GTF2A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.39954341
2ribosomal small subunit assembly (GO:0000028)5.31455231
3ATP synthesis coupled proton transport (GO:0015986)5.28176522
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.28176522
5ribosomal small subunit biogenesis (GO:0042274)4.67731316
6protein complex biogenesis (GO:0070271)4.50418865
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.49610045
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.49610045
9NADH dehydrogenase complex assembly (GO:0010257)4.49610045
10proteasome assembly (GO:0043248)4.42050814
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.36627038
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.28336721
13cotranslational protein targeting to membrane (GO:0006613)4.25628682
14viral transcription (GO:0019083)4.23886869
15protein neddylation (GO:0045116)4.21839080
16respiratory chain complex IV assembly (GO:0008535)4.19174821
17protein targeting to ER (GO:0045047)4.17887982
18mitochondrial respiratory chain complex assembly (GO:0033108)4.16469609
19CENP-A containing nucleosome assembly (GO:0034080)4.15186575
20translational termination (GO:0006415)4.13430755
21telomere maintenance via semi-conservative replication (GO:0032201)4.09402789
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.06876167
23protein localization to endoplasmic reticulum (GO:0070972)4.03452840
24chaperone-mediated protein transport (GO:0072321)4.01623194
25respiratory electron transport chain (GO:0022904)4.00585509
26chromatin remodeling at centromere (GO:0031055)3.95877105
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.95746351
28DNA deamination (GO:0045006)3.92692190
29electron transport chain (GO:0022900)3.91667863
30telomere maintenance via recombination (GO:0000722)3.82891182
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.80733273
32termination of RNA polymerase III transcription (GO:0006386)3.80733273
337-methylguanosine mRNA capping (GO:0006370)3.80326359
34GTP biosynthetic process (GO:0006183)3.79512788
357-methylguanosine RNA capping (GO:0009452)3.79463651
36RNA capping (GO:0036260)3.79463651
37cullin deneddylation (GO:0010388)3.76230907
38DNA double-strand break processing (GO:0000729)3.70365300
39cytochrome complex assembly (GO:0017004)3.69366251
40protein deneddylation (GO:0000338)3.68758339
41exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.67207116
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67122589
43ribosomal large subunit biogenesis (GO:0042273)3.64561148
44establishment of integrated proviral latency (GO:0075713)3.63923328
45tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.63133988
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.63133988
47regulation of mitochondrial translation (GO:0070129)3.61939680
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59332960
49transcription-coupled nucleotide-excision repair (GO:0006283)3.54856679
50translation (GO:0006412)3.54394615
51positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.52567855
52translational elongation (GO:0006414)3.52291967
53DNA damage response, detection of DNA damage (GO:0042769)3.52170173
54maturation of SSU-rRNA (GO:0030490)3.47157256
55protein localization to mitochondrion (GO:0070585)3.45150877
56rRNA modification (GO:0000154)3.44899334
57DNA strand elongation involved in DNA replication (GO:0006271)3.44504016
58guanosine-containing compound biosynthetic process (GO:1901070)3.44327699
59mitotic recombination (GO:0006312)3.43665165
60DNA strand elongation (GO:0022616)3.40784650
61inner mitochondrial membrane organization (GO:0007007)3.40173431
62spliceosomal snRNP assembly (GO:0000387)3.39006122
63positive regulation of ligase activity (GO:0051351)3.38937818
64deoxyribose phosphate biosynthetic process (GO:0046385)3.38090883
652-deoxyribonucleotide biosynthetic process (GO:0009265)3.38090883
66water-soluble vitamin biosynthetic process (GO:0042364)3.36537935
67protein-cofactor linkage (GO:0018065)3.35619523
68kinetochore organization (GO:0051383)3.34511577
69nucleotide-excision repair, DNA gap filling (GO:0006297)3.34382155
70cellular protein complex disassembly (GO:0043624)3.33685128
71viral life cycle (GO:0019058)3.33353075
72regulation of cellular amino acid metabolic process (GO:0006521)3.32535098
73establishment of protein localization to mitochondrial membrane (GO:0090151)3.32102786
74pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.31550545
75DNA replication-independent nucleosome assembly (GO:0006336)3.30380854
76DNA replication-independent nucleosome organization (GO:0034724)3.30380854
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30291038
78positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29843900
79negative regulation of ligase activity (GO:0051352)3.28451941
80negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28451941
81protein targeting to mitochondrion (GO:0006626)3.27968645
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26989925
83kinetochore assembly (GO:0051382)3.26071110
84ATP biosynthetic process (GO:0006754)3.23401413
85signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.21906519
86intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.21906519
87pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21790899
88viral mRNA export from host cell nucleus (GO:0046784)3.21729925
89hydrogen ion transmembrane transport (GO:1902600)3.20714663
90pseudouridine synthesis (GO:0001522)3.20706243
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.20661579
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.20661579
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.20661579
94intracellular protein transmembrane import (GO:0044743)3.20403916
95spliceosomal complex assembly (GO:0000245)3.18789252
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18176227
97histone mRNA metabolic process (GO:0008334)3.17215451
98antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.16505643
99deoxyribonucleotide biosynthetic process (GO:0009263)3.16315161
100oxidative phosphorylation (GO:0006119)3.16235750
101purine nucleoside triphosphate biosynthetic process (GO:0009145)3.15948796
102UTP biosynthetic process (GO:0006228)3.14930982
103platelet dense granule organization (GO:0060155)3.14539904
104maturation of 5.8S rRNA (GO:0000460)3.14077703
105signal peptide processing (GO:0006465)3.13634521
106transcription elongation from RNA polymerase I promoter (GO:0006362)3.13631089
107translational initiation (GO:0006413)3.12952732
108purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.12288437
109histone exchange (GO:0043486)3.11683251
110rRNA methylation (GO:0031167)3.11492765
111nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11337964
112regulation of ubiquitin-protein transferase activity (GO:0051438)3.10747351
113DNA catabolic process, exonucleolytic (GO:0000738)3.09494604
114telomere maintenance via telomere lengthening (GO:0010833)3.09388122
115peptidyl-histidine modification (GO:0018202)3.08534451
116establishment of protein localization to mitochondrion (GO:0072655)3.07647480
117establishment of viral latency (GO:0019043)3.06414231
118DNA replication initiation (GO:0006270)3.05611270
119termination of RNA polymerase I transcription (GO:0006363)3.05422299
120signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04997962
121signal transduction involved in DNA damage checkpoint (GO:0072422)3.04997962
122signal transduction involved in cell cycle checkpoint (GO:0072395)3.04385706
123deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.03454578
124regulation of ligase activity (GO:0051340)3.01109680
125cellular component biogenesis (GO:0044085)2.95070184
126proton transport (GO:0015992)2.92446057
127mitochondrial transport (GO:0006839)2.90201659
128rRNA processing (GO:0006364)2.88689325
129regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.87219074
130regulation of mitotic spindle checkpoint (GO:1903504)2.87219074
131DNA replication checkpoint (GO:0000076)2.86076389
132hydrogen transport (GO:0006818)2.85851657
133regulation of cellular amine metabolic process (GO:0033238)2.84026834
134ribosome assembly (GO:0042255)2.82619428
135purine nucleobase biosynthetic process (GO:0009113)2.81613712

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.83211113
2E2F7_22180533_ChIP-Seq_HELA_Human4.38844997
3* GABP_17652178_ChIP-ChIP_JURKAT_Human4.32526167
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.11930766
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.96352760
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.61449958
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.51692259
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.25798649
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14536441
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.08483196
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.07025725
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.04799354
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02720186
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.97329805
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.81883316
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.68488274
17VDR_23849224_ChIP-Seq_CD4+_Human2.67624627
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58325899
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58324406
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53665087
21ELK1_19687146_ChIP-ChIP_HELA_Human2.50654033
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.47427787
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.41751619
