GSX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bone trabecula formation (GO:0060346)8.75528357
2atrial cardiac muscle cell action potential (GO:0086014)8.41111461
3membrane repolarization during cardiac muscle cell action potential (GO:0086013)7.67947326
4cellular response to nitric oxide (GO:0071732)6.97662599
5membrane repolarization during action potential (GO:0086011)6.79817736
6negative regulation of potassium ion transmembrane transport (GO:1901380)6.68901095
7potassium ion export (GO:0071435)6.60080627
8vitamin A metabolic process (GO:0006776)6.55199760
9regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)6.32371445
10pinocytosis (GO:0006907)6.23889199
113-UTR-mediated mRNA stabilization (GO:0070935)5.97809074
12L-serine metabolic process (GO:0006563)5.94067227
13positive regulation of growth hormone secretion (GO:0060124)5.69938571
14growth hormone secretion (GO:0030252)5.64656023
15isoprenoid biosynthetic process (GO:0008299)5.55726405
16cell morphogenesis involved in neuron differentiation (GO:0048667)5.50277656
17positive regulation of potassium ion transmembrane transport (GO:1901381)5.41265924
18regulation of growth hormone secretion (GO:0060123)5.33149620
19membrane repolarization (GO:0086009)5.23629341
20regulation of autophagic vacuole assembly (GO:2000785)5.23536296
21negative regulation of oligodendrocyte differentiation (GO:0048715)4.97699727
22sequestering of actin monomers (GO:0042989)4.95393339
23cholesterol biosynthetic process (GO:0006695)4.94713081
24negative regulation of astrocyte differentiation (GO:0048712)4.91473457
25cerebral cortex neuron differentiation (GO:0021895)4.77187272
26regulation of timing of cell differentiation (GO:0048505)4.69090551
27DNA strand elongation involved in DNA replication (GO:0006271)4.62309750
28pyrimidine nucleobase catabolic process (GO:0006208)4.60697291
29response to nitric oxide (GO:0071731)4.60399117
30cellular response to reactive nitrogen species (GO:1902170)4.49207870
31regulation of vacuole organization (GO:0044088)4.48587923
32biotin metabolic process (GO:0006768)4.45626718
33cellular response to cholesterol (GO:0071397)4.41157694
34regulation of development, heterochronic (GO:0040034)4.39413333
35DNA strand elongation (GO:0022616)4.35759504
36neuronal stem cell maintenance (GO:0097150)4.28952532
37nonmotile primary cilium assembly (GO:0035058)4.27548445
38layer formation in cerebral cortex (GO:0021819)4.23750966
39sterol biosynthetic process (GO:0016126)4.21350865
40cardiac left ventricle morphogenesis (GO:0003214)4.16913457
41regulation of sister chromatid cohesion (GO:0007063)4.10432521
42G2 DNA damage checkpoint (GO:0031572)4.01023722
43negative regulation of glial cell differentiation (GO:0045686)4.00559833
44aggressive behavior (GO:0002118)4.00547038
45DNA double-strand break processing (GO:0000729)4.00092339
46regulation of membrane repolarization (GO:0060306)3.95870246
47ubiquinone metabolic process (GO:0006743)3.94505792
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.90799294
49postsynaptic membrane organization (GO:0001941)3.90476880
50paraxial mesoderm development (GO:0048339)3.90250906
51intraciliary transport (GO:0042073)3.90158467
52neuron fate determination (GO:0048664)3.90135186
53* regulation of oligodendrocyte differentiation (GO:0048713)3.85104611
54olfactory bulb development (GO:0021772)3.83175519
55positive regulation of neural precursor cell proliferation (GO:2000179)3.82085346
56serine family amino acid biosynthetic process (GO:0009070)3.80755330
57mitotic sister chromatid cohesion (GO:0007064)3.72989597
58ventricular cardiac muscle cell action potential (GO:0086005)3.72006760
59cellular response to sterol (GO:0036315)3.68599301
60dentate gyrus development (GO:0021542)3.67677932
61positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.64987618
62response to lipoprotein particle (GO:0055094)3.64868698
63serine family amino acid catabolic process (GO:0009071)3.63818731
64auditory receptor cell differentiation (GO:0042491)3.63084785
65hepatocyte apoptotic process (GO:0097284)3.59747090
66central nervous system myelination (GO:0022010)3.56121326
67axon ensheathment in central nervous system (GO:0032291)3.56121326
68synaptic vesicle maturation (GO:0016188)3.51964558
69response to auditory stimulus (GO:0010996)3.50573210
70retinal rod cell development (GO:0046548)3.50430231
71nucleobase catabolic process (GO:0046113)3.49751187
72telomere maintenance via semi-conservative replication (GO:0032201)3.48687428
73mitotic G2 DNA damage checkpoint (GO:0007095)3.46664669
74DNA topological change (GO:0006265)3.44435856
75presynaptic membrane assembly (GO:0097105)3.44379645
76cilium morphogenesis (GO:0060271)3.43629449
77central nervous system projection neuron axonogenesis (GO:0021952)3.39690507
78negative regulation of gliogenesis (GO:0014014)3.39556482
79protein K11-linked ubiquitination (GO:0070979)3.32828367
80epithelial cilium movement (GO:0003351)3.31184363
81* forebrain neuron differentiation (GO:0021879)3.29914142
82ganglion development (GO:0061548)3.25817602
83* neuron fate commitment (GO:0048663)3.24689229
84regulation of response to osmotic stress (GO:0047484)3.24172630
85attachment of spindle microtubules to kinetochore (GO:0008608)3.22969897
86C-terminal protein lipidation (GO:0006501)3.22570567
87negative regulation of smoothened signaling pathway (GO:0045879)3.21006889
88cell proliferation in forebrain (GO:0021846)3.20885167
89regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.20094078
90DNA damage response, detection of DNA damage (GO:0042769)3.18281836
91regulation of DNA damage checkpoint (GO:2000001)3.17962602
92ubiquinone biosynthetic process (GO:0006744)3.17376744
93positive regulation of neuroblast proliferation (GO:0002052)3.16999517
94telomere maintenance via telomere lengthening (GO:0010833)3.16937022
95negative regulation of telomerase activity (GO:0051974)3.16901246
96proline metabolic process (GO:0006560)3.15960537
97negative regulation of potassium ion transport (GO:0043267)3.14362304
98oligodendrocyte differentiation (GO:0048709)3.14351438
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13855873
