1.12265065
57	MP0002733_abnormal_thermal_nociception	1.11159264
58	MP0002067_abnormal_sensory_capabilities	1.10260223
59	MP0001919_abnormal_reproductive_system	1.05752915
60	MP0001984_abnormal_olfaction	1.05175787
61	MP0008995_early_reproductive_senescence	1.03704529
62	MP0003698_abnormal_male_reproductive	1.03571001
63	MP0005195_abnormal_posterior_eye	1.03133938
64	MP0001970_abnormal_pain_threshold	1.03069475
65	MP0005386_behavior/neurological_phenoty	1.01042726
66	MP0004924_abnormal_behavior	1.01042726
67	MP0001905_abnormal_dopamine_level	1.00907170
68	MP0002234_abnormal_pharynx_morphology	1.00444001
69	MP0003890_abnormal_embryonic-extraembry	0.98748604
70	MP0002693_abnormal_pancreas_physiology	0.97527594
71	MP0005167_abnormal_blood-brain_barrier	0.96830690
72	MP0003119_abnormal_digestive_system	0.95691311
73	MP0003635_abnormal_synaptic_transmissio	0.94195891
74	MP0002734_abnormal_mechanical_nocicepti	0.91087816
75	MP0001929_abnormal_gametogenesis	0.90778837
76	MP0005085_abnormal_gallbladder_physiolo	0.90579534
77	MP0001764_abnormal_homeostasis	0.90539483
78	MP0002063_abnormal_learning/memory/cond	0.89920051
79	MP0002254_reproductive_system_inflammat	0.88876096
80	MP0002751_abnormal_autonomic_nervous	0.88135853
81	MP0003121_genomic_imprinting	0.86821439
82	MP0002139_abnormal_hepatobiliary_system	0.86391122
83	MP0002277_abnormal_respiratory_mucosa	0.86328103
84	MP0000230_abnormal_systemic_arterial	0.85486955
85	MP0005332_abnormal_amino_acid	0.85233686
86	MP0005174_abnormal_tail_pigmentation	0.85084818
87	MP0002210_abnormal_sex_determination	0.84297737
88	MP0002752_abnormal_somatic_nervous	0.81873599
89	MP0000049_abnormal_middle_ear	0.81558115
90	MP0005075_abnormal_melanosome_morpholog	0.81358774
91	MP0001963_abnormal_hearing_physiology	0.80178454
92	MP0004215_abnormal_myocardial_fiber	0.80036134
93	MP0000026_abnormal_inner_ear	0.79396348
94	MP0008775_abnormal_heart_ventricle	0.77879284
95	MP0003878_abnormal_ear_physiology	0.77680000
96	MP0005377_hearing/vestibular/ear_phenot	0.77680000
97	MP0005423_abnormal_somatic_nervous	0.77454689
98	MP0001440_abnormal_grooming_behavior	0.76870860
99	MP0002653_abnormal_ependyma_morphology	0.76345327
100	MP0001529_abnormal_vocalization	0.75650558

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.42554593
2	True hermaphroditism (HP:0010459)	4.25208427
3	Pancreatic fibrosis (HP:0100732)	4.11511103
4	Congenital stationary night blindness (HP:0007642)	3.98377429
5	Abnormality of midbrain morphology (HP:0002418)	3.78858555
6	Molar tooth sign on MRI (HP:0002419)	3.78858555
7	Nephronophthisis (HP:0000090)	3.47984524
8	Pendular nystagmus (HP:0012043)	3.44796132
9	Chronic hepatic failure (HP:0100626)	3.23473114
10	Progressive cerebellar ataxia (HP:0002073)	3.22576701
11	Abnormality of the renal cortex (HP:0011035)	3.18411152
12	Cystic liver disease (HP:0006706)	3.14245684
13	Hyperventilation (HP:0002883)	3.02392666
14	Attenuation of retinal blood vessels (HP:0007843)	2.94177252
15	Abnormality of the renal medulla (HP:0100957)	2.93179841
16	Abnormal rod and cone electroretinograms (HP:0008323)	2.88303304
17	Type II lissencephaly (HP:0007260)	2.81119599
18	Keratoconus (HP:0000563)	2.77681194
19	Increased corneal curvature (HP:0100692)	2.77681194
20	Abnormality of the labia minora (HP:0012880)	2.74055154
21	Genetic anticipation (HP:0003743)	2.72710085
22	Abolished electroretinogram (ERG) (HP:0000550)	2.70653199
23	Renal cortical cysts (HP:0000803)	2.68477103
24	Decreased central vision (HP:0007663)	2.68075770
25	Tubular atrophy (HP:0000092)	2.54480191
26	Medial flaring of the eyebrow (HP:0010747)	2.53537940
27	Sclerocornea (HP:0000647)	2.43482990
28	Gaze-evoked nystagmus (HP:0000640)	2.43446337
29	Polydipsia (HP:0001959)	2.43417657
30	Abnormal drinking behavior (HP:0030082)	2.43417657
31	Hypothermia (HP:0002045)	2.42200654
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.35839182
