GTDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.24200648
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.87722203
3regulation of meiosis I (GO:0060631)4.72035596
4piRNA metabolic process (GO:0034587)4.54158011
5behavioral response to nicotine (GO:0035095)4.13113061
6neuron cell-cell adhesion (GO:0007158)4.01689991
7neurotransmitter-gated ion channel clustering (GO:0072578)3.97316668
8regulation of meiosis (GO:0040020)3.93488240
9negative regulation of hormone metabolic process (GO:0032351)3.83473533
10negative regulation of hormone biosynthetic process (GO:0032353)3.83473533
11synaptic vesicle maturation (GO:0016188)3.79259447
12righting reflex (GO:0060013)3.70792130
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.70690306
14meiotic chromosome segregation (GO:0045132)3.67791460
15gamma-aminobutyric acid transport (GO:0015812)3.62787446
16neural tube formation (GO:0001841)3.53544947
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51448268
18male meiosis (GO:0007140)3.47504867
19membrane depolarization during action potential (GO:0086010)3.47068235
20presynaptic membrane assembly (GO:0097105)3.46489984
21positive regulation of meiosis (GO:0045836)3.46253206
22postsynaptic membrane organization (GO:0001941)3.43322206
23protein localization to synapse (GO:0035418)3.42248099
24regulation of meiotic cell cycle (GO:0051445)3.38552532
25glutamate receptor signaling pathway (GO:0007215)3.36773928
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34942419
27neuronal action potential (GO:0019228)3.34321315
28negative regulation of cytosolic calcium ion concentration (GO:0051481)3.33315291
29positive regulation of meiotic cell cycle (GO:0051446)3.33192302
30G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.31147239
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.30167111
32female gonad development (GO:0008585)3.28100666
33regulation of short-term neuronal synaptic plasticity (GO:0048172)3.27867923
34female gamete generation (GO:0007292)3.27522776
35negative regulation of meiosis (GO:0045835)3.22469911
36maturation of 5.8S rRNA (GO:0000460)3.22030957
37fucose catabolic process (GO:0019317)3.16351031
38L-fucose metabolic process (GO:0042354)3.16351031
39L-fucose catabolic process (GO:0042355)3.16351031
40negative regulation of keratinocyte proliferation (GO:0010839)3.16234502
41positive regulation of membrane potential (GO:0045838)3.15493925
42transmission of nerve impulse (GO:0019226)3.13866537
43mitotic metaphase plate congression (GO:0007080)3.11112888
44microtubule depolymerization (GO:0007019)3.10758520
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.10712783
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.07551554
47synaptic vesicle endocytosis (GO:0048488)3.04447250
48DNA methylation involved in gamete generation (GO:0043046)3.03677027
49retinal cone cell development (GO:0046549)3.03417243
50serotonin metabolic process (GO:0042428)3.02417924
51positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.00685355
52protein localization to cilium (GO:0061512)3.00124425
53regulation of glutamate receptor signaling pathway (GO:1900449)3.00056086
54vocalization behavior (GO:0071625)2.97552906
55synaptic vesicle exocytosis (GO:0016079)2.97383737
56regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.97014859
57central nervous system myelination (GO:0022010)2.96469305
58axon ensheathment in central nervous system (GO:0032291)2.96469305
59glutamate secretion (GO:0014047)2.93527850
60regulation of synaptic vesicle transport (GO:1902803)2.92668447
61attachment of spindle microtubules to kinetochore (GO:0008608)2.91119192
62synaptic transmission, glutamatergic (GO:0035249)2.90177489
63presynaptic membrane organization (GO:0097090)2.89824923
64proline transport (GO:0015824)2.89374051
65oocyte maturation (GO:0001556)2.88044205
66neurotransmitter uptake (GO:0001504)2.87428364
67metaphase plate congression (GO:0051310)2.86783723
68regulation of mitotic spindle checkpoint (GO:1903504)2.86501841
69regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86501841
70glycerophospholipid catabolic process (GO:0046475)2.85529812
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.84979145
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84836935
73regulation of exit from mitosis (GO:0007096)2.84580238
74regulation of synaptic vesicle exocytosis (GO:2000300)2.83528684
75regulation of synapse maturation (GO:0090128)2.82909827
76mitotic sister chromatid cohesion (GO:0007064)2.82542983
77cyclic nucleotide catabolic process (GO:0009214)2.79676479
78serotonin receptor signaling pathway (GO:0007210)2.78916196
79gamma-aminobutyric acid signaling pathway (GO:0007214)2.78440568
80potassium ion import (GO:0010107)2.77910421
81monoubiquitinated protein deubiquitination (GO:0035520)2.77063804
82primary amino compound metabolic process (GO:1901160)2.76466552
83pyrimidine nucleobase catabolic process (GO:0006208)2.76035974
84detection of light stimulus involved in sensory perception (GO:0050962)2.75243900
85detection of light stimulus involved in visual perception (GO:0050908)2.75243900
86establishment of chromosome localization (GO:0051303)2.73364272
87nerve growth factor signaling pathway (GO:0038180)2.73154911
88synaptic vesicle docking involved in exocytosis (GO:0016081)2.72524100
89neuron-neuron synaptic transmission (GO:0007270)2.72329983
90cerebral cortex radially oriented cell migration (GO:0021799)2.72084844