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38419898
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33990516
26DCP1A_22483619_ChIP-Seq_HELA_Human2.31259495
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.29490567
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14962646
29FOXP3_21729870_ChIP-Seq_TREG_Human2.11642270
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09408647
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06952056
32ZNF274_21170338_ChIP-Seq_K562_Hela2.04903530
33HOXB4_20404135_ChIP-ChIP_EML_Mouse2.02271809
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99146747
35XRN2_22483619_ChIP-Seq_HELA_Human1.97822422
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97363968
37* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90662770
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90628231
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84972776
40TTF2_22483619_ChIP-Seq_HELA_Human1.84153431
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83671580
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.83611364
43* GABP_19822575_ChIP-Seq_HepG2_Human1.79964308
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69693856
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65390406
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62654642
47* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.58811254
48IRF1_19129219_ChIP-ChIP_H3396_Human1.58475157
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57225373
50* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54341362
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40230951
52IGF1R_20145208_ChIP-Seq_DFB_Human1.38155118
53MYC_18940864_ChIP-ChIP_HL60_Human1.36072185
54* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35897613
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34689607
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31537132
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31261827
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.26798206
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26387839
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.21710377
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21419664
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.18484560
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17572144
64EWS_26573619_Chip-Seq_HEK293_Human1.17514796
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17465116
66FUS_26573619_Chip-Seq_HEK293_Human1.15662843
67P300_19829295_ChIP-Seq_ESCs_Human1.15646316
68* TP53_22573176_ChIP-Seq_HFKS_Human1.12670618
69HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12097615
70AR_21909140_ChIP-Seq_LNCAP_Human1.11642156
71VDR_22108803_ChIP-Seq_LS180_Human1.11355116
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10806342
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10779678
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10229881
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09911529
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.09868117
77FOXM1_23109430_ChIP-Seq_U2OS_Human1.09185467
78* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08119225
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06682972
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06472738
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.05475354
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04756445
83* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02883113
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.00013518
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98485095
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97625615
87SOX2_16153702_ChIP-ChIP_HESCs_Human0.96480784
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95173089
89ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95171794
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93931314
91NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93178285
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92869543
93SOX2_19829295_ChIP-Seq_ESCs_Human0.92792812
94NANOG_19829295_ChIP-Seq_ESCs_Human0.92792812
95CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92202496
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92080286
97* SOX17_20123909_ChIP-Seq_XEN_Mouse0.89278668
98HTT_18923047_ChIP-ChIP_STHdh_Human0.88940995
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88257082
100FOXA1_25329375_ChIP-Seq_VCAP_Human0.88257082
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87086396
102BP1_19119308_ChIP-ChIP_Hs578T_Human0.86953409
103KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86748674
104BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86492342
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86015646
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85806460
