GTF2H3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.31874511
2nucleobase biosynthetic process (GO:0046112)4.29874084
3purine nucleobase biosynthetic process (GO:0009113)4.25955025
4DNA strand elongation involved in DNA replication (GO:0006271)4.22143185
5mitotic metaphase plate congression (GO:0007080)4.18814595
6maturation of SSU-rRNA (GO:0030490)4.11096650
7DNA strand elongation (GO:0022616)4.08787183
8DNA replication initiation (GO:0006270)4.08729614
9DNA replication checkpoint (GO:0000076)4.02082861
10telomere maintenance via semi-conservative replication (GO:0032201)4.00561225
11IMP biosynthetic process (GO:0006188)3.90372639
12mitotic sister chromatid segregation (GO:0000070)3.88568259
13DNA deamination (GO:0045006)3.87463288
14ribosome biogenesis (GO:0042254)3.86635238
15CENP-A containing nucleosome assembly (GO:0034080)3.82355007
16sister chromatid segregation (GO:0000819)3.82191369
17chromatin remodeling at centromere (GO:0031055)3.81783732
18ribosomal large subunit biogenesis (GO:0042273)3.79482816
19metaphase plate congression (GO:0051310)3.76114576
20protein localization to chromosome, centromeric region (GO:0071459)3.74392399
21formation of translation preinitiation complex (GO:0001731)3.72668933
22ribosome assembly (GO:0042255)3.71862823
23ribonucleoprotein complex biogenesis (GO:0022613)3.66694540
24telomere maintenance via recombination (GO:0000722)3.65942096
25regulation of centriole replication (GO:0046599)3.65508645
26proteasome assembly (GO:0043248)3.63530635
27kinetochore organization (GO:0051383)3.63189840
28establishment of integrated proviral latency (GO:0075713)3.62052601
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60517609
30regulation of translational fidelity (GO:0006450)3.56686670
31kinetochore assembly (GO:0051382)3.55950741
32spliceosomal snRNP assembly (GO:0000387)3.55744745
33regulation of translational termination (GO:0006449)3.54703919
34replication fork processing (GO:0031297)3.49476006
35telomere maintenance via telomere lengthening (GO:0010833)3.47714985
36nuclear pore organization (GO:0006999)3.47409181
37viral mRNA export from host cell nucleus (GO:0046784)3.46484312
38mitotic recombination (GO:0006312)3.45713372
39establishment of chromosome localization (GO:0051303)3.45580650
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.43770521
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.43770521
42DNA replication-dependent nucleosome assembly (GO:0006335)3.42692582
43DNA replication-dependent nucleosome organization (GO:0034723)3.42692582
44maturation of 5.8S rRNA (GO:0000460)3.42356126
45amino acid activation (GO:0043038)3.42284918
46tRNA aminoacylation (GO:0043039)3.42284918
47mitotic nuclear envelope disassembly (GO:0007077)3.42142233
48protein K6-linked ubiquitination (GO:0085020)3.41483867
49regulation of spindle organization (GO:0090224)3.41169220
50DNA unwinding involved in DNA replication (GO:0006268)3.40041034
51* transcription-coupled nucleotide-excision repair (GO:0006283)3.39158149
52pore complex assembly (GO:0046931)3.36826196
53tRNA aminoacylation for protein translation (GO:0006418)3.36660274
54termination of RNA polymerase III transcription (GO:0006386)3.35312349
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.35312349
56regulation of nuclear cell cycle DNA replication (GO:0033262)3.35128846
57DNA replication-independent nucleosome organization (GO:0034724)3.35098945
58DNA replication-independent nucleosome assembly (GO:0006336)3.35098945
59mitochondrial RNA metabolic process (GO:0000959)3.33821684
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33787260
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33009626
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.32311230
63rRNA processing (GO:0006364)3.30404219
64rRNA modification (GO:0000154)3.29861908
65regulation of centrosome cycle (GO:0046605)3.28495757
66protein localization to kinetochore (GO:0034501)3.26769324
67positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26474443
68DNA double-strand break processing (GO:0000729)3.26417179
69regulation of DNA endoreduplication (GO:0032875)3.24229301
70regulation of mitotic spindle organization (GO:0060236)3.22683264
71regulation of mitochondrial translation (GO:0070129)3.20624356
72* 7-methylguanosine mRNA capping (GO:0006370)3.20570318
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19426278
74ribosomal small subunit biogenesis (GO:0042274)3.19349075
75pteridine-containing compound biosynthetic process (GO:0042559)3.19282472
76nucleotide-excision repair, DNA gap filling (GO:0006297)3.19160463
77rRNA metabolic process (GO:0016072)3.18758073
78histone exchange (GO:0043486)3.16544774
79* RNA capping (GO:0036260)3.15147806
80* 7-methylguanosine RNA capping (GO:0009452)3.15147806
81IMP metabolic process (GO:0046040)3.14767612
82attachment of spindle microtubules to kinetochore (GO:0008608)3.13509572
83establishment of protein localization to mitochondrial membrane (GO:0090151)3.11877503
84* termination of RNA polymerase I transcription (GO:0006363)3.11370888
