GTF2E2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.10757704
2regulation of retinoic acid receptor signaling pathway (GO:0048385)4.39253845
3DNA strand elongation involved in DNA replication (GO:0006271)4.37998233
4DNA strand elongation (GO:0022616)4.15592923
5mitotic metaphase plate congression (GO:0007080)4.13503108
6telomere maintenance via semi-conservative replication (GO:0032201)4.11558785
7maturation of SSU-rRNA (GO:0030490)4.10065806
8DNA replication initiation (GO:0006270)4.06255676
9DNA replication checkpoint (GO:0000076)3.97684250
10chromatin remodeling at centromere (GO:0031055)3.97012670
11CENP-A containing nucleosome assembly (GO:0034080)3.92509041
12formation of translation preinitiation complex (GO:0001731)3.89280555
13nucleobase biosynthetic process (GO:0046112)3.82884639
14telomere maintenance via recombination (GO:0000722)3.82739926
15DNA replication-dependent nucleosome assembly (GO:0006335)3.80253891
16DNA replication-dependent nucleosome organization (GO:0034723)3.80253891
17metaphase plate congression (GO:0051310)3.75784031
18purine nucleobase biosynthetic process (GO:0009113)3.75692817
19ribosomal small subunit assembly (GO:0000028)3.70977422
20DNA unwinding involved in DNA replication (GO:0006268)3.69161407
21regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.63480886
22mitotic recombination (GO:0006312)3.62875665
23DNA replication-independent nucleosome assembly (GO:0006336)3.62687426
24DNA replication-independent nucleosome organization (GO:0034724)3.62687426
25protein localization to kinetochore (GO:0034501)3.62512834
26proteasome assembly (GO:0043248)3.62235815
27nuclear pore organization (GO:0006999)3.57124949
28mitotic nuclear envelope disassembly (GO:0007077)3.56230492
29kinetochore organization (GO:0051383)3.54660528
30histone exchange (GO:0043486)3.52459720
31base-excision repair, AP site formation (GO:0006285)3.46913312
32cullin deneddylation (GO:0010388)3.45944705
33attachment of spindle microtubules to kinetochore (GO:0008608)3.43904852
34ribosome biogenesis (GO:0042254)3.42271760
35establishment of chromosome localization (GO:0051303)3.41745490
36ribosomal large subunit biogenesis (GO:0042273)3.39505628
37protein deneddylation (GO:0000338)3.35961204
38telomere maintenance via telomere lengthening (GO:0010833)3.34770385
39DNA deamination (GO:0045006)3.34608282
40ribosome assembly (GO:0042255)3.34185651
41nucleotide-excision repair, DNA gap filling (GO:0006297)3.33779748
42ribonucleoprotein complex biogenesis (GO:0022613)3.32380641
43protein localization to chromosome, centromeric region (GO:0071459)3.32176353
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31746691
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30622669
46regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29490447
47spliceosomal snRNP assembly (GO:0000387)3.28901874
48nuclear envelope disassembly (GO:0051081)3.28823292
49membrane disassembly (GO:0030397)3.28823292
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28349785
51ribonucleoprotein complex disassembly (GO:0032988)3.25678696
52nuclear pore complex assembly (GO:0051292)3.25109016
53pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.24909461
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23838984
55kinetochore assembly (GO:0051382)3.23821233
56regulation of translational termination (GO:0006449)3.22779978
57meiotic chromosome segregation (GO:0045132)3.19508207
58pore complex assembly (GO:0046931)3.16037175
59folic acid-containing compound biosynthetic process (GO:0009396)3.15608341
60ribosomal small subunit biogenesis (GO:0042274)3.15263419
61translational termination (GO:0006415)3.15044771
62viral mRNA export from host cell nucleus (GO:0046784)3.14481980
63positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.14461840
64regulation of mitochondrial translation (GO:0070129)3.13892112
65viral transcription (GO:0019083)3.11814466
66somatic diversification of immune receptors via somatic mutation (GO:0002566)3.10977469
67somatic hypermutation of immunoglobulin genes (GO:0016446)3.10977469
68protein K6-linked ubiquitination (GO:0085020)3.10759257
69rRNA processing (GO:0006364)3.09875761
70transcription-coupled nucleotide-excision repair (GO:0006283)3.09657307
71IMP biosynthetic process (GO:0006188)3.08222300
72establishment of integrated proviral latency (GO:0075713)3.05638692
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04004893
74negative regulation of ligase activity (GO:0051352)3.04004893
75regulation of spindle organization (GO:0090224)3.03812844
76establishment of protein localization to mitochondrial membrane (GO:0090151)3.03726476
77negative regulation of chromosome segregation (GO:0051985)3.03722461
78translational initiation (GO:0006413)3.03504676
79negative regulation of mitotic sister chromatid separation (GO:2000816)3.02457472
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.02457472
81negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.02457472
82negative regulation of sister chromatid segregation (GO:0033046)3.02457472