91positive regulation of DNA-dependent DNA replication (GO:2000105)2.71853860
92negative regulation of neurotransmitter transport (GO:0051589)2.71667827
93neuronal action potential propagation (GO:0019227)2.70050430
94regulation of synapse structural plasticity (GO:0051823)2.69996147
95negative regulation of mast cell activation (GO:0033004)2.68517677
96cerebellar Purkinje cell differentiation (GO:0021702)2.68161003
97startle response (GO:0001964)2.67586934
98cAMP catabolic process (GO:0006198)2.67434464
99regulation of germinal center formation (GO:0002634)2.67013271
100meiotic cell cycle (GO:0051321)2.66775859
101regulation of neurotransmitter uptake (GO:0051580)2.66614265
102membrane depolarization (GO:0051899)2.66560751
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65588606
104negative regulation of homotypic cell-cell adhesion (GO:0034111)2.65369134
105locomotory exploration behavior (GO:0035641)2.63988827
106protein K6-linked ubiquitination (GO:0085020)2.62265075
107regulation of synaptic transmission, glutamatergic (GO:0051966)2.60972329
108phosphorelay signal transduction system (GO:0000160)2.60116064
109centriole replication (GO:0007099)2.59842203
110positive regulation of neurotransmitter secretion (GO:0001956)2.59754995
111positive regulation of megakaryocyte differentiation (GO:0045654)2.59387820
112regulation of voltage-gated calcium channel activity (GO:1901385)2.58993437
113sister chromatid cohesion (GO:0007062)2.58162946
114action potential (GO:0001508)2.57483676
115positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.56005879
116indole-containing compound catabolic process (GO:0042436)2.55548450
117indolalkylamine catabolic process (GO:0046218)2.55548450
118tryptophan catabolic process (GO:0006569)2.55548450
119negative regulation of response to food (GO:0032096)2.55536695
120negative regulation of appetite (GO:0032099)2.55536695
121male meiosis I (GO:0007141)2.54330256
122behavioral response to ethanol (GO:0048149)2.52559300
123centriole assembly (GO:0098534)2.52087175
124indole-containing compound metabolic process (GO:0042430)2.51391402
125neurotransmitter secretion (GO:0007269)2.49617812
126regulation of female gonad development (GO:2000194)2.48766049
127negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.48560209
128indolalkylamine metabolic process (GO:0006586)2.48371476
129central nervous system projection neuron axonogenesis (GO:0021952)2.48087875
130positive regulation of protein sumoylation (GO:0033235)2.47951703
131microtubule polymerization or depolymerization (GO:0031109)2.47532034
132generation of neurons (GO:0048699)2.46883238
133regulation of excitatory postsynaptic membrane potential (GO:0060079)2.46676946
134type B pancreatic cell development (GO:0003323)2.45780172
135regulation of neurotransmitter transport (GO:0051588)2.45536784
136potassium ion transmembrane transport (GO:0071805)2.45472120
137cellular potassium ion transport (GO:0071804)2.45472120
138dentate gyrus development (GO:0021542)2.45347078
139C4-dicarboxylate transport (GO:0015740)2.45058906
140detection of mechanical stimulus involved in sensory perception (GO:0050974)2.43171842
141kynurenine metabolic process (GO:0070189)2.43108310
142adult walking behavior (GO:0007628)2.42556319
143positive regulation of cAMP-mediated signaling (GO:0043950)2.42528249
144nucleobase catabolic process (GO:0046113)2.42300684
145regulation of transforming growth factor beta2 production (GO:0032909)2.42024968
146microtubule nucleation (GO:0007020)2.42012089
147glycosphingolipid biosynthetic process (GO:0006688)2.41923428
148neuromuscular synaptic transmission (GO:0007274)2.41782777
149regulation of long-term neuronal synaptic plasticity (GO:0048169)2.41015951
150protein polyglutamylation (GO:0018095)2.39393804
151behavioral fear response (GO:0001662)2.38993476
152behavioral defense response (GO:0002209)2.38993476
153L-amino acid import (GO:0043092)2.38165564
154positive regulation of potassium ion transmembrane transport (GO:1901381)2.38103328
155kinetochore assembly (GO:0051382)2.38057876
156negative regulation of heart rate (GO:0010459)2.37660553
157protein K11-linked deubiquitination (GO:0035871)2.37470946
158regulation of postsynaptic membrane potential (GO:0060078)2.35822543
159dendrite development (GO:0016358)2.35384726
160potassium ion transport (GO:0006813)2.34222598
161regulation of neurotransmitter secretion (GO:0046928)2.34020308
162response to amphetamine (GO:0001975)2.33884536
163regulation of dendritic spine development (GO:0060998)2.33883268
164platelet dense granule organization (GO:0060155)2.32939806
165regulation of neurotransmitter levels (GO:0001505)2.32865241
166regulation of neuronal synaptic plasticity (GO:0048168)2.32744406
167long-term memory (GO:0007616)2.31579107
168reciprocal meiotic recombination (GO:0007131)2.31101357
169reciprocal DNA recombination (GO:0035825)2.31101357
170interkinetic nuclear migration (GO:0022027)2.30593279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.39156994
2GBX2_23144817_ChIP-Seq_PC3_Human3.70382110
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.30372769
4ZNF274_21170338_ChIP-Seq_K562_Hela2.71706925
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58633558
6* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50849713
7SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.48691197
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.46019035
9* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27375433
