

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA double-strand break processing (GO:0000729) | 4.66642576 |
| 2 | proteasome assembly (GO:0043248) | 4.19934923 |
| 3 | cullin deneddylation (GO:0010388) | 4.14468809 |
| 4 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 4.07999558 |
| 5 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 4.07999558 |
| 6 | protein deneddylation (GO:0000338) | 3.95276837 |
| 7 | chromatin remodeling at centromere (GO:0031055) | 3.88426379 |
| 8 | CENP-A containing nucleosome assembly (GO:0034080) | 3.72304794 |
| 9 | DNA replication checkpoint (GO:0000076) | 3.67518139 |
| 10 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.67444532 |
| 11 | replication fork processing (GO:0031297) | 3.64180878 |
| 12 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.61774563 |
| 13 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.59133808 |
| 14 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.59133808 |
| 15 | isotype switching (GO:0045190) | 3.59133808 |
| 16 | synapsis (GO:0007129) | 3.57317202 |
| 17 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.55567565 |
| 18 | non-recombinational repair (GO:0000726) | 3.55567565 |
| 19 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.55064057 |
| 20 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.55064057 |
| 21 | ribosome assembly (GO:0042255) | 3.53755521 |
| 22 | purine nucleobase biosynthetic process (GO:0009113) | 3.53049250 |
| 23 | protein neddylation (GO:0045116) | 3.51156473 |
| 24 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.49688725 |
| 25 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.44469444 |
| 26 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.44194736 |
| 27 | DNA deamination (GO:0045006) | 3.43892479 |
| 28 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.42283309 |
| 29 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.40583752 |
| 30 | respiratory chain complex IV assembly (GO:0008535) | 3.38810411 |
| 31 | pseudouridine synthesis (GO:0001522) | 3.37176499 |
| 32 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.33398638 |
| 33 | histone exchange (GO:0043486) | 3.31319416 |
| 34 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.30924722 |
| 35 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.29362253 |
| 36 | nucleobase biosynthetic process (GO:0046112) | 3.27675467 |
| 37 | histone mRNA metabolic process (GO:0008334) | 3.26281878 |
| 38 | IMP biosynthetic process (GO:0006188) | 3.22047517 |
| 39 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.20845727 |
| 40 | ATP synthesis coupled proton transport (GO:0015986) | 3.20845727 |
| 41 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.20415075 |
| 42 | peptidyl-histidine modification (GO:0018202) | 3.19307207 |
| 43 | recombinational repair (GO:0000725) | 3.17752213 |
| 44 | establishment of integrated proviral latency (GO:0075713) | 3.17329705 |
| 45 | double-strand break repair via homologous recombination (GO:0000724) | 3.16201027 |
| 46 | DNA ligation (GO:0006266) | 3.15274489 |
| 47 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.14203876 |
| 48 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.13749553 |
| 49 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.13749553 |
| 50 | somatic diversification of immunoglobulins (GO:0016445) | 3.10810360 |
| 51 | rRNA modification (GO:0000154) | 3.10316642 |
| 52 | somatic recombination of immunoglobulin gene segments (GO:0016447) | 3.09318824 |
| 53 | centriole replication (GO:0007099) | 3.06982339 |
| 54 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.06379766 |
| 55 | negative regulation of ligase activity (GO:0051352) | 3.06379766 |
| 56 | metaphase plate congression (GO:0051310) | 3.05948588 |
| 57 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.05112830 |
| 58 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.04895905 |
| 59 | mitochondrial RNA metabolic process (GO:0000959) | 3.02648456 |
| 60 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.97020383 |
| 61 | maturation of 5.8S rRNA (GO:0000460) | 2.96591302 |
| 62 | lactate metabolic process (GO:0006089) | 2.96454175 |
| 63 | protein K6-linked ubiquitination (GO:0085020) | 2.96448336 |
| 64 | organelle disassembly (GO:1903008) | 2.95854912 |
| 65 | DNA damage response, detection of DNA damage (GO:0042769) | 2.93257895 |
