GTF2I

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.92713201
2nuclear pore organization (GO:0006999)4.14720518
3pre-miRNA processing (GO:0031054)3.86371290
4DNA unwinding involved in DNA replication (GO:0006268)3.82322383
5regulation of RNA export from nucleus (GO:0046831)3.79084200
6layer formation in cerebral cortex (GO:0021819)3.73969696
7planar cell polarity pathway involved in neural tube closure (GO:0090179)3.68422087
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.62945151
9establishment of nucleus localization (GO:0040023)3.52299843
10peptidyl-lysine dimethylation (GO:0018027)3.50643250
11embryonic foregut morphogenesis (GO:0048617)3.47406704
12pore complex assembly (GO:0046931)3.41891217
13glucocorticoid receptor signaling pathway (GO:0042921)3.41749500
14regulation of nucleobase-containing compound transport (GO:0032239)3.37809003
15cytoskeletal anchoring at plasma membrane (GO:0007016)3.34465900
16insulin-like growth factor receptor signaling pathway (GO:0048009)3.23690461
17embryonic camera-type eye morphogenesis (GO:0048596)3.22690737
18cell communication by electrical coupling (GO:0010644)3.17243376
19mitotic sister chromatid cohesion (GO:0007064)3.16894409
20glial cell proliferation (GO:0014009)3.16269691
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.06409031
22gastrulation with mouth forming second (GO:0001702)3.02979269
23sodium ion export (GO:0071436)3.02950318
24embryonic retina morphogenesis in camera-type eye (GO:0060059)2.99602004
25RNA stabilization (GO:0043489)2.98691694
26mRNA stabilization (GO:0048255)2.98691694
27cytoplasmic mRNA processing body assembly (GO:0033962)2.92195220
28negative regulation of catenin import into nucleus (GO:0035414)2.88242632
29polarized epithelial cell differentiation (GO:0030859)2.87164200
30paraxial mesoderm development (GO:0048339)2.86890573
31dorsal/ventral axis specification (GO:0009950)2.85868520
32epithelial cell differentiation involved in prostate gland development (GO:0060742)2.85158930
33negative regulation of cell size (GO:0045792)2.84460441
34regulation of establishment of planar polarity (GO:0090175)2.81364344
35growth hormone secretion (GO:0030252)2.80985236
36Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.80892497
37spliceosomal tri-snRNP complex assembly (GO:0000244)2.78805320
38stress granule assembly (GO:0034063)2.77554850
39cardiac myofibril assembly (GO:0055003)2.77314563
40mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.76306589
41positive regulation of histone deacetylation (GO:0031065)2.76103528
42nucleosome disassembly (GO:0006337)2.74639014
43protein-DNA complex disassembly (GO:0032986)2.74639014
44DNA topological change (GO:0006265)2.74494221
45positive regulation of glycogen biosynthetic process (GO:0045725)2.73817720
46embryonic eye morphogenesis (GO:0048048)2.71556943
47positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.70633022
48regulation of glucose import in response to insulin stimulus (GO:2001273)2.69107980
49locomotory exploration behavior (GO:0035641)2.66991309
50mitotic chromosome condensation (GO:0007076)2.66356062
51collecting duct development (GO:0072044)2.64869576
52hippo signaling (GO:0035329)2.64260602
53regulation of cardioblast proliferation (GO:0003264)2.64072560
54regulation of secondary heart field cardioblast proliferation (GO:0003266)2.64072560
55membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.63615391
56adherens junction assembly (GO:0034333)2.63167885
57positive regulation of RNA splicing (GO:0033120)2.62623887
58retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.62201394
59synaptic vesicle maturation (GO:0016188)2.61818370
60non-canonical Wnt signaling pathway (GO:0035567)2.60574303
61ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.60382686
62heart morphogenesis (GO:0003007)2.59940459
63establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.59921269
64DNA duplex unwinding (GO:0032508)2.59423405
65positive regulation of hormone biosynthetic process (GO:0046886)2.58463535
66histone H3-K36 demethylation (GO:0070544)2.57865209
67regulation of sister chromatid cohesion (GO:0007063)2.55206865
68eye morphogenesis (GO:0048592)2.53373557
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.51837597
70morphogenesis of an epithelial sheet (GO:0002011)2.51325970
71corticosteroid receptor signaling pathway (GO:0031958)2.50332113
72establishment of spindle orientation (GO:0051294)2.50222123
73semaphorin-plexin signaling pathway (GO:0071526)2.49570377
74regulation of histone H3-K27 methylation (GO:0061085)2.49532144
75ectodermal placode formation (GO:0060788)2.48478267
76camera-type eye morphogenesis (GO:0048593)2.48030640
77protein retention in ER lumen (GO:0006621)2.47863605
78positive regulation of dendritic spine morphogenesis (GO:0061003)2.47823041
79negative regulation of potassium ion transmembrane transport (GO:1901380)2.46843974
80notochord development (GO:0030903)2.46456237
81response to epidermal growth factor (GO:0070849)2.45514494
82DNA geometric change (GO:0032392)2.44490775
83outer ear morphogenesis (GO:0042473)2.43616367
84histone H3-K9 demethylation (GO:0033169)2.43158446
85response to pheromone (GO:0019236)2.43034116
86histone lysine demethylation (GO:0070076)2.42455788
87regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.40810563
88maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.38663823
