GSX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebral cortex neuron differentiation (GO:0021895)8.65873961
2forebrain neuron differentiation (GO:0021879)7.53462742
3lung secretory cell differentiation (GO:0061140)6.46297451
4base-excision repair, AP site formation (GO:0006285)6.32474961
5neuron cell-cell adhesion (GO:0007158)6.14328433
6dosage compensation (GO:0007549)5.67840835
7nonmotile primary cilium assembly (GO:0035058)5.58561860
8pyrimidine deoxyribonucleotide catabolic process (GO:0009223)5.48618718
9positive regulation of oligodendrocyte differentiation (GO:0048714)5.33641415
10neuronal stem cell maintenance (GO:0097150)5.27240206
11negative regulation of oligodendrocyte differentiation (GO:0048715)5.24481380
12endothelial tube morphogenesis (GO:0061154)5.07479305
13morphogenesis of an endothelium (GO:0003159)5.07479305
14locomotory exploration behavior (GO:0035641)4.98541095
15Notch signaling involved in heart development (GO:0061314)4.91000625
16regulation of oligodendrocyte differentiation (GO:0048713)4.81730818
17pyrimidine nucleotide catabolic process (GO:0006244)4.75956361
18* neuron fate commitment (GO:0048663)4.66674284
19respiratory tube development (GO:0030323)4.56737391
20ventricular trabecula myocardium morphogenesis (GO:0003222)4.53729763
21face development (GO:0060324)4.47449298
22metanephric nephron tubule development (GO:0072234)4.42802876
23metanephric tubule development (GO:0072170)4.42802876
24collecting duct development (GO:0072044)4.38963295
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.28283919
26appendage development (GO:0048736)4.23355801
27limb development (GO:0060173)4.23355801
28* spinal cord association neuron differentiation (GO:0021527)4.21189719
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.17456857
30DNA unwinding involved in DNA replication (GO:0006268)4.07142253
31positive regulation of Notch signaling pathway (GO:0045747)4.01970010
32nephron tubule development (GO:0072080)3.96657656
33postsynaptic membrane organization (GO:0001941)3.96079526
34ovulation cycle (GO:0042698)3.95040454
35pituitary gland development (GO:0021983)3.94667517
36metanephric nephron epithelium development (GO:0072243)3.93309089
37epithelial tube branching involved in lung morphogenesis (GO:0060441)3.92490852
38negative regulation of epithelial to mesenchymal transition (GO:0010719)3.91099608
39proximal/distal pattern formation (GO:0009954)3.90742102
40histone mRNA catabolic process (GO:0071044)3.89964719
41oligodendrocyte differentiation (GO:0048709)3.88720979
42heart trabecula morphogenesis (GO:0061384)3.85495016
43cardiac ventricle morphogenesis (GO:0003208)3.83788875
44RNA destabilization (GO:0050779)3.80921521
45G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.79488004
46positive regulation of circadian rhythm (GO:0042753)3.77849256
47negative regulation of glial cell differentiation (GO:0045686)3.74571809
48central nervous system projection neuron axonogenesis (GO:0021952)3.72237683
49segment specification (GO:0007379)3.71800532
50negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.70641647
51cell surface receptor signaling pathway involved in heart development (GO:0061311)3.69720992
52thalamus development (GO:0021794)3.66716341
53nucleobase catabolic process (GO:0046113)3.64066349
54alkaloid metabolic process (GO:0009820)3.63634642
55synapse assembly (GO:0007416)3.63287077
56renal tubule development (GO:0061326)3.62650076
57astrocyte differentiation (GO:0048708)3.60578411
58dermatan sulfate biosynthetic process (GO:0030208)3.60267278
59digestive tract morphogenesis (GO:0048546)3.56935091
60regulation of somitogenesis (GO:0014807)3.55901259
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.54602271
62embryonic cranial skeleton morphogenesis (GO:0048701)3.52589407
63developmental induction (GO:0031128)3.52247870
64negative regulation of thymocyte apoptotic process (GO:0070244)3.51459592
65L-serine transport (GO:0015825)3.48086057
66positive regulation of receptor biosynthetic process (GO:0010870)3.46651082
67mitotic G1 DNA damage checkpoint (GO:0031571)3.45116709
68pyrimidine nucleobase catabolic process (GO:0006208)3.43533674
69metanephric epithelium development (GO:0072207)3.43306887
70cell-cell signaling involved in cell fate commitment (GO:0045168)3.39972448
71spliceosomal complex assembly (GO:0000245)3.38880632
72carnitine metabolic process (GO:0009437)3.38360023
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.37921511
74Sertoli cell development (GO:0060009)3.35454900
75DNA replication-dependent nucleosome organization (GO:0034723)3.34874670
76DNA replication-dependent nucleosome assembly (GO:0006335)3.34874670
77cardiac chamber morphogenesis (GO:0003206)3.31363682
78cerebellar granule cell differentiation (GO:0021707)3.29968494
79dermatan sulfate metabolic process (GO:0030205)3.28061053
80negative regulation of interleukin-10 production (GO:0032693)3.27907023
81synaptic transmission, dopaminergic (GO:0001963)3.27174516
82Leydig cell differentiation (GO:0033327)3.26825197
83regulation of timing of cell differentiation (GO:0048505)3.26336329
84chondroitin sulfate catabolic process (GO:0030207)3.26203387
85neurotransmitter-gated ion channel clustering (GO:0072578)3.25253936
86regulation of gliogenesis (GO:0014013)3.24681678
87exploration behavior (GO:0035640)3.23382664
88calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.23113860
89response to folic acid (GO:0051593)3.23093113
90left/right axis specification (GO:0070986)3.22392470
91regulation of transcription involved in cell fate commitment (GO:0060850)3.22042442
92regulation of development, heterochronic (GO:0040034)3.21186331
93regulation of glutamate receptor signaling pathway (GO:1900449)3.19492830