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13855873
101amino acid salvage (GO:0043102)3.12603383
102L-methionine salvage (GO:0071267)3.12603383
103L-methionine biosynthetic process (GO:0071265)3.12603383
104hair cell differentiation (GO:0035315)3.10377810
105negative regulation of hormone biosynthetic process (GO:0032353)3.07730305
106negative regulation of hormone metabolic process (GO:0032351)3.07730305
107cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.06678166
108substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.05407326
109substrate-independent telencephalic tangential migration (GO:0021826)3.05407326
110chaperone-mediated protein transport (GO:0072321)3.04809490
111nucleotide-excision repair, DNA gap filling (GO:0006297)3.04615365
112regulation of DNA endoreduplication (GO:0032875)3.04285923
113cerebral cortex radially oriented cell migration (GO:0021799)3.02704988
114glial cell proliferation (GO:0014009)3.02086045
115RNA stabilization (GO:0043489)3.01282812
116mRNA stabilization (GO:0048255)3.01282812
117regulation of heart rate by cardiac conduction (GO:0086091)3.00789715
118vitamin catabolic process (GO:0009111)2.99563766
119fat-soluble vitamin catabolic process (GO:0042363)2.99563766
120generation of neurons (GO:0048699)2.98578581
121linoleic acid metabolic process (GO:0043651)2.98377119
122positive regulation of potassium ion transport (GO:0043268)2.97210059
123fatty acid elongation (GO:0030497)2.97173527
124ethanol oxidation (GO:0006069)2.95757417
125positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93116814
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93116814
127positive regulation of mitotic sister chromatid separation (GO:1901970)2.93116814
128protein localization to cilium (GO:0061512)2.92903000
129cellular modified amino acid catabolic process (GO:0042219)2.92848738
130protein localization to peroxisome (GO:0072662)2.91388271
131protein targeting to peroxisome (GO:0006625)2.91388271
132establishment of protein localization to peroxisome (GO:0072663)2.91388271
133epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.90915000
134negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.88654253
135positive regulation of chromosome segregation (GO:0051984)2.88489970
136regulation of sarcomere organization (GO:0060297)2.87755394
137* regulation of glial cell differentiation (GO:0045685)2.87597023
138behavioral response to nicotine (GO:0035095)2.87299346
139proline biosynthetic process (GO:0006561)2.86531723
140platelet dense granule organization (GO:0060155)2.85943252
141limb development (GO:0060173)2.84287774
142appendage development (GO:0048736)2.84287774
143DNA unwinding involved in DNA replication (GO:0006268)2.82910696
144positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.82569920
145aspartate family amino acid catabolic process (GO:0009068)2.81948439
146positive regulation of circadian rhythm (GO:0042753)2.81619686
147mitotic G2/M transition checkpoint (GO:0044818)2.81595049
148response to folic acid (GO:0051593)2.80800956
149myoblast differentiation (GO:0045445)2.80708635
150pyrimidine dimer repair (GO:0006290)2.79257427
151acrosome assembly (GO:0001675)2.77898315
152spermatid nucleus differentiation (GO:0007289)2.77132118
153regulation of astrocyte differentiation (GO:0048710)2.76898432
154regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76664186
155peroxisome organization (GO:0007031)2.75920361
156regulation of potassium ion transmembrane transport (GO:1901379)2.74752649
157translesion synthesis (GO:0019985)2.74480176
158reflex (GO:0060004)2.74381265
159regulation of mitotic metaphase/anaphase transition (GO:0030071)2.73692976
160* positive regulation of Notch signaling pathway (GO:0045747)2.73319737
161histone H2A acetylation (GO:0043968)2.73098621
162regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.72856660
163thalamus development (GO:0021794)2.72463760
164axonal fasciculation (GO:0007413)2.70715413
165cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.69474382
166positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.68952248
167glial cell migration (GO:0008347)2.68899871
168astrocyte differentiation (GO:0048708)2.68472852
169presynaptic membrane organization (GO:0097090)2.68202482
170C-terminal protein amino acid modification (GO:0018410)2.67919778
171vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.67067885
172central nervous system neuron axonogenesis (GO:0021955)2.65369544
173cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.64660902
174proximal/distal pattern formation (GO:0009954)2.61975768
175mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.59611777
176cilium movement (GO:0003341)2.59107227
177metallo-sulfur cluster assembly (GO:0031163)2.57426366
178iron-sulfur cluster assembly (GO:0016226)2.57426366
179calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.57400365
180sulfur amino acid biosynthetic process (GO:0000097)2.56792931
181regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.56054461
182cell fate commitment involved in formation of primary germ layer (GO:0060795)2.54989405
183cysteine metabolic process (GO:0006534)2.53306654
184neuron cell-cell adhesion (GO:0007158)2.52686501

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.92922729
2EZH2_22144423_ChIP-Seq_EOC_Human6.51372007
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.25593273
4IGF1R_20145208_ChIP-Seq_DFB_Human4.01550744
5ZNF274_21170338_ChIP-Seq_K562_Hela3.17832621
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.76024156
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54312453
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38072103
9ELK1_19687146_ChIP-ChIP_HELA_Human2.37802560
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25689394
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.18798987
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.18239882
13TAF15_26573619_Chip-Seq_HEK293_Human2.16208910
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14837833
15* ERG_21242973_ChIP-ChIP_JURKAT_Human2.09466714
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.01254065
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.98183786
