GSTZ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme catalyzes the conversion of maleylacetoacetate to fumarylacetoacatate, which is one of the steps in the phenylalanine/tyrosine degradation pathway. Deficiency of a similar gene in mouse causes oxidative stress. Several transcript variants of this gene encode multiple protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.18199244
2* L-phenylalanine catabolic process (GO:0006559)7.18199244
3* erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.82249510
4* L-phenylalanine metabolic process (GO:0006558)6.82249510
5* aromatic amino acid family catabolic process (GO:0009074)6.37496636
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.97224838
7indole-containing compound catabolic process (GO:0042436)5.74846322
8indolalkylamine catabolic process (GO:0046218)5.74846322
9tryptophan catabolic process (GO:0006569)5.74846322
10alpha-linolenic acid metabolic process (GO:0036109)5.62469641
11glyoxylate metabolic process (GO:0046487)5.60680631
12kynurenine metabolic process (GO:0070189)5.55736098
13bile acid biosynthetic process (GO:0006699)5.54931272
14tryptophan metabolic process (GO:0006568)5.45662616
15sulfur amino acid catabolic process (GO:0000098)5.32693001
16cysteine metabolic process (GO:0006534)5.28300534
17urea metabolic process (GO:0019627)5.23045487
18urea cycle (GO:0000050)5.23045487
19complement activation, alternative pathway (GO:0006957)5.11576414
20high-density lipoprotein particle remodeling (GO:0034375)5.06331066
21negative regulation of fibrinolysis (GO:0051918)5.03936532
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.00150534
23peptidyl-glutamic acid carboxylation (GO:0017187)4.93030106
24protein carboxylation (GO:0018214)4.93030106
25serine family amino acid catabolic process (GO:0009071)4.88525093
26regulation of fibrinolysis (GO:0051917)4.85286316
27nitrogen cycle metabolic process (GO:0071941)4.83792639
28regulation of protein activation cascade (GO:2000257)4.83347194
29bile acid metabolic process (GO:0008206)4.80166260
30lysine catabolic process (GO:0006554)4.76875764
31lysine metabolic process (GO:0006553)4.76875764
32regulation of triglyceride catabolic process (GO:0010896)4.72139118
33homocysteine metabolic process (GO:0050667)4.67088048
34acylglycerol homeostasis (GO:0055090)4.63565865
35triglyceride homeostasis (GO:0070328)4.63565865
36* aromatic amino acid family metabolic process (GO:0009072)4.58487558
37amino-acid betaine metabolic process (GO:0006577)4.58242634
38regulation of complement activation (GO:0030449)4.52818541
39reverse cholesterol transport (GO:0043691)4.49190624
40* alpha-amino acid catabolic process (GO:1901606)4.46729891
41regulation of cholesterol esterification (GO:0010872)4.45848779
42plasma lipoprotein particle remodeling (GO:0034369)4.42544234
43protein-lipid complex remodeling (GO:0034368)4.42544234
44macromolecular complex remodeling (GO:0034367)4.42544234
45cellular ketone body metabolic process (GO:0046950)4.40186485
46plasma lipoprotein particle clearance (GO:0034381)4.38580907
47coenzyme catabolic process (GO:0009109)4.18841196
48protein complex biogenesis (GO:0070271)4.18725314
49* cellular amino acid catabolic process (GO:0009063)4.18405526
50phospholipid efflux (GO:0033700)4.18259820
51indolalkylamine metabolic process (GO:0006586)4.13458096
52negative regulation of sterol transport (GO:0032372)4.13048807
53negative regulation of cholesterol transport (GO:0032375)4.13048807
54* tyrosine metabolic process (GO:0006570)4.12843567
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11027391
56exogenous drug catabolic process (GO:0042738)4.05749164
57glutamate metabolic process (GO:0006536)4.00525552
58energy coupled proton transport, down electrochemical gradient (GO:0015985)3.99716984
59ATP synthesis coupled proton transport (GO:0015986)3.99716984
60bile acid and bile salt transport (GO:0015721)3.99458562
61glycine metabolic process (GO:0006544)3.99301302
62cellular biogenic amine catabolic process (GO:0042402)3.98904445
63amine catabolic process (GO:0009310)3.98904445
64serine family amino acid metabolic process (GO:0009069)3.98011070
65short-chain fatty acid metabolic process (GO:0046459)3.97463899
66acetyl-CoA metabolic process (GO:0006084)3.97074180
67mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96192861
68ethanol oxidation (GO:0006069)3.95541460
69water-soluble vitamin biosynthetic process (GO:0042364)3.95527225
70cellular modified amino acid catabolic process (GO:0042219)3.94558096
71cellular glucuronidation (GO:0052695)3.92893308
72mitochondrial respiratory chain complex assembly (GO:0033108)3.91969765
73imidazole-containing compound metabolic process (GO:0052803)3.91404431
74benzene-containing compound metabolic process (GO:0042537)3.90097485
75fatty acid beta-oxidation (GO:0006635)3.88014011
76mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.86159137
77mitochondrial respiratory chain complex I assembly (GO:0032981)3.86159137
78NADH dehydrogenase complex assembly (GO:0010257)3.86159137
79cholesterol efflux (GO:0033344)3.84791301
80drug catabolic process (GO:0042737)3.84082434
81fatty acid oxidation (GO:0019395)3.81777693
82* organic acid catabolic process (GO:0016054)3.81019810
83* carboxylic acid catabolic process (GO:0046395)3.81019810
84ketone body metabolic process (GO:1902224)3.80717379
85positive regulation of lipid catabolic process (GO:0050996)3.79157944
86valine metabolic process (GO:0006573)3.78498329
87aldehyde catabolic process (GO:0046185)3.77648544
88establishment of protein localization to mitochondrial membrane (GO:0090151)3.76477678
89lipid oxidation (GO:0034440)3.74550321
90serine family amino acid biosynthetic process (GO:0009070)3.73798731
91monocarboxylic acid catabolic process (GO:0072329)3.72268841
92fatty acid catabolic process (GO:0009062)3.69265865
93positive regulation of fatty acid beta-oxidation (GO:0032000)3.68863925
94dicarboxylic acid biosynthetic process (GO:0043650)3.68737922
95plasma lipoprotein particle assembly (GO:0034377)3.68099607
962-oxoglutarate metabolic process (GO:0006103)3.66720078
