GTF2A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.38725757
2nuclear pore organization (GO:0006999)5.68732868
3mitotic sister chromatid cohesion (GO:0007064)5.58338199
4pre-miRNA processing (GO:0031054)4.72931072
5paraxial mesoderm development (GO:0048339)4.55779298
6regulation of NFAT protein import into nucleus (GO:0051532)4.52989276
7regulation of posttranscriptional gene silencing (GO:0060147)4.52021089
8regulation of gene silencing by miRNA (GO:0060964)4.52021089
9regulation of gene silencing by RNA (GO:0060966)4.52021089
10mitotic chromosome condensation (GO:0007076)4.50729016
11pore complex assembly (GO:0046931)4.46021233
12DNA unwinding involved in DNA replication (GO:0006268)4.06185698
13regulation of RNA export from nucleus (GO:0046831)3.91064467
14microtubule depolymerization (GO:0007019)3.79853831
15cytoplasmic mRNA processing body assembly (GO:0033962)3.79475011
16regulation of DNA endoreduplication (GO:0032875)3.79043570
17centriole replication (GO:0007099)3.77227647
18negative regulation of fibroblast apoptotic process (GO:2000270)3.73156635
19meiotic chromosome segregation (GO:0045132)3.65006240
20negative regulation of DNA repair (GO:0045738)3.58954644
21protein localization to chromosome, centromeric region (GO:0071459)3.55724191
22protein localization to kinetochore (GO:0034501)3.52312805
23sister chromatid segregation (GO:0000819)3.51437076
24DNA ligation (GO:0006266)3.49185996
25centriole assembly (GO:0098534)3.42635191
26histone H2B ubiquitination (GO:0033523)3.39214002
27DNA methylation involved in gamete generation (GO:0043046)3.39166809
28lymphoid progenitor cell differentiation (GO:0002320)3.36776489
29regulation of centriole replication (GO:0046599)3.35727595
30positive regulation of SMAD protein import into nucleus (GO:0060391)3.35315700
31establishment of integrated proviral latency (GO:0075713)3.33789246
32regulation of nucleobase-containing compound transport (GO:0032239)3.31788242
33presynaptic membrane assembly (GO:0097105)3.26346001
34negative regulation of keratinocyte proliferation (GO:0010839)3.26252933
35regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19793534
36microtubule polymerization or depolymerization (GO:0031109)3.14848824
37mitotic sister chromatid segregation (GO:0000070)3.14798800
38regulation of histone H3-K9 methylation (GO:0051570)3.14737995
39protein localization to microtubule (GO:0035372)3.14098080
40acrosome assembly (GO:0001675)3.12743231
41kinetochore assembly (GO:0051382)3.10811019
42kinetochore organization (GO:0051383)3.07116038
43NLS-bearing protein import into nucleus (GO:0006607)3.04844980
44piRNA metabolic process (GO:0034587)3.03549955
45proteasome assembly (GO:0043248)3.02947489
46presynaptic membrane organization (GO:0097090)3.01698641
47cellular protein complex localization (GO:0034629)3.01318430
48regulation of mitotic spindle checkpoint (GO:1903504)2.99916858
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99916858
50regulation of DNA damage checkpoint (GO:2000001)2.98501798
51myoblast migration (GO:0051451)2.98238961
52peptidyl-threonine phosphorylation (GO:0018107)2.96243688
53protein K6-linked ubiquitination (GO:0085020)2.94888367
54corticosteroid receptor signaling pathway (GO:0031958)2.94300573
55CENP-A containing nucleosome assembly (GO:0034080)2.93726114
56maturation of 5.8S rRNA (GO:0000460)2.92406796
57poly(A)+ mRNA export from nucleus (GO:0016973)2.92338863
58chromosome condensation (GO:0030261)2.90698921
59peptidyl-threonine modification (GO:0018210)2.86504839
60RNA capping (GO:0036260)2.86437835
617-methylguanosine RNA capping (GO:0009452)2.86437835
62DNA topological change (GO:0006265)2.84510577
63protein neddylation (GO:0045116)2.84024294
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82737809
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82737809
66positive regulation of mitotic sister chromatid separation (GO:1901970)2.82737809
67facial nerve structural organization (GO:0021612)2.82333991
68DNA synthesis involved in DNA repair (GO:0000731)2.82181938
697-methylguanosine mRNA capping (GO:0006370)2.80554725
70sympathetic nervous system development (GO:0048485)2.78393346
71positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.76136347
72positive regulation of chromosome segregation (GO:0051984)2.75779095
73regulation of sister chromatid cohesion (GO:0007063)2.74098614
74intraciliary transport (GO:0042073)2.73688670
75chromatin remodeling at centromere (GO:0031055)2.72294956
76regulation of gene silencing (GO:0060968)2.72106139
77transcription elongation from RNA polymerase III promoter (GO:0006385)2.71233038
78termination of RNA polymerase III transcription (GO:0006386)2.71233038
79mitotic metaphase plate congression (GO:0007080)2.69686236
80regulation of chromosome segregation (GO:0051983)2.69222323
81embryonic retina morphogenesis in camera-type eye (GO:0060059)2.68532077
82negative regulation of gene silencing (GO:0060969)2.68147545
83protein complex localization (GO:0031503)2.67520576
84superoxide anion generation (GO:0042554)2.66986065
85anterior/posterior axis specification, embryo (GO:0008595)2.66152256
86establishment of nucleus localization (GO:0040023)2.64160288
87positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.62662149
88positive regulation of cell cycle G2/M phase transition (GO:1902751)2.62662149
89histone H3-K36 demethylation (GO:0070544)2.60391047
90negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.60068203
91regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59875290
92regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.59875290
93mannosylation (GO:0097502)2.59216187
94regulation of sister chromatid segregation (GO:0033045)2.58691581
95regulation of mitotic sister chromatid separation (GO:0010965)2.58691581
96regulation of mitotic sister chromatid segregation (GO:0033047)2.58691581
97cranial nerve morphogenesis (GO:0021602)2.58638348
98regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.58099910
99atrial cardiac muscle cell action potential (GO:0086014)2.56281306
100protein localization to chromosome (GO:0034502)2.55925784
101cytoskeleton-dependent cytokinesis (GO:0061640)2.54135225
102phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.54074585
103regulation of spindle organization (GO:0090224)2.53727427
104generation of neurons (GO:0048699)2.52913913
105female gonad development (GO:0008585)2.52648327