85nuclear pore complex assembly (GO:0051292)3.10966028
86spindle checkpoint (GO:0031577)3.10931504
87* transcription elongation from RNA polymerase I promoter (GO:0006362)3.10647268
88mismatch repair (GO:0006298)3.08900332
89regulation of double-strand break repair via homologous recombination (GO:0010569)3.08836790
90translational initiation (GO:0006413)3.08050893
91cullin deneddylation (GO:0010388)3.07758327
92double-strand break repair via nonhomologous end joining (GO:0006303)3.07158455
93non-recombinational repair (GO:0000726)3.07158455
94negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06858606
95negative regulation of sister chromatid segregation (GO:0033046)3.06858606
96negative regulation of mitotic sister chromatid separation (GO:2000816)3.06858606
97negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06858606
98membrane disassembly (GO:0030397)3.06509141
99nuclear envelope disassembly (GO:0051081)3.06509141
100SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.06301187
101* transcription from RNA polymerase I promoter (GO:0006360)3.04661311
102negative regulation of chromosome segregation (GO:0051985)3.04562643
103cotranslational protein targeting to membrane (GO:0006613)3.03178189
104negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.02169838
105negative regulation of ligase activity (GO:0051352)3.02169838
106tetrahydrofolate metabolic process (GO:0046653)3.01784518
107L-serine metabolic process (GO:0006563)2.99685978
108regulation of translational elongation (GO:0006448)2.99306462
109peptidyl-histidine modification (GO:0018202)2.99270260
110mitotic spindle checkpoint (GO:0071174)2.99022042
111mitotic spindle assembly checkpoint (GO:0007094)2.98993361
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98881231
113spindle assembly checkpoint (GO:0071173)2.97707785
114meiotic chromosome segregation (GO:0045132)2.97690477
115folic acid-containing compound biosynthetic process (GO:0009396)2.97325057
116protein deneddylation (GO:0000338)2.96851378
117cellular component biogenesis (GO:0044085)2.96516613
118DNA strand renaturation (GO:0000733)2.96018150
119protein targeting to ER (GO:0045047)2.95982742
120pseudouridine synthesis (GO:0001522)2.92751288
121mitotic chromosome condensation (GO:0007076)2.92058569
122signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91158973
123signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91158973
124signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91158973
125regulation of helicase activity (GO:0051095)2.90883480
126spliceosomal complex assembly (GO:0000245)2.90793177
127mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.90725580
128positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90044606
129telomere maintenance (GO:0000723)2.89186592
130DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89151410
131telomere organization (GO:0032200)2.89091732
132maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.88668254
133regulation of centrosome duplication (GO:0010824)2.88349241
134viral transcription (GO:0019083)2.87500998
135establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86929041
136translational termination (GO:0006415)2.86868874
137DNA ligation (GO:0006266)2.86776334
138G1/S transition of mitotic cell cycle (GO:0000082)2.85969336
139* translation (GO:0006412)2.82570881
140heterochromatin organization (GO:0070828)2.81575617
141DNA topological change (GO:0006265)2.80612133
142tRNA metabolic process (GO:0006399)2.78095130
143somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.77361178
144somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.77361178
145isotype switching (GO:0045190)2.77361178
146somatic recombination of immunoglobulin gene segments (GO:0016447)2.76757949
147protein localization to endoplasmic reticulum (GO:0070972)2.76059213
148DNA catabolic process, exonucleolytic (GO:0000738)2.74859072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.45191319
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.38786054
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.97408546
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63997310
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.42530482
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.37807496
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.32295628
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24416143
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11746041
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07369104
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.03637313
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96985043
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.96859760
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90409060
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.84931049
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84731048
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53976688
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51050964
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47606640