94regulation of glial cell differentiation (GO:0045685)3.19462571
95regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14784375
96cellular response to fluid shear stress (GO:0071498)3.14640715
97vocalization behavior (GO:0071625)3.14284173
98nephron epithelium development (GO:0072009)3.13681702
99aggressive behavior (GO:0002118)3.13339190
100photoreceptor cell differentiation (GO:0046530)3.11918892
101eye photoreceptor cell differentiation (GO:0001754)3.11918892
102layer formation in cerebral cortex (GO:0021819)3.11093330
103chaperone mediated protein folding requiring cofactor (GO:0051085)3.10596308
104amino acid import (GO:0043090)3.10028671
105cellular response to nicotine (GO:0071316)3.09849379
106generation of neurons (GO:0048699)3.09146436
107ganglioside metabolic process (GO:0001573)3.08506524
108regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06726091
109DNA strand elongation involved in DNA replication (GO:0006271)3.06540417
110neuron recognition (GO:0008038)3.06401425
111establishment of nucleus localization (GO:0040023)3.03733608
112spinal cord motor neuron differentiation (GO:0021522)3.03551596
113negative regulation of gliogenesis (GO:0014014)3.02917593
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.02731740
115RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.02731740
116glial cell differentiation (GO:0010001)3.02728631
117cerebral cortex cell migration (GO:0021795)3.01174220
118negative regulation of astrocyte differentiation (GO:0048712)3.00350463
119DNA replication initiation (GO:0006270)2.97858615
120regulation of synapse structural plasticity (GO:0051823)2.96711941
121DNA damage response, detection of DNA damage (GO:0042769)2.96603236
122response to pheromone (GO:0019236)2.96431123
123negative regulation of epidermis development (GO:0045683)2.95365720
124peptidyl-arginine omega-N-methylation (GO:0035247)2.93338422
125thyroid gland development (GO:0030878)2.93282302
126left/right pattern formation (GO:0060972)2.91053833
127cerebral cortex radially oriented cell migration (GO:0021799)2.90093280
128G1 DNA damage checkpoint (GO:0044783)2.89350705
129positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.89238858
130behavioral response to nicotine (GO:0035095)2.89227812
131negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.88234554
132positive regulation of neural precursor cell proliferation (GO:2000179)2.88069952
133dendritic spine morphogenesis (GO:0060997)2.87894948
134dendrite morphogenesis (GO:0048813)2.87757880
135mitotic G1/S transition checkpoint (GO:0044819)2.86399054
136behavioral response to cocaine (GO:0048148)2.86063944
137presynaptic membrane organization (GO:0097090)2.85553376
138ganglion development (GO:0061548)2.84820989
139regulation of transcription from RNA polymerase I promoter (GO:0006356)2.83801826
140pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.83454871
141trabecula morphogenesis (GO:0061383)2.83123238
142cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.83038396
143serine transport (GO:0032329)2.82082346
144lung cell differentiation (GO:0060479)2.81932662
145peptidyl-lysine dimethylation (GO:0018027)2.81046537
146lateral sprouting from an epithelium (GO:0060601)2.80510079
147deoxyribonucleotide catabolic process (GO:0009264)2.78503897
148nephron tubule formation (GO:0072079)2.78338039
149olfactory bulb development (GO:0021772)2.78065306
150DNA strand elongation (GO:0022616)2.77587754
151positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.77478849
152lung epithelial cell differentiation (GO:0060487)2.77279508
153protein localization to synapse (GO:0035418)2.76979485
154regulation of respiratory system process (GO:0044065)2.76483752
155positive regulation of synapse assembly (GO:0051965)2.74984463
156cellular ketone body metabolic process (GO:0046950)2.74446431
157positive regulation of glial cell differentiation (GO:0045687)2.72258322
158hippocampus development (GO:0021766)2.71969692
159toxin metabolic process (GO:0009404)2.71528652
160synaptic vesicle exocytosis (GO:0016079)2.70709511
161ionotropic glutamate receptor signaling pathway (GO:0035235)2.70405126
162deoxyribonucleotide biosynthetic process (GO:0009263)2.69732530
163renal system development (GO:0072001)2.68887212
164substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.67196505
165substrate-independent telencephalic tangential migration (GO:0021826)2.67196505
166positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.66637480
167presynaptic membrane assembly (GO:0097105)2.66134287
168negative regulation of epidermal cell differentiation (GO:0045605)2.64335463
169regulation of glycogen (starch) synthase activity (GO:2000465)2.64327135
170positive regulation of dendritic spine morphogenesis (GO:0061003)2.63783723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.22016320
2E2F7_22180533_ChIP-Seq_HELA_Human5.90736003
3AR_21572438_ChIP-Seq_LNCaP_Human4.16558085
4EED_16625203_ChIP-ChIP_MESCs_Mouse3.14303702
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.08083204
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90795755
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.87137192
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79322879
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77358896
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.75158736
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.72799191
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67374666
13RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.63983869
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61690579
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61690579
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54934318
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51655100
18PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.42150030
19GBX2_23144817_ChIP-Seq_PC3_Human2.40180250
20* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38380935
21EZH2_22144423_ChIP-Seq_EOC_Human2.37712703
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28919638
23* CBX2_27304074_Chip-Seq_ESCs_Mouse2.28196975
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.22741187
25IGF1R_20145208_ChIP-Seq_DFB_Human2.15967590
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14086033
27EST1_17652178_ChIP-ChIP_JURKAT_Human2.09388138
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08620725
29ZNF274_21170338_ChIP-Seq_K562_Hela2.05468317
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05440965
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04572680
32* EZH2_27294783_Chip-Seq_ESCs_Mouse2.02828019
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.95928270
34* RNF2_27304074_Chip-Seq_ESCs_Mouse1.95228040
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93241799
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.90888584
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.87845859
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85908885
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85749574
40TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.84437836
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83788919
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.82201642
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79908584
44* RING1B_27294783_Chip-Seq_NPCs_Mouse1.78942524
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77089485
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75053798
47TP53_20018659_ChIP-ChIP_R1E_Mouse1.73331467
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72561291
49* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72540641
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72332083
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71976514
52SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.71566612
53* RING1B_27294783_Chip-Seq_ESCs_Mouse1.68889510
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.66634267
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.61605288
56DROSHA_22980978_ChIP-Seq_HELA_Human1.60357447
57* REST_21632747_ChIP-Seq_MESCs_Mouse1.55528201
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54071925
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53073736
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52758934
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52070074
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51471949
63GABP_19822575_ChIP-Seq_HepG2_Human1.49535044
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47479154
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46214521
66SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44570248
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43516907
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42276830
69KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41453176
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38691981
71ETS1_20019798_ChIP-Seq_JURKAT_Human1.37604849
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36329814
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34204557
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.33752823
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.30526863
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28957807
77MYC_18940864_ChIP-ChIP_HL60_Human1.26038455
78* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25994080
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25267785
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24238989
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24054466
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22177375
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21161246
84ELK1_19687146_ChIP-ChIP_HELA_Human1.20774092
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19671714
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.18334631
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.18143592
88TAF15_26573619_Chip-Seq_HEK293_Human1.15092185
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15032640
90E2F1_17053090_ChIP-ChIP_MCF-7_Human1.14346047
91ESR1_21235772_ChIP-Seq_MCF-7_Human1.13890084
92POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12818400
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12362995
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11221866
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10835330
96SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10310810
97POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08716363
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.08354900
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06665701
100FOXM1_23109430_ChIP-Seq_U2OS_Human1.06632977
101FUS_26573619_Chip-Seq_HEK293_Human1.05917338
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05635170
103YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05386881
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.03968584
105POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02961738
106EGR1_19032775_ChIP-ChIP_M12_Human1.02928408
107CDX2_20551321_ChIP-Seq_CACO-2_Human1.02635660
108* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01745367
109ER_23166858_ChIP-Seq_MCF-7_Human1.01100399
110E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00426002
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99190766
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98647670
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98152592
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98152592
115NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97325596
116PIAS1_25552417_ChIP-Seq_VCAP_Human0.96811986
117BCAT_22108803_ChIP-Seq_LS180_Human0.95804126
118YY1_21170310_ChIP-Seq_MESCs_Mouse0.95800015
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95633007
120SMAD3_21741376_ChIP-Seq_ESCs_Human0.94095130
121THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93653331
122GATA1_26923725_Chip-Seq_HPCs_Mouse0.92189623
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91984605
124TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91374158
125KDM2B_26808549_Chip-Seq_K562_Human0.91269636
126AR_21909140_ChIP-Seq_LNCAP_Human0.91207441
127KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91004777
128TBX3_20139965_ChIP-Seq_ESCs_Mouse0.90860365
129SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90423563
130TBX3_20139965_ChIP-Seq_MESCs_Mouse0.90346767
131SMAD4_21799915_ChIP-Seq_A2780_Human0.88426045
132RNF2_27304074_Chip-Seq_NSC_Mouse0.88359572
133LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88198911
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86400880
135KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86367657
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86367657
137IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86019332
138CBP_20019798_ChIP-Seq_JUKART_Human0.86019332
139REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85114948
140SOX3_22085726_ChIP-Seq_NPCs_Mouse0.84158116
141PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82921113
142PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80806040
143MYC_18555785_ChIP-Seq_MESCs_Mouse0.80380377
144MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80276196
145LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79699314
146RUNX2_22187159_ChIP-Seq_PCA_Human0.77148922
147CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.77028104
148* FOXP1_21924763_ChIP-Seq_HESCs_Human0.76159540
149CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75924732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence5.08304518
2MP0003880_abnormal_central_pattern4.07215136
3MP0008789_abnormal_olfactory_epithelium3.73653248
4MP0003122_maternal_imprinting3.46853476
5MP0009379_abnormal_foot_pigmentation3.45452847
6MP0003941_abnormal_skin_development3.42763128
7MP0001529_abnormal_vocalization3.25393377
8MP0005423_abnormal_somatic_nervous3.18969903
9MP0005499_abnormal_olfactory_system3.08458702
10MP0005394_taste/olfaction_phenotype3.08458702
11MP0004133_heterotaxia3.08237971
12MP0002102_abnormal_ear_morphology2.99889418
13MP0002822_catalepsy2.94570047
14MP0004859_abnormal_synaptic_plasticity2.80798695
15MP0000778_abnormal_nervous_system2.64262971
16MP0002736_abnormal_nociception_after2.61687337
17MP0002163_abnormal_gland_morphology2.43516889
18MP0004142_abnormal_muscle_tone2.42303859
19MP0002653_abnormal_ependyma_morphology2.38907792
20MP0003786_premature_aging2.26630201
21MP0002638_abnormal_pupillary_reflex2.19187194
22MP0001968_abnormal_touch/_nociception2.14148370
23MP0003646_muscle_fatigue2.12012145
24MP0004742_abnormal_vestibular_system2.11192565
25MP0003385_abnormal_body_wall2.08178786
26MP0003121_genomic_imprinting2.08042560
27MP0003635_abnormal_synaptic_transmissio2.06511698
28MP0003693_abnormal_embryo_hatching2.05980222
29MP0008877_abnormal_DNA_methylation1.99114251
30MP0009384_cardiac_valve_regurgitation1.93173007
31MP0005253_abnormal_eye_physiology1.93154422
32MP0009250_abnormal_appendicular_skeleto1.88461161
33MP0000049_abnormal_middle_ear1.85859554
34MP0000955_abnormal_spinal_cord1.85712599
35MP0002282_abnormal_trachea_morphology1.82057778
36MP0002184_abnormal_innervation1.81390776
37MP0000681_abnormal_thyroid_gland1.79462350
38MP0003136_yellow_coat_color1.77446178
39MP0008961_abnormal_basal_metabolism1.74651361
40* MP0000631_abnormal_neuroendocrine_gland1.74311318
41MP0002063_abnormal_learning/memory/cond1.72195690
42MP0003634_abnormal_glial_cell1.71993697
43MP0008007_abnormal_cellular_replicative1.70677849
44MP0003115_abnormal_respiratory_system1.69830686
45MP0000534_abnormal_ureter_morphology1.68508243
46MP0004885_abnormal_endolymph1.68125484
47MP0001486_abnormal_startle_reflex1.67436981
48MP0005257_abnormal_intraocular_pressure1.63749201
49MP0001905_abnormal_dopamine_level1.61873857
50MP0000467_abnormal_esophagus_morphology1.61563517
51MP0005379_endocrine/exocrine_gland_phen1.61451101
52MP0003861_abnormal_nervous_system1.60380406
53MP0001727_abnormal_embryo_implantation1.60370060
54MP0001984_abnormal_olfaction1.58329066
55MP0009745_abnormal_behavioral_response1.56715963
56MP0001270_distended_abdomen1.55332343
57MP0002009_preneoplasia1.48141916
58* MP0002067_abnormal_sensory_capabilities1.47700125
59MP0002064_seizures1.46171046
60* MP0002152_abnormal_brain_morphology1.45797872
61MP0004858_abnormal_nervous_system1.42783353
62MP0000733_abnormal_muscle_development1.42645481
63MP0002557_abnormal_social/conspecific_i1.42628161
64MP0002249_abnormal_larynx_morphology1.41471177
65MP0000579_abnormal_nail_morphology1.36157435
66MP0003787_abnormal_imprinting1.35328266
67MP0002751_abnormal_autonomic_nervous1.31628300
68MP0004811_abnormal_neuron_physiology1.31420278
69MP0002882_abnormal_neuron_morphology1.27756816
70MP0002572_abnormal_emotion/affect_behav1.27697570
71MP0008775_abnormal_heart_ventricle1.26605284
72MP0003959_abnormal_lean_body1.25660544
73MP0000428_abnormal_craniofacial_morphol1.25453674
74MP0002734_abnormal_mechanical_nocicepti1.25226169
75MP0003938_abnormal_ear_development1.24454382
76MP0005551_abnormal_eye_electrophysiolog1.24134154
77MP0000639_abnormal_adrenal_gland1.22180969
78MP0004270_analgesia1.21487773
79MP0004924_abnormal_behavior1.20737798
80MP0005386_behavior/neurological_phenoty1.20737798