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.94698960
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93612297
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93063576
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92505422
22ZNF263_19887448_ChIP-Seq_K562_Human1.92504251
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92183430
24* EZH2_27304074_Chip-Seq_ESCs_Mouse1.91826534
25* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91530857
26EWS_26573619_Chip-Seq_HEK293_Human1.91257933
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90520359
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87053280
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86884920
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86884920
31TCF3_18692474_ChIP-Seq_MEFs_Mouse1.83124261
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.82101682
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81472860
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.80953818
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78537438
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.77381172
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75456967
38VDR_23849224_ChIP-Seq_CD4+_Human1.75148407
39* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73683921
40AR_21909140_ChIP-Seq_LNCAP_Human1.72204598
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70259336
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.70181633
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68569720
44* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67374276
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.66847515
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65491682
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.64147756
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64016338
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.62844573
50VDR_22108803_ChIP-Seq_LS180_Human1.60101354
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.59116425
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58744516
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58391592
54TP53_20018659_ChIP-ChIP_R1E_Mouse1.56740080
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55358663
56* RING1B_27294783_Chip-Seq_ESCs_Mouse1.53953568
57FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.53715819
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53462084
59SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.53334793
60AR_21572438_ChIP-Seq_LNCaP_Human1.52136908
61P300_19829295_ChIP-Seq_ESCs_Human1.51636910
62* GABP_19822575_ChIP-Seq_HepG2_Human1.50230702
63LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49765825
64REST_21632747_ChIP-Seq_MESCs_Mouse1.48341662
65* RNF2_27304074_Chip-Seq_NSC_Mouse1.46616753
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46521584
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45828339
68* RNF2_27304074_Chip-Seq_ESCs_Mouse1.45511306
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43761596
70* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43722623
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43011021
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42609123
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42183961
74MYC_18940864_ChIP-ChIP_HL60_Human1.42055585
75* RING1B_27294783_Chip-Seq_NPCs_Mouse1.41136771
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.39883979
77* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.38829069
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38104989
79POU5F1_16518401_ChIP-PET_MESCs_Mouse1.36414991
80* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35533460
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35316449
82* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34934533
83* CBX2_27304074_Chip-Seq_ESCs_Mouse1.34397110
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33018108
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32797687
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29677202
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29030634
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28762266
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28518407
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27902744
91CBP_20019798_ChIP-Seq_JUKART_Human1.27902744
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26729994
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.23974321
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23355347
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22290726
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22290726
97FOXP3_21729870_ChIP-Seq_TREG_Human1.22228710
98TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21358504
99* LXR_22292898_ChIP-Seq_THP-1_Human1.21341811
100CTCF_27219007_Chip-Seq_Bcells_Human1.21063897
101* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20453679
102TP53_22573176_ChIP-Seq_HFKS_Human1.18734161
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17048269
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16441438
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.15938800
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15700412
107DCP1A_22483619_ChIP-Seq_HELA_Human1.15193265
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15015782
109FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12518718
110TP63_17297297_ChIP-ChIP_HaCaT_Human1.12414249
111XRN2_22483619_ChIP-Seq_HELA_Human1.12256863
112RARB_27405468_Chip-Seq_BRAIN_Mouse1.11877610
113* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11749508
114TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09422869
115GBX2_23144817_ChIP-Seq_PC3_Human1.08801527
116IRF1_19129219_ChIP-ChIP_H3396_Human1.08773566
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08644637
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08055485
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07683997
120CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05103633
121FUS_26573619_Chip-Seq_HEK293_Human1.04720059
122SMAD4_21799915_ChIP-Seq_A2780_Human1.04598042
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04074527