| 66 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.92183173 |
| 67 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.91248209 |
| 68 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.91248209 |
| 69 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.90299015 |
| 70 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.90299015 |
| 71 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.90299015 |
| 72 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.88332300 |
| 73 | cytochrome complex assembly (GO:0017004) | 2.87491902 |
| 74 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.87269951 |
| 75 | mitotic metaphase plate congression (GO:0007080) | 2.87149027 |
| 76 | protein complex biogenesis (GO:0070271) | 2.87145085 |
| 77 | rRNA methylation (GO:0031167) | 2.84324445 |
| 78 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.83833879 |
| 79 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.83833879 |
| 80 | histone H2A acetylation (GO:0043968) | 2.83019172 |
| 81 | tRNA metabolic process (GO:0006399) | 2.81317865 |
| 82 | tRNA processing (GO:0008033) | 2.80688653 |
| 83 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.79910463 |
| 84 | DNA replication-independent nucleosome organization (GO:0034724) | 2.79910463 |
| 85 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.78056681 |
| 86 | NADH dehydrogenase complex assembly (GO:0010257) | 2.78056681 |
| 87 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.78056681 |
| 88 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.77911294 |
| 89 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.77911294 |
| 90 | regulation of centriole replication (GO:0046599) | 2.77357950 |
| 91 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.76822334 |
| 92 | termination of RNA polymerase III transcription (GO:0006386) | 2.76822334 |
| 93 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.76760275 |
| 94 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.76575252 |
| 95 | amino acid activation (GO:0043038) | 2.76490441 |
| 96 | tRNA aminoacylation (GO:0043039) | 2.76490441 |
| 97 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.75752295 |
| 98 | IMP metabolic process (GO:0046040) | 2.75341433 |
| 99 | ubiquinone metabolic process (GO:0006743) | 2.74166982 |
| 100 | inner mitochondrial membrane organization (GO:0007007) | 2.74093105 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.50510417 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.44917246 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.73199369 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.44186140 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.33505629 |
| 6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.25556259 |
| 7 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 3.06997467 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.81291647 |
| 9 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.74510572 |
| 10 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.63788227 |
| 11 | VDR_22108803_ChIP-Seq_LS180_Human | 2.54985083 |
| 12 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.52053280 |
| 13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.49946602 |
| 14 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.45839438 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.37561900 |
| 16 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.32300236 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.31046010 |
| 18 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.27127038 |
| 19 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.21633784 |
| 20 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.20105524 |
| 21 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.17342444 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.11840506 |
| 23 | * EWS_26573619_Chip-Seq_HEK293_Human | 2.11146103 |
| 24 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.02912087 |
| 25 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.02391926 |
| 26 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.00336432 |
| 27 | FUS_26573619_Chip-Seq_HEK293_Human | 1.96758334 |
| 28 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.90466086 |
| 29 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.88865584 |
| 30 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.85337803 |