97behavioral response to nicotine (GO:0035095)3.66688323
98arginine metabolic process (GO:0006525)3.66593834
99phospholipid homeostasis (GO:0055091)3.65795684
100respiratory chain complex IV assembly (GO:0008535)3.64804734
101negative regulation of lipase activity (GO:0060192)3.64086378
102low-density lipoprotein particle remodeling (GO:0034374)3.63577785
103drug transmembrane transport (GO:0006855)3.59161430
104fibrinolysis (GO:0042730)3.59093635
105positive regulation of triglyceride lipase activity (GO:0061365)3.59073775
106positive regulation of lipoprotein lipase activity (GO:0051006)3.59073775
107oxidative demethylation (GO:0070989)3.58209751
108cholesterol homeostasis (GO:0042632)3.57607090
109regulation of cholesterol homeostasis (GO:2000188)3.55199632
110glucuronate metabolic process (GO:0019585)3.52472934
111uronic acid metabolic process (GO:0006063)3.52472934
112cofactor catabolic process (GO:0051187)3.52405953
113sterol homeostasis (GO:0055092)3.52241085
114electron transport chain (GO:0022900)3.51487405
115aspartate family amino acid catabolic process (GO:0009068)3.50822875
116carnitine metabolic process (GO:0009437)3.50055163
117respiratory electron transport chain (GO:0022904)3.49560426
118cytochrome complex assembly (GO:0017004)3.37035089
119platelet dense granule organization (GO:0060155)3.36019719
120regulation of mitochondrial translation (GO:0070129)3.24900447
121rRNA modification (GO:0000154)3.24673352
122omega-hydroxylase P450 pathway (GO:0097267)3.17756604
123peptidyl-histidine modification (GO:0018202)3.09072771
124protein-cofactor linkage (GO:0018065)3.07056268
125tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.05290818
126RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.05290818
127epoxygenase P450 pathway (GO:0019373)3.04647732
128ribosomal small subunit assembly (GO:0000028)2.98694244
129L-methionine salvage (GO:0071267)2.94304750
130L-methionine biosynthetic process (GO:0071265)2.94304750
131amino acid salvage (GO:0043102)2.94304750
132inner mitochondrial membrane organization (GO:0007007)2.92727782
133base-excision repair, AP site formation (GO:0006285)2.86577622
134rRNA methylation (GO:0031167)2.86315320
135transcription elongation from RNA polymerase III promoter (GO:0006385)2.85478929
136termination of RNA polymerase III transcription (GO:0006386)2.85478929
137mannosylation (GO:0097502)2.84539325
138viral transcription (GO:0019083)2.84265040
139translational termination (GO:0006415)2.82808199
140ATP biosynthetic process (GO:0006754)2.76841785
141purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.75891539
142maturation of 5.8S rRNA (GO:0000460)2.75422981
143branched-chain amino acid catabolic process (GO:0009083)2.75062154
144purine nucleoside triphosphate biosynthetic process (GO:0009145)2.74292308
145GTP biosynthetic process (GO:0006183)2.72882426
146ubiquinone biosynthetic process (GO:0006744)2.72110264
147nucleotide transmembrane transport (GO:1901679)2.68432176
148pseudouridine synthesis (GO:0001522)2.67799244
149chaperone-mediated protein transport (GO:0072321)2.67504286
150L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64879313
151vitamin biosynthetic process (GO:0009110)2.64063660
152regulation of hexokinase activity (GO:1903299)2.62890427
153regulation of glucokinase activity (GO:0033131)2.62890427
154protein neddylation (GO:0045116)2.61609662
155S-adenosylmethionine metabolic process (GO:0046500)2.60964514
156DNA deamination (GO:0045006)2.60352256
157hydrogen ion transmembrane transport (GO:1902600)2.58833553
158xenobiotic catabolic process (GO:0042178)2.57421291
159SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.56273198
160preassembly of GPI anchor in ER membrane (GO:0016254)2.56228314
161ubiquinone metabolic process (GO:0006743)2.54797808
162nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54224305
163proteasome assembly (GO:0043248)2.52256852
164cotranslational protein targeting to membrane (GO:0006613)2.51953201
165endosome to melanosome transport (GO:0035646)2.51853052
166endosome to pigment granule transport (GO:0043485)2.51853052
167intracellular protein transmembrane import (GO:0044743)2.49890506
168drug metabolic process (GO:0017144)2.49577092
169proton transport (GO:0015992)2.49026369
170ribonucleoside triphosphate biosynthetic process (GO:0009201)2.46983657
171protein targeting to ER (GO:0045047)2.46531823
172ribosomal small subunit biogenesis (GO:0042274)2.46232241
173exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45925744
174translational elongation (GO:0006414)2.45522008
175hydrogen transport (GO:0006818)2.45086656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.11956242
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.93842906
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.50233396
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.33810296
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.20163405
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.10183365
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.92319977
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.94336507
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.87065501
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.84355759
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.78555264
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.32358703
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27405873
14EST1_17652178_ChIP-ChIP_JURKAT_Human3.16061997
15ZNF274_21170338_ChIP-Seq_K562_Hela2.98073761
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.73203304
17* ETS1_20019798_ChIP-Seq_JURKAT_Human2.66069406
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63322379
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47424988
20VDR_22108803_ChIP-Seq_LS180_Human2.37743017
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.33419196
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14632539
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06494591
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.04253974