83establishment of viral latency (GO:0019043)3.00769645
84mitotic sister chromatid cohesion (GO:0007064)2.99530054
85rRNA metabolic process (GO:0016072)2.99404342
86regulation of double-strand break repair via homologous recombination (GO:0010569)2.99183067
87mitotic sister chromatid segregation (GO:0000070)2.98804317
88regulation of centrosome cycle (GO:0046605)2.98306827
89spindle checkpoint (GO:0031577)2.98024516
90mitotic chromosome condensation (GO:0007076)2.97597823
91synapsis (GO:0007129)2.97257480
92cell cycle G1/S phase transition (GO:0044843)2.95739725
93G1/S transition of mitotic cell cycle (GO:0000082)2.95739725
94mitotic spindle assembly checkpoint (GO:0007094)2.94260922
95negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.93697327
96spindle assembly checkpoint (GO:0071173)2.93308412
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93306644
98rRNA modification (GO:0000154)2.93210292
99SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92889061
100mitotic spindle checkpoint (GO:0071174)2.92354061
101sister chromatid segregation (GO:0000819)2.92307503
102translational elongation (GO:0006414)2.91781339
103regulation of centriole replication (GO:0046599)2.90822189
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90334886
105regulation of chromosome segregation (GO:0051983)2.90314645
106regulation of mitotic metaphase/anaphase transition (GO:0030071)2.90280328
107intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87496641
108signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87496641
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87458650
110protein localization to chromosome (GO:0034502)2.86981662
111cotranslational protein targeting to membrane (GO:0006613)2.86382071
112signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86272723
113signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86272723
114signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86272723
115organelle disassembly (GO:1903008)2.84118616
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.83787878
117protein targeting to ER (GO:0045047)2.83523504
118deoxyribonucleotide biosynthetic process (GO:0009263)2.82469404
119translation (GO:0006412)2.79463391
120pseudouridine synthesis (GO:0001522)2.77454699
121pteridine-containing compound biosynthetic process (GO:0042559)2.73929353
1222-deoxyribonucleotide biosynthetic process (GO:0009265)2.73529370
123deoxyribose phosphate biosynthetic process (GO:0046385)2.73529370
124establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73106853
125deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.70135462
126regulation of meiosis I (GO:0060631)2.68770751
127DNA damage response, detection of DNA damage (GO:0042769)2.68482130
128protein localization to endoplasmic reticulum (GO:0070972)2.67512603
129histone H2B ubiquitination (GO:0033523)2.66742354
130somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.66523200
131isotype switching (GO:0045190)2.66523200
132somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.66523200
133termination of RNA polymerase I transcription (GO:0006363)2.64175831
134chromosome segregation (GO:0007059)2.63933900
135nucleobase-containing small molecule interconversion (GO:0015949)2.61811854
136pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.60752320
137regulation of helicase activity (GO:0051095)2.60312629
138DNA catabolic process, exonucleolytic (GO:0000738)2.56772027
139regulation of DNA endoreduplication (GO:0032875)2.55959807
140cell fate commitment involved in formation of primary germ layer (GO:0060795)2.51607369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.80836061
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.34106827
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.63583377
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.60389609
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58662208
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.42666998
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.25356441
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.23592832
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.18422819
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.17864455
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.96431196
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93800412
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.91922384
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89174940
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83913596
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.82647351
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56193247
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54767671
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.50855139
20VDR_23849224_ChIP-Seq_CD4+_Human2.39285482
21XRN2_22483619_ChIP-Seq_HELA_Human2.37070430
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18404413
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.18320996
24DCP1A_22483619_ChIP-Seq_HELA_Human2.14475634
25AR_21909140_ChIP-Seq_LNCAP_Human2.08720024