106regulation of helicase activity (GO:0051095)2.52612056
107dendritic cell chemotaxis (GO:0002407)2.52372104
108protein K11-linked deubiquitination (GO:0035871)2.51445510
109attachment of spindle microtubules to kinetochore (GO:0008608)2.51419174
110spindle checkpoint (GO:0031577)2.50502257
111regulation of dendritic cell antigen processing and presentation (GO:0002604)2.49989679
112embryonic camera-type eye morphogenesis (GO:0048596)2.49956734
113negative regulation of myoblast differentiation (GO:0045662)2.49357573
114metaphase plate congression (GO:0051310)2.48688319
115monoubiquitinated protein deubiquitination (GO:0035520)2.47983004
116negative regulation of DNA-dependent DNA replication (GO:2000104)2.47692228
117mitotic G2/M transition checkpoint (GO:0044818)2.47094340
118cellular response to gamma radiation (GO:0071480)2.46950096
119positive regulation of catenin import into nucleus (GO:0035413)2.46329304
120mitotic cytokinesis (GO:0000281)2.46123604
121negative regulation of execution phase of apoptosis (GO:1900118)2.45348508
122notochord development (GO:0030903)2.44787094
123regulation of rhodopsin mediated signaling pathway (GO:0022400)2.44293145
124DNA replication checkpoint (GO:0000076)2.43575854
125gastrulation with mouth forming second (GO:0001702)2.43167187
126establishment of chromosome localization (GO:0051303)2.42934038
127pyrimidine dimer repair (GO:0006290)2.42833660
128DNA packaging (GO:0006323)2.42680515
129regulation of RIG-I signaling pathway (GO:0039535)2.42643901
130negative regulation of histone methylation (GO:0031061)2.42101454
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.41950301
132negative regulation of dendrite morphogenesis (GO:0050774)2.41705042
133regulation of centrosome cycle (GO:0046605)2.40602927
134negative regulation of chromosome segregation (GO:0051985)2.40372840
135GMP metabolic process (GO:0046037)2.39596354
136single strand break repair (GO:0000012)2.39496844
137negative regulation of mitotic sister chromatid separation (GO:2000816)2.39168214
138negative regulation of sister chromatid segregation (GO:0033046)2.39168214
139negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.39168214
140negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.39168214
141negative regulation of mitotic sister chromatid segregation (GO:0033048)2.39168214
142glucocorticoid receptor signaling pathway (GO:0042921)2.37827581
143protein localization to cytoskeleton (GO:0044380)2.37734320
144nuclear envelope disassembly (GO:0051081)2.36967382
145membrane disassembly (GO:0030397)2.36967382
146regulation of double-strand break repair via homologous recombination (GO:0010569)2.36738723
147apical protein localization (GO:0045176)2.36055421
148nucleus localization (GO:0051647)2.35881953
149hippo signaling (GO:0035329)2.35602349
150rhodopsin mediated signaling pathway (GO:0016056)2.35043500
151protein localization to cilium (GO:0061512)2.34299807
152sister chromatid cohesion (GO:0007062)2.33816114
153positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.30273973
154mesonephros development (GO:0001823)2.29922103
155negative regulation of signal transduction by p53 class mediator (GO:1901797)2.28770849
156myeloid dendritic cell activation (GO:0001773)2.28459682
157male meiosis I (GO:0007141)2.28424131
158positive regulation of mitochondrial fission (GO:0090141)2.28229546
159replication fork processing (GO:0031297)2.28102749
160regulation of transcription from RNA polymerase I promoter (GO:0006356)2.28012895
161regulation of activation of Janus kinase activity (GO:0010533)2.27238564
162mesenchymal cell differentiation involved in renal system development (GO:2001012)2.25950867
163mesenchymal cell differentiation involved in kidney development (GO:0072161)2.25950867
164maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.25676872
165nucleotide transmembrane transport (GO:1901679)2.24749033
166DNA double-strand break processing (GO:0000729)2.24104911
167histone exchange (GO:0043486)2.22970213
168limb bud formation (GO:0060174)2.19676401
169regulation of meiosis I (GO:0060631)2.19202800
170intra-S DNA damage checkpoint (GO:0031573)2.18528235
171regulation of keratinocyte proliferation (GO:0010837)2.17709446
172neural tube formation (GO:0001841)2.17587328
173DNA replication-independent nucleosome organization (GO:0034724)2.16406973
174DNA replication-independent nucleosome assembly (GO:0006336)2.16406973
175regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.16143044
176cranial nerve structural organization (GO:0021604)2.15963356
177negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.15664970
178regulation of female gonad development (GO:2000194)2.15374890
179interkinetic nuclear migration (GO:0022027)2.14008928
180DNA catabolic process, exonucleolytic (GO:0000738)2.13775362
181meiotic cell cycle (GO:0051321)2.12129099
182reciprocal DNA recombination (GO:0035825)2.11878059
183reciprocal meiotic recombination (GO:0007131)2.11878059
184positive regulation of meiosis (GO:0045836)2.09114861
185postsynaptic membrane organization (GO:0001941)2.08724215
186dendritic cell migration (GO:0036336)2.08657858
187respiratory chain complex IV assembly (GO:0008535)2.08608835
188regulation of non-canonical Wnt signaling pathway (GO:2000050)2.08464075
189protein localization to microtubule cytoskeleton (GO:0072698)2.07419608
190male meiosis (GO:0007140)2.06695677
191microtubule anchoring (GO:0034453)2.06290752
192regulation of timing of cell differentiation (GO:0048505)2.05140806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.81903287
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.79020334
3AR_21909140_ChIP-Seq_LNCAP_Human3.08337358
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.01152755
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.88716175
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.79163548
7GBX2_23144817_ChIP-Seq_PC3_Human2.68285083
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54523907
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53475960
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51281479
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50769783
12TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.47735557
13TAF15_26573619_Chip-Seq_HEK293_Human2.42380156
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.32398607
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31046665
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29642887