33	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.34453855
34	Methylmalonic acidemia (HP:0002912)	2.27530665
35	Hypoplasia of the fovea (HP:0007750)	2.24358764
36	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.24358764
37	Mitochondrial inheritance (HP:0001427)	2.24297889
38	Congenital, generalized hypertrichosis (HP:0004540)	2.23822611
39	Anencephaly (HP:0002323)	2.22987950
40	Inability to walk (HP:0002540)	2.22187744
41	Acute necrotizing encephalopathy (HP:0006965)	2.20971829
42	Male pseudohermaphroditism (HP:0000037)	2.18057565
43	Furrowed tongue (HP:0000221)	2.17878216
44	Optic nerve hypoplasia (HP:0000609)	2.17512927
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.16050548
46	Congenital hepatic fibrosis (HP:0002612)	2.11754649
47	3-Methylglutaconic aciduria (HP:0003535)	2.11068721
48	Increased CSF lactate (HP:0002490)	2.10227886
49	Febrile seizures (HP:0002373)	2.06980038
50	Absent/shortened dynein arms (HP:0200106)	2.05785123
51	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.05785123
52	Large for gestational age (HP:0001520)	2.03881993
53	Progressive inability to walk (HP:0002505)	2.03360182
54	Severe visual impairment (HP:0001141)	2.02865150
55	Progressive macrocephaly (HP:0004481)	2.02384115
56	Optic disc pallor (HP:0000543)	2.02351442
57	Prostate neoplasm (HP:0100787)	2.02109097
58	Abnormal biliary tract physiology (HP:0012439)	2.02043951
59	Bile duct proliferation (HP:0001408)	2.02043951
60	Abnormality of the fovea (HP:0000493)	2.00509429
61	Methylmalonic aciduria (HP:0012120)	2.00251044
62	Hemiparesis (HP:0001269)	1.98766694
63	Acute encephalopathy (HP:0006846)	1.98397767
64	Cerebellar dysplasia (HP:0007033)	1.98237999
65	Focal seizures (HP:0007359)	1.97961950
66	Severe muscular hypotonia (HP:0006829)	1.97786908
67	Bony spicule pigmentary retinopathy (HP:0007737)	1.97174930
68	Hyperalaninemia (HP:0003348)	1.95910292
69	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95910292
70	Abnormality of alanine metabolism (HP:0010916)	1.95910292
71	Polyuria (HP:0000103)	1.94895725
72	Gait imbalance (HP:0002141)	1.94828134
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.93549269
74	Hepatic necrosis (HP:0002605)	1.91195906
75	Lissencephaly (HP:0001339)	1.90952625
76	Chorioretinal atrophy (HP:0000533)	1.90147020
77	Hypoalbuminemia (HP:0003073)	1.89764670
78	Abnormal albumin level (HP:0012116)	1.89764670
79	Small hand (HP:0200055)	1.89249056
80	Postaxial foot polydactyly (HP:0001830)	1.88699500
81	Broad-based gait (HP:0002136)	1.88574128
82	Intestinal atresia (HP:0011100)	1.88208309
83	Concave nail (HP:0001598)	1.87002382
84	Congenital primary aphakia (HP:0007707)	1.86742659
85	Hyperglycinemia (HP:0002154)	1.86020451
86	Ketosis (HP:0001946)	1.84687803
87	Abnormality of urine glucose concentration (HP:0011016)	1.83227049
88	Glycosuria (HP:0003076)	1.83227049
89	Nephrogenic diabetes insipidus (HP:0009806)	1.80813394
90	Abnormal respiratory epithelium morphology (HP:0012253)	1.80610601
91	Abnormal respiratory motile cilium morphology (HP:0005938)	1.80610601
92	Congenital sensorineural hearing impairment (HP:0008527)	1.80519355
93	Genital tract atresia (HP:0001827)	1.80003484
94	Gastrointestinal atresia (HP:0002589)	1.79230275
95	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.79021987
96	Hepatocellular necrosis (HP:0001404)	1.78257445
97	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77970826
98	Abnormal mitochondria in muscle tissue (HP:0008316)	1.76189001
99	Abnormality of the pons (HP:0007361)	1.75486961
100	Hyperglycinuria (HP:0003108)	1.75357546

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.27121685
2	TLK1	3.38893567
3	ADRBK2	3.16955147
4	MAP4K2	2.96222032
5	GRK1	2.95107206
6	BMPR1B	2.83655218
7	ZAK	2.67998231
8	WNK3	2.62695147
9	PINK1	2.52896758
10	WNK4	2.48939760
11	ACVR1B	2.20945263
12	TXK	2.06060668
13	INSRR	2.01534588
14	NUAK1	1.98921017
15	CASK	1.97083598
16	OXSR1	1.94749030
