GTF2E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.16961449
2nuclear pore organization (GO:0006999)5.10219110
3DNA unwinding involved in DNA replication (GO:0006268)4.81337677
4DNA replication-dependent nucleosome organization (GO:0034723)4.76875569
5DNA replication-dependent nucleosome assembly (GO:0006335)4.76875569
6nuclear pore complex assembly (GO:0051292)4.70075793
7nucleobase biosynthetic process (GO:0046112)4.56112639
8regulation of mitotic spindle checkpoint (GO:1903504)4.50246985
9regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.50246985
10negative regulation of DNA-dependent DNA replication (GO:2000104)4.43756019
11IMP biosynthetic process (GO:0006188)4.43403953
12DNA replication initiation (GO:0006270)4.40034583
13DNA strand elongation involved in DNA replication (GO:0006271)4.38585138
14folic acid-containing compound biosynthetic process (GO:0009396)4.36814191
15mitotic metaphase plate congression (GO:0007080)4.32956401
16purine nucleobase biosynthetic process (GO:0009113)4.27158572
17mitotic nuclear envelope disassembly (GO:0007077)4.26527313
18protein localization to kinetochore (GO:0034501)4.24452531
19DNA strand elongation (GO:0022616)4.20199668
20DNA replication checkpoint (GO:0000076)4.14741092
21formation of translation preinitiation complex (GO:0001731)4.08534889
22ribosome assembly (GO:0042255)4.01951661
23nuclear envelope disassembly (GO:0051081)3.97601414
24membrane disassembly (GO:0030397)3.97601414
25IMP metabolic process (GO:0046040)3.94327875
26proteasome assembly (GO:0043248)3.84066541
27metaphase plate congression (GO:0051310)3.80560850
28telomere maintenance via semi-conservative replication (GO:0032201)3.73255012
29regulation of posttranscriptional gene silencing (GO:0060147)3.71429688
30regulation of gene silencing by miRNA (GO:0060964)3.71429688
31regulation of gene silencing by RNA (GO:0060966)3.71429688
32ribosome biogenesis (GO:0042254)3.70542869
33regulation of spindle organization (GO:0090224)3.69020243
34DNA catabolic process, exonucleolytic (GO:0000738)3.63959572
35pore complex assembly (GO:0046931)3.63193539
36regulation of histone H3-K9 methylation (GO:0051570)3.59988996
37DNA geometric change (GO:0032392)3.55634391
38DNA duplex unwinding (GO:0032508)3.54904230
39replication fork processing (GO:0031297)3.51934381
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.51090290
41protein localization to chromosome, centromeric region (GO:0071459)3.50419261
42maturation of SSU-rRNA (GO:0030490)3.50297322
43regulation of helicase activity (GO:0051095)3.49301689
44chromatin remodeling at centromere (GO:0031055)3.49247787
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.43457980
46DNA ligation (GO:0006266)3.43250596
47double-strand break repair via nonhomologous end joining (GO:0006303)3.37892946
48non-recombinational repair (GO:0000726)3.37892946
49regulation of centrosome cycle (GO:0046605)3.37276119
50DNA replication-independent nucleosome organization (GO:0034724)3.35832737
51DNA replication-independent nucleosome assembly (GO:0006336)3.35832737
52cullin deneddylation (GO:0010388)3.35370260
53CENP-A containing nucleosome assembly (GO:0034080)3.35131937
54DNA damage response, detection of DNA damage (GO:0042769)3.34035992
55establishment of chromosome localization (GO:0051303)3.32017701
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.31938581
57telomere maintenance via recombination (GO:0000722)3.31364723
58mitotic sister chromatid cohesion (GO:0007064)3.30676586
59positive regulation of chromosome segregation (GO:0051984)3.30524712
60mitotic sister chromatid segregation (GO:0000070)3.29407672
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.28323790
62regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.27567311
63mitotic recombination (GO:0006312)3.26264627
64somatic hypermutation of immunoglobulin genes (GO:0016446)3.25335301
65somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25335301
66meiotic chromosome segregation (GO:0045132)3.25173769
67spliceosomal snRNP assembly (GO:0000387)3.24919336
68regulation of centriole replication (GO:0046599)3.23810044
69regulation of mitotic spindle organization (GO:0060236)3.21531887
70telomere maintenance via telomere lengthening (GO:0010833)3.21093004
71regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20503337
72chaperone-mediated protein complex assembly (GO:0051131)3.20453436
73protein deneddylation (GO:0000338)3.19516932
74ribonucleoprotein complex biogenesis (GO:0022613)3.17771873
75negative regulation of histone methylation (GO:0031061)3.16533259
76mitotic chromosome condensation (GO:0007076)3.16122361
77kinetochore organization (GO:0051383)3.16109515
78response to X-ray (GO:0010165)3.15388551
79mitotic G2/M transition checkpoint (GO:0044818)3.14712600
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14304754
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.14244479
82somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.14244479
83isotype switching (GO:0045190)3.14244479
84regulation of mitotic sister chromatid separation (GO:0010965)3.13440920
85regulation of mitotic sister chromatid segregation (GO:0033047)3.13440920
86regulation of sister chromatid segregation (GO:0033045)3.13440920
87respiratory chain complex IV assembly (GO:0008535)3.12427531
88nucleotide-excision repair, DNA gap filling (GO:0006297)3.11876712
89nuclear envelope organization (GO:0006998)3.11224175
90attachment of spindle microtubules to kinetochore (GO:0008608)3.11152930
91regulation of DNA endoreduplication (GO:0032875)3.10353078
92recombinational repair (GO:0000725)3.09429076
