GTF2H4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.26968404
2COPI coating of Golgi vesicle (GO:0048205)5.26968404
3purine nucleobase biosynthetic process (GO:0009113)5.00049481
4nucleobase biosynthetic process (GO:0046112)4.95085472
5DNA deamination (GO:0045006)4.82818926
6proline biosynthetic process (GO:0006561)4.79976282
7DNA strand elongation involved in DNA replication (GO:0006271)4.76317508
8formation of translation preinitiation complex (GO:0001731)4.59817418
9regulation of translational fidelity (GO:0006450)4.55830567
10telomere maintenance via semi-conservative replication (GO:0032201)4.54303456
11ribosomal small subunit assembly (GO:0000028)4.53016381
12DNA strand elongation (GO:0022616)4.52469264
13DNA replication initiation (GO:0006270)4.41505906
14protein retention in ER lumen (GO:0006621)4.37847733
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.32279650
16maturation of SSU-rRNA (GO:0030490)4.28458715
17DNA unwinding involved in DNA replication (GO:0006268)4.22048027
18IMP biosynthetic process (GO:0006188)4.07494054
19mitotic chromosome condensation (GO:0007076)4.02965551
20ribosome biogenesis (GO:0042254)4.01038913
21regulation of mammary gland epithelial cell proliferation (GO:0033599)4.00962020
22DNA replication checkpoint (GO:0000076)3.95253044
23folic acid-containing compound biosynthetic process (GO:0009396)3.95137723
24telomere maintenance via recombination (GO:0000722)3.93463176
25nuclear pore complex assembly (GO:0051292)3.85726493
26proteasome assembly (GO:0043248)3.85681518
27mitotic metaphase plate congression (GO:0007080)3.83937136
28mitotic nuclear envelope disassembly (GO:0007077)3.74914095
29peptidyl-arginine omega-N-methylation (GO:0035247)3.74239133
30folic acid metabolic process (GO:0046655)3.72163040
31heterochromatin organization (GO:0070828)3.70850016
32protein localization to kinetochore (GO:0034501)3.69051754
33ribonucleoprotein complex biogenesis (GO:0022613)3.66840261
34ribosomal large subunit biogenesis (GO:0042273)3.66726583
35mitotic recombination (GO:0006312)3.64248351
36retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.62347449
37ribosome assembly (GO:0042255)3.61609451
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.58350082
39telomere maintenance via telomere lengthening (GO:0010833)3.57910878
40pentose-phosphate shunt (GO:0006098)3.54319461
41IMP metabolic process (GO:0046040)3.52340841
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50229665
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49228640
44spliceosomal tri-snRNP complex assembly (GO:0000244)3.47659122
45regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.45675025
46membrane disassembly (GO:0030397)3.45572445
47nuclear envelope disassembly (GO:0051081)3.45572445
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45339409
49negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.44744592
50CENP-A containing nucleosome assembly (GO:0034080)3.44248133
51viral transcription (GO:0019083)3.43054794
52proline metabolic process (GO:0006560)3.42915656
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.42424822
54protein localization to endosome (GO:0036010)3.40868288
55rRNA processing (GO:0006364)3.39923845
56translational termination (GO:0006415)3.39535207
57chromatin remodeling at centromere (GO:0031055)3.36829393
58apoptotic process involved in morphogenesis (GO:0060561)3.36598402
59metaphase plate congression (GO:0051310)3.34917425
60negative regulation of erythrocyte differentiation (GO:0045647)3.33943092
61translational elongation (GO:0006414)3.32288131
62translational initiation (GO:0006413)3.31223674
63spliceosomal snRNP assembly (GO:0000387)3.28875483
64rRNA metabolic process (GO:0016072)3.27688840
65protein maturation by protein folding (GO:0022417)3.27492520
66cell-substrate adherens junction assembly (GO:0007045)3.27282395
67focal adhesion assembly (GO:0048041)3.27282395
68rRNA modification (GO:0000154)3.25712010
69adherens junction assembly (GO:0034333)3.25614868
70DNA replication-dependent nucleosome organization (GO:0034723)3.25087105
71DNA replication-dependent nucleosome assembly (GO:0006335)3.25087105
72regulation of early endosome to late endosome transport (GO:2000641)3.24062814
73maternal placenta development (GO:0001893)3.22222386
74protein localization to chromosome, centromeric region (GO:0071459)3.20970355
75nucleosome disassembly (GO:0006337)3.20372122
76protein-DNA complex disassembly (GO:0032986)3.20372122
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.19695072
78negative regulation of cell size (GO:0045792)3.18806604
79* transcription-coupled nucleotide-excision repair (GO:0006283)3.18404037
80negative regulation of ligase activity (GO:0051352)3.18136179
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.18136179
82regulation of RNA export from nucleus (GO:0046831)3.18082712
83planar cell polarity pathway involved in neural tube closure (GO:0090179)3.18003720
84regulation of nuclear cell cycle DNA replication (GO:0033262)3.17607771
85DNA replication-independent nucleosome assembly (GO:0006336)3.17499234
86DNA replication-independent nucleosome organization (GO:0034724)3.17499234
87pseudouridine synthesis (GO:0001522)3.16131264
88somatic hypermutation of immunoglobulin genes (GO:0016446)3.14376825
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14376825
90regulation of nucleobase-containing compound transport (GO:0032239)3.13834889
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.13425313
923-UTR-mediated mRNA stabilization (GO:0070935)3.11278612
93regulation of spindle organization (GO:0090224)3.10975526
94ribosomal small subunit biogenesis (GO:0042274)3.09369465
95activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.07978922
96NADPH regeneration (GO:0006740)3.07944202
97glucose catabolic process (GO:0006007)3.07006450
98kinetochore organization (GO:0051383)3.05528089
99peptidyl-arginine N-methylation (GO:0035246)3.05478212
100peptidyl-arginine methylation (GO:0018216)3.05478212
101positive regulation of nuclease activity (GO:0032075)3.04568324
102G1/S transition of mitotic cell cycle (GO:0000082)3.04304385