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.27859187
18IGF1R_20145208_ChIP-Seq_DFB_Human2.25392878
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.22980988
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22124886
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.11917471
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10633580
23E2F7_22180533_ChIP-Seq_HELA_Human2.08769655
24SUZ12_27294783_Chip-Seq_NPCs_Mouse2.07837279
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.07448193
26GATA1_22025678_ChIP-Seq_K562_Human2.03879742
27RNF2_27304074_Chip-Seq_NSC_Mouse2.01682198
28FUS_26573619_Chip-Seq_HEK293_Human2.00460941
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.99938313
30EWS_26573619_Chip-Seq_HEK293_Human1.89083105
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.84988243
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.80836445
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.78503884
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.77880395
35P300_19829295_ChIP-Seq_ESCs_Human1.77507493
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76238954
37EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.75985408
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75525957
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.70301119
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.67923343
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66636655
42E2F1_18555785_Chip-Seq_ESCs_Mouse1.65802683
43STAT3_18555785_Chip-Seq_ESCs_Mouse1.64270831
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.62428613
45EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.62106137
46P53_22387025_ChIP-Seq_ESCs_Mouse1.60121068
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60030372
48VDR_22108803_ChIP-Seq_LS180_Human1.56677582
49CMYC_18555785_Chip-Seq_ESCs_Mouse1.54199805
50NMYC_18555785_Chip-Seq_ESCs_Mouse1.53397621
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53066637
52RUNX1_27457419_Chip-Seq_LIVER_Mouse1.53039958
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51562177
54* ER_23166858_ChIP-Seq_MCF-7_Human1.51514255
55* E2F1_21310950_ChIP-Seq_MCF-7_Human1.49920355
56P300_18555785_Chip-Seq_ESCs_Mouse1.49778375
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49606838
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.48755962
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.48755962
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.48755962
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46850517
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46506596
63SOX2_18555785_Chip-Seq_ESCs_Mouse1.45512382
64* ELK1_19687146_ChIP-ChIP_HELA_Human1.45486697
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44911526
66OCT4_18555785_Chip-Seq_ESCs_Mouse1.41369066
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40699286
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39363532
69IRF1_19129219_ChIP-ChIP_H3396_Human1.39345046
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.38632638
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38163647
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37455504
73EZH2_22144423_ChIP-Seq_EOC_Human1.34286678
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33984017
75ZFX_18555785_Chip-Seq_ESCs_Mouse1.32730704
76KLF4_18555785_Chip-Seq_ESCs_Mouse1.30264327
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27322791
78LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25752692
79* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25246345
80PU1_27457419_Chip-Seq_LIVER_Mouse1.24688223
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24593029
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24133921
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24107406
84* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23867376
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.23475215
86* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23135619
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.22399766
88* TAL1_26923725_Chip-Seq_HPCs_Mouse1.22147280
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22028434
90* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21794614
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21396002
92ESRRB_18555785_Chip-Seq_ESCs_Mouse1.20770097
93CTCF_18555785_Chip-Seq_ESCs_Mouse1.20589423
94SOX9_26525672_Chip-Seq_HEART_Mouse1.20413824
95GABP_17652178_ChIP-ChIP_JURKAT_Human1.20221772
96* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.19261272
97SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19179283
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18356578
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18091870
100SMAD4_21799915_ChIP-Seq_A2780_Human1.17636127
101DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16490925
102* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16195537
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14497161
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14139044
105AR_21572438_ChIP-Seq_LNCaP_Human1.14027830
106* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13893687
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13739619
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13402850
109BP1_19119308_ChIP-ChIP_Hs578T_Human1.13393492
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12966464
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12551556
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12079165
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11327111
114* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11243131
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10825879
116GF1B_26923725_Chip-Seq_HPCs_Mouse1.10708530
117* TP63_19390658_ChIP-ChIP_HaCaT_Human1.09630859
118TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09145422
119GATA1_26923725_Chip-Seq_HPCs_Mouse1.08613173
120SRF_21415370_ChIP-Seq_HL-1_Mouse1.08476022
121* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08316194
122ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07246373
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07188891
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06822356
125STAT3_23295773_ChIP-Seq_U87_Human1.06822331
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05849166
127CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05614850
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05006838