89plasma membrane repair (GO:0001778)2.37015969
90cellular response to epidermal growth factor stimulus (GO:0071364)2.36901680
91cell migration in hindbrain (GO:0021535)2.36883377
92lateral sprouting from an epithelium (GO:0060601)2.36689414
93membrane repolarization during action potential (GO:0086011)2.36535302
94activation of protein kinase A activity (GO:0034199)2.36521718
95positive regulation of catenin import into nucleus (GO:0035413)2.36253227
96COPI coating of Golgi vesicle (GO:0048205)2.36236618
97Golgi transport vesicle coating (GO:0048200)2.36236618
98ear development (GO:0043583)2.36126916
99innervation (GO:0060384)2.35530071
100positive regulation of dendrite morphogenesis (GO:0050775)2.34704499
101cardiac muscle cell proliferation (GO:0060038)2.34494482
102renal system development (GO:0072001)2.34353452
103cochlea morphogenesis (GO:0090103)2.34282154
104regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.33719395
105auditory behavior (GO:0031223)2.32592314
106establishment of apical/basal cell polarity (GO:0035089)2.32539058
107cell communication involved in cardiac conduction (GO:0086065)2.31761550
108RNA localization (GO:0006403)2.30790675
109nucleus localization (GO:0051647)2.30606151
110midgut development (GO:0007494)2.30491107
111intracellular estrogen receptor signaling pathway (GO:0030520)2.30176527
112protein export from nucleus (GO:0006611)2.29746325
113membrane repolarization (GO:0086009)2.29311943
114dosage compensation (GO:0007549)2.28472201
115body morphogenesis (GO:0010171)2.28444187
116regulation of mRNA stability (GO:0043488)2.28146382
117neural tube development (GO:0021915)2.28000956
118asymmetric protein localization (GO:0008105)2.27717562
119establishment of planar polarity (GO:0001736)2.26487446
120establishment of tissue polarity (GO:0007164)2.26487446
121regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.26066062
122regulation of catenin import into nucleus (GO:0035412)2.25899643
123convergent extension (GO:0060026)2.25857060
124negative regulation of chondrocyte differentiation (GO:0032331)2.24926135
125positive regulation of synapse maturation (GO:0090129)2.23090330
126establishment of mitochondrion localization (GO:0051654)2.22965912
127regulation of glycogen (starch) synthase activity (GO:2000465)2.22635437
128NLS-bearing protein import into nucleus (GO:0006607)2.22424033
129proximal/distal pattern formation (GO:0009954)2.22167679
130positive regulation of glycogen metabolic process (GO:0070875)2.22162023
131regulation of mammary gland epithelial cell proliferation (GO:0033599)2.20978910
132peptidyl-arginine omega-N-methylation (GO:0035247)2.20948089
133establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.20886503
134mitochondrion transport along microtubule (GO:0047497)2.20886503
135establishment of spindle localization (GO:0051293)2.20547883
136negative regulation of sodium ion transport (GO:0010766)2.20024891
137histone demethylation (GO:0016577)2.18866285
138coronary vasculature morphogenesis (GO:0060977)2.16783393
139dendritic spine morphogenesis (GO:0060997)2.16431093
140G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.15965718
141regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.15762290
142negative regulation of histone methylation (GO:0031061)2.15007602
143apical protein localization (GO:0045176)2.14583260
144regulation of translational fidelity (GO:0006450)2.14466667
145regulation of NFAT protein import into nucleus (GO:0051532)2.14273234
146exocrine pancreas development (GO:0031017)2.14159491
147regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.13538243
148regulation of polysaccharide biosynthetic process (GO:0032885)2.13282152
149heterochromatin organization (GO:0070828)2.13272395
150regulation of chromatin binding (GO:0035561)2.12939462
151regulation of mitotic spindle organization (GO:0060236)2.12909792
152cerebellar Purkinje cell layer development (GO:0021680)2.12866400
153peptidyl-arginine methylation (GO:0018216)2.11950619
154peptidyl-arginine N-methylation (GO:0035246)2.11950619
155regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.11875295
156negative regulation of vascular permeability (GO:0043116)2.11482704
157cell-substrate junction assembly (GO:0007044)2.11280703
158cell-substrate adherens junction assembly (GO:0007045)2.11080589
159focal adhesion assembly (GO:0048041)2.11080589

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.50017365
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.80439182
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.06761695
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.05274319
5* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.97334788
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.92490974
7* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.68190277
8* DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.52700849
9* MYC_22102868_ChIP-Seq_BL_Human2.48473506
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.44328565
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42168661
12* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.40933596
13KDM2B_26808549_Chip-Seq_DND41_Human2.40302410
14* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.39214812
15* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.33130211