124SRF_21415370_ChIP-Seq_HL-1_Mouse1.03168027
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02764778
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02368408
127SOX2_22085726_ChIP-Seq_NPCs_Mouse1.02187596
128TTF2_22483619_ChIP-Seq_HELA_Human1.01749226
129AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01360737
130ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98941132
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98718370
132P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98488257
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98483920
134ER_23166858_ChIP-Seq_MCF-7_Human0.98399499
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98340522
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.98204193
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98203545
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.97605170
139E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97533122
140FLI1_21867929_ChIP-Seq_TH2_Mouse0.96472440
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96248489
142CTCF_20526341_ChIP-Seq_ESCs_Human0.96117070
143PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95872918
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95845336
145TET1_21451524_ChIP-Seq_MESCs_Mouse0.95261416
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94315047
147MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93068111
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.92750387
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92183061
150ERG_20517297_ChIP-Seq_VCAP_Human0.91949543
151CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91662674
152PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91645456
153* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91638544
154E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91485833
155DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90248820
156CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90001843
157E2F1_17053090_ChIP-ChIP_MCF-7_Human0.88442957
158SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87912607
159WT1_19549856_ChIP-ChIP_CCG9911_Human0.87244916
160NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86978814
161CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.86334919
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82985394
163NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.81395927
164DROSHA_22980978_ChIP-Seq_HELA_Human0.81154745
165VDR_21846776_ChIP-Seq_THP-1_Human0.79859878
166NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79793741
167MYC_18555785_ChIP-Seq_MESCs_Mouse0.79592320
168SALL1_21062744_ChIP-ChIP_HESCs_Human0.79451673
169TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78839466
170SOX2_18692474_ChIP-Seq_MESCs_Mouse0.77557698
171* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.76532981
172BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76468330
173CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75873269
174CSB_26484114_Chip-Seq_FIBROBLAST_Human0.75776842
175* NANOG_21062744_ChIP-ChIP_HESCs_Human0.75411556
176PHF8_20622854_ChIP-Seq_HELA_Human0.72492548
177MYC_27129775_Chip-Seq_CORNEA_Mouse0.71617015
178RUNX1_26923725_Chip-Seq_HPCs_Mouse0.70532042
179PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.70481486
180GATA6_21074721_ChIP-Seq_CACO-2_Human0.70314054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell8.46799453
2MP0003011_delayed_dark_adaptation5.93802637
3MP0003221_abnormal_cardiomyocyte_apopto4.58787156
4MP0005248_abnormal_Harderian_gland4.45333505
5MP0002009_preneoplasia4.28883634
6MP0003787_abnormal_imprinting3.76752320
7MP0005394_taste/olfaction_phenotype3.44447526
8MP0005499_abnormal_olfactory_system3.44447526
9MP0002877_abnormal_melanocyte_morpholog3.20491912
10MP0003300_gastrointestinal_ulcer3.04590773
11MP0008877_abnormal_DNA_methylation2.94233840
12MP0005645_abnormal_hypothalamus_physiol2.86287634
13MP0003880_abnormal_central_pattern2.84987604
14MP0004264_abnormal_extraembryonic_tissu2.56519243
15MP0002102_abnormal_ear_morphology2.55941991
16MP0004859_abnormal_synaptic_plasticity2.52293814
17MP0003315_abnormal_perineum_morphology2.42781404
18MP0002638_abnormal_pupillary_reflex2.40272644
19MP0002234_abnormal_pharynx_morphology2.33734573
20MP0006292_abnormal_olfactory_placode2.33021209
21MP0006072_abnormal_retinal_apoptosis2.31847224
22MP0004019_abnormal_vitamin_homeostasis2.20533157
23MP0004858_abnormal_nervous_system2.02321126
24MP0003136_yellow_coat_color1.88702048
25MP0000537_abnormal_urethra_morphology1.85507646
26MP0002139_abnormal_hepatobiliary_system1.84146902
27MP0001529_abnormal_vocalization1.81776625
28MP0005167_abnormal_blood-brain_barrier1.78983982
29MP0005187_abnormal_penis_morphology1.78712534
30MP0000631_abnormal_neuroendocrine_gland1.77809100
31MP0010094_abnormal_chromosome_stability1.72018210
32MP0004142_abnormal_muscle_tone1.62102638
33MP0002233_abnormal_nose_morphology1.59085233
34MP0002736_abnormal_nociception_after1.54535028
35MP0005365_abnormal_bile_salt1.52011336
36MP0005253_abnormal_eye_physiology1.49845107
37MP0004742_abnormal_vestibular_system1.44964467
38MP0002909_abnormal_adrenal_gland1.36927961
39MP0003786_premature_aging1.34142389
40MP0003283_abnormal_digestive_organ1.33533164
41MP0000751_myopathy1.32527591
42MP0001664_abnormal_digestion1.32199335
43MP0000778_abnormal_nervous_system1.28983951
44MP0000049_abnormal_middle_ear1.28433097
45MP0005646_abnormal_pituitary_gland1.27249876
46MP0003329_amyloid_beta_deposits1.26615938
47MP0002254_reproductive_system_inflammat1.25366470
48MP0001984_abnormal_olfaction1.23298552
49MP0003122_maternal_imprinting1.22620543
50MP0000566_synostosis1.22119579
51MP0001486_abnormal_startle_reflex1.21698380
52MP0001177_atelectasis1.20351016
53MP0003938_abnormal_ear_development1.20329136
54MP0002095_abnormal_skin_pigmentation1.19945906
55MP0000372_irregular_coat_pigmentation1.19346370
56MP0003635_abnormal_synaptic_transmissio1.18174068
57MP0001270_distended_abdomen1.16902733
58MP0003121_genomic_imprinting1.16284673
59MP0004133_heterotaxia1.15837837
60MP0005171_absent_coat_pigmentation1.13922023
61* MP0002752_abnormal_somatic_nervous1.12040742