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05006838
130MYC_18940864_ChIP-ChIP_HL60_Human1.04510820
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03789257
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03789257
133IRF8_21731497_ChIP-ChIP_J774_Mouse1.03509673
134EP300_21415370_ChIP-Seq_HL-1_Mouse1.03461257
135TCF4_18268006_ChIP-ChIP_LS174T_Human1.03044333
136NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02375026
137JUN_21703547_ChIP-Seq_K562_Human1.01930588
138WT1_19549856_ChIP-ChIP_CCG9911_Human1.01848295
139PIAS1_25552417_ChIP-Seq_VCAP_Human1.01628688
140POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01056406
141SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.00928022
142KDM2B_26808549_Chip-Seq_REH_Human1.00697650
143CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00495705
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00450914
145OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00361001
146SALL1_21062744_ChIP-ChIP_HESCs_Human1.00167258
147WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97998640
148NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97772430
149SOX2_16153702_ChIP-ChIP_HESCs_Human0.97767954
150SMAD3_21741376_ChIP-Seq_EPCs_Human0.97567519
151RUNX2_22187159_ChIP-Seq_PCA_Human0.97453130
152CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97395470
153CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96978276
154* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95476250
155LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95404626
156KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94451093
157BRD4_25478319_ChIP-Seq_HGPS_Human0.94396116
158PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92589927
159ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91995743
160STAT3_18555785_ChIP-Seq_MESCs_Mouse0.91517433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry3.80753728
2MP0001188_hyperpigmentation3.70409364
3MP0000566_synostosis3.35869900
4MP0003136_yellow_coat_color3.27428239
5MP0000569_abnormal_digit_pigmentation3.12189393
6MP0010352_gastrointestinal_tract_polyps3.11479723
7MP0006292_abnormal_olfactory_placode3.09943522
8MP0000015_abnormal_ear_pigmentation2.71653136
9MP0004957_abnormal_blastocyst_morpholog2.62423100
10MP0002163_abnormal_gland_morphology2.52073833
11MP0003705_abnormal_hypodermis_morpholog2.46595869
12MP0002876_abnormal_thyroid_physiology2.39459901
13MP0001986_abnormal_taste_sensitivity2.38018773
14MP0008877_abnormal_DNA_methylation2.37136749
15MP0000372_irregular_coat_pigmentation2.32921479
16MP0005409_darkened_coat_color2.19751491
17MP0010234_abnormal_vibrissa_follicle2.11797299
18MP0008058_abnormal_DNA_repair2.07774946
19MP0002277_abnormal_respiratory_mucosa2.07151611
20MP0008057_abnormal_DNA_replication2.05864663
21MP0003880_abnormal_central_pattern2.03831357
22MP0005171_absent_coat_pigmentation2.00473986
23MP0003111_abnormal_nucleus_morphology1.94341079
24MP0001346_abnormal_lacrimal_gland1.87471104
25MP0009672_abnormal_birth_weight1.87288270
26MP0010678_abnormal_skin_adnexa1.85601148
27MP0004381_abnormal_hair_follicle1.80659723
28MP0002102_abnormal_ear_morphology1.77508375
29MP0002009_preneoplasia1.75296543
30MP0002095_abnormal_skin_pigmentation1.74749902
31MP0000428_abnormal_craniofacial_morphol1.71694925
32MP0008007_abnormal_cellular_replicative1.69422598
33MP0003718_maternal_effect1.67929479
34MP0008789_abnormal_olfactory_epithelium1.66896301
35MP0001835_abnormal_antigen_presentation1.66641282
36MP0005408_hypopigmentation1.65783964
37MP0005174_abnormal_tail_pigmentation1.65644353
38MP0002697_abnormal_eye_size1.64830603
39MP0000350_abnormal_cell_proliferation1.64729781
40MP0005379_endocrine/exocrine_gland_phen1.63946624
41MP0002084_abnormal_developmental_patter1.62984330
42MP0001730_embryonic_growth_arrest1.61021505
43MP0010307_abnormal_tumor_latency1.60695494
44MP0000383_abnormal_hair_follicle1.56472854
45MP0002938_white_spotting1.54793689
46MP0001915_intracranial_hemorrhage1.54339520
47MP0001672_abnormal_embryogenesis/_devel1.54213780
48MP0005380_embryogenesis_phenotype1.54213780
49MP0005645_abnormal_hypothalamus_physiol1.52576346
50MP0003567_abnormal_fetal_cardiomyocyte1.52141589
51MP0003984_embryonic_growth_retardation1.51680640
52MP0002088_abnormal_embryonic_growth/wei1.51529435
53MP0005076_abnormal_cell_differentiation1.51321493
54MP0009703_decreased_birth_body1.51285012
55MP0002877_abnormal_melanocyte_morpholog1.49621746
56MP0003787_abnormal_imprinting1.49018051
57MP0010094_abnormal_chromosome_stability1.48707879
58MP0002085_abnormal_embryonic_tissue1.47229317
59MP0001299_abnormal_eye_distance/1.47147682
60MP0002638_abnormal_pupillary_reflex1.46724925
61MP0004233_abnormal_muscle_weight1.45455916
62MP0004185_abnormal_adipocyte_glucose1.44690334
63MP0003566_abnormal_cell_adhesion1.44440396
64MP0002177_abnormal_outer_ear1.43748710
65MP0003315_abnormal_perineum_morphology1.41347508
66MP0008260_abnormal_autophagy1.41161353
67MP0009697_abnormal_copulation1.40547821
68MP0002160_abnormal_reproductive_system1.38556544
69MP0005075_abnormal_melanosome_morpholog1.37564690
70MP0001697_abnormal_embryo_size1.37070703
71MP0002086_abnormal_extraembryonic_tissu1.35705086
72MP0001984_abnormal_olfaction1.31065673
73MP0003941_abnormal_skin_development1.27783206
74MP0004197_abnormal_fetal_growth/weight/1.25416100
75MP0003091_abnormal_cell_migration1.24998343
76MP0006054_spinal_hemorrhage1.24667873
77MP0002148_abnormal_hypersensitivity_rea1.24186265
78MP0003935_abnormal_craniofacial_develop1.24124555
79MP0004147_increased_porphyrin_level1.22483963
80MP0002210_abnormal_sex_determination1.21327294
81MP0003861_abnormal_nervous_system1.20559858
82MP0003937_abnormal_limbs/digits/tail_de1.20318841
83MP0004782_abnormal_surfactant_physiolog1.19035607
84MP0002132_abnormal_respiratory_system1.16912116
85MP0002751_abnormal_autonomic_nervous1.14850412
86MP0000432_abnormal_head_morphology1.14317645
87MP0001529_abnormal_vocalization1.13854774
88MP0001293_anophthalmia1.13361448
89MP0002092_abnormal_eye_morphology1.12986949
90MP0005499_abnormal_olfactory_system1.12984879
91MP0005394_taste/olfaction_phenotype1.12984879
92MP0003693_abnormal_embryo_hatching1.12892645
93MP0003786_premature_aging1.12652388
94MP0005671_abnormal_response_to1.11266429
95MP0009250_abnormal_appendicular_skeleto1.10859286
96MP0005646_abnormal_pituitary_gland1.10647750
97MP0001905_abnormal_dopamine_level1.08918549