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42984627
21* VDR_23849224_ChIP-Seq_CD4+_Human2.37719918
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.36074633
23XRN2_22483619_ChIP-Seq_HELA_Human2.31380137
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29732589
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.21510691
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20372495
27FOXP3_21729870_ChIP-Seq_TREG_Human2.17978944
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.11408968
29DCP1A_22483619_ChIP-Seq_HELA_Human2.08888714
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01875626
31NANOG_18555785_ChIP-Seq_MESCs_Mouse2.00860506
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96893556
33ELK1_19687146_ChIP-ChIP_HELA_Human1.93380315
34GABP_19822575_ChIP-Seq_HepG2_Human1.93266402
35* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92470014
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.91819680
37TTF2_22483619_ChIP-Seq_HELA_Human1.87004799
38* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84854906
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84543248
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.81694673
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81623013
42* AR_21909140_ChIP-Seq_LNCAP_Human1.80838177
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78913508
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.77407350
45* TP63_19390658_ChIP-ChIP_HaCaT_Human1.66919089
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66699677
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.66320124
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63960604
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58174619
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.57565066
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57509277
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52937587
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48142676
54CIITA_25753668_ChIP-Seq_RAJI_Human1.47330730
55EWS_26573619_Chip-Seq_HEK293_Human1.46812354
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40408205
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37975631
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37213963
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34229453
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33014386
61KDM5A_27292631_Chip-Seq_BREAST_Human1.32898637
62SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.31817300
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.31033697
64FUS_26573619_Chip-Seq_HEK293_Human1.29945017
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27678766
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27662842
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25523317
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20983946
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20782803
70* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20305436
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.19358383
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18997935
73ZNF274_21170338_ChIP-Seq_K562_Hela1.18881345
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15155840
75KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15155840
76KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15155840
77* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14303744
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13608280
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12813578
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.12155933
81MYC_18940864_ChIP-ChIP_HL60_Human1.10809371
82NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05352675
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.00635390
84STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99200927
85IRF1_19129219_ChIP-ChIP_H3396_Human0.99123919
86TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99089821
87* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98726954
88ELF5_23300383_ChIP-Seq_T47D_Human0.97302984
89ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97057789
90NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.96894736
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95580438
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92698133
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91793892
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91067633
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89802085
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89465306
97TFEB_21752829_ChIP-Seq_HELA_Human0.89118965
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88968612
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88579421
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.88149169
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87770618
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.87678780
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87665606
104* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86053826
105POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83005682
106VDR_22108803_ChIP-Seq_LS180_Human0.80056090
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.79632629
108EGR1_19374776_ChIP-ChIP_THP-1_Human0.79304026
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79056833
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.78555741
111TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78498131
112* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78219549
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77604482
114IGF1R_20145208_ChIP-Seq_DFB_Human0.77383342
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.77162800
116SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76953484
117CHD1_26751641_Chip-Seq_LNCaP_Human0.76914489
118* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76487773
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74323382
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74104136

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.99927458
2MP0010094_abnormal_chromosome_stability4.53789768
3MP0003111_abnormal_nucleus_morphology4.47552861
4MP0004957_abnormal_blastocyst_morpholog4.19346079
5MP0008058_abnormal_DNA_repair4.06291092
6MP0003077_abnormal_cell_cycle3.85071537
7MP0008057_abnormal_DNA_replication3.48356692
8MP0008007_abnormal_cellular_replicative3.04228553
9MP0003123_paternal_imprinting2.84503905
10MP0008932_abnormal_embryonic_tissue2.81462353
11MP0008877_abnormal_DNA_methylation2.63294627
12MP0003786_premature_aging2.48719416
13MP0000566_synostosis2.32748536
14MP0006292_abnormal_olfactory_placode2.32195113
15MP0010030_abnormal_orbit_morphology2.29064497
16MP0003718_maternal_effect2.05381755
17MP0001730_embryonic_growth_arrest1.95734389
18MP0002877_abnormal_melanocyte_morpholog1.94991364
19MP0002234_abnormal_pharynx_morphology1.93749000
20MP0000350_abnormal_cell_proliferation1.88829894
21MP0002396_abnormal_hematopoietic_system1.73618425
22MP0006072_abnormal_retinal_apoptosis1.70519909
23MP0003806_abnormal_nucleotide_metabolis1.65986852
24MP0003941_abnormal_skin_development1.63613948
25MP0003121_genomic_imprinting1.62877965
26MP0005380_embryogenesis_phenotype1.60930158
27MP0001672_abnormal_embryogenesis/_devel1.60930158
28MP0004147_increased_porphyrin_level1.57671684
29MP0003315_abnormal_perineum_morphology1.55415374
30MP0001346_abnormal_lacrimal_gland1.52109178
31MP0001293_anophthalmia1.51978704
32MP0001697_abnormal_embryo_size1.50197906
33MP0002009_preneoplasia1.48751517
34MP0002163_abnormal_gland_morphology1.48669847
35MP0003950_abnormal_plasma_membrane1.46290513
36MP0002210_abnormal_sex_determination1.44207165
37MP0002085_abnormal_embryonic_tissue1.42258154
38MP0003984_embryonic_growth_retardation1.41877070
39MP0002088_abnormal_embryonic_growth/wei1.38048043
40MP0002160_abnormal_reproductive_system1.36335877
41MP0000647_abnormal_sebaceous_gland1.35589324
42MP0000427_abnormal_hair_cycle1.34659139
43MP0005408_hypopigmentation1.31191606
44MP0000313_abnormal_cell_death1.30882747
45MP0002080_prenatal_lethality1.29819984
46MP0010307_abnormal_tumor_latency1.29773927
47MP0005187_abnormal_penis_morphology1.27789076
48MP0006035_abnormal_mitochondrial_morpho1.26363630
49MP0000490_abnormal_crypts_of1.25416786
50MP0002132_abnormal_respiratory_system1.22965928
51MP0002084_abnormal_developmental_patter1.21777091
52MP0003890_abnormal_embryonic-extraembry1.21130933
53MP0000049_abnormal_middle_ear1.20680781
54MP0002697_abnormal_eye_size1.20355266
55MP0000569_abnormal_digit_pigmentation1.20022194
56MP0002938_white_spotting1.17028832
57MP0001119_abnormal_female_reproductive1.16613187
58MP0001145_abnormal_male_reproductive1.15570598
59MP0009333_abnormal_splenocyte_physiolog1.12562797
60MP0000537_abnormal_urethra_morphology1.12506611
61MP0002019_abnormal_tumor_incidence1.12186762
62MP0002086_abnormal_extraembryonic_tissu1.11641461
63MP0005389_reproductive_system_phenotype1.10745353
64MP0003937_abnormal_limbs/digits/tail_de1.09039029
65MP0003567_abnormal_fetal_cardiomyocyte1.08223884
66MP0002653_abnormal_ependyma_morphology1.08092182
67MP0004133_heterotaxia1.06609492
68MP0003186_abnormal_redox_activity1.03455507
69MP0009053_abnormal_anal_canal1.03120217
70MP0001929_abnormal_gametogenesis1.03067585
71MP0005379_endocrine/exocrine_gland_phen1.02010981
72MP0000653_abnormal_sex_gland1.01704840
73MP0004197_abnormal_fetal_growth/weight/1.01459505
74MP0004808_abnormal_hematopoietic_stem1.00746643
75MP0004233_abnormal_muscle_weight0.99125768
76MP0003763_abnormal_thymus_physiology0.97388602
77MP0005075_abnormal_melanosome_morpholog0.95879299
78MP0009697_abnormal_copulation0.95091188
79MP0008789_abnormal_olfactory_epithelium0.94458392
80MP0001286_abnormal_eye_development0.93620261
81MP0003119_abnormal_digestive_system0.92822998
82MP0002249_abnormal_larynx_morphology0.92593473
83MP0006036_abnormal_mitochondrial_physio0.91612737
84MP0002090_abnormal_vision0.90503058
85MP0001299_abnormal_eye_distance/0.90338940
86MP0010678_abnormal_skin_adnexa0.89574220
87MP0002233_abnormal_nose_morphology0.89573227
88MP0001661_extended_life_span0.89238715