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85034132
108PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84367885
109KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84345528
110TAF15_26573619_Chip-Seq_HEK293_Human0.83893409
111CIITA_25753668_ChIP-Seq_RAJI_Human0.83883670
112SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81151736
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80953859
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.80877063
115AR_20517297_ChIP-Seq_VCAP_Human0.80250533
116* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78712297
117EZH2_27294783_Chip-Seq_NPCs_Mouse0.77844827
118KDM5A_27292631_Chip-Seq_BREAST_Human0.77439930
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76312641
120TP63_19390658_ChIP-ChIP_HaCaT_Human0.72788440
121* SPI1_23547873_ChIP-Seq_NB4_Human0.71751310
122CTCF_18555785_ChIP-Seq_MESCs_Mouse0.69548701
123FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68944283
124NFE2_27457419_Chip-Seq_LIVER_Mouse0.67204026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.98185687
2MP0003693_abnormal_embryo_hatching3.51358690
3MP0010094_abnormal_chromosome_stability2.99491330
4MP0006292_abnormal_olfactory_placode2.99368940
5MP0008058_abnormal_DNA_repair2.93942382
6MP0004957_abnormal_blastocyst_morpholog2.71325963
7MP0009697_abnormal_copulation2.60306510
8MP0002102_abnormal_ear_morphology2.48861565
9MP0001529_abnormal_vocalization2.46983374
10MP0008057_abnormal_DNA_replication2.40537748
11MP0004147_increased_porphyrin_level2.39112830
12MP0003077_abnormal_cell_cycle2.22787710
13MP0002837_dystrophic_cardiac_calcinosis2.18276379
14MP0002938_white_spotting2.16553415
15MP0008932_abnormal_embryonic_tissue2.16161823
16MP0008789_abnormal_olfactory_epithelium2.02391002
17MP0001986_abnormal_taste_sensitivity1.98386916
18MP0003786_premature_aging1.91250412
19MP0002638_abnormal_pupillary_reflex1.90753773
20MP0000372_irregular_coat_pigmentation1.90416091
21MP0003111_abnormal_nucleus_morphology1.86869032
22MP0001188_hyperpigmentation1.84164192
23MP0006036_abnormal_mitochondrial_physio1.82191952
24MP0002736_abnormal_nociception_after1.81969354
25MP0003186_abnormal_redox_activity1.80852021
26MP0001905_abnormal_dopamine_level1.80257559
27MP0003806_abnormal_nucleotide_metabolis1.77409065
28MP0003195_calcinosis1.72745583
29MP0003880_abnormal_central_pattern1.71968899
30MP0008877_abnormal_DNA_methylation1.71800278
31MP0003718_maternal_effect1.71398881
32MP0008007_abnormal_cellular_replicative1.66153806
33MP0006054_spinal_hemorrhage1.65548795
34MP0003136_yellow_coat_color1.59740734
35MP0002132_abnormal_respiratory_system1.57441233
36MP0003011_delayed_dark_adaptation1.54531256
37MP0002095_abnormal_skin_pigmentation1.49963374
38MP0000566_synostosis1.49654585
39MP0005408_hypopigmentation1.49192834
40MP0000015_abnormal_ear_pigmentation1.47958295
41MP0002163_abnormal_gland_morphology1.46402942
42MP0002160_abnormal_reproductive_system1.44222558
43MP0008995_early_reproductive_senescence1.44082596
44MP0003315_abnormal_perineum_morphology1.43792386
45MP0001293_anophthalmia1.43093655
46MP0005084_abnormal_gallbladder_morpholo1.38535977
47MP0005409_darkened_coat_color1.38263303
48MP0003890_abnormal_embryonic-extraembry1.37580597
49MP0006035_abnormal_mitochondrial_morpho1.35629952
50MP0005551_abnormal_eye_electrophysiolog1.35577190
51MP0008872_abnormal_physiological_respon1.35258316
52MP0005075_abnormal_melanosome_morpholog1.35109980
53MP0005379_endocrine/exocrine_gland_phen1.33857887
54MP0002277_abnormal_respiratory_mucosa1.33113376
55MP0010386_abnormal_urinary_bladder1.32496053
56MP0006276_abnormal_autonomic_nervous1.31261623
57MP0001968_abnormal_touch/_nociception1.30052720
58MP0006072_abnormal_retinal_apoptosis1.29034147
59MP0003763_abnormal_thymus_physiology1.28154080
60MP0005389_reproductive_system_phenotype1.22104943
61MP0005394_taste/olfaction_phenotype1.19026259
62MP0005499_abnormal_olfactory_system1.19026259
63MP0003656_abnormal_erythrocyte_physiolo1.18089358
64MP0001764_abnormal_homeostasis1.17535337
65MP0003567_abnormal_fetal_cardiomyocyte1.17368228
66MP0000678_abnormal_parathyroid_gland1.15930497
67MP0002210_abnormal_sex_determination1.13837709
68MP0004215_abnormal_myocardial_fiber1.13425411
69MP0003121_genomic_imprinting1.07500674
70MP0002396_abnormal_hematopoietic_system1.07434609
71MP0000490_abnormal_crypts_of1.06386219
72MP0005171_absent_coat_pigmentation1.05209651
73MP0008875_abnormal_xenobiotic_pharmacok1.03426839
74MP0002234_abnormal_pharynx_morphology1.02739727
75MP0002090_abnormal_vision1.02019212
76MP0003941_abnormal_skin_development1.01641666
77MP0000049_abnormal_middle_ear1.00073899
78MP0009046_muscle_twitch1.00042233
79MP0001929_abnormal_gametogenesis0.99757660
80MP0003646_muscle_fatigue0.99265518
81MP0000631_abnormal_neuroendocrine_gland0.98623536