98MP0000026_abnormal_inner_ear1.08650060
99MP0000049_abnormal_middle_ear1.07698999
100MP0008995_early_reproductive_senescence1.07112568
101MP0001119_abnormal_female_reproductive1.06324455
102MP0004270_analgesia1.06067706
103MP0003221_abnormal_cardiomyocyte_apopto1.05026162
104MP0005187_abnormal_penis_morphology1.04333253
105MP0000778_abnormal_nervous_system1.04321974
106MP0001963_abnormal_hearing_physiology1.03763466
107MP0003077_abnormal_cell_cycle1.03712127
108MP0004742_abnormal_vestibular_system1.03594153
109MP0001485_abnormal_pinna_reflex1.03577616
110MP0003938_abnormal_ear_development1.03274379
111MP0002080_prenatal_lethality1.02878182
112MP0005310_abnormal_salivary_gland1.02371919
113MP0002735_abnormal_chemical_nociception1.00612131
114MP0004808_abnormal_hematopoietic_stem0.98975341
115MP0004272_abnormal_basement_membrane0.98580649
116MP0002081_perinatal_lethality0.97899628
117MP0003121_genomic_imprinting0.97444631
118MP0002796_impaired_skin_barrier0.96829826
119MP0009053_abnormal_anal_canal0.96334713
120MP0002925_abnormal_cardiovascular_devel0.95775033
121MP0009379_abnormal_foot_pigmentation0.93613115
122MP0003183_abnormal_peptide_metabolism0.93471813
123MP0003453_abnormal_keratinocyte_physiol0.92992399
124MP0000537_abnormal_urethra_morphology0.92305682
125MP0006276_abnormal_autonomic_nervous0.92150592
126MP0000681_abnormal_thyroid_gland0.90141208
127MP0002249_abnormal_larynx_morphology0.89460262
128MP0005451_abnormal_body_composition0.86537567
129MP0005389_reproductive_system_phenotype0.85547198
130MP0001919_abnormal_reproductive_system0.85238922
131MP0000534_abnormal_ureter_morphology0.84652386
132MP0003690_abnormal_glial_cell0.84447490
133MP0000427_abnormal_hair_cycle0.84355910
134MP0003119_abnormal_digestive_system0.84181848
135MP0002233_abnormal_nose_morphology0.84108010
136MP0000647_abnormal_sebaceous_gland0.83612732
137MP0001929_abnormal_gametogenesis0.83524292
138MP0001177_atelectasis0.83072845
139MP0000631_abnormal_neuroendocrine_gland0.82873783
140MP0005197_abnormal_uvea_morphology0.82772772
141MP0004885_abnormal_endolymph0.82481785
142MP0005621_abnormal_cell_physiology0.81918025
143MP0002396_abnormal_hematopoietic_system0.81418288
144MP0000653_abnormal_sex_gland0.81313385
145MP0003123_paternal_imprinting0.81058233
146MP0009785_altered_susceptibility_to0.81051299
147MP0000627_abnormal_mammary_gland0.79768283
148MP0000955_abnormal_spinal_cord0.78625653
149MP0008932_abnormal_embryonic_tissue0.78095986
150MP0005367_renal/urinary_system_phenotyp0.77344039
151MP0000516_abnormal_urinary_system0.77344039
152MP0000613_abnormal_salivary_gland0.77114432
153MP0002184_abnormal_innervation0.76552851
154MP0001145_abnormal_male_reproductive0.76138722
155MP0002734_abnormal_mechanical_nocicepti0.75761449
156MP0004811_abnormal_neuron_physiology0.75272947
157MP0001968_abnormal_touch/_nociception0.73739581
158MP0005248_abnormal_Harderian_gland0.73609195
159MP0003763_abnormal_thymus_physiology0.72991746
160MP0000685_abnormal_immune_system0.72735297
161MP0003755_abnormal_palate_morphology0.72213705
162MP0003385_abnormal_body_wall0.72124751
163MP0003943_abnormal_hepatobiliary_system0.71591484
164MP0003942_abnormal_urinary_system0.71552432
165MP0001186_pigmentation_phenotype0.70425537
166MP0002111_abnormal_tail_morphology0.69757095
167MP0005384_cellular_phenotype0.69728818
168MP0002752_abnormal_somatic_nervous0.69454295
169MP0009333_abnormal_splenocyte_physiolog0.69036723
170MP0002152_abnormal_brain_morphology0.68802796
171MP0005275_abnormal_skin_tensile0.67730110
172MP0001286_abnormal_eye_development0.66927959
173MP0003300_gastrointestinal_ulcer0.65298155

Predicted human phenotypes

RankGene SetZ-score
1Vertebral arch anomaly (HP:0008438)4.07859523
2Chromsome breakage (HP:0040012)3.96864341
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.90613011
4Cortical dysplasia (HP:0002539)3.75843623
5Volvulus (HP:0002580)3.69928128
6True hermaphroditism (HP:0010459)3.48157585
7Hypothermia (HP:0002045)3.46506922
8Pancreatic fibrosis (HP:0100732)3.08883579
9Prostate neoplasm (HP:0100787)3.07940059
10Abnormal hair whorl (HP:0010721)3.00788292
11Curly hair (HP:0002212)2.93620227
12Insidious onset (HP:0003587)2.91728815
13Termporal pattern (HP:0011008)2.91728815
14Abnormality of incisor morphology (HP:0011063)2.91327237
15White forelock (HP:0002211)2.91116597
16Deep philtrum (HP:0002002)2.89828918
17Type I transferrin isoform profile (HP:0003642)2.86331399
18Patchy hypopigmentation of hair (HP:0011365)2.84117381
19Medulloblastoma (HP:0002885)2.82427644
20Overlapping toe (HP:0001845)2.81931237
21Missing ribs (HP:0000921)2.79940181
22Abnormal lung lobation (HP:0002101)2.74366894
23Adrenal hypoplasia (HP:0000835)2.69614905
24Ankyloglossia (HP:0010296)2.68682292
25Papillary thyroid carcinoma (HP:0002895)2.65815025
26Medial flaring of the eyebrow (HP:0010747)2.63595610
27Lip pit (HP:0100267)2.62355403
28Ectopic kidney (HP:0000086)2.61194543
29Pancreatic cysts (HP:0001737)2.58190058
30Dysmetric saccades (HP:0000641)2.57973827
31Rhabdomyosarcoma (HP:0002859)2.49885303
32Meckel diverticulum (HP:0002245)2.48488010
33Increased nuchal translucency (HP:0010880)2.48406139
34Transitional cell carcinoma of the bladder (HP:0006740)2.48226704
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.48082139
36Type 2 muscle fiber atrophy (HP:0003554)2.46825948
37Nonprogressive disorder (HP:0003680)2.46519267
38Nephrogenic diabetes insipidus (HP:0009806)2.43538356
39Abnormality of the preputium (HP:0100587)2.42622758
40Supernumerary spleens (HP:0009799)2.42336990
41Congenital primary aphakia (HP:0007707)2.40309339
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.39345469
43Gastrointestinal carcinoma (HP:0002672)2.37844635
44Malignant gastrointestinal tract tumors (HP:0006749)2.37844635
45Preaxial hand polydactyly (HP:0001177)2.37259567
46Bladder neoplasm (HP:0009725)2.37210415
47Bladder carcinoma (HP:0002862)2.37210415
48Low anterior hairline (HP:0000294)2.36835624
49Leiomyosarcoma (HP:0100243)2.36541450
50Uterine leiomyosarcoma (HP:0002891)2.36541450
51Gait imbalance (HP:0002141)2.36299675
52Cystic hygroma (HP:0000476)2.34595348
53Poor coordination (HP:0002370)2.31554795
54Abnormality of chromosome stability (HP:0003220)2.31469979
55Molar tooth sign on MRI (HP:0002419)2.30954064
56Abnormality of midbrain morphology (HP:0002418)2.30954064
57Short tibia (HP:0005736)2.30701237
58Abnormality of the ileum (HP:0001549)2.29731280