89MP0010234_abnormal_vibrissa_follicle0.89202064
90MP0001919_abnormal_reproductive_system0.88625414
91MP0001529_abnormal_vocalization0.87381335
92MP0010352_gastrointestinal_tract_polyps0.87256825
93MP0000703_abnormal_thymus_morphology0.81916215
94MP0001727_abnormal_embryo_implantation0.81793442
95MP0000613_abnormal_salivary_gland0.81719271
96MP0000383_abnormal_hair_follicle0.81471294
97MP0008260_abnormal_autophagy0.81169002
98MP0002111_abnormal_tail_morphology0.81099791
99MP0005367_renal/urinary_system_phenotyp0.80605062
100MP0000516_abnormal_urinary_system0.80605062
101MP0008995_early_reproductive_senescence0.78978046
102MP0005391_vision/eye_phenotype0.78745357
103MP0002102_abnormal_ear_morphology0.76814868
104MP0002095_abnormal_skin_pigmentation0.75540798
105MP0009672_abnormal_birth_weight0.75054754
106MP0001188_hyperpigmentation0.74372762
107MP0002177_abnormal_outer_ear0.72895670
108MP0002638_abnormal_pupillary_reflex0.72451080
109MP0003943_abnormal_hepatobiliary_system0.72085155
110MP0003936_abnormal_reproductive_system0.70900589
111MP0001881_abnormal_mammary_gland0.70716928
112MP0003385_abnormal_body_wall0.69844484
113MP0000358_abnormal_cell_content/0.69701561
114MP0002751_abnormal_autonomic_nervous0.69696158
115MP0009703_decreased_birth_body0.69643826
116MP0002722_abnormal_immune_system0.67928706
117MP0003755_abnormal_palate_morphology0.67631503
118MP0000428_abnormal_craniofacial_morphol0.67372716
119MP0002398_abnormal_bone_marrow0.67077289
120MP0005384_cellular_phenotype0.66336570
121MP0001545_abnormal_hematopoietic_system0.66139897
122MP0005397_hematopoietic_system_phenotyp0.66139897
123MP0000432_abnormal_head_morphology0.65641485
124MP0000858_altered_metastatic_potential0.63302756
125MP0000678_abnormal_parathyroid_gland0.62981977
126MP0001186_pigmentation_phenotype0.62686499
127MP0003938_abnormal_ear_development0.61645460
128MP0003942_abnormal_urinary_system0.60407576
129MP0002092_abnormal_eye_morphology0.59980339
130MP0000689_abnormal_spleen_morphology0.59593140
131MP0002932_abnormal_joint_morphology0.59367816
132MP0003935_abnormal_craniofacial_develop0.59165176
133MP0001915_intracranial_hemorrhage0.58177882
134MP0002114_abnormal_axial_skeleton0.57860309
135MP0005395_other_phenotype0.56582810
136MP0009379_abnormal_foot_pigmentation0.54357928
137MP0003698_abnormal_male_reproductive0.54279930
138MP0002075_abnormal_coat/hair_pigmentati0.54110515

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.13996051
2Breast hypoplasia (HP:0003187)4.02750729
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.97866787
4Chromsome breakage (HP:0040012)3.89631105
5Reticulocytopenia (HP:0001896)3.77683458
6Patellar aplasia (HP:0006443)3.53312015
7Carpal bone hypoplasia (HP:0001498)3.42221402
8Aplasia/Hypoplasia of the patella (HP:0006498)3.35302247
9Colon cancer (HP:0003003)3.20471526
10Meckel diverticulum (HP:0002245)3.19731004
11Abnormality of the preputium (HP:0100587)3.17487522
12Medulloblastoma (HP:0002885)3.11271593
13Abnormality of alanine metabolism (HP:0010916)3.08711917
14Hyperalaninemia (HP:0003348)3.08711917
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.08711917
16Abnormality of the ileum (HP:0001549)3.01352351
17Degeneration of anterior horn cells (HP:0002398)2.96956321
18Abnormality of the anterior horn cell (HP:0006802)2.96956321
19Abnormality of chromosome stability (HP:0003220)2.89798094
20Absent radius (HP:0003974)2.85432035
21Rough bone trabeculation (HP:0100670)2.85331597
22Selective tooth agenesis (HP:0001592)2.83635299
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.82561711
24Absent thumb (HP:0009777)2.80676689
25Increased hepatocellular lipid droplets (HP:0006565)2.73526935
26Oral leukoplakia (HP:0002745)2.71716435
27Absent forearm bone (HP:0003953)2.69997165
28Aplasia involving forearm bones (HP:0009822)2.69997165
29Duplicated collecting system (HP:0000081)2.66501751
30Lipid accumulation in hepatocytes (HP:0006561)2.61242250
31Acute encephalopathy (HP:0006846)2.57657844
32Abnormality of cells of the erythroid lineage (HP:0012130)2.53374877
33Irregular epiphyses (HP:0010582)2.53118311
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.52714084
35Ectopic kidney (HP:0000086)2.51898666
36Abnormality of the renal collecting system (HP:0004742)2.51838681
37Increased CSF lactate (HP:0002490)2.50589105
38Abnormality of the pons (HP:0007361)2.49435458
39Acute necrotizing encephalopathy (HP:0006965)2.48440181
40Cerebral hypomyelination (HP:0006808)2.48402915
41Impulsivity (HP:0100710)2.47469332
42Triphalangeal thumb (HP:0001199)2.45434728
43Hypoplasia of the pons (HP:0012110)2.44615816
44Small intestinal stenosis (HP:0012848)2.43807185
45Duodenal stenosis (HP:0100867)2.43807185
46Abnormality of the labia minora (HP:0012880)2.43208185
47Abnormal number of erythroid precursors (HP:0012131)2.41303561
48Abnormal lung lobation (HP:0002101)2.40972493
49Abnormality of methionine metabolism (HP:0010901)2.40482881
50Increased serum lactate (HP:0002151)2.39934175
51Supernumerary spleens (HP:0009799)2.38786454
52Microretrognathia (HP:0000308)2.36505514