82MP0000358_abnormal_cell_content/0.95685602
83MP0001485_abnormal_pinna_reflex0.94431475
84MP0005646_abnormal_pituitary_gland0.94379971
85MP0000653_abnormal_sex_gland0.94040575
86MP0001119_abnormal_female_reproductive0.93071053
87MP0009333_abnormal_splenocyte_physiolog0.92679012
88MP0003119_abnormal_digestive_system0.92243562
89MP0003787_abnormal_imprinting0.92125001
90MP0001145_abnormal_male_reproductive0.91280119
91MP0003937_abnormal_limbs/digits/tail_de0.91003491
92MP0000516_abnormal_urinary_system0.90690708
93MP0005367_renal/urinary_system_phenotyp0.90690708
94MP0002751_abnormal_autonomic_nervous0.90476418
95MP0001853_heart_inflammation0.89621023
96MP0000647_abnormal_sebaceous_gland0.88604932
97MP0005410_abnormal_fertilization0.87155897
98MP0005174_abnormal_tail_pigmentation0.84641321
99MP0005332_abnormal_amino_acid0.84466477
100MP0002272_abnormal_nervous_system0.83882800
101MP0004145_abnormal_muscle_electrophysio0.83520042
102MP0004142_abnormal_muscle_tone0.81877733
103MP0003137_abnormal_impulse_conducting0.80423040
104MP0001919_abnormal_reproductive_system0.80007840
105MP0004134_abnormal_chest_morphology0.79933204
106MP0005671_abnormal_response_to0.79089970
107MP0002876_abnormal_thyroid_physiology0.78138971
108MP0002009_preneoplasia0.77654163
109MP0005253_abnormal_eye_physiology0.77611864
110MP0002148_abnormal_hypersensitivity_rea0.77467716
111MP0000026_abnormal_inner_ear0.76728100
112MP0001186_pigmentation_phenotype0.74846309
113MP0000313_abnormal_cell_death0.74524300
114MP0002233_abnormal_nose_morphology0.74181983
115MP0004133_heterotaxia0.74122485
116MP0002177_abnormal_outer_ear0.73074656
117MP0005645_abnormal_hypothalamus_physiol0.72903161
118MP0002822_catalepsy0.71568329
119MP0001835_abnormal_antigen_presentation0.71407386
120MP0001286_abnormal_eye_development0.71126688
121MP0005636_abnormal_mineral_homeostasis0.69991095
122MP0003724_increased_susceptibility_to0.69375364
123MP0001984_abnormal_olfaction0.68210650
124MP0000681_abnormal_thyroid_gland0.67972725
125MP0005391_vision/eye_phenotype0.67680252
126MP0009785_altered_susceptibility_to0.66990848
127MP0003698_abnormal_male_reproductive0.65188733
128MP0002693_abnormal_pancreas_physiology0.64816644
129MP0002398_abnormal_bone_marrow0.63757095
130MP0001727_abnormal_embryo_implantation0.63617558
131MP0005451_abnormal_body_composition0.63468435
132MP0004381_abnormal_hair_follicle0.63451883
133MP0004782_abnormal_surfactant_physiolog0.62325641

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.43251613
2Abnormal mitochondria in muscle tissue (HP:0008316)4.95527328
3Mitochondrial inheritance (HP:0001427)4.91127046
4Abnormality of cells of the erythroid lineage (HP:0012130)4.60363027
5Abnormal number of erythroid precursors (HP:0012131)4.54367121
6Progressive macrocephaly (HP:0004481)4.48190607
7Hepatocellular necrosis (HP:0001404)4.27053694
8Acute encephalopathy (HP:0006846)4.21924611
9Increased CSF lactate (HP:0002490)4.21429948
103-Methylglutaconic aciduria (HP:0003535)4.18249346
11Increased hepatocellular lipid droplets (HP:0006565)4.12697039
12Renal Fanconi syndrome (HP:0001994)4.01022880
13Hepatic necrosis (HP:0002605)3.75207374
14Lipid accumulation in hepatocytes (HP:0006561)3.71604277
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.71028187
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.71028187
17Birth length less than 3rd percentile (HP:0003561)3.67391497
18Abnormality of the heme biosynthetic pathway (HP:0010472)3.52748236
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.49192736
20Reticulocytopenia (HP:0001896)3.44606188
21Aplastic anemia (HP:0001915)3.37557973
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.37161029
23Exertional dyspnea (HP:0002875)3.26752869
24Methylmalonic acidemia (HP:0002912)3.21306479
25Increased serum lactate (HP:0002151)3.00705909
26Exercise intolerance (HP:0003546)2.95457921
27Congenital, generalized hypertrichosis (HP:0004540)2.93035143
28Increased intramyocellular lipid droplets (HP:0012240)2.92743415
29Methylmalonic aciduria (HP:0012120)2.87595211
30Type I transferrin isoform profile (HP:0003642)2.78505990
31Respiratory difficulties (HP:0002880)2.77414637
32Optic disc pallor (HP:0000543)2.76797367
33Abnormality of renal resorption (HP:0011038)2.64835726
34Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63622207
35Macrocytic anemia (HP:0001972)2.61868153
36Lactic acidosis (HP:0003128)2.61141789
37Increased serum pyruvate (HP:0003542)2.60131890
38Abnormality of glycolysis (HP:0004366)2.60131890
39Respiratory failure (HP:0002878)2.58308661
40Cerebral edema (HP:0002181)2.54252345
41Pallor (HP:0000980)2.54087679
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50625670
43Abnormality of alanine metabolism (HP:0010916)2.50625670
44Hyperalaninemia (HP:0003348)2.50625670
45True hermaphroditism (HP:0010459)2.43243347