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.26255024
11TAF15_26573619_Chip-Seq_HEK293_Human2.18190636
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11620044
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.05448670
14* FUS_26573619_Chip-Seq_HEK293_Human2.05328748
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00744815
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93337125
17* P300_19829295_ChIP-Seq_ESCs_Human1.89159155
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87698952
19RNF2_27304074_Chip-Seq_NSC_Mouse1.87124729
20* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86084784
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81207739
22SMAD4_21799915_ChIP-Seq_A2780_Human1.79165932
23* NANOG_18555785_Chip-Seq_ESCs_Mouse1.75716056
24* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.69730437
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69701793
26TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69701793
27CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69585655
28AR_21572438_ChIP-Seq_LNCaP_Human1.69312956
29EWS_26573619_Chip-Seq_HEK293_Human1.68773123
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67720929
31* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67184001
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.67135980
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66610665
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.66103650
35IGF1R_20145208_ChIP-Seq_DFB_Human1.65207936
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64543394
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.63122087
38STAT3_23295773_ChIP-Seq_U87_Human1.62476971
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61998753
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61363864
41* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61165356
42REST_21632747_ChIP-Seq_MESCs_Mouse1.60574269
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57705169
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54062647
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53902652
46* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53836383
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.49632655
48* E2F1_18555785_Chip-Seq_ESCs_Mouse1.47866337
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47713434
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47317618
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47317618
52* PIAS1_25552417_ChIP-Seq_VCAP_Human1.46838470
53BCAT_22108803_ChIP-Seq_LS180_Human1.45217576
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.44305164
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.43948025
56LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43928737
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43727716
58* P53_22387025_ChIP-Seq_ESCs_Mouse1.43376429
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42429170
60* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41599189
61* CBP_20019798_ChIP-Seq_JUKART_Human1.41599189
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.41145510
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.40791190
64* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.40563791
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40495031
66AR_25329375_ChIP-Seq_VCAP_Human1.40125941
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38879335
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38046259
69* CMYC_18555785_Chip-Seq_ESCs_Mouse1.37935839
70* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.37928349
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.37469078
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37147415
73DROSHA_22980978_ChIP-Seq_HELA_Human1.35559379
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.34660293
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.32353945
76SOX2_18555785_Chip-Seq_ESCs_Mouse1.31977737
77* TCF4_23295773_ChIP-Seq_U87_Human1.30924763
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30709948
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30659618
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30428403
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.30046774
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29525382
83* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29137746
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.28303287
85* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28260813
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27801850
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.26186957
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26002831
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24972928
90SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22259835
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.21952867
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21304473
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21283622
94KDM2B_26808549_Chip-Seq_REH_Human1.21179194
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21169692
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.21138040
97* P300_18555785_Chip-Seq_ESCs_Mouse1.20153225
98* NANOG_19829295_ChIP-Seq_ESCs_Human1.19058348
99* SOX2_19829295_ChIP-Seq_ESCs_Human1.19058348
100KAP1_22055183_ChIP-Seq_ESCs_Mouse1.18968202
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.17679722
102* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17323196