53Horseshoe kidney (HP:0000085)2.35733614
54Sloping forehead (HP:0000340)2.35550916
5511 pairs of ribs (HP:0000878)2.31925978
56Optic nerve coloboma (HP:0000588)2.31362835
57Myelodysplasia (HP:0002863)2.30408691
58Premature graying of hair (HP:0002216)2.30359899
59Aplastic anemia (HP:0001915)2.25896366
60Bone marrow hypocellularity (HP:0005528)2.25830149
61Type I transferrin isoform profile (HP:0003642)2.24854663
62True hermaphroditism (HP:0010459)2.24466239
63Cortical dysplasia (HP:0002539)2.21238970
64Rhabdomyosarcoma (HP:0002859)2.19619281
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19612936
66Pancreatic cysts (HP:0001737)2.19446495
67Agnosia (HP:0010524)2.18789933
68Abnormal trabecular bone morphology (HP:0100671)2.17410658
69Neoplasm of the pancreas (HP:0002894)2.17370813
70Neuroendocrine neoplasm (HP:0100634)2.16810692
71Nephroblastoma (Wilms tumor) (HP:0002667)2.16804055
72Abnormal mitochondria in muscle tissue (HP:0008316)2.15571941
73Abnormality of the duodenum (HP:0002246)2.13854089
74Pancreatic fibrosis (HP:0100732)2.11447317
75Ependymoma (HP:0002888)2.11167521
76Progressive macrocephaly (HP:0004481)2.06320711
77Mitochondrial inheritance (HP:0001427)2.04608833
78Macrocytic anemia (HP:0001972)2.04080648
79Hypoplasia of the radius (HP:0002984)2.03472673
80Abnormality of midbrain morphology (HP:0002418)2.03093428
81Molar tooth sign on MRI (HP:0002419)2.03093428
82Embryonal renal neoplasm (HP:0011794)2.02413800
83Short thumb (HP:0009778)2.00312428
84Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99386310
85Abnormal number of incisors (HP:0011064)1.97670963
86Fibular aplasia (HP:0002990)1.96212013
87Duplication of thumb phalanx (HP:0009942)1.95924458
88Pallor (HP:0000980)1.94763261
89Stenosis of the external auditory canal (HP:0000402)1.94185522
90Atresia of the external auditory canal (HP:0000413)1.92931984
91Concave nail (HP:0001598)1.92912488
92Cellular immunodeficiency (HP:0005374)1.92598539
93Abnormality of DNA repair (HP:0003254)1.91912904
94Abnormal protein glycosylation (HP:0012346)1.91594370
95Abnormal glycosylation (HP:0012345)1.91594370
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91594370
97Abnormal protein N-linked glycosylation (HP:0012347)1.91594370
98Increased nuchal translucency (HP:0010880)1.91586803
99Pheochromocytoma (HP:0002666)1.90493353
100Type 2 muscle fiber atrophy (HP:0003554)1.89916752
101Hepatocellular necrosis (HP:0001404)1.89442454
102Facial cleft (HP:0002006)1.88107841
103Neoplasm of the peripheral nervous system (HP:0100007)1.87415708
104Lactic acidosis (HP:0003128)1.87248427
105Hepatic necrosis (HP:0002605)1.87085102
106Nephronophthisis (HP:0000090)1.86437984
107Neoplasm of the colon (HP:0100273)1.86050080
108Trismus (HP:0000211)1.85456780
109Cleft eyelid (HP:0000625)1.85362402
110Cerebral edema (HP:0002181)1.84877459
111Clubbing of toes (HP:0100760)1.84825630
112Tracheoesophageal fistula (HP:0002575)1.84703504
113Aplasia/Hypoplasia involving the musculature (HP:0001460)1.83500353
114Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82247467
115Absent epiphyses (HP:0010577)1.82247467
116Secondary amenorrhea (HP:0000869)1.82131520
117Neoplasm of the adrenal gland (HP:0100631)1.82000517
118Unilateral renal agenesis (HP:0000122)1.81729510
119Microvesicular hepatic steatosis (HP:0001414)1.79793335
120Muscle fiber atrophy (HP:0100295)1.79391630
121Abnormality of the carotid arteries (HP:0005344)1.79197972
122Aplasia/Hypoplasia of the sternum (HP:0006714)1.78762611
123Volvulus (HP:0002580)1.78000122
124Glioma (HP:0009733)1.77400377
125Ureteral duplication (HP:0000073)1.77108990
126Pancytopenia (HP:0001876)1.75968440
127Premature ovarian failure (HP:0008209)1.75621509
128Abnormality of glycolysis (HP:0004366)1.74397147
129Increased serum pyruvate (HP:0003542)1.74397147
130Amniotic constriction ring (HP:0009775)1.73734129
131Abnormality of placental membranes (HP:0011409)1.73734129
132Reduced antithrombin III activity (HP:0001976)1.73540181
133Preaxial hand polydactyly (HP:0001177)1.72988758
134Intestinal atresia (HP:0011100)1.72906577
135Abnormality of serum amino acid levels (HP:0003112)1.72900606
136Progressive muscle weakness (HP:0003323)1.72115986
137Lymphoma (HP:0002665)1.71301577
138Anal stenosis (HP:0002025)1.71298513
139Renal cortical cysts (HP:0000803)1.70825577
140Rectal fistula (HP:0100590)1.70450375
141Rectovaginal fistula (HP:0000143)1.70450375
142Tongue fasciculations (HP:0001308)1.70305865
143Multiple enchondromatosis (HP:0005701)1.68074284
144Neoplasm of the adrenal cortex (HP:0100641)1.66854335
145Cafe-au-lait spot (HP:0000957)1.65028759
146Squamous cell carcinoma (HP:0002860)1.62102789
147Neoplasm of the small intestine (HP:0100833)1.61986536
1483-Methylglutaconic aciduria (HP:0003535)1.61813547
149Arteriovenous malformation (HP:0100026)1.61293726
150Missing ribs (HP:0000921)1.60675835
151Biliary tract neoplasm (HP:0100574)1.60319876
152Meningioma (HP:0002858)1.59237689
153Abnormality of aspartate family amino acid metabolism (HP:0010899)1.58403225
154Brittle hair (HP:0002299)1.56939294