| 31 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.80691091 |
| 32 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.76531208 |
| 33 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.71657822 |
| 34 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.70075277 |
| 35 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.60547155 |
| 36 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.58927225 |
| 37 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.53367783 |
| 38 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.53339205 |
| 39 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.52211972 |
| 40 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.52174455 |
| 41 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.47735980 |
| 42 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.46550449 |
| 43 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.45152858 |
| 44 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.44443109 |
| 45 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.44140459 |
| 46 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.43645529 |
| 47 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.41943128 |
| 48 | P300_19829295_ChIP-Seq_ESCs_Human | 1.39524641 |
| 49 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.36690400 |
| 50 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.36303538 |
| 51 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.34507786 |
| 52 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.27473860 |
| 53 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.26850896 |
| 54 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.23073637 |
| 55 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.21685454 |
| 56 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.20158206 |
| 57 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.19114041 |
| 58 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.18806729 |
| 59 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.16368991 |
| 60 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.14962320 |
| 61 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.14485183 |
| 62 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.14399516 |
| 63 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.13639243 |
| 64 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.13322533 |
| 65 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.10326608 |
| 66 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.10064148 |
| 67 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.10051094 |
| 68 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.09634738 |
| 69 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.09298612 |
| 70 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.09234505 |
| 71 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.08927313 |
| 72 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.08421275 |
| 73 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.07065110 |
| 74 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.05666941 |
| 75 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.05412211 |
| 76 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.04493160 |
| 77 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.03109215 |
| 78 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.01941570 |
| 79 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.01412370 |
| 80 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.01334696 |
| 81 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.00511093 |
| 82 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.99509719 |
| 83 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.97826777 |
| 84 | GBX2_23144817_ChIP-Seq_PC3_Human | 0.95399318 |
| 85 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.95158202 |
| 86 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.95158202 |
| 87 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.94598813 |
| 88 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.94524000 |
| 89 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.92546227 |
| 90 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 0.91314109 |
| 91 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.90795232 |
| 92 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.90795232 |