103ER_23166858_ChIP-Seq_MCF-7_Human1.17132538
104* OCT4_18555785_Chip-Seq_ESCs_Mouse1.16903736
105VDR_22108803_ChIP-Seq_LS180_Human1.15668943
106* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15061030
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.14869182
108RUNX2_22187159_ChIP-Seq_PCA_Human1.14659812
109* ZFX_18555785_Chip-Seq_ESCs_Mouse1.13714466
110CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13112104
111STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12744949
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.12651945
113* KLF4_18555785_Chip-Seq_ESCs_Mouse1.12623003
114* SOX2_21211035_ChIP-Seq_LN229_Gbm1.12152954
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12149089
116TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12101753
117CTCF_18555785_Chip-Seq_ESCs_Mouse1.11980798
118TCF4_22108803_ChIP-Seq_LS180_Human1.10660243
119REST_18959480_ChIP-ChIP_MESCs_Mouse1.10484469
120TP53_16413492_ChIP-PET_HCT116_Human1.09975132
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09530673
122IRF1_19129219_ChIP-ChIP_H3396_Human1.09386330
123HTT_18923047_ChIP-ChIP_STHdh_Human1.09243483
124PU1_27457419_Chip-Seq_LIVER_Mouse1.08887888
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08188489
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07553078
127SMAD4_21741376_ChIP-Seq_EPCs_Human1.06589801
128* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06325147
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05784831
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05711615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.92978590
2MP0002102_abnormal_ear_morphology3.76137604
3MP0003787_abnormal_imprinting3.67966503
4MP0004859_abnormal_synaptic_plasticity3.60963241
5MP0006292_abnormal_olfactory_placode3.21067192
6MP0005646_abnormal_pituitary_gland2.87437300
7MP0008877_abnormal_DNA_methylation2.78091715
8MP0003635_abnormal_synaptic_transmissio2.52460250
9MP0000566_synostosis2.49287265
10MP0000569_abnormal_digit_pigmentation2.33408008
11MP0003646_muscle_fatigue2.25681492
12MP0001486_abnormal_startle_reflex2.23251836
13MP0004270_analgesia2.22519018
14MP0004885_abnormal_endolymph2.16709583
15MP0002063_abnormal_learning/memory/cond2.09598155
16MP0001188_hyperpigmentation2.08511043
17MP0009745_abnormal_behavioral_response2.06352654
18MP0001968_abnormal_touch/_nociception1.98516467
19MP0002572_abnormal_emotion/affect_behav1.89819389
20MP0005645_abnormal_hypothalamus_physiol1.86792779
21MP0001529_abnormal_vocalization1.86516173
22MP0003121_genomic_imprinting1.84507559
23MP0010386_abnormal_urinary_bladder1.83263159
24MP0002734_abnormal_mechanical_nocicepti1.83262440
25MP0004142_abnormal_muscle_tone1.83138615
26MP0003718_maternal_effect1.80146419
27MP0004043_abnormal_pH_regulation1.76263586
28MP0005451_abnormal_body_composition1.75516301
29MP0002736_abnormal_nociception_after1.75478549
30MP0008872_abnormal_physiological_respon1.70046187
31MP0009046_muscle_twitch1.65341116
32MP0002735_abnormal_chemical_nociception1.62568211
33MP0002064_seizures1.62150095
34MP0002272_abnormal_nervous_system1.58598514
35MP0001501_abnormal_sleep_pattern1.58468571
36MP0003195_calcinosis1.57844609
37MP0001502_abnormal_circadian_rhythm1.55314684
38MP0005423_abnormal_somatic_nervous1.54963850
39MP0002067_abnormal_sensory_capabilities1.53661262
40MP0001485_abnormal_pinna_reflex1.53459790
41MP0000778_abnormal_nervous_system1.52471475
42MP0005167_abnormal_blood-brain_barrier1.51504697
43MP0002184_abnormal_innervation1.49166495
44MP0004130_abnormal_muscle_cell1.48022042
45MP0001986_abnormal_taste_sensitivity1.45401730
46MP0003123_paternal_imprinting1.43512201
47MP0005174_abnormal_tail_pigmentation1.42480106
48MP0003633_abnormal_nervous_system1.40176676
49MP0002837_dystrophic_cardiac_calcinosis1.40003548
50MP0004215_abnormal_myocardial_fiber1.39644145
51MP0001929_abnormal_gametogenesis1.36890134
52MP0001984_abnormal_olfaction1.36452442
53MP0006276_abnormal_autonomic_nervous1.36319374
54MP0005253_abnormal_eye_physiology1.32146116
55MP0001440_abnormal_grooming_behavior1.27183035
56MP0002210_abnormal_sex_determination1.26297872
57MP0002653_abnormal_ependyma_morphology1.25936775
58MP0003183_abnormal_peptide_metabolism1.23833448
59MP0003111_abnormal_nucleus_morphology1.19591493
60MP0005386_behavior/neurological_phenoty1.19490302
61MP0004924_abnormal_behavior1.19490302
62MP0004147_increased_porphyrin_level1.18222547
63MP0005551_abnormal_eye_electrophysiolog1.17820466
64MP0002557_abnormal_social/conspecific_i1.17591417
65MP0010094_abnormal_chromosome_stability1.17480675
66MP0002249_abnormal_larynx_morphology1.16667983
67MP0001119_abnormal_female_reproductive1.15440760
68MP0001905_abnormal_dopamine_level1.15244658
69MP0000631_abnormal_neuroendocrine_gland1.14484105
70MP0003724_increased_susceptibility_to1.14468319
71MP0001963_abnormal_hearing_physiology1.14003737
72MP0003693_abnormal_embryo_hatching1.13281089
73MP0003698_abnormal_male_reproductive1.12995722
74MP0000653_abnormal_sex_gland1.11118773
75MP0000026_abnormal_inner_ear1.08226025
76MP0004742_abnormal_vestibular_system1.07781704
77MP0001970_abnormal_pain_threshold1.07469703
78MP0003937_abnormal_limbs/digits/tail_de1.06202227
79MP0003631_nervous_system_phenotype1.05503652
80MP0003890_abnormal_embryonic-extraembry1.03482677
81MP0008058_abnormal_DNA_repair1.03158989
82MP0000579_abnormal_nail_morphology1.02833086
83MP0002876_abnormal_thyroid_physiology1.02006220
84MP0002229_neurodegeneration0.99723050