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24394648
17ESR1_15608294_ChIP-ChIP_MCF-7_Human2.24265244
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22877828
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.21009851
20KDM2B_26808549_Chip-Seq_K562_Human2.15611925
21EZH2_22144423_ChIP-Seq_EOC_Human2.12492128
22TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.10511130
23DROSHA_22980978_ChIP-Seq_HELA_Human1.98482278
24KDM2B_26808549_Chip-Seq_JURKAT_Human1.95983367
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93726552
26TCF7_22412390_ChIP-Seq_EML_Mouse1.91914840
27AR_21909140_ChIP-Seq_LNCAP_Human1.86768377
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85750306
29LXR_22292898_ChIP-Seq_THP-1_Human1.84304026
30* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.82171313
31* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.81343931
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.76791332
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.75757893
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75216821
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.75158352
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.74556119
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.74556119
38* ISL1_27105846_Chip-Seq_CPCs_Mouse1.73904936
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.68548595
40CLOCK_20551151_ChIP-Seq_293T_Human1.65820397
41ZNF263_19887448_ChIP-Seq_K562_Human1.61641972
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59093588
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.58211882
44OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.57448405
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.54738309
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.53880356
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53477973
48CREB1_26743006_Chip-Seq_LNCaP_Human1.52444059
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.49917886
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49273360
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.48570940
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.47628191
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.47503422
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45758655
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45558558
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.44668757
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.44646028
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.44047339
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42984890
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.42540748
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41998335
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40214258
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.40107795
64* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.38710108
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.36527865
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34609015
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.33571167
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32111784
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31606292
70MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31582164
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31143035
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31013513
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30903933
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30738034
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28050348
76FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.27191187
77* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26046781
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.25152637
79SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24505116
80* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23738499
81RACK7_27058665_Chip-Seq_MCF-7_Human1.23715654
82CHD1_26751641_Chip-Seq_LNCaP_Human1.23101137
83* TBX20_22328084_ChIP-Seq_HEART_Mouse1.22874160
84* TBX20_22080862_ChIP-Seq_HEART_Mouse1.22874160
85VDR_21846776_ChIP-Seq_THP-1_Human1.20674748
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20521953
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20137308
88AHR_22903824_ChIP-Seq_MCF-7_Human1.19807080
89* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18326744
90CIITA_25753668_ChIP-Seq_RAJI_Human1.18266754
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18191649
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.16756080
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.16467397
94EED_16625203_ChIP-ChIP_MESCs_Mouse1.16412577
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16274665
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15268432
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.15225862
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13856082
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13644124
100CTCF_27219007_Chip-Seq_Bcells_Human1.12388930
101ESR1_21235772_ChIP-Seq_MCF-7_Human1.12345844
102POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12166959
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12082608
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12050054
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11342500
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11182153
