GTF2H2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.38714285
2CENP-A containing nucleosome assembly (GO:0034080)4.04632570
3mitotic metaphase plate congression (GO:0007080)4.03721175
4chromatin remodeling at centromere (GO:0031055)3.91679993
5DNA double-strand break processing (GO:0000729)3.91589507
6DNA deamination (GO:0045006)3.85427384
7DNA replication checkpoint (GO:0000076)3.83389085
8termination of RNA polymerase III transcription (GO:0006386)3.78275630
9transcription elongation from RNA polymerase III promoter (GO:0006385)3.78275630
10kinetochore organization (GO:0051383)3.76824443
11kinetochore assembly (GO:0051382)3.73922394
12purine nucleobase biosynthetic process (GO:0009113)3.67880194
13behavioral response to nicotine (GO:0035095)3.66494701
14DNA replication initiation (GO:0006270)3.60214614
15replication fork processing (GO:0031297)3.57042216
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.53785739
17metaphase plate congression (GO:0051310)3.53379752
18water-soluble vitamin biosynthetic process (GO:0042364)3.47063558
19ribosomal large subunit biogenesis (GO:0042273)3.45543235
20ribosome assembly (GO:0042255)3.44452909
21spliceosomal snRNP assembly (GO:0000387)3.44434178
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.42603360
23NADH dehydrogenase complex assembly (GO:0010257)3.42603360
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42603360
25* transcription elongation from RNA polymerase I promoter (GO:0006362)3.40618912
26nucleobase biosynthetic process (GO:0046112)3.39903981
27attachment of spindle microtubules to kinetochore (GO:0008608)3.38870463
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37398547
29somatic hypermutation of immunoglobulin genes (GO:0016446)3.37398547
30maturation of 5.8S rRNA (GO:0000460)3.37326667
31telomere maintenance via semi-conservative replication (GO:0032201)3.37193722
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35809437
33maturation of SSU-rRNA (GO:0030490)3.34962968
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34436733
35DNA strand elongation involved in DNA replication (GO:0006271)3.33003939
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32837883
37rRNA modification (GO:0000154)3.32393401
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.31870256
39ATP synthesis coupled proton transport (GO:0015986)3.31870256
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30970308
41DNA replication-independent nucleosome organization (GO:0034724)3.30258959
42DNA replication-independent nucleosome assembly (GO:0006336)3.30258959
43negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.29168568
44negative regulation of translation, ncRNA-mediated (GO:0040033)3.29168568
45regulation of translation, ncRNA-mediated (GO:0045974)3.29168568
46pseudouridine synthesis (GO:0001522)3.27942199
47ribosome biogenesis (GO:0042254)3.27707599
48* termination of RNA polymerase I transcription (GO:0006363)3.27330172
49respiratory chain complex IV assembly (GO:0008535)3.26649599
50mitochondrial respiratory chain complex assembly (GO:0033108)3.26106765
51* RNA capping (GO:0036260)3.25376238
52* 7-methylguanosine RNA capping (GO:0009452)3.25376238
53histone exchange (GO:0043486)3.25310567
54spindle checkpoint (GO:0031577)3.23864455
55ribonucleoprotein complex biogenesis (GO:0022613)3.22450011
56DNA strand elongation (GO:0022616)3.21556548
57* 7-methylguanosine mRNA capping (GO:0006370)3.19520876
58GTP biosynthetic process (GO:0006183)3.19512337
59protein complex biogenesis (GO:0070271)3.16027190
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14813142
61rRNA processing (GO:0006364)3.14540583
62telomere maintenance via recombination (GO:0000722)3.14256478
63regulation of double-strand break repair via homologous recombination (GO:0010569)3.13741725
64synapsis (GO:0007129)3.12324805
65histone H2A acetylation (GO:0043968)3.11934657
66recombinational repair (GO:0000725)3.09137063
67double-strand break repair via homologous recombination (GO:0000724)3.08065799
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07537047
69telomere maintenance via telomere lengthening (GO:0010833)3.07501583
70* transcription-coupled nucleotide-excision repair (GO:0006283)3.07453829
71negative regulation of ligase activity (GO:0051352)3.07387606
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07387606
73guanosine-containing compound biosynthetic process (GO:1901070)3.07011214
74mitotic spindle checkpoint (GO:0071174)3.06511187
75DNA replication-dependent nucleosome organization (GO:0034723)3.06395804
76DNA replication-dependent nucleosome assembly (GO:0006335)3.06395804
77negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05985037
78negative regulation of sister chromatid segregation (GO:0033046)3.05985037
79negative regulation of mitotic sister chromatid separation (GO:2000816)3.05985037
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05985037
81rRNA metabolic process (GO:0016072)3.04137772
82regulation of nuclear cell cycle DNA replication (GO:0033262)3.02289336
83mitotic recombination (GO:0006312)3.02119336
84negative regulation of chromosome segregation (GO:0051985)3.01822724
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01000145
86spindle assembly checkpoint (GO:0071173)3.00667108
87mitotic spindle assembly checkpoint (GO:0007094)3.00555790
88* transcription from RNA polymerase I promoter (GO:0006360)2.98831666
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98321015
90regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97573752
91regulation of mitotic spindle checkpoint (GO:1903504)2.97573752
92establishment of chromosome localization (GO:0051303)2.97047080
93meiotic chromosome segregation (GO:0045132)2.96757685
94DNA ligation (GO:0006266)2.95936590
95regulation of DNA endoreduplication (GO:0032875)2.95360867
96mitochondrial RNA metabolic process (GO:0000959)2.95249802
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.94342278
98spliceosomal complex assembly (GO:0000245)2.93425430
99regulation of gene silencing by RNA (GO:0060966)2.93121092
100regulation of posttranscriptional gene silencing (GO:0060147)2.93121092
101regulation of gene silencing by miRNA (GO:0060964)2.93121092
102rRNA methylation (GO:0031167)2.92262604
103maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91269854
104protein K6-linked ubiquitination (GO:0085020)2.88304604
105peptidyl-histidine modification (GO:0018202)2.88134640
106UTP biosynthetic process (GO:0006228)2.87761616
107microtubule depolymerization (GO:0007019)2.87364150
108DNA catabolic process, exonucleolytic (GO:0000738)2.87011784
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86789411
110establishment of integrated proviral latency (GO:0075713)2.85095662
111regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84507779
112telomere maintenance via telomerase (GO:0007004)2.84022563
113RNA-dependent DNA replication (GO:0006278)2.83787931
114RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83665392
115viral mRNA export from host cell nucleus (GO:0046784)2.83535358
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.81143936
117chaperone-mediated protein transport (GO:0072321)2.79772267
118cullin deneddylation (GO:0010388)2.79410609
119establishment of protein localization to mitochondrial membrane (GO:0090151)2.79403578
120DNA damage response, detection of DNA damage (GO:0042769)2.78299397
121tRNA processing (GO:0008033)2.77887084
122* transcription initiation from RNA polymerase I promoter (GO:0006361)2.77849370
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.77239926
124cytochrome complex assembly (GO:0017004)2.77040977
125nucleotide-excision repair, DNA gap filling (GO:0006297)2.76799495
126cellular component biogenesis (GO:0044085)2.76075503
127L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74613929
128DNA-dependent DNA replication (GO:0006261)2.74521162
129histone mRNA metabolic process (GO:0008334)2.74061566
130reciprocal meiotic recombination (GO:0007131)2.74042698
131reciprocal DNA recombination (GO:0035825)2.74042698
132regulation of sister chromatid segregation (GO:0033045)2.73714548
133regulation of mitotic sister chromatid separation (GO:0010965)2.73714548
134regulation of mitotic sister chromatid segregation (GO:0033047)2.73714548
135G1/S transition of mitotic cell cycle (GO:0000082)2.73457500
136cell cycle G1/S phase transition (GO:0044843)2.73457500
137* DNA-templated transcription, elongation (GO:0006354)2.73393075
138tRNA methylation (GO:0030488)2.73197934
139ribosomal small subunit biogenesis (GO:0042274)2.72723547
140ribosomal small subunit assembly (GO:0000028)2.70411397
141regulation of centriole replication (GO:0046599)2.70392065
142replicative senescence (GO:0090399)2.66509333
143mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.66345139
144protein-cofactor linkage (GO:0018065)2.65593560
145resolution of meiotic recombination intermediates (GO:0000712)2.64903444
146ncRNA catabolic process (GO:0034661)2.63146771
147DNA strand renaturation (GO:0000733)2.62267905
148IMP biosynthetic process (GO:0006188)2.60866533
149nonmotile primary cilium assembly (GO:0035058)2.58232503
150regulation of centrosome cycle (GO:0046605)2.56399600
151somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.54972068
152isotype switching (GO:0045190)2.54972068
153somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.54972068
154regulation of mitochondrial translation (GO:0070129)2.54752168
155tRNA metabolic process (GO:0006399)2.52825188
156histone-serine phosphorylation (GO:0035404)2.52134133
157L-serine metabolic process (GO:0006563)2.49281764
158ncRNA processing (GO:0034470)2.48201209
159kidney morphogenesis (GO:0060993)2.48024536
160folic acid-containing compound biosynthetic process (GO:0009396)2.47764036
161ncRNA metabolic process (GO:0034660)2.46208343
162rRNA catabolic process (GO:0016075)2.45930526
163somatic diversification of immunoglobulins (GO:0016445)2.44667283
164postreplication repair (GO:0006301)2.43990421
165somatic recombination of immunoglobulin gene segments (GO:0016447)2.43510536
166DNA recombination (GO:0006310)2.42788853
167intracellular protein transmembrane import (GO:0044743)2.41652166

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.20368315
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.27246092
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.81356713
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.59656835
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58495705
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.53498138
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.35487238
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33585753
9ZNF274_21170338_ChIP-Seq_K562_Hela3.19962865
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03656171
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.99051769
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.81969001