103cell cycle G1/S phase transition (GO:0044843)3.04304385
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.02598599
105regulation of NFAT protein import into nucleus (GO:0051532)3.02261041
106positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.00918922
107histone arginine methylation (GO:0034969)3.00698246
108cellular protein complex localization (GO:0034629)2.99460777
109mRNA stabilization (GO:0048255)2.99286588
110RNA stabilization (GO:0043489)2.99286588
111signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98696039
112signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98696039
113signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98696039
114intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.98490499
115signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.98490499
116signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96753727
117signal transduction involved in DNA damage checkpoint (GO:0072422)2.96753727
118establishment of chromosome localization (GO:0051303)2.96448394
119activation of Rac GTPase activity (GO:0032863)2.96371520
120regulation of histone H3-K27 methylation (GO:0061085)2.96177435
121attachment of spindle microtubules to kinetochore (GO:0008608)2.93239175
122signal transduction involved in cell cycle checkpoint (GO:0072395)2.92049059
123nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.91814042
124regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.91272515
125histone H2A acetylation (GO:0043968)2.90848333
126mitotic sister chromatid segregation (GO:0000070)2.90184993
127SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90163654
128nuclear pore organization (GO:0006999)2.89780957
129regulation of cellular amino acid metabolic process (GO:0006521)2.89568551
130kinetochore assembly (GO:0051382)2.89457775
131pore complex assembly (GO:0046931)2.88782651
132histone exchange (GO:0043486)2.88617305
133protein export from nucleus (GO:0006611)2.87847064
134positive regulation of ligase activity (GO:0051351)2.87385150
135pinocytosis (GO:0006907)2.86502648
136negative regulation of chromosome segregation (GO:0051985)2.85621492
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85040037
138translation (GO:0006412)2.84822215
139DNA topological change (GO:0006265)2.84567611
140positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.83856699
141negative regulation of mitotic sister chromatid separation (GO:2000816)2.83435171
142negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83435171
143negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83435171
144negative regulation of sister chromatid segregation (GO:0033046)2.83435171
145* DNA geometric change (GO:0032392)2.83426390
146protein complex localization (GO:0031503)2.83232375
147maturation of 5.8S rRNA (GO:0000460)2.83214524
148pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.82819867
149termination of RNA polymerase III transcription (GO:0006386)2.82226964
150transcription elongation from RNA polymerase III promoter (GO:0006385)2.82226964
151viral mRNA export from host cell nucleus (GO:0046784)2.81469272
152* DNA duplex unwinding (GO:0032508)2.81385603
153tRNA aminoacylation for protein translation (GO:0006418)2.81295356
154basement membrane organization (GO:0071711)2.78614326
155cell-substrate junction assembly (GO:0007044)2.76857203
156mannose metabolic process (GO:0006013)2.76091015
157modulation by symbiont of host cellular process (GO:0044068)2.74297264
158mitotic nuclear envelope reassembly (GO:0007084)2.72742473
159nuclear envelope reassembly (GO:0031468)2.72742473
160regulation of nuclease activity (GO:0032069)2.71853739
161glucose 6-phosphate metabolic process (GO:0051156)2.71149518
162endoplasmic reticulum unfolded protein response (GO:0030968)2.69520957
163regulation of translational termination (GO:0006449)2.65335122
164embryonic process involved in female pregnancy (GO:0060136)2.62820004
165intracellular estrogen receptor signaling pathway (GO:0030520)2.61805408
166ER-nucleus signaling pathway (GO:0006984)2.60932744
167modulation by virus of host process (GO:0019054)2.60913865
168regulation of glucose import in response to insulin stimulus (GO:2001273)2.59816449
169cellular response to epidermal growth factor stimulus (GO:0071364)2.57530402
170protoporphyrinogen IX metabolic process (GO:0046501)2.55086246
171rRNA transcription (GO:0009303)2.53964647
172mitochondrial fusion (GO:0008053)2.53956341
173UV protection (GO:0009650)2.53253027
174establishment of integrated proviral latency (GO:0075713)2.53140381
175vesicle coating (GO:0006901)2.52519386
176chromosome condensation (GO:0030261)2.50790245
177barbed-end actin filament capping (GO:0051016)2.49485491
178regulation of chromatin binding (GO:0035561)2.46813881
179cellular response to unfolded protein (GO:0034620)2.45478048
180intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.45268162
181snRNA metabolic process (GO:0016073)2.44420514
182sister chromatid segregation (GO:0000819)2.43594092
183positive regulation of DNA-dependent DNA replication (GO:2000105)2.42199639
184L-serine metabolic process (GO:0006563)2.41079895
185cytoskeletal anchoring at plasma membrane (GO:0007016)2.40092212

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.72748178
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.23894759
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.90583045
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16150494
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.14299234
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.13056860
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05470303
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95712842
9* EST1_17652178_ChIP-ChIP_JURKAT_Human2.95089090
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.93986963
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90508513
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.83360288
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81672864
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76945320
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.67910283