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11102022
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10441225
109* RUNX1_27514584_Chip-Seq_MCF-7_Human1.10084986
110NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09767805
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.09590281
112ESR1_20079471_ChIP-ChIP_T-47D_Human1.09439490
113SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09229810
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08740956
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08579690
116ZNF274_21170338_ChIP-Seq_K562_Hela1.07717626
117FOXM1_23109430_ChIP-Seq_U2OS_Human1.06962360
118PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06710871
119* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05378336
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04150353
121P68_20966046_ChIP-Seq_HELA_Human1.03471550
122* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03165779
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01130924
124TP63_19390658_ChIP-ChIP_HaCaT_Human1.00878353
125* AR_19668381_ChIP-Seq_PC3_Human1.00861040
126PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00428211
127SMC4_20622854_ChIP-Seq_HELA_Human0.99923092
128NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99501615
129* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97716244
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94583144
131MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94467016
132SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93439061
133DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93363025
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93308842
135* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.93208511
136POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92582802
137MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92445849
138* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91656067
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91656040
140REST_18959480_ChIP-ChIP_MESCs_Mouse0.91205703
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.90606982
142* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90590699
143TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89932243
144TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89509829
145AR_21572438_ChIP-Seq_LNCaP_Human0.87153458
146ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86648652
147STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86511588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.25155773
2MP0003122_maternal_imprinting3.22552847
3MP0003283_abnormal_digestive_organ2.97586515
4MP0010030_abnormal_orbit_morphology2.81780916
5MP0002009_preneoplasia2.78628311
6MP0008961_abnormal_basal_metabolism2.33574354
7MP0002234_abnormal_pharynx_morphology2.22965232
8MP0005409_darkened_coat_color2.16877548
9MP0004859_abnormal_synaptic_plasticity2.15975329
10MP0002653_abnormal_ependyma_morphology2.12625549
11MP0003705_abnormal_hypodermis_morpholog2.10990245
12MP0008057_abnormal_DNA_replication2.09196282
13MP0005187_abnormal_penis_morphology2.01151121
14MP0004233_abnormal_muscle_weight1.98529087
15MP0009780_abnormal_chondrocyte_physiolo1.93320630
16MP0003123_paternal_imprinting1.91186514
17MP0003121_genomic_imprinting1.89557644
18MP0004084_abnormal_cardiac_muscle1.85957698
19MP0000534_abnormal_ureter_morphology1.84719191
20MP0005623_abnormal_meninges_morphology1.84425091
21MP0003119_abnormal_digestive_system1.83022287
22MP0003115_abnormal_respiratory_system1.82717346
23MP0003942_abnormal_urinary_system1.81115508
24MP0010352_gastrointestinal_tract_polyps1.78755252
25MP0000428_abnormal_craniofacial_morphol1.75937728
26MP0009053_abnormal_anal_canal1.75643739
27MP0010234_abnormal_vibrissa_follicle1.73172172
28MP0001849_ear_inflammation1.71301868
29MP0000751_myopathy1.63904946
30MP0002877_abnormal_melanocyte_morpholog1.60119565
31MP0004264_abnormal_extraembryonic_tissu1.57491351
32MP0005076_abnormal_cell_differentiation1.56712543
33MP0004858_abnormal_nervous_system1.55082685
34MP0000579_abnormal_nail_morphology1.53889642
35MP0004185_abnormal_adipocyte_glucose1.51331470
36MP0000733_abnormal_muscle_development1.47216650
37MP0002909_abnormal_adrenal_gland1.46349478
38MP0003385_abnormal_body_wall1.45456603
39MP0003935_abnormal_craniofacial_develop1.43645961
40MP0003941_abnormal_skin_development1.43256438
41MP0001299_abnormal_eye_distance/1.37642123
42MP0005248_abnormal_Harderian_gland1.36338046
43MP0003566_abnormal_cell_adhesion1.35355717
44MP0002249_abnormal_larynx_morphology1.34970624
45MP0002084_abnormal_developmental_patter1.33601545
46MP0002932_abnormal_joint_morphology1.32121800
47MP0003111_abnormal_nucleus_morphology1.31853189
48MP0009672_abnormal_birth_weight1.28853063
49MP0003567_abnormal_fetal_cardiomyocyte1.27822324
50MP0010678_abnormal_skin_adnexa1.27320605
51MP0004197_abnormal_fetal_growth/weight/1.27139916
52MP0002089_abnormal_postnatal_growth/wei1.25829229
53MP0003861_abnormal_nervous_system1.25356042
54MP0000383_abnormal_hair_follicle1.22876722
55MP0010630_abnormal_cardiac_muscle1.22388117
56MP0000003_abnormal_adipose_tissue1.21506995
57MP0009384_cardiac_valve_regurgitation1.19255877
58MP0000049_abnormal_middle_ear1.19183851
59MP0002822_catalepsy1.19112791
60MP0004885_abnormal_endolymph1.18528713
61MP0001346_abnormal_lacrimal_gland1.16778736