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.78985588
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.75437382
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.71317921
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.65519422
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62572006
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61618054
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61296682
20VDR_23849224_ChIP-Seq_CD4+_Human2.56253894
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55132155
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48885663
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48368542
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44048710
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40497423
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29677416
27IGF1R_20145208_ChIP-Seq_DFB_Human2.24289603
28ELK1_19687146_ChIP-ChIP_HELA_Human2.09019760
29FOXP3_21729870_ChIP-Seq_TREG_Human2.07564929
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07550930
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.05030921
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99050782
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.98055446
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97613612
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94635025
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92148173
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.90505120
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.90243090
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.89355593
40DCP1A_22483619_ChIP-Seq_HELA_Human1.86788793
41TAF15_26573619_Chip-Seq_HEK293_Human1.86568519
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83916968
43TTF2_22483619_ChIP-Seq_HELA_Human1.81790796
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81759276
45* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80668735
46EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77296846
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73346603
48XRN2_22483619_ChIP-Seq_HELA_Human1.70266786
49* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67500713
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64125762
51P300_19829295_ChIP-Seq_ESCs_Human1.63273579
52AR_21909140_ChIP-Seq_LNCAP_Human1.61606616
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.61307922
54GABP_19822575_ChIP-Seq_HepG2_Human1.60634633
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.56961698
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56955481
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56433496
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56040189
59* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52963704
60ER_23166858_ChIP-Seq_MCF-7_Human1.51260095
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49557653
62EWS_26573619_Chip-Seq_HEK293_Human1.49207146
63FUS_26573619_Chip-Seq_HEK293_Human1.48038881
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46633921
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.43787867
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41910805
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41829927
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40029863
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37703599
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37494622
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37414022
72IRF1_19129219_ChIP-ChIP_H3396_Human1.36342630
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32655548
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.31415446
75MYC_18940864_ChIP-ChIP_HL60_Human1.24767020
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24276125
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22999335
78TP53_22573176_ChIP-Seq_HFKS_Human1.20589524
79CIITA_25753668_ChIP-Seq_RAJI_Human1.20553833
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.17670611
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17145804
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11767716
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11317115
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10358256
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09321738
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09136381
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07606626
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07131772
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04694258
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.03757504
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02850002
92AR_21572438_ChIP-Seq_LNCaP_Human1.02376623
93KDM5A_27292631_Chip-Seq_BREAST_Human1.02125587
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01993760
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01763673
96STAT3_23295773_ChIP-Seq_U87_Human1.01058478
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.98059183
98CBP_20019798_ChIP-Seq_JUKART_Human0.96651522
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96651522
100POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96040494
101CBX2_27304074_Chip-Seq_ESCs_Mouse0.95323424
102SOX2_19829295_ChIP-Seq_ESCs_Human0.94866091
103NANOG_19829295_ChIP-Seq_ESCs_Human0.94866091
104FOXA1_25329375_ChIP-Seq_VCAP_Human0.93377977
105FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93377977
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93222984