25VDR_23849224_ChIP-Seq_CD4+_Human2.00045041
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3227423
27CLOCK_20551151_ChIP-Seq_293T_Human1.97535208
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93416291
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91777913
30MYC_18940864_ChIP-ChIP_HL60_Human1.81379102
31IRF1_19129219_ChIP-ChIP_H3396_Human1.77336752
32FOXP3_21729870_ChIP-Seq_TREG_Human1.77037194
33IGF1R_20145208_ChIP-Seq_DFB_Human1.76795217
34GATA1_22025678_ChIP-Seq_K562_Human1.72490911
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.68005939
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66389877
37ELK1_19687146_ChIP-ChIP_HELA_Human1.63873507
38GABP_19822575_ChIP-Seq_HepG2_Human1.62537358
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.58855823
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54668391
41* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52390191
42TP53_22573176_ChIP-Seq_HFKS_Human1.51694740
43ER_23166858_ChIP-Seq_MCF-7_Human1.48970312
44* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48285542
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47571381
46HNF4A_19822575_ChIP-Seq_HepG2_Human1.39123478
47TTF2_22483619_ChIP-Seq_HELA_Human1.38263133
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.34452570
49DCP1A_22483619_ChIP-Seq_HELA_Human1.34187488
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33969038
51EWS_26573619_Chip-Seq_HEK293_Human1.33843620
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33156921
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.33156921
54* HTT_18923047_ChIP-ChIP_STHdh_Human1.33066776
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32198244
56* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30765390
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30711977
58XRN2_22483619_ChIP-Seq_HELA_Human1.30580022
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25911738
60ERA_21632823_ChIP-Seq_H3396_Human1.25584023
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24661598
62* KDM5A_27292631_Chip-Seq_BREAST_Human1.24608647
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23706772
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20316026
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19936646
66FUS_26573619_Chip-Seq_HEK293_Human1.19096560
67* HOXB7_26014856_ChIP-Seq_BT474_Human1.18665768
68NCOR_22424771_ChIP-Seq_293T_Human1.17913851
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17845362
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.15143054
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13771337
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12114425
73GBX2_23144817_ChIP-Seq_PC3_Human1.12014103
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11697957
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10699193
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10661462
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10595565
78NANOG_20526341_ChIP-Seq_ESCs_Human1.09078405
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08465778
80ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08361932
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04254717
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03660124
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03426405
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02962598
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02731545
86MYC_19829295_ChIP-Seq_ESCs_Human1.00236821
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98654885
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98544937
89PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97505410
90TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96852769
91ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96552641
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95149208
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94296219
94ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93883376
95RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92813559
96YY1_21170310_ChIP-Seq_MESCs_Mouse0.92092275
97OCT4_20526341_ChIP-Seq_ESCs_Human0.89523821
98FOXP1_21924763_ChIP-Seq_HESCs_Human0.89101910
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89076625
100P300_19829295_ChIP-Seq_ESCs_Human0.88916368
101YY1_22570637_ChIP-Seq_MALME-3M_Human0.88594024
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88489787
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87942470
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87752193
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.87718061
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87672608
107E2F4_17652178_ChIP-ChIP_JURKAT_Human0.87550381
108GATA4_25053715_ChIP-Seq_YYC3_Human0.87298807
109NANOG_19829295_ChIP-Seq_ESCs_Human0.87038611
110SOX2_19829295_ChIP-Seq_ESCs_Human0.87038611
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86851607
112SOX2_16153702_ChIP-ChIP_HESCs_Human0.86842893
113CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86107748
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85634763
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83343444
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82232066
117IRF8_22096565_ChIP-ChIP_GC-B_Human0.81105578
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79732905
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78117435
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71690333
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71690333
122RARA_24833708_ChIP-Seq_LIVER_Mouse0.71325915
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.70645043
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70149005
125KAP1_22055183_ChIP-Seq_ESCs_Mouse0.69705917
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69291607
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.69023338
128PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.68504070
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67989437
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.67541806
131Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.67178923