46Lethargy (HP:0001254)2.41558280
47Hyperglycinemia (HP:0002154)2.39312096
48Increased muscle lipid content (HP:0009058)2.38295590
49Medial flaring of the eyebrow (HP:0010747)2.37684313
5011 pairs of ribs (HP:0000878)2.31059073
51Microvesicular hepatic steatosis (HP:0001414)2.30101866
52Leukodystrophy (HP:0002415)2.29101909
53Degeneration of anterior horn cells (HP:0002398)2.26394775
54Pancreatic fibrosis (HP:0100732)2.23259592
55Abnormality of the labia minora (HP:0012880)2.22747089
56Abnormality of serum amino acid levels (HP:0003112)2.21822720
57Abnormality of the preputium (HP:0100587)2.20318600
58Chromsome breakage (HP:0040012)2.17272166
59Abnormality of methionine metabolism (HP:0010901)2.16621190
60Oral leukoplakia (HP:0002745)2.16367811
61Hypothermia (HP:0002045)2.15704954
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.15218466
63Irregular epiphyses (HP:0010582)2.07969332
64CNS demyelination (HP:0007305)2.05998239
65Breast hypoplasia (HP:0003187)2.03427289
66Abnormality of aspartate family amino acid metabolism (HP:0010899)2.03416551
67Pancreatic cysts (HP:0001737)2.01733553
68Abnormal lung lobation (HP:0002101)2.00958283
69X-linked dominant inheritance (HP:0001423)1.97098038
70Hyperphosphaturia (HP:0003109)1.96789758
71Aplasia/Hypoplasia of the tibia (HP:0005772)1.96035802
72Meckel diverticulum (HP:0002245)1.94951704
73Reduced antithrombin III activity (HP:0001976)1.93983617
74Abnormal protein N-linked glycosylation (HP:0012347)1.93975654
75Abnormal protein glycosylation (HP:0012346)1.93975654
76Abnormal glycosylation (HP:0012345)1.93975654
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93975654
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93387823
79Abnormality of urine glucose concentration (HP:0011016)1.91647975
80Glycosuria (HP:0003076)1.91647975
81Congenital primary aphakia (HP:0007707)1.90920242
82Abnormality of vitamin B metabolism (HP:0004340)1.90411457
83Abnormality of the axillary hair (HP:0100134)1.90193073
84Abnormality of secondary sexual hair (HP:0009888)1.90193073
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89198752
86Aplasia/hypoplasia of the uterus (HP:0008684)1.88682733
87Abnormality of chromosome stability (HP:0003220)1.88269891
88Abnormality of the ileum (HP:0001549)1.86763102
89Pendular nystagmus (HP:0012043)1.86315909
90Abnormality of the vitamin B12 metabolism (HP:0004341)1.86129395
91Nephrogenic diabetes insipidus (HP:0009806)1.85614264
92Abnormality of placental membranes (HP:0011409)1.85410737
93Amniotic constriction ring (HP:0009775)1.85410737
94Generalized aminoaciduria (HP:0002909)1.84380823
95Pancytopenia (HP:0001876)1.84029181
96Nephronophthisis (HP:0000090)1.83548996
97Gait imbalance (HP:0002141)1.82306806
98Abnormal hair whorl (HP:0010721)1.80770168
99Abnormal respiratory motile cilium morphology (HP:0005938)1.80704882
100Abnormal respiratory epithelium morphology (HP:0012253)1.80704882
101Patchy hypopigmentation of hair (HP:0011365)1.80218136
102IgM deficiency (HP:0002850)1.79594032
103Type 2 muscle fiber atrophy (HP:0003554)1.78943809
104Nephroblastoma (Wilms tumor) (HP:0002667)1.77131953
105Aplasia/Hypoplasia of the uvula (HP:0010293)1.77116160
106Patellar aplasia (HP:0006443)1.75143146
107Rough bone trabeculation (HP:0100670)1.74257372
108Cerebral hypomyelination (HP:0006808)1.73695079
109Dicarboxylic aciduria (HP:0003215)1.71464083
110Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71464083
111Sclerocornea (HP:0000647)1.70737632
112Abolished electroretinogram (ERG) (HP:0000550)1.70320057
113Hypoplasia of the fovea (HP:0007750)1.70291258
114Aplasia/Hypoplasia of the fovea (HP:0008060)1.70291258
115Abnormality of midbrain morphology (HP:0002418)1.68417702
116Molar tooth sign on MRI (HP:0002419)1.68417702
117Hypoglycemic coma (HP:0001325)1.67881522
118Short tibia (HP:0005736)1.67309099
119Renal tubular dysfunction (HP:0000124)1.67242101
120Triphalangeal thumb (HP:0001199)1.66972031
121Megaloblastic anemia (HP:0001889)1.65469821
122Median cleft lip (HP:0000161)1.65034945
123Absent/shortened dynein arms (HP:0200106)1.63766468
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.63766468
125Premature graying of hair (HP:0002216)1.63219907
126Emotional lability (HP:0000712)1.62519945
127Embryonal renal neoplasm (HP:0011794)1.61457743
128Duplicated collecting system (HP:0000081)1.61220275
129Aplasia/Hypoplasia of the patella (HP:0006498)1.60814564
130Septo-optic dysplasia (HP:0100842)1.60792404
131Small intestinal stenosis (HP:0012848)1.60095852
132Duodenal stenosis (HP:0100867)1.60095852
133Colon cancer (HP:0003003)1.57163868
134Abnormality of the anterior horn cell (HP:0006802)1.56995122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.77471981
2VRK23.44598043
3BUB13.18148525
4SRPK12.83166357
5NME22.70579549
6VRK12.69601524
7EIF2AK32.65010608
