GTF2H1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.45811796
2nuclear pore complex assembly (GO:0051292)5.37928087
3nuclear pore organization (GO:0006999)5.31078921
4protein localization to kinetochore (GO:0034501)4.52620338
5mitotic nuclear envelope disassembly (GO:0007077)4.48763282
6ribosome assembly (GO:0042255)4.39859245
7nucleobase biosynthetic process (GO:0046112)4.38363900
8mitotic metaphase plate congression (GO:0007080)4.33869450
9folic acid-containing compound biosynthetic process (GO:0009396)4.30836339
10purine nucleobase biosynthetic process (GO:0009113)4.29290730
11DNA unwinding involved in DNA replication (GO:0006268)4.28402478
12formation of translation preinitiation complex (GO:0001731)4.26230271
13nuclear envelope disassembly (GO:0051081)4.25314276
14membrane disassembly (GO:0030397)4.25314276
15DNA replication-dependent nucleosome assembly (GO:0006335)4.19061433
16DNA replication-dependent nucleosome organization (GO:0034723)4.19061433
17pore complex assembly (GO:0046931)4.18782842
18DNA replication initiation (GO:0006270)4.14151901
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.13530240
20protein localization to chromosome, centromeric region (GO:0071459)4.04400419
21non-recombinational repair (GO:0000726)3.94783325
22double-strand break repair via nonhomologous end joining (GO:0006303)3.94783325
23regulation of spindle organization (GO:0090224)3.94301388
24establishment of integrated proviral latency (GO:0075713)3.94201600
25transcription from mitochondrial promoter (GO:0006390)3.85780423
26DNA replication checkpoint (GO:0000076)3.84397371
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.83200993
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.83154956
29DNA strand elongation involved in DNA replication (GO:0006271)3.79057632
30anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.76222326
31IMP biosynthetic process (GO:0006188)3.75699395
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.73659147
33mitotic chromosome condensation (GO:0007076)3.69950007
34positive regulation of chromosome segregation (GO:0051984)3.68250857
35maturation of SSU-rRNA (GO:0030490)3.66415190
36metaphase plate congression (GO:0051310)3.64336452
37ribosome biogenesis (GO:0042254)3.64029865
38regulation of translational termination (GO:0006449)3.63273766
39DNA strand elongation (GO:0022616)3.56283384
40regulation of mitotic spindle organization (GO:0060236)3.54461960
41amino acid activation (GO:0043038)3.53147184
42tRNA aminoacylation (GO:0043039)3.53147184
43folic acid metabolic process (GO:0046655)3.52693824
44tRNA aminoacylation for protein translation (GO:0006418)3.51673755
45mitochondrial RNA metabolic process (GO:0000959)3.49766682
46cullin deneddylation (GO:0010388)3.49031154
47protein heterotetramerization (GO:0051290)3.48572660
48chaperone-mediated protein complex assembly (GO:0051131)3.48542452
49chromatin remodeling at centromere (GO:0031055)3.47720024
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.47139189
51nuclear envelope organization (GO:0006998)3.43503634
52regulation of centrosome cycle (GO:0046605)3.40470606
53IMP metabolic process (GO:0046040)3.38543711
54mitotic sister chromatid segregation (GO:0000070)3.37910619
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.37276353
56negative regulation of ligase activity (GO:0051352)3.37276353
57regulation of histone H3-K9 methylation (GO:0051570)3.35835900
58protein deneddylation (GO:0000338)3.34835392
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34332474
60CENP-A containing nucleosome assembly (GO:0034080)3.32087752
61somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.31337967
62somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.31337967
63isotype switching (GO:0045190)3.31337967
64establishment of viral latency (GO:0019043)3.30200535
65sister chromatid segregation (GO:0000819)3.29768462
66DNA double-strand break processing (GO:0000729)3.29086464
67regulation of chromosome segregation (GO:0051983)3.24996273
68histone exchange (GO:0043486)3.24159729
69ribonucleoprotein complex disassembly (GO:0032988)3.24139861
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.24069725
71attachment of spindle microtubules to kinetochore (GO:0008608)3.23855969
72monoubiquitinated protein deubiquitination (GO:0035520)3.23419067
73establishment of chromosome localization (GO:0051303)3.22814272
74DNA geometric change (GO:0032392)3.22673401
75DNA duplex unwinding (GO:0032508)3.22349864
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.22318357
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.22318357
78regulation of cellular amino acid metabolic process (GO:0006521)3.20503249
79positive regulation of ligase activity (GO:0051351)3.19868012
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18838274
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18838274
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18838274
83telomere maintenance via semi-conservative replication (GO:0032201)3.18408857
84kinetochore organization (GO:0051383)3.16361001
85heterochromatin organization (GO:0070828)3.16247628
86DNA replication-independent nucleosome organization (GO:0034724)3.16162802
87DNA replication-independent nucleosome assembly (GO:0006336)3.16162802
88tRNA methylation (GO:0030488)3.15001411
89ribonucleoprotein complex biogenesis (GO:0022613)3.14636909
90mitotic sister chromatid cohesion (GO:0007064)3.11394104
91regulation of centriole replication (GO:0046599)3.11262446
92signal transduction involved in DNA damage checkpoint (GO:0072422)3.10430861
