GTF2IP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.26278563
2presynaptic membrane assembly (GO:0097105)4.42286595
3presynaptic membrane organization (GO:0097090)4.41194916
4neuron cell-cell adhesion (GO:0007158)4.33917069
5postsynaptic membrane organization (GO:0001941)4.32254916
6behavioral response to nicotine (GO:0035095)4.16360209
7nucleobase catabolic process (GO:0046113)4.13395630
8cerebral cortex radially oriented cell migration (GO:0021799)4.03542911
9central nervous system myelination (GO:0022010)3.98876160
10axon ensheathment in central nervous system (GO:0032291)3.98876160
11neuron recognition (GO:0008038)3.94631856
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87086217
13axonal fasciculation (GO:0007413)3.84391719
14dendritic spine morphogenesis (GO:0060997)3.83769645
15cell migration in hindbrain (GO:0021535)3.83476004
16auditory behavior (GO:0031223)3.81332611
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.50767522
18mechanosensory behavior (GO:0007638)3.50385105
19protein localization to synapse (GO:0035418)3.46227053
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.44300391
21transmission of nerve impulse (GO:0019226)3.44099553
22vocalization behavior (GO:0071625)3.38616466
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32611913
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.30204591
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.25078942
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.22849107
27substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.20150767
28substrate-independent telencephalic tangential migration (GO:0021826)3.20150767
29retinal ganglion cell axon guidance (GO:0031290)3.13147347
30establishment of mitochondrion localization (GO:0051654)3.11298806
31neurotransmitter-gated ion channel clustering (GO:0072578)3.10305807
32exploration behavior (GO:0035640)3.06915424
33dendrite morphogenesis (GO:0048813)3.04659344
34cerebellar granule cell differentiation (GO:0021707)3.02987009
35regulation of synapse structural plasticity (GO:0051823)3.02933687
36positive regulation of gastrulation (GO:2000543)3.02748508
37epithelial cilium movement (GO:0003351)3.00919274
38gamma-aminobutyric acid transport (GO:0015812)2.98821578
39synaptic transmission, glutamatergic (GO:0035249)2.97426987
40adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.96799573
41synapse assembly (GO:0007416)2.94087439
42cochlea development (GO:0090102)2.93963250
43central nervous system projection neuron axonogenesis (GO:0021952)2.90485726
44synaptic vesicle maturation (GO:0016188)2.90022080
45positive regulation of synapse assembly (GO:0051965)2.90009447
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89682818
47limb bud formation (GO:0060174)2.88987306
48spinal cord development (GO:0021510)2.87993436
49locomotory exploration behavior (GO:0035641)2.87437835
50glutamate receptor signaling pathway (GO:0007215)2.87308933
51neuron fate determination (GO:0048664)2.84669024
52axonemal dynein complex assembly (GO:0070286)2.83613972
53cell proliferation in forebrain (GO:0021846)2.83361221
54response to auditory stimulus (GO:0010996)2.82032986
55otic vesicle formation (GO:0030916)2.79716297
56regulation of short-term neuronal synaptic plasticity (GO:0048172)2.79379951
57nonmotile primary cilium assembly (GO:0035058)2.78855524
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.78641270
59positive regulation of dendritic spine morphogenesis (GO:0061003)2.77804767
60cilium movement (GO:0003341)2.77758774
61neuronal action potential propagation (GO:0019227)2.76519088
62forebrain neuron differentiation (GO:0021879)2.75486987
63establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.75143736
64mitochondrion transport along microtubule (GO:0047497)2.75143736
65neuronal ion channel clustering (GO:0045161)2.74448140
66regulation of glutamate receptor signaling pathway (GO:1900449)2.74368883
67behavioral response to cocaine (GO:0048148)2.72797837
68adult walking behavior (GO:0007628)2.71424826
69neuron-neuron synaptic transmission (GO:0007270)2.70805672