8EIF2AK12.53241238
9NEK12.52910101
10TRIM282.49846851
11MAP4K22.32609476
12MST42.31895567
13WEE12.22044371
14PLK42.16337477
15WNK32.05666186
16TNIK1.92931631
17MKNK11.87855973
18PBK1.87221440
19BMPR1B1.75586690
20NME11.72805191
21TSSK61.72034464
22CCNB11.67888525
23CDK81.65991387
24ZAK1.64503878
25CASK1.56422428
26BRSK21.55316956
27ACVR1B1.55219180
28PDK21.52870291
29MKNK21.52312125
30CDC71.48737544
31BMPR21.42675029
32FRK1.37971719
33TLK11.35806472
34MAP2K71.33124532
35MUSK1.30953652
36BCKDK1.28786410
37DYRK21.26990558
38BCR1.25339355
39PIM21.24061601
40INSRR1.23711686
41CDK31.21085110
42MAP3K121.19775377
43IRAK41.16635701
44ADRBK21.15737549
45ERBB31.14550216
46BRAF1.13848917
47DYRK31.12637608
48TAF11.10052125
49OXSR11.09832938
50EIF2AK21.08629087
51YES11.08560170
52MAPK131.07798298
53PLK11.04240287
54MAP3K41.03032689
55TEC1.00971480
56AURKB0.96432108
57SIK30.95549616
58PIK3CG0.94517063
59TTK0.93095906
60CSNK1G30.91220825
61MAPKAPK50.91003526
62LIMK10.90845675
63TXK0.89428553
64MYLK0.89322666
65PLK30.87472873
66NEK60.86107077
67AURKA0.85976868
68ATR0.82664823
69PASK0.81589448
70BRSK10.79358220
71NUAK10.77101055
72CSNK2A10.76506217
73WNK40.76487702
74CDK70.76099323
75CLK10.74535625
76CHEK20.74517552
77OBSCN0.70258209
78KDR0.68385868
79RPS6KA50.66865416
80TGFBR10.65199374
81MAP3K60.64507885
82CSNK1G10.63229233
83ARAF0.62022227
84GRK70.61860416
85PRKCG0.60909125
86PNCK0.58542577
87RPS6KA40.58394473
88TESK10.58306884
89NLK0.58257345
90PIK3CA0.57665453
91CSNK2A20.57539456
92IRAK30.56501103
93PRKCE0.55773687
94TESK20.55256878
95CSNK1A1L0.50402862
96STK240.49315359
97BTK0.48853076
98LYN0.48651424
99STK40.47553377
100MINK10.46398664
101ERBB40.45526734
102PRKCI0.45422663
103RPS6KB20.44913990
104CSNK1G20.44287167
105ATM0.43061056
106PINK10.42851721
107ADRBK10.42846466
108ILK0.42844161
109STK390.42344151
110DAPK10.41652663
111TNK20.40674321
112IRAK20.40311032
113ABL20.37712572
114TRPM70.37445699
115UHMK10.37125865
116PLK20.36764846
117STK30.36502347
118STK38L0.36202925
119FLT30.35977310
120CDK190.35605880
121TIE10.35570606
122NEK20.35267592
123GRK10.34533924
124CSNK1A10.34246009
125CSNK1E0.34029555
126PIM10.33457169
127PAK10.32163470
128DAPK30.31653435
129SYK0.30728918
130PAK30.30614288
131IKBKB0.30567252

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.46063833
2Proteasome_Homo sapiens_hsa030503.88812608
3Oxidative phosphorylation_Homo sapiens_hsa001903.78671128
4Protein export_Homo sapiens_hsa030603.73415666
5DNA replication_Homo sapiens_hsa030303.63597725
6RNA polymerase_Homo sapiens_hsa030203.47341241
7Parkinsons disease_Homo sapiens_hsa050123.41809315
8Mismatch repair_Homo sapiens_hsa034303.29167450
9Homologous recombination_Homo sapiens_hsa034402.69558705
10Nucleotide excision repair_Homo sapiens_hsa034202.63729405
11Huntingtons disease_Homo sapiens_hsa050162.59892784
12Pyrimidine metabolism_Homo sapiens_hsa002402.54546071
13Spliceosome_Homo sapiens_hsa030402.45005242
14Alzheimers disease_Homo sapiens_hsa050102.38753039
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24109173
16Base excision repair_Homo sapiens_hsa034102.18550430
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.05270607
18Non-homologous end-joining_Homo sapiens_hsa034502.01918719
19Fanconi anemia pathway_Homo sapiens_hsa034601.94746187
20* Basal transcription factors_Homo sapiens_hsa030221.92596366
21RNA degradation_Homo sapiens_hsa030181.82009167
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63673752
23Propanoate metabolism_Homo sapiens_hsa006401.60321059
24Purine metabolism_Homo sapiens_hsa002301.54396934
25RNA transport_Homo sapiens_hsa030131.53897417
26Cell cycle_Homo sapiens_hsa041101.46921292
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43266430
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42675919
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36069544
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35167929
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28632910
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21535264
33Cardiac muscle contraction_Homo sapiens_hsa042601.05274792
34Butanoate metabolism_Homo sapiens_hsa006501.04418874
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02157290
36Maturity onset diabetes of the young_Homo sapiens_hsa049500.92705675
37One carbon pool by folate_Homo sapiens_hsa006700.89795826
38Sulfur metabolism_Homo sapiens_hsa009200.89602546
39Folate biosynthesis_Homo sapiens_hsa007900.86747120
40Arachidonic acid metabolism_Homo sapiens_hsa005900.81477990
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78980089
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78642083
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73688648
44Epstein-Barr virus infection_Homo sapiens_hsa051690.72359426
45Systemic lupus erythematosus_Homo sapiens_hsa053220.71609296