93signal transduction involved in DNA integrity checkpoint (GO:0072401)3.10430861
94response to X-ray (GO:0010165)3.08781890
95spindle checkpoint (GO:0031577)3.07689084
96telomere maintenance via recombination (GO:0000722)3.06148030
97COPII vesicle coating (GO:0048208)3.04818716
98mitotic recombination (GO:0006312)3.04717373
99signal transduction involved in cell cycle checkpoint (GO:0072395)3.03677336
100negative regulation of histone methylation (GO:0031061)3.03386787
101regulation of translation in response to stress (GO:0043555)3.00649042
102synaptonemal complex assembly (GO:0007130)3.00643949
103protein K6-linked ubiquitination (GO:0085020)2.99903298
104regulation of RNA export from nucleus (GO:0046831)2.98122899
105negative regulation of chromosome segregation (GO:0051985)2.97855709
106regulation of sister chromatid cohesion (GO:0007063)2.97315534
107regulation of ubiquitin-protein transferase activity (GO:0051438)2.96433027
108ribosomal large subunit biogenesis (GO:0042273)2.95771796
109regulation of mitotic metaphase/anaphase transition (GO:0030071)2.95057689
110protein localization to chromosome (GO:0034502)2.94026091
111mitotic spindle checkpoint (GO:0071174)2.94011495
112negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93578892
113negative regulation of sister chromatid segregation (GO:0033046)2.93578892
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.93578892
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93578892
116chromatin assembly or disassembly (GO:0006333)2.92975108
117regulation of sister chromatid segregation (GO:0033045)2.91664161
118regulation of mitotic sister chromatid separation (GO:0010965)2.91664161
119DNA ligation (GO:0006266)2.90556323
120meiotic chromosome segregation (GO:0045132)2.89532379
121piRNA metabolic process (GO:0034587)2.89411152
122rRNA processing (GO:0006364)2.89221811
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88890537
124spindle assembly checkpoint (GO:0071173)2.88798776
125regulation of gene silencing by RNA (GO:0060966)2.88336085
126regulation of posttranscriptional gene silencing (GO:0060147)2.88336085
127regulation of gene silencing by miRNA (GO:0060964)2.88336085
128mitotic spindle assembly checkpoint (GO:0007094)2.85982828
129regulation of ligase activity (GO:0051340)2.85902477
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85641365
131somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84898618
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.84898618
133chromosome condensation (GO:0030261)2.84398136
134lipopolysaccharide biosynthetic process (GO:0009103)2.84006011
135positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82888307
136positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82888307
137positive regulation of mitotic sister chromatid separation (GO:1901970)2.82888307
138G1/S transition of mitotic cell cycle (GO:0000082)2.82872148
139cell cycle G1/S phase transition (GO:0044843)2.82872148
140DNA catabolic process, exonucleolytic (GO:0000738)2.82860240
141chromosome segregation (GO:0007059)2.82738765
142rRNA metabolic process (GO:0016072)2.82589775
143chromatin assembly (GO:0031497)2.82572290
144mitotic G1 DNA damage checkpoint (GO:0031571)2.82007341
145spliceosomal snRNP assembly (GO:0000387)2.81944194
146resolution of meiotic recombination intermediates (GO:0000712)2.81832547
147nucleobase-containing small molecule interconversion (GO:0015949)2.81334280
148DNA conformation change (GO:0071103)2.80693667
149maturation of 5.8S rRNA (GO:0000460)2.78914338
150histone-serine phosphorylation (GO:0035404)2.77502947
151synaptonemal complex organization (GO:0070193)2.76934593
152organelle disassembly (GO:1903008)2.74496443
153rRNA methylation (GO:0031167)2.74344091
154regulation of mitotic sister chromatid segregation (GO:0033047)2.73695765
155replication fork processing (GO:0031297)2.72953417
156mitochondrial DNA replication (GO:0006264)2.70496929

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.22272306
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.13338124
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.01949053
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42680595
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.28557008
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.24069977
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92020561
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88639672
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68106747
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55159435
11* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51037051
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.49986282
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47280064
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39438922
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.39100195
16AR_21909140_ChIP-Seq_LNCAP_Human2.38642187
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.38046956
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.34731803
19* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23919317
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.16636327
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10365141
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07691507
23* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.05013645
24VDR_23849224_ChIP-Seq_CD4+_Human2.01715651
25XRN2_22483619_ChIP-Seq_HELA_Human1.99138282
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.93499197