59Abnormality of the parietal bone (HP:0002696)2.27528376
60Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.19241921
61Abnormality of chromosome segregation (HP:0002916)2.17793690
62Clubbing of toes (HP:0100760)2.17218129
63Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.15128494
64Nephroblastoma (Wilms tumor) (HP:0002667)2.15062760
65Thyroid carcinoma (HP:0002890)2.13405694
66Nephronophthisis (HP:0000090)2.12747217
67Spinal cord lesions (HP:0100561)2.10210505
68Syringomyelia (HP:0003396)2.10210505
69Genital tract atresia (HP:0001827)2.09554545
70Overgrowth (HP:0001548)2.09038922
71Capillary hemangiomas (HP:0005306)2.07712963
72Large earlobe (HP:0009748)2.06986674
73Abnormality of secondary sexual hair (HP:0009888)2.06796135
74Abnormality of the axillary hair (HP:0100134)2.06796135
75Male pseudohermaphroditism (HP:0000037)2.04915066
76Abnormality of the columella (HP:0009929)2.04800807
77Birth length less than 3rd percentile (HP:0003561)2.04610479
78Median cleft lip (HP:0000161)2.04546191
79Aplasia/Hypoplasia of the tongue (HP:0010295)2.04253770
80Abnormality of the phalanges of the hallux (HP:0010057)2.03759113
81Vaginal atresia (HP:0000148)2.03373028
82Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02730333
83Attenuation of retinal blood vessels (HP:0007843)2.00667842
84Abnormality of oral frenula (HP:0000190)2.00588888
85Aganglionic megacolon (HP:0002251)2.00113975
86Embryonal renal neoplasm (HP:0011794)1.99093438
87Menstrual irregularities (HP:0000858)1.98878480
88Neoplasm of the thyroid gland (HP:0100031)1.98417674
89Azoospermia (HP:0000027)1.98312345
90Obsessive-compulsive behavior (HP:0000722)1.97583298
91Neoplasm of striated muscle (HP:0009728)1.96451139
92Abnormal ciliary motility (HP:0012262)1.95221762
93Heterotopia (HP:0002282)1.94850146
94Impaired vibration sensation in the lower limbs (HP:0002166)1.94742798
95Retrobulbar optic neuritis (HP:0100654)1.94585436
96Optic neuritis (HP:0100653)1.94585436
97Parakeratosis (HP:0001036)1.93597342
98Abnormality of the prostate (HP:0008775)1.93115247
99Biliary tract neoplasm (HP:0100574)1.91890988
100Drooling (HP:0002307)1.91870329
101Patellar aplasia (HP:0006443)1.91583206
102Pelvic girdle muscle weakness (HP:0003749)1.91138365
103Subaortic stenosis (HP:0001682)1.91071775
104Abnormality of the left ventricular outflow tract (HP:0011103)1.91071775
105Muscle fiber atrophy (HP:0100295)1.90328521
106Postaxial foot polydactyly (HP:0001830)1.89817781
107Duodenal stenosis (HP:0100867)1.89591652
108Small intestinal stenosis (HP:0012848)1.89591652
109Shoulder girdle muscle weakness (HP:0003547)1.89014126
110Macroorchidism (HP:0000053)1.88746951
111Colon cancer (HP:0003003)1.88648781
112Scanning speech (HP:0002168)1.88593607
113Pulmonic stenosis (HP:0001642)1.87622659
114Abnormal respiratory motile cilium physiology (HP:0012261)1.86986212
115Thyroid-stimulating hormone excess (HP:0002925)1.86755967
116Truncal obesity (HP:0001956)1.86180837
117Abnormal spermatogenesis (HP:0008669)1.85843233
118Recurrent pneumonia (HP:0006532)1.84359005
119Anencephaly (HP:0002323)1.83648275
120Abnormality of the renal medulla (HP:0100957)1.83450204
121Absent eyebrow (HP:0002223)1.83285570
122Chorioretinal coloboma (HP:0000567)1.83268726
123Acute lymphatic leukemia (HP:0006721)1.83175898
124Uterine neoplasm (HP:0010784)1.82405058
125Abnormality of the nasal septum (HP:0000419)1.82208229
126Aplasia/Hypoplasia of the patella (HP:0006498)1.81806884
127Cubitus valgus (HP:0002967)1.77714834
128Abnormality of the septum pellucidum (HP:0007375)1.77571085
129Deep palmar crease (HP:0006191)1.77553343
130Relative macrocephaly (HP:0004482)1.76821165
131Abnormality of the distal phalanx of the thumb (HP:0009617)1.75718997
132Progressive external ophthalmoplegia (HP:0000590)1.75687739
133Severe visual impairment (HP:0001141)1.75204656
134Scotoma (HP:0000575)1.75161408
135Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74968907
136Hepatoblastoma (HP:0002884)1.74425248
137Abnormality of the lacrimal duct (HP:0011481)1.73976666
138Excessive salivation (HP:0003781)1.73959827
139Acute myeloid leukemia (HP:0004808)1.73038040
140Neoplasm of the small intestine (HP:0100833)1.72610851
141Morphological abnormality of the inner ear (HP:0011390)1.72542568
142Hypoplasia of the maxilla (HP:0000327)1.72510484
143Septo-optic dysplasia (HP:0100842)1.72449666
144Synophrys (HP:0000664)1.72239335
145Tubulointerstitial nephritis (HP:0001970)1.72233237
146Asymmetry of the thorax (HP:0001555)1.71943302
147Nasolacrimal duct obstruction (HP:0000579)1.71147423
148Weak cry (HP:0001612)1.70432348
149Hypoplasia of the fovea (HP:0007750)1.69904634
150Aplasia/Hypoplasia of the fovea (HP:0008060)1.69904634
151Agnosia (HP:0010524)1.69884457
152Tetraparesis (HP:0002273)1.69713770
153Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.69608571
154Inappropriate behavior (HP:0000719)1.69536828
155Triangular face (HP:0000325)1.69203130
156Abnormality of the labia minora (HP:0012880)1.68122708
157Occipital encephalocele (HP:0002085)1.67378320
158Action tremor (HP:0002345)1.67289702
159Abnormal respiratory epithelium morphology (HP:0012253)1.67110972
160Abnormal respiratory motile cilium morphology (HP:0005938)1.67110972
161Reduced antithrombin III activity (HP:0001976)1.66988349
162Absent septum pellucidum (HP:0001331)1.66096436
163Abnormal rod and cone electroretinograms (HP:0008323)1.65785433
164Thick eyebrow (HP:0000574)1.65079795
165Abnormality of the musculature of the pelvis (HP:0001469)1.64887426
166Abnormality of the hip-girdle musculature (HP:0001445)1.64887426
167Anomalous pulmonary venous return (HP:0010772)1.64510302
168Low posterior hairline (HP:0002162)1.63938250
169Optic nerve hypoplasia (HP:0000609)1.63701476
170Abnormality of the incisor (HP:0000676)1.63320117
171Abnormality of male internal genitalia (HP:0000022)1.63088781
172Abnormality of cochlea (HP:0000375)1.62784881
173Neonatal hypoglycemia (HP:0001998)1.60889035
174Cafe-au-lait spot (HP:0000957)1.60531457
175Thickened helices (HP:0000391)1.59696359
176Deviation of the thumb (HP:0009603)1.59669857
177Disinhibition (HP:0000734)1.59662206
178Short palm (HP:0004279)1.58489349
179Arnold-Chiari malformation (HP:0002308)1.58308844
180Long eyelashes (HP:0000527)1.57644666
181Resting tremor (HP:0002322)1.56497006
182Narrow palate (HP:0000189)1.55034892
183Gonadotropin excess (HP:0000837)1.54459128
184Subacute progressive viral hepatitis (HP:0006572)1.53944125