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66431118
133FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.65279745
134TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.62839861
135RARB_24833708_ChIP-Seq_LIVER_Mouse0.62251975
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.61660727
137AR_20517297_ChIP-Seq_VCAP_Human0.61515621
138ESR1_21235772_ChIP-Seq_MCF-7_Human0.61085697
139PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.60705408
140PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.60404063
141ZNF263_19887448_ChIP-Seq_K562_Human0.60194514
142BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60181239
143CEBPB_22108803_ChIP-Seq_LS180_Human0.58070279
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56905969
145NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.54850401
146FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.53225324
147CBP_21632823_ChIP-Seq_H3396_Human0.52301546
148MYC_19915707_ChIP-ChIP_AK7_Human0.50853829
149LXR_22292898_ChIP-Seq_THP-1_Human0.50805607
150RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.50720935
151ESET_19884257_ChIP-Seq_ESCs_Mouse0.50150421
152GATA1_19941826_ChIP-Seq_K562_Human0.49381249
153STAT1_17558387_ChIP-Seq_HELA_Human0.48361180
154P53_21459846_ChIP-Seq_SAOS-2_Human0.48093318
155PPAR_26484153_Chip-Seq_NCI-H1993_Human0.48059947
156ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.47986645
157FOXO3_23340844_ChIP-Seq_DLD1_Human0.47821847
158BCAT_22108803_ChIP-Seq_LS180_Human0.47367971
159SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47159796
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.47008100
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46781261
162ERG_20517297_ChIP-Seq_VCAP_Human0.46389303
163EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.45913805
164EGR1_19032775_ChIP-ChIP_M12_Human0.44417163
165STAT3_1855785_ChIP-Seq_MESCs_Mouse0.44089325
166SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43045260
167GATA3_24758297_ChIP-Seq_MCF-7_Human0.42890852
168FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42588228
169GATA2_19941826_ChIP-Seq_K562_Human0.42508008
170SOX2_20726797_ChIP-Seq_SW620_Human0.41596491
171TAF2_19829295_ChIP-Seq_ESCs_Human0.41508237
172GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.41118584
173E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.40641387
174GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.40195911
175TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.39766095
176CDX2_20551321_ChIP-Seq_CACO-2_Human0.39099397
177ESR1_20079471_ChIP-ChIP_T-47D_Human0.38568974
178TBX20_22328084_ChIP-Seq_HEART_Mouse0.38177096
179TBX20_22080862_ChIP-Seq_HEART_Mouse0.38177096
180GATA1_19941827_ChIP-Seq_MEL_Mouse0.37450976
181CDX2_22108803_ChIP-Seq_LS180_Human0.37369677
182FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.36970975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.07956512
2MP0005360_urolithiasis7.25042237
3MP0005365_abnormal_bile_salt6.05088203
4MP0005085_abnormal_gallbladder_physiolo5.96393128
5MP0008875_abnormal_xenobiotic_pharmacok4.85479412
6MP0003806_abnormal_nucleotide_metabolis4.05025050
7MP0003252_abnormal_bile_duct3.73358126
8MP0010329_abnormal_lipoprotein_level3.68804676
9MP0003195_calcinosis3.01889970
10MP0009840_abnormal_foam_cell2.95903901
11MP0005332_abnormal_amino_acid2.91066175
12MP0005083_abnormal_biliary_tract2.77699747
13MP0001666_abnormal_nutrient_absorption2.50914130
14MP0003191_abnormal_cellular_cholesterol2.40988659
15MP0003646_muscle_fatigue2.40936265
16MP0002118_abnormal_lipid_homeostasis2.28655430
17MP0004019_abnormal_vitamin_homeostasis2.23264090
18* MP0000609_abnormal_liver_physiology2.16340653
19MP0006292_abnormal_olfactory_placode2.16081612
20MP0003136_yellow_coat_color2.10692913
21MP0003718_maternal_effect2.00189505
22MP0009379_abnormal_foot_pigmentation1.98839860
23MP0002138_abnormal_hepatobiliary_system1.98347175
24MP0002653_abnormal_ependyma_morphology1.96916880
25MP0005670_abnormal_white_adipose1.92001473
26MP0005646_abnormal_pituitary_gland1.88420312
27MP0005551_abnormal_eye_electrophysiolog1.87233878
28MP0005319_abnormal_enzyme/_coenzyme1.85873053
29MP0001764_abnormal_homeostasis1.79655706
30MP0003868_abnormal_feces_composition1.77116666
31MP0000372_irregular_coat_pigmentation1.75305888
32MP0003693_abnormal_embryo_hatching1.71872663
33MP0002938_white_spotting1.70549763
34MP0005584_abnormal_enzyme/coenzyme_acti1.63345510
35MP0002160_abnormal_reproductive_system1.52266741
36MP0002102_abnormal_ear_morphology1.51645893
37* MP0009643_abnormal_urine_homeostasis1.46655118
38MP0006072_abnormal_retinal_apoptosis1.43834392
39MP0009697_abnormal_copulation1.43473373
40MP0008877_abnormal_DNA_methylation1.41143810
41MP0005075_abnormal_melanosome_morpholog1.37929422
42MP0001986_abnormal_taste_sensitivity1.37101377
43MP0002876_abnormal_thyroid_physiology1.34979096
44MP0004142_abnormal_muscle_tone1.33761671
45MP0004145_abnormal_muscle_electrophysio1.32281849
46MP0004133_heterotaxia1.31292268
47MP0005645_abnormal_hypothalamus_physiol1.31191861
48MP0008058_abnormal_DNA_repair1.30056108
49MP0000427_abnormal_hair_cycle1.27866269
50MP0005451_abnormal_body_composition1.27751750
51* MP0003186_abnormal_redox_activity1.26737367
52MP0004130_abnormal_muscle_cell1.24416189
53MP0002163_abnormal_gland_morphology1.24070976
54MP0001293_anophthalmia1.23212660
55MP0001968_abnormal_touch/_nociception1.23187596
56MP0002638_abnormal_pupillary_reflex1.21052835
57* MP0002837_dystrophic_cardiac_calcinosis1.19713071
58MP0003011_delayed_dark_adaptation1.19403421
59MP0005389_reproductive_system_phenotype1.14785034
60MP0003656_abnormal_erythrocyte_physiolo1.13981334
61MP0005666_abnormal_adipose_tissue1.12704878
62* MP0000598_abnormal_liver_morphology1.11873681
63MP0005253_abnormal_eye_physiology1.10907014
64MP0005636_abnormal_mineral_homeostasis1.08383966
65MP0005647_abnormal_sex_gland1.08155081
66MP0002078_abnormal_glucose_homeostasis1.07913861
67MP0002971_abnormal_brown_adipose1.07451361
68MP0005377_hearing/vestibular/ear_phenot1.07182276