70membrane depolarization during action potential (GO:0086010)2.69291853
71axon extension (GO:0048675)2.63769628
72dopaminergic neuron differentiation (GO:0071542)2.63326786
73cell differentiation in hindbrain (GO:0021533)2.63220605
74short-term memory (GO:0007614)2.62015298
75somite development (GO:0061053)2.57326464
76synaptic vesicle exocytosis (GO:0016079)2.56588071
77cerebellar Purkinje cell differentiation (GO:0021702)2.56497131
78neuronal stem cell maintenance (GO:0097150)2.55268402
79neuron migration (GO:0001764)2.54919972
80regulation of synaptic vesicle exocytosis (GO:2000300)2.53803406
81synapse organization (GO:0050808)2.48112801
82positive regulation of dendritic spine development (GO:0060999)2.47484690
83negative regulation of axonogenesis (GO:0050771)2.47202202
84prepulse inhibition (GO:0060134)2.46377379
85negative regulation of glial cell differentiation (GO:0045686)2.45612447
86neurotransmitter secretion (GO:0007269)2.44238792
87negative regulation of astrocyte differentiation (GO:0048712)2.44031394
88cerebral cortex cell migration (GO:0021795)2.43745722
89dendrite development (GO:0016358)2.43417970
90regulation of collateral sprouting (GO:0048670)2.43274593
91negative regulation of axon extension (GO:0030517)2.42100902
92regulation of neurotransmitter uptake (GO:0051580)2.41202222
93nephron tubule morphogenesis (GO:0072078)2.41198712
94nephron epithelium morphogenesis (GO:0072088)2.41198712
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.40929333
96regulation of synaptic vesicle transport (GO:1902803)2.40163150
97startle response (GO:0001964)2.40132944
98positive regulation of meiosis (GO:0045836)2.39514258
99neurofilament cytoskeleton organization (GO:0060052)2.38715596
100regulation of dendritic spine morphogenesis (GO:0061001)2.38000297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.90109416
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.23990534
3EZH2_27304074_Chip-Seq_ESCs_Mouse2.77496765
4GBX2_23144817_ChIP-Seq_PC3_Human2.69770489
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66746030
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.57509593
7REST_21632747_ChIP-Seq_MESCs_Mouse2.46235118
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37655783
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35719814
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32418819
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.30091116
12RNF2_27304074_Chip-Seq_ESCs_Mouse2.28768595
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24766989
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20610790
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20610790
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19767980
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.17098771
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15575560
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11285799
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08819920
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06882621
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95227977
23BMI1_23680149_ChIP-Seq_NPCS_Mouse1.94795483
24RNF2_27304074_Chip-Seq_NSC_Mouse1.93841618
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93255453
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93178531
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92388014
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85945698
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84338793
30VDR_22108803_ChIP-Seq_LS180_Human1.81619338
31DROSHA_22980978_ChIP-Seq_HELA_Human1.80004680
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.77934100
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73094210
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72794293
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72610348
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.71378855
37RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.70693580
38ZNF274_21170338_ChIP-Seq_K562_Hela1.70638190
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68377223
40TAF15_26573619_Chip-Seq_HEK293_Human1.64724603