62MP0006054_spinal_hemorrhage1.16743893
63MP0005257_abnormal_intraocular_pressure1.16382968
64MP0004145_abnormal_muscle_electrophysio1.15556643
65MP0000778_abnormal_nervous_system1.15179578
66MP0004130_abnormal_muscle_cell1.14265785
67MP0009703_decreased_birth_body1.13568680
68MP0008438_abnormal_cutaneous_collagen1.12494657
69MP0010094_abnormal_chromosome_stability1.12409361
70MP0002116_abnormal_craniofacial_bone1.11755825
71MP0009278_abnormal_bone_marrow1.11724232
72MP0002086_abnormal_extraembryonic_tissu1.11380090
73MP0000432_abnormal_head_morphology1.11237342
74MP0008932_abnormal_embryonic_tissue1.10310733
75MP0002085_abnormal_embryonic_tissue1.09685308
76MP0002697_abnormal_eye_size1.09558425
77MP0010368_abnormal_lymphatic_system1.08774536
78MP0000350_abnormal_cell_proliferation1.08704324
79MP0001293_anophthalmia1.08635979
80MP0002837_dystrophic_cardiac_calcinosis1.08124021
81MP0000678_abnormal_parathyroid_gland1.07528777
82MP0003890_abnormal_embryonic-extraembry1.07324120
83MP0002938_white_spotting1.07086982
84MP0000762_abnormal_tongue_morphology1.06788747
85MP0004087_abnormal_muscle_fiber1.06694721
86MP0002098_abnormal_vibrissa_morphology1.06668935
87MP0002233_abnormal_nose_morphology1.05900968
88MP0001270_distended_abdomen1.03987763
89MP0001286_abnormal_eye_development1.03835347
90MP0004270_analgesia1.03731442
91MP0003077_abnormal_cell_cycle1.03492933
92MP0008789_abnormal_olfactory_epithelium1.02466778
93MP0002925_abnormal_cardiovascular_devel1.01716932
94MP0001177_atelectasis1.01554826
95MP0003635_abnormal_synaptic_transmissio1.01240177
96MP0004272_abnormal_basement_membrane1.00845675
97MP0004036_abnormal_muscle_relaxation1.00613327
98MP0000955_abnormal_spinal_cord1.00190674
99MP0001915_intracranial_hemorrhage0.99951744
100MP0002080_prenatal_lethality0.99722391
101MP0000566_synostosis0.99273903
102MP0000631_abnormal_neuroendocrine_gland0.99148787
103MP0003091_abnormal_cell_migration0.98477041
104MP0005394_taste/olfaction_phenotype0.98380117
105MP0005499_abnormal_olfactory_system0.98380117
106MP0004133_heterotaxia0.98185891
107MP0000377_abnormal_hair_follicle0.98110309
108MP0002152_abnormal_brain_morphology0.94975658
109MP0002282_abnormal_trachea_morphology0.94751485
110MP0002896_abnormal_bone_mineralization0.93456303
111MP0005666_abnormal_adipose_tissue0.92571775
112MP0004957_abnormal_blastocyst_morpholog0.92390395
113MP0000266_abnormal_heart_morphology0.92194189
114MP0004811_abnormal_neuron_physiology0.92023820
115MP0002092_abnormal_eye_morphology0.90752689
116MP0002088_abnormal_embryonic_growth/wei0.89188943
117MP0005375_adipose_tissue_phenotype0.89147216
118MP0001730_embryonic_growth_arrest0.88676207
119MP0003937_abnormal_limbs/digits/tail_de0.88372037
120MP0009250_abnormal_appendicular_skeleto0.88322454
121MP0003984_embryonic_growth_retardation0.88141522
122MP0002081_perinatal_lethality0.88118132
123MP0006138_congestive_heart_failure0.87964775
124MP0002184_abnormal_innervation0.87364238
125MP0002108_abnormal_muscle_morphology0.87162436
126MP0002111_abnormal_tail_morphology0.85521141
127MP0006072_abnormal_retinal_apoptosis0.85078576
128MP0003755_abnormal_palate_morphology0.85046521
129MP0001672_abnormal_embryogenesis/_devel0.84750326
130MP0005380_embryogenesis_phenotype0.84750326
131MP0001340_abnormal_eyelid_morphology0.84494776
132MP0003137_abnormal_impulse_conducting0.84282065
133MP0001697_abnormal_embryo_size0.84098116
134MP0004215_abnormal_myocardial_fiber0.83317061
135MP0005275_abnormal_skin_tensile0.82681818
136MP0002796_impaired_skin_barrier0.82568339
137MP0003938_abnormal_ear_development0.82150176
138MP0003787_abnormal_imprinting0.80489317
139MP0002114_abnormal_axial_skeleton0.79168714
140MP0000462_abnormal_digestive_system0.78769729
141MP0000747_muscle_weakness0.77186626

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.80322181
2Short 4th metacarpal (HP:0010044)3.80322181
3* Hyperacusis (HP:0010780)3.67083880
4Abnormality of the 4th metacarpal (HP:0010012)3.37732750
5* Renal duplication (HP:0000075)3.30025156
6Neoplasm of the heart (HP:0100544)3.06068602
7Shallow orbits (HP:0000586)3.04032537
8Broad metatarsal (HP:0001783)2.83587541
9Lymphangioma (HP:0100764)2.82976130
10* Elfin facies (HP:0004428)2.75574552
11Macroorchidism (HP:0000053)2.71913443
12* Insomnia (HP:0100785)2.70688488
13Enlarged penis (HP:0000040)2.60545351
14* Pointed chin (HP:0000307)2.59466466
15Cerebral aneurysm (HP:0004944)2.57375325
16High anterior hairline (HP:0009890)2.53267190
17* Renovascular hypertension (HP:0100817)2.45234306
18Heterotopia (HP:0002282)2.42518175
19Vertebral arch anomaly (HP:0008438)2.42423236
20Trigonocephaly (HP:0000243)2.36001375
21Ankyloglossia (HP:0010296)2.34754756
22* Overriding aorta (HP:0002623)2.31073827
23* Increased nuchal translucency (HP:0010880)2.30138251
24Cortical dysplasia (HP:0002539)2.28977642
25Termporal pattern (HP:0011008)2.27041492
26Insidious onset (HP:0003587)2.27041492
27Papillary thyroid carcinoma (HP:0002895)2.25966100
28Abnormality of the lower motor neuron (HP:0002366)2.21738403
29Rectal prolapse (HP:0002035)2.17880932
30Subacute progressive viral hepatitis (HP:0006572)2.16681423
31Aplasia involving bones of the extremities (HP:0009825)2.16291751
32Aplasia involving bones of the upper limbs (HP:0009823)2.16291751
33Aplasia of the phalanges of the hand (HP:0009802)2.16291751