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63982126
17* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49197922
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35195525
19XRN2_22483619_ChIP-Seq_HELA_Human2.34954370
20* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31677658
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29997668
22VDR_23849224_ChIP-Seq_CD4+_Human2.23725586
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17223387
24ELK3_25401928_ChIP-Seq_HUVEC_Human2.14625572
25LXR_22292898_ChIP-Seq_THP-1_Human2.12356396
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11056296
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09927277
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05782518
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05371882
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03349376
31* DCP1A_22483619_ChIP-Seq_HELA_Human1.97849916
32* FOXP3_21729870_ChIP-Seq_TREG_Human1.97719789
33ZNF263_19887448_ChIP-Seq_K562_Human1.95718079
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95393962
35GABP_19822575_ChIP-Seq_HepG2_Human1.93533930
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89946957
37AR_21909140_ChIP-Seq_LNCAP_Human1.89271601
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88377796
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87798062
40* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85825863
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83696310
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.83626865
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81667523
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80696931
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80229419
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78701597
47RACK7_27058665_Chip-Seq_MCF-7_Human1.76498017
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76326584
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75546537
50CIITA_25753668_ChIP-Seq_RAJI_Human1.74646639
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.74628165
52TTF2_22483619_ChIP-Seq_HELA_Human1.73038278
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.72062503
54MYC_22102868_ChIP-Seq_BL_Human1.71068790
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66622305
56* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62974249
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.62827720
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60392729
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57715697
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.57432494
61TCF7_22412390_ChIP-Seq_EML_Mouse1.56627007
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55115675
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55017812
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52933927
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52215000
66CLOCK_20551151_ChIP-Seq_293T_Human1.49876735
67KDM2B_26808549_Chip-Seq_DND41_Human1.47030956
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46612212
69KDM5A_27292631_Chip-Seq_BREAST_Human1.45469994
70ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.45047519
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43475097
72* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41064781
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.40081165
74ELK1_19687146_ChIP-ChIP_HELA_Human1.39319055
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39124397
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38279864
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.37601497
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37231705
79NCOR1_26117541_ChIP-Seq_K562_Human1.37019535
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36626581
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34996546
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32091603
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31859554
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30646421
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30135765
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28537918
87KDM2B_26808549_Chip-Seq_K562_Human1.27528501
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27226301
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25950443
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.25923395
91P68_20966046_ChIP-Seq_HELA_Human1.24100957
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23296552
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23159365
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22500331
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22390946
96SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22251283
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20468721
98ATF3_27146783_Chip-Seq_COLON_Human1.20454283
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19086041
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18764644
101TFEB_21752829_ChIP-Seq_HELA_Human1.17392310
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16994459
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16973832
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16963864
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15758201
106MAF_26560356_Chip-Seq_TH1_Human1.15675040
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15225356
108CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13525801
109* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13216043
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12779528
111SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12046385
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12011503
113SA1_27219007_Chip-Seq_ERYTHROID_Human1.08202461
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07401090
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07098182
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06834606
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04756636
118RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04637383