69MP0003878_abnormal_ear_physiology1.07182276
70MP0005410_abnormal_fertilization1.06426901
71MP0006036_abnormal_mitochondrial_physio1.06048865
72MP0002736_abnormal_nociception_after1.04618377
73MP0009046_muscle_twitch1.03475041
74MP0003705_abnormal_hypodermis_morpholog1.03304376
75MP0005334_abnormal_fat_pad1.01782548
76MP0001661_extended_life_span1.01573260
77MP0004147_increased_porphyrin_level1.00843771
78MP0005174_abnormal_tail_pigmentation1.00153348
79MP0001485_abnormal_pinna_reflex1.00068063
80MP0005535_abnormal_body_temperature0.97573257
81MP0000604_amyloidosis0.96131285
82MP0009764_decreased_sensitivity_to0.94262462
83MP0002210_abnormal_sex_determination0.94006949
84MP0002254_reproductive_system_inflammat0.92438069
85* MP0009763_increased_sensitivity_to0.91676785
86MP0009642_abnormal_blood_homeostasis0.91616404
87MP0001756_abnormal_urination0.90884340
88MP0003890_abnormal_embryonic-extraembry0.90617907
89MP0005220_abnormal_exocrine_pancreas0.90052978
90MP0000631_abnormal_neuroendocrine_gland0.89967810
91MP0005195_abnormal_posterior_eye0.89868896
92MP0005084_abnormal_gallbladder_morpholo0.89495361
93MP0003119_abnormal_digestive_system0.88882748
94MP0001919_abnormal_reproductive_system0.88404281
95MP0000383_abnormal_hair_follicle0.86958062
96MP0005408_hypopigmentation0.83997097
97MP0002277_abnormal_respiratory_mucosa0.83991940
98MP0008469_abnormal_protein_level0.83633153
99MP0003698_abnormal_male_reproductive0.83319466
100MP0001929_abnormal_gametogenesis0.82514459
101MP0003283_abnormal_digestive_organ0.82461270
102MP0010030_abnormal_orbit_morphology0.80981982
103MP0005376_homeostasis/metabolism_phenot0.80554391
104MP0004043_abnormal_pH_regulation0.80403805
105MP0002095_abnormal_skin_pigmentation0.79850260
106MP0002751_abnormal_autonomic_nervous0.79636387
107MP0002234_abnormal_pharynx_morphology0.79598470
108MP0010368_abnormal_lymphatic_system0.78694024
109MP0001145_abnormal_male_reproductive0.78640584
110MP0000653_abnormal_sex_gland0.78402498
111MP0003690_abnormal_glial_cell0.77971130
112MP0005448_abnormal_energy_balance0.77509108
113MP0003567_abnormal_fetal_cardiomyocyte0.75702761
114MP0000026_abnormal_inner_ear0.75100299
115MP0010094_abnormal_chromosome_stability0.73535216
116MP0001905_abnormal_dopamine_level0.73319222
117MP0001324_abnormal_eye_pigmentation0.72807990
118MP0009765_abnormal_xenobiotic_induced0.72723443
119MP0005266_abnormal_metabolism0.67834940
120MP0005375_adipose_tissue_phenotype0.65882149
121MP0004185_abnormal_adipocyte_glucose0.63820879
122MP0003724_increased_susceptibility_to0.62432553
123MP0009115_abnormal_fat_cell0.62161629
124MP0003953_abnormal_hormone_level0.61460179
125MP0003329_amyloid_beta_deposits0.59437738
126MP0002136_abnormal_kidney_physiology0.58555173
127MP0002970_abnormal_white_adipose0.57942927
128MP0000639_abnormal_adrenal_gland0.57779582
129MP0006035_abnormal_mitochondrial_morpho0.54955172
130MP0004782_abnormal_surfactant_physiolog0.54842023
131MP0002928_abnormal_bile_duct0.54605890
132MP0003959_abnormal_lean_body0.53111308
133MP0000230_abnormal_systemic_arterial0.51403356
134MP0001944_abnormal_pancreas_morphology0.50729425
135MP0005058_abnormal_lysosome_morphology0.50115900
136MP0005395_other_phenotype0.46160162
137MP0009672_abnormal_birth_weight0.45377780
138MP0002168_other_aberrant_phenotype0.44014582
139MP0003638_abnormal_response/metabolism_0.43461962
140MP0000013_abnormal_adipose_tissue0.40593293
141MP0009053_abnormal_anal_canal0.40307242
142MP0001765_abnormal_ion_homeostasis0.39589659
143MP0001881_abnormal_mammary_gland0.37104694
144MP0005452_abnormal_adipose_tissue0.36171668
145MP0008874_decreased_physiological_sensi0.35791749
146MP0005464_abnormal_platelet_physiology0.35456979
147MP0008873_increased_physiological_sensi0.34905236
148MP0002796_impaired_skin_barrier0.34632535
149MP0003075_altered_response_to0.34466606
150MP0004264_abnormal_extraembryonic_tissu0.34415696
151MP0009780_abnormal_chondrocyte_physiolo0.33738358
152MP0008872_abnormal_physiological_respon0.32676192
153MP0000249_abnormal_blood_vessel0.30459741
154MP0000003_abnormal_adipose_tissue0.30421372
155MP0005379_endocrine/exocrine_gland_phen0.30218854
156MP0002060_abnormal_skin_morphology0.30127288
157MP0002822_catalepsy0.29881995
158MP0005248_abnormal_Harderian_gland0.27729361
159MP0002693_abnormal_pancreas_physiology0.26637236
160MP0008438_abnormal_cutaneous_collagen0.26617467

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.16859217
2Intrahepatic cholestasis (HP:0001406)6.65298753
3Deep venous thrombosis (HP:0002625)6.57365007
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.00950062
5Xanthomatosis (HP:0000991)5.99137648
6Prolonged partial thromboplastin time (HP:0003645)5.91038255
7Hypobetalipoproteinemia (HP:0003563)5.72013794
8Hyperlipoproteinemia (HP:0010980)5.31653405
9Complement deficiency (HP:0004431)5.06997564
10Ketosis (HP:0001946)4.67138433
11Hyperammonemia (HP:0001987)4.64239862
12Hyperglycinemia (HP:0002154)4.55416232
13Hypoglycemic coma (HP:0001325)4.53001305
14Hyperglycinuria (HP:0003108)4.51152307
15Hypolipoproteinemia (HP:0010981)4.47375675
16Abnormality of serine family amino acid metabolism (HP:0010894)4.33518033
17Abnormality of glycine metabolism (HP:0010895)4.33518033
18Joint hemorrhage (HP:0005261)4.32004609
19Epidermoid cyst (HP:0200040)4.31835633
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.17385389
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.14424545
22Abnormality of the common coagulation pathway (HP:0010990)4.09551155
23Hypoalphalipoproteinemia (HP:0003233)4.07574660
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.99844881
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.97620136
26Abnormality of methionine metabolism (HP:0010901)3.90704184
27Acute encephalopathy (HP:0006846)3.90435559
28Acute necrotizing encephalopathy (HP:0006965)3.90109498
29Pancreatic cysts (HP:0001737)3.80312881
30Mitochondrial inheritance (HP:0001427)3.78399761
31Ketoacidosis (HP:0001993)3.76713933
32Fat malabsorption (HP:0002630)3.76302586
33Abnormality of fatty-acid metabolism (HP:0004359)3.71654150