34Abnormality of the distal phalanx of the thumb (HP:0009617)2.13398003
35Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.13213679
36* Bowel diverticulosis (HP:0005222)2.12496246
37Dysmetric saccades (HP:0000641)2.11055863
38Deep philtrum (HP:0002002)2.08633705
39* Obsessive-compulsive behavior (HP:0000722)2.08583966
40Ependymoma (HP:0002888)2.08258350
41Back pain (HP:0003418)2.05445317
42Broad face (HP:0000283)2.05262289
43Ulnar bowing (HP:0003031)2.05161974
44Protrusio acetabuli (HP:0003179)2.03864888
45Buphthalmos (HP:0000557)2.00755508
46Annular pancreas (HP:0001734)1.99432631
47Abnormality of oral frenula (HP:0000190)1.99190150
48Turricephaly (HP:0000262)1.98032419
49Advanced eruption of teeth (HP:0006288)1.97392565
50Abnormality of the astrocytes (HP:0100707)1.97114137
51Astrocytoma (HP:0009592)1.97114137
52* Bladder diverticulum (HP:0000015)1.93785348
53* Sacral dimple (HP:0000960)1.91697683
54Syringomyelia (HP:0003396)1.91411855
55Spinal cord lesions (HP:0100561)1.91411855
56Flat acetabular roof (HP:0003180)1.90925016
57Aneurysm (HP:0002617)1.90194043
58Broad palm (HP:0001169)1.90064747
59* Flat cornea (HP:0007720)1.88737499
60Germ cell neoplasia (HP:0100728)1.87738900
61Broad thumb (HP:0011304)1.87135975
62Scapular winging (HP:0003691)1.85932315
63Exostoses (HP:0100777)1.85588243
64Narrow palate (HP:0000189)1.85148671
65Cutaneous syndactyly (HP:0012725)1.85044234
66* Deviation of the hallux (HP:0010051)1.84896408
67Hepatoblastoma (HP:0002884)1.82633801
68Hammertoe (HP:0001765)1.82195666
69Ventricular fibrillation (HP:0001663)1.81898891
70Hypoplastic labia majora (HP:0000059)1.80697452
71Leiomyosarcoma (HP:0100243)1.79526085
72Uterine leiomyosarcoma (HP:0002891)1.79526085
73Short phalanx of the thumb (HP:0009660)1.79346447
74Pseudobulbar signs (HP:0002200)1.77738759
75* Hallux valgus (HP:0001822)1.77022013
76Alacrima (HP:0000522)1.76878444
77Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75815886
78Fibroma (HP:0010614)1.75038863
79Bronchomalacia (HP:0002780)1.75009817
80Abnormality of the fingertips (HP:0001211)1.75003211
81Aortic aneurysm (HP:0004942)1.74205588
82* Abnormality of the diencephalon (HP:0010662)1.72947398
83Absent frontal sinuses (HP:0002688)1.72219041
84Fibrous tissue neoplasm (HP:0012316)1.71924097
85Malignant gastrointestinal tract tumors (HP:0006749)1.70899705
86Gastrointestinal carcinoma (HP:0002672)1.70899705
87Megalencephaly (HP:0001355)1.69461601
88Overgrowth (HP:0001548)1.69329257
89Hypoventilation (HP:0002791)1.69202517
90Mitral valve prolapse (HP:0001634)1.68859349
91Deviation of the thumb (HP:0009603)1.68461666
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68128590
93Striae distensae (HP:0001065)1.68084591
94Midline defect of the nose (HP:0004122)1.67727238
95Volvulus (HP:0002580)1.67560156
96Omphalocele (HP:0001539)1.67385503
97Skull defect (HP:0001362)1.66584212
98Intestinal polyp (HP:0005266)1.66042158
99Transitional cell carcinoma of the bladder (HP:0006740)1.65829021
100Disproportionate tall stature (HP:0001519)1.65510356
101Thin bony cortex (HP:0002753)1.64687793
102Hypopigmentation of the fundus (HP:0007894)1.64463369
103Abnormality of the calcaneus (HP:0008364)1.63935795
104Cutaneous finger syndactyly (HP:0010554)1.62850233
105Distal upper limb amyotrophy (HP:0007149)1.62526254
106Upper limb amyotrophy (HP:0009129)1.62526254
107Hand muscle atrophy (HP:0009130)1.62475096
108Abnormality of the labia majora (HP:0012881)1.62055887
109Choanal stenosis (HP:0000452)1.61775489
110* Spina bifida occulta (HP:0003298)1.61522307
111Sudden death (HP:0001699)1.61375788
112Limited elbow extension (HP:0001377)1.61123252
113Long toe (HP:0010511)1.61001750
114Proximal placement of thumb (HP:0009623)1.60829627
115Ankle contracture (HP:0006466)1.60473320
116Aplasia/Hypoplasia of the sternum (HP:0006714)1.60417603
117Anal stenosis (HP:0002025)1.59681099
118* Precocious puberty (HP:0000826)1.59326385
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59302695
120Overlapping toe (HP:0001845)1.59169949
121Missing ribs (HP:0000921)1.59099414
122Abnormality of the left ventricular outflow tract (HP:0011103)1.58993925
123Subaortic stenosis (HP:0001682)1.58993925
124Long eyelashes (HP:0000527)1.58980502
125Increased variability in muscle fiber diameter (HP:0003557)1.58855184
126Congenital glaucoma (HP:0001087)1.58822153
127Thyroid carcinoma (HP:0002890)1.58504805
128* Arnold-Chiari malformation (HP:0002308)1.58293683
129Bicuspid aortic valve (HP:0001647)1.57996314
130Broad phalanges of the hand (HP:0009768)1.57515937
131Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.57125201
132Depression (HP:0000716)1.56863572
133Hypercortisolism (HP:0001578)1.55771058
134Broad finger (HP:0001500)1.55434719
135Skin tags (HP:0010609)1.54929738
136Coronal craniosynostosis (HP:0004440)1.54675487
137Cubitus valgus (HP:0002967)1.53979456
138* Megalocornea (HP:0000485)1.53815062
139Asymmetry of the thorax (HP:0001555)1.53761066
140Sandal gap (HP:0001852)1.53697507
141Nephroblastoma (Wilms tumor) (HP:0002667)1.53266526
142Tracheomalacia (HP:0002779)1.52467955
143Relative macrocephaly (HP:0004482)1.51949943
144Arterial tortuosity (HP:0005116)1.51786656
145Intestinal polyposis (HP:0200008)1.51697194
146Colon cancer (HP:0003003)1.50986289
147Neonatal short-limb short stature (HP:0008921)1.50808203
148Supernumerary ribs (HP:0005815)1.50656880