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03251429
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03013668
121KDM2B_26808549_Chip-Seq_JURKAT_Human1.02833057
122VDR_21846776_ChIP-Seq_THP-1_Human1.02447653
123MAF_26560356_Chip-Seq_TH2_Human1.02173927
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01549870
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00258573
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00122117
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00023466
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99929013
129SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99628511
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99454604
131CREB1_26743006_Chip-Seq_LNCaP_Human0.99198717
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98014033
133PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97817632
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97495447
135ELF1_20517297_ChIP-Seq_JURKAT_Human0.96898346
136BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96845430
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96817840
138TP53_22127205_ChIP-Seq_IMR90_Human0.96306567
139SMC4_20622854_ChIP-Seq_HELA_Human0.96007042
140UTX_26944678_Chip-Seq_JUKART_Human0.95687743
141* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93192691
142CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92158832
143ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89277461
144* SPI1_23547873_ChIP-Seq_NB4_Human0.87392043
145SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85701824
146* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84920355
147HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83624475
148CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83569937
149MYC_18940864_ChIP-ChIP_HL60_Human0.83515113
150OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83264745
151CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81831511
152SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80826706
153CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80654436
154TCF3_18692474_ChIP-Seq_MEFs_Mouse0.78754869
155NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77519078
156NANOG_21062744_ChIP-ChIP_HESCs_Human0.76886385
157* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76534388

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.52183924
2MP0003111_abnormal_nucleus_morphology4.70249275
3MP0010094_abnormal_chromosome_stability4.56173896
4MP0004957_abnormal_blastocyst_morpholog4.51894947
5MP0003705_abnormal_hypodermis_morpholog4.19049208
6MP0003077_abnormal_cell_cycle3.94582868
7MP0008057_abnormal_DNA_replication3.49273444
8MP0008058_abnormal_DNA_repair3.35223098
9MP0005058_abnormal_lysosome_morphology3.05342405
10MP0008007_abnormal_cellular_replicative3.05224727
11MP0002877_abnormal_melanocyte_morpholog3.01477720
12MP0003806_abnormal_nucleotide_metabolis2.73013662
13MP0005076_abnormal_cell_differentiation2.58936148
14MP0003566_abnormal_cell_adhesion2.45009809
15MP0004185_abnormal_adipocyte_glucose2.41688661
16MP0008932_abnormal_embryonic_tissue2.41293776
17MP0004233_abnormal_muscle_weight2.39803354
18MP0002396_abnormal_hematopoietic_system2.36558896
19MP0001730_embryonic_growth_arrest2.23569471
20MP0003123_paternal_imprinting2.16208613
21MP0000350_abnormal_cell_proliferation2.10179437
22MP0003786_premature_aging2.03165369
23MP0002653_abnormal_ependyma_morphology1.97772408
24MP0008877_abnormal_DNA_methylation1.93109616
25MP0008438_abnormal_cutaneous_collagen1.88630096
26MP0010352_gastrointestinal_tract_polyps1.84937398
27MP0000678_abnormal_parathyroid_gland1.80265347
28MP0003763_abnormal_thymus_physiology1.79833266
29MP0005257_abnormal_intraocular_pressure1.79608219
30MP0002089_abnormal_postnatal_growth/wei1.75446534
31MP0010234_abnormal_vibrissa_follicle1.75196660
32MP0004272_abnormal_basement_membrane1.75034006
33MP0003718_maternal_effect1.72829738
34MP0001348_abnormal_lacrimal_gland1.72639208
35MP0000490_abnormal_crypts_of1.70558376
36MP0004858_abnormal_nervous_system1.65754161
37MP0010307_abnormal_tumor_latency1.63171621
38MP0002080_prenatal_lethality1.62935333
39MP0005380_embryogenesis_phenotype1.60876965
40MP0001672_abnormal_embryogenesis/_devel1.60876965
41MP0003191_abnormal_cellular_cholesterol1.57624831
42MP0001697_abnormal_embryo_size1.56363834
43MP0000003_abnormal_adipose_tissue1.56041347
44MP0000313_abnormal_cell_death1.55255263
45MP0002019_abnormal_tumor_incidence1.54051998
46MP0001661_extended_life_span1.52792717
47MP0003453_abnormal_keratinocyte_physiol1.52498207
48MP0002132_abnormal_respiratory_system1.51020091
49MP0009333_abnormal_splenocyte_physiolog1.49341606
50MP0004808_abnormal_hematopoietic_stem1.48996650
51MP0003984_embryonic_growth_retardation1.44586422
52MP0000537_abnormal_urethra_morphology1.42599604
53MP0000703_abnormal_thymus_morphology1.42155651
54MP0003186_abnormal_redox_activity1.42096624
55MP0002088_abnormal_embryonic_growth/wei1.40630391
56MP0005397_hematopoietic_system_phenotyp1.40444124
57MP0001545_abnormal_hematopoietic_system1.40444124
58MP0003172_abnormal_lysosome_physiology1.39607855
59MP0005666_abnormal_adipose_tissue1.34689239
60MP0002085_abnormal_embryonic_tissue1.34392942
61MP0009840_abnormal_foam_cell1.32966389
62MP0002722_abnormal_immune_system1.31026198
63MP0004264_abnormal_extraembryonic_tissu1.29167250
64MP0003091_abnormal_cell_migration1.28857531
65MP0002086_abnormal_extraembryonic_tissu1.27295448
66MP0002398_abnormal_bone_marrow1.26147732
67MP0005375_adipose_tissue_phenotype1.24984930
68MP0000689_abnormal_spleen_morphology1.23849801
69MP0002796_impaired_skin_barrier1.23566399
70MP0003300_gastrointestinal_ulcer1.23355390
71MP0000358_abnormal_cell_content/1.16986074
72MP0004197_abnormal_fetal_growth/weight/1.16505423
73MP0000733_abnormal_muscle_development1.16397122
74MP0003329_amyloid_beta_deposits1.16023600
75MP0002210_abnormal_sex_determination1.15797093
76MP0008260_abnormal_autophagy1.14196235
77MP0000747_muscle_weakness1.12382867
78MP0002084_abnormal_developmental_patter1.12348674
79MP0002160_abnormal_reproductive_system1.10114998
80MP0005409_darkened_coat_color1.09351189