185Arterial tortuosity (HP:0005116)1.52946220
186Omphalocele (HP:0001539)1.52686099
187Hypoplastic labia majora (HP:0000059)1.51964413
188Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.51904270
189Short 4th metacarpal (HP:0010044)1.51904270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.92874845
2PNCK4.48724684
3MAP3K93.36166406
4SRPK13.21712399
5LATS23.19227259
6MKNK12.96203330
7MKNK22.85474644
8MUSK2.71389006
9TSSK62.39677334
10BRD42.36557106
11KSR12.30523918
12CAMK1G2.23408039
13TNIK2.21593868
14MAP3K102.18978445
15MAP3K142.16859625
16AKT32.04862837
17IRAK42.02518570
18STK38L1.99400967
19PLK41.93782539
20CDK121.89365069
21BMPR21.89151406
22BMPR1B1.80289338
23MAPK131.78468734
24BCR1.68432271
25NUAK11.68125155
26ERBB31.65712642
27VRK11.64934180
28PDGFRA1.60807372
29SIK31.60230133
30ZAK1.57046525
31TTK1.54342258
32EIF2AK21.52992695
33CDK81.42520452
34SGK21.42450480
35STK161.40820834
36MAP3K21.37811557
37YES11.36977815
38NTRK11.34269701
39NEK61.34223367
40KSR21.33266451
41TLK11.31713441
42PRPF4B1.30686403
43BRSK21.30376096
44CDC71.28817361
45STK241.28204377
46CDK31.27942383
47MAP3K41.27611864
48IRAK31.26849607
49CAMK1D1.26267149
50MAP2K71.24104498
51PLK21.23206943
52NTRK21.18919315
53NTRK31.17326848
54TXK1.16626292
55WNK11.15225849
56NLK1.13092717
57DYRK31.12090153
58EIF2AK31.09673017
59CDK61.06710706
60ADRBK21.05842703
61FGFR31.05291818
62PDGFRB1.05211229
63CLK11.04941563
64NEK11.02303688
65TEC1.01453680
66LATS11.00753650
67KIT0.99113602
68SGK2230.97509409
69SGK4940.97509409
70PLK30.94860985
71PBK0.94502161
72DYRK20.94453008
73PASK0.93449875
74SCYL20.91170432
75FGR0.90144567
76MARK10.89881422
77PKN10.87478404
78MST40.86932071
79IKBKB0.85097648
80IKBKE0.84133626
81BUB10.81272525
82TYRO30.80191657
83CHUK0.77060198
84ERBB40.75794441
85IRAK20.74333669
86ALK0.74034881
87IRAK10.71976148
88OXSR10.71923120
89MAP3K120.71884911
90GRK10.71264366
91CHEK20.70196105
92STK30.68887370
93ACVR1B0.68654596
94MAP3K60.67258613
95STK390.66681814
96RPS6KA50.65847753
97MELK0.64643114
98CSNK1G10.64054877
99BRAF0.62585509
100EIF2AK10.62128169
101GRK70.61733475
102MAPKAPK50.60096685
103FGFR10.59603404
104MOS0.57343011
105MAP2K40.56545567
106NEK90.56122873
107CHEK10.54971849
108PLK10.53962144
109MAP3K80.53783594
110SGK10.53578633
111TRPM70.53113711
112MATK0.52406049
113ATM0.51587205
114STK40.50331485
115SGK30.49271309
116ATR0.49178601
117PRKCE0.45779000
118PIM10.45406181
119TRIM280.44509823
120BRSK10.43077649
121* CSNK1E0.42357780
122PIM20.42110586
123JAK30.41739878
124NEK20.41394856
125PRKCH0.40110139
126RPS6KB10.39960770
127CDK90.39836586
128CSNK1G30.39600564
129WEE10.38287611
130EEF2K0.38201339
131DYRK1A0.37956350
132FGFR20.37391997
133MET0.37307324
134RAF10.37268370
135STK110.35747504
136CDK70.34898184
137PTK20.34849621
138ICK0.34275827
139CSNK1A1L0.32952403
140MTOR0.32597858
141CDK180.32584968
142AURKB0.32381824
143CDK40.32232280
144RET0.31738379
145TNK20.31638425
146* CSNK2A10.30818917
147CCNB10.30725869
148PAK20.30698804
149PRKG10.29685470
150AURKA0.28624281
151CAMK2B0.26731393
152LYN0.26189623
153PRKAA20.25411771

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030202.85836250
2Fanconi anemia pathway_Homo sapiens_hsa034602.84509402
3Homologous recombination_Homo sapiens_hsa034402.82512302
4* Basal transcription factors_Homo sapiens_hsa030222.49948876
5Non-homologous end-joining_Homo sapiens_hsa034502.29074773
6Phototransduction_Homo sapiens_hsa047442.24405932
7Adherens junction_Homo sapiens_hsa045202.16367582
8Protein export_Homo sapiens_hsa030602.08386791
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.97710296
10Dorso-ventral axis formation_Homo sapiens_hsa043201.95389265
11Chronic myeloid leukemia_Homo sapiens_hsa052201.94743252
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92080374
13Allograft rejection_Homo sapiens_hsa053301.89740117
14RNA degradation_Homo sapiens_hsa030181.85109792
15Autoimmune thyroid disease_Homo sapiens_hsa053201.83506877
16Renal cell carcinoma_Homo sapiens_hsa052111.82398177
17Mismatch repair_Homo sapiens_hsa034301.81473380
18Long-term potentiation_Homo sapiens_hsa047201.81391561
19Endometrial cancer_Homo sapiens_hsa052131.79426748
20DNA replication_Homo sapiens_hsa030301.75531429
21Cell cycle_Homo sapiens_hsa041101.66440607
22Colorectal cancer_Homo sapiens_hsa052101.66087347
23Proteasome_Homo sapiens_hsa030501.65401176
24Arachidonic acid metabolism_Homo sapiens_hsa005901.64793158
25ErbB signaling pathway_Homo sapiens_hsa040121.63457751
26Glioma_Homo sapiens_hsa052141.59439922
27Base excision repair_Homo sapiens_hsa034101.59279524
28Ether lipid metabolism_Homo sapiens_hsa005651.51376576
29Nucleotide excision repair_Homo sapiens_hsa034201.46300365
30Spliceosome_Homo sapiens_hsa030401.45910339
31Oocyte meiosis_Homo sapiens_hsa041141.44308681
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.43119261
33Estrogen signaling pathway_Homo sapiens_hsa049151.41954085
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41838878
35Sphingolipid metabolism_Homo sapiens_hsa006001.41086249
36Graft-versus-host disease_Homo sapiens_hsa053321.40203374
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.39237711
38Hedgehog signaling pathway_Homo sapiens_hsa043401.37170053
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.36299020
40Pancreatic cancer_Homo sapiens_hsa052121.33947982
41Non-small cell lung cancer_Homo sapiens_hsa052231.29149066
42Gap junction_Homo sapiens_hsa045401.28675755
43Asthma_Homo sapiens_hsa053101.28439417
44Pyrimidine metabolism_Homo sapiens_hsa002401.27270324
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26842047
46Hippo signaling pathway_Homo sapiens_hsa043901.26645964
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23778510
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23494996
49Purine metabolism_Homo sapiens_hsa002301.22083464
50Proteoglycans in cancer_Homo sapiens_hsa052051.21403576
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17975767
52Small cell lung cancer_Homo sapiens_hsa052221.16883440
53Thyroid cancer_Homo sapiens_hsa052161.16312609
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.15832929
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15786482
56p53 signaling pathway_Homo sapiens_hsa041151.15076719
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11623778
58Neurotrophin signaling pathway_Homo sapiens_hsa047221.10966672
59Herpes simplex infection_Homo sapiens_hsa051681.10398699