81MP0000026_abnormal_inner_ear1.19527013
82MP0005248_abnormal_Harderian_gland1.18695814
83MP0006276_abnormal_autonomic_nervous1.18346642
84MP0000751_myopathy1.18171619
85MP0003755_abnormal_palate_morphology1.16711352
86MP0001188_hyperpigmentation1.14386694
87MP0005391_vision/eye_phenotype1.14002270
88MP0001502_abnormal_circadian_rhythm1.13838510
89MP0000920_abnormal_myelination1.13692922
90MP0002066_abnormal_motor_capabilities/c1.13032079
91MP0003091_abnormal_cell_migration1.12229020
92MP0002116_abnormal_craniofacial_bone1.12194841
93MP0006138_congestive_heart_failure1.12113522
94MP0004883_abnormal_blood_vessel1.10548906
95MP0004215_abnormal_myocardial_fiber1.10223058
96MP0002697_abnormal_eye_size1.09274433
97MP0001943_abnormal_respiration1.09119538
98MP0002733_abnormal_thermal_nociception1.07197000
99MP0004134_abnormal_chest_morphology1.06474419
100MP0008875_abnormal_xenobiotic_pharmacok1.05442764
101MP0003935_abnormal_craniofacial_develop1.03495404
102MP0005171_absent_coat_pigmentation1.02169874
103MP0002233_abnormal_nose_morphology1.01763637
104* MP0005647_abnormal_sex_gland1.00921218
105MP0005195_abnormal_posterior_eye0.99845493
106MP0002272_abnormal_nervous_system0.99841176
107MP0003183_abnormal_peptide_metabolism0.97970628
108MP0001915_intracranial_hemorrhage0.97651358
109MP0001963_abnormal_hearing_physiology0.95161084
110MP0002735_abnormal_chemical_nociception0.94334876
111MP0001958_emphysema0.93618508
112MP0003942_abnormal_urinary_system0.93305889
113MP0002752_abnormal_somatic_nervous0.92173513
114MP0002084_abnormal_developmental_patter0.92006205
115MP0003221_abnormal_cardiomyocyte_apopto0.90828563
116MP0002254_reproductive_system_inflammat0.89876633
117MP0008569_lethality_at_weaning0.89401922
118MP0003690_abnormal_glial_cell0.88888386
119MP0004272_abnormal_basement_membrane0.86803591
120MP0004197_abnormal_fetal_growth/weight/0.86535904
121MP0010368_abnormal_lymphatic_system0.86420383
122* MP0000432_abnormal_head_morphology0.86132917
123MP0001324_abnormal_eye_pigmentation0.84571010
124MP0000767_abnormal_smooth_muscle0.84511498
125MP0000647_abnormal_sebaceous_gland0.84017850
126* MP0000163_abnormal_cartilage_morphology0.83448216
127MP0002090_abnormal_vision0.83369742
128MP0002081_perinatal_lethality0.81459554
129MP0003119_abnormal_digestive_system0.81379594
130MP0006072_abnormal_retinal_apoptosis0.81343687
131MP0010678_abnormal_skin_adnexa0.80573327
132MP0001177_atelectasis0.80503028
133MP0002332_abnormal_exercise_endurance0.80205090
134* MP0005645_abnormal_hypothalamus_physiol0.80196742
135MP0001664_abnormal_digestion0.79658257
136MP0005076_abnormal_cell_differentiation0.79001498
137* MP0010770_preweaning_lethality0.78768904
138* MP0002082_postnatal_lethality0.78768904
139MP0003937_abnormal_limbs/digits/tail_de0.78567587
140MP0002139_abnormal_hepatobiliary_system0.78401047
141MP0002085_abnormal_embryonic_tissue0.77438917
142MP0005167_abnormal_blood-brain_barrier0.76121044
143MP0001970_abnormal_pain_threshold0.76106337
144MP0003137_abnormal_impulse_conducting0.75795929
145MP0003567_abnormal_fetal_cardiomyocyte0.75124099
146* MP0010769_abnormal_survival0.74310771
147MP0002069_abnormal_eating/drinking_beha0.74156166
148MP0001485_abnormal_pinna_reflex0.72997621
149MP0009046_muscle_twitch0.69864803
150MP0001286_abnormal_eye_development0.69421653
151MP0003283_abnormal_digestive_organ0.67222065

Predicted human phenotypes

RankGene SetZ-score
1Neonatal respiratory distress (HP:0002643)8.29966723
2Thyroid-stimulating hormone excess (HP:0002925)8.11783683
3Tubulointerstitial nephritis (HP:0001970)6.70886524
4Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.56966340
5Abnormality of the labia minora (HP:0012880)4.26232506
6Oligodactyly (hands) (HP:0001180)4.19324497
7Decreased lacrimation (HP:0000633)3.68274063
8Esophageal atresia (HP:0002032)3.67807133
9Facial hemangioma (HP:0000329)3.57915705
10Anophthalmia (HP:0000528)3.38941852
11Hepatoblastoma (HP:0002884)3.37785248
12Alacrima (HP:0000522)3.28562713
13Aplasia/Hypoplasia of the sternum (HP:0006714)3.21770303
14Peripheral hypomyelination (HP:0007182)3.18682841
15Retinal dysplasia (HP:0007973)3.17291294
16Hypoplastic pelvis (HP:0008839)3.14143828
17Tubulointerstitial abnormality (HP:0001969)3.13773746
18Atrophy/Degeneration involving motor neurons (HP:0007373)3.11970828
19Neoplasm of the peripheral nervous system (HP:0100007)3.08892658
20Fibular hypoplasia (HP:0003038)3.08455065
21Bronchomalacia (HP:0002780)3.03400386
22Septo-optic dysplasia (HP:0100842)3.03172599
23Oligodactyly (HP:0012165)3.02894233
24Partial agenesis of the corpus callosum (HP:0001338)2.98389612
25Microglossia (HP:0000171)2.98355968
26Intestinal atresia (HP:0011100)2.94559532
27Cerebral hypomyelination (HP:0006808)2.86718102
28Broad distal phalanx of finger (HP:0009836)2.85949049
29Adactyly (HP:0009776)2.85814089
30Menstrual irregularities (HP:0000858)2.82147586
31Split foot (HP:0001839)2.82105455
32Hyperpituitarism (HP:0010514)2.77265544
33Hypokinesia (HP:0002375)2.77104870
34Annular pancreas (HP:0001734)2.76240792
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.74676137
36Abnormality of alanine metabolism (HP:0010916)2.74676137
37Hyperalaninemia (HP:0003348)2.74676137
38Aplasia/Hypoplasia of the nipples (HP:0006709)2.72038637
39Type II lissencephaly (HP:0007260)2.69093662
40Death in childhood (HP:0003819)2.66892146
41Abnormality of secondary sexual hair (HP:0009888)2.65980636
42Abnormality of the axillary hair (HP:0100134)2.65980636
43Esophageal neoplasm (HP:0100751)2.64958465
44Neoplasm of head and neck (HP:0012288)2.64958465
45Synostosis involving the elbow (HP:0003938)2.63370022
46Humeroradial synostosis (HP:0003041)2.63370022
47Pendular nystagmus (HP:0012043)2.63350541
48Cerebral palsy (HP:0100021)2.60766979