| 93 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.90617049 |
| 94 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.90314079 |
| 95 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.88477329 |
| 96 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.87181079 |
| 97 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.87181079 |
| 98 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.86946399 |
| 99 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.86575492 |
| 100 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.86414191 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 4.46767908 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.21030425 |
| 3 | MP0008877_abnormal_DNA_methylation | 3.40830370 |
| 4 | MP0003693_abnormal_embryo_hatching | 3.33986570 |
| 5 | MP0008057_abnormal_DNA_replication | 2.98483622 |
| 6 | MP0000372_irregular_coat_pigmentation | 2.69075726 |
| 7 | MP0004957_abnormal_blastocyst_morpholog | 2.65939888 |
| 8 | MP0006072_abnormal_retinal_apoptosis | 2.47793861 |
| 9 | MP0003111_abnormal_nucleus_morphology | 2.46309793 |
| 10 | MP0003718_maternal_effect | 2.46065816 |
| 11 | MP0008007_abnormal_cellular_replicative | 2.35935823 |
| 12 | MP0003786_premature_aging | 2.24376155 |
| 13 | MP0006292_abnormal_olfactory_placode | 2.19503151 |
| 14 | MP0003077_abnormal_cell_cycle | 2.19411268 |
| 15 | MP0009697_abnormal_copulation | 2.17748977 |
| 16 | MP0002102_abnormal_ear_morphology | 2.10919878 |
| 17 | MP0001188_hyperpigmentation | 1.94721646 |
| 18 | MP0002837_dystrophic_cardiac_calcinosis | 1.85047405 |
| 19 | MP0008932_abnormal_embryonic_tissue | 1.85014843 |
| 20 | MP0002163_abnormal_gland_morphology | 1.78720820 |
| 21 | MP0003195_calcinosis | 1.77949738 |
| 22 | MP0003890_abnormal_embryonic-extraembry | 1.67034591 |
| 23 | MP0002938_white_spotting | 1.61604342 |
| 24 | MP0005551_abnormal_eye_electrophysiolog | 1.61397834 |
| 25 | MP0005253_abnormal_eye_physiology | 1.61368885 |
| 26 | MP0006035_abnormal_mitochondrial_morpho | 1.60071640 |
| 27 | MP0002254_reproductive_system_inflammat | 1.59636036 |
| 28 | MP0003806_abnormal_nucleotide_metabolis | 1.56400122 |
| 29 | MP0004147_increased_porphyrin_level | 1.54341402 |
| 30 | MP0005084_abnormal_gallbladder_morpholo | 1.52220270 |
| 31 | MP0001293_anophthalmia | 1.49013698 |
| 32 | MP0005174_abnormal_tail_pigmentation | 1.45940235 |
| 33 | MP0001529_abnormal_vocalization | 1.43683382 |
| 34 | MP0005379_endocrine/exocrine_gland_phen | 1.42981686 |
| 35 | MP0005645_abnormal_hypothalamus_physiol | 1.41868727 |
| 36 | MP0002160_abnormal_reproductive_system | 1.38975868 |
| 37 | MP0002210_abnormal_sex_determination | 1.33478061 |
| 38 | MP0001929_abnormal_gametogenesis | 1.32478963 |
| 39 | MP0003011_delayed_dark_adaptation | 1.32078053 |
| 40 | MP0003186_abnormal_redox_activity | 1.31847702 |
| 41 | MP0008872_abnormal_physiological_respon | 1.28835797 |
| 42 | MP0006036_abnormal_mitochondrial_physio | 1.27695444 |
| 43 | MP0003121_genomic_imprinting | 1.25811199 |
| 44 | MP0003567_abnormal_fetal_cardiomyocyte | 1.24063814 |
| 45 | MP0002277_abnormal_respiratory_mucosa | 1.21949188 |
| 46 | MP0005389_reproductive_system_phenotype | 1.19628432 |
| 47 | MP0003136_yellow_coat_color | 1.17629559 |
| 48 | MP0003937_abnormal_limbs/digits/tail_de | 1.17322063 |
| 49 | MP0000653_abnormal_sex_gland | 1.14668490 |
| 50 | MP0001145_abnormal_male_reproductive | 1.14656607 |
| 51 | MP0001485_abnormal_pinna_reflex | 1.11852417 |
| 52 | MP0005075_abnormal_melanosome_morpholog | 1.10767780 |
| 53 | MP0002736_abnormal_nociception_after | 1.10166680 |
| 54 | MP0008789_abnormal_olfactory_epithelium | 1.09959560 |
| 55 | MP0008995_early_reproductive_senescence | 1.09238415 |
| 56 | MP0005367_renal/urinary_system_phenotyp | 1.08974903 |
| 57 | MP0000516_abnormal_urinary_system | 1.08974903 |
| 58 | MP0003941_abnormal_skin_development | 1.03271443 |
| 59 | MP0001764_abnormal_homeostasis | 1.01913994 |
| 60 | MP0010307_abnormal_tumor_latency | 1.00733982 |
| 61 | MP0003787_abnormal_imprinting | 1.00610830 |
| 62 | MP0004215_abnormal_myocardial_fiber | 0.98806884 |
| 63 | MP0001919_abnormal_reproductive_system | 0.98767882 |
| 64 | MP0002234_abnormal_pharynx_morphology | 0.95947723 |
| 65 | MP0001119_abnormal_female_reproductive | 0.95300460 |
| 66 | MP0001697_abnormal_embryo_size | 0.94937348 |
| 67 | MP0000631_abnormal_neuroendocrine_gland | 0.94878931 |