17	MAPK13	1.92137201
18	PNCK	1.39405364
19	TAOK3	1.39036455
20	STK39	1.37646182
21	TNIK	1.31281898
22	DAPK2	1.29622688
23	MKNK2	1.23099649
24	DYRK2	1.19007518
25	NTRK3	1.14815946
26	PAK3	1.14456994
27	BRSK2	1.11820010
28	MAP3K4	1.09665320
29	BCKDK	1.09503752
30	VRK1	1.05478774
31	PLK4	0.99786993
32	PRKCG	0.99248702
33	MAP2K6	0.98593248
34	MARK1	0.90922844
35	PLK2	0.90582239
36	STK38L	0.90416931
37	ADRBK1	0.89735191
38	PRKCE	0.88571740
39	TRIM28	0.87332661
40	MUSK	0.86963234
41	FGFR2	0.85602423
42	MST4	0.83484724
43	MAPK15	0.80594415
44	TIE1	0.79179507
45	PTK2B	0.79039011
46	VRK2	0.77232333
47	CAMKK2	0.76702386
48	CSNK1G2	0.75894591
49	PHKG2	0.72887015
50	PHKG1	0.72887015
51	MAPKAPK3	0.72644392
52	BCR	0.72199744
53	SIK2	0.72097176
54	STK16	0.70416909
55	MAP2K7	0.69230597
56	MKNK1	0.68476511
57	CSNK1G3	0.67808739
58	CSNK1G1	0.66282819
59	TAF1	0.65593024
60	MAPKAPK5	0.64933820
61	WEE1	0.64191226
62	CDK19	0.61253744
63	TGFBR1	0.58984606
64	PKN1	0.58131133
65	PIK3CA	0.57429583
66	CAMK2A	0.57391208
67	PRKCQ	0.57242433
68	TEC	0.57101536
69	PLK3	0.54792526
70	IKBKB	0.54414307
71	NME1	0.51198671
72	FER	0.50429695
73	ITK	0.48597418
74	CAMK1	0.48142084
75	PRKACA	0.47970334
76	RPS6KA5	0.47305501
77	GRK6	0.46592940
78	CSNK1A1L	0.45997925
79	EPHA4	0.45152758
80	STK11	0.43783716
81	EIF2AK3	0.41086717
82	PRKAA2	0.40908102
83	PRKCZ	0.40182252
84	NTRK2	0.39396147
85	GRK7	0.38923925
86	ERBB3	0.36796803
87	PRKCA	0.36528139
88	PRKAA1	0.35752088
89	CSNK1A1	0.34702436
90	IRAK1	0.32645033
91	CAMK2D	0.31095189
92	AKT3	0.30864737
93	STK3	0.30837519
94	MAP3K7	0.30187836
95	PRKG1	0.28644717
96	PLK1	0.28558620
97	CSNK1D	0.28427966
98	PRKCI	0.27405425
99	BUB1	0.26858555
100	MINK1	0.26804104

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.08884034
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.70455303
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.64308705
4	Protein export_Homo sapiens_hsa03060	2.50985305
5	Butanoate metabolism_Homo sapiens_hsa00650	2.40033621
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.39640628
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.33347348
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.26516773
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.11226893
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.95564113
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.89646834
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.86608884
13	Caffeine metabolism_Homo sapiens_hsa00232	1.84140775
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.81232757
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.81221760
16	Nicotine addiction_Homo sapiens_hsa05033	1.80616669
17	RNA polymerase_Homo sapiens_hsa03020	1.80547247
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.80470011
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.80393570
20	Homologous recombination_Homo sapiens_hsa03440	1.78189336
21	Parkinsons disease_Homo sapiens_hsa05012	1.75826649
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.75376797
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.75165570
24	Olfactory transduction_Homo sapiens_hsa04740	1.72873834
25	Propanoate metabolism_Homo sapiens_hsa00640	1.58265297
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.55560586
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51933804
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.47090387
29	Taste transduction_Homo sapiens_hsa04742	1.33808889
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.24973645
31	Retinol metabolism_Homo sapiens_hsa00830	1.24548298
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.22333331
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.21729114
34	ABC transporters_Homo sapiens_hsa02010	1.20700865
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.20584199
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.20275420