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88830310
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88021446
29DCP1A_22483619_ChIP-Seq_HELA_Human1.84343592
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.80796558
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79437694
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75649665
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74434814
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74135220
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73898953
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73669336
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.73470231
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72064644
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72011121
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69479984
41SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.64166806
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63865916
43GABP_19822575_ChIP-Seq_HepG2_Human1.63131992
44FOXP3_21729870_ChIP-Seq_TREG_Human1.61508435
45ELK1_19687146_ChIP-ChIP_HELA_Human1.61411798
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56879109
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56352454
48KDM5A_27292631_Chip-Seq_BREAST_Human1.50362990
49TTF2_22483619_ChIP-Seq_HELA_Human1.48080731
50* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44286672
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.38340553
52BRD4_25478319_ChIP-Seq_HGPS_Human1.38297785
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37274440
54MYC_22102868_ChIP-Seq_BL_Human1.36441922
55* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35992663
56TFEB_21752829_ChIP-Seq_HELA_Human1.35132007
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32614275
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31661946
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28446373
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28362052
61FUS_26573619_Chip-Seq_HEK293_Human1.28316362
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26913325
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25852841
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25260226
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.25218507
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24079128
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24036904
68* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22440236
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22313974
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22073637
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.20721281
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.20721281
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.20721281
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19024834
75GATA1_22025678_ChIP-Seq_K562_Human1.18448494
76EWS_26573619_Chip-Seq_HEK293_Human1.16985515
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16846524
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14870021
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14468641
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.12780526
81CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12437326
82* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11481573
83CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11365711
84* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10853680
85ELF5_23300383_ChIP-Seq_T47D_Human1.10659376
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10398805
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10223323
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09190976
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08168873
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07240169
91* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06749532
92MYC_18940864_ChIP-ChIP_HL60_Human1.06131228
93* CIITA_25753668_ChIP-Seq_RAJI_Human1.04423161
94SOX17_20123909_ChIP-Seq_XEN_Mouse1.04216535
95ZNF263_19887448_ChIP-Seq_K562_Human1.04141388
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03385016
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.02452414
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02193657
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01498398
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.01124876
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00789513
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99228644
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96510154
104ZNF274_21170338_ChIP-Seq_K562_Hela0.94403273
105FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94239842
106ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94087583
107NANOG_21062744_ChIP-ChIP_HESCs_Human0.93409855
108SRF_21415370_ChIP-Seq_HL-1_Mouse0.89644170
109ZFP57_27257070_Chip-Seq_ESCs_Mouse0.89243910
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88811675
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86810092
112SALL4_22934838_ChIP-ChIP_CD34+_Human0.86740865
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86609760
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86266812
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86086902
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85998564
117* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85947410
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85298091
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83664340
120NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83655400
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83655400
122SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83626712
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83411077
124* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83182786
125* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82547914
126* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82547914
127* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82518581
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81755179
129MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81639048
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81633273
131TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81616092
132EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.80917470
133BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80783605
134IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79717746
135SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79257829
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.78063172
137CHD1_26751641_Chip-Seq_LNCaP_Human0.77992281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.07773725
2MP0003111_abnormal_nucleus_morphology4.18649896
3MP0004957_abnormal_blastocyst_morpholog4.16870561
4MP0010094_abnormal_chromosome_stability4.06506891
5MP0008057_abnormal_DNA_replication3.95545041
6MP0003077_abnormal_cell_cycle3.55368149
7MP0010352_gastrointestinal_tract_polyps3.17151626
8MP0000015_abnormal_ear_pigmentation2.92489446
9MP0010307_abnormal_tumor_latency2.77088206
10MP0000569_abnormal_digit_pigmentation2.74395332
11MP0005075_abnormal_melanosome_morpholog2.57410407
12MP0001730_embryonic_growth_arrest2.55870021
13MP0003806_abnormal_nucleotide_metabolis2.55270129
14MP0008058_abnormal_DNA_repair2.54251229
15MP0008007_abnormal_cellular_replicative2.41953182
16MP0009697_abnormal_copulation2.40280150
17MP0000350_abnormal_cell_proliferation2.20939053
18MP0008932_abnormal_embryonic_tissue2.14716758
19MP0003705_abnormal_hypodermis_morpholog2.09333937
20MP0002095_abnormal_skin_pigmentation2.09190216
21MP0003786_premature_aging1.87305324
22MP0008877_abnormal_DNA_methylation1.85435837
23MP0003123_paternal_imprinting1.82462234
24MP0001672_abnormal_embryogenesis/_devel1.78623517
25MP0005380_embryogenesis_phenotype1.78623517
26MP0003718_maternal_effect1.76941487
27MP0001697_abnormal_embryo_size1.74286239
28MP0008260_abnormal_autophagy1.73511778
29MP0004197_abnormal_fetal_growth/weight/1.65315385
30MP0002090_abnormal_vision1.65218115
31MP0005174_abnormal_tail_pigmentation1.65107217
32MP0006036_abnormal_mitochondrial_physio1.62607199
33MP0002210_abnormal_sex_determination1.61059517
34MP0002080_prenatal_lethality1.60748567
35MP0003656_abnormal_erythrocyte_physiolo1.60069241
36MP0006035_abnormal_mitochondrial_morpho1.59437561
37MP0003984_embryonic_growth_retardation1.59268933
38MP0002088_abnormal_embryonic_growth/wei1.55774641
39MP0004233_abnormal_muscle_weight1.55643939
40MP0002086_abnormal_extraembryonic_tissu1.53967015
41MP0001929_abnormal_gametogenesis1.53174207
42MP0005408_hypopigmentation1.52850021
43MP0003941_abnormal_skin_development1.50535966
44MP0005076_abnormal_cell_differentiation1.47186124
45MP0002084_abnormal_developmental_patter1.44948229
46MP0002085_abnormal_embryonic_tissue1.43754335
47MP0001145_abnormal_male_reproductive1.42233704
48MP0002102_abnormal_ear_morphology1.39187252
49MP0002396_abnormal_hematopoietic_system1.37125423
50MP0000490_abnormal_crypts_of1.35686119
51MP0002877_abnormal_melanocyte_morpholog1.30908575
52MP0005275_abnormal_skin_tensile1.30080683
53MP0000371_diluted_coat_color1.27977638
54MP0002019_abnormal_tumor_incidence1.27754734
55MP0004808_abnormal_hematopoietic_stem1.27662000
56MP0000313_abnormal_cell_death1.26160953
57MP0004272_abnormal_basement_membrane1.22142681
58MP0005410_abnormal_fertilization1.22120474
59MP0000653_abnormal_sex_gland1.21522407
60MP0002060_abnormal_skin_morphology1.19498038
61MP0000358_abnormal_cell_content/1.19000804
62MP0000749_muscle_degeneration1.16909355
63MP0003566_abnormal_cell_adhesion1.15983456
64MP0005023_abnormal_wound_healing1.11031123
65MP0001542_abnormal_bone_strength1.10671948
66MP0003567_abnormal_fetal_cardiomyocyte1.08670353
67MP0003186_abnormal_redox_activity1.07911287
68MP0000427_abnormal_hair_cycle1.06493616
69MP0009840_abnormal_foam_cell1.05656543
70MP0000372_irregular_coat_pigmentation1.05518037
71MP0010234_abnormal_vibrissa_follicle1.04757353
72MP0009333_abnormal_splenocyte_physiolog1.01117850
73MP0001324_abnormal_eye_pigmentation0.99994991
74MP0005197_abnormal_uvea_morphology0.98942274
75MP0001243_abnormal_dermal_layer0.98226624
76MP0005397_hematopoietic_system_phenotyp0.97104763
77MP0001545_abnormal_hematopoietic_system0.97104763
78MP0005501_abnormal_skin_physiology0.95760359
79MP0005621_abnormal_cell_physiology0.95626963
80MP0005165_increased_susceptibility_to0.94789861
81MP0001853_heart_inflammation0.94239342
82MP0003698_abnormal_male_reproductive0.94034772
83MP0001293_anophthalmia0.93258913
84MP0000647_abnormal_sebaceous_gland0.92874980
85MP0004264_abnormal_extraembryonic_tissu0.92828334
86MP0005384_cellular_phenotype0.92742583
87MP0000733_abnormal_muscle_development0.90444080
88MP0002269_muscular_atrophy0.90419240
89MP0003890_abnormal_embryonic-extraembry0.90194150
90MP0003221_abnormal_cardiomyocyte_apopto0.88734563
91MP0009672_abnormal_birth_weight0.86005039
92MP0001915_intracranial_hemorrhage0.85301181
93MP0009703_decreased_birth_body0.83489685
94MP0001661_extended_life_span0.82617742