| 68 | MP0000569_abnormal_digit_pigmentation | 0.94081499 |
| 69 | MP0002876_abnormal_thyroid_physiology | 0.94036549 |
| 70 | MP0003283_abnormal_digestive_organ | 0.92852240 |
| 71 | MP0003119_abnormal_digestive_system | 0.91260179 |
| 72 | MP0005646_abnormal_pituitary_gland | 0.91175114 |
| 73 | MP0004133_heterotaxia | 0.90563510 |
| 74 | MP0002084_abnormal_developmental_patter | 0.89474532 |
| 75 | MP0001873_stomach_inflammation | 0.88110770 |
| 76 | MP0003698_abnormal_male_reproductive | 0.87346906 |
| 77 | MP0002751_abnormal_autonomic_nervous | 0.86639007 |
| 78 | MP0000427_abnormal_hair_cycle | 0.86019729 |
| 79 | MP0005395_other_phenotype | 0.84881498 |
| 80 | MP0001730_embryonic_growth_arrest | 0.82803362 |
| 81 | MP0000015_abnormal_ear_pigmentation | 0.82140850 |
| 82 | MP0008875_abnormal_xenobiotic_pharmacok | 0.80622961 |
| 83 | MP0000350_abnormal_cell_proliferation | 0.80094481 |
| 84 | MP0000358_abnormal_cell_content/ | 0.79654478 |
| 85 | MP0005332_abnormal_amino_acid | 0.79516105 |
| 86 | MP0005220_abnormal_exocrine_pancreas | 0.78983852 |
| 87 | MP0003950_abnormal_plasma_membrane | 0.78767446 |
| 88 | MP0002090_abnormal_vision | 0.77713639 |
| 89 | MP0005410_abnormal_fertilization | 0.76297942 |
| 90 | MP0005391_vision/eye_phenotype | 0.76029656 |
| 91 | MP0000313_abnormal_cell_death | 0.75744560 |
| 92 | MP0001672_abnormal_embryogenesis/_devel | 0.75414685 |
| 93 | MP0005380_embryogenesis_phenotype | 0.75414685 |
| 94 | MP0003943_abnormal_hepatobiliary_system | 0.74058384 |
| 95 | MP0001324_abnormal_eye_pigmentation | 0.72168312 |
| 96 | MP0002233_abnormal_nose_morphology | 0.71043715 |
| 97 | MP0002085_abnormal_embryonic_tissue | 0.70535611 |
| 98 | MP0005394_taste/olfaction_phenotype | 0.70278661 |
| 99 | MP0005499_abnormal_olfactory_system | 0.70278661 |
| 100 | MP0005647_abnormal_sex_gland | 0.68674333 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 3.48416640 |
| 2 | Acute encephalopathy (HP:0006846) | 3.44986615 |
| 3 | Colon cancer (HP:0003003) | 3.20475626 |
| 4 | Increased hepatocellular lipid droplets (HP:0006565) | 3.07286976 |
| 5 | Ependymoma (HP:0002888) | 3.01151585 |
| 6 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.01095843 |
| 7 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.00700421 |
| 8 | Lipid accumulation in hepatocytes (HP:0006561) | 2.99916421 |
| 9 | Abnormality of chromosome stability (HP:0003220) | 2.99083264 |
| 10 | Mitochondrial inheritance (HP:0001427) | 2.98646240 |
| 11 | Increased CSF lactate (HP:0002490) | 2.97695389 |
| 12 | Progressive macrocephaly (HP:0004481) | 2.96632455 |
| 13 | Meckel diverticulum (HP:0002245) | 2.96112466 |
| 14 | Pancreatic cysts (HP:0001737) | 2.95697846 |
| 15 | Chromsome breakage (HP:0040012) | 2.92290501 |
| 16 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.92025046 |
| 17 | Abnormality of the ileum (HP:0001549) | 2.84352588 |
| 18 | Abnormality of the labia minora (HP:0012880) | 2.74692562 |
| 19 | Abnormality of the preputium (HP:0100587) | 2.63700636 |
| 20 | Methylmalonic acidemia (HP:0002912) | 2.57669093 |
| 21 | Pancreatic fibrosis (HP:0100732) | 2.51936276 |
| 22 | Hyperglycinemia (HP:0002154) | 2.50653611 |
| 23 | Abnormality of midbrain morphology (HP:0002418) | 2.47838440 |
| 24 | Molar tooth sign on MRI (HP:0002419) | 2.47838440 |
| 25 | Glioma (HP:0009733) | 2.43041187 |
| 26 | Renal cortical cysts (HP:0000803) | 2.42786828 |
| 27 | Abnormality of the pons (HP:0007361) | 2.39446335 |
| 28 | 3-Methylglutaconic aciduria (HP:0003535) | 2.39418032 |
| 29 | Cerebral edema (HP:0002181) | 2.38757716 |
| 30 | Abnormality of the renal cortex (HP:0011035) | 2.37403694 |
| 31 | Birth length less than 3rd percentile (HP:0003561) | 2.34082160 |
| 32 | Type I transferrin isoform profile (HP:0003642) | 2.29496311 |
| 33 | Medial flaring of the eyebrow (HP:0010747) | 2.29270956 |
| 34 | Increased serum lactate (HP:0002151) | 2.28453887 |
| 35 | Type II lissencephaly (HP:0007260) | 2.26905026 |
| 36 | Renal Fanconi syndrome (HP:0001994) | 2.23150145 |
| 37 | Duodenal stenosis (HP:0100867) | 2.20007693 |
| 38 | Small intestinal stenosis (HP:0012848) | 2.20007693 |
| 39 | Hepatocellular necrosis (HP:0001404) | 2.18927620 |
| 40 | Dyschromatopsia (HP:0007641) | 2.17916539 |
| 41 | Rhabdomyosarcoma (HP:0002859) | 2.17721220 |