93double-strand break repair via homologous recombination (GO:0000724)3.08106882
94synapsis (GO:0007129)3.07175972
95sister chromatid segregation (GO:0000819)3.06660085
96histone mRNA metabolic process (GO:0008334)3.06058579
97protein K6-linked ubiquitination (GO:0085020)3.05680076
98mitochondrial RNA metabolic process (GO:0000959)3.04620052
99regulation of RNA export from nucleus (GO:0046831)3.04612852
100resolution of meiotic recombination intermediates (GO:0000712)3.04596229
101histone exchange (GO:0043486)3.03934982
102regulation of double-strand break repair via homologous recombination (GO:0010569)3.03703835
103negative regulation of DNA recombination (GO:0045910)3.03457428
104negative regulation of chromosome segregation (GO:0051985)3.01306318
105regulation of chromosome segregation (GO:0051983)2.99651794
106negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98918849
107rRNA processing (GO:0006364)2.98558247
108maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.98444672
109pre-miRNA processing (GO:0031054)2.98313495
110chromatin assembly or disassembly (GO:0006333)2.96268510
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.96267245
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96267245
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96267245
114negative regulation of sister chromatid segregation (GO:0033046)2.96267245
115spindle checkpoint (GO:0031577)2.95225934
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94884570
117dosage compensation (GO:0007549)2.93982576
118establishment of integrated proviral latency (GO:0075713)2.92887768
119ribosomal large subunit biogenesis (GO:0042273)2.92593839
120mRNA transport (GO:0051028)2.92579013
121protein localization to chromosome (GO:0034502)2.92328905
122heterochromatin organization (GO:0070828)2.91585814
123kinetochore assembly (GO:0051382)2.90717506
124mitotic spindle checkpoint (GO:0071174)2.90610363
125mitotic spindle assembly checkpoint (GO:0007094)2.90465144
126rRNA metabolic process (GO:0016072)2.90385189
127maturation of 5.8S rRNA (GO:0000460)2.90051760
128spindle assembly checkpoint (GO:0071173)2.89947227
129histone H2A acetylation (GO:0043968)2.89926859
130regulation of translational termination (GO:0006449)2.89744169
131spliceosomal tri-snRNP complex assembly (GO:0000244)2.89403533
132RNA splicing, via transesterification reactions (GO:0000375)2.89252193
133response to pheromone (GO:0019236)2.88659470
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.88495667
135positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88326597
136postreplication repair (GO:0006301)2.87820882
137exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87697660
138RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.87660472
139mRNA splicing, via spliceosome (GO:0000398)2.87660472
140folic acid metabolic process (GO:0046655)2.87586364
141negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87094565
142water-soluble vitamin biosynthetic process (GO:0042364)2.85779967
143nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83636360
144negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83184359
145negative regulation of ligase activity (GO:0051352)2.83184359
146establishment of protein localization to mitochondrial membrane (GO:0090151)2.82241954
147regulation of meiosis I (GO:0060631)2.81450781
148female gonad development (GO:0008585)2.80708565
149termination of RNA polymerase III transcription (GO:0006386)2.79894730
150transcription elongation from RNA polymerase III promoter (GO:0006385)2.79894730
151lactate metabolic process (GO:0006089)2.78839681
152tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78286685
153RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78286685
154lysine metabolic process (GO:0006553)2.71989852
155lysine catabolic process (GO:0006554)2.71989852
156protein neddylation (GO:0045116)2.71261674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.96488328
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.30690428
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.10261559
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.76242113
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15406984
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.04531988
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97221692
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86962706
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64804074
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.59353566
11NELFA_20434984_ChIP-Seq_ESCs_Mouse2.58997663
12ZNF274_21170338_ChIP-Seq_K562_Hela2.50230230
13* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39479823
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39436587
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.39430681
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.38319319
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.37127949
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36635479
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35103432
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.33727699
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33271756
22* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33233279
23XRN2_22483619_ChIP-Seq_HELA_Human2.23885723
24EWS_26573619_Chip-Seq_HEK293_Human2.17820203
25AR_21909140_ChIP-Seq_LNCAP_Human2.17420852
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16256511
27VDR_22108803_ChIP-Seq_LS180_Human2.15846697
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.13556792
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.12860767
30POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09759318