85MP0002163_abnormal_gland_morphology0.98610095
86MP0000230_abnormal_systemic_arterial0.98116164
87MP0003879_abnormal_hair_cell0.97669972
88MP0009764_decreased_sensitivity_to0.96049370
89MP0000955_abnormal_spinal_cord0.95905660
90MP0005499_abnormal_olfactory_system0.94822356
91MP0005394_taste/olfaction_phenotype0.94822356
92MP0003699_abnormal_female_reproductive0.94740437
93MP0008569_lethality_at_weaning0.94441163
94MP0002882_abnormal_neuron_morphology0.93189436
95MP0004484_altered_response_of0.93030447
96MP0000427_abnormal_hair_cycle0.92940900
97MP0005379_endocrine/exocrine_gland_phen0.92327904
98MP0008789_abnormal_olfactory_epithelium0.92192366
99MP0002733_abnormal_thermal_nociception0.90795092
100MP0003011_delayed_dark_adaptation0.90755287
101MP0002752_abnormal_somatic_nervous0.90116805
102MP0009250_abnormal_appendicular_skeleto0.88918765
103MP0001145_abnormal_male_reproductive0.88277724
104MP0003755_abnormal_palate_morphology0.86367731
105MP0003938_abnormal_ear_development0.86337628
106MP0005464_abnormal_platelet_physiology0.86172143
107MP0002152_abnormal_brain_morphology0.85133898
108MP0005671_abnormal_response_to0.84261736
109MP0004145_abnormal_muscle_electrophysio0.83375337
110MP0005084_abnormal_gallbladder_morpholo0.82929667
111MP0005171_absent_coat_pigmentation0.82876258
112MP0002161_abnormal_fertility/fecundity0.81848166
113MP0002066_abnormal_motor_capabilities/c0.81452075
114MP0001177_atelectasis0.81018873
115MP0000015_abnormal_ear_pigmentation0.79819107
116MP0000383_abnormal_hair_follicle0.79740610
117MP0006072_abnormal_retinal_apoptosis0.79159228
118MP0003861_abnormal_nervous_system0.76604253
119MP0004510_myositis0.74740516
120MP0000920_abnormal_myelination0.74559634
121MP0004811_abnormal_neuron_physiology0.74304753
122MP0004084_abnormal_cardiac_muscle0.73639746
123MP0002116_abnormal_craniofacial_bone0.72843481
124MP0002638_abnormal_pupillary_reflex0.72749835
125MP0002909_abnormal_adrenal_gland0.72658520
126MP0008260_abnormal_autophagy0.71480089
127MP0001346_abnormal_lacrimal_gland0.69589266
128MP0003690_abnormal_glial_cell0.69537036
129MP0003315_abnormal_perineum_morphology0.69335968
130MP0000538_abnormal_urinary_bladder0.68983696
131MP0003077_abnormal_cell_cycle0.68620600
132MP0004085_abnormal_heartbeat0.67967929
133MP0003136_yellow_coat_color0.67720269
134MP0002751_abnormal_autonomic_nervous0.66759557
135MP0005395_other_phenotype0.65840379
136MP0005535_abnormal_body_temperature0.65687429
137MP0003632_abnormal_nervous_system0.64497773
138MP0002822_catalepsy0.64494654
139MP0000372_irregular_coat_pigmentation0.62809223
140MP0003137_abnormal_impulse_conducting0.62230705
141MP0005310_abnormal_salivary_gland0.61247019
142MP0000465_gastrointestinal_hemorrhage0.60068457

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.00900043
2Febrile seizures (HP:0002373)4.62252387
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.38543003
4Chromsome breakage (HP:0040012)4.17844086
5Congenital stationary night blindness (HP:0007642)3.79377655
6Epileptic encephalopathy (HP:0200134)3.54434217
7Papillary thyroid carcinoma (HP:0002895)3.39091983
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.34070488
9Atonic seizures (HP:0010819)3.25245614
10Abnormal hair whorl (HP:0010721)3.05555227
11Progressive inability to walk (HP:0002505)2.93936046
12Abnormality of the renal cortex (HP:0011035)2.81466856
13Hyperventilation (HP:0002883)2.79821653
14Birth length less than 3rd percentile (HP:0003561)2.76967759
15Hemiparesis (HP:0001269)2.76566809
16Absent/shortened dynein arms (HP:0200106)2.74297341
17Dynein arm defect of respiratory motile cilia (HP:0012255)2.74297341
18Attenuation of retinal blood vessels (HP:0007843)2.68686357
19Abnormal rod and cone electroretinograms (HP:0008323)2.67086211
20Hemiplegia (HP:0002301)2.64769689
21Limb dystonia (HP:0002451)2.64129017
22Focal seizures (HP:0007359)2.63985996
23Absent speech (HP:0001344)2.63443885
24Abnormality of binocular vision (HP:0011514)2.63433760
25Diplopia (HP:0000651)2.63433760
26Protruding tongue (HP:0010808)2.58458333
27Abolished electroretinogram (ERG) (HP:0000550)2.55725542
28Broad-based gait (HP:0002136)2.55615016
29Abnormality of the labia minora (HP:0012880)2.50361804
30Male infertility (HP:0003251)2.48698151
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46478489
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.43730930
33Oligodactyly (hands) (HP:0001180)2.41751884
34Decreased central vision (HP:0007663)2.39637188
35Abnormality of midbrain morphology (HP:0002418)2.39111456
36Molar tooth sign on MRI (HP:0002419)2.39111456
37Ectopic kidney (HP:0000086)2.36329687
38Volvulus (HP:0002580)2.36037858
39Abnormal respiratory motile cilium physiology (HP:0012261)2.33539330
40Excessive salivation (HP:0003781)2.32809629
41Drooling (HP:0002307)2.32809629
42Obstructive sleep apnea (HP:0002870)2.31992966
43Renal cortical cysts (HP:0000803)2.30275189
44Abnormality of incisor morphology (HP:0011063)2.29450002
45Absence seizures (HP:0002121)2.28867368
46Nephroblastoma (Wilms tumor) (HP:0002667)2.28853828
47Meckel diverticulum (HP:0002245)2.28599021
48Inability to walk (HP:0002540)2.26643943
49Visual hallucinations (HP:0002367)2.26287960
50Abnormality of the preputium (HP:0100587)2.25681379
51Abnormality of alanine metabolism (HP:0010916)2.25457226
52Hyperalaninemia (HP:0003348)2.25457226
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25457226
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.25433868