155Neoplasm of the rectum (HP:0100743)1.56882706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.37346396
2WEE13.47019029
3SRPK13.23420863
4VRK23.07737361
5EIF2AK12.87329801
6ZAK2.86188699
7CDC72.82355412
8STK162.78819524
9PLK42.53258393
10TAF12.48909298
11TSSK62.37428980
12MKNK12.34481153
13TTK2.32043548
14BRSK22.17467651
15EIF2AK32.15247408
16NEK22.03106763
17ACVR1B2.00960753
18PLK11.96291466
19PLK31.96100878
20PASK1.92136856
21VRK11.92120811
22MKNK21.90876782
23STK38L1.88659459
24TLK11.79289091
25NEK11.69448903
26ATR1.67841783
27NME21.61350368
28CDK71.55847340
29TRIM281.53179731
30AURKB1.51648729
31WNK41.50692874
32CCNB11.50384212
33AKT31.44360703
34CDK81.42800724
35RPS6KB21.39197826
36EPHA21.36656168
37BRD41.34824782
38CHEK21.34441650
39RPS6KA41.30587399
40BRSK11.22775446
41TESK21.17085999
42STK391.15707460
43DYRK31.15648727
44EIF2AK21.10070806
45SCYL21.07817593
46TGFBR11.07570669
47MST1R1.07538775
48PNCK1.07105686
49CHEK11.05858334
50EEF2K1.05633577
51AURKA1.05332143
52STK40.96750049
53PBK0.95606327
54CSNK1G30.94013539
55PIM10.92231284
56NUAK10.92145602
57YES10.89481880
58TXK0.87884455
59IRAK30.87148754
60CSNK1G10.87040498
61CDK120.85753346
62NEK60.84690317
63CSNK1A1L0.82706451
64ATM0.79406548
65ERBB40.77794810
66CDK20.76148753
67MAPKAPK50.74368153
68MET0.73787759
69STK100.73707538
70CSNK2A10.72235338
71CASK0.71635621
72CDK40.71259403
73DYRK20.71030828
74PIM20.68086378
75CSNK2A20.65641972
76ALK0.65628455
77CSNK1G20.64642123
78RPS6KA50.64213570
79GRK10.63699969
80LATS10.62786136
81BRAF0.62257427
82PRKCI0.61952440
83MAP3K80.61856557
84CDK10.61714927
85BCKDK0.61698118
86WNK30.59948446
87SMG10.59604233
88FLT30.58027310
89MST40.55252355
90CLK10.55155599
91STK30.54821941
92TIE10.53775359
93MELK0.53101352
94FRK0.52944518
95MAP3K120.52790845
96NEK90.52085248
97INSRR0.51644850
98BMPR1B0.51000085
99PAK40.50623209
100CSNK1E0.50010005
101MUSK0.49645144
102MAP3K90.49259847
103TAOK20.46649376
104IRAK20.45854554
105BCR0.45766670
106SIK30.45394254
107MARK30.45291673
108TESK10.44763502
109KDR0.43561330
110PDK20.42657385
111CDK30.41840246
112ERBB30.41656461
113LIMK10.40501197
114IRAK40.40454001
115MAPKAPK30.40162574
116MAP3K30.39349364
117CHUK0.38715294
118PAK10.37323073
119NME10.37019651
120PHKG10.34810414
121PHKG20.34810414
122PRPF4B0.34619783
123STK240.34204006
124PLK20.33473305
125MAP3K100.32141269
126MAP3K40.31695799
127IKBKB0.30486331
128BMPR20.27493729
129FGFR10.27387191
130PRKDC0.26518846
131RPS6KB10.26467596
132CDK90.24692759
133ADRBK20.24170626
134MAPK140.24049791
135MAP4K10.21716733
136NLK0.21419493
137AKT20.20953540

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.31687645
2Mismatch repair_Homo sapiens_hsa034304.04184231
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.82157723
4RNA polymerase_Homo sapiens_hsa030203.78756485
5Proteasome_Homo sapiens_hsa030503.59400702
6Ribosome_Homo sapiens_hsa030103.24922505
7Spliceosome_Homo sapiens_hsa030403.21457675
8Homologous recombination_Homo sapiens_hsa034403.17377582
9Base excision repair_Homo sapiens_hsa034103.08639469
10RNA transport_Homo sapiens_hsa030132.94606355
11* Nucleotide excision repair_Homo sapiens_hsa034202.74226547
12One carbon pool by folate_Homo sapiens_hsa006702.61718443
13Pyrimidine metabolism_Homo sapiens_hsa002402.55433396
14Cell cycle_Homo sapiens_hsa041102.53927033
15Fanconi anemia pathway_Homo sapiens_hsa034602.50384923
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.34210766
17* Basal transcription factors_Homo sapiens_hsa030222.33515223
18Non-homologous end-joining_Homo sapiens_hsa034502.12053000
19RNA degradation_Homo sapiens_hsa030182.05212144
20mRNA surveillance pathway_Homo sapiens_hsa030151.66602799
21p53 signaling pathway_Homo sapiens_hsa041151.56900066
22Sulfur metabolism_Homo sapiens_hsa009201.54072319
23Purine metabolism_Homo sapiens_hsa002301.52165216
24Vitamin B6 metabolism_Homo sapiens_hsa007501.49608097
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36445750
26Pyruvate metabolism_Homo sapiens_hsa006201.32504326
27Protein export_Homo sapiens_hsa030601.27432543
28Propanoate metabolism_Homo sapiens_hsa006401.19158045
29Fatty acid elongation_Homo sapiens_hsa000621.14482581
30Epstein-Barr virus infection_Homo sapiens_hsa051691.13546265
31Steroid biosynthesis_Homo sapiens_hsa001001.10907857
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08771752
33Systemic lupus erythematosus_Homo sapiens_hsa053220.97468329
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96517269
35Folate biosynthesis_Homo sapiens_hsa007900.95863379
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93613555
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92802841
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89699062
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89400826
40Alzheimers disease_Homo sapiens_hsa050100.89331117
41Herpes simplex infection_Homo sapiens_hsa051680.88992553
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85627495
43Selenocompound metabolism_Homo sapiens_hsa004500.84764875
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.84026786