95MP0001191_abnormal_skin_condition0.82443133
96MP0002653_abnormal_ependyma_morphology0.82154308
97MP0008438_abnormal_cutaneous_collagen0.81882350
98MP0004185_abnormal_adipocyte_glucose0.81025545
99MP0002161_abnormal_fertility/fecundity0.80078347
100MP0003878_abnormal_ear_physiology0.79141624
101MP0005377_hearing/vestibular/ear_phenot0.79141624
102MP0002075_abnormal_coat/hair_pigmentati0.78693048
103MP0001764_abnormal_homeostasis0.78116952
104MP0003136_yellow_coat_color0.77875914
105MP0005171_absent_coat_pigmentation0.77207446
106MP0004215_abnormal_myocardial_fiber0.76967223
107MP0000343_altered_response_to0.76420758
108MP0005389_reproductive_system_phenotype0.75806284
109MP0000689_abnormal_spleen_morphology0.74870730
110MP0003191_abnormal_cellular_cholesterol0.73942422
111MP0002722_abnormal_immune_system0.73376111
112MP0010386_abnormal_urinary_bladder0.73326843
113MP0002092_abnormal_eye_morphology0.72360278
114MP0002160_abnormal_reproductive_system0.71792572
115MP0003315_abnormal_perineum_morphology0.71523252
116MP0005395_other_phenotype0.70608231
117MP0000858_altered_metastatic_potential0.69954757
118MP0000703_abnormal_thymus_morphology0.69118294
119MP0000598_abnormal_liver_morphology0.68853578
120MP0003448_altered_tumor_morphology0.68235482
121MP0005367_renal/urinary_system_phenotyp0.67134497
122MP0000516_abnormal_urinary_system0.67134497
123MP0002332_abnormal_exercise_endurance0.67017303
124MP0000537_abnormal_urethra_morphology0.66793214
125MP0001849_ear_inflammation0.65830252
126MP0000627_abnormal_mammary_gland0.65518794
127MP0005253_abnormal_eye_physiology0.65418544
128MP0005257_abnormal_intraocular_pressure0.65144928
129MP0002398_abnormal_bone_marrow0.64385631
130MP0001216_abnormal_epidermal_layer0.64067474
131MP0003950_abnormal_plasma_membrane0.63943904
132MP0005266_abnormal_metabolism0.63698189
133MP0010678_abnormal_skin_adnexa0.63158275
134MP0002177_abnormal_outer_ear0.62622219
135MP0001119_abnormal_female_reproductive0.62496103
136MP0006054_spinal_hemorrhage0.62182593
137MP0003699_abnormal_female_reproductive0.61468865
138MP0005193_abnormal_anterior_eye0.61335410
139MP0002111_abnormal_tail_morphology0.61077319
140MP0002796_impaired_skin_barrier0.60554002
141MP0000477_abnormal_intestine_morphology0.58879357
142MP0001186_pigmentation_phenotype0.58424871
143MP0003453_abnormal_keratinocyte_physiol0.57694194
144MP0003936_abnormal_reproductive_system0.57194681
145MP0002234_abnormal_pharynx_morphology0.56633954
146MP0005058_abnormal_lysosome_morphology0.56078783
147MP0003943_abnormal_hepatobiliary_system0.56077880
148MP0010771_integument_phenotype0.55779474

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.77867766
2Breast hypoplasia (HP:0003187)4.53181042
3Carpal bone hypoplasia (HP:0001498)3.61852701
4Abnormality of the anterior horn cell (HP:0006802)3.61700146
5Degeneration of anterior horn cells (HP:0002398)3.61700146
6Ependymoma (HP:0002888)3.58153269
7Increased serum pyruvate (HP:0003542)3.54546042
8Albinism (HP:0001022)3.41808335
9Selective tooth agenesis (HP:0001592)3.39792020
10Impulsivity (HP:0100710)3.32215845
11Abnormality of glycolysis (HP:0004366)3.31150982
12Agnosia (HP:0010524)3.23360658
13Multiple enchondromatosis (HP:0005701)3.07651343
14Rhabdomyosarcoma (HP:0002859)2.98417765
15Patchy hypopigmentation of hair (HP:0011365)2.92158702
16Cerebral hypomyelination (HP:0006808)2.86349703
17Hypoplasia of the fovea (HP:0007750)2.83938071
18Aplasia/Hypoplasia of the fovea (HP:0008060)2.83938071
19Osteolytic defects of the phalanges of the hand (HP:0009771)2.81156083
20Osteolytic defects of the hand bones (HP:0009699)2.81156083
21Abnormality of methionine metabolism (HP:0010901)2.77279390
22Abnormality of chromosome stability (HP:0003220)2.76427865
23Oral leukoplakia (HP:0002745)2.75662390
24Rough bone trabeculation (HP:0100670)2.73679941
25Follicular hyperkeratosis (HP:0007502)2.73267619
26Colon cancer (HP:0003003)2.69080328
27Volvulus (HP:0002580)2.64521388
28Aplasia/hypoplasia of the humerus (HP:0006507)2.62293072
29Abnormality of the labia minora (HP:0012880)2.58174146
30Absent radius (HP:0003974)2.55422304
31Increased CSF lactate (HP:0002490)2.55374581
32Biliary tract neoplasm (HP:0100574)2.54005335
33Chromsome breakage (HP:0040012)2.53000252
34Abnormal auditory evoked potentials (HP:0006958)2.52979436
35Reticulocytopenia (HP:0001896)2.52700146
36Patellar aplasia (HP:0006443)2.51454889
37Personality changes (HP:0000751)2.51262956
38Increased serum lactate (HP:0002151)2.46977857
39Increased hepatocellular lipid droplets (HP:0006565)2.46733555
40Premature ovarian failure (HP:0008209)2.46579964
41Astrocytoma (HP:0009592)2.46374775
42Abnormality of the astrocytes (HP:0100707)2.46374775
43White forelock (HP:0002211)2.45518953
44Premature rupture of membranes (HP:0001788)2.45416210
45Secondary amenorrhea (HP:0000869)2.44467638
46Aplasia/Hypoplasia of the patella (HP:0006498)2.41649360
47Medulloblastoma (HP:0002885)2.41441975
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.39674842
49Prominent nose (HP:0000448)2.39663926
50Abnormality of the fovea (HP:0000493)2.39022868
51Pelvic girdle muscle weakness (HP:0003749)2.37721801
52Myelodysplasia (HP:0002863)2.36784485
53Papillary thyroid carcinoma (HP:0002895)2.35735942
54Poor head control (HP:0002421)2.35552055
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.35029675
56Reduced subcutaneous adipose tissue (HP:0003758)2.33664438
57Aplasia involving forearm bones (HP:0009822)2.30177753
58Absent forearm bone (HP:0003953)2.30177753
59Absent thumb (HP:0009777)2.30015851