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93178265
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92180971
109SALL1_21062744_ChIP-ChIP_HESCs_Human0.91348935
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91310998
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91310998
112BCAT_22108803_ChIP-Seq_LS180_Human0.91158855
113TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91091670
114* NANOG_16153702_ChIP-ChIP_HESCs_Human0.90735363
115TCF4_22108803_ChIP-Seq_LS180_Human0.88955345
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88867476
117SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88498388
118TCF4_23295773_ChIP-Seq_U87_Human0.87474610
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83431678
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82615108
121GBX2_23144817_ChIP-Seq_PC3_Human0.79529033
122BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79315876
123RNF2_27304074_Chip-Seq_NSC_Mouse0.77648222
124VDR_22108803_ChIP-Seq_LS180_Human0.77288470
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.77115048
126GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77009439
127SOX17_20123909_ChIP-Seq_XEN_Mouse0.75919731
128KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75702612
129EZH2_27294783_Chip-Seq_NPCs_Mouse0.75514974
130NMYC_18555785_Chip-Seq_ESCs_Mouse0.75077111
131ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74771144
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.72921683
133SPI1_23547873_ChIP-Seq_NB4_Human0.71842519
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.71740822
135EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.71144179
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.70880198
137BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.70667311
138FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.70263387
139SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.69357418

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.57182743
2MP0006292_abnormal_olfactory_placode4.25840794
3MP0010094_abnormal_chromosome_stability3.93559366
4MP0008058_abnormal_DNA_repair3.75993312
5MP0008057_abnormal_DNA_replication3.66795490
6MP0003111_abnormal_nucleus_morphology3.59430109
7MP0008877_abnormal_DNA_methylation3.31149715
8MP0003077_abnormal_cell_cycle3.00965271
9MP0004957_abnormal_blastocyst_morpholog2.95097735
10MP0003718_maternal_effect2.72981393
11MP0008932_abnormal_embryonic_tissue2.51121170
12MP0001188_hyperpigmentation2.48708916
13MP0003890_abnormal_embryonic-extraembry2.44921475
14MP0008007_abnormal_cellular_replicative2.44462431
15MP0002396_abnormal_hematopoietic_system2.42418483
16MP0003123_paternal_imprinting2.30700787
17MP0003136_yellow_coat_color2.14214621
18MP0000569_abnormal_digit_pigmentation2.09044166
19MP0003786_premature_aging1.92175923
20MP0003195_calcinosis1.91867732
21MP0005551_abnormal_eye_electrophysiolog1.88784112
22MP0003121_genomic_imprinting1.77988223
23MP0001986_abnormal_taste_sensitivity1.77752640
24MP0002102_abnormal_ear_morphology1.71827472
25MP0009697_abnormal_copulation1.59926739
26MP0008260_abnormal_autophagy1.50310492
27MP0002210_abnormal_sex_determination1.49470551
28MP0005253_abnormal_eye_physiology1.47687715
29MP0005171_absent_coat_pigmentation1.46833657
30MP0003567_abnormal_fetal_cardiomyocyte1.46711178
31MP0003938_abnormal_ear_development1.44748781
32MP0002009_preneoplasia1.43721362
33MP0003787_abnormal_imprinting1.43225723
34MP0000631_abnormal_neuroendocrine_gland1.40222572
35MP0005409_darkened_coat_color1.35220820
36MP0003315_abnormal_perineum_morphology1.34763769
37MP0003941_abnormal_skin_development1.32467681
38MP0002160_abnormal_reproductive_system1.30810752
39MP0002638_abnormal_pupillary_reflex1.29425700
40MP0001145_abnormal_male_reproductive1.20591488
41MP0002163_abnormal_gland_morphology1.20539292
42MP0005187_abnormal_penis_morphology1.18199475
43MP0002837_dystrophic_cardiac_calcinosis1.17954506
44MP0001529_abnormal_vocalization1.17112206
45MP0005389_reproductive_system_phenotype1.16995391
46MP0000383_abnormal_hair_follicle1.16776397
47MP0000566_synostosis1.15785931
48MP0001905_abnormal_dopamine_level1.15725371
49MP0001929_abnormal_gametogenesis1.15674720
50MP0002132_abnormal_respiratory_system1.13433301
51MP0002234_abnormal_pharynx_morphology1.13184915
52MP0000350_abnormal_cell_proliferation1.12178264
53MP0004043_abnormal_pH_regulation1.11559801
54MP0000427_abnormal_hair_cycle1.11520366
55MP0005084_abnormal_gallbladder_morpholo1.11242210
56MP0000653_abnormal_sex_gland1.10236729
57MP0000015_abnormal_ear_pigmentation1.10019957
58MP0002095_abnormal_skin_pigmentation1.07904878
59MP0002938_white_spotting1.05846331
60MP0000372_irregular_coat_pigmentation1.03861019
61MP0001919_abnormal_reproductive_system1.02798898
62MP0005671_abnormal_response_to1.02645854
63MP0000490_abnormal_crypts_of1.02039596
64MP0006035_abnormal_mitochondrial_morpho1.01245432
65MP0005645_abnormal_hypothalamus_physiol1.00682870
66MP0003119_abnormal_digestive_system1.00292950
67MP0003646_muscle_fatigue0.99948132
68MP0002277_abnormal_respiratory_mucosa0.99643875
69MP0009379_abnormal_foot_pigmentation0.98798374
70MP0000313_abnormal_cell_death0.97711176
71MP0004142_abnormal_muscle_tone0.96965647
72MP0004147_increased_porphyrin_level0.96864069
73MP0005379_endocrine/exocrine_gland_phen0.96584714
74MP0000647_abnormal_sebaceous_gland0.95345995
75MP0004145_abnormal_muscle_electrophysio0.94515792
76MP0001119_abnormal_female_reproductive0.94283398
77MP0005646_abnormal_pituitary_gland0.94227680