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05320661
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04854861
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03959431
29FOXP3_21729870_ChIP-Seq_TREG_Human2.02118104
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98812747
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96034356
32GABP_19822575_ChIP-Seq_HepG2_Human1.92596391
33ELK1_19687146_ChIP-ChIP_HELA_Human1.92043199
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.91696499
35TTF2_22483619_ChIP-Seq_HELA_Human1.91692077
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90675474
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88351534
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86158178
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.86075180
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80575621
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73086138
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69220471
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64819197
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63169076
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62358640
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.62181785
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60858115
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60817703
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.59946750
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53330527
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.52066500
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50408236
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.48048680
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45434355
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42761578
56KDM5A_27292631_Chip-Seq_BREAST_Human1.40384879
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37550448
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34326375
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33752226
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31362957
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30080529
62CIITA_25753668_ChIP-Seq_RAJI_Human1.28809202
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26079919
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25437809
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23806804
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21957117
67ZNF274_21170338_ChIP-Seq_K562_Hela1.20599587
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20254561
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19829361
70TFEB_21752829_ChIP-Seq_HELA_Human1.19573891
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.19169234
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18226662
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18058543
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17717329
75* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15064154
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13583721
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12764088
78* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12487375
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09056365
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08788080
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.07962163
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07450054
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06704999
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04092568
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00704324
86ZNF263_19887448_ChIP-Seq_K562_Human0.98789496
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98546928
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96842344
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.96840145
90MYC_18940864_ChIP-ChIP_HL60_Human0.96496133
91ELF5_23300383_ChIP-Seq_T47D_Human0.96014357
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95622719
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95434606
94NOTCH1_21737748_ChIP-Seq_TLL_Human0.94661641
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93945562
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91892072
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91046041
98MYC_22102868_ChIP-Seq_BL_Human0.90556874
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.89729744
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89362186
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89362186
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89362186
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.89338862
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83398317
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82782334
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82568586
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.82432020
108* SPI1_23547873_ChIP-Seq_NB4_Human0.82247913
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81618775
110* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80359486
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80225392
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79388716
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.75650963
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73342195
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.71853811
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.65692268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.98538571
2MP0010094_abnormal_chromosome_stability4.54181700
3MP0004957_abnormal_blastocyst_morpholog4.18495364
4MP0003111_abnormal_nucleus_morphology3.85114344
5MP0008057_abnormal_DNA_replication3.82161680
6MP0003077_abnormal_cell_cycle3.78323025
7MP0008058_abnormal_DNA_repair3.63976498
8MP0008877_abnormal_DNA_methylation3.16208225
9MP0008007_abnormal_cellular_replicative3.13382606
10MP0003950_abnormal_plasma_membrane2.79901746
11MP0003123_paternal_imprinting2.77710991
12MP0008932_abnormal_embryonic_tissue2.71293795
13MP0003786_premature_aging2.52267009
14MP0000569_abnormal_digit_pigmentation2.36973789
15MP0008260_abnormal_autophagy2.26113623
16MP0005451_abnormal_body_composition2.14010898
17MP0002877_abnormal_melanocyte_morpholog2.10316193
18MP0001730_embryonic_growth_arrest2.04302774
19MP0000350_abnormal_cell_proliferation2.04105145
20MP0002210_abnormal_sex_determination1.92961894
21MP0010234_abnormal_vibrissa_follicle1.90349180
22MP0001929_abnormal_gametogenesis1.75037813
23MP0010030_abnormal_orbit_morphology1.71444479
24MP0010307_abnormal_tumor_latency1.69892507
25MP0002396_abnormal_hematopoietic_system1.63692372
26MP0002160_abnormal_reproductive_system1.62270344
27MP0001145_abnormal_male_reproductive1.61817769
28MP0003718_maternal_effect1.61383800
29MP0006035_abnormal_mitochondrial_morpho1.60192970
30MP0001697_abnormal_embryo_size1.59749899
31MP0003121_genomic_imprinting1.56150240
32MP0001672_abnormal_embryogenesis/_devel1.53956740
33MP0005380_embryogenesis_phenotype1.53956740
34MP0010352_gastrointestinal_tract_polyps1.49789892
35MP0003806_abnormal_nucleotide_metabolis1.45339844
36MP0002653_abnormal_ependyma_morphology1.44492396
37MP0001293_anophthalmia1.43855205
38MP0002080_prenatal_lethality1.41554868
39MP0000653_abnormal_sex_gland1.40368317
40MP0000685_abnormal_immune_system1.39601313
41MP0000313_abnormal_cell_death1.38215698
42MP0001835_abnormal_antigen_presentation1.38035476
43MP0002085_abnormal_embryonic_tissue1.37946305
44MP0005410_abnormal_fertilization1.37432722
45MP0003984_embryonic_growth_retardation1.37003767
46MP0004808_abnormal_hematopoietic_stem1.34046977
47MP0003315_abnormal_perineum_morphology1.33522165
48MP0000490_abnormal_crypts_of1.33423845
49MP0002088_abnormal_embryonic_growth/wei1.32426918
50MP0000372_irregular_coat_pigmentation1.30771660
51MP0009785_altered_susceptibility_to1.30182697
52MP0001881_abnormal_mammary_gland1.29994015
53MP0002084_abnormal_developmental_patter1.28988912
54MP0006072_abnormal_retinal_apoptosis1.24726620
55MP0004197_abnormal_fetal_growth/weight/1.24475442
56MP0006292_abnormal_olfactory_placode1.23566915
57MP0002019_abnormal_tumor_incidence1.21452844
58MP0003698_abnormal_male_reproductive1.19895091
59MP0010368_abnormal_lymphatic_system1.19079726
60MP0003567_abnormal_fetal_cardiomyocyte1.18027195
61MP0002938_white_spotting1.17811005
62MP0005389_reproductive_system_phenotype1.16503914
63MP0004133_heterotaxia1.15622552
64MP0003186_abnormal_redox_activity1.15251839
65MP0002086_abnormal_extraembryonic_tissu1.14183912
66MP0003941_abnormal_skin_development1.13656234
67MP0005174_abnormal_tail_pigmentation1.11226450
68MP0009333_abnormal_splenocyte_physiolog1.11091511
69MP0003890_abnormal_embryonic-extraembry1.10363987
70MP0002148_abnormal_hypersensitivity_rea1.09837255
71MP0008995_early_reproductive_senescence1.07643099
72MP0004185_abnormal_adipocyte_glucose1.07586145
73MP0006054_spinal_hemorrhage1.01608157
74MP0008438_abnormal_cutaneous_collagen1.01392514
75MP0001119_abnormal_female_reproductive1.01379911
76MP0001727_abnormal_embryo_implantation0.99995832
77MP0009764_decreased_sensitivity_to0.99755582
78MP0006036_abnormal_mitochondrial_physio0.99722704
79MP0003119_abnormal_digestive_system0.94910552
80MP0002006_tumorigenesis0.92667691
81MP0000358_abnormal_cell_content/0.90936725
82MP0009053_abnormal_anal_canal0.90801430
83MP0005379_endocrine/exocrine_gland_phen0.87382042
84MP0009379_abnormal_foot_pigmentation0.86343205
85MP0002282_abnormal_trachea_morphology0.84377928
86MP0001879_abnormal_lymphatic_vessel0.83632075
87MP0002161_abnormal_fertility/fecundity0.82642590
88MP0005076_abnormal_cell_differentiation0.81723002
89MP0003937_abnormal_limbs/digits/tail_de0.81553462
90MP0002452_abnormal_antigen_presenting0.81543996
91MP0001545_abnormal_hematopoietic_system0.81355380
92MP0005397_hematopoietic_system_phenotyp0.81355380
93MP0000015_abnormal_ear_pigmentation0.80381497
94MP0001764_abnormal_homeostasis0.80188913
95MP0001216_abnormal_epidermal_layer0.78931570
96MP0002796_impaired_skin_barrier0.78568042
97MP0005671_abnormal_response_to0.77249474
98MP0000703_abnormal_thymus_morphology0.76128691