81MP0009053_abnormal_anal_canal1.08651815
82MP0003567_abnormal_fetal_cardiomyocyte1.08473332
83MP0005623_abnormal_meninges_morphology1.08460702
84MP0000858_altered_metastatic_potential1.07017556
85MP0002060_abnormal_skin_morphology1.05966462
86MP0006036_abnormal_mitochondrial_physio1.04970584
87MP0002429_abnormal_blood_cell1.02931406
88MP0006035_abnormal_mitochondrial_morpho1.02051293
89MP0001764_abnormal_homeostasis1.00571275
90MP0001293_anophthalmia0.98874618
91MP0001853_heart_inflammation0.98802453
92MP0001145_abnormal_male_reproductive0.98664623
93MP0010630_abnormal_cardiac_muscle0.97743558
94MP0003115_abnormal_respiratory_system0.95533802
95MP0003315_abnormal_perineum_morphology0.94949671
96MP0002249_abnormal_larynx_morphology0.94815384
97MP0003385_abnormal_body_wall0.94359880
98MP0006054_spinal_hemorrhage0.92762947
99MP0000759_abnormal_skeletal_muscle0.91229732
100MP0003942_abnormal_urinary_system0.90823184
101MP0004133_heterotaxia0.90544555
102MP0009697_abnormal_copulation0.89970360
103MP0009672_abnormal_birth_weight0.89899629
104MP0009931_abnormal_skin_appearance0.89030853
105MP0000716_abnormal_immune_system0.88891802
106MP0001216_abnormal_epidermal_layer0.88785303
107MP0005389_reproductive_system_phenotype0.87212209
108MP0001119_abnormal_female_reproductive0.86567028
109MP0001929_abnormal_gametogenesis0.84626478
110MP0000750_abnormal_muscle_regeneration0.84194838
111MP0004947_skin_inflammation0.82240786
112MP0004087_abnormal_muscle_fiber0.81906076
113MP0000653_abnormal_sex_gland0.81641574
114MP0000566_synostosis0.81574452
115MP0000751_myopathy0.81310386
116MP0005671_abnormal_response_to0.80664792
117MP0005384_cellular_phenotype0.80065994
118MP0000467_abnormal_esophagus_morphology0.79756221
119MP0001919_abnormal_reproductive_system0.78479645
120MP0003436_decreased_susceptibility_to0.77132613
121MP0002092_abnormal_eye_morphology0.75834409
122MP0003121_genomic_imprinting0.75609285
123MP0001727_abnormal_embryo_implantation0.75258236
124MP0001915_intracranial_hemorrhage0.74977244
125MP0003119_abnormal_digestive_system0.74881656
126MP0002697_abnormal_eye_size0.74015564
127MP0000762_abnormal_tongue_morphology0.73417099
128MP0000428_abnormal_craniofacial_morphol0.73235081
129MP0002111_abnormal_tail_morphology0.71462843
130MP0005621_abnormal_cell_physiology0.70888843
131MP0000609_abnormal_liver_physiology0.70835171
132MP0000598_abnormal_liver_morphology0.70699747
133MP0004147_increased_porphyrin_level0.70596525
134MP0003890_abnormal_embryonic-extraembry0.67870055
135MP0008789_abnormal_olfactory_epithelium0.67757826
136MP0005075_abnormal_melanosome_morpholog0.66803630
137MP0000685_abnormal_immune_system0.66387577
138MP0010030_abnormal_orbit_morphology0.66010580
139MP0001243_abnormal_dermal_layer0.65706315
140MP0002420_abnormal_adaptive_immunity0.64574140
141MP0003941_abnormal_skin_development0.64124014
142MP0001849_ear_inflammation0.63520614
143MP0000477_abnormal_intestine_morphology0.63430311
144MP0001819_abnormal_immune_cell0.63352364
145MP0001800_abnormal_humoral_immune0.62939656
146MP0005266_abnormal_metabolism0.62455936
147MP0005023_abnormal_wound_healing0.60152882
148MP0009703_decreased_birth_body0.60057305
149MP0003221_abnormal_cardiomyocyte_apopto0.60049346
150MP0003656_abnormal_erythrocyte_physiolo0.58979520
151MP0009785_altered_susceptibility_to0.58713125
152MP0005451_abnormal_body_composition0.58436092
153MP0009278_abnormal_bone_marrow0.56540061
154MP0010155_abnormal_intestine_physiology0.55269663
155MP0005501_abnormal_skin_physiology0.54504405

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.39269300
2Breast hypoplasia (HP:0003187)4.53221417
3Abnormality of cells of the erythroid lineage (HP:0012130)4.16572135
4Abnormal number of erythroid precursors (HP:0012131)4.10623082
5Degeneration of anterior horn cells (HP:0002398)4.02438573
6Abnormality of the anterior horn cell (HP:0006802)4.02438573
7Reticulocytopenia (HP:0001896)3.69941403
8Cerebral hypomyelination (HP:0006808)3.65922947
9Hyperacusis (HP:0010780)3.63743963
10Oral leukoplakia (HP:0002745)3.52455127
11Colon cancer (HP:0003003)3.36869827
12Selective tooth agenesis (HP:0001592)3.21136495
13Carpal bone hypoplasia (HP:0001498)3.13755681
14Patellar aplasia (HP:0006443)3.06424556
15Agnosia (HP:0010524)3.03628068
16Premature rupture of membranes (HP:0001788)3.03132126
17Protrusio acetabuli (HP:0003179)3.02604675
18Reticulocytosis (HP:0001923)3.01449054
19Aplastic anemia (HP:0001915)3.00119904
20Insomnia (HP:0100785)3.00083952
21Abnormal gallbladder physiology (HP:0012438)2.95072659
22Cholecystitis (HP:0001082)2.95072659
23Rough bone trabeculation (HP:0100670)2.89967501
24Deep venous thrombosis (HP:0002625)2.87422037
25Microretrognathia (HP:0000308)2.85923314
26Aplasia/Hypoplasia of the patella (HP:0006498)2.85038383
27Macrocytic anemia (HP:0001972)2.82923023
28Ependymoma (HP:0002888)2.79200162
29Vertebral compression fractures (HP:0002953)2.75936573
30Achilles tendon contracture (HP:0001771)2.67138356
31Ulnar bowing (HP:0003031)2.59949906
32Squamous cell carcinoma (HP:0002860)2.58104242
33Microvesicular hepatic steatosis (HP:0001414)2.57296103
34Chromsome breakage (HP:0040012)2.57058519
35Disproportionate tall stature (HP:0001519)2.55286731
36Distal lower limb amyotrophy (HP:0008944)2.55085637
37Multiple enchondromatosis (HP:0005701)2.52749619
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52533337
39Pallor (HP:0000980)2.50626573
40Basal cell carcinoma (HP:0002671)2.50282702
41Medulloblastoma (HP:0002885)2.49985704
42Meckel diverticulum (HP:0002245)2.49668057
43Cellular immunodeficiency (HP:0005374)2.49414628
44Asymmetry of the thorax (HP:0001555)2.48849877
45Abnormality of the Achilles tendon (HP:0005109)2.48799144
46Breech presentation (HP:0001623)2.48642715
47Neoplasm of the pancreas (HP:0002894)2.48361979
48Trismus (HP:0000211)2.47112372
49Impulsivity (HP:0100710)2.46389462
50Atrophy/Degeneration involving motor neurons (HP:0007373)2.46328457
51Abnormality of the preputium (HP:0100587)2.41349227
52Abnormality of the ileum (HP:0001549)2.41044845
53Abnormality of pyrimidine metabolism (HP:0004353)2.39180410