60Short humerus (HP:0005792)2.29769997
61Meckel diverticulum (HP:0002245)2.29116462
62Premature graying of hair (HP:0002216)2.28395037
63Cutaneous melanoma (HP:0012056)2.27897167
64Sensory axonal neuropathy (HP:0003390)2.27887710
65Abnormal mitochondria in muscle tissue (HP:0008316)2.27743424
66Facial hemangioma (HP:0000329)2.26659825
67Trismus (HP:0000211)2.25469129
68Neoplasm of the pancreas (HP:0002894)2.24903159
69Azoospermia (HP:0000027)2.23757324
70Hypoplasia of the capital femoral epiphysis (HP:0003090)2.23286602
71Thyroid carcinoma (HP:0002890)2.23202342
72Proximal placement of thumb (HP:0009623)2.22826663
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.22633870
74Abnormal protein N-linked glycosylation (HP:0012347)2.22633870
75Abnormal protein glycosylation (HP:0012346)2.22633870
76Abnormal glycosylation (HP:0012345)2.22633870
77Methylmalonic acidemia (HP:0002912)2.21516771
78Microglossia (HP:0000171)2.20509716
79B lymphocytopenia (HP:0010976)2.19854278
80Atrophy/Degeneration involving motor neurons (HP:0007373)2.19798235
81Deviation of the thumb (HP:0009603)2.19727838
82Stillbirth (HP:0003826)2.19687543
83Supernumerary spleens (HP:0009799)2.17972970
84Glioma (HP:0009733)2.17831142
85Neoplasm of the peripheral nervous system (HP:0100007)2.16747117
86Abnormal spermatogenesis (HP:0008669)2.16091398
87Metaphyseal cupping (HP:0003021)2.14413981
88Acute necrotizing encephalopathy (HP:0006965)2.13640735
89Abnormality of the ileum (HP:0001549)2.13583592
90Abnormality of the preputium (HP:0100587)2.12821433
91Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12619380
92Horizontal nystagmus (HP:0000666)2.12184444
93Hypokinesia (HP:0002375)2.11272955
94Type I transferrin isoform profile (HP:0003642)2.10539557
95Neoplasm of the oral cavity (HP:0100649)2.09814053
96Autoamputation (HP:0001218)2.09599758
97Sloping forehead (HP:0000340)2.09038695
98Ankle contracture (HP:0006466)2.08575232
99Squamous cell carcinoma (HP:0002860)2.08341173
100Abnormal biliary tract morphology (HP:0012440)2.07701374
101Abnormality of alanine metabolism (HP:0010916)2.07178636
102Hyperalaninemia (HP:0003348)2.07178636
103Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07178636
104Spinal muscular atrophy (HP:0007269)2.07114971
105Renal Fanconi syndrome (HP:0001994)2.06824170
106Posterior subcapsular cataract (HP:0007787)2.06208520
107Progressive macrocephaly (HP:0004481)2.05786505
108Upper motor neuron abnormality (HP:0002127)2.05445363
109Microvesicular hepatic steatosis (HP:0001414)2.05342325
110Abnormality of the umbilical cord (HP:0010881)2.05108750
111Generalized hypopigmentation (HP:0007513)2.04716252
112Delayed gross motor development (HP:0002194)2.04638363
113Shoulder girdle muscle weakness (HP:0003547)2.04435376
114Abnormality of cells of the erythroid lineage (HP:0012130)2.03549378
115Small epiphyses (HP:0010585)2.03167841
116Orthostatic hypotension (HP:0001278)2.02497506
117Entropion (HP:0000621)2.01931753
118Short nail (HP:0001799)2.01647600
119Basal cell carcinoma (HP:0002671)2.00638762
120Poikiloderma (HP:0001029)1.99824672
121Abnormal umbilical cord blood vessels (HP:0011403)1.99593690
122Single umbilical artery (HP:0001195)1.99593690
123Abnormality of the fetal cardiovascular system (HP:0010948)1.99593690
124Bone marrow hypocellularity (HP:0005528)1.99489740
125Redundant skin (HP:0001582)1.99113736
126Abnormality of the lower motor neuron (HP:0002366)1.99100583
127Cafe-au-lait spot (HP:0000957)1.98920487
128Lipid accumulation in hepatocytes (HP:0006561)1.98685703
129Abnormal trabecular bone morphology (HP:0100671)1.98604241
130Mitochondrial inheritance (HP:0001427)1.98542202
131Spastic diplegia (HP:0001264)1.98356117
132Reduced antithrombin III activity (HP:0001976)1.98192647
133Neoplasm of striated muscle (HP:0009728)1.97673764
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.97380938
135Hypopigmentation of the fundus (HP:0007894)1.96439017
136Freckling (HP:0001480)1.95652221
137Small intestinal stenosis (HP:0012848)1.94226297
138Duodenal stenosis (HP:0100867)1.94226297
139Megaloblastic anemia (HP:0001889)1.93764190
140Hepatocellular necrosis (HP:0001404)1.92909657
14111 pairs of ribs (HP:0000878)1.92773003
142CNS hypomyelination (HP:0003429)1.92304943
143Missing ribs (HP:0000921)1.91961128
144Neoplasm of the colon (HP:0100273)1.91585553
145Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91402431
146Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91402431
147Acute encephalopathy (HP:0006846)1.90846663
148Glossoptosis (HP:0000162)1.90786595
149Long clavicles (HP:0000890)1.90749911
150Irregular epiphyses (HP:0010582)1.90663331
151Abnormalities of placenta or umbilical cord (HP:0001194)1.90214936
152Sparse eyelashes (HP:0000653)1.89786975
153Ocular albinism (HP:0001107)1.89658879
154Neoplasm of the adrenal gland (HP:0100631)1.89508656
155Opisthotonus (HP:0002179)1.89333763
156Embryonal renal neoplasm (HP:0011794)1.88269599
157Gonadotropin excess (HP:0000837)1.87385832
158Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86105308
159Hepatic necrosis (HP:0002605)1.85787152
160Abnormality of the musculature of the pelvis (HP:0001469)1.84000896
161Abnormality of the hip-girdle musculature (HP:0001445)1.84000896
162Amaurosis fugax (HP:0100576)1.83524065
163Melanoma (HP:0002861)1.83460871
164Microretrognathia (HP:0000308)1.83424829
165Conjunctival telangiectasia (HP:0000524)1.83029217
166Abnormality of placental membranes (HP:0011409)1.83021459
167Amniotic constriction ring (HP:0009775)1.83021459