78MP0001730_embryonic_growth_arrest0.94080212
79MP0009046_muscle_twitch0.92660980
80MP0001968_abnormal_touch/_nociception0.92021229
81MP0002084_abnormal_developmental_patter0.91834186
82MP0009745_abnormal_behavioral_response0.91651056
83MP0001485_abnormal_pinna_reflex0.90098247
84MP0000026_abnormal_inner_ear0.88649951
85MP0009333_abnormal_splenocyte_physiolog0.88631832
86MP0003937_abnormal_limbs/digits/tail_de0.87486954
87MP0008872_abnormal_physiological_respon0.87401182
88MP0005391_vision/eye_phenotype0.86219563
89MP0004381_abnormal_hair_follicle0.86044399
90MP0001324_abnormal_eye_pigmentation0.85966340
91MP0001963_abnormal_hearing_physiology0.85888823
92MP0003698_abnormal_male_reproductive0.85579999
93MP0005075_abnormal_melanosome_morpholog0.84090880
94MP0005380_embryogenesis_phenotype0.83912800
95MP0001672_abnormal_embryogenesis/_devel0.83912800
96MP0004885_abnormal_endolymph0.83621021
97MP0005195_abnormal_posterior_eye0.81494885
98MP0004808_abnormal_hematopoietic_stem0.81487120
99MP0002928_abnormal_bile_duct0.80635616
100MP0003122_maternal_imprinting0.80613116
101MP0003011_delayed_dark_adaptation0.80417940
102MP0002272_abnormal_nervous_system0.79000396
103MP0006072_abnormal_retinal_apoptosis0.78948435
104MP0002752_abnormal_somatic_nervous0.78683152
105MP0006276_abnormal_autonomic_nervous0.77294095
106MP0001697_abnormal_embryo_size0.76918559
107MP0000689_abnormal_spleen_morphology0.76625407
108MP0008961_abnormal_basal_metabolism0.75522176
109MP0002557_abnormal_social/conspecific_i0.75085455
110MP0000703_abnormal_thymus_morphology0.74952501
111MP0002736_abnormal_nociception_after0.74696164
112MP0003936_abnormal_reproductive_system0.72940634
113MP0006036_abnormal_mitochondrial_physio0.72851465
114MP0001286_abnormal_eye_development0.72450889
115MP0000778_abnormal_nervous_system0.71795019
116MP0003861_abnormal_nervous_system0.71701705
117MP0003763_abnormal_thymus_physiology0.71639804
118MP0001764_abnormal_homeostasis0.71433369
119MP0004742_abnormal_vestibular_system0.71001017
120MP0002722_abnormal_immune_system0.70793805
121MP0008004_abnormal_stomach_pH0.70172706
122MP0002085_abnormal_embryonic_tissue0.69589900
123MP0002398_abnormal_bone_marrow0.68033140
124MP0003880_abnormal_central_pattern0.66110435
125MP0002751_abnormal_autonomic_nervous0.66071598
126MP0003984_embryonic_growth_retardation0.65416913
127MP0005174_abnormal_tail_pigmentation0.64493336
128MP0001486_abnormal_startle_reflex0.64308377
129MP0002080_prenatal_lethality0.63707513
130MP0002019_abnormal_tumor_incidence0.63251054
131MP0002088_abnormal_embryonic_growth/wei0.62036295
132MP0001293_anophthalmia0.62005459
133MP0001727_abnormal_embryo_implantation0.61983278
134MP0005451_abnormal_body_composition0.61195392
135MP0005395_other_phenotype0.60132546
136MP0001853_heart_inflammation0.59920553
137MP0001545_abnormal_hematopoietic_system0.59683471
138MP0005397_hematopoietic_system_phenotyp0.59683471
139MP0000049_abnormal_middle_ear0.58082627
140MP0004133_heterotaxia0.57247101
141MP0008995_early_reproductive_senescence0.55515665

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.85596139
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.33293329
3Chromsome breakage (HP:0040012)4.33181318
4Abnormality of the preputium (HP:0100587)3.31021541
5Meckel diverticulum (HP:0002245)3.24874570
6Breast hypoplasia (HP:0003187)3.23956758
7Congenital stationary night blindness (HP:0007642)3.16129123
8Abnormality of chromosome stability (HP:0003220)3.12570584
9Reticulocytopenia (HP:0001896)3.05284970
10Abnormality of the ileum (HP:0001549)3.03730686
11Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.93929599
12Abnormality of alanine metabolism (HP:0010916)2.93929599
13Hyperalaninemia (HP:0003348)2.93929599
14Abnormality of DNA repair (HP:0003254)2.93882084
15Colon cancer (HP:0003003)2.91515743
16Duplicated collecting system (HP:0000081)2.89774916
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.88169299
18Rough bone trabeculation (HP:0100670)2.82838424
19Abnormality of the pons (HP:0007361)2.82305973
20Nephronophthisis (HP:0000090)2.78292552
21Patellar aplasia (HP:0006443)2.75636579
22Cerebral hypomyelination (HP:0006808)2.68405164
23Abnormality of the renal cortex (HP:0011035)2.67332437
24Bone marrow hypocellularity (HP:0005528)2.65106158
25Abnormal respiratory epithelium morphology (HP:0012253)2.64513108
26Abnormal respiratory motile cilium morphology (HP:0005938)2.64513108
27Type II lissencephaly (HP:0007260)2.62628709
28Aplasia/Hypoplasia of the patella (HP:0006498)2.57822960
29Hypoplasia of the pons (HP:0012110)2.56689408
30Abnormality of the renal collecting system (HP:0004742)2.54143944
31Supernumerary spleens (HP:0009799)2.53502301
32Small intestinal stenosis (HP:0012848)2.51868768
33Duodenal stenosis (HP:0100867)2.51868768
34Renal cortical cysts (HP:0000803)2.50153299
35Microvesicular hepatic steatosis (HP:0001414)2.50087439
36Abnormal ciliary motility (HP:0012262)2.46876109
373-Methylglutaconic aciduria (HP:0003535)2.46270270
38Pancreatic fibrosis (HP:0100732)2.42998972
39Abnormal number of incisors (HP:0011064)2.42379976
40Triphalangeal thumb (HP:0001199)2.40129115
41Abnormality of the renal medulla (HP:0100957)2.39315262
42Medial flaring of the eyebrow (HP:0010747)2.36688148
43Type I transferrin isoform profile (HP:0003642)2.35680574
44Acute encephalopathy (HP:0006846)2.33161602
45Abnormal trabecular bone morphology (HP:0100671)2.33022698
46Median cleft lip (HP:0000161)2.32386708