34Abnormality of the intrinsic pathway (HP:0010989)3.67492564
35Abnormal mitochondria in muscle tissue (HP:0008316)3.65267106
36Abnormality of complement system (HP:0005339)3.62433311
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.62016404
38Pancreatic fibrosis (HP:0100732)3.58353489
39Conjugated hyperbilirubinemia (HP:0002908)3.52892947
40Increased CSF lactate (HP:0002490)3.52016702
41True hermaphroditism (HP:0010459)3.42875126
42Lipid accumulation in hepatocytes (HP:0006561)3.40791780
43Hepatic necrosis (HP:0002605)3.40664499
44Hypercholesterolemia (HP:0003124)3.40397029
45Hepatocellular necrosis (HP:0001404)3.38718429
46Abnormality of pyrimidine metabolism (HP:0004353)3.31370835
47Hyperbilirubinemia (HP:0002904)3.20878695
48Progressive macrocephaly (HP:0004481)3.14322409
49Increased hepatocellular lipid droplets (HP:0006565)3.13646709
50Abnormality of nucleobase metabolism (HP:0010932)3.13234497
51Hypoglycemic seizures (HP:0002173)3.10687798
52Abnormality of serum amino acid levels (HP:0003112)3.10683016
53Delayed CNS myelination (HP:0002188)3.08682813
54Abnormality of purine metabolism (HP:0004352)3.04166329
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97597747
56Dicarboxylic aciduria (HP:0003215)2.97597747
57Metabolic acidosis (HP:0001942)2.93342770
58Renal Fanconi syndrome (HP:0001994)2.92867141
59Gout (HP:0001997)2.90810063
60Skin nodule (HP:0200036)2.80433934
61Hepatocellular carcinoma (HP:0001402)2.79263838
62Steatorrhea (HP:0002570)2.79023859
63Abnormality of midbrain morphology (HP:0002418)2.79017463
64Molar tooth sign on MRI (HP:0002419)2.79017463
65Lethargy (HP:0001254)2.78981185
66Congenital stationary night blindness (HP:0007642)2.75691246
67Abnormal number of erythroid precursors (HP:0012131)2.75624521
68Myocardial infarction (HP:0001658)2.74830599
69Reticulocytopenia (HP:0001896)2.74671613
70Generalized aminoaciduria (HP:0002909)2.73050084
71Hyperinsulinemic hypoglycemia (HP:0000825)2.62906856
72Increased serum lactate (HP:0002151)2.60525022
73Sclerocornea (HP:0000647)2.58518225
74Cerebral edema (HP:0002181)2.58062346
753-Methylglutaconic aciduria (HP:0003535)2.53231595
76Spontaneous abortion (HP:0005268)2.53012308
77Reduced antithrombin III activity (HP:0001976)2.52831955
78Systemic lupus erythematosus (HP:0002725)2.52320353
79Lactic acidosis (HP:0003128)2.51878479
80Chronic hepatic failure (HP:0100626)2.51603618
81Nephronophthisis (HP:0000090)2.51310300
82Abnormality of cells of the erythroid lineage (HP:0012130)2.51159801
83Methylmalonic aciduria (HP:0012120)2.50604267
84Pendular nystagmus (HP:0012043)2.46666491
85Abnormal biliary tract physiology (HP:0012439)2.44573503
86Bile duct proliferation (HP:0001408)2.44573503
87Late onset (HP:0003584)2.43814298
88Cystic liver disease (HP:0006706)2.42281957
89Irritability (HP:0000737)2.40194137
90Hypochromic microcytic anemia (HP:0004840)2.39486420
91Increased intramyocellular lipid droplets (HP:0012240)2.38804881
92Vascular calcification (HP:0004934)2.38183131
93Abnormal gallbladder morphology (HP:0012437)2.37036042
94Type II lissencephaly (HP:0007260)2.36604931
95Type I transferrin isoform profile (HP:0003642)2.36359034
96Pancreatitis (HP:0001733)2.35845358
97Vomiting (HP:0002013)2.30335883
98Enlarged kidneys (HP:0000105)2.29916003
99Methylmalonic acidemia (HP:0002912)2.29393942
100Abnormality of the renal cortex (HP:0011035)2.27179888
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26067776
102Abnormality of alanine metabolism (HP:0010916)2.26067776
103Hyperalaninemia (HP:0003348)2.26067776
104Spastic diplegia (HP:0001264)2.25619375
105Brushfield spots (HP:0001088)2.24803989
106Cholelithiasis (HP:0001081)2.23473764
107Respiratory failure (HP:0002878)2.21636496
108Increased muscle lipid content (HP:0009058)2.21520604
109Proximal tubulopathy (HP:0000114)2.21198250
110Acanthocytosis (HP:0001927)2.20513280
111Malnutrition (HP:0004395)2.20499059
112Neonatal onset (HP:0003623)2.20465693
113Symptomatic seizures (HP:0011145)2.19349731
114Hyperglycemia (HP:0003074)2.18797137
115Mitral stenosis (HP:0001718)2.18167135
116Medial flaring of the eyebrow (HP:0010747)2.17727501
117Aplasia/Hypoplasia of the tongue (HP:0010295)2.16669947
118Abnormal protein glycosylation (HP:0012346)2.15396817
119Abnormal glycosylation (HP:0012345)2.15396817
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15396817
121Abnormal protein N-linked glycosylation (HP:0012347)2.15396817
122Male pseudohermaphroditism (HP:0000037)2.14668947
123Abnormality of proline metabolism (HP:0010907)2.14548919
124Hydroxyprolinuria (HP:0003080)2.14548919
125Sensorimotor neuropathy (HP:0007141)2.14311133
126Glomerulonephritis (HP:0000099)2.13919136
127Cardiovascular calcification (HP:0011915)2.12046183
128Amyloidosis (HP:0011034)2.11629902
129Optic disc pallor (HP:0000543)2.11339119
130Hyperuricemia (HP:0002149)2.10605159
131Increased purine levels (HP:0004368)2.10605159
132Alkalosis (HP:0001948)2.08081243
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08017530
134Large for gestational age (HP:0001520)2.07714803
135Opisthotonus (HP:0002179)2.07437551
136Renal cortical cysts (HP:0000803)2.06174496
137Cholecystitis (HP:0001082)2.05701704
138Abnormal gallbladder physiology (HP:0012438)2.05701704
139Abnormality of the renal medulla (HP:0100957)2.03910593
140Hemorrhage of the eye (HP:0011885)2.03573695
141Hypertriglyceridemia (HP:0002155)2.02876947
142Furrowed tongue (HP:0000221)2.02645563
143Abnormality of urine glucose concentration (HP:0011016)2.01957210
144Glycosuria (HP:0003076)2.01957210
145Hyperventilation (HP:0002883)2.01704602
146Recurrent gram-negative bacterial infections (HP:0005420)2.01318119
147Congenital hepatic fibrosis (HP:0002612)2.00995070
148Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99781829
149Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99781829
150Anencephaly (HP:0002323)1.99211918
151Severe muscular hypotonia (HP:0006829)1.97621486
152Abnormality of renal resorption (HP:0011038)1.96162858
153Concave nail (HP:0001598)1.96078025
154Abnormal cartilage morphology (HP:0002763)1.94927424