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08665438
32E2F1_21310950_ChIP-Seq_MCF-7_Human2.05949566
33VDR_23849224_ChIP-Seq_CD4+_Human2.02781995
34MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00526229
35FUS_26573619_Chip-Seq_HEK293_Human1.99008291
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94479565
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92165706
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.91825733
39P300_19829295_ChIP-Seq_ESCs_Human1.88432583
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85317188
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.85244165
42IGF1R_20145208_ChIP-Seq_DFB_Human1.82106585
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81135818
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.80129717
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77342932
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.74131947
47FOXP3_21729870_ChIP-Seq_TREG_Human1.73122995
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69646852
49TTF2_22483619_ChIP-Seq_HELA_Human1.68980701
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68691340
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68632951
52GABP_19822575_ChIP-Seq_HepG2_Human1.67007413
53* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64845371
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64718498
55DCP1A_22483619_ChIP-Seq_HELA_Human1.63581508
56ELK1_19687146_ChIP-ChIP_HELA_Human1.62695236
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62148768
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.59533749
59MYC_18940864_ChIP-ChIP_HL60_Human1.59360217
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57147522
61CIITA_25753668_ChIP-Seq_RAJI_Human1.56709620
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55585988
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55105267
64TAF15_26573619_Chip-Seq_HEK293_Human1.52431572
65MYC_22102868_ChIP-Seq_BL_Human1.48546910
66KDM5A_27292631_Chip-Seq_BREAST_Human1.47462848
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.46935168
68* NANOG_16153702_ChIP-ChIP_HESCs_Human1.46633932
69* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.45248458
70* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44959576
71* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41512590
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.38666085
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.38666085
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.38666085
75* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38016558
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37227469
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.35160221
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.34405228
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.34337662
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33344275
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33303425
82* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31460838
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30928865
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29484990
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29060859
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28528556
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.28307045
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28191086
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26623216
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.26205370
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25736528
92GBX2_23144817_ChIP-Seq_PC3_Human1.25513343
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25187834
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24172045
95TP63_19390658_ChIP-ChIP_HaCaT_Human1.19596317
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19502854
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18834089
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18345639
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17075190
100TFEB_21752829_ChIP-Seq_HELA_Human1.16866464
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12821038
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11430701
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10846642
104PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10084775
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.09452162
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09083603
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08824480
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08703523
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08591829
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08090190
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.07953162
112ER_23166858_ChIP-Seq_MCF-7_Human1.07740531
113RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07426753
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06865760
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06817267
116DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06379279
117ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06331289
118TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06095961
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06053612
120NANOG_19829295_ChIP-Seq_ESCs_Human1.03664098
121SOX2_19829295_ChIP-Seq_ESCs_Human1.03664098
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03564323
123BCAT_22108803_ChIP-Seq_LS180_Human1.03211920
124MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02590418
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.01730943