149Neonatal hypoglycemia (HP:0001998)1.50504193
150Bladder neoplasm (HP:0009725)1.50213538
151Bladder carcinoma (HP:0002862)1.50213538
152Visceral angiomatosis (HP:0100761)1.50004585
153Open mouth (HP:0000194)1.49331510
154Thick eyebrow (HP:0000574)1.49281964
155Limb-girdle muscle atrophy (HP:0003797)1.49221915
156Bundle branch block (HP:0011710)1.48763501
157Broad phalanx (HP:0006009)1.48531586
158* Patellar dislocation (HP:0002999)1.47684702
159Midface retrusion (HP:0011800)1.46945667
160Medulloblastoma (HP:0002885)1.46681273
161Hemangiomatosis (HP:0007461)1.45351718
162Vascular tortuosity (HP:0004948)1.45267213

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.17007742
2PKN23.86332443
3MAP3K102.95831799
4EEF2K2.82342540
5PRKD32.61776690
6SMG12.59329480
7ICK2.54466471
8RIPK12.37399387
9PDGFRA2.18727245
10PTK62.16606103
11TYRO31.86524994
12PASK1.69065272
13SIK11.64985553
14NEK11.58836802
15CDK121.56003899
16TTN1.54950474
17UHMK11.50676487
18CAMK1G1.44095857
19LMTK21.41676337
20FGFR21.40626852
21EPHB21.39396393
22RET1.35562957
23PAK61.33881272
24DMPK1.32320043
25NTRK21.28479691
26FGFR11.27811398
27BCR1.27382165
28DDR21.27056719
29ALK1.24648765
30BRD41.24389087
31LATS11.23397106
32MTOR1.22867739
33PAK41.19670596
34SCYL21.16389463
35SRPK11.14902897
36KSR11.14886897
37MAP3K71.11758063
38AKT31.11191274
39ERBB21.09241978
40MET1.04578472
41PDGFRB1.04407910
42PTK21.04028663
43PRKCH1.02653074
44MKNK11.01980966
45TGFBR11.00819562
46STK381.00692271
47NTRK31.00083410
48CAMKK10.98516242
49KSR20.97762614
50LATS20.97166113
51PAK30.94556014
52CAMK1D0.94438329
53PRPF4B0.94302721
54PAK20.93478691
55NEK90.90704707
56HIPK20.90203077
57MINK10.90031111
58PHKG10.89344528
59PHKG20.89344528
60EPHA30.88058181
61TTK0.87059312
62EPHA20.86723271
63NEK60.86476937
64MAP3K90.85733257
65CDK70.84187847
66TAOK10.83959810
67MAP3K20.83494533
68CDC42BPA0.82624930
69CDK60.80686094
70LRRK20.79863527
71FER0.78047371
72CASK0.76096439
73FGFR40.75597610
74WNK40.74797195
75MARK20.74581437
76MARK10.73846562
77SGK20.73559741
78DAPK20.71651951
79RPS6KB10.71599548
80WNK10.70906155
81DYRK1B0.70010949
82SGK2230.69830207
83SGK4940.69830207
84FGFR30.68661471
85MAP3K40.67698411
86SIK20.66193612
87BMX0.65917567
88TSSK60.65620828
89NEK20.64932983
90PRKD10.61775494
91ILK0.60751979
92CHEK10.60353046
93ATR0.59901152
94NTRK10.59351815
95* CDK20.58944025
96CDK10.57643018
97RPS6KB20.57466613
98CSNK1A1L0.57038044
99CDK150.56240176
100FLT30.56037540
101ATM0.54703957
102CDK180.54630666
103PRKD20.52675802
104RPS6KA20.52654575
105CDK90.52385553
106CDK11A0.51461608
107MST1R0.51156678
108MAP3K60.49783698
109GSK3B0.49716000
110PRKAA10.49216655
111SGK30.48616844
112MAPK150.48557506
113TIE10.48130720
114AKT20.47999356
115YES10.47659988
116MKNK20.47297626
117CDK140.46264914
118ERN10.46141561
119MAP2K20.45975250
120STK38L0.45861671
121DYRK1A0.44660466
122MAPK140.44468425
123CDK50.43886693
124ROCK20.43652535
125STK110.43333415
126CDC70.42769850
127ERBB40.41809839
128MAPK90.41405341
129MELK0.41116655
130CAMK40.41013938
131ROCK10.40517000
132CHEK20.40504549
133CSNK1E0.39883870
134CDK40.38679471
135MAPK100.38237706
136PNCK0.37997928
137CSNK1G20.36845810
138PTK2B0.36193841
139PRKDC0.35506765
140* SRC0.34739159
141MAPK80.34310468
142PDK30.33960699

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.23301542
2Hedgehog signaling pathway_Homo sapiens_hsa043401.79568644
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.76211461
4Nitrogen metabolism_Homo sapiens_hsa009101.63664737
5Hippo signaling pathway_Homo sapiens_hsa043901.61777991
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60464569
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57858743
8Notch signaling pathway_Homo sapiens_hsa043301.53097041
9Insulin secretion_Homo sapiens_hsa049111.51898860
10Endometrial cancer_Homo sapiens_hsa052131.50662291
11Lysine degradation_Homo sapiens_hsa003101.48828663
12Thyroid hormone signaling pathway_Homo sapiens_hsa049191.42410670
13mTOR signaling pathway_Homo sapiens_hsa041501.42048366
14Melanogenesis_Homo sapiens_hsa049161.42040775
15Chronic myeloid leukemia_Homo sapiens_hsa052201.41395520
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40221356
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.39805930
18Circadian entrainment_Homo sapiens_hsa047131.36491747
19Type II diabetes mellitus_Homo sapiens_hsa049301.35697846
20Wnt signaling pathway_Homo sapiens_hsa043101.35129318
21Dilated cardiomyopathy_Homo sapiens_hsa054141.34775882
22Colorectal cancer_Homo sapiens_hsa052101.33250169
23Prostate cancer_Homo sapiens_hsa052151.33161841
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30251277
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30014196
26Gastric acid secretion_Homo sapiens_hsa049711.29346048
27Adherens junction_Homo sapiens_hsa045201.29285735
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.28723000
29Estrogen signaling pathway_Homo sapiens_hsa049151.27479087
30Choline metabolism in cancer_Homo sapiens_hsa052311.25065096
31Long-term potentiation_Homo sapiens_hsa047201.23076701
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22496626
33Axon guidance_Homo sapiens_hsa043601.20506794
34Gap junction_Homo sapiens_hsa045401.19359183
35Proteoglycans in cancer_Homo sapiens_hsa052051.19241044
36Glioma_Homo sapiens_hsa052141.18977251
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.17893968