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81564365
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80733814
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.80162448
48Huntingtons disease_Homo sapiens_hsa050160.72816078
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.70423840
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69458629
51* Viral carcinogenesis_Homo sapiens_hsa052030.65427992
52Antigen processing and presentation_Homo sapiens_hsa046120.64861213
53Biosynthesis of amino acids_Homo sapiens_hsa012300.64775221
54Oocyte meiosis_Homo sapiens_hsa041140.64351478
55Primary immunodeficiency_Homo sapiens_hsa053400.63249634
56Basal cell carcinoma_Homo sapiens_hsa052170.62478889
57HTLV-I infection_Homo sapiens_hsa051660.62402719
58Pentose phosphate pathway_Homo sapiens_hsa000300.56671554
59Glutathione metabolism_Homo sapiens_hsa004800.54301599
60Arachidonic acid metabolism_Homo sapiens_hsa005900.53903345
61Butanoate metabolism_Homo sapiens_hsa006500.52397489
62Lysine degradation_Homo sapiens_hsa003100.51267386
63Legionellosis_Homo sapiens_hsa051340.49472688
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48378113
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47936830
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47778735
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47054952
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46665168
69Hippo signaling pathway_Homo sapiens_hsa043900.46461625
70Parkinsons disease_Homo sapiens_hsa050120.45642648
71Regulation of autophagy_Homo sapiens_hsa041400.45396210
72Fatty acid metabolism_Homo sapiens_hsa012120.45213693
73TGF-beta signaling pathway_Homo sapiens_hsa043500.44450405
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43705618
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41631301
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41448263
77MicroRNAs in cancer_Homo sapiens_hsa052060.40424005
78Peroxisome_Homo sapiens_hsa041460.40135034
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40078848
80Fructose and mannose metabolism_Homo sapiens_hsa000510.39792578
81Metabolic pathways_Homo sapiens_hsa011000.38732015
82Hedgehog signaling pathway_Homo sapiens_hsa043400.36962812
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35929955
84Measles_Homo sapiens_hsa051620.35830354
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.35129369
86Thyroid cancer_Homo sapiens_hsa052160.34351334
87Allograft rejection_Homo sapiens_hsa053300.34053126
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.33948195
89Carbon metabolism_Homo sapiens_hsa012000.32569871
90N-Glycan biosynthesis_Homo sapiens_hsa005100.31371195
91Tryptophan metabolism_Homo sapiens_hsa003800.31065244
92Notch signaling pathway_Homo sapiens_hsa043300.30681658
93Sulfur relay system_Homo sapiens_hsa041220.29685412
94Oxidative phosphorylation_Homo sapiens_hsa001900.29331304
95Apoptosis_Homo sapiens_hsa042100.28686415
96Cardiac muscle contraction_Homo sapiens_hsa042600.25784687
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25022078
98Small cell lung cancer_Homo sapiens_hsa052220.24046604
99Autoimmune thyroid disease_Homo sapiens_hsa053200.23883498
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23544567
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23360357
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22899964
103Alcoholism_Homo sapiens_hsa050340.22376925
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22343402
105Sphingolipid metabolism_Homo sapiens_hsa006000.21939510
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.21780570
107Nitrogen metabolism_Homo sapiens_hsa009100.21289305
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20860995
109Graft-versus-host disease_Homo sapiens_hsa053320.20473102
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20210335
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.20144316
112Fatty acid biosynthesis_Homo sapiens_hsa000610.19747049
113Caffeine metabolism_Homo sapiens_hsa002320.19460944
114Linoleic acid metabolism_Homo sapiens_hsa005910.19091033
115Galactose metabolism_Homo sapiens_hsa000520.18922323
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.17903303
117Influenza A_Homo sapiens_hsa051640.17647195
118Melanoma_Homo sapiens_hsa052180.17590588
119Hematopoietic cell lineage_Homo sapiens_hsa046400.16956779
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15267298
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13847835
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.13355585
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13340785
124Colorectal cancer_Homo sapiens_hsa052100.13221560
125Arginine and proline metabolism_Homo sapiens_hsa003300.13032159
126Pathways in cancer_Homo sapiens_hsa052000.12304216
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10106017
128Type I diabetes mellitus_Homo sapiens_hsa049400.09476839
1292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.09404894
130Vitamin digestion and absorption_Homo sapiens_hsa049770.09177646

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