62MP0003937_abnormal_limbs/digits/tail_de1.11877765
63MP0002064_seizures1.11376609
64MP0003632_abnormal_nervous_system1.10100830
65MP0010234_abnormal_vibrissa_follicle1.09640795
66MP0008004_abnormal_stomach_pH1.09170989
67MP0000465_gastrointestinal_hemorrhage1.08927200
68MP0009046_muscle_twitch1.08646549
69MP0000762_abnormal_tongue_morphology1.08037163
70MP0003705_abnormal_hypodermis_morpholog1.07766644
71MP0000639_abnormal_adrenal_gland1.06267579
72MP0001764_abnormal_homeostasis1.03651642
73MP0004197_abnormal_fetal_growth/weight/1.03071066
74MP0003878_abnormal_ear_physiology1.01084399
75MP0005377_hearing/vestibular/ear_phenot1.01084399
76MP0005367_renal/urinary_system_phenotyp1.00012603
77MP0000516_abnormal_urinary_system1.00012603
78MP0001502_abnormal_circadian_rhythm0.99750022
79MP0003115_abnormal_respiratory_system0.99188555
80MP0001968_abnormal_touch/_nociception0.98304718
81MP0001293_anophthalmia0.98269504
82MP0000427_abnormal_hair_cycle0.96638821
83MP0010030_abnormal_orbit_morphology0.95627346
84MP0002090_abnormal_vision0.94965792
85MP0002098_abnormal_vibrissa_morphology0.94851943
86MP0008058_abnormal_DNA_repair0.94694806
87MP0000343_altered_response_to0.93906733
88MP0002063_abnormal_learning/memory/cond0.92549261
89MP0002067_abnormal_sensory_capabilities0.91670903
90MP0005391_vision/eye_phenotype0.91347892
91MP0005551_abnormal_eye_electrophysiolog0.90286505
92MP0001286_abnormal_eye_development0.88798586
93MP0006054_spinal_hemorrhage0.87635191
94MP0003634_abnormal_glial_cell0.87630903
95MP0008932_abnormal_embryonic_tissue0.87266019
96MP0002734_abnormal_mechanical_nocicepti0.86605788
97MP0000955_abnormal_spinal_cord0.85720749
98MP0009745_abnormal_behavioral_response0.85705717
99MP0000462_abnormal_digestive_system0.85669123
100MP0001324_abnormal_eye_pigmentation0.83607409
101MP0006276_abnormal_autonomic_nervous0.83123681
102MP0002557_abnormal_social/conspecific_i0.82905162
103MP0001485_abnormal_pinna_reflex0.81131330
104MP0002751_abnormal_autonomic_nervous0.80943492
105* MP0002882_abnormal_neuron_morphology0.80580653
106MP0002697_abnormal_eye_size0.80233004
107MP0003111_abnormal_nucleus_morphology0.80199582
108MP0004811_abnormal_neuron_physiology0.78583898
109MP0003941_abnormal_skin_development0.77391796
110MP0000613_abnormal_salivary_gland0.77159275
111MP0002092_abnormal_eye_morphology0.76707041
112MP0002163_abnormal_gland_morphology0.75406849
113MP0002127_abnormal_cardiovascular_syste0.75216806
114MP0001346_abnormal_lacrimal_gland0.73965619
115MP0006035_abnormal_mitochondrial_morpho0.73946457
116MP0005195_abnormal_posterior_eye0.73936339
117MP0003638_abnormal_response/metabolism_0.72364047
118MP0005595_abnormal_vascular_smooth0.71636159
119MP0009764_decreased_sensitivity_to0.71038793
120MP0003137_abnormal_impulse_conducting0.70041839
121MP0008260_abnormal_autophagy0.69469156
122* MP0002152_abnormal_brain_morphology0.68078186
123MP0001145_abnormal_male_reproductive0.67361545
124MP0002572_abnormal_emotion/affect_behav0.67243728
125MP0003693_abnormal_embryo_hatching0.67228508
126MP0004270_analgesia0.67147657
127MP0003119_abnormal_digestive_system0.66672438
128MP0008995_early_reproductive_senescence0.66636606
129MP0002653_abnormal_ependyma_morphology0.66554393
130MP0001963_abnormal_hearing_physiology0.66499027
131MP0000653_abnormal_sex_gland0.65964379
132MP0003942_abnormal_urinary_system0.65892489
133MP0002249_abnormal_larynx_morphology0.65881749
134MP0003077_abnormal_cell_cycle0.65749048
135MP0002277_abnormal_respiratory_mucosa0.65449806
136MP0000579_abnormal_nail_morphology0.65108875
137MP0004885_abnormal_endolymph0.60914984
138MP0003690_abnormal_glial_cell0.60305925
139MP0002184_abnormal_innervation0.60098987
140MP0000647_abnormal_sebaceous_gland0.59446677
141MP0001970_abnormal_pain_threshold0.58485527
142* MP0003861_abnormal_nervous_system0.58428443
143MP0003755_abnormal_palate_morphology0.57571276
144MP0005379_endocrine/exocrine_gland_phen0.57377392
145MP0000026_abnormal_inner_ear0.56201999
146MP0002282_abnormal_trachea_morphology0.56068399
147MP0005165_increased_susceptibility_to0.55572772
148MP0002733_abnormal_thermal_nociception0.54177283
149MP0001340_abnormal_eyelid_morphology0.54150898
150MP0002066_abnormal_motor_capabilities/c0.51201517
151MP0002166_altered_tumor_susceptibility0.49672483
152MP0004484_altered_response_of0.49315626
153MP0008789_abnormal_olfactory_epithelium0.47850971
154MP0005451_abnormal_body_composition0.47344763
155MP0004215_abnormal_myocardial_fiber0.46663262
156MP0001188_hyperpigmentation0.46478464

Predicted human phenotypes

RankGene SetZ-score
1Severe global developmental delay (HP:0011344)6.42417090
2Death in childhood (HP:0003819)6.10370201
3Porencephaly (HP:0002132)6.04138884
4Megalencephaly (HP:0001355)6.03670741
5Progressive microcephaly (HP:0000253)6.00304941
6Medulloblastoma (HP:0002885)5.31322956
7Cleft eyelid (HP:0000625)4.94668004
8Hepatosplenomegaly (HP:0001433)4.60157236
9Plagiocephaly (HP:0001357)4.55296503
10Delayed CNS myelination (HP:0002188)4.40980504
11Thickened helices (HP:0000391)4.24497638
12Split foot (HP:0001839)4.11215557
13Abnormality of alanine metabolism (HP:0010916)4.09005009
14Hyperalaninemia (HP:0003348)4.09005009
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.09005009
16Ketoacidosis (HP:0001993)4.05821360
17True hermaphroditism (HP:0010459)3.82062659
18Volvulus (HP:0002580)3.78078141
19Calcaneovalgus deformity (HP:0001848)3.65166177
20Pancreatic fibrosis (HP:0100732)3.36593248
21Neoplasm of the adrenal cortex (HP:0100641)3.28779725
22Holoprosencephaly (HP:0001360)3.24922143
23Medial flaring of the eyebrow (HP:0010747)3.20479341
24Abnormality of midbrain morphology (HP:0002418)3.17984009
25Molar tooth sign on MRI (HP:0002419)3.17984009
26Long nose (HP:0003189)3.17488883
27Deformed tarsal bones (HP:0008119)3.15851748
28Abnormality of the parathyroid morphology (HP:0011766)3.09792103
29Pancreatic cysts (HP:0001737)3.05725839
30Congenital primary aphakia (HP:0007707)3.05541114
31Hemivertebrae (HP:0002937)3.04585983
32Polygenic inheritance (HP:0010982)3.03749041
33Gait imbalance (HP:0002141)3.02208789
34Stenosis of the external auditory canal (HP:0000402)3.01205667