155Abnormality of the gallbladder (HP:0005264)1.92420364
156Esophageal varix (HP:0002040)1.92089074
157Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91140761
158Absent thumb (HP:0009777)1.89820792
159Menorrhagia (HP:0000132)1.89627234
160Rickets (HP:0002748)1.88742093
161Elevated hepatic transaminases (HP:0002910)1.86256276
162Abnormal enzyme/coenzyme activity (HP:0012379)1.85909842
163Tubular atrophy (HP:0000092)1.84833428
164Abnormal rod and cone electroretinograms (HP:0008323)1.83908908
165CNS demyelination (HP:0007305)1.83815203
166Polydipsia (HP:0001959)1.83172655
167Abnormal drinking behavior (HP:0030082)1.83172655
168Gingival bleeding (HP:0000225)1.82958240
169Hyperphosphaturia (HP:0003109)1.82095463
170Chromsome breakage (HP:0040012)1.81618333
171Nausea (HP:0002018)1.81022269
172Exercise intolerance (HP:0003546)1.79517786
173Anophthalmia (HP:0000528)1.79211452
174Abolished electroretinogram (ERG) (HP:0000550)1.76831519
175Hypoplasia of the pons (HP:0012110)1.75191323
176Aplasia/Hypoplasia of the uvula (HP:0010293)1.74650840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.44308526
2SIK14.68415473
3VRK24.51917489
4ERN14.18239190
5INSRR4.08926601
6FGFR43.83150444
7ACVR1B3.46952017
8ZAK3.13643032
9TLK12.91050914
10STK162.68507631
11TAOK32.67625930
12BMPR1B2.48126578
13TRIB32.40435911
14ADRBK22.29885391
15MST1R2.21845357
16VRK12.17892238
17ERBB42.14765759
18FLT32.10086356
19NME22.09626882
20PIK3CG1.99293097
21TAF11.91903623
22FRK1.87386454
23MAP2K41.86855864
24CAMK1D1.83612106
25NUAK11.83194756
26MUSK1.80619173
27PKN21.79305221
28MAPK151.67785351
29STK391.65543170
30MAPK111.63623781
31MST41.54431984
32PHKG21.52349919
33PHKG11.52349919
34BUB11.51640477
35MAP4K21.50654613
36PASK1.47163874
37NME11.45911322
38CDK191.35051913
39PRKAA21.32495487
40LATS11.31274494
41NEK91.29566338
42PTK61.29266669
43FGFR21.28736379
44PINK11.28324640
45MAP2K71.21204374
46MAP3K41.20242570
47STK38L1.19663852
48NEK21.18388489
49LIMK11.18249914
50WNK31.17369763
51TYK21.15186145
52ABL21.14657493
53IRAK31.14134362
54MAPKAPK31.12886555
55DYRK21.11979857
56PDK41.11424777
57PDK31.11424777
58JAK21.10257671
59CAMK1G1.09976396
60WNK41.09245885
61PRKCI1.08315691
62CDC71.05354304
63CASK1.04879806
64MET1.03437827
65DAPK21.02969498
66CSNK1G30.98954351
67RPS6KB20.96343880
68TGFBR10.93916883
69MAP3K30.92063589
70EIF2AK30.91175274
71KDR0.90834917
72NEK10.90090266
73MAP3K70.88944106
74JAK10.88823098
75TIE10.88576374
76PIM20.88199269
77CHEK20.86544803
78MAP2K30.85917682
79PRKAA10.84646995
80PLK40.82873109
81ADRBK10.82139604
82CSNK1G20.81188850
83EPHA20.79749575
84PRKACG0.79138930
85PLK10.78053103
86PRKCZ0.75210040
87GSK3A0.74751710
88ATR0.74064173
89CSNK1A1L0.73192894
90AURKA0.72615502
91ERBB20.71686566
92RPS6KA50.71135730
93IKBKB0.70425494
94CDK60.69178185
95RIPK10.68724577
96MAPK40.68231549
97MAP3K120.67224074
98EPHB10.66043141
99TBK10.65615713
100FGFR30.64706732
101BRSK20.64706309
102SGK30.64224801
103EPHA30.63644601
104DYRK1B0.63406064
105TNK20.63133327
106PBK0.62180267
107PDPK10.62104880
108PRKCE0.60352754
109MAPKAPK50.59164955
110PLK30.58090715
111TRIM280.57570910
112MAP3K140.55988177
113CSK0.55793620
114MAPK120.54738544
115CAMK2G0.54657220
116SGK4940.54242037
117SGK2230.54242037
118MAP2K10.53828191
119TGFBR20.53088421
120CHUK0.52358958
121SGK20.52176792
122PTK20.51985620
123IGF1R0.51020516
124IRAK10.50874879
125CSNK1A10.50874351
126STK30.49344926
127GRK60.48280008
128PIK3CA0.45797364
129TESK10.45436665
130ILK0.44940444
131AURKB0.44831786
132EIF2AK10.44653030
133MAP3K110.44513762
134MAP3K20.44243865
135PDK20.44025416
136MAP2K60.44014010
137EIF2AK20.43523226
138MKNK20.41740262
139CSNK1G10.41310680
140IRAK20.41044571
141TNIK0.40901234
142DAPK30.40418325
143MAPK130.40167298
144CSNK2A10.39484808
145TESK20.38528830
146PAK30.38368800
147MTOR0.37744162
148RET0.37610047
149MAPK70.37389427
150MAP3K60.37370120
151MAP3K100.37098257
152PDK10.36867471
153PRKCQ0.35087105
154CSNK2A20.34868586
155TTK0.34430791
156DAPK10.33718694
157EPHB20.32806247
158MYLK0.31960644
159GRK10.31723860
160OBSCN0.31609399
161STK110.30094570
162PDGFRA0.29722828
163MAP3K10.29088317
164CSF1R0.28801627
165ATM0.28455853
166OXSR10.28078032
167FER0.27574003
168MAP3K50.25860511
169PRKCH0.25644230
170AKT30.23274605
171PRKCA0.23191177
172PRKACA0.22737123
173CDK40.22381610
174LMTK20.21809734
175PRKCG0.21753242

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.14230880
2Nitrogen metabolism_Homo sapiens_hsa009103.36918880
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.19351663
4Oxidative phosphorylation_Homo sapiens_hsa001903.01125577
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99898073
6Arginine biosynthesis_Homo sapiens_hsa002202.82048418
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.71737942
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.70328260
9Tryptophan metabolism_Homo sapiens_hsa003802.69438786
10Fatty acid degradation_Homo sapiens_hsa000712.67269448
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65150939
12Complement and coagulation cascades_Homo sapiens_hsa046102.46827933
13Ribosome_Homo sapiens_hsa030102.46201867
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45807661
15Propanoate metabolism_Homo sapiens_hsa006402.34325910
16Parkinsons disease_Homo sapiens_hsa050122.32140137
17Butanoate metabolism_Homo sapiens_hsa006502.31716817
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21945565
19Peroxisome_Homo sapiens_hsa041462.18890076
20PPAR signaling pathway_Homo sapiens_hsa033202.09144227
21Fatty acid metabolism_Homo sapiens_hsa012122.06198571
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03246865
23RNA polymerase_Homo sapiens_hsa030201.86148498
24beta-Alanine metabolism_Homo sapiens_hsa004101.83479932
25Histidine metabolism_Homo sapiens_hsa003401.82880869
26Chemical carcinogenesis_Homo sapiens_hsa052041.79775444
27Homologous recombination_Homo sapiens_hsa034401.78661619
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78331354
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.76544094
30Huntingtons disease_Homo sapiens_hsa050161.73931929
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71570640