54Type I transferrin isoform profile (HP:0003642)2.39080237
55Absent thumb (HP:0009777)2.38834450
56Myelodysplasia (HP:0002863)2.36712620
57Premature ovarian failure (HP:0008209)2.35935513
58Upper limb amyotrophy (HP:0009129)2.35677304
59Distal upper limb amyotrophy (HP:0007149)2.35677304
60Long palpebral fissure (HP:0000637)2.35271047
61Secondary amenorrhea (HP:0000869)2.34264528
62Flat acetabular roof (HP:0003180)2.32382371
63Type 2 muscle fiber atrophy (HP:0003554)2.32022940
64Centrally nucleated skeletal muscle fibers (HP:0003687)2.31230370
65Rhabdomyosarcoma (HP:0002859)2.30751269
66Megaloblastic anemia (HP:0001889)2.30234017
67Muscle fiber atrophy (HP:0100295)2.29736352
68Back pain (HP:0003418)2.28909116
69Decreased activity of mitochondrial respiratory chain (HP:0008972)2.28532830
70Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.28532830
71Ragged-red muscle fibers (HP:0003200)2.25411137
72Abnormality of the heme biosynthetic pathway (HP:0010472)2.24767297
73Premature graying of hair (HP:0002216)2.24563350
74Bone marrow hypocellularity (HP:0005528)2.24477000
75Combined immunodeficiency (HP:0005387)2.20810825
76Slender long bone (HP:0003100)2.19978809
77Ankyloglossia (HP:0010296)2.19033927
78Renal duplication (HP:0000075)2.15837917
79Increased connective tissue (HP:0009025)2.13772273
803-Methylglutaconic aciduria (HP:0003535)2.12877068
81Progressive external ophthalmoplegia (HP:0000590)2.12592074
82CNS hypomyelination (HP:0003429)2.11306871
83Biconcave vertebral bodies (HP:0004586)2.11279304
84Supernumerary spleens (HP:0009799)2.10086116
85Abnormal lung lobation (HP:0002101)2.09821080
86Severe combined immunodeficiency (HP:0004430)2.09787935
87Horseshoe kidney (HP:0000085)2.09597036
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08561005
89Progressive muscle weakness (HP:0003323)2.08388658
90Abnormal trabecular bone morphology (HP:0100671)2.07971356
91Lymphoma (HP:0002665)2.07601643
92Cerebral aneurysm (HP:0004944)2.07548253
93Aplasia/Hypoplasia of the uvula (HP:0010293)2.06305885
94Thrombocytosis (HP:0001894)2.05217777
95Increased serum lactate (HP:0002151)2.05044737
96Prolonged neonatal jaundice (HP:0006579)2.04953553
97Abnormality of the calcaneus (HP:0008364)2.03531860
98Sparse eyelashes (HP:0000653)2.03509065
99Small intestinal stenosis (HP:0012848)2.03045335
100Duodenal stenosis (HP:0100867)2.03045335
101Abnormality of chromosome stability (HP:0003220)2.02714776
102Metaphyseal cupping (HP:0003021)2.02448596
103Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02276205
104Abnormality of oral frenula (HP:0000190)2.02263153
105Absent radius (HP:0003974)2.01926635
106Pancytopenia (HP:0001876)2.01139801
107T lymphocytopenia (HP:0005403)2.01065018
108Abnormality of the thoracic spine (HP:0100711)1.97167024
109Broad face (HP:0000283)1.96226161
110Granulocytopenia (HP:0001913)1.95929362
111Hypoplasia of the thymus (HP:0000778)1.95894999
112Myopathic facies (HP:0002058)1.95045447
113Poor head control (HP:0002421)1.93454320
114Amaurosis fugax (HP:0100576)1.93139801
115Hemorrhage of the eye (HP:0011885)1.92245879
116Sloping forehead (HP:0000340)1.92004081
117Broad distal phalanx of finger (HP:0009836)1.88747987
118Hyperalaninemia (HP:0003348)1.88142789
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88142789
120Abnormality of alanine metabolism (HP:0010916)1.88142789
121Fragile skin (HP:0001030)1.86678314
122Natal tooth (HP:0000695)1.86630949
123B lymphocytopenia (HP:0010976)1.86315120
124Abnormality of B cell number (HP:0010975)1.86315120
125Pointed chin (HP:0000307)1.86302279
126Thin ribs (HP:0000883)1.85709903
127Abnormality of the umbilical cord (HP:0010881)1.85133188
128Abnormality of reticulocytes (HP:0004312)1.84467672
129Syringomyelia (HP:0003396)1.84264503
130Spinal cord lesions (HP:0100561)1.84264503
131Atresia of the external auditory canal (HP:0000413)1.84140225
132Abnormality of carpal bone ossification (HP:0006257)1.83830940
133Abnormality of DNA repair (HP:0003254)1.83696232
134Abnormality of T cells (HP:0002843)1.83630211
135Absent forearm bone (HP:0003953)1.83293261
136Aplasia involving forearm bones (HP:0009822)1.83293261
137Abnormality of T cell number (HP:0011839)1.82855685
138Spinal rigidity (HP:0003306)1.82764094
139Hand muscle atrophy (HP:0009130)1.82469858
140Tongue fasciculations (HP:0001308)1.81612272
141Abnormal ossification of hand bones (HP:0005921)1.81259973
142Asplenia (HP:0001746)1.80182163
143Hypertensive crisis (HP:0100735)1.79952256
144IgG deficiency (HP:0004315)1.79698189
145Abnormality of the tricuspid valve (HP:0001702)1.79632392
146Petechiae (HP:0000967)1.78897108
147Entropion (HP:0000621)1.78693140
148Patellar dislocation (HP:0002999)1.78375148
149Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77902160
150Mitral regurgitation (HP:0001653)1.77675226
151Postnatal microcephaly (HP:0005484)1.77331632
152Advanced eruption of teeth (HP:0006288)1.75950038
153Nonimmune hydrops fetalis (HP:0001790)1.74976780
154Truncus arteriosus (HP:0001660)1.74832135
155Short nail (HP:0001799)1.74820272
156Overriding aorta (HP:0002623)1.73911117
157Bowel incontinence (HP:0002607)1.73092276
158Cervical subluxation (HP:0003308)1.72700997
159Lower limb amyotrophy (HP:0007210)1.72262606
160Distal lower limb muscle weakness (HP:0009053)1.70775060
161Atrophic scars (HP:0001075)1.70398207
162Blue sclerae (HP:0000592)1.70163200
163Deep palmar crease (HP:0006191)1.69588270
164Orthostatic hypotension (HP:0001278)1.68112125
165Abnormal large intestine physiology (HP:0012700)1.68008720
166Elfin facies (HP:0004428)1.67303655
167Elbow flexion contracture (HP:0002987)1.67008944
168Cholelithiasis (HP:0001081)1.66509509
169Premature skin wrinkling (HP:0100678)1.66316579
170Arnold-Chiari malformation (HP:0002308)1.65674376
171Abnormality of the distal phalanges of the toes (HP:0010182)1.65078870
172Polygenic inheritance (HP:0010982)1.64017213
173Deviation of the thumb (HP:0009603)1.63522107
174Myocardial infarction (HP:0001658)1.63209549
175Increased nuchal translucency (HP:0010880)1.62135251
176Thoracic kyphosis (HP:0002942)1.61659588
177Thin bony cortex (HP:0002753)1.60193680