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.25433868
56Chronic hepatic failure (HP:0100626)2.24498942
57Fair hair (HP:0002286)2.23054238
58Progressive cerebellar ataxia (HP:0002073)2.22968259
59Embryonal renal neoplasm (HP:0011794)2.21879832
60Type II lissencephaly (HP:0007260)2.21800376
61Fetal akinesia sequence (HP:0001989)2.19108131
62Action tremor (HP:0002345)2.18949274
63Abnormality of the ileum (HP:0001549)2.15667356
64Aplasia/Hypoplasia of the tibia (HP:0005772)2.15416467
65Abnormality of chromosome stability (HP:0003220)2.14031589
66Thickened helices (HP:0000391)2.13449731
67Stomach cancer (HP:0012126)2.12690671
68Nephronophthisis (HP:0000090)2.12327912
69Widely spaced teeth (HP:0000687)2.11982626
70Dialeptic seizures (HP:0011146)2.11972078
71Shawl scrotum (HP:0000049)2.11455517
72Pancreatic fibrosis (HP:0100732)2.11373323
73Patellar aplasia (HP:0006443)2.10079748
74Abnormal drinking behavior (HP:0030082)2.09725931
75Polydipsia (HP:0001959)2.09725931
76Clumsiness (HP:0002312)2.09389974
77Midline defect of the nose (HP:0004122)2.08858829
78Abnormal ciliary motility (HP:0012262)2.07666501
79Large for gestational age (HP:0001520)2.05929538
80Abnormality of the fingertips (HP:0001211)2.05532024
81Status epilepticus (HP:0002133)2.00832272
82Prostate neoplasm (HP:0100787)1.99295935
83Flat capital femoral epiphysis (HP:0003370)1.96902904
84Capillary hemangiomas (HP:0005306)1.96723656
85Stomatitis (HP:0010280)1.95933641
86Clubbing of toes (HP:0100760)1.94282324
87Polyphagia (HP:0002591)1.93591945
88Breast aplasia (HP:0100783)1.93397614
89Generalized tonic-clonic seizures (HP:0002069)1.92784398
90Aplasia/Hypoplasia of the fovea (HP:0008060)1.92461628
91Hypoplasia of the fovea (HP:0007750)1.92461628
92Abnormality of the renal medulla (HP:0100957)1.92313004
93Thyroid carcinoma (HP:0002890)1.91720598
94Duplicated collecting system (HP:0000081)1.91629018
95Myokymia (HP:0002411)1.91585239
96Gaze-evoked nystagmus (HP:0000640)1.91206634
97Pachygyria (HP:0001302)1.90399008
98Impaired vibration sensation in the lower limbs (HP:0002166)1.89603335
99Abnormality of the corticospinal tract (HP:0002492)1.88541255
100Facial hemangioma (HP:0000329)1.88106686
101Aplasia/Hypoplasia of the patella (HP:0006498)1.87326722
102Cystic liver disease (HP:0006706)1.86923916
103Abnormality of the renal collecting system (HP:0004742)1.86859979
104Abnormal respiratory epithelium morphology (HP:0012253)1.86266178
105Abnormal respiratory motile cilium morphology (HP:0005938)1.86266178
106Abnormal eating behavior (HP:0100738)1.85983736
107Lissencephaly (HP:0001339)1.85158511
108Aplasia/Hypoplasia of the sternum (HP:0006714)1.85109637
109Generalized hypopigmentation of hair (HP:0011358)1.84894950
110Abnormality of salivation (HP:0100755)1.84578485
111Nephrogenic diabetes insipidus (HP:0009806)1.84576489
112Gait imbalance (HP:0002141)1.84528071
113Postural instability (HP:0002172)1.84424724
114Aplasia/Hypoplasia of the breasts (HP:0010311)1.83974924
115Medial flaring of the eyebrow (HP:0010747)1.83358236
116Adrenal hypoplasia (HP:0000835)1.82640444
117Nonprogressive disorder (HP:0003680)1.82148753
118Papilledema (HP:0001085)1.82079520
119True hermaphroditism (HP:0010459)1.81692716
120Constricted visual fields (HP:0001133)1.81632774
121Abnormality of the fovea (HP:0000493)1.80433603
122Abnormality of chromosome segregation (HP:0002916)1.80185332
123Spastic gait (HP:0002064)1.80145489
124Urinary bladder sphincter dysfunction (HP:0002839)1.79655716
125Albinism (HP:0001022)1.78962335
126Thyroiditis (HP:0100646)1.78913018
127Embryonal neoplasm (HP:0002898)1.78678449
128Genetic anticipation (HP:0003743)1.78250826
129Narrow forehead (HP:0000341)1.74208467
130Prolonged bleeding time (HP:0003010)1.73982943
131Agitation (HP:0000713)1.73973837
132Mutism (HP:0002300)1.73967259
133Dyskinesia (HP:0100660)1.73960100
134Poor coordination (HP:0002370)1.73656689
135Cystic hygroma (HP:0000476)1.72448584
136Genital tract atresia (HP:0001827)1.72444656
137Small intestinal stenosis (HP:0012848)1.72328966
138Duodenal stenosis (HP:0100867)1.72328966
139Poor eye contact (HP:0000817)1.72177108
140Epileptiform EEG discharges (HP:0011182)1.71934800
141Absent eyebrow (HP:0002223)1.69866133
142Pancreatic cysts (HP:0001737)1.69153122
143Abnormality of the carotid arteries (HP:0005344)1.68903035
144Abnormality of macular pigmentation (HP:0008002)1.68795929
145Congenital hepatic fibrosis (HP:0002612)1.68548969
146Lip pit (HP:0100267)1.68029244
147Gastroesophageal reflux (HP:0002020)1.67991561
148Prolonged QT interval (HP:0001657)1.66924716
149Astigmatism (HP:0000483)1.66729295
150Increased corneal curvature (HP:0100692)1.66448645
151Keratoconus (HP:0000563)1.66448645
152Optic nerve hypoplasia (HP:0000609)1.65347329
153Deeply set eye (HP:0000490)1.65021507
154Cerebellar dysplasia (HP:0007033)1.64725254
155Congenital primary aphakia (HP:0007707)1.64660285
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.64599938
157Dysdiadochokinesis (HP:0002075)1.64545432
158Inappropriate behavior (HP:0000719)1.64375790
159Atelectasis (HP:0100750)1.64040773
160Furrowed tongue (HP:0000221)1.63438971
161Cupped ear (HP:0000378)1.63259596
162Specific learning disability (HP:0001328)1.62536383
163Metabolic alkalosis (HP:0200114)1.61708324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.76736873
2CASK3.47184304
3MAP2K72.86516528
4MAP3K92.79789178
5MAP3K62.67382128
6MAP3K42.64511845
7MUSK2.52663654
8EPHA42.52447007
9ADRBK22.43434248