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17819304
39Glucagon signaling pathway_Homo sapiens_hsa049221.17816012
40Focal adhesion_Homo sapiens_hsa045101.16370196
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15456305
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13872020
43Dopaminergic synapse_Homo sapiens_hsa047281.13769599
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13723955
45Dorso-ventral axis formation_Homo sapiens_hsa043201.13334396
46Cell cycle_Homo sapiens_hsa041101.13150778
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13069498
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12320602
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.12192350
50Non-small cell lung cancer_Homo sapiens_hsa052231.11711629
51Insulin resistance_Homo sapiens_hsa049311.08670737
52Renin secretion_Homo sapiens_hsa049241.07662083
53Inositol phosphate metabolism_Homo sapiens_hsa005621.07387120
54mRNA surveillance pathway_Homo sapiens_hsa030151.06487129
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06460337
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05867844
57Insulin signaling pathway_Homo sapiens_hsa049101.05349660
58Acute myeloid leukemia_Homo sapiens_hsa052211.04684203
59Cholinergic synapse_Homo sapiens_hsa047251.04283514
60Amphetamine addiction_Homo sapiens_hsa050311.03988882
61Cocaine addiction_Homo sapiens_hsa050301.03504418
62* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02592420
63Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00485169
64VEGF signaling pathway_Homo sapiens_hsa043700.98959191
65Olfactory transduction_Homo sapiens_hsa047400.98845611
66Tight junction_Homo sapiens_hsa045300.98552449
67Oxytocin signaling pathway_Homo sapiens_hsa049210.98514639
68Thyroid cancer_Homo sapiens_hsa052160.97583088
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97400837
70Oocyte meiosis_Homo sapiens_hsa041140.96964551
71Biosynthesis of amino acids_Homo sapiens_hsa012300.96716259
72Renal cell carcinoma_Homo sapiens_hsa052110.96180785
73AMPK signaling pathway_Homo sapiens_hsa041520.94707868
74GnRH signaling pathway_Homo sapiens_hsa049120.93445603
75GABAergic synapse_Homo sapiens_hsa047270.92699455
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91858133
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91519892
78Glutamatergic synapse_Homo sapiens_hsa047240.91232647
79Melanoma_Homo sapiens_hsa052180.90868738
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88381255
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87964294
82Rap1 signaling pathway_Homo sapiens_hsa040150.87683237
83ErbB signaling pathway_Homo sapiens_hsa040120.85171387
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84730053
85cAMP signaling pathway_Homo sapiens_hsa040240.84571274
86Thyroid hormone synthesis_Homo sapiens_hsa049180.82038978
87Salivary secretion_Homo sapiens_hsa049700.81345633
88MicroRNAs in cancer_Homo sapiens_hsa052060.80736855
89Pentose phosphate pathway_Homo sapiens_hsa000300.79779917
90ECM-receptor interaction_Homo sapiens_hsa045120.76214181
91Pathways in cancer_Homo sapiens_hsa052000.76046100
92Viral myocarditis_Homo sapiens_hsa054160.75980207
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.74637275
94Non-homologous end-joining_Homo sapiens_hsa034500.74164177
95Morphine addiction_Homo sapiens_hsa050320.73643379
96Bladder cancer_Homo sapiens_hsa052190.71180517
97Protein digestion and absorption_Homo sapiens_hsa049740.69907847
98Pancreatic cancer_Homo sapiens_hsa052120.68433002
99Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68013158
100Small cell lung cancer_Homo sapiens_hsa052220.67407886
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67029880
102Alcoholism_Homo sapiens_hsa050340.66696747
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66165727
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65996654
105FoxO signaling pathway_Homo sapiens_hsa040680.65572361
106Pancreatic secretion_Homo sapiens_hsa049720.64929270
107HTLV-I infection_Homo sapiens_hsa051660.64879883
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63495723
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63057202
110Synaptic vesicle cycle_Homo sapiens_hsa047210.62812573
111TGF-beta signaling pathway_Homo sapiens_hsa043500.62579551
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62496551
113Platelet activation_Homo sapiens_hsa046110.62349348
114Prolactin signaling pathway_Homo sapiens_hsa049170.62093111
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.61427968
116Bile secretion_Homo sapiens_hsa049760.60547312
117N-Glycan biosynthesis_Homo sapiens_hsa005100.60409925
118Long-term depression_Homo sapiens_hsa047300.59620054
119Endocytosis_Homo sapiens_hsa041440.59595918
120Viral carcinogenesis_Homo sapiens_hsa052030.58548423
121RNA transport_Homo sapiens_hsa030130.57618501
122Spliceosome_Homo sapiens_hsa030400.56997461
123Steroid biosynthesis_Homo sapiens_hsa001000.55662867
124Prion diseases_Homo sapiens_hsa050200.55054785
125Carbon metabolism_Homo sapiens_hsa012000.54213731
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.53185722
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.51041104
128DNA replication_Homo sapiens_hsa030300.48441543
129Amoebiasis_Homo sapiens_hsa051460.48364601
130HIF-1 signaling pathway_Homo sapiens_hsa040660.47807131

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