178Overlapping toe (HP:0001845)1.59708795
179Flared metaphyses (HP:0003015)1.58885885
180Spastic diplegia (HP:0001264)1.58666375
181Abnormality of the acetabulum (HP:0003170)1.58654296
182Generalized amyotrophy (HP:0003700)1.58183745
183Shallow orbits (HP:0000586)1.57995964
184Cerebral inclusion bodies (HP:0100314)1.57430610
185Poikiloderma (HP:0001029)1.56815838
186Cupped ribs (HP:0000887)1.55938110
187Bladder diverticulum (HP:0000015)1.55918821
188Pseudobulbar signs (HP:0002200)1.55173876
189Turricephaly (HP:0000262)1.52590066
190Absent epiphyses (HP:0010577)1.52383396
191Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.52383396
192High anterior hairline (HP:0009890)1.50465713
193Abnormality of glycolysis (HP:0004366)1.49025222
19411 pairs of ribs (HP:0000878)1.48405191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.21794445
2WEE14.18728760
3SMG13.81906004
4EIF2AK13.52807573
5ICK3.47652482
6CDC73.17305867
7NME22.88891917
8SRPK12.73670000
9PRPF4B2.63860625
10TSSK62.62697189
11NEK22.37318487
12ACVR1B2.37246595
13SIK12.29981315
14ERN12.21956420
15TESK22.00441562
16PLK42.00009325
17FGFR41.90013486
18EIF2AK31.89153588
19PLK11.85111633
20RIPK11.83990025
21TTK1.81928596
22PASK1.80201294
23NEK11.77186145
24DYRK31.74705099
25TLK11.66186322
26STK161.65587731
27BRSK21.64893453
28CDK71.63978677
29PDGFRA1.63601922
30TGFBR11.61675164
31MAP2K31.61108332
32FLT31.59086383
33KDR1.59061878
34MKNK11.56886623
35AURKB1.53877457
36RPS6KB21.53033763
37ATR1.52069300
38TTN1.46902379
39ARAF1.46171650
40BCKDK1.46062599
41LATS21.42131471
42RPS6KA41.41699129
43TAOK21.41569499
44EPHA21.40815615
45VRK11.40630062
46AURKA1.38146831
47KSR21.33240502
48PLK31.27693268
49MAP3K81.25934247
50CHEK21.25425555
51EEF2K1.24231782
52SCYL21.18583878
53BRSK11.16598644
54CDK41.15859669
55MTOR1.15443333
56STK101.13774654
57MST1R1.10104810
58MKNK21.08962818
59ZAK1.08338354
60EIF2AK21.05040667
61CHEK11.04862442
62PTK61.02037843
63PIM20.99177332
64PAK40.98532604
65STK40.96672044
66MAP4K10.95019831
67PKN20.93771166
68MAP3K130.93268167
69PTK20.91648878
70NTRK10.90976100
71BMX0.88588684
72VRK20.87483173
73TYRO30.84038892
74ZAP700.83491885
75PNCK0.83282352
76CCNB10.82931056
77SIK20.79411479
78EPHB10.79257577
79MAP3K110.77094558
80PIM10.75795491
81CLK10.75399882
82CDK20.75347862
83MAP2K60.75273880
84CSNK2A20.73056095
85TESK10.69700915
86MARK20.66788595
87CSNK2A10.66748496
88LMTK20.66388462
89ATM0.66366470
90CDK90.65842901
91RAF10.65431271
92BRAF0.64891190
93MAP3K60.64732205
94LRRK20.64262823
95PAK20.64040880
96PDK30.64027323
97PDK40.64027323
98MAP3K10.64012218
99PRKD30.62783523
100PAK10.59593111
101CDK80.59446577
102ALK0.58757616
103MAP3K100.57836281
104MOS0.57664578
105SIK30.57354874
106PDPK10.55785968
107PRKCI0.55518774
108BTK0.54869025
109YES10.54369864
110MET0.54130422
111CDK11A0.53930977
112RPS6KA20.53700585
113CDK120.53597109
114ILK0.52507707
115RPS6KC10.50517006
116RPS6KL10.50517006
117CDK10.49566060
118CDC42BPA0.49248856
119CDK150.48780934
120MAP3K90.48236752
121MAPKAPK30.47363058
122MAP3K140.47328750
123PRKD20.46758979
124IRAK30.44730037
125GRK60.43579131
126RET0.43327793
127CDK180.42272435
128TXK0.41681951
129DDR20.41673106
130AKT30.40339149
131MAP2K20.39955012
132MAPK110.38629497
133RPS6KA50.38497624
134BLK0.37689757
135CDK140.37574166
136CAMK1D0.35252433
137TEC0.35183068
138NLK0.33788773
139NEK90.32149971
140AKT20.30565981
141BRD40.27485568
142TYK20.27411175
143TRIB30.27021917
144DAPK10.26763318
145CDK60.26727737
146JAK30.26278243
147CSNK1E0.26145686
148DYRK20.25700513
149ABL20.25085018
150STK38L0.21988111
151SYK0.21871087
152IKBKB0.21697695

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.74499777
2Mismatch repair_Homo sapiens_hsa034304.27224362
3Proteasome_Homo sapiens_hsa030503.80910084
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.48353114
5Ribosome_Homo sapiens_hsa030103.29390662
6RNA polymerase_Homo sapiens_hsa030203.21045488
7Base excision repair_Homo sapiens_hsa034103.08270537
8Spliceosome_Homo sapiens_hsa030403.07892655
9RNA transport_Homo sapiens_hsa030132.86017926
10* Nucleotide excision repair_Homo sapiens_hsa034202.85140565
11Homologous recombination_Homo sapiens_hsa034402.73784787
12One carbon pool by folate_Homo sapiens_hsa006702.73339816
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67528694
14Other glycan degradation_Homo sapiens_hsa005112.57871844
15Pyrimidine metabolism_Homo sapiens_hsa002402.53844009
16Cell cycle_Homo sapiens_hsa041102.29499649
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90150386
18Fanconi anemia pathway_Homo sapiens_hsa034601.73727603
19Non-small cell lung cancer_Homo sapiens_hsa052231.73426940
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67130114
21Non-homologous end-joining_Homo sapiens_hsa034501.64861538
22RNA degradation_Homo sapiens_hsa030181.59577446
23* Basal transcription factors_Homo sapiens_hsa030221.51900202
24Folate biosynthesis_Homo sapiens_hsa007901.51893040
25Pancreatic cancer_Homo sapiens_hsa052121.51865820
26Sulfur relay system_Homo sapiens_hsa041221.50822137
27Prion diseases_Homo sapiens_hsa050201.47303948
28p53 signaling pathway_Homo sapiens_hsa041151.39462887
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.38556607
30VEGF signaling pathway_Homo sapiens_hsa043701.37432111
31mRNA surveillance pathway_Homo sapiens_hsa030151.34451327
32Purine metabolism_Homo sapiens_hsa002301.31900236
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.31706574
34Endometrial cancer_Homo sapiens_hsa052131.31325229
35Biosynthesis of amino acids_Homo sapiens_hsa012301.31047642
36Notch signaling pathway_Homo sapiens_hsa043301.30359343
37Vitamin B6 metabolism_Homo sapiens_hsa007501.28240076
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.27233021
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25051156
40Pentose phosphate pathway_Homo sapiens_hsa000301.24560134
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17032650
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.16381091
43Insulin signaling pathway_Homo sapiens_hsa049101.09734755
44Epstein-Barr virus infection_Homo sapiens_hsa051691.08760691
45Glioma_Homo sapiens_hsa052141.06856354