168Abnormality of pyrimidine metabolism (HP:0004353)1.82769557
169Abnormal cartilage morphology (HP:0002763)1.82746991
170Aplasia/Hypoplasia of the macula (HP:0008059)1.82608094
171Atresia of the external auditory canal (HP:0000413)1.82043332
172Breast aplasia (HP:0100783)1.81919110
173Macrocytic anemia (HP:0001972)1.81337148
174Abnormality of the vasculature of the conjunctiva (HP:0008054)1.80591714
175Overlapping toe (HP:0001845)1.80289401
176Autoimmune hemolytic anemia (HP:0001890)1.79387839
177Abdominal situs inversus (HP:0003363)1.79225147
178Abnormality of abdominal situs (HP:0011620)1.79225147

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.44169129
2BUB13.55686036
3CDC73.42873742
4EIF2AK13.19540576
5NEK22.83726485
6MST42.80989284
7TTK2.45365889
8PDK42.42088745
9PDK32.42088745
10BMPR1B2.40375507
11EPHA22.33341812
12NEK12.29576374
13BRSK22.23175127
14TRIM282.18687634
15EIF2AK32.07439750
16PLK42.07095551
17SCYL22.05563096
18TSSK62.03787782
19PKN21.98989089
20SRPK11.92816149
21ERBB31.88802085
22TESK21.86947387
23PLK11.81017687
24MAP3K121.76205353
25ACVR1B1.75910041
26RPS6KB21.74221874
27CDK121.73394451
28PDK21.66810722
29RPS6KA41.61335691
30PNCK1.58257849
31MAP3K81.55689896
32PLK31.53353160
33TAF11.52314500
34AURKB1.48466122
35NME21.48142057
36DYRK31.43138877
37LATS11.41844583
38CHEK21.41818993
39ATR1.41502555
40STK31.40768098
41CDK71.37273164
42STK101.37057591
43BCR1.33163887
44TESK11.33046049
45CHEK11.23517881
46PASK1.22441792
47EEF2K1.17204624
48TLK11.16971762
49PLK21.14846241
50CDK81.13760462
51AURKA1.13233612
52CDK41.13006999
53CSNK1A1L1.08378565
54CSNK1G31.05989705
55CSNK1G11.05847462
56VRK21.05156623
57PBK1.04810964
58PAK41.00901184
59STK41.00567030
60FRK0.95764336
61CSNK1G20.94712393
62PIM10.94612542
63ZAK0.94610717
64MYLK0.93028869
65TRIB30.88671594
66BRSK10.87395303
67ATM0.86817230
68MAP4K20.84534690
69SIK30.84488982
70FLT30.82149019
71ALK0.81252898
72MARK30.80332742
73TGFBR10.79219056
74MET0.77783645
75LATS20.77311789
76CDK20.76688288
77CDK60.76297681
78CAMKK20.74651120
79IRAK30.72032959
80MST1R0.71919038
81STK390.70970293
82MKNK10.68475487
83LRRK20.66673551
84VRK10.66175388
85MAP2K30.65471636
86PAK10.64767365
87MTOR0.64422439
88FER0.64278228
89MAP2K70.63276197
90PIK3CG0.61592481
91CSNK2A20.59962971
92AKT30.59450020
93STK38L0.59131469
94CDK10.55545862
95BRAF0.55292990
96NEK90.53987131
97BMPR20.53205627
98BRD40.51970081
99TRPM70.50692090
100MELK0.50244907
101GRK70.49718347
102TEC0.48666017
103JAK30.47597324
104BMX0.46945493
105CSNK2A10.45874194
106MAP3K40.45370212
107RPS6KA50.44896495
108CLK10.43226845
109CSNK1E0.43090842
110PRKCI0.42945187
111NEK60.42628412
112PAK20.41573724
113RAF10.40328177
114TTN0.39892274
115MAP3K30.39163989
116MAP3K50.39085443
117PIM20.38413904
118CDK90.36708269
119CSNK1D0.35823482
120KSR10.35347832
121MUSK0.33676587
122DAPK10.33067766
123EIF2AK20.32983162
124NUAK10.32479807
125ILK0.32034275
126DDR20.31276590
127WNK30.30695731
128JAK10.30311457
129MAP4K10.30245831
130PRKDC0.29679718
131MKNK20.27797278
132TYRO30.27731762
133AKT20.27677499
134CCNB10.26456653
135ABL20.25220305
136FGFR10.23636337
137MAPKAPK30.22401674
138LIMK10.21819667
139STK160.21808530
140ERBB40.20251224
141MAP3K100.19004454

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.97841428
2DNA replication_Homo sapiens_hsa030303.95063889
3Mismatch repair_Homo sapiens_hsa034303.55034408
4RNA transport_Homo sapiens_hsa030133.51773706
5One carbon pool by folate_Homo sapiens_hsa006703.00491195
6Protein export_Homo sapiens_hsa030602.91741793
7Proteasome_Homo sapiens_hsa030502.91250788
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.88263555
9Spliceosome_Homo sapiens_hsa030402.82767784
10RNA polymerase_Homo sapiens_hsa030202.71909861
11Cell cycle_Homo sapiens_hsa041102.71176641
12Vitamin B6 metabolism_Homo sapiens_hsa007502.51812666
13* Nucleotide excision repair_Homo sapiens_hsa034202.34032636
14Homologous recombination_Homo sapiens_hsa034402.23884272
15Base excision repair_Homo sapiens_hsa034102.17306674
16Ribosome_Homo sapiens_hsa030102.07634768
17Pyrimidine metabolism_Homo sapiens_hsa002402.01061311
18Fanconi anemia pathway_Homo sapiens_hsa034601.91724667
19Fatty acid elongation_Homo sapiens_hsa000621.84470302
20p53 signaling pathway_Homo sapiens_hsa041151.80586843
21mRNA surveillance pathway_Homo sapiens_hsa030151.72947749
22RNA degradation_Homo sapiens_hsa030181.68943436
23Sulfur metabolism_Homo sapiens_hsa009201.65584350
24Selenocompound metabolism_Homo sapiens_hsa004501.63554071
25* Basal transcription factors_Homo sapiens_hsa030221.63482108
26Non-homologous end-joining_Homo sapiens_hsa034501.57084240
27Systemic lupus erythematosus_Homo sapiens_hsa053221.51524217
28Pentose phosphate pathway_Homo sapiens_hsa000301.49455793
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45175121
30Biosynthesis of amino acids_Homo sapiens_hsa012301.39694123
31Propanoate metabolism_Homo sapiens_hsa006401.37856755
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.28113858
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24505318
34Epstein-Barr virus infection_Homo sapiens_hsa051691.22959137
35Antigen processing and presentation_Homo sapiens_hsa046121.20603438
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19755214
37Folate biosynthesis_Homo sapiens_hsa007901.18940165
38* Viral carcinogenesis_Homo sapiens_hsa052031.15736485
39Steroid biosynthesis_Homo sapiens_hsa001001.15631300
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.12423319
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09100400