35Abnormality of serine family amino acid metabolism (HP:0010894)2.98630118
36Abnormality of glycine metabolism (HP:0010895)2.98630118
37Nervous tissue neoplasm (HP:0030060)2.98041365
38Neuroectodermal neoplasm (HP:0030061)2.98041365
39Neuroepithelial neoplasm (HP:0030063)2.98041365
40Optic nerve hypoplasia (HP:0000609)2.93322822
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.91863923
42Nephrogenic diabetes insipidus (HP:0009806)2.90468512
43Ketosis (HP:0001946)2.89718235
44Abnormality of chromosome segregation (HP:0002916)2.88265974
45Hemorrhage of the eye (HP:0011885)2.85532749
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.84367983
47Hyperglycinuria (HP:0003108)2.84348751
48Colon cancer (HP:0003003)2.83251746
49Increased number of teeth (HP:0011069)2.77099257
50Neurodegeneration (HP:0002180)2.76103232
51Duplicated collecting system (HP:0000081)2.72871933
52Decreased central vision (HP:0007663)2.69632719
53Trigonocephaly (HP:0000243)2.67432167
54Embryonal neoplasm (HP:0002898)2.59122263
55Retinal dysplasia (HP:0007973)2.57540009
56Chromsome breakage (HP:0040012)2.56011292
57Reticulocytopenia (HP:0001896)2.55158735
58Nephronophthisis (HP:0000090)2.53544311
59B lymphocytopenia (HP:0010976)2.53509306
60Abnormality of B cell number (HP:0010975)2.53509306
61Renal dysplasia (HP:0000110)2.52355825
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.51827403
63Neoplasm of striated muscle (HP:0009728)2.51306961
64Glioma (HP:0009733)2.50283377
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.48599176
66Pendular nystagmus (HP:0012043)2.47142244
67Short 4th metacarpal (HP:0010044)2.44863586
68Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44863586
69Neoplasm of the heart (HP:0100544)2.44208103
70Abnormality of the labia minora (HP:0012880)2.43248289
71Postaxial foot polydactyly (HP:0001830)2.43148236
72Abnormality of the renal medulla (HP:0100957)2.41851375
73Type II lissencephaly (HP:0007260)2.41183368
74Methylmalonic acidemia (HP:0002912)2.39307354
75Postaxial hand polydactyly (HP:0001162)2.39140082
76Hypoplastic pelvis (HP:0008839)2.38445621
77Abnormal biliary tract physiology (HP:0012439)2.38099753
78Bile duct proliferation (HP:0001408)2.38099753
79Oligodactyly (hands) (HP:0001180)2.37199639
80Aplasia/Hypoplasia of the tongue (HP:0010295)2.36541091
81Chronic hepatic failure (HP:0100626)2.36085296
82Decreased lacrimation (HP:0000633)2.34905827
83Elfin facies (HP:0004428)2.33351035
84Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.33036089
85Limb-girdle muscle atrophy (HP:0003797)2.31829657
86Epidermoid cyst (HP:0200040)2.29954778
87Acute lymphatic leukemia (HP:0006721)2.29546700
88Genital tract atresia (HP:0001827)2.28931051
89Abnormality of the renal collecting system (HP:0004742)2.27571035
903-Methylglutaconic aciduria (HP:0003535)2.27319760
91Vaginal atresia (HP:0000148)2.25629312
92Neoplasm of the adrenal gland (HP:0100631)2.24844188
93Occipital encephalocele (HP:0002085)2.24454620
94Preaxial hand polydactyly (HP:0001177)2.23075262
95Poor coordination (HP:0002370)2.22920361
96Clumsiness (HP:0002312)2.22837276
97Rimmed vacuoles (HP:0003805)2.21065498
98Anencephaly (HP:0002323)2.18935757
99Sleep apnea (HP:0010535)2.18770460
100Coronal craniosynostosis (HP:0004440)2.18676155
101Drooling (HP:0002307)2.18151855
102Absent/shortened dynein arms (HP:0200106)2.17004055
103Dynein arm defect of respiratory motile cilia (HP:0012255)2.17004055
104Abnormality of the antihelix (HP:0009738)2.16798647
105Abnormality of the fovea (HP:0000493)2.14764762
106Brushfield spots (HP:0001088)2.14627616
107Sclerocornea (HP:0000647)2.13916443
108Increased serum pyruvate (HP:0003542)2.12904375
109Annular pancreas (HP:0001734)2.11393862
110Esophageal atresia (HP:0002032)2.10654395
111Intestinal atresia (HP:0011100)2.10387648
112Short 5th finger (HP:0009237)2.09995055
113Chorioretinal atrophy (HP:0000533)2.07718716
114Increased hepatocellular lipid droplets (HP:0006565)2.07213069
115Abnormality of pyrimidine metabolism (HP:0004353)2.07059578
116Hemiparesis (HP:0001269)2.06191085
117Anterior segment dysgenesis (HP:0007700)2.06014038
118Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.04950965
119Gastrointestinal atresia (HP:0002589)2.03532506
120Lipid accumulation in hepatocytes (HP:0006561)2.03365638
121Malignant neoplasm of the central nervous system (HP:0100836)2.01808300
122Abolished electroretinogram (ERG) (HP:0000550)2.01231757
123Broad alveolar ridges (HP:0000187)1.99644791
124Renal hypoplasia (HP:0000089)1.99379338
125Rhabdomyosarcoma (HP:0002859)1.98533842
126Septo-optic dysplasia (HP:0100842)1.98141613
127Specific learning disability (HP:0001328)1.97388561
128Excessive salivation (HP:0003781)1.96772334
129Cutaneous melanoma (HP:0012056)1.95839484
130Hemiplegia (HP:0002301)1.94893166
131Delayed myelination (HP:0012448)1.94245400
132Renal agenesis (HP:0000104)1.93883479
133Oligodactyly (HP:0012165)1.93245608
134Increased corneal curvature (HP:0100692)1.93146113
135Keratoconus (HP:0000563)1.93146113
136Decreased testicular size (HP:0008734)1.92597893
137Cystic liver disease (HP:0006706)1.92296727
138Neoplasm of the liver (HP:0002896)1.90721700
139Freckling (HP:0001480)1.89693653
140Abnormality of the calcaneus (HP:0008364)1.89674308
141Hypoplasia of the thymus (HP:0000778)1.89361942
142Large for gestational age (HP:0001520)1.88313988
143Hyperammonemia (HP:0001987)1.88243191
144Hepatoblastoma (HP:0002884)1.87086727
145Male pseudohermaphroditism (HP:0000037)1.86777362
146Lissencephaly (HP:0001339)1.84884602
147Alacrima (HP:0000522)1.82847204
148Attenuation of retinal blood vessels (HP:0007843)1.82568960
149Abnormal hemoglobin (HP:0011902)1.82025461
150Broad foot (HP:0001769)1.81634376
151Degeneration of anterior horn cells (HP:0002398)1.81391671
152Abnormality of the anterior horn cell (HP:0006802)1.81391671
153Postnatal microcephaly (HP:0005484)1.81339735
154Aplasia/Hypoplasia of the nipples (HP:0006709)1.80686161
155Joint hemorrhage (HP:0005261)1.80675804
156Hyperglycinemia (HP:0002154)1.80032488
157Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.78701782
158Aganglionic megacolon (HP:0002251)1.78688909
159Neonatal respiratory distress (HP:0002643)1.76654298