49Broad ribs (HP:0000885)2.57663370
50Optic nerve hypoplasia (HP:0000609)2.56041124
51Spastic diplegia (HP:0001264)2.55982688
52Abnormality of the pubic bones (HP:0003172)2.55114116
53Complete atrioventricular canal defect (HP:0001674)2.49236285
54Axonal loss (HP:0003447)2.48942555
55Megalencephaly (HP:0001355)2.48370290
56Keratoconus (HP:0000563)2.47777933
57Increased corneal curvature (HP:0100692)2.47777933
58Birth length less than 3rd percentile (HP:0003561)2.47672419
59Failure to thrive in infancy (HP:0001531)2.46293968
60Shallow orbits (HP:0000586)2.45675965
61Hyperglycinemia (HP:0002154)2.44474969
62Cortical dysplasia (HP:0002539)2.39071878
63Abnormality of the 4th metacarpal (HP:0010012)2.38937614
64Maternal diabetes (HP:0009800)2.38531797
65Delayed CNS myelination (HP:0002188)2.36672051
66Slow-growing hair (HP:0002217)2.32868622
67Abnormality of hair growth rate (HP:0011363)2.32868622
68Hepatocellular necrosis (HP:0001404)2.31544349
69Fibrous tissue neoplasm (HP:0012316)2.30752701
70Urethral obstruction (HP:0000796)2.29993547
71Aplasia/Hypoplasia of the fibula (HP:0006492)2.28440225
72Hemivertebrae (HP:0002937)2.28159257
73Choanal stenosis (HP:0000452)2.27537656
74Abnormality of the intervertebral disk (HP:0005108)2.27196991
75Obsessive-compulsive behavior (HP:0000722)2.26928686
76High pitched voice (HP:0001620)2.26553005
77Chronic hepatic failure (HP:0100626)2.26346580
78Obstructive sleep apnea (HP:0002870)2.23396796
79Goiter (HP:0000853)2.23136671
80Renal cortical cysts (HP:0000803)2.23006147
81Diminished movement (HP:0002374)2.21921538
82Myokymia (HP:0002411)2.21723088
83Limb dystonia (HP:0002451)2.20409571
84Glossoptosis (HP:0000162)2.20183830
85Degeneration of the lateral corticospinal tracts (HP:0002314)2.16671150
86Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16671150
87Polyphagia (HP:0002591)2.16282371
88Colon cancer (HP:0003003)2.15595695
89Anxiety (HP:0000739)2.13899915
90Fibroma (HP:0010614)2.12749220
91Choreoathetosis (HP:0001266)2.10969917
92Broad alveolar ridges (HP:0000187)2.09187506
93Lissencephaly (HP:0001339)2.08490431
94Concave nail (HP:0001598)2.07028997
95Acute necrotizing encephalopathy (HP:0006965)2.06622771
96Respiratory distress (HP:0002098)2.03595519
97Scrotal hypoplasia (HP:0000046)2.03202401
98Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.02386441
99Pachygyria (HP:0001302)2.02332184
100Gastrointestinal atresia (HP:0002589)2.00824801
101Abnormality of the metopic suture (HP:0005556)1.99481148
102Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99037513
103Short 4th metacarpal (HP:0010044)1.99037513
104Progressive microcephaly (HP:0000253)1.98649982
105Abnormal neuron morphology (HP:0012757)1.97988917
106Abnormality of the motor neurons (HP:0002450)1.97988917
107Split hand (HP:0001171)1.96915911
108Vitreoretinal degeneration (HP:0000655)1.96559423
109Increased serum pyruvate (HP:0003542)1.95536095
110Agitation (HP:0000713)1.95158835
111Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95120023
112Supernumerary spleens (HP:0009799)1.94553473
113Abnormality of midbrain morphology (HP:0002418)1.94224022
114Molar tooth sign on MRI (HP:0002419)1.94224022
115Sex reversal (HP:0012245)1.93506964
116Abnormal sex determination (HP:0012244)1.93506964
117Progressive macrocephaly (HP:0004481)1.93364190
118Apathy (HP:0000741)1.93040380
119Germ cell neoplasia (HP:0100728)1.92909714
120Bicornuate uterus (HP:0000813)1.92626195
121Amyotrophic lateral sclerosis (HP:0007354)1.91784988
122Poor suck (HP:0002033)1.91167286
123Labial hypoplasia (HP:0000066)1.90705762
124Abnormality of glycolysis (HP:0004366)1.88667433
125Renovascular hypertension (HP:0100817)1.88580221
126CNS demyelination (HP:0007305)1.88498400
127Excessive salivation (HP:0003781)1.88185134
128Drooling (HP:0002307)1.88185134
129Abnormality of the diencephalon (HP:0010662)1.87256072
130Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.86585266
131Nephronophthisis (HP:0000090)1.86473900
132Heterotopia (HP:0002282)1.86377451
133Conjugated hyperbilirubinemia (HP:0002908)1.85746809
134Wide cranial sutures (HP:0010537)1.85610244
135Cerebellar dysplasia (HP:0007033)1.85597371
136Conjunctival telangiectasia (HP:0000524)1.85022277
137Esotropia (HP:0000565)1.84441743
138Breast aplasia (HP:0100783)1.83580034
139Renal hypoplasia (HP:0000089)1.83308147
140Abnormality of the renal medulla (HP:0100957)1.82992010
141Shoulder girdle muscle weakness (HP:0003547)1.82556776
142Abnormality of placental membranes (HP:0011409)1.81414608
143Amniotic constriction ring (HP:0009775)1.81414608
144Atrioventricular canal defect (HP:0006695)1.80631213
145Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80583344
146Hypoplasia of the brainstem (HP:0002365)1.80583344
147Hypsarrhythmia (HP:0002521)1.80417463
148Poor head control (HP:0002421)1.79760019
149Hypoplastic nipples (HP:0002557)1.79516940
150True hermaphroditism (HP:0010459)1.77724981
151Anterior segment dysgenesis (HP:0007700)1.76677051
152Visual hallucinations (HP:0002367)1.76387131
153Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.75746236
154Intention tremor (HP:0002080)1.75449136
155Fibular aplasia (HP:0002990)1.75391239
156Increased nuchal translucency (HP:0010880)1.75170763
157Opisthotonus (HP:0002179)1.74675023
158Palpebral edema (HP:0100540)1.74569459
159Spina bifida occulta (HP:0003298)1.74434896
160Proximal placement of thumb (HP:0009623)1.74218728
161Abnormality of the lower motor neuron (HP:0002366)1.74210934
162Sporadic (HP:0003745)1.73827563
163Specific learning disability (HP:0001328)1.72648284
164Absent septum pellucidum (HP:0001331)1.72487165
165Pancreatic fibrosis (HP:0100732)1.72290277
166Bundle branch block (HP:0011710)1.71786945
167Neoplasm of the oral cavity (HP:0100649)1.71535717