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17260860
38	Peroxisome_Homo sapiens_hsa04146	1.15865861
39	Insulin secretion_Homo sapiens_hsa04911	1.11445736
40	Type I diabetes mellitus_Homo sapiens_hsa04940	1.11350969
41	Alzheimers disease_Homo sapiens_hsa05010	1.11277810
42	Morphine addiction_Homo sapiens_hsa05032	1.09153737
43	Huntingtons disease_Homo sapiens_hsa05016	1.08599164
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06507201
45	Basal transcription factors_Homo sapiens_hsa03022	1.04844467
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.00484193
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00106424
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.97691321
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93598523
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.92628874
51	RNA degradation_Homo sapiens_hsa03018	0.89907804
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.89517449
53	Primary immunodeficiency_Homo sapiens_hsa05340	0.85271198
54	Asthma_Homo sapiens_hsa05310	0.82267812
55	Glutamatergic synapse_Homo sapiens_hsa04724	0.82243716
56	Regulation of autophagy_Homo sapiens_hsa04140	0.82097345
57	Proteasome_Homo sapiens_hsa03050	0.82000177
58	GABAergic synapse_Homo sapiens_hsa04727	0.81749383
59	Serotonergic synapse_Homo sapiens_hsa04726	0.80278013
60	Sulfur metabolism_Homo sapiens_hsa00920	0.78217498
61	Mineral absorption_Homo sapiens_hsa04978	0.77938303
62	Fatty acid elongation_Homo sapiens_hsa00062	0.77380593
63	Circadian entrainment_Homo sapiens_hsa04713	0.76350480
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.74797004
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74228815
66	Purine metabolism_Homo sapiens_hsa00230	0.72969476
67	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.71964918
68	Allograft rejection_Homo sapiens_hsa05330	0.71725061
69	Graft-versus-host disease_Homo sapiens_hsa05332	0.69617338
70	One carbon pool by folate_Homo sapiens_hsa00670	0.67621690
71	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.67587184
72	Histidine metabolism_Homo sapiens_hsa00340	0.67006153
73	Salivary secretion_Homo sapiens_hsa04970	0.66854345
74	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.66159987
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65705324
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65660553
77	Metabolic pathways_Homo sapiens_hsa01100	0.61644565
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.61385479
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60582635
80	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60478899
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57647813
82	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.57226803
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.55057502
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.54476515
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.51871023
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.51639774
87	Fatty acid degradation_Homo sapiens_hsa00071	0.51090656
88	Circadian rhythm_Homo sapiens_hsa04710	0.50595695
89	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.49772326
90	Cocaine addiction_Homo sapiens_hsa05030	0.47160538
91	Fatty acid metabolism_Homo sapiens_hsa01212	0.47110897
92	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.45623467
93	Steroid biosynthesis_Homo sapiens_hsa00100	0.43752526
94	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.40502149
95	Non-homologous end-joining_Homo sapiens_hsa03450	0.38229196
96	Amphetamine addiction_Homo sapiens_hsa05031	0.37209810
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36477422
98	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33959452
99	Long-term depression_Homo sapiens_hsa04730	0.31963968
100	Rheumatoid arthritis_Homo sapiens_hsa05323	0.31935429

GSTTP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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