160Abnormality of DNA repair (HP:0003254)1.75846759
161Pachygyria (HP:0001302)1.75500400
162Micropenis (HP:0000054)1.75146915
163Abnormal eating behavior (HP:0100738)1.74338093
164Polyphagia (HP:0002591)1.73079853
165Abnormality of the metopic suture (HP:0005556)1.71387935
166Dandy-Walker malformation (HP:0001305)1.71061144
167Aplasia/Hypoplasia of the lens (HP:0008063)1.69793392
168Hypsarrhythmia (HP:0002521)1.69757684
169Posterior subcapsular cataract (HP:0007787)1.69128807
170Short tibia (HP:0005736)1.68847087
171Glossoptosis (HP:0000162)1.68272937
172Median cleft lip (HP:0000161)1.67757065
173Spastic diplegia (HP:0001264)1.67272963
174Aplasia/Hypoplasia of the ulna (HP:0006495)1.67269323
175Dyskinesia (HP:0100660)1.67046478
176Congenital hepatic fibrosis (HP:0002612)1.66974484
177Scanning speech (HP:0002168)1.65607680
178Down-sloping shoulders (HP:0200021)1.65542069
179Abnormality of the 4th metacarpal (HP:0010012)1.63311395
180Shoulder girdle muscle weakness (HP:0003547)1.62678812
181Conjunctival telangiectasia (HP:0000524)1.61710548
182Seborrheic dermatitis (HP:0001051)1.60985366
183Focal motor seizures (HP:0011153)1.60294188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K66.09951637
2MAP3K45.03510376
3LMTK25.01334528
4MAP2K74.61391998
5SRPK13.33950796
6MAP4K23.22739823
7MAP2K43.10123269
8PRKD32.98220153
9CDK62.92624306
10TRIM282.62930142
11CCNB12.47297034
12ERBB32.30495527
13NEK92.29005146
14PIM22.27328707
15EPHA42.26180067
16NTRK22.22440769
17PHKG22.12647230
18PHKG12.12647230
19BCR2.10029655
20PRPF4B2.03683882
21WNK31.99495131
22TRIB31.98648147
23PLK21.91166589
24DYRK1B1.78035292
25PIK3CG1.75680469
26CDK41.68732283
27CDC71.65253860
28CDK31.61577587
29CDK191.57360989
30PBK1.56278176
31MKNK21.54412066
32LRRK21.52706920
33MAP3K121.47386968
34FGR1.45618026
35EIF2AK31.38856337
36CDK151.38269785
37CDK181.37439303
38PRKD21.36594005
39CDK11A1.32008054
40DYRK31.27518586
41CDK91.24535368
42SIK11.19065127
43MAPK41.18749420
44PLK41.18732341
45TAOK31.18509269
46CDK141.15744809
47NUAK11.10390527
48RPS6KA41.10380889
49PAK61.09843551
50CHEK21.06292493
51MAP3K101.04511239
52UHMK11.04412881
53BUB11.04047933
54YES10.99707722
55EPHB20.99537935
56NEK10.95515146
57CSNK1G30.95511445
58PLK10.95416487
59ATR0.95305583
60BMPR1B0.95079807
61VRK20.92834184
62CSNK1A1L0.91357373
63BCKDK0.90698497
64ADRBK10.89943424
65MAP3K50.88889654
66CDK50.87421652
67STK390.86544848
68INSRR0.86345946
69LIMK10.85579818
70PLK30.84543267
71WEE10.81388030
72PKN10.81315496
73BRD40.81010829
74CSNK1A10.76782247
75BRSK20.76116032
76WNK40.74154050
77FGFR20.73534772
78MKNK10.71583416
79CSNK1G10.68261574
80ZAK0.67875584
81VRK10.67581609
82CSNK1G20.67466509
83ROCK20.66349418
84PINK10.65605507
85RET0.65560964
86IRAK10.65190642
87AURKB0.64071254
88STK380.61772778
89SIK30.61750670
90MINK10.60085446
91GRK10.59333387
92PAK40.57944838
93PRKCH0.57904086
94MOS0.56888736
95SGK2230.56671582
96SGK4940.56671582
97DYRK20.55741025
98ICK0.55557931
99MAPKAPK20.55244022
100MARK10.54233295
101CASK0.53320735
102MAPK130.53049073
103NME10.52931800
104ERBB40.51980233
105ABL20.49629941
106PRKCE0.47468701
107PASK0.47100927
108RPS6KA50.46424373
109CAMK2A0.44531765
110EPHB10.44188402
111STK38L0.43937502
112DDR20.43779305
113AKT20.42668722
114MAPK90.40383002
115PRKDC0.39643182
116TAOK20.39438738
117BRSK10.38912699
118GRK60.37975202
119EPHA20.36666431
120DAPK10.36664666
121EPHA30.36432732
122ERBB20.36170002
123PDK30.35400249
124PDK40.35400249
125EIF2AK20.33503822
126FRK0.32200852
127CSNK1D0.31929433
128TTK0.31532282
129TYRO30.31405468
130ATM0.28813182
131EGFR0.28699860
132LATS10.28331827
133CSNK2A10.27150378
134CAMK2B0.26834620
135STK100.26751220
136ACVR1B0.26566440
137STK160.26560503
138OXSR10.26196928
139ABL10.25978905
140TESK20.25607160
141ALK0.25191888
142PRKACA0.24045579
143MUSK0.23940174
144MAPK150.20649357
145FER0.19419217
146PRKCG0.18426833
147NTRK30.18024029
148PAK30.16442283
149CDK20.16245646
150HIPK20.16093235
151CSK0.15875674
152MAPK80.15620169
153FYN0.15026995
154CHEK10.14776159
155MAPK100.14664020
156MST40.14638698
157CDK10.12521966

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030307.80888820
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.61246185
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005634.53242986
4Mismatch repair_Homo sapiens_hsa034303.81900518
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51213752
6Nucleotide excision repair_Homo sapiens_hsa034202.48207924
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.29159854
8Homologous recombination_Homo sapiens_hsa034402.22861673
9Fatty acid biosynthesis_Homo sapiens_hsa000612.20977566
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.17584920
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16243186
12Cell cycle_Homo sapiens_hsa041102.05146963
13Butanoate metabolism_Homo sapiens_hsa006502.04342131
14Propanoate metabolism_Homo sapiens_hsa006402.04248761
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99093229
16Fatty acid metabolism_Homo sapiens_hsa012121.97688835
17Protein export_Homo sapiens_hsa030601.91406441
18Fatty acid degradation_Homo sapiens_hsa000711.87095573
19Basal transcription factors_Homo sapiens_hsa030221.86446099
20Type I diabetes mellitus_Homo sapiens_hsa049401.83261149
21Base excision repair_Homo sapiens_hsa034101.74670813
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.70671716
23Steroid biosynthesis_Homo sapiens_hsa001001.64168207
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43806617
25Hedgehog signaling pathway_Homo sapiens_hsa043401.34256549
26Proteasome_Homo sapiens_hsa030501.32414147
27Arginine and proline metabolism_Homo sapiens_hsa003301.30332220
28p53 signaling pathway_Homo sapiens_hsa041151.23257590
29Biosynthesis of amino acids_Homo sapiens_hsa012301.21738882
30Malaria_Homo sapiens_hsa051441.21416585
31Oxidative phosphorylation_Homo sapiens_hsa001901.17306974
32Regulation of autophagy_Homo sapiens_hsa041401.15555090
33Parkinsons disease_Homo sapiens_hsa050121.14592546
34beta-Alanine metabolism_Homo sapiens_hsa004101.11857184
35RNA polymerase_Homo sapiens_hsa030201.09447974
36Pyruvate metabolism_Homo sapiens_hsa006201.08115682