168EEG with generalized epileptiform discharges (HP:0011198)1.71437689
169Cerebellar hypoplasia (HP:0001321)1.70586031
170Short philtrum (HP:0000322)1.69968515
171Genetic anticipation (HP:0003743)1.69918128
172Absent speech (HP:0001344)1.69713508
173Rimmed vacuoles (HP:0003805)1.69202808
174Dyskinesia (HP:0100660)1.68769527
175CNS hypomyelination (HP:0003429)1.68374489
176Abnormal eating behavior (HP:0100738)1.67233632
177Hypoplasia of the corpus callosum (HP:0002079)1.65187968
178Fetal akinesia sequence (HP:0001989)1.65066179

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.09560822
2PDGFRA3.42729006
3BCR3.21739465
4MARK13.17806044
5MAP4K23.15878896
6ERBB43.05803597
7CSNK1G32.90900071
8CSNK1A1L2.65027878
9MAP2K72.63913686
10CSNK1G22.61728096
11BUB12.45943524
12CSNK1G12.42865001
13PLK42.25474280
14NTRK32.21568445
15PHKG12.18823007
16PHKG22.18823007
17PRPF4B2.18044768
18SCYL22.18001936
19YES12.10635838
20TRIM282.04254220
21PRKD32.04041123
22GRK71.96919320
23WNK31.91662640
24TYRO31.91081696
25AKT31.89199070
26MAP3K121.81292949
27MAPK131.71892277
28BMPR1B1.71135850
29VRK11.71106910
30TAOK21.70878091
31PAK61.67040940
32UHMK11.55267477
33MKNK21.54561773
34PLK21.53827249
35MAP3K41.53616271
36PDGFRB1.52053973
37PAK31.50203647
38CDK71.47883770
39CDC71.47338324
40NTRK21.43654690
41CDK191.42105132
42KSR11.41466879
43FES1.41443917
44CDK81.37091863
45KSR21.34090754
46MKNK11.32739428
47CAMK1D1.28789337
48BRAF1.27020826
49PKN11.26758624
50DYRK21.26566116
51PNCK1.25796488
52TNIK1.24417224
53PLK31.21839850
54TGFBR11.19557354
55MAPK151.19506533
56MAPK111.17420231
57ERBB21.15212237
58ARAF1.14624028
59PBK1.08882489
60TSSK61.04249974
61BMX1.02857416
62DDR21.01158664
63DYRK30.97114017
64KIT0.95294262
65RPS6KA50.92217601
66CHEK20.92064398
67EEF2K0.91807390
68CAMK2D0.91245904
69PASK0.90364539
70LIMK10.89073914
71WNK10.87500290
72FER0.87421604
73SIK20.87383151
74DAPK10.84418932
75ROCK20.83372500
76CSNK1D0.82803345
77NEK10.82797154
78PIM20.80694158
79WNK40.78332220
80PRKAA20.77524725
81MINK10.73406792
82CAMK1G0.71724416
83FLT30.71162471
84EPHA40.70846718
85FGR0.70474136
86WEE10.70276072
87TESK20.70170887
88CDC42BPA0.69652453
89SRPK10.69164951
90NEK60.68463689
91CDK50.68199371
92MAP3K110.66258812
93MAPK70.66174809
94LMTK20.62157124
95NEK20.61722361
96ADRBK20.60904566
97ZAK0.60298702
98CDK11A0.59232971
99STK38L0.56395648
100SIK30.56155986
101TESK10.55475525
102ADRBK10.54506950
103MATK0.54354736
104CAMK2B0.53987983
105LRRK20.53850994
106PRKCZ0.53642186
107RAF10.53541908
108MAPKAPK50.53255570
109CDK140.51211617
110EPHB10.50922690
111CDK30.50790900
112NTRK10.50296678
113CSNK1A10.49096220
114CAMK2A0.48818666
115PRKCH0.48802101
116CAMK2G0.48631825
117CDK150.46524815
118RPS6KB10.46025122
119DMPK0.44524118
120ERBB30.44128212
121CDK180.43828630
122CDK10.43308999
123NME10.43229539
124PRKCG0.41870380
125PRKACB0.41504501
126SRC0.41391453
127GSK3A0.41313355
128KDR0.39993369
129INSRR0.39876878
130ICK0.39711001
131DYRK1A0.39242380
132DYRK1B0.38913699
133MAP2K40.38475422
134SGK2230.37285143
135SGK4940.37285143
136RPS6KA30.37180920
137DAPK20.37088701
138CCNB10.36004086
139MAPK100.35896786
140CDK20.35762003
141HIPK20.35731400
142GRK10.35037015
143FGFR20.34823898
144CHEK10.34448985
145PRKDC0.34239098
146RET0.33670214
147ATR0.32735737
148PLK10.32578514

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.93282715
2Sulfur relay system_Homo sapiens_hsa041223.24373196
3Mismatch repair_Homo sapiens_hsa034303.20332631
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.88395575
5Notch signaling pathway_Homo sapiens_hsa043302.80963842
6Glioma_Homo sapiens_hsa052142.36602311
7Protein export_Homo sapiens_hsa030602.33509363
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24066877
9Axon guidance_Homo sapiens_hsa043602.08245431
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02102876
11Lysine degradation_Homo sapiens_hsa003102.00878010
12Nicotine addiction_Homo sapiens_hsa050331.99077339
13RNA polymerase_Homo sapiens_hsa030201.98732302
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.95139106
15Gap junction_Homo sapiens_hsa045401.81121706
16Bladder cancer_Homo sapiens_hsa052191.75666895
17Cocaine addiction_Homo sapiens_hsa050301.72456311
18Cell cycle_Homo sapiens_hsa041101.70692097
19Parkinsons disease_Homo sapiens_hsa050121.70172715
20Glutamatergic synapse_Homo sapiens_hsa047241.66733736
21Proteasome_Homo sapiens_hsa030501.60807264
22MicroRNAs in cancer_Homo sapiens_hsa052061.58199176
23Fanconi anemia pathway_Homo sapiens_hsa034601.55794741
24Oxidative phosphorylation_Homo sapiens_hsa001901.48424470
25Nitrogen metabolism_Homo sapiens_hsa009101.42027156
26Hedgehog signaling pathway_Homo sapiens_hsa043401.40261246
27Prion diseases_Homo sapiens_hsa050201.38676492
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.38206241
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35202848
30GABAergic synapse_Homo sapiens_hsa047271.32473177
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30583350
32Circadian entrainment_Homo sapiens_hsa047131.30530364
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30272179
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27417290
35Basal cell carcinoma_Homo sapiens_hsa052171.26301403
36Nucleotide excision repair_Homo sapiens_hsa034201.22036856
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21447913
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19927309
39Butanoate metabolism_Homo sapiens_hsa006501.18713527
40Estrogen signaling pathway_Homo sapiens_hsa049151.17772124
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15185615
42Spliceosome_Homo sapiens_hsa030401.14601203
43Glycerolipid metabolism_Homo sapiens_hsa005611.13774913
44Non-homologous end-joining_Homo sapiens_hsa034501.12287534