99MP0001286_abnormal_eye_development0.75507764
100MP0008789_abnormal_olfactory_epithelium0.75235183
101MP0005623_abnormal_meninges_morphology0.74840809
102MP0005384_cellular_phenotype0.73828519
103MP0002132_abnormal_respiratory_system0.73592794
104MP0000537_abnormal_urethra_morphology0.73555843
105MP0002095_abnormal_skin_pigmentation0.72965142
106MP0001542_abnormal_bone_strength0.72625060
107MP0001919_abnormal_reproductive_system0.72417186
108MP0002751_abnormal_autonomic_nervous0.71862737
109MP0002163_abnormal_gland_morphology0.69820862
110MP0005501_abnormal_skin_physiology0.69545543
111MP0001661_extended_life_span0.69512110
112MP0002111_abnormal_tail_morphology0.69133852
113MP0001915_intracranial_hemorrhage0.67370777
114MP0005310_abnormal_salivary_gland0.66906654
115MP0002398_abnormal_bone_marrow0.66728568
116MP0003763_abnormal_thymus_physiology0.66667702
117MP0003221_abnormal_cardiomyocyte_apopto0.65619371
118MP0009672_abnormal_birth_weight0.64270051
119MP0000858_altered_metastatic_potential0.63590716
120MP0002722_abnormal_immune_system0.63473764
121MP0005084_abnormal_gallbladder_morpholo0.62981367
122MP0000627_abnormal_mammary_gland0.62335004
123MP0005000_abnormal_immune_tolerance0.62323970
124MP0002060_abnormal_skin_morphology0.62110087
125MP0005621_abnormal_cell_physiology0.62060891
126MP0000689_abnormal_spleen_morphology0.61442021
127MP0005408_hypopigmentation0.61411829
128MP0009697_abnormal_copulation0.60103485
129MP0002092_abnormal_eye_morphology0.59917580
130MP0003943_abnormal_hepatobiliary_system0.59293502
131MP0000049_abnormal_middle_ear0.58997858
132MP0000428_abnormal_craniofacial_morphol0.58238374
133MP0003122_maternal_imprinting0.58208202
134MP0003942_abnormal_urinary_system0.56986219
135MP0000516_abnormal_urinary_system0.55962620
136MP0005367_renal/urinary_system_phenotyp0.55962620
137MP0002102_abnormal_ear_morphology0.55550729
138MP0005023_abnormal_wound_healing0.54191807
139MP0001853_heart_inflammation0.54117180
140MP0002429_abnormal_blood_cell0.53890113

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.83029013
2Fibular aplasia (HP:0002990)4.51390467
3Abnormality of the anterior horn cell (HP:0006802)4.03675390
4Degeneration of anterior horn cells (HP:0002398)4.03675390
5Breast hypoplasia (HP:0003187)4.00653594
6Reticulocytopenia (HP:0001896)3.98691938
7Chromsome breakage (HP:0040012)3.68247632
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.58230872
9Carpal bone hypoplasia (HP:0001498)3.56866893
10Selective tooth agenesis (HP:0001592)3.43189445
11Lipid accumulation in hepatocytes (HP:0006561)3.39662090
12Increased hepatocellular lipid droplets (HP:0006565)3.32689306
13Volvulus (HP:0002580)3.31291784
14Supernumerary spleens (HP:0009799)3.21496125
15Abnormality of cells of the erythroid lineage (HP:0012130)3.17976368
16Colon cancer (HP:0003003)3.07755011
17Meckel diverticulum (HP:0002245)3.07153965
18Abnormal number of erythroid precursors (HP:0012131)3.06983157
1911 pairs of ribs (HP:0000878)3.02290313
20Aplastic anemia (HP:0001915)3.00475535
21Patellar aplasia (HP:0006443)2.98800219
22Abnormality of the ileum (HP:0001549)2.97300426
23Abnormality of chromosome stability (HP:0003220)2.94774021
24Oral leukoplakia (HP:0002745)2.92416834
25Agnosia (HP:0010524)2.87416670
26Abnormality of the preputium (HP:0100587)2.86231568
27Acute necrotizing encephalopathy (HP:0006965)2.83503806
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.83084557
29Medulloblastoma (HP:0002885)2.81253214
30Acute encephalopathy (HP:0006846)2.80667281
31Aplasia/Hypoplasia of the patella (HP:0006498)2.78809960
32Absent thumb (HP:0009777)2.75835237
33Rough bone trabeculation (HP:0100670)2.75246334
34Absent radius (HP:0003974)2.68153148
35Impulsivity (HP:0100710)2.61730515
36Ependymoma (HP:0002888)2.61400454
37Increased CSF lactate (HP:0002490)2.61130069
38Abnormal mitochondria in muscle tissue (HP:0008316)2.59917609
39Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.58281566
40Cerebral hypomyelination (HP:0006808)2.54233094
41Duodenal stenosis (HP:0100867)2.53785655
42Small intestinal stenosis (HP:0012848)2.53785655
43Aplasia/hypoplasia of the uterus (HP:0008684)2.52786005
44Abnormal spermatogenesis (HP:0008669)2.51376435
45Abnormal lung lobation (HP:0002101)2.51017253
46Ectopic kidney (HP:0000086)2.50129097
47Absent forearm bone (HP:0003953)2.47286170
48Aplasia involving forearm bones (HP:0009822)2.47286170
49Premature rupture of membranes (HP:0001788)2.43922271
50Renal Fanconi syndrome (HP:0001994)2.43097684
51Rhabdomyosarcoma (HP:0002859)2.40888045
52Myelodysplasia (HP:0002863)2.37486699
53Irregular epiphyses (HP:0010582)2.37414155
54Sloping forehead (HP:0000340)2.36843794
55Increased serum lactate (HP:0002151)2.34134711
56Microglossia (HP:0000171)2.33217938
57Exertional dyspnea (HP:0002875)2.33072354
58Macrocytic anemia (HP:0001972)2.32163093
59Microretrognathia (HP:0000308)2.31954245
60Neoplasm of the pancreas (HP:0002894)2.31324079
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.30241414
62Premature graying of hair (HP:0002216)2.27902455