| 42 | Abnormality of the astrocytes (HP:0100707) | 2.17397993 |
| 43 | Astrocytoma (HP:0009592) | 2.17397993 |
| 44 | Hypoplasia of the pons (HP:0012110) | 2.16735711 |
| 45 | Abnormal protein glycosylation (HP:0012346) | 2.16032223 |
| 46 | Abnormal glycosylation (HP:0012345) | 2.16032223 |
| 47 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.16032223 |
| 48 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.16032223 |
| 49 | Abnormality of glycine metabolism (HP:0010895) | 2.15036964 |
| 50 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.15036964 |
| 51 | Sloping forehead (HP:0000340) | 2.14444489 |
| 52 | Hepatic necrosis (HP:0002605) | 2.14248104 |
| 53 | Hyperglycinuria (HP:0003108) | 2.14236638 |
| 54 | Abnormality of the duodenum (HP:0002246) | 2.14188837 |
| 55 | Abnormality of methionine metabolism (HP:0010901) | 2.13564741 |
| 56 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.13072028 |
| 57 | Nephronophthisis (HP:0000090) | 2.13005951 |
| 58 | True hermaphroditism (HP:0010459) | 2.12466363 |
| 59 | Abnormality of serum amino acid levels (HP:0003112) | 2.09500926 |
| 60 | Clubbing of toes (HP:0100760) | 2.09244607 |
| 61 | Congenital stationary night blindness (HP:0007642) | 2.06071057 |
| 62 | Lactic acidosis (HP:0003128) | 2.04257091 |
| 63 | Methylmalonic aciduria (HP:0012120) | 2.03691945 |
| 64 | Medulloblastoma (HP:0002885) | 2.03337266 |
| 65 | Optic disc pallor (HP:0000543) | 2.01964005 |
| 66 | Neoplasm of the adrenal gland (HP:0100631) | 1.91755159 |
| 67 | Abnormal lung lobation (HP:0002101) | 1.91557519 |
| 68 | Lethargy (HP:0001254) | 1.90284993 |
| 69 | Exertional dyspnea (HP:0002875) | 1.89251430 |
| 70 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.88957813 |
| 71 | Abnormality of the renal medulla (HP:0100957) | 1.86855082 |
| 72 | Intestinal atresia (HP:0011100) | 1.84979865 |
| 73 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.84581159 |
| 74 | Abnormality of alanine metabolism (HP:0010916) | 1.84581159 |
| 75 | Hyperalaninemia (HP:0003348) | 1.84581159 |
| 76 | Abolished electroretinogram (ERG) (HP:0000550) | 1.84044333 |
| 77 | Abnormality of the anterior horn cell (HP:0006802) | 1.83473586 |
| 78 | Degeneration of anterior horn cells (HP:0002398) | 1.83473586 |
| 79 | Volvulus (HP:0002580) | 1.80544941 |
| 80 | Myelodysplasia (HP:0002863) | 1.79924801 |
| 81 | Abnormal biliary tract physiology (HP:0012439) | 1.79547307 |
| 82 | Bile duct proliferation (HP:0001408) | 1.79547307 |
| 83 | Abnormality of vitamin B metabolism (HP:0004340) | 1.78771617 |
| 84 | Triphalangeal thumb (HP:0001199) | 1.77101520 |
| 85 | Tubulointerstitial nephritis (HP:0001970) | 1.75948763 |
| 86 | Agnosia (HP:0010524) | 1.75876606 |
| 87 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 1.72715406 |
| 88 | Respiratory difficulties (HP:0002880) | 1.71457417 |
| 89 | Horseshoe kidney (HP:0000085) | 1.71439252 |
| 90 | Tubular atrophy (HP:0000092) | 1.70303621 |
| 91 | Pendular nystagmus (HP:0012043) | 1.69606176 |
| 92 | Ectopic kidney (HP:0000086) | 1.69135445 |
| 93 | Absent thumb (HP:0009777) | 1.69065540 |
| 94 | Postnatal microcephaly (HP:0005484) | 1.68646767 |
| 95 | Bifid tongue (HP:0010297) | 1.68462390 |
| 96 | Reduced antithrombin III activity (HP:0001976) | 1.68281750 |
| 97 | Congenital primary aphakia (HP:0007707) | 1.67844692 |
| 98 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.67659105 |
| 99 | Pancytopenia (HP:0001876) | 1.67056754 |
| 100 | Breast carcinoma (HP:0003002) | 1.65560101 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 3.45141234 |
| 2 | NUAK1 | 2.94085381 |
| 3 | VRK2 | 2.92289175 |
| 4 | ZAK | 2.78263158 |
| 5 | TSSK6 | 2.77268343 |
| 6 | EIF2AK3 | 2.56526192 |
| 7 | BRSK2 | 2.53897984 |
| 8 | TRIM28 | 2.42961102 |
| 9 | MST4 | 2.39502675 |
| 10 | PLK4 | 2.33048217 |
| 11 | BMPR1B | 2.32216167 |
| 12 | SRPK1 | 2.32013947 |
| 13 | MKNK2 | 2.31485874 |
| 14 | WEE1 | 2.27157683 |
| 15 | PLK3 | 2.13452799 |
| 16 | CDC7 | 2.11285939 |
| 17 | VRK1 | 2.09798264 |
| 18 | NEK1 | 2.08551624 |
| 19 | WNK3 | 2.06305320 |
| 20 | TTK | 2.03385605 |
| 21 | MKNK1 | 2.00851115 |
| 22 | EIF2AK1 | 1.96208492 |
| 23 | FRK | 1.86737134 |
| 24 | GRK1 | 1.78395791 |
| 25 | TAF1 | 1.75744989 |
| 26 | STK16 | 1.74131144 |
| 27 | ADRBK2 | 1.73346692 |
| 28 | PNCK | 1.70073629 |
| 29 | MAP4K2 | 1.68098933 |
| 30 | ACVR1B | 1.60437109 |