47Clubbing of toes (HP:0100760)2.32186587
48Absent radius (HP:0003974)2.31391080
49Absent thumb (HP:0009777)2.30771449
50Premature graying of hair (HP:0002216)2.29494510
51Abnormal lung lobation (HP:0002101)2.29463182
52Abnormality of cells of the erythroid lineage (HP:0012130)2.26625047
53Lipid accumulation in hepatocytes (HP:0006561)2.26182029
54Nephroblastoma (Wilms tumor) (HP:0002667)2.25516790
55Ectopic kidney (HP:0000086)2.25341365
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.24085509
57Absent/shortened dynein arms (HP:0200106)2.24085509
58Oral leukoplakia (HP:0002745)2.22856949
59Abnormality of the labia minora (HP:0012880)2.22765332
60Adrenal hypoplasia (HP:0000835)2.22301525
61Abnormal biliary tract physiology (HP:0012439)2.21237054
62Bile duct proliferation (HP:0001408)2.21237054
63True hermaphroditism (HP:0010459)2.20014724
64Aplastic anemia (HP:0001915)2.18636045
65Agnosia (HP:0010524)2.18428560
66Aplasia involving forearm bones (HP:0009822)2.18054187
67Absent forearm bone (HP:0003953)2.18054187
68Impulsivity (HP:0100710)2.17663412
69Hyperglycinuria (HP:0003108)2.16991211
70Abnormal number of erythroid precursors (HP:0012131)2.15829348
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13098245
72Myelodysplasia (HP:0002863)2.12907334
73Horseshoe kidney (HP:0000085)2.12682230
74Submucous cleft hard palate (HP:0000176)2.11490234
75Duplication of thumb phalanx (HP:0009942)2.09821720
76Aplasia/Hypoplasia of the tibia (HP:0005772)2.09346922
77Embryonal renal neoplasm (HP:0011794)2.08818708
78Attenuation of retinal blood vessels (HP:0007843)2.08741269
79Abnormality of the duodenum (HP:0002246)2.07920130
80Pendular nystagmus (HP:0012043)2.07481028
81Sloping forehead (HP:0000340)2.07113092
82Pancreatic cysts (HP:0001737)2.05548709
83Increased hepatocellular lipid droplets (HP:0006565)2.04654311
84Methylmalonic acidemia (HP:0002912)2.01860603
85Sclerocornea (HP:0000647)2.00127918
86Concave nail (HP:0001598)1.99433768
87Lissencephaly (HP:0001339)1.99243170
88Progressive macrocephaly (HP:0004481)1.99229023
89Short tibia (HP:0005736)1.97927668
90Gait imbalance (HP:0002141)1.97468018
91Congenital primary aphakia (HP:0007707)1.97127469
92Preaxial hand polydactyly (HP:0001177)1.96060923
93Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95596338
94Abnormal spermatogenesis (HP:0008669)1.95526784
95Neoplasm of the adrenal cortex (HP:0100641)1.95317698
96Macrocytic anemia (HP:0001972)1.95226023
97Capillary hemangiomas (HP:0005306)1.94901304
98Poor coordination (HP:0002370)1.93031280
99Abnormality of homocysteine metabolism (HP:0010919)1.92997445
100Homocystinuria (HP:0002156)1.92997445
101Parakeratosis (HP:0001036)1.92818808
102Mitochondrial inheritance (HP:0001427)1.92557552
103Acute necrotizing encephalopathy (HP:0006965)1.92281753
104Anencephaly (HP:0002323)1.89726979
105Abnormal respiratory motile cilium physiology (HP:0012261)1.88917407
106Dandy-Walker malformation (HP:0001305)1.87101598
107Abnormal mitochondria in muscle tissue (HP:0008316)1.86943442
108Abnormality of glycine metabolism (HP:0010895)1.85944681
109Abnormality of serine family amino acid metabolism (HP:0010894)1.85944681
110Hyperventilation (HP:0002883)1.84494769
111Abnormality of serum amino acid levels (HP:0003112)1.83873751
112Cystic liver disease (HP:0006706)1.83639502
113Increased CSF lactate (HP:0002490)1.82910303
114Genital tract atresia (HP:0001827)1.82863622
115Inability to walk (HP:0002540)1.82246532
116Small hand (HP:0200055)1.81935305
117Glioma (HP:0009733)1.81262109
118Entropion (HP:0000621)1.80620683
119Increased serum lactate (HP:0002151)1.79840151
120Vaginal atresia (HP:0000148)1.79340782
121Progressive inability to walk (HP:0002505)1.79134848
122Furrowed tongue (HP:0000221)1.79124979
123Abolished electroretinogram (ERG) (HP:0000550)1.79005142
124Cellular immunodeficiency (HP:0005374)1.78747946
125Abnormality of the columella (HP:0009929)1.78744950
126Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78727321
127Absent epiphyses (HP:0010577)1.78635422
128Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78635422
129Nephrogenic diabetes insipidus (HP:0009806)1.78137222
130Protruding tongue (HP:0010808)1.76667491
131Pallor (HP:0000980)1.76532597
132Hyperglycinemia (HP:0002154)1.76481760
133Pancytopenia (HP:0001876)1.75533731
134Premature ovarian failure (HP:0008209)1.75206768
135Volvulus (HP:0002580)1.74857778
136Chorioretinal atrophy (HP:0000533)1.74456760
137Bilateral microphthalmos (HP:0007633)1.73674572
138Congenital, generalized hypertrichosis (HP:0004540)1.73442210
139Hypothermia (HP:0002045)1.72771443
140Gaze-evoked nystagmus (HP:0000640)1.72723740
141Hepatic necrosis (HP:0002605)1.72667326
142Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72505013
143Chronic hepatic failure (HP:0100626)1.71013729
144Large for gestational age (HP:0001520)1.70909383
145Rectal fistula (HP:0100590)1.69323254
146Rectovaginal fistula (HP:0000143)1.69323254
147Abnormality of the incisor (HP:0000676)1.68486879
148Optic disc pallor (HP:0000543)1.68300067
149Short thumb (HP:0009778)1.67648313
150Hypergonadotropic hypogonadism (HP:0000815)1.66614074
151Abnormality of the carotid arteries (HP:0005344)1.66159385
152Hypoplasia of the radius (HP:0002984)1.65245384
153Aplasia/Hypoplasia of the earlobes (HP:0009906)1.64264142
154Irregular epiphyses (HP:0010582)1.63462196
155Prolonged neonatal jaundice (HP:0006579)1.63190807
156Abnormal hair whorl (HP:0010721)1.62941890