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08662398
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06030805
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05984849
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03855414
64RNA transport_Homo sapiens_hsa030131.03141332
65Rheumatoid arthritis_Homo sapiens_hsa053231.02734790
66Measles_Homo sapiens_hsa051621.02723509
67Inositol phosphate metabolism_Homo sapiens_hsa005621.02722862
68Central carbon metabolism in cancer_Homo sapiens_hsa052301.01539586
69Type II diabetes mellitus_Homo sapiens_hsa049301.00027081
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99523702
71Melanogenesis_Homo sapiens_hsa049160.98989114
72Linoleic acid metabolism_Homo sapiens_hsa005910.98672975
73Alcoholism_Homo sapiens_hsa050340.97104209
74FoxO signaling pathway_Homo sapiens_hsa040680.96556842
75mTOR signaling pathway_Homo sapiens_hsa041500.96346875
76Primary immunodeficiency_Homo sapiens_hsa053400.94273218
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.91170243
78* Viral carcinogenesis_Homo sapiens_hsa052030.90700964
79Focal adhesion_Homo sapiens_hsa045100.89515193
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89465526
81Serotonergic synapse_Homo sapiens_hsa047260.89169266
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88381924
83mRNA surveillance pathway_Homo sapiens_hsa030150.87698340
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87126686
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86799196
86Huntingtons disease_Homo sapiens_hsa050160.86472051
87Oxidative phosphorylation_Homo sapiens_hsa001900.86292219
88Glutamatergic synapse_Homo sapiens_hsa047240.86171665
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83666991
90Tight junction_Homo sapiens_hsa045300.83253401
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82714030
92Steroid biosynthesis_Homo sapiens_hsa001000.81317318
93GnRH signaling pathway_Homo sapiens_hsa049120.81260398
94Epstein-Barr virus infection_Homo sapiens_hsa051690.80608966
95Bladder cancer_Homo sapiens_hsa052190.80399119
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79294115
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79113650
98Cholinergic synapse_Homo sapiens_hsa047250.78936970
99Influenza A_Homo sapiens_hsa051640.78767132
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77887308
101VEGF signaling pathway_Homo sapiens_hsa043700.76017173
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.75974593
103Dopaminergic synapse_Homo sapiens_hsa047280.75779815
104Olfactory transduction_Homo sapiens_hsa047400.75425596
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.74718901
106Selenocompound metabolism_Homo sapiens_hsa004500.74082351
107Choline metabolism in cancer_Homo sapiens_hsa052310.73510288
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73446924
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73162844
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72641950
111Insulin signaling pathway_Homo sapiens_hsa049100.72238748
112Cocaine addiction_Homo sapiens_hsa050300.71889248
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71438319
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.71380571
115Amphetamine addiction_Homo sapiens_hsa050310.70616985
116Prion diseases_Homo sapiens_hsa050200.70449438
117Acute myeloid leukemia_Homo sapiens_hsa052210.68994579
118Type I diabetes mellitus_Homo sapiens_hsa049400.67682058
119MAPK signaling pathway_Homo sapiens_hsa040100.67637386
120Rap1 signaling pathway_Homo sapiens_hsa040150.65785676
121B cell receptor signaling pathway_Homo sapiens_hsa046620.65628851
122Thyroid hormone synthesis_Homo sapiens_hsa049180.64523275
123Malaria_Homo sapiens_hsa051440.64189771
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63837432
125Hematopoietic cell lineage_Homo sapiens_hsa046400.63003524
126Melanoma_Homo sapiens_hsa052180.61795057
127Prostate cancer_Homo sapiens_hsa052150.61758809
128Ovarian steroidogenesis_Homo sapiens_hsa049130.61239799
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60927483
130Notch signaling pathway_Homo sapiens_hsa043300.60119863
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59617306
132Leishmaniasis_Homo sapiens_hsa051400.58088273
133Amoebiasis_Homo sapiens_hsa051460.57741615
134Taste transduction_Homo sapiens_hsa047420.55257850
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55176996
136Parkinsons disease_Homo sapiens_hsa050120.54886915
137HIF-1 signaling pathway_Homo sapiens_hsa040660.54796072
138Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53828215
139Lysine degradation_Homo sapiens_hsa003100.53674720
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53625037
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53434235
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51669417
143Phagosome_Homo sapiens_hsa041450.51548046
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51409562
145Systemic lupus erythematosus_Homo sapiens_hsa053220.50448793
146TGF-beta signaling pathway_Homo sapiens_hsa043500.50012219
147Nicotine addiction_Homo sapiens_hsa050330.49965369
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49356114
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48765882
150Circadian rhythm_Homo sapiens_hsa047100.48497751
151ECM-receptor interaction_Homo sapiens_hsa045120.48495011
152Antigen processing and presentation_Homo sapiens_hsa046120.47886236
153Regulation of autophagy_Homo sapiens_hsa041400.46302371
154Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44559924
155Chemokine signaling pathway_Homo sapiens_hsa040620.44295777
156Hepatitis B_Homo sapiens_hsa051610.41832200
157Ribosome_Homo sapiens_hsa030100.41327878
158Axon guidance_Homo sapiens_hsa043600.41303791
159MicroRNAs in cancer_Homo sapiens_hsa052060.40674251
160Ras signaling pathway_Homo sapiens_hsa040140.40060290
161Other glycan degradation_Homo sapiens_hsa005110.38796410
162Alzheimers disease_Homo sapiens_hsa050100.38785517
163Pathways in cancer_Homo sapiens_hsa052000.36515089
164Wnt signaling pathway_Homo sapiens_hsa043100.35746966
165Pertussis_Homo sapiens_hsa051330.34550922
166Apoptosis_Homo sapiens_hsa042100.34385852
167Prolactin signaling pathway_Homo sapiens_hsa049170.34341072
168Basal cell carcinoma_Homo sapiens_hsa052170.34260542
169HTLV-I infection_Homo sapiens_hsa051660.33291849
170Long-term depression_Homo sapiens_hsa047300.33287281

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