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.70065639
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69747141
34Proteasome_Homo sapiens_hsa030501.69609905
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.66542551
36Caffeine metabolism_Homo sapiens_hsa002321.66179435
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61901847
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61694440
39Phenylalanine metabolism_Homo sapiens_hsa003601.60579634
40Pyruvate metabolism_Homo sapiens_hsa006201.59344123
41Retinol metabolism_Homo sapiens_hsa008301.56444304
42Selenocompound metabolism_Homo sapiens_hsa004501.56231936
43Sulfur metabolism_Homo sapiens_hsa009201.55548074
44Staphylococcus aureus infection_Homo sapiens_hsa051501.53901752
45Alzheimers disease_Homo sapiens_hsa050101.53467829
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46738329
47Fatty acid elongation_Homo sapiens_hsa000621.45022651
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.40657507
49Bile secretion_Homo sapiens_hsa049761.38941750
50Starch and sucrose metabolism_Homo sapiens_hsa005001.30249532
51* Tyrosine metabolism_Homo sapiens_hsa003501.28713345
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28080282
53Carbon metabolism_Homo sapiens_hsa012001.26080761
54Folate biosynthesis_Homo sapiens_hsa007901.25652132
55Fat digestion and absorption_Homo sapiens_hsa049751.23670625
56Fanconi anemia pathway_Homo sapiens_hsa034601.22274012
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.21430202
58ABC transporters_Homo sapiens_hsa020101.17998778
59Biosynthesis of amino acids_Homo sapiens_hsa012301.15739528
60Cardiac muscle contraction_Homo sapiens_hsa042601.13291165
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07804992
62Pyrimidine metabolism_Homo sapiens_hsa002401.06419060
63Steroid biosynthesis_Homo sapiens_hsa001001.04956333
64Basal transcription factors_Homo sapiens_hsa030221.04040451
65Phototransduction_Homo sapiens_hsa047440.98469552
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98219931
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97914559
68Base excision repair_Homo sapiens_hsa034100.97492898
69Arginine and proline metabolism_Homo sapiens_hsa003300.96375662
70Mismatch repair_Homo sapiens_hsa034300.95903838
71Vitamin B6 metabolism_Homo sapiens_hsa007500.95173684
72DNA replication_Homo sapiens_hsa030300.94368538
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92549679
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92445532
75Glycerolipid metabolism_Homo sapiens_hsa005610.91151838
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.90002792
77Sulfur relay system_Homo sapiens_hsa041220.89126829
78Vitamin digestion and absorption_Homo sapiens_hsa049770.86871768
79Nucleotide excision repair_Homo sapiens_hsa034200.86555488
80Lysine degradation_Homo sapiens_hsa003100.83163331
81Fatty acid biosynthesis_Homo sapiens_hsa000610.82878922
82RNA degradation_Homo sapiens_hsa030180.80725726
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80718457
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76311652
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74789129
86Purine metabolism_Homo sapiens_hsa002300.73912035
87Glutathione metabolism_Homo sapiens_hsa004800.67134156
88Pentose phosphate pathway_Homo sapiens_hsa000300.62665421
89One carbon pool by folate_Homo sapiens_hsa006700.58780315
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56459653
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54369300
92Mineral absorption_Homo sapiens_hsa049780.51676429
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50750200
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50280533
95* Metabolic pathways_Homo sapiens_hsa011000.50279498
96RNA transport_Homo sapiens_hsa030130.45599540
97Ether lipid metabolism_Homo sapiens_hsa005650.44481412
98Collecting duct acid secretion_Homo sapiens_hsa049660.44339257
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42834098
100N-Glycan biosynthesis_Homo sapiens_hsa005100.41992689
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37576360
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.35691694
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35153246
104Insulin resistance_Homo sapiens_hsa049310.33915926
105Fructose and mannose metabolism_Homo sapiens_hsa000510.33566544
106Galactose metabolism_Homo sapiens_hsa000520.30919672
107Prion diseases_Homo sapiens_hsa050200.28069811
108Linoleic acid metabolism_Homo sapiens_hsa005910.27800881
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22942612
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.21337331
111Glucagon signaling pathway_Homo sapiens_hsa049220.20789459
112AMPK signaling pathway_Homo sapiens_hsa041520.18837279
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11521459
114Insulin signaling pathway_Homo sapiens_hsa049100.00653702
115Hepatitis C_Homo sapiens_hsa05160-0.1973105
116Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1913461
117Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1631151
118Protein digestion and absorption_Homo sapiens_hsa04974-0.1591367
119Lysosome_Homo sapiens_hsa04142-0.1549518
120Type II diabetes mellitus_Homo sapiens_hsa04930-0.1485864
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1453267
122Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1452503
123Renin-angiotensin system_Homo sapiens_hsa04614-0.1181133
124Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1106685
125Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1042665
126Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0728565
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0659657
128Protein export_Homo sapiens_hsa03060-0.0619124
129Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0594617
130Regulation of autophagy_Homo sapiens_hsa04140-0.0576078
131Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0405477
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0105665
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0095380

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