157Molar tooth sign on MRI (HP:0002419)1.62933767
158Abnormality of midbrain morphology (HP:0002418)1.62933767
159Aganglionic megacolon (HP:0002251)1.62140352
160Oligohydramnios (HP:0001562)1.61545601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.00284836
2FRK3.76781072
3BUB13.76644143
4WEE13.26555477
5MKNK12.71261484
6SRPK12.69852555
7MKNK22.56812272
8TSSK62.46073837
9VRK12.33235678
10GRK12.29772114
11BRSK22.21366062
12WNK32.18533002
13GRK72.15211586
14EIF2AK12.11613422
15TAF12.05303850
16CASK2.04236538
17PLK42.00923388
18CDC71.90446929
19ZAK1.85469123
20EIF2AK31.84338596
21TGFBR21.81065057
22EIF2AK21.79827885
23PLK31.79069897
24WNK41.77846174
25PNCK1.72295475
26TNIK1.62939688
27CDK31.61269234
28CCNB11.51575460
29NME21.51041879
30TTK1.50416697
31PLK11.48176338
32MAP4K21.47833611
33STK391.47438027
34VRK21.43141976
35CAMK1D1.27917679
36IRAK31.27776316
37INSRR1.21484929
38ACVR1B1.20238041
39BRAF1.19059981
40CLK11.18752232
41ADRBK21.17048944
42OXSR11.16641251
43CAMK1G1.16612342
44STK38L1.16164694
45AKT31.15727451
46TLK11.12762602
47NEK61.09731936
48ATR1.09419019
49PINK11.09128597
50MAP3K41.05383260
51TGFBR11.05187145
52BRSK11.04379070
53YES11.04171638
54CHEK21.01543060
55DYRK30.99636134
56STK100.98741155
57AURKB0.98616293
58CDK80.98084009
59PAK30.93858452
60TXK0.93796005
61MAPK150.92526757
62RPS6KA50.92492079
63NME10.89045982
64CAMKK20.88846775
65TEC0.88487111
66STK30.87580057
67CDK70.87400765
68PIM20.87050159
69AURKA0.86148233
70IRAK40.85202007
71NEK20.84957328
72PRPF4B0.82252110
73TAOK30.75961104
74PBK0.74268280
75PRKD30.73358823
76NUAK10.73301916
77SIK30.72671647
78PLK20.70122325
79FGFR20.69587789
80CSNK1G30.66301329
81BMPR1B0.65961536
82CHEK10.65552779
83CSNK2A10.62030356
84TRIM280.61049433
85MAPKAPK50.61002198
86BCR0.57347640
87LYN0.57007926
88PRKCG0.56998305
89CSNK1G10.56826198
90EPHA20.56430736
91MAPK130.55529173
92TNK20.55275990
93MST40.54951096
94ATM0.54047216
95LATS10.52834557
96CSNK2A20.52475386
97RPS6KA40.52052564
98PASK0.51907099
99MAP2K70.51391210
100MARK30.50754818
101CSNK1E0.50556367
102ERBB30.49748941
103ARAF0.47773849
104NEK10.47478948
105BMPR20.47422530
106ADRBK10.47366689
107MOS0.45015787
108PRKCE0.44928210
109BLK0.44694356
110CDK40.43833771
111MAP3K120.43442741
112CDK10.43205243
113MAP2K60.42408322
114BRD40.40807417
115FGFR10.40558225
116MAP3K80.39985937
117PRKDC0.39086827
118CDK20.37350665
119PRKCI0.36340227
120STK240.36261305
121DAPK20.36061018
122PAK10.35744417
123DYRK20.33968060
124WNK10.33045645
125RPS6KB20.32006977
126CSNK1A10.31472396
127CSNK1G20.31156005
128NLK0.30728436
129MAPK70.30281309
130STK40.29063773
131PIK3CA0.28650159
132ITK0.27964728
133CSNK1A1L0.25695835
134RPS6KB10.24628397
135MELK0.24302506

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.11755293
2Proteasome_Homo sapiens_hsa030503.71494912
3DNA replication_Homo sapiens_hsa030303.65868070
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.63635227
5Mismatch repair_Homo sapiens_hsa034303.49977893
6Homologous recombination_Homo sapiens_hsa034403.43997764
7Spliceosome_Homo sapiens_hsa030403.11268362
8Ribosome_Homo sapiens_hsa030103.06886439
9Fanconi anemia pathway_Homo sapiens_hsa034602.85506796
10RNA transport_Homo sapiens_hsa030132.70945486
11Pyrimidine metabolism_Homo sapiens_hsa002402.60810473
12* Nucleotide excision repair_Homo sapiens_hsa034202.49479562
13Base excision repair_Homo sapiens_hsa034102.49051017
14Selenocompound metabolism_Homo sapiens_hsa004502.44768461
15Non-homologous end-joining_Homo sapiens_hsa034502.42340787
16Cell cycle_Homo sapiens_hsa041102.40943132
17* Basal transcription factors_Homo sapiens_hsa030222.31114128
18RNA degradation_Homo sapiens_hsa030182.04162330
19Propanoate metabolism_Homo sapiens_hsa006401.78809817
20Purine metabolism_Homo sapiens_hsa002301.74846332
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72258680
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69616600
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.63221827
24Protein export_Homo sapiens_hsa030601.58519372
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55124876
26Nitrogen metabolism_Homo sapiens_hsa009101.54121136
27Vitamin B6 metabolism_Homo sapiens_hsa007501.53572899
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47871883
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42533749
30One carbon pool by folate_Homo sapiens_hsa006701.40697955
31Butanoate metabolism_Homo sapiens_hsa006501.39800631
32Oxidative phosphorylation_Homo sapiens_hsa001901.37374321
33Huntingtons disease_Homo sapiens_hsa050161.32519503
34Parkinsons disease_Homo sapiens_hsa050121.28506230
35p53 signaling pathway_Homo sapiens_hsa041151.25268971
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24966971
37mRNA surveillance pathway_Homo sapiens_hsa030151.22171388
38Epstein-Barr virus infection_Homo sapiens_hsa051691.19273175
39Tryptophan metabolism_Homo sapiens_hsa003801.18784332
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.15281108
41Ether lipid metabolism_Homo sapiens_hsa005651.14258823
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06767363
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94182268
44Sphingolipid metabolism_Homo sapiens_hsa006000.93867231
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89438745
46Regulation of autophagy_Homo sapiens_hsa041400.88117540
47Pyruvate metabolism_Homo sapiens_hsa006200.87985623
48Arachidonic acid metabolism_Homo sapiens_hsa005900.87172119
49Other glycan degradation_Homo sapiens_hsa005110.86531328