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00447116
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00000116
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99767847
129* SRF_21415370_ChIP-Seq_HL-1_Mouse0.99763757
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99172335
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98587543
132ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98311552
133SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97415532
134* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96403744
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95750366
136CRX_20693478_ChIP-Seq_RETINA_Mouse0.95595328
137SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95296014
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.95138914
139FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95118504
140TCF4_22108803_ChIP-Seq_LS180_Human0.95103218
141HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95055229
142* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92735858
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91752268
144SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91489657
145CDX2_22108803_ChIP-Seq_LS180_Human0.91053187
146ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89780667
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89017674
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.88449941
149IRF1_19129219_ChIP-ChIP_H3396_Human0.88192643
150SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87945445
151BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87350362
152SUZ12_18555785_Chip-Seq_ESCs_Mouse0.87282650
153CBP_20019798_ChIP-Seq_JUKART_Human0.87245052
154OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86168597
155SOX2_18692474_ChIP-Seq_MESCs_Mouse0.86015450
156DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84979231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.96969845
2MP0010094_abnormal_chromosome_stability4.57034169
3MP0004957_abnormal_blastocyst_morpholog4.27927018
4MP0003111_abnormal_nucleus_morphology4.26215112
5MP0008057_abnormal_DNA_replication4.22535234
6MP0003077_abnormal_cell_cycle3.84647234
7MP0008058_abnormal_DNA_repair3.44271106
8MP0002254_reproductive_system_inflammat3.27557380
9MP0008007_abnormal_cellular_replicative2.77624630
10MP0001730_embryonic_growth_arrest2.74070031
11MP0008932_abnormal_embryonic_tissue2.72841744
12MP0002102_abnormal_ear_morphology2.67309778
13MP0008877_abnormal_DNA_methylation2.60243174
14MP0003123_paternal_imprinting2.57016035
15MP0000350_abnormal_cell_proliferation2.47358087
16MP0003806_abnormal_nucleotide_metabolis2.42750825
17MP0010307_abnormal_tumor_latency2.41543344
18MP0010352_gastrointestinal_tract_polyps2.31206660
19MP0003195_calcinosis2.20930623
20MP0003786_premature_aging2.08693957
21MP0006054_spinal_hemorrhage2.08655011
22MP0009697_abnormal_copulation2.04671616
23MP0001697_abnormal_embryo_size2.01738086
24MP0005380_embryogenesis_phenotype2.01457259
25MP0001672_abnormal_embryogenesis/_devel2.01457259
26MP0002938_white_spotting1.97262925
27MP0002084_abnormal_developmental_patter1.94802494
28MP0006072_abnormal_retinal_apoptosis1.91138912
29MP0002085_abnormal_embryonic_tissue1.89845150
30MP0004197_abnormal_fetal_growth/weight/1.84564601
31MP0003890_abnormal_embryonic-extraembry1.79297399
32MP0003984_embryonic_growth_retardation1.78887841
33MP0002837_dystrophic_cardiac_calcinosis1.78662340
34MP0002080_prenatal_lethality1.77804383
35MP0002088_abnormal_embryonic_growth/wei1.74874108
36MP0001293_anophthalmia1.70049034
37MP0002086_abnormal_extraembryonic_tissu1.69778972
38MP0002396_abnormal_hematopoietic_system1.65680393
39MP0002751_abnormal_autonomic_nervous1.63304484
40MP0000372_irregular_coat_pigmentation1.59156293
41MP0002653_abnormal_ependyma_morphology1.54626981
42MP0003121_genomic_imprinting1.54214414
43MP0002210_abnormal_sex_determination1.54114538
44MP0001529_abnormal_vocalization1.51760260
45MP0003718_maternal_effect1.50895008
46MP0005075_abnormal_melanosome_morpholog1.49128993
47MP0000537_abnormal_urethra_morphology1.48766780
48MP0003787_abnormal_imprinting1.48703157
49MP0000313_abnormal_cell_death1.43110706
50MP0009053_abnormal_anal_canal1.42467447
51MP0005076_abnormal_cell_differentiation1.41362233
52MP0003567_abnormal_fetal_cardiomyocyte1.41006361
53MP0006035_abnormal_mitochondrial_morpho1.36252890
54MP0010030_abnormal_orbit_morphology1.36216496
55MP0001145_abnormal_male_reproductive1.32969202
56MP0003119_abnormal_digestive_system1.30128299
57MP0001984_abnormal_olfaction1.25509183
58MP0002019_abnormal_tumor_incidence1.25273798
59MP0001485_abnormal_pinna_reflex1.25030857
60MP0000647_abnormal_sebaceous_gland1.24183018
61MP0005084_abnormal_gallbladder_morpholo1.24162455
62MP0001177_atelectasis1.18863928
63MP0000490_abnormal_crypts_of1.18562470
64MP0002736_abnormal_nociception_after1.17625716
65MP0001929_abnormal_gametogenesis1.16663656
66MP0003705_abnormal_hypodermis_morpholog1.16086361
67MP0000653_abnormal_sex_gland1.12945694
68MP0004808_abnormal_hematopoietic_stem1.12378495
69MP0002090_abnormal_vision1.10921588
70MP0009672_abnormal_birth_weight1.10393612
71MP0005253_abnormal_eye_physiology1.10327578
72MP0004133_heterotaxia1.09270090
73MP0001915_intracranial_hemorrhage1.08534673
74MP0002111_abnormal_tail_morphology1.05230171
75MP0003937_abnormal_limbs/digits/tail_de1.05025353
76MP0000427_abnormal_hair_cycle1.04267689
77MP0004147_increased_porphyrin_level1.04159204
78MP0003122_maternal_imprinting1.03814139
79MP0005395_other_phenotype1.02886834
80MP0002160_abnormal_reproductive_system0.99482974
81MP0006036_abnormal_mitochondrial_physio0.99295021