63Abnormality of methionine metabolism (HP:0010901)2.27540820
64Facial cleft (HP:0002006)2.24846943
65Abnormal protein glycosylation (HP:0012346)2.24601553
66Abnormal glycosylation (HP:0012345)2.24601553
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24601553
68Abnormal protein N-linked glycosylation (HP:0012347)2.24601553
69Severe visual impairment (HP:0001141)2.24346627
70Blepharitis (HP:0000498)2.24081985
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23173079
72Mitochondrial inheritance (HP:0001427)2.22424520
73Horseshoe kidney (HP:0000085)2.22027242
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20668018
75Sparse eyelashes (HP:0000653)2.20606577
76Triphalangeal thumb (HP:0001199)2.18103804
77Abnormality of the labia minora (HP:0012880)2.16536644
78Secondary amenorrhea (HP:0000869)2.15647485
79Respiratory difficulties (HP:0002880)2.14936576
80Pallor (HP:0000980)2.14758896
81Atrophy/Degeneration involving motor neurons (HP:0007373)2.13912024
82Abnormality of the duodenum (HP:0002246)2.12938819
83Cerebral edema (HP:0002181)2.12685099
84Bone marrow hypocellularity (HP:0005528)2.12608417
85Progressive macrocephaly (HP:0004481)2.10340641
86Adactyly (HP:0009776)2.09078389
87Premature ovarian failure (HP:0008209)2.07281593
88Vacuolated lymphocytes (HP:0001922)2.06978827
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.05515064
90Absent epiphyses (HP:0010577)2.05515064
91Type I transferrin isoform profile (HP:0003642)2.05040637
92Nephroblastoma (Wilms tumor) (HP:0002667)2.04804253
93Cortical dysplasia (HP:0002539)2.04731368
94Cleft eyelid (HP:0000625)2.04545117
95Missing ribs (HP:0000921)2.02766453
96Hypoplastic pelvis (HP:0008839)2.02636592
97Trismus (HP:0000211)2.02378861
98Atresia of the external auditory canal (HP:0000413)2.01715967
99Abnormal number of incisors (HP:0011064)2.01479913
100Sensory axonal neuropathy (HP:0003390)2.01250061
101Abnormal trabecular bone morphology (HP:0100671)2.00717007
102Aplasia/Hypoplasia of the fibula (HP:0006492)2.00623652
103Tracheoesophageal fistula (HP:0002575)1.98934062
104Redundant skin (HP:0001582)1.97111319
105Embryonal renal neoplasm (HP:0011794)1.95477760
106Glossoptosis (HP:0000162)1.93970954
107Short thumb (HP:0009778)1.93937969
108Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93187383
109Follicular hyperkeratosis (HP:0007502)1.93151972
110Hypoplasia of the radius (HP:0002984)1.92952114
111Aplasia/Hypoplasia of the nipples (HP:0006709)1.92293899
112B lymphocytopenia (HP:0010976)1.91953650
113Abnormality of alanine metabolism (HP:0010916)1.91835174
114Hyperalaninemia (HP:0003348)1.91835174
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91835174
116Barrel-shaped chest (HP:0001552)1.91009381
117Abnormality of abdominal situs (HP:0011620)1.88618684
118Abdominal situs inversus (HP:0003363)1.88618684
119Duplicated collecting system (HP:0000081)1.88330596
120Increased nuchal translucency (HP:0010880)1.86813374
121Lactic acidosis (HP:0003128)1.86303682
122Poor head control (HP:0002421)1.84895161
123Abnormality of B cell number (HP:0010975)1.84789226
124Slender long bone (HP:0003100)1.84768256
125Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81529911
126Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81529911
127Aplasia/Hypoplasia of the sternum (HP:0006714)1.81361986
128Microvesicular hepatic steatosis (HP:0001414)1.80487465
129Hepatocellular necrosis (HP:0001404)1.80043592
130Poor speech (HP:0002465)1.79795884
131Multiple enchondromatosis (HP:0005701)1.79595685
132Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79520120
133Cutaneous melanoma (HP:0012056)1.78876974
134Pancytopenia (HP:0001876)1.77213707
135Abnormality of the renal collecting system (HP:0004742)1.76683980
136Cellular immunodeficiency (HP:0005374)1.76629810
137Ovarian neoplasm (HP:0100615)1.76449714
138Hepatic necrosis (HP:0002605)1.75637710
139Disproportionate short-trunk short stature (HP:0003521)1.75463222
140Neoplasm of the colon (HP:0100273)1.75154124
141Facial hemangioma (HP:0000329)1.73955700
142Albinism (HP:0001022)1.73859069
143Abnormality of DNA repair (HP:0003254)1.73745476
144Stenosis of the external auditory canal (HP:0000402)1.73462919
145Glioma (HP:0009733)1.72681046
146Proximal placement of thumb (HP:0009623)1.68790136
147Optic nerve coloboma (HP:0000588)1.68733714
148Increased intramyocellular lipid droplets (HP:0012240)1.68723782
149Generalized aminoaciduria (HP:0002909)1.68411882
150Abnormality of the carotid arteries (HP:0005344)1.67693278
1513-Methylglutaconic aciduria (HP:0003535)1.67076842
152Muscle fiber atrophy (HP:0100295)1.67066886
153Squamous cell carcinoma (HP:0002860)1.65997052
154Type 2 muscle fiber atrophy (HP:0003554)1.65583193
155Prolonged neonatal jaundice (HP:0006579)1.65481425
156Hypothermia (HP:0002045)1.65216989
157Thrombocytosis (HP:0001894)1.64267509
158Aplasia/hypoplasia of the humerus (HP:0006507)1.63728841
159Upper limb muscle weakness (HP:0003484)1.63441840
160Abnormality of aspartate family amino acid metabolism (HP:0010899)1.62872045
161Fatigue (HP:0012378)1.62697371