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62571579
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62083239
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62083239
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56353963
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.54326477
46AR_21572438_ChIP-Seq_LNCaP_Human1.48984813
47IGF1R_20145208_ChIP-Seq_DFB_Human1.46899758
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46750865
49P300_19829295_ChIP-Seq_ESCs_Human1.43135269
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39219900
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.37744826
52FUS_26573619_Chip-Seq_HEK293_Human1.36057476
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34470495
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34196900
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.33192398
56SMAD4_21799915_ChIP-Seq_A2780_Human1.32925765
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29723523
58KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27888202
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.25304854
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24434543
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23443022
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22644744
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21376909
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19099601
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17871093
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.17505459
67AR_25329375_ChIP-Seq_VCAP_Human1.16025958
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13151255
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13069463
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.11423202
71EWS_26573619_Chip-Seq_HEK293_Human1.10030494
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07285092
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06345946
74STAT3_23295773_ChIP-Seq_U87_Human1.06009429
75STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05868508
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05588904
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.05407583
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.05347392
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05091814
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04894667
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.04158881
82ER_23166858_ChIP-Seq_MCF-7_Human1.03605143
83SMAD3_21741376_ChIP-Seq_ESCs_Human1.03519517
84RUNX2_22187159_ChIP-Seq_PCA_Human1.03375785
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03260921
86BCAT_22108803_ChIP-Seq_LS180_Human1.03037271
87* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01852209
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01236670
89TCF4_23295773_ChIP-Seq_U87_Human1.01170313
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00182571
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97938471
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97172265
93AR_19668381_ChIP-Seq_PC3_Human0.96005774
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94475017
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.94407729
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93530372
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92728502
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92579132
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.91917682
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.88933426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.20142632
2MP0004859_abnormal_synaptic_plasticity2.98623801
3MP0003122_maternal_imprinting2.90142577
4MP0006292_abnormal_olfactory_placode2.87851524
5MP0003787_abnormal_imprinting2.68890108
6MP0000778_abnormal_nervous_system2.65162352
7MP0004885_abnormal_endolymph2.60592010
8MP0009379_abnormal_foot_pigmentation2.56115081
9MP0005423_abnormal_somatic_nervous2.47608244
10MP0003635_abnormal_synaptic_transmissio2.36874510
11MP0000566_synostosis2.27033767
12MP0004270_analgesia2.21631273
13MP0002822_catalepsy2.12703632
14MP0009745_abnormal_behavioral_response2.08288357