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05908443
38Huntingtons disease_Homo sapiens_hsa050161.05368116
39Fatty acid elongation_Homo sapiens_hsa000621.03671208
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99802814
41Vitamin digestion and absorption_Homo sapiens_hsa049770.97611403
42Notch signaling pathway_Homo sapiens_hsa043300.96442274
43Basal cell carcinoma_Homo sapiens_hsa052170.94249744
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93929773
45Tryptophan metabolism_Homo sapiens_hsa003800.93443280
46Linoleic acid metabolism_Homo sapiens_hsa005910.93219400
47GABAergic synapse_Homo sapiens_hsa047270.90778192
48RNA transport_Homo sapiens_hsa030130.90443190
49Sulfur relay system_Homo sapiens_hsa041220.89127728
50Bladder cancer_Homo sapiens_hsa052190.88597494
51Oocyte meiosis_Homo sapiens_hsa041140.88595883
52Morphine addiction_Homo sapiens_hsa050320.86637182
53Pyrimidine metabolism_Homo sapiens_hsa002400.85979677
54Nitrogen metabolism_Homo sapiens_hsa009100.84793553
55Nicotine addiction_Homo sapiens_hsa050330.84655198
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82847660
57ErbB signaling pathway_Homo sapiens_hsa040120.82163078
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79718858
59Axon guidance_Homo sapiens_hsa043600.79430315
60Non-homologous end-joining_Homo sapiens_hsa034500.79418554
61PPAR signaling pathway_Homo sapiens_hsa033200.77071070
62Carbon metabolism_Homo sapiens_hsa012000.76660743
63Glutamatergic synapse_Homo sapiens_hsa047240.75188629
64Vitamin B6 metabolism_Homo sapiens_hsa007500.73219569
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.70402394
66Salivary secretion_Homo sapiens_hsa049700.64715129
67Glucagon signaling pathway_Homo sapiens_hsa049220.64447542
68GnRH signaling pathway_Homo sapiens_hsa049120.63931593
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62926505
70VEGF signaling pathway_Homo sapiens_hsa043700.62611925
71Melanogenesis_Homo sapiens_hsa049160.61820268
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.60403851
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60390990
74RNA degradation_Homo sapiens_hsa030180.60227405
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59764070
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58385877
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57975502
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57574026
79Sulfur metabolism_Homo sapiens_hsa009200.57427336
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.56922813
81Ether lipid metabolism_Homo sapiens_hsa005650.56912753
82Fanconi anemia pathway_Homo sapiens_hsa034600.56885970
83Pentose phosphate pathway_Homo sapiens_hsa000300.56551192
84Lysine degradation_Homo sapiens_hsa003100.56518993
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.55867067
86Dopaminergic synapse_Homo sapiens_hsa047280.55826961
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55161729
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55006515
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.54837494
90Wnt signaling pathway_Homo sapiens_hsa043100.51215755
91Gastric acid secretion_Homo sapiens_hsa049710.51041203
92Fat digestion and absorption_Homo sapiens_hsa049750.49677280
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49416647
94Shigellosis_Homo sapiens_hsa051310.46692542
95Alzheimers disease_Homo sapiens_hsa050100.45115923
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.44038891
97mRNA surveillance pathway_Homo sapiens_hsa030150.43117283
98Purine metabolism_Homo sapiens_hsa002300.42262722
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42211967
100Complement and coagulation cascades_Homo sapiens_hsa046100.40842922
101Spliceosome_Homo sapiens_hsa030400.40688759
102Arachidonic acid metabolism_Homo sapiens_hsa005900.40022812
103Glycerolipid metabolism_Homo sapiens_hsa005610.39234943
104Glioma_Homo sapiens_hsa052140.39217786
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37366974
106Alcoholism_Homo sapiens_hsa050340.35922869
107Long-term depression_Homo sapiens_hsa047300.35262389
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.34609470
109Circadian entrainment_Homo sapiens_hsa047130.32559187
110Retinol metabolism_Homo sapiens_hsa008300.32544068
111Insulin secretion_Homo sapiens_hsa049110.32106250
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31092770
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30341159
114Insulin signaling pathway_Homo sapiens_hsa049100.29413849
115Olfactory transduction_Homo sapiens_hsa047400.29062808
116Pancreatic cancer_Homo sapiens_hsa052120.28345015
117HTLV-I infection_Homo sapiens_hsa051660.27514469
118Cocaine addiction_Homo sapiens_hsa050300.27032890
119Folate biosynthesis_Homo sapiens_hsa007900.25917624
120Bile secretion_Homo sapiens_hsa049760.24923190
121Hepatitis B_Homo sapiens_hsa051610.24344462
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24017633
123AMPK signaling pathway_Homo sapiens_hsa041520.23893849
124Starch and sucrose metabolism_Homo sapiens_hsa005000.22479759
125cAMP signaling pathway_Homo sapiens_hsa040240.22332563
126Cardiac muscle contraction_Homo sapiens_hsa042600.22306215
127Insulin resistance_Homo sapiens_hsa049310.22273754
128Viral carcinogenesis_Homo sapiens_hsa052030.21839221
129Phototransduction_Homo sapiens_hsa047440.21445874
130Synaptic vesicle cycle_Homo sapiens_hsa047210.21385883
131Selenocompound metabolism_Homo sapiens_hsa004500.21373633
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21309540
133Type II diabetes mellitus_Homo sapiens_hsa049300.21081841
134Metabolic pathways_Homo sapiens_hsa011000.20885360
135Circadian rhythm_Homo sapiens_hsa047100.20771203
136Peroxisome_Homo sapiens_hsa041460.20755435
137Hippo signaling pathway_Homo sapiens_hsa043900.20541645
138Histidine metabolism_Homo sapiens_hsa003400.18879439
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17241861
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16996181
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15998838
142Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.15083699
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14589939

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