162Abnormality of liposaccharide metabolism (HP:0010968)1.62167807
163Abnormality of glycosphingolipid metabolism (HP:0004343)1.62167807
164Abnormality of glycolipid metabolism (HP:0010969)1.62167807

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.69561582
2WEE14.33734982
3MAP3K93.79847921
4CDC73.62555561
5EIF2AK13.33988634
6TAF13.05918040
7SRPK12.69736674
8ACVR1B2.61057349
9PLK42.54651879
10BRSK22.48440032
11NEK22.43086991
12VRK22.40083035
13EIF2AK32.38312344
14STK162.13449324
15PASK2.06641101
16TTK2.06042562
17ARAF2.02037642
18PLK12.01350334
19DYRK31.95136093
20TESK11.94546505
21VRK11.93283345
22MKNK11.91034189
23TIE11.88377634
24NME21.85257228
25TSSK61.85043927
26PBK1.78582670
27NEK11.73255132
28PLK31.70669064
29TESK21.68331019
30MKNK21.63105593
31ATR1.60903199
32MAP3K131.60463156
33AURKB1.51225174
34CDK71.50093182
35TLK11.45687893
36RPS6KA41.44181499
37MAP3K141.41926165
38BRSK11.38854609
39PDK41.35883118
40PDK31.35883118
41CHEK21.33551234
42AURKA1.31763333
43MAP3K121.30415290
44RPS6KB21.27305198
45SMG11.22572437
46MST1R1.19867332
47TGFBR11.18370688
48MAPKAPK51.12710052
49CHEK11.07959541
50STK101.03611211
51STK38L1.01842683
52KDR1.00433949
53MAP3K81.00008172
54PAK40.99830746
55EPHA20.99611057
56STK40.98145811
57ZAK0.95734550
58FLT30.91933244
59BCKDK0.90138634
60PIM20.89182029
61LIMK10.87411146
62CCNB10.87328199
63CDK80.86966726
64SCYL20.86843646
65ATM0.86074756
66PDK20.85996111
67MET0.85727750
68EIF2AK20.82015382
69MST40.81830388
70STK30.81708498
71CDK40.78749566
72CSNK2A10.78149951
73PIM10.75543607
74RAF10.75300054
75GRK10.74487892
76KSR10.72173116
77DYRK20.70486102
78CDK20.70237117
79BMPR20.70086237
80ERBB40.69740659
81TRIM280.69044219
82CSNK2A20.68091629
83CDK120.64429654
84PAK10.63907171
85PIK3CG0.62542021
86BRAF0.61321223
87NUAK10.59849573
88CDK190.59051650
89MOS0.57964122
90CDK90.56271924
91CDK10.56089601
92ABL20.54887729
93CAMKK20.54208718
94TEC0.52915572
95RPS6KA50.51565846
96JAK30.50497906
97BCR0.49066351
98MELK0.48826850
99NME10.48750060
100MAPKAPK30.48237240
101PRKCI0.48190224
102CSNK1G30.47827744
103TAOK20.47639710
104ADRBK20.47443924
105IKBKB0.47325850
106TAOK30.46529193
107STK240.46340883
108IRAK40.45837524
109NEK90.44233709
110MAP3K110.42361443
111BRD40.41249544
112MAP3K100.40828495
113MATK0.39097875
114CSNK1A1L0.38690300
115CDK60.37113855
116MAP3K30.36640003
117LRRK20.35548760
118YES10.33956865
119BMPR1B0.33758497
120AKT30.33081183
121LATS10.30828844
122ALK0.30498440
123ERBB30.29418361
124PNCK0.28272669
125PRKDC0.27358305
126DYRK1B0.26914499
127ILK0.22723109
128BTK0.21581942
129MAPKAPK20.21168998
130PLK20.17176893
131WNK30.16080079
132IRAK30.15709069
133CLK10.15661458

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.60192314
2Mismatch repair_Homo sapiens_hsa034304.16383715
3Proteasome_Homo sapiens_hsa030503.74399192
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.57718529
5Spliceosome_Homo sapiens_hsa030403.27339887
6Ribosome_Homo sapiens_hsa030103.24837315
7RNA polymerase_Homo sapiens_hsa030203.21889072
8RNA transport_Homo sapiens_hsa030133.11606542
9Homologous recombination_Homo sapiens_hsa034403.10798330
10Nucleotide excision repair_Homo sapiens_hsa034202.95737159
11Base excision repair_Homo sapiens_hsa034102.91085095
12Cell cycle_Homo sapiens_hsa041102.70089812
13Fanconi anemia pathway_Homo sapiens_hsa034602.43243559
14Pyrimidine metabolism_Homo sapiens_hsa002402.42536981
15* Basal transcription factors_Homo sapiens_hsa030222.36850663
16One carbon pool by folate_Homo sapiens_hsa006702.31227329
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26512890
18Non-homologous end-joining_Homo sapiens_hsa034502.19639373
19RNA degradation_Homo sapiens_hsa030182.00011542
20Protein export_Homo sapiens_hsa030601.83081631
21mRNA surveillance pathway_Homo sapiens_hsa030151.74371029
22Sulfur metabolism_Homo sapiens_hsa009201.67029229
23p53 signaling pathway_Homo sapiens_hsa041151.56656608
24Purine metabolism_Homo sapiens_hsa002301.39537355
25* Epstein-Barr virus infection_Homo sapiens_hsa051691.22097885
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15047232
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10687485
28Asthma_Homo sapiens_hsa053101.09935577
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07384578
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.05268499
31Oocyte meiosis_Homo sapiens_hsa041141.03459359
32Huntingtons disease_Homo sapiens_hsa050160.95328833
33Selenocompound metabolism_Homo sapiens_hsa004500.94386160
34Folate biosynthesis_Homo sapiens_hsa007900.93866953
35Fatty acid elongation_Homo sapiens_hsa000620.92530264
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92206265
37Antigen processing and presentation_Homo sapiens_hsa046120.90128833
38Herpes simplex infection_Homo sapiens_hsa051680.89338434
39Systemic lupus erythematosus_Homo sapiens_hsa053220.85290439
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84952153
41Pentose phosphate pathway_Homo sapiens_hsa000300.82211759
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81222972
43Steroid biosynthesis_Homo sapiens_hsa001000.80740904