15MP0003121_genomic_imprinting2.04620658
16MP0001486_abnormal_startle_reflex2.03270198
17MP0002063_abnormal_learning/memory/cond1.98340761
18MP0002272_abnormal_nervous_system1.97448103
19MP0002064_seizures1.95151412
20MP0002653_abnormal_ependyma_morphology1.90734110
21MP0003123_paternal_imprinting1.84213802
22MP0002572_abnormal_emotion/affect_behav1.83893804
23MP0002734_abnormal_mechanical_nocicepti1.83751341
24MP0006276_abnormal_autonomic_nervous1.82424632
25MP0002735_abnormal_chemical_nociception1.81946158
26MP0004742_abnormal_vestibular_system1.80815093
27MP0003890_abnormal_embryonic-extraembry1.78624664
28MP0004133_heterotaxia1.78112635
29MP0001968_abnormal_touch/_nociception1.74379877
30MP0002638_abnormal_pupillary_reflex1.70884251
31MP0009046_muscle_twitch1.70627920
32MP0000631_abnormal_neuroendocrine_gland1.69754456
33MP0000955_abnormal_spinal_cord1.68108439
34MP0001188_hyperpigmentation1.67955422
35MP0002557_abnormal_social/conspecific_i1.64911635
36MP0001440_abnormal_grooming_behavior1.63626263
37MP0004142_abnormal_muscle_tone1.59223394
38MP0002736_abnormal_nociception_after1.57221639
39MP0001485_abnormal_pinna_reflex1.57008034
40MP0003136_yellow_coat_color1.56773156
41MP0002067_abnormal_sensory_capabilities1.53963230
42MP0003938_abnormal_ear_development1.53518411
43MP0002184_abnormal_innervation1.52826013
44MP0002733_abnormal_thermal_nociception1.49071215
45MP0001970_abnormal_pain_threshold1.46805835
46MP0003283_abnormal_digestive_organ1.45404980
47MP0001984_abnormal_olfaction1.45193752
48MP0008877_abnormal_DNA_methylation1.43789207
49MP0005499_abnormal_olfactory_system1.41429701
50MP0005394_taste/olfaction_phenotype1.41429701
51MP0001529_abnormal_vocalization1.39937473
52MP0002882_abnormal_neuron_morphology1.39171458
53MP0005551_abnormal_eye_electrophysiolog1.37924003
54MP0003878_abnormal_ear_physiology1.37524168
55MP0005377_hearing/vestibular/ear_phenot1.37524168
56MP0000049_abnormal_middle_ear1.36083380
57MP0008789_abnormal_olfactory_epithelium1.32952546
58MP0002938_white_spotting1.30502705
59MP0001905_abnormal_dopamine_level1.28762981
60MP0005646_abnormal_pituitary_gland1.28109313
61MP0002152_abnormal_brain_morphology1.27572346
62MP0000026_abnormal_inner_ear1.26604216
63MP0004811_abnormal_neuron_physiology1.25759288
64MP0002752_abnormal_somatic_nervous1.23562563
65MP0001293_anophthalmia1.16540978
66MP0003861_abnormal_nervous_system1.16101787
67MP0004924_abnormal_behavior1.14587035
68MP0005386_behavior/neurological_phenoty1.14587035
69MP0003119_abnormal_digestive_system1.14128382
70MP0002909_abnormal_adrenal_gland1.09727715
71MP0008569_lethality_at_weaning1.08956894
72MP0001963_abnormal_hearing_physiology1.05311997
73MP0004145_abnormal_muscle_electrophysio1.04166413
74MP0002928_abnormal_bile_duct1.02926206
75MP0002066_abnormal_motor_capabilities/c1.02525752
76MP0001502_abnormal_circadian_rhythm1.02380579
77MP0002102_abnormal_ear_morphology1.02227761
78MP0003011_delayed_dark_adaptation0.98631958
79MP0005195_abnormal_posterior_eye0.98553501
80MP0010030_abnormal_orbit_morphology0.98030517
81MP0005645_abnormal_hypothalamus_physiol0.92981965
82MP0001286_abnormal_eye_development0.90835650
83MP0002233_abnormal_nose_morphology0.88995462
84MP0003937_abnormal_limbs/digits/tail_de0.88014058
85MP0003942_abnormal_urinary_system0.87823165
86MP0000569_abnormal_digit_pigmentation0.87083715
87MP0003879_abnormal_hair_cell0.85062039
88MP0005187_abnormal_penis_morphology0.83521423
89MP0001986_abnormal_taste_sensitivity0.82345449
90MP0003633_abnormal_nervous_system0.82193185
91MP0006072_abnormal_retinal_apoptosis0.81731146
92MP0005084_abnormal_gallbladder_morpholo0.81533912
93MP0008872_abnormal_physiological_respon0.79230686
94MP0002069_abnormal_eating/drinking_beha0.78807166
95MP0002277_abnormal_respiratory_mucosa0.78079391
96MP0005253_abnormal_eye_physiology0.74283932
97MP0002751_abnormal_autonomic_nervous0.73132324
98MP0002229_neurodegeneration0.71725996
99MP0003631_nervous_system_phenotype0.71548256
100MP0002116_abnormal_craniofacial_bone0.71095043

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.63558822