82MP0003941_abnormal_skin_development0.98523586
83MP0009703_decreased_birth_body0.98376837
84MP0005551_abnormal_eye_electrophysiolog0.98038008
85MP0001324_abnormal_eye_pigmentation0.96705041
86MP0008789_abnormal_olfactory_epithelium0.96342735
87MP0002092_abnormal_eye_morphology0.94299111
88MP0009333_abnormal_splenocyte_physiolog0.94015952
89MP0004215_abnormal_myocardial_fiber0.92670663
90MP0003315_abnormal_perineum_morphology0.92259768
91MP0005384_cellular_phenotype0.88249159
92MP0000428_abnormal_craniofacial_morphol0.87133993
93MP0000703_abnormal_thymus_morphology0.85895582
94MP0005621_abnormal_cell_physiology0.84972402
95MP0003861_abnormal_nervous_system0.84530504
96MP0001286_abnormal_eye_development0.84338360
97MP0001119_abnormal_female_reproductive0.83676305
98MP0000358_abnormal_cell_content/0.83347086
99MP0003221_abnormal_cardiomyocyte_apopto0.81685997
100MP0003943_abnormal_hepatobiliary_system0.79279868
101MP0002163_abnormal_gland_morphology0.79239128
102MP0001986_abnormal_taste_sensitivity0.79131723
103MP0000432_abnormal_head_morphology0.77526424
104MP0005389_reproductive_system_phenotype0.76733135
105MP0002697_abnormal_eye_size0.76474218
106MP0003136_yellow_coat_color0.74235467
107MP0001188_hyperpigmentation0.74229805
108MP0000383_abnormal_hair_follicle0.71462144
109MP0010678_abnormal_skin_adnexa0.71299240
110MP0003566_abnormal_cell_adhesion0.70368804
111MP0008995_early_reproductive_senescence0.70272088
112MP0005391_vision/eye_phenotype0.69867962
113MP0008872_abnormal_physiological_respon0.69449848
114MP0006292_abnormal_olfactory_placode0.69246925
115MP0005410_abnormal_fertilization0.67776564
116MP0004233_abnormal_muscle_weight0.67363639
117MP0002277_abnormal_respiratory_mucosa0.65323762
118MP0005248_abnormal_Harderian_gland0.64778845
119MP0000631_abnormal_neuroendocrine_gland0.64761617
120MP0003698_abnormal_male_reproductive0.64628724
121MP0002722_abnormal_immune_system0.64420270
122MP0005023_abnormal_wound_healing0.63995519
123MP0003186_abnormal_redox_activity0.63563904
124MP0010234_abnormal_vibrissa_follicle0.63365893
125MP0003755_abnormal_palate_morphology0.62711082
126MP0003935_abnormal_craniofacial_develop0.62267115
127MP0003115_abnormal_respiratory_system0.61615498
128MP0000689_abnormal_spleen_morphology0.60749329
129MP0002398_abnormal_bone_marrow0.59501308
130MP0002161_abnormal_fertility/fecundity0.59446436
131MP0001849_ear_inflammation0.58582594
132MP0002233_abnormal_nose_morphology0.56631540
133MP0008770_decreased_survivor_rate0.55692825
134MP0001661_extended_life_span0.55676491
135MP0005394_taste/olfaction_phenotype0.54906158
136MP0005499_abnormal_olfactory_system0.54906158
137MP0000371_diluted_coat_color0.54267351
138MP0005367_renal/urinary_system_phenotyp0.53981983
139MP0000516_abnormal_urinary_system0.53981983
140MP0001727_abnormal_embryo_implantation0.53818967
141MP0002114_abnormal_axial_skeleton0.53744554
142MP0002075_abnormal_coat/hair_pigmentati0.53144786

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.11894936
2Medulloblastoma (HP:0002885)4.33981856
3Ependymoma (HP:0002888)4.23188661
4Degeneration of anterior horn cells (HP:0002398)3.81601378
5Abnormality of the anterior horn cell (HP:0006802)3.81601378
6Selective tooth agenesis (HP:0001592)3.76440167
7Abnormality of the labia minora (HP:0012880)3.59104633
8Colon cancer (HP:0003003)3.57847636
9Breast hypoplasia (HP:0003187)3.55988752
10Patellar aplasia (HP:0006443)3.38432328
11Neoplasm of the oral cavity (HP:0100649)3.22814989
12Intestinal atresia (HP:0011100)3.12559311
13Aplasia/Hypoplasia of the patella (HP:0006498)3.12210027
14Astrocytoma (HP:0009592)3.05188639
15Abnormality of the astrocytes (HP:0100707)3.05188639
16Rhabdomyosarcoma (HP:0002859)3.04417963
17Supernumerary spleens (HP:0009799)2.99629056
18Oral leukoplakia (HP:0002745)2.98650460
19Chromsome breakage (HP:0040012)2.97306572
20Glioma (HP:0009733)2.93218755
21Carpal bone hypoplasia (HP:0001498)2.93130192
22Agnosia (HP:0010524)2.88406036
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84272687
24Cerebral hypomyelination (HP:0006808)2.82857459
25Pancreatic cysts (HP:0001737)2.74281725
26Absent radius (HP:0003974)2.72389978
27Abnormality of methionine metabolism (HP:0010901)2.71800640
28Methylmalonic acidemia (HP:0002912)2.66217565
29Abnormality of chromosome stability (HP:0003220)2.62019258
30Abnormality of the duodenum (HP:0002246)2.61641601
31Abnormality of aspartate family amino acid metabolism (HP:0010899)2.57361859
32Volvulus (HP:0002580)2.56659165
33Progressive inability to walk (HP:0002505)2.54924259
34Proximal placement of thumb (HP:0009623)2.53152818
35Pancreatic islet-cell hyperplasia (HP:0004510)2.52665321
36Aplasia involving forearm bones (HP:0009822)2.51383296
37Absent forearm bone (HP:0003953)2.51383296
38Impulsivity (HP:0100710)2.50924625
39Hyperglycinemia (HP:0002154)2.45214759
40Embryonal renal neoplasm (HP:0011794)2.44748140
41Deviation of the thumb (HP:0009603)2.44722281
42Pancreatic fibrosis (HP:0100732)2.44177225
43Neoplasm of the pancreas (HP:0002894)2.43680162
44Reticulocytopenia (HP:0001896)2.42708383
45Basal cell carcinoma (HP:0002671)2.42492541
46Nephroblastoma (Wilms tumor) (HP:0002667)2.41398559
47Abnormality of the ileum (HP:0001549)2.39686517
48Neoplasm of striated muscle (HP:0009728)2.38327797
49Rough bone trabeculation (HP:0100670)2.37954007
50Pelvic girdle muscle weakness (HP:0003749)2.37784101
51Meckel diverticulum (HP:0002245)2.35090523
52Atrophy/Degeneration involving motor neurons (HP:0007373)2.34515503
53Abnormality of abdominal situs (HP:0011620)2.33678916
54Abdominal situs inversus (HP:0003363)2.33678916
55Atresia of the external auditory canal (HP:0000413)2.33285999