50Oocyte meiosis_Homo sapiens_hsa041140.85757064
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81959777
52Peroxisome_Homo sapiens_hsa041460.81861862
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81202507
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80151282
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78164563
56Sulfur metabolism_Homo sapiens_hsa009200.77996725
57Primary immunodeficiency_Homo sapiens_hsa053400.72511332
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72254312
59Antigen processing and presentation_Homo sapiens_hsa046120.72053168
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71712107
61Alzheimers disease_Homo sapiens_hsa050100.71261069
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70848651
63Fatty acid biosynthesis_Homo sapiens_hsa000610.69157933
64Lysine degradation_Homo sapiens_hsa003100.66291078
65Olfactory transduction_Homo sapiens_hsa047400.66162574
66Caffeine metabolism_Homo sapiens_hsa002320.64464261
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64378042
68Steroid biosynthesis_Homo sapiens_hsa001000.64038505
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62370486
70Herpes simplex infection_Homo sapiens_hsa051680.62293233
71Systemic lupus erythematosus_Homo sapiens_hsa053220.60847527
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60404174
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58219470
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57320240
75Nicotine addiction_Homo sapiens_hsa050330.55554465
76Autoimmune thyroid disease_Homo sapiens_hsa053200.52434773
77Retinol metabolism_Homo sapiens_hsa008300.52266856
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.51365286
79Sulfur relay system_Homo sapiens_hsa041220.51001450
80Fatty acid degradation_Homo sapiens_hsa000710.50790072
81beta-Alanine metabolism_Homo sapiens_hsa004100.49933600
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49802636
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.49690637
84Hematopoietic cell lineage_Homo sapiens_hsa046400.49236582
85Allograft rejection_Homo sapiens_hsa053300.47439589
86Chemical carcinogenesis_Homo sapiens_hsa052040.46765499
87Basal cell carcinoma_Homo sapiens_hsa052170.46703028
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45549168
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44861618
90Phototransduction_Homo sapiens_hsa047440.44551952
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43633516
92HTLV-I infection_Homo sapiens_hsa051660.43200962
93Serotonergic synapse_Homo sapiens_hsa047260.42564002
94Asthma_Homo sapiens_hsa053100.42439664
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41433002
96Fatty acid metabolism_Homo sapiens_hsa012120.41390602
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.40936332
98Metabolic pathways_Homo sapiens_hsa011000.40109258
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38720884
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37292867
101* Viral carcinogenesis_Homo sapiens_hsa052030.37154558
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36932310
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35715321
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.34636517
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.34076179
106Measles_Homo sapiens_hsa051620.32907699
107Mineral absorption_Homo sapiens_hsa049780.32726559
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32370291
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31916586
110Arginine and proline metabolism_Homo sapiens_hsa003300.31698422
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29381162
112Linoleic acid metabolism_Homo sapiens_hsa005910.29203863
113Folate biosynthesis_Homo sapiens_hsa007900.29072012
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27952654
115Hippo signaling pathway_Homo sapiens_hsa043900.27241005
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26655662
117Fat digestion and absorption_Homo sapiens_hsa049750.26366621
118Vitamin digestion and absorption_Homo sapiens_hsa049770.26201944
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.23800000
120Cardiac muscle contraction_Homo sapiens_hsa042600.23281657
121Graft-versus-host disease_Homo sapiens_hsa053320.22860497
122Alcoholism_Homo sapiens_hsa050340.21976706
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.21209480
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20769167
125Rheumatoid arthritis_Homo sapiens_hsa053230.19524821
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.17882078
127N-Glycan biosynthesis_Homo sapiens_hsa005100.16762149
128Glutathione metabolism_Homo sapiens_hsa004800.16751951
129Renin-angiotensin system_Homo sapiens_hsa046140.16413028
130Wnt signaling pathway_Homo sapiens_hsa043100.15585149
131Taste transduction_Homo sapiens_hsa047420.12946694
132TGF-beta signaling pathway_Homo sapiens_hsa043500.12511909
133Legionellosis_Homo sapiens_hsa051340.10103564
134Fatty acid elongation_Homo sapiens_hsa000620.09361266
135Influenza A_Homo sapiens_hsa051640.09302825
136Pathways in cancer_Homo sapiens_hsa052000.08982470
137Hedgehog signaling pathway_Homo sapiens_hsa043400.08957662
138Hepatitis B_Homo sapiens_hsa051610.08882097
139Circadian rhythm_Homo sapiens_hsa047100.08847302
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.06952437
141Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.06944881
142Melanoma_Homo sapiens_hsa052180.06872005

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