46Primary immunodeficiency_Homo sapiens_hsa053400.71210454
47Glutathione metabolism_Homo sapiens_hsa004800.71003771
48Metabolic pathways_Homo sapiens_hsa011000.69180016
49mRNA surveillance pathway_Homo sapiens_hsa030150.68615192
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67937095
51p53 signaling pathway_Homo sapiens_hsa041150.64041611
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63129043
53Fatty acid elongation_Homo sapiens_hsa000620.62984993
54Phototransduction_Homo sapiens_hsa047440.60581313
55Tryptophan metabolism_Homo sapiens_hsa003800.59590702
56Drug metabolism - other enzymes_Homo sapiens_hsa009830.58510249
57Sulfur relay system_Homo sapiens_hsa041220.57973902
58Caffeine metabolism_Homo sapiens_hsa002320.56995558
59Autoimmune thyroid disease_Homo sapiens_hsa053200.55551041
60Vitamin B6 metabolism_Homo sapiens_hsa007500.55422506
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55138009
62Nitrogen metabolism_Homo sapiens_hsa009100.54447598
63beta-Alanine metabolism_Homo sapiens_hsa004100.53324524
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53278021
65Linoleic acid metabolism_Homo sapiens_hsa005910.51564692
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50841565
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49493294
68Carbon metabolism_Homo sapiens_hsa012000.49334651
69N-Glycan biosynthesis_Homo sapiens_hsa005100.45378118
70Herpes simplex infection_Homo sapiens_hsa051680.45318765
71Sphingolipid metabolism_Homo sapiens_hsa006000.45284632
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.43200966
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.43105635
74Fatty acid degradation_Homo sapiens_hsa000710.43011034
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42646886
76Ether lipid metabolism_Homo sapiens_hsa005650.41614939
77Hematopoietic cell lineage_Homo sapiens_hsa046400.40923605
78Regulation of autophagy_Homo sapiens_hsa041400.40754617
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40249108
80Alcoholism_Homo sapiens_hsa050340.39267607
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38559066
82Fatty acid metabolism_Homo sapiens_hsa012120.38396327
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37545975
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37407401
85Allograft rejection_Homo sapiens_hsa053300.35503606
86Vibrio cholerae infection_Homo sapiens_hsa051100.34987913
87Steroid biosynthesis_Homo sapiens_hsa001000.34630460
88Olfactory transduction_Homo sapiens_hsa047400.32825493
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32106435
90Tyrosine metabolism_Homo sapiens_hsa003500.32025041
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30235699
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.29357166
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28986375
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28873928
95Nicotine addiction_Homo sapiens_hsa050330.28629632
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27518264
97Oocyte meiosis_Homo sapiens_hsa041140.27447190
98Biosynthesis of amino acids_Homo sapiens_hsa012300.27366008
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24834855
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.23993235
101Asthma_Homo sapiens_hsa053100.23859534
102Vitamin digestion and absorption_Homo sapiens_hsa049770.22766102
103Serotonergic synapse_Homo sapiens_hsa047260.22038401
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21522888
105Antigen processing and presentation_Homo sapiens_hsa046120.21440041
106Type I diabetes mellitus_Homo sapiens_hsa049400.21339633
107Chemical carcinogenesis_Homo sapiens_hsa052040.20683597
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19929614
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19760003
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.18376681
111Pyruvate metabolism_Homo sapiens_hsa006200.17681583
112Collecting duct acid secretion_Homo sapiens_hsa049660.17620750
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16517815
114Selenocompound metabolism_Homo sapiens_hsa004500.15956036
115Peroxisome_Homo sapiens_hsa041460.15213602
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14703015
117Arginine and proline metabolism_Homo sapiens_hsa003300.14446445
118Measles_Homo sapiens_hsa051620.13895187
119Graft-versus-host disease_Homo sapiens_hsa053320.12791570
120Rheumatoid arthritis_Homo sapiens_hsa053230.12308062
121Phagosome_Homo sapiens_hsa041450.10334100
122Other glycan degradation_Homo sapiens_hsa005110.09650481
123Retinol metabolism_Homo sapiens_hsa008300.09496088
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09164650
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07605824
126Phenylalanine metabolism_Homo sapiens_hsa003600.07495686

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