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.31961627
57Neoplasm of the adrenal gland (HP:0100631)2.29563615
58Abnormality of serum amino acid levels (HP:0003112)2.28916906
59True hermaphroditism (HP:0010459)2.27784467
60Neoplasm of the adrenal cortex (HP:0100641)2.25177186
61Missing ribs (HP:0000921)2.24352962
62Hyperglycinuria (HP:0003108)2.23030313
63Aplasia/hypoplasia of the humerus (HP:0006507)2.20201448
64Septo-optic dysplasia (HP:0100842)2.19413483
65Abnormality of serine family amino acid metabolism (HP:0010894)2.19286995
66Abnormality of glycine metabolism (HP:0010895)2.19286995
67Premature graying of hair (HP:0002216)2.17841414
68Multiple enchondromatosis (HP:0005701)2.16525803
69Abnormal number of incisors (HP:0011064)2.14824221
70Increased hepatocellular lipid droplets (HP:0006565)2.14685800
71Increased nuchal translucency (HP:0010880)2.14357235
72Abnormality of the preputium (HP:0100587)2.13842948
73Trismus (HP:0000211)2.13619666
74Dandy-Walker malformation (HP:0001305)2.12959811
75Clubbing of toes (HP:0100760)2.12644021
7611 pairs of ribs (HP:0000878)2.11448683
77Biliary tract neoplasm (HP:0100574)2.10826814
78Pendular nystagmus (HP:0012043)2.10789933
79Rectovaginal fistula (HP:0000143)2.10753860
80Rectal fistula (HP:0100590)2.10753860
81Sloping forehead (HP:0000340)2.10096783
82Cutaneous melanoma (HP:0012056)2.09921425
83Bifid tongue (HP:0010297)2.09887883
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.09367739
85Abolished electroretinogram (ERG) (HP:0000550)2.08274862
86Shoulder girdle muscle weakness (HP:0003547)2.07277107
87Cortical dysplasia (HP:0002539)2.05463355
88Methylmalonic aciduria (HP:0012120)2.03867932
89Aplasia/Hypoplasia of the sternum (HP:0006714)2.03667480
90Absent thumb (HP:0009777)2.02821812
91Spastic diplegia (HP:0001264)2.02219708
92Hypoplastic pelvis (HP:0008839)2.01484411
93Hyperinsulinemic hypoglycemia (HP:0000825)2.01120468
94Facial hemangioma (HP:0000329)2.00913922
95Squamous cell carcinoma (HP:0002860)2.00262758
96Myelodysplasia (HP:0002863)2.00032730
97Triphalangeal thumb (HP:0001199)1.99502468
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98580966
99Abnormality of alanine metabolism (HP:0010916)1.98580966
100Hyperalaninemia (HP:0003348)1.98580966
101Abnormal biliary tract physiology (HP:0012439)1.97530178
102Bile duct proliferation (HP:0001408)1.97530178
103Type I transferrin isoform profile (HP:0003642)1.97196546
104Abnormal protein N-linked glycosylation (HP:0012347)1.96411707
105Abnormal protein glycosylation (HP:0012346)1.96411707
106Abnormal glycosylation (HP:0012345)1.96411707
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96411707
108Gastrointestinal carcinoma (HP:0002672)1.95196224
109Malignant gastrointestinal tract tumors (HP:0006749)1.95196224
110Amaurosis fugax (HP:0100576)1.94827039
111Acute encephalopathy (HP:0006846)1.94769516
112Lipid accumulation in hepatocytes (HP:0006561)1.94672790
113Nephronophthisis (HP:0000090)1.94175675
114Gastrointestinal atresia (HP:0002589)1.93975312
115Hypoglycemic seizures (HP:0002173)1.93598626
116Tracheoesophageal fistula (HP:0002575)1.93251381
117Cellular immunodeficiency (HP:0005374)1.93242772
118Horseshoe kidney (HP:0000085)1.92703087
119Short humerus (HP:0005792)1.91753982
120Ectopic kidney (HP:0000086)1.89793020
121Bone marrow hypocellularity (HP:0005528)1.88978627
122Spinal muscular atrophy (HP:0007269)1.88622958
123Molar tooth sign on MRI (HP:0002419)1.88397669
124Abnormality of midbrain morphology (HP:0002418)1.88397669
125Abnormal lung lobation (HP:0002101)1.88098114
126Abnormality of the lower motor neuron (HP:0002366)1.87497231
127Acute necrotizing encephalopathy (HP:0006965)1.87407983
128Breast carcinoma (HP:0003002)1.86754476
129Posterior subcapsular cataract (HP:0007787)1.86020147
130Aqueductal stenosis (HP:0002410)1.85576561
131Aplasia/Hypoplasia of the spleen (HP:0010451)1.83804007
132Asplenia (HP:0001746)1.83602903
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83432397
134Pseudobulbar signs (HP:0002200)1.83333791
135Abnormality of cells of the erythroid lineage (HP:0012130)1.83303283
136Abnormality of pyrimidine metabolism (HP:0004353)1.83048920
137Neoplasm of the colon (HP:0100273)1.82782015
138Duodenal stenosis (HP:0100867)1.81786945
139Small intestinal stenosis (HP:0012848)1.81786945
140Abnormality of the hip-girdle musculature (HP:0001445)1.81698404
141Abnormality of the musculature of the pelvis (HP:0001469)1.81698404
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81669011
143Tongue fasciculations (HP:0001308)1.81617302
144Short 4th metacarpal (HP:0010044)1.81599290
145Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81599290
146Freckling (HP:0001480)1.81563690
147Abnormality of the pancreatic islet cells (HP:0006476)1.81489853
148Abnormality of endocrine pancreas physiology (HP:0012093)1.81489853
149Increased CSF lactate (HP:0002490)1.81124255
150Aplastic anemia (HP:0001915)1.80467703
151Inability to walk (HP:0002540)1.80141126
152Abnormality of the pons (HP:0007361)1.80111000
153Stenosis of the external auditory canal (HP:0000402)1.79879327
154Cafe-au-lait spot (HP:0000957)1.79130055
155Overlapping toe (HP:0001845)1.78847268
156Abnormality of the fetal cardiovascular system (HP:0010948)1.78664590
157Abnormal umbilical cord blood vessels (HP:0011403)1.78664590
158Single umbilical artery (HP:0001195)1.78664590
159Esophageal atresia (HP:0002032)1.77715120
160Facial cleft (HP:0002006)1.77430847
161Metaphyseal cupping (HP:0003021)1.76880985
162Medial flaring of the eyebrow (HP:0010747)1.76775304
163Slender long bone (HP:0003100)1.76701241