44Rheumatoid arthritis_Homo sapiens_hsa053230.79601987
45* Viral carcinogenesis_Homo sapiens_hsa052030.78835133
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77130331
47Legionellosis_Homo sapiens_hsa051340.76500031
48Parkinsons disease_Homo sapiens_hsa050120.70436420
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70415765
50Autoimmune thyroid disease_Homo sapiens_hsa053200.68921428
51Glutathione metabolism_Homo sapiens_hsa004800.67775619
52HTLV-I infection_Homo sapiens_hsa051660.66551912
53Pyruvate metabolism_Homo sapiens_hsa006200.66120187
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.64384791
55Graft-versus-host disease_Homo sapiens_hsa053320.64325002
56Propanoate metabolism_Homo sapiens_hsa006400.64103690
57Vitamin B6 metabolism_Homo sapiens_hsa007500.61743848
58Biosynthesis of amino acids_Homo sapiens_hsa012300.58795031
59Thyroid cancer_Homo sapiens_hsa052160.58692608
60Sulfur relay system_Homo sapiens_hsa041220.58052529
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57607464
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56912764
63Oxidative phosphorylation_Homo sapiens_hsa001900.55880412
64N-Glycan biosynthesis_Homo sapiens_hsa005100.54844836
65Type I diabetes mellitus_Homo sapiens_hsa049400.53990517
66TGF-beta signaling pathway_Homo sapiens_hsa043500.48907803
67Lysosome_Homo sapiens_hsa041420.48701379
68Viral myocarditis_Homo sapiens_hsa054160.47977145
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.47759697
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47721954
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46745552
72Sphingolipid metabolism_Homo sapiens_hsa006000.46653041
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46207478
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44707094
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44406513
76Hippo signaling pathway_Homo sapiens_hsa043900.43560275
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42170583
78Small cell lung cancer_Homo sapiens_hsa052220.41952802
79Leishmaniasis_Homo sapiens_hsa051400.41776223
80Vibrio cholerae infection_Homo sapiens_hsa051100.40940294
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40498662
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39792449
83MicroRNAs in cancer_Homo sapiens_hsa052060.38081738
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36698094
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36615703
86Arachidonic acid metabolism_Homo sapiens_hsa005900.36258469
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35881480
88Fructose and mannose metabolism_Homo sapiens_hsa000510.35740329
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.34727533
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34386774
91Basal cell carcinoma_Homo sapiens_hsa052170.33178392
92Fatty acid biosynthesis_Homo sapiens_hsa000610.33103524
93Carbon metabolism_Homo sapiens_hsa012000.32621591
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32265592
95Apoptosis_Homo sapiens_hsa042100.31867493
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31482890
97TNF signaling pathway_Homo sapiens_hsa046680.30409168
98Galactose metabolism_Homo sapiens_hsa000520.29830762
99Shigellosis_Homo sapiens_hsa051310.28525255
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28027590
101Hepatitis C_Homo sapiens_hsa051600.27900340
102Alcoholism_Homo sapiens_hsa050340.27873245
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27851518
104Measles_Homo sapiens_hsa051620.27253075
105Metabolic pathways_Homo sapiens_hsa011000.26409304
106Hedgehog signaling pathway_Homo sapiens_hsa043400.23257096
107Colorectal cancer_Homo sapiens_hsa052100.23123294
108Hepatitis B_Homo sapiens_hsa051610.22750716
109HIF-1 signaling pathway_Homo sapiens_hsa040660.22441689
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21893487
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.21525230
112Renin-angiotensin system_Homo sapiens_hsa046140.20897000
113Primary immunodeficiency_Homo sapiens_hsa053400.20105244
114Pathways in cancer_Homo sapiens_hsa052000.18749046
115Influenza A_Homo sapiens_hsa051640.18265988
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.17469904
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17380758
118Notch signaling pathway_Homo sapiens_hsa043300.15395078
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.14962932
120Allograft rejection_Homo sapiens_hsa053300.14922904
121Bladder cancer_Homo sapiens_hsa052190.14319479
122Linoleic acid metabolism_Homo sapiens_hsa005910.13936004
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12476060
124Regulation of autophagy_Homo sapiens_hsa041400.11953633
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11543867
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11433943
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10940265
128Prostate cancer_Homo sapiens_hsa052150.10934728
129Alzheimers disease_Homo sapiens_hsa050100.10259056
130Adherens junction_Homo sapiens_hsa045200.09275469

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