10MAPK132.31636371
11TNIK2.23390272
12BMPR1B2.21061949
13NTRK32.13613509
14MAP3K132.04958846
15LATS22.02352804
16ERBB41.92617504
17BRAF1.92389746
18CCNB11.83679297
19KSR21.83353433
20TAOK31.82824882
21MAP4K21.80908260
22LATS11.79744485
23PLK41.74906831
24WNK31.72695088
25MARK11.72645323
26CAMKK21.68313823
27STK38L1.65250162
28SGK21.63835712
29RAF11.62280181
30PLK21.62201564
31RIPK41.59045511
32KSR11.58581650
33CDK81.58221829
34BMPR21.41282024
35PAK61.41163818
36CDK31.39726210
37TAOK11.36613976
38PAK31.36348642
39ARAF1.33322848
40NTRK21.29041613
41NEK61.25191401
42MELK1.23321870
43CHEK21.19433713
44TTK1.18666051
45WNK41.17294003
46NUAK11.16502802
47CDK91.16184994
48MAP2K41.15715490
49ZAK1.13210306
50SGK4941.13146419
51SGK2231.13146419
52PRKD31.10531998
53MAP3K121.09905949
54DMPK1.07277089
55CDC71.01426228
56STK391.00588535
57CAMKK10.99190462
58AKT30.97961194
59IRAK10.95312132
60DAPK20.92819152
61SGK30.92660623
62FES0.89848087
63ADRBK10.88895734
64TEC0.88792272
65MKNK20.88572302
66DYRK20.85871953
67PHKG10.85287099
68PHKG20.85287099
69SYK0.82179989
70PLK30.81153687
71CAMK2A0.81071625
72TRIM280.78515511
73STK380.78126823
74PRPF4B0.77950884
75INSRR0.77647308
76OBSCN0.75492688
77MST40.73256208
78TGFBR10.71443263
79PNCK0.70290076
80STK110.69758480
81MINK10.69517005
82NEK20.68895203
83TXK0.68886132
84PRKCQ0.68473662
85CAMK2B0.61743297
86CAMK1G0.61648529
87ACVR1B0.61190795
88TNK20.60303295
89SGK10.58581687
90DYRK1A0.58568988
91PLK10.56945960
92UHMK10.56940413
93CAMK1D0.55599847
94BRSK10.54857944
95IRAK20.53035985
96CSNK1G20.52425736
97KIT0.50526043
98FGR0.49673530
99SIK30.48927161
100TLK10.48270678
101CAMK40.48119925
102CDK190.48018006
103CDK50.45724294
104SRPK10.44900377
105TIE10.42791599
106WNK10.42519507
107MAP2K60.42467569
108MARK20.41574955
109MAPK100.40629847
110LYN0.40096670
111PRKACA0.39967350
112ATM0.38855505
113PRKD20.38800460
114PRKCA0.38653944
115DAPK10.38607494
116PINK10.37960318
117EIF2AK20.37849794
118VRK10.37749974
119PRKCG0.37602212
120ERBB30.36838775
121CAMK10.36834160
122STK30.36807716
123PIK3CG0.36688401
124BCR0.36642964
125EPHA30.36515250
126MAPK120.36357493
127PRKCE0.36201913
128CSNK1A1L0.35857888
129CAMK2D0.35060952
130MAPK70.34609038
131PRKCZ0.34055765
132RPS6KA30.33968454
133PIK3CA0.33324704
134PRKAA20.33010568
135PRKG10.33000656
136PRKAA10.32971016
137OXSR10.32953994
138MAP3K50.32729331
139GRK10.32603347
140PTK2B0.32292533
141PKN10.31506222
142CDK180.31156284
143STK240.30111100
144MAPKAPK50.29102677
145GRK50.28932337

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.23079166
2Glutamatergic synapse_Homo sapiens_hsa047242.12658506
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09708614
4Basal transcription factors_Homo sapiens_hsa030222.06932369
5Morphine addiction_Homo sapiens_hsa050322.00587440
6Olfactory transduction_Homo sapiens_hsa047401.99398714
7Nitrogen metabolism_Homo sapiens_hsa009101.91830708
8Long-term potentiation_Homo sapiens_hsa047201.88021946
9Circadian rhythm_Homo sapiens_hsa047101.86649527
10Circadian entrainment_Homo sapiens_hsa047131.84316962
11Serotonergic synapse_Homo sapiens_hsa047261.80748026
12Synaptic vesicle cycle_Homo sapiens_hsa047211.78122381
13Amphetamine addiction_Homo sapiens_hsa050311.77536889
14Fanconi anemia pathway_Homo sapiens_hsa034601.69022719
15Long-term depression_Homo sapiens_hsa047301.68258348
16Cell cycle_Homo sapiens_hsa041101.61602730
17Ovarian steroidogenesis_Homo sapiens_hsa049131.61251645
18GABAergic synapse_Homo sapiens_hsa047271.59789389
19GnRH signaling pathway_Homo sapiens_hsa049121.56996692
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48391022
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45165619
22Taste transduction_Homo sapiens_hsa047421.44889587
23Oocyte meiosis_Homo sapiens_hsa041141.43141718
24Butanoate metabolism_Homo sapiens_hsa006501.39569658
25Dopaminergic synapse_Homo sapiens_hsa047281.38769602
26RNA degradation_Homo sapiens_hsa030181.36140595
27Oxytocin signaling pathway_Homo sapiens_hsa049211.35757168
28Dorso-ventral axis formation_Homo sapiens_hsa043201.30055746
29Cholinergic synapse_Homo sapiens_hsa047251.28598485
30Salivary secretion_Homo sapiens_hsa049701.27730240
31Insulin secretion_Homo sapiens_hsa049111.25632131
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22219746
33Calcium signaling pathway_Homo sapiens_hsa040201.21123386
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20885535
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19809271
36cAMP signaling pathway_Homo sapiens_hsa040241.18253325
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17901423
38Pancreatic cancer_Homo sapiens_hsa052121.16437049
39Choline metabolism in cancer_Homo sapiens_hsa052311.16153286
40ErbB signaling pathway_Homo sapiens_hsa040121.15409096
41Phototransduction_Homo sapiens_hsa047441.15148474
42Colorectal cancer_Homo sapiens_hsa052101.10324713
43Tryptophan metabolism_Homo sapiens_hsa003801.10238914
44Platelet activation_Homo sapiens_hsa046111.09431463
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07749681
46Renin secretion_Homo sapiens_hsa049241.07432389
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06724844
48Cocaine addiction_Homo sapiens_hsa050301.04283564
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04164094
50MAPK signaling pathway_Homo sapiens_hsa040101.02950988
51TGF-beta signaling pathway_Homo sapiens_hsa043501.02754245
52Ether lipid metabolism_Homo sapiens_hsa005651.02415807
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02239872