164Gonadotropin excess (HP:0000837)1.74072341
165Small hand (HP:0200055)1.71312562
166Anencephaly (HP:0002323)1.70838177
167Genital tract atresia (HP:0001827)1.70624462
168Abnormal hair whorl (HP:0010721)1.70268729
169Progressive macrocephaly (HP:0004481)1.69740532
170Ovarian neoplasm (HP:0100615)1.69350259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.43818134
2WEE13.88714508
3TRIM283.66849356
4BUB13.22881120
5WNK33.04463874
6MST42.96804462
7TSSK62.86752082
8NEK22.82015418
9EIF2AK12.72079005
10SRPK12.63033835
11TNIK2.62773872
12PLK42.60414349
13CDK122.47939390
14PASK2.47335384
15NEK12.44419687
16FRK2.28232077
17NUAK12.27137349
18MAP4K22.17507517
19BMPR1B2.14385566
20ACVR1B2.13352392
21TTK2.11550664
22MKNK12.10677358
23PLK11.98540708
24EIF2AK31.95039471
25VRK21.90013347
26EPHA21.88754884
27TAF11.88389357
28TESK21.87112055
29DYRK31.86187527
30RPS6KB21.81836717
31ATR1.81398089
32PLK31.77035280
33CDK71.76219147
34BCR1.64116523
35SCYL21.61843936
36BRSK21.48911028
37PKN21.46002867
38BRD41.45863816
39CHEK11.43626610
40AURKB1.39711011
41MKNK21.38774683
42FLT31.37029471
43MAP3K81.35125230
44CHEK21.34266045
45EEF2K1.32915375
46MAP3K101.30482507
47TLK11.28862944
48CDK41.19769179
49STK101.18369218
50TGFBR11.16188554
51LATS11.14211838
52GRK11.11885640
53STK41.09929623
54AURKA1.09908270
55NLK1.09469892
56VRK11.06490870
57ALK1.06441573
58STK391.01175793
59OXSR11.00455350
60CDK20.99878575
61PNCK0.97871536
62CSNK1G20.96987680
63ATM0.96713748
64ZAK0.95838364
65STK240.95425623
66RPS6KA40.94032699
67LATS20.92196107
68PIM10.91722493
69INSRR0.90424704
70ERBB30.89001325
71SIK30.85975423
72PAK40.85086934
73TESK10.83686668
74MAP3K120.81599270
75CDK60.78806604
76MTOR0.74329757
77PAK30.74055732
78ADRBK20.73434375
79CDK10.72695304
80STK30.71638757
81CSNK2A20.69700970
82WNK40.68420209
83FGFR10.68139032
84KSR10.68010573
85BRSK10.66916781
86MELK0.66208117
87MAP3K40.65676194
88PDK30.65132019
89PDK40.65132019
90STK160.64194941
91LIMK10.61430345
92DYRK20.60845331
93NME20.59302003
94PAK10.58222584
95BRAF0.57626538
96CASK0.57598638
97PRKCI0.56234365
98CSNK1D0.55577617
99CDK80.54016388
100CSNK1G30.53297423
101CSNK2A10.53292753
102CSNK1E0.50349062
103MAPK130.49190231
104MET0.49042320
105RAF10.48636504
106LRRK20.48425597
107PRKCE0.47599147
108PBK0.47498513
109EIF2AK20.45851768
110CCNB10.43335081
111STK38L0.43211254
112TIE10.41926143
113RPS6KA50.41782844
114PRKDC0.41438872
115ICK0.40361757
116AKT30.39273926
117CLK10.38810994
118ARAF0.37790817
119TYRO30.36912019
120CSNK1A1L0.34853566
121PDK20.34184559
122NME10.34077604
123PLK20.34048305
124PRKCG0.33199603
125CSNK1G10.33098945
126AKT20.32300153
127YES10.32260914
128PAK20.32225587
129PINK10.31703418
130FER0.31697224
131DYRK1B0.31555244
132MAPK140.31175014
133FGFR20.31125483
134ERBB40.29307300
135PIM20.28386243
136NEK90.27771595
137BCKDK0.26468205
138CDK30.24712369
139CSNK1A10.23426081
140PRKD30.20026035
141TXK0.17191031

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.48562845
2Mismatch repair_Homo sapiens_hsa034304.21904332
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.01173429
4Protein export_Homo sapiens_hsa030603.57891718
5RNA transport_Homo sapiens_hsa030133.48281238
6Spliceosome_Homo sapiens_hsa030403.40362824
7One carbon pool by folate_Homo sapiens_hsa006703.21567342
8RNA polymerase_Homo sapiens_hsa030202.95333192
9Homologous recombination_Homo sapiens_hsa034402.90255616
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.88814145
11Cell cycle_Homo sapiens_hsa041102.83648842
12Nucleotide excision repair_Homo sapiens_hsa034202.72822824
13Proteasome_Homo sapiens_hsa030502.70820991
14Base excision repair_Homo sapiens_hsa034102.54403205
15Propanoate metabolism_Homo sapiens_hsa006402.23508434
16Steroid biosynthesis_Homo sapiens_hsa001002.16906214
17Ribosome_Homo sapiens_hsa030102.14377507
18Non-homologous end-joining_Homo sapiens_hsa034502.11615167
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11206126
20Fanconi anemia pathway_Homo sapiens_hsa034602.11183390
21mRNA surveillance pathway_Homo sapiens_hsa030152.08459397
22Pyrimidine metabolism_Homo sapiens_hsa002402.08457102
23* Basal transcription factors_Homo sapiens_hsa030221.91994255
24RNA degradation_Homo sapiens_hsa030181.84916003
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80258312
26p53 signaling pathway_Homo sapiens_hsa041151.75516250
27Fatty acid elongation_Homo sapiens_hsa000621.48033628
28Systemic lupus erythematosus_Homo sapiens_hsa053221.45516363
29Selenocompound metabolism_Homo sapiens_hsa004501.27643912
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.26767430
31* Epstein-Barr virus infection_Homo sapiens_hsa051691.22264508
32Biosynthesis of amino acids_Homo sapiens_hsa012301.21745351
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.17894153
34* Viral carcinogenesis_Homo sapiens_hsa052031.15314182
35Phototransduction_Homo sapiens_hsa047441.13652857
36Oxidative phosphorylation_Homo sapiens_hsa001901.12247989
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11092598
38Purine metabolism_Homo sapiens_hsa002301.09974139
39Butanoate metabolism_Homo sapiens_hsa006501.07182047
40Sulfur metabolism_Homo sapiens_hsa009201.05304243
41Oocyte meiosis_Homo sapiens_hsa041141.05147691
42Parkinsons disease_Homo sapiens_hsa050121.03836037
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.99863531
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96085746
45Pentose phosphate pathway_Homo sapiens_hsa000300.92281125
46Caffeine metabolism_Homo sapiens_hsa002320.91890581
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89522454
48Vitamin B6 metabolism_Homo sapiens_hsa007500.88218609