42Oocyte meiosis_Homo sapiens_hsa041141.08228145
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01942400
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00267143
45Purine metabolism_Homo sapiens_hsa002300.98599448
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97878667
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95333579
48Carbon metabolism_Homo sapiens_hsa012000.90425685
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86975671
50Oxidative phosphorylation_Homo sapiens_hsa001900.86930771
51Legionellosis_Homo sapiens_hsa051340.86136964
52Parkinsons disease_Homo sapiens_hsa050120.85195431
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83220831
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82008336
55Small cell lung cancer_Homo sapiens_hsa052220.79400144
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79174625
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75558277
58Herpes simplex infection_Homo sapiens_hsa051680.72586033
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70798472
60MicroRNAs in cancer_Homo sapiens_hsa052060.70422408
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69999355
62Glutathione metabolism_Homo sapiens_hsa004800.69098917
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.68956318
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68931942
65Huntingtons disease_Homo sapiens_hsa050160.68303615
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67678977
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65338050
68Sphingolipid metabolism_Homo sapiens_hsa006000.64416248
69Fructose and mannose metabolism_Homo sapiens_hsa000510.63921805
70Vibrio cholerae infection_Homo sapiens_hsa051100.62387892
71Circadian rhythm_Homo sapiens_hsa047100.61901243
72mTOR signaling pathway_Homo sapiens_hsa041500.60630840
73HTLV-I infection_Homo sapiens_hsa051660.58516633
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57221365
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55901014
76Apoptosis_Homo sapiens_hsa042100.54979823
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.54184366
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52773075
79Fatty acid metabolism_Homo sapiens_hsa012120.52327241
80Butanoate metabolism_Homo sapiens_hsa006500.51192752
81Collecting duct acid secretion_Homo sapiens_hsa049660.50118886
82Thyroid cancer_Homo sapiens_hsa052160.47230482
83Shigellosis_Homo sapiens_hsa051310.47089778
84HIF-1 signaling pathway_Homo sapiens_hsa040660.45193457
85Sulfur relay system_Homo sapiens_hsa041220.44860017
86Lysosome_Homo sapiens_hsa041420.42819383
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42135657
88Caffeine metabolism_Homo sapiens_hsa002320.40487134
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40252134
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40105651
91Peroxisome_Homo sapiens_hsa041460.39127183
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38254154
93Pyruvate metabolism_Homo sapiens_hsa006200.38131196
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36771358
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36459996
96TGF-beta signaling pathway_Homo sapiens_hsa043500.35339051
97Galactose metabolism_Homo sapiens_hsa000520.35221726
98Hepatitis B_Homo sapiens_hsa051610.34391981
99Bladder cancer_Homo sapiens_hsa052190.33427525
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33040900
101Regulation of autophagy_Homo sapiens_hsa041400.32699964
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32340731
103Measles_Homo sapiens_hsa051620.32092947
104Prostate cancer_Homo sapiens_hsa052150.32029367
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29685171
106Fatty acid degradation_Homo sapiens_hsa000710.29547302
107Hippo signaling pathway_Homo sapiens_hsa043900.28571346
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.28450041
109Alcoholism_Homo sapiens_hsa050340.26910683
110Alzheimers disease_Homo sapiens_hsa050100.26525330
111Proteoglycans in cancer_Homo sapiens_hsa052050.26270828
112Adherens junction_Homo sapiens_hsa045200.25370489
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.25229505
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25211280
115Chronic myeloid leukemia_Homo sapiens_hsa052200.25167922
116Vitamin digestion and absorption_Homo sapiens_hsa049770.25066369
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.23722279
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23608001
119Renin-angiotensin system_Homo sapiens_hsa046140.23155006
120Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21264249
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.21117794
122Influenza A_Homo sapiens_hsa051640.20840217
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20258178
124N-Glycan biosynthesis_Homo sapiens_hsa005100.19960359
125Fat digestion and absorption_Homo sapiens_hsa049750.19727261
126Tight junction_Homo sapiens_hsa045300.18665742
127Lysine degradation_Homo sapiens_hsa003100.18033677
128Metabolic pathways_Homo sapiens_hsa011000.17474659
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16249224
130Colorectal cancer_Homo sapiens_hsa052100.15726236
131FoxO signaling pathway_Homo sapiens_hsa040680.13466139
132Acute myeloid leukemia_Homo sapiens_hsa052210.12457669
133AMPK signaling pathway_Homo sapiens_hsa041520.11155094
134Arginine and proline metabolism_Homo sapiens_hsa003300.11115863
135Linoleic acid metabolism_Homo sapiens_hsa005910.10905004
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.10093357

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