| 31 | PBK | 1.58634088 |
| 32 | TNIK | 1.47738527 |
| 33 | STK39 | 1.28874629 |
| 34 | BCR | 1.28716212 |
| 35 | WNK4 | 1.25118697 |
| 36 | PLK1 | 1.12815241 |
| 37 | MAP3K12 | 1.11246800 |
| 38 | PASK | 1.05916267 |
| 39 | CCNB1 | 1.00538752 |
| 40 | BRSK1 | 0.99296152 |
| 41 | TXK | 0.98935124 |
| 42 | ATR | 0.96977922 |
| 43 | STK38L | 0.92623795 |
| 44 | ERBB3 | 0.92415127 |
| 45 | TLK1 | 0.91573397 |
| 46 | EIF2AK2 | 0.90958653 |
| 47 | OXSR1 | 0.88238197 |
| 48 | AKT3 | 0.88030013 |
| 49 | CSNK1G1 | 0.83752111 |
| 50 | MAPK13 | 0.82791257 |
| 51 | STK3 | 0.82754152 |
| 52 | TEC | 0.82585694 |
| 53 | PRKD3 | 0.79714197 |
| 54 | PLK2 | 0.79557092 |
| 55 | PAK3 | 0.74967533 |
| 56 | PINK1 | 0.73992319 |
| 57 | CSNK1G3 | 0.73354585 |
| 58 | CHEK2 | 0.72305367 |
| 59 | ATM | 0.71716644 |
| 60 | CASK | 0.67950568 |
| 61 | CSNK1A1L | 0.65529811 |
| 62 | CSNK1G2 | 0.64976722 |
| 63 | FLT3 | 0.64784986 |
| 64 | NME1 | 0.64776948 |
| 65 | MAPKAPK5 | 0.64492968 |
| 66 | TGFBR1 | 0.62816674 |
| 67 | PRKCE | 0.61788817 |
| 68 | AURKB | 0.58383545 |
| 69 | ALK | 0.55891155 |
| 70 | TIE1 | 0.53429206 |
| 71 | NEK2 | 0.52417319 |
| 72 | CHEK1 | 0.51662982 |
| 73 | NLK | 0.51452851 |
| 74 | PDK2 | 0.48505913 |
| 75 | CSNK2A1 | 0.45282806 |
| 76 | STK4 | 0.44431128 |
| 77 | CAMKK2 | 0.43964672 |
| 78 | DYRK2 | 0.43762382 |
| 79 | CSNK2A2 | 0.41804957 |
| 80 | INSRR | 0.39586482 |
| 81 | BCKDK | 0.39283067 |
| 82 | FGFR1 | 0.37058601 |
| 83 | PRKCQ | 0.36770099 |
| 84 | MAP3K4 | 0.36685844 |
| 85 | CSNK1A1 | 0.34750671 |
| 86 | TAOK3 | 0.34418860 |
| 87 | PRKCG | 0.34016243 |
| 88 | ERBB4 | 0.32258556 |
| 89 | CSNK1E | 0.31599501 |
| 90 | DYRK3 | 0.31268110 |
| 91 | PRKCI | 0.31263494 |
| 92 | RPS6KA5 | 0.30159847 |
| 93 | PRKDC | 0.29876515 |
| 94 | MELK | 0.26429134 |
| 95 | CDK1 | 0.26390254 |
| 96 | DAPK1 | 0.25654966 |
| 97 | SIK3 | 0.24697915 |
| 98 | PRKCH | 0.23337268 |
| 99 | CDK7 | 0.22761767 |
| 100 | CDK3 | 0.19716499 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.04497778 |
| 2 | Non-homologous end-joining_Homo sapiens_hsa03450 | 3.09289113 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.04079134 |
| 4 | Protein export_Homo sapiens_hsa03060 | 2.99746055 |
| 5 | Homologous recombination_Homo sapiens_hsa03440 | 2.97839198 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.75803190 |
| 7 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.56812811 |
| 8 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.54324332 |
| 9 | DNA replication_Homo sapiens_hsa03030 | 2.48269705 |
| 10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.46453055 |
| 11 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.37055178 |
| 12 | Basal transcription factors_Homo sapiens_hsa03022 | 2.35856373 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.26726673 |
| 14 | RNA polymerase_Homo sapiens_hsa03020 | 2.26486998 |
| 15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.07799855 |
| 16 | Parkinsons disease_Homo sapiens_hsa05012 | 2.05893039 |
| 17 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.01102749 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.99798917 |
| 19 | RNA transport_Homo sapiens_hsa03013 | 1.98417377 |
| 20 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.82466479 |
| 21 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.82257309 |
| 22 | Spliceosome_Homo sapiens_hsa03040 | 1.78713720 |
| 23 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.71468917 |
| 24 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.66573633 |
| 25 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.57390659 |
| 26 | Ribosome_Homo sapiens_hsa03010 | 1.56759192 |
| 27 | Base excision repair_Homo sapiens_hsa03410 | 1.49410617 |
| 28 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.46960350 |
| 29 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.46598114 |
| 30 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.44562652 |
| 31 | Huntingtons disease_Homo sapiens_hsa05016 | 1.37936890 |
| 32 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.34748549 |
| 33 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.24095548 |
| 34 | Cell cycle_Homo sapiens_hsa04110 | 1.23835095 |
| 35 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.22316832 |
| 36 | Phototransduction_Homo sapiens_hsa04744 | 1.21029164 |
| 37 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.18551452 |