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.99842090
55Axon guidance_Homo sapiens_hsa043600.99781731
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97275708
57Ras signaling pathway_Homo sapiens_hsa040140.96814921
58Asthma_Homo sapiens_hsa053100.96243938
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95355121
60Gastric acid secretion_Homo sapiens_hsa049710.95287262
61Wnt signaling pathway_Homo sapiens_hsa043100.94596087
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90581482
63Regulation of autophagy_Homo sapiens_hsa041400.89849539
64Cardiac muscle contraction_Homo sapiens_hsa042600.87759180
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87692643
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.87175326
67Endometrial cancer_Homo sapiens_hsa052130.86181185
68Prolactin signaling pathway_Homo sapiens_hsa049170.85031815
69Glioma_Homo sapiens_hsa052140.84627883
70Melanogenesis_Homo sapiens_hsa049160.84588874
71Collecting duct acid secretion_Homo sapiens_hsa049660.84106203
72Pancreatic secretion_Homo sapiens_hsa049720.82400616
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.80667086
74Gap junction_Homo sapiens_hsa045400.79812071
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79411839
76Propanoate metabolism_Homo sapiens_hsa006400.79050729
77beta-Alanine metabolism_Homo sapiens_hsa004100.77875511
78Estrogen signaling pathway_Homo sapiens_hsa049150.77044564
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76348302
80Homologous recombination_Homo sapiens_hsa034400.74939353
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74502799
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73481227
83Glycerolipid metabolism_Homo sapiens_hsa005610.71218728
84Parkinsons disease_Homo sapiens_hsa050120.71070352
85Oxidative phosphorylation_Homo sapiens_hsa001900.70510499
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69347303
87VEGF signaling pathway_Homo sapiens_hsa043700.68162679
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67109316
89FoxO signaling pathway_Homo sapiens_hsa040680.67104258
90Type I diabetes mellitus_Homo sapiens_hsa049400.66725482
91Inositol phosphate metabolism_Homo sapiens_hsa005620.64803884
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64746538
93Graft-versus-host disease_Homo sapiens_hsa053320.63195994
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62652165
95Non-small cell lung cancer_Homo sapiens_hsa052230.62090495
96Type II diabetes mellitus_Homo sapiens_hsa049300.61980532
97Melanoma_Homo sapiens_hsa052180.61069888
98Renal cell carcinoma_Homo sapiens_hsa052110.60549750
99MicroRNAs in cancer_Homo sapiens_hsa052060.60238310
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60179953
101RNA polymerase_Homo sapiens_hsa030200.60163437
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59095658
103Vitamin B6 metabolism_Homo sapiens_hsa007500.59072434
104Non-homologous end-joining_Homo sapiens_hsa034500.57871292
105Allograft rejection_Homo sapiens_hsa053300.57344022
106Chemokine signaling pathway_Homo sapiens_hsa040620.56823156
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55266277
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54465166
109Rap1 signaling pathway_Homo sapiens_hsa040150.54050755
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53584527
111Alzheimers disease_Homo sapiens_hsa050100.52483655
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.52386994
113Linoleic acid metabolism_Homo sapiens_hsa005910.52174503
114Arachidonic acid metabolism_Homo sapiens_hsa005900.52062466
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51605611
116Protein export_Homo sapiens_hsa030600.51567424
117Hematopoietic cell lineage_Homo sapiens_hsa046400.51088235
118Steroid biosynthesis_Homo sapiens_hsa001000.50848692
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50846493
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50567370
121Sphingolipid metabolism_Homo sapiens_hsa006000.50500183
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50482661
123Rheumatoid arthritis_Homo sapiens_hsa053230.50289003
124Hippo signaling pathway_Homo sapiens_hsa043900.49941949
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.48508634
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48227123
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48163505
128Histidine metabolism_Homo sapiens_hsa003400.48050324
129African trypanosomiasis_Homo sapiens_hsa051430.47996730
130Dilated cardiomyopathy_Homo sapiens_hsa054140.47741345
131ABC transporters_Homo sapiens_hsa020100.47199832
132Autoimmune thyroid disease_Homo sapiens_hsa053200.45398496
133mRNA surveillance pathway_Homo sapiens_hsa030150.45241554
134Hepatitis B_Homo sapiens_hsa051610.44151845
135Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43988869
136Primary immunodeficiency_Homo sapiens_hsa053400.43434831
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43400274
138Adherens junction_Homo sapiens_hsa045200.42857885
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42465362
140Purine metabolism_Homo sapiens_hsa002300.40285162
141Prostate cancer_Homo sapiens_hsa052150.40173609
142T cell receptor signaling pathway_Homo sapiens_hsa046600.40061781
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39404969
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.38785886
145Caffeine metabolism_Homo sapiens_hsa002320.33624567

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