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05863505
47Primary immunodeficiency_Homo sapiens_hsa053401.05532852
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05055553
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03442617
50Renal cell carcinoma_Homo sapiens_hsa052111.03219213
51ErbB signaling pathway_Homo sapiens_hsa040121.01966959
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99923655
53Antigen processing and presentation_Homo sapiens_hsa046120.98527943
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.96951091
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96947903
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95373854
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92862909
58Selenocompound metabolism_Homo sapiens_hsa004500.91967378
59B cell receptor signaling pathway_Homo sapiens_hsa046620.91768827
60Carbon metabolism_Homo sapiens_hsa012000.91549719
61Lysine degradation_Homo sapiens_hsa003100.91326967
62Proteoglycans in cancer_Homo sapiens_hsa052050.90781937
63mTOR signaling pathway_Homo sapiens_hsa041500.86386033
64Adherens junction_Homo sapiens_hsa045200.84700638
65Thyroid cancer_Homo sapiens_hsa052160.84198603
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80978324
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79820101
68Focal adhesion_Homo sapiens_hsa045100.79787354
69AMPK signaling pathway_Homo sapiens_hsa041520.78332915
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78309062
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77830774
72Prostate cancer_Homo sapiens_hsa052150.77633769
73Systemic lupus erythematosus_Homo sapiens_hsa053220.76402017
74Arginine biosynthesis_Homo sapiens_hsa002200.76111527
75Herpes simplex infection_Homo sapiens_hsa051680.75625838
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74437616
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72787795
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71856422
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69182513
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67446543
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66694312
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65151380
83* Viral carcinogenesis_Homo sapiens_hsa052030.64064541
84Hepatitis C_Homo sapiens_hsa051600.63920187
85HIF-1 signaling pathway_Homo sapiens_hsa040660.62210362
86Oocyte meiosis_Homo sapiens_hsa041140.61270444
87Fructose and mannose metabolism_Homo sapiens_hsa000510.60420537
88Glutathione metabolism_Homo sapiens_hsa004800.59836218
89Prolactin signaling pathway_Homo sapiens_hsa049170.59199666
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.58429410
91Vibrio cholerae infection_Homo sapiens_hsa051100.56828325
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56748467
93HTLV-I infection_Homo sapiens_hsa051660.55714473
94Legionellosis_Homo sapiens_hsa051340.55688754
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52668986
96Protein export_Homo sapiens_hsa030600.52018502
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51711988
98N-Glycan biosynthesis_Homo sapiens_hsa005100.50985949
99Choline metabolism in cancer_Homo sapiens_hsa052310.48095949
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48012253
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.47761753
102Lysosome_Homo sapiens_hsa041420.46035753
103Amoebiasis_Homo sapiens_hsa051460.45493448
104ECM-receptor interaction_Homo sapiens_hsa045120.45389782
105Insulin resistance_Homo sapiens_hsa049310.44183532
106Endocytosis_Homo sapiens_hsa041440.43838539
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43726694
108Salmonella infection_Homo sapiens_hsa051320.43341812
109Galactose metabolism_Homo sapiens_hsa000520.42309582
110Metabolic pathways_Homo sapiens_hsa011000.40252942
111Shigellosis_Homo sapiens_hsa051310.38135055
112Huntingtons disease_Homo sapiens_hsa050160.37736070
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37033056
114Apoptosis_Homo sapiens_hsa042100.36085743
115Measles_Homo sapiens_hsa051620.34845876
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33896185
117Pyruvate metabolism_Homo sapiens_hsa006200.32899898
118Regulation of autophagy_Homo sapiens_hsa041400.32621928
119Arginine and proline metabolism_Homo sapiens_hsa003300.31676787
120Bladder cancer_Homo sapiens_hsa052190.28171912
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27578825
122Small cell lung cancer_Homo sapiens_hsa052220.26619796
123Parkinsons disease_Homo sapiens_hsa050120.21623528
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.20400009
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.20199117
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19638956
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17862089
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.17757456
129Acute myeloid leukemia_Homo sapiens_hsa052210.17514372
130MicroRNAs in cancer_Homo sapiens_hsa052060.15266094
131Hematopoietic cell lineage_Homo sapiens_hsa046400.14464273
132Vitamin digestion and absorption_Homo sapiens_hsa049770.14385236
133Peroxisome_Homo sapiens_hsa041460.12727177
134Influenza A_Homo sapiens_hsa051640.12635698
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.12359704
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12051903
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10189673
138beta-Alanine metabolism_Homo sapiens_hsa004100.09941013
139Colorectal cancer_Homo sapiens_hsa052100.08714007
140Chronic myeloid leukemia_Homo sapiens_hsa052200.08330330
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.07908490
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.07808492
143Hepatitis B_Homo sapiens_hsa051610.07658442
144Retinol metabolism_Homo sapiens_hsa008300.07362328
145Basal cell carcinoma_Homo sapiens_hsa052170.06127183
146Phenylalanine metabolism_Homo sapiens_hsa003600.05950800
147Arachidonic acid metabolism_Homo sapiens_hsa005900.05947220
148Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05154755
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.04132298

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