| 38 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.16829658 |
| 39 | Alzheimers disease_Homo sapiens_hsa05010 | 1.16475873 |
| 40 | Purine metabolism_Homo sapiens_hsa00230 | 1.10479093 |
| 41 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.10259080 |
| 42 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.99516029 |
| 43 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.98864236 |
| 44 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.92643468 |
| 45 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.92242360 |
| 46 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.90911727 |
| 47 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.90503238 |
| 48 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.87600613 |
| 49 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.86620263 |
| 50 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.86575316 |
| 51 | Peroxisome_Homo sapiens_hsa04146 | 0.83810188 |
| 52 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.79702027 |
| 53 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.71400722 |
| 54 | Metabolic pathways_Homo sapiens_hsa01100 | 0.71089120 |
| 55 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.70014396 |
| 56 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.67498408 |
| 57 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.66013615 |
| 58 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.65466770 |
| 59 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.64650987 |
| 60 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.60754555 |
| 61 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.59366484 |
| 62 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.58660615 |
| 63 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.58562970 |
| 64 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.58526791 |
| 65 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.58278765 |
| 66 | Asthma_Homo sapiens_hsa05310 | 0.58077336 |
| 67 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.55905363 |
| 68 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.53038233 |
| 69 | Carbon metabolism_Homo sapiens_hsa01200 | 0.49481950 |
| 70 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.49328481 |
| 71 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.48768606 |
| 72 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.47623098 |
| 73 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.47420553 |
| 74 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.47006318 |
| 75 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.46503063 |
| 76 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.45145253 |
| 77 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.44562712 |
| 78 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.44296578 |
| 79 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.43370483 |
| 80 | Retinol metabolism_Homo sapiens_hsa00830 | 0.42148397 |
| 81 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.39254167 |
| 82 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.36980513 |
| 83 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.36288225 |
| 84 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.35537188 |
| 85 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.34778204 |
| 86 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.34339971 |
| 87 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.33471647 |
| 88 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.30726105 |
| 89 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.29709340 |
| 90 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.28179221 |
| 91 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.27828790 |
| 92 | Olfactory transduction_Homo sapiens_hsa04740 | 0.27818186 |
| 93 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.27678770 |
| 94 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.27180372 |
| 95 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.27174449 |
| 96 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.26081076 |
| 97 | Allograft rejection_Homo sapiens_hsa05330 | 0.26001643 |
| 98 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.23809657 |
| 99 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.22816067 |
| 100 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.22649820 |