45Folate biosynthesis_Homo sapiens_hsa007901.12244668
46Homologous recombination_Homo sapiens_hsa034401.11355626
47ErbB signaling pathway_Homo sapiens_hsa040121.10256830
48Long-term depression_Homo sapiens_hsa047301.08447611
49Amphetamine addiction_Homo sapiens_hsa050311.07375488
50Melanoma_Homo sapiens_hsa052181.05864859
51Non-small cell lung cancer_Homo sapiens_hsa052231.05565650
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03191401
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03001098
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02788371
55Morphine addiction_Homo sapiens_hsa050321.02549005
56Renal cell carcinoma_Homo sapiens_hsa052111.01387641
57Propanoate metabolism_Homo sapiens_hsa006401.01290079
58Dopaminergic synapse_Homo sapiens_hsa047280.99366096
59Melanogenesis_Homo sapiens_hsa049160.99129313
60RNA transport_Homo sapiens_hsa030130.97080671
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.95574074
62Insulin secretion_Homo sapiens_hsa049110.94858475
63Long-term potentiation_Homo sapiens_hsa047200.93051844
64beta-Alanine metabolism_Homo sapiens_hsa004100.92690222
65Fatty acid metabolism_Homo sapiens_hsa012120.92318935
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91321845
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89562551
68Alzheimers disease_Homo sapiens_hsa050100.89474479
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89219547
70RNA degradation_Homo sapiens_hsa030180.89126016
71Renin secretion_Homo sapiens_hsa049240.88844788
72Fat digestion and absorption_Homo sapiens_hsa049750.88328957
73Cholinergic synapse_Homo sapiens_hsa047250.87862276
74Ribosome_Homo sapiens_hsa030100.87818767
75GnRH signaling pathway_Homo sapiens_hsa049120.85844509
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84254897
77Wnt signaling pathway_Homo sapiens_hsa043100.82114968
78Oxytocin signaling pathway_Homo sapiens_hsa049210.81571463
79Hippo signaling pathway_Homo sapiens_hsa043900.80988140
80Taste transduction_Homo sapiens_hsa047420.79357948
81Vitamin B6 metabolism_Homo sapiens_hsa007500.78464593
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77313867
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76508320
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74433764
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.74051472
86Serotonergic synapse_Homo sapiens_hsa047260.73473777
87Alcoholism_Homo sapiens_hsa050340.73284110
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72773392
89Prostate cancer_Homo sapiens_hsa052150.72483364
90Cardiac muscle contraction_Homo sapiens_hsa042600.71741012
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71332222
92Huntingtons disease_Homo sapiens_hsa050160.71326402
93Base excision repair_Homo sapiens_hsa034100.70928934
94Basal transcription factors_Homo sapiens_hsa030220.70621151
95Caffeine metabolism_Homo sapiens_hsa002320.70087996
96Ether lipid metabolism_Homo sapiens_hsa005650.65617565
97Steroid biosynthesis_Homo sapiens_hsa001000.65613291
98Oocyte meiosis_Homo sapiens_hsa041140.64026416
99Sphingolipid metabolism_Homo sapiens_hsa006000.63541158
100HTLV-I infection_Homo sapiens_hsa051660.63178998
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63004677
102Chronic myeloid leukemia_Homo sapiens_hsa052200.60675593
103Calcium signaling pathway_Homo sapiens_hsa040200.60608788
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58864006
105Gastric acid secretion_Homo sapiens_hsa049710.57465875
106Dilated cardiomyopathy_Homo sapiens_hsa054140.57124736
107Peroxisome_Homo sapiens_hsa041460.54445285
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54404097
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54126015
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53955516
111Phototransduction_Homo sapiens_hsa047440.53936864
112Synaptic vesicle cycle_Homo sapiens_hsa047210.53921016
113Fatty acid elongation_Homo sapiens_hsa000620.53913552
114Pyrimidine metabolism_Homo sapiens_hsa002400.52734661
115Choline metabolism in cancer_Homo sapiens_hsa052310.52516360
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52203648
117Tight junction_Homo sapiens_hsa045300.51823624
118mRNA surveillance pathway_Homo sapiens_hsa030150.50353522
119Fatty acid biosynthesis_Homo sapiens_hsa000610.49578388
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49555561
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49145865
122Bile secretion_Homo sapiens_hsa049760.48523454
123Endometrial cancer_Homo sapiens_hsa052130.46807010
124TGF-beta signaling pathway_Homo sapiens_hsa043500.46755666
125Primary bile acid biosynthesis_Homo sapiens_hsa001200.46552105
126Dorso-ventral axis formation_Homo sapiens_hsa043200.45864775
127Olfactory transduction_Homo sapiens_hsa047400.45084400
128Pancreatic cancer_Homo sapiens_hsa052120.44134743
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44039000
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43806183
131Tyrosine metabolism_Homo sapiens_hsa003500.43515390
132Arginine and proline metabolism_Homo sapiens_hsa003300.42512690
133MAPK signaling pathway_Homo sapiens_hsa040100.41887982
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41524578
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41301746
136Purine metabolism_Homo sapiens_hsa002300.40710610
137Rap1 signaling pathway_Homo sapiens_hsa040150.40392950
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39801656
139Fatty acid degradation_Homo sapiens_hsa000710.39396419
140Pyruvate metabolism_Homo sapiens_hsa006200.38502230
141Histidine metabolism_Homo sapiens_hsa003400.34000559
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33114360
143Metabolic pathways_Homo sapiens_hsa011000.32366308

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