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87682703
50MicroRNAs in cancer_Homo sapiens_hsa052060.87539894
51Tryptophan metabolism_Homo sapiens_hsa003800.87462992
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87188953
53Folate biosynthesis_Homo sapiens_hsa007900.86413206
54Herpes simplex infection_Homo sapiens_hsa051680.84769364
55Antigen processing and presentation_Homo sapiens_hsa046120.84230785
56Huntingtons disease_Homo sapiens_hsa050160.78172538
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.78102146
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77163582
59Peroxisome_Homo sapiens_hsa041460.74759593
60Fatty acid degradation_Homo sapiens_hsa000710.73647061
61Fatty acid metabolism_Homo sapiens_hsa012120.73430573
62HTLV-I infection_Homo sapiens_hsa051660.72793249
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.72110067
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69413004
65Colorectal cancer_Homo sapiens_hsa052100.68268906
66Thyroid cancer_Homo sapiens_hsa052160.67558587
67Hippo signaling pathway_Homo sapiens_hsa043900.65644900
68Small cell lung cancer_Homo sapiens_hsa052220.65127808
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65087081
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63833048
71Legionellosis_Homo sapiens_hsa051340.63202921
72Carbon metabolism_Homo sapiens_hsa012000.62302234
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61507704
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61477441
75Basal cell carcinoma_Homo sapiens_hsa052170.61193341
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61096963
77beta-Alanine metabolism_Homo sapiens_hsa004100.60829265
78Metabolic pathways_Homo sapiens_hsa011000.60820599
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59605486
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.59145111
81Alcoholism_Homo sapiens_hsa050340.58474660
82Nitrogen metabolism_Homo sapiens_hsa009100.58207196
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56869881
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55341490
85TGF-beta signaling pathway_Homo sapiens_hsa043500.55230947
86Apoptosis_Homo sapiens_hsa042100.54752550
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54205626
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53344179
89Regulation of autophagy_Homo sapiens_hsa041400.50871715
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50583634
91mTOR signaling pathway_Homo sapiens_hsa041500.48829520
92Chronic myeloid leukemia_Homo sapiens_hsa052200.48256730
93Lysine degradation_Homo sapiens_hsa003100.48190073
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47927855
95Vitamin digestion and absorption_Homo sapiens_hsa049770.47898479
96Notch signaling pathway_Homo sapiens_hsa043300.47451685
97Ether lipid metabolism_Homo sapiens_hsa005650.44398521
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44327118
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43790803
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42690015
101Wnt signaling pathway_Homo sapiens_hsa043100.41897040
102Glutathione metabolism_Homo sapiens_hsa004800.41415180
103Bladder cancer_Homo sapiens_hsa052190.41073277
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.39539119
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38589639
106Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37382759
107Alzheimers disease_Homo sapiens_hsa050100.36643325
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34973567
109Prostate cancer_Homo sapiens_hsa052150.34902261
110Sphingolipid metabolism_Homo sapiens_hsa006000.34849508
111N-Glycan biosynthesis_Homo sapiens_hsa005100.31860141
112Endometrial cancer_Homo sapiens_hsa052130.31609322
113Hedgehog signaling pathway_Homo sapiens_hsa043400.31199002
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30053858
115Hepatitis B_Homo sapiens_hsa051610.29128358
116Fructose and mannose metabolism_Homo sapiens_hsa000510.28299758
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.27359213
118Adherens junction_Homo sapiens_hsa045200.27253918
119Pathways in cancer_Homo sapiens_hsa052000.26931518
120Non-small cell lung cancer_Homo sapiens_hsa052230.26115051
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25584261
122Retinol metabolism_Homo sapiens_hsa008300.25450268
123HIF-1 signaling pathway_Homo sapiens_hsa040660.25287484
124Taste transduction_Homo sapiens_hsa047420.24618369
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22784148
126Viral myocarditis_Homo sapiens_hsa054160.22545209
127Linoleic acid metabolism_Homo sapiens_hsa005910.20989746
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20151097
129FoxO signaling pathway_Homo sapiens_hsa040680.19220001
130Sulfur relay system_Homo sapiens_hsa041220.19140741
131Shigellosis_Homo sapiens_hsa051310.17899465
132Pyruvate metabolism_Homo sapiens_hsa006200.17508508
133Arginine and proline metabolism_Homo sapiens_hsa003300.17194218
134Measles_Homo sapiens_hsa051620.17050509
135Melanoma_Homo sapiens_hsa052180.16610417
136Pancreatic cancer_Homo sapiens_hsa052120.16574351
137Nicotine addiction_Homo sapiens_hsa050330.16266493
138Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15806862
139Galactose metabolism_Homo sapiens_hsa000520.15381559
140Acute myeloid leukemia_Homo sapiens_hsa052210.15091974
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15057211
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14396930
143Renal cell carcinoma_Homo sapiens_hsa052110.11727350
144Tight junction_Homo sapiens_hsa045300.11208291
145Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09788997

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