2Focal motor seizures (HP:0011153)3.97818380
3Limb dystonia (HP:0002451)3.71454117
4Progressive cerebellar ataxia (HP:0002073)3.48482352
5Focal seizures (HP:0007359)3.38187598
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.35287359
7Absent/shortened dynein arms (HP:0200106)3.35287359
8Abnormal ciliary motility (HP:0012262)2.99349434
9True hermaphroditism (HP:0010459)2.97292134
10Nephronophthisis (HP:0000090)2.96787426
11Abnormal respiratory motile cilium morphology (HP:0005938)2.93812106
12Abnormal respiratory epithelium morphology (HP:0012253)2.93812106
13Febrile seizures (HP:0002373)2.89924125
14Septo-optic dysplasia (HP:0100842)2.80271822
15Molar tooth sign on MRI (HP:0002419)2.74564359
16Abnormality of midbrain morphology (HP:0002418)2.74564359
17Pancreatic fibrosis (HP:0100732)2.74271139
18Abnormal respiratory motile cilium physiology (HP:0012261)2.69944825
19Polyphagia (HP:0002591)2.67147061
20Epileptic encephalopathy (HP:0200134)2.65393124
21Gait imbalance (HP:0002141)2.58095840
22Abnormality of the renal medulla (HP:0100957)2.54180645
23Drooling (HP:0002307)2.51679419
24Broad-based gait (HP:0002136)2.46086234
25Medial flaring of the eyebrow (HP:0010747)2.45151414
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.44622227
27Pancreatic cysts (HP:0001737)2.41841816
28Atonic seizures (HP:0010819)2.37745467
29Megalencephaly (HP:0001355)2.36712187
30Oligodactyly (hands) (HP:0001180)2.35364559
31Genetic anticipation (HP:0003743)2.32329836
32Hyperventilation (HP:0002883)2.31950363
33Abnormality of the labia minora (HP:0012880)2.30556376
34Agitation (HP:0000713)2.29846017
35Excessive salivation (HP:0003781)2.29382233
36Hepatoblastoma (HP:0002884)2.21686257
37Anophthalmia (HP:0000528)2.21265156
38Nephrogenic diabetes insipidus (HP:0009806)2.21258070
39Hemiparesis (HP:0001269)2.20088485
40Optic nerve hypoplasia (HP:0000609)2.19423516
41Chronic hepatic failure (HP:0100626)2.16575473
42Type II lissencephaly (HP:0007260)2.16279856
43Lissencephaly (HP:0001339)2.14917766
44Abnormal eating behavior (HP:0100738)2.14419652
45Amblyopia (HP:0000646)2.14215743
46Sleep apnea (HP:0010535)2.13331131
47Vaginal atresia (HP:0000148)2.10648878
48Genital tract atresia (HP:0001827)2.09835675
49Rib fusion (HP:0000902)2.05518276
50Action tremor (HP:0002345)2.04711944
51Cystic liver disease (HP:0006706)2.04530944
52Congenital primary aphakia (HP:0007707)2.04232752
53Abnormality of the corticospinal tract (HP:0002492)2.03293811
54Specific learning disability (HP:0001328)2.00768696
55Anencephaly (HP:0002323)1.97512209
56Oligodactyly (HP:0012165)1.96743687
57Pachygyria (HP:0001302)1.96594064
58Dialeptic seizures (HP:0011146)1.94445293
59Abnormality of the aortic arch (HP:0012303)1.91721312
60Rhinitis (HP:0012384)1.90365323
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.88050144
62Generalized tonic-clonic seizures (HP:0002069)1.87475724
63Abnormality of the diencephalon (HP:0010662)1.85949839
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85773969
65Degeneration of the lateral corticospinal tracts (HP:0002314)1.85773969
66Cutaneous finger syndactyly (HP:0010554)1.84705667
67Abnormal drinking behavior (HP:0030082)1.84516769
68Polydipsia (HP:0001959)1.84516769
6911 pairs of ribs (HP:0000878)1.83236434
70Abnormal rod and cone electroretinograms (HP:0008323)1.82266314
71Absence seizures (HP:0002121)1.80910707
72Abnormality of binocular vision (HP:0011514)1.76617269
73Diplopia (HP:0000651)1.76617269
74Growth hormone deficiency (HP:0000824)1.76512151
75Maternal diabetes (HP:0009800)1.75105230
76Cerebellar dysplasia (HP:0007033)1.71815157
77Sclerocornea (HP:0000647)1.71679483
78Esophageal atresia (HP:0002032)1.70910237
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69518836
80Abnormality of the 4th metacarpal (HP:0010012)1.69199941
81Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69197887
82Short 4th metacarpal (HP:0010044)1.69197887
83Morphological abnormality of the pyramidal tract (HP:0002062)1.69102981
84Congenital stationary night blindness (HP:0007642)1.68527291
85Bilateral microphthalmos (HP:0007633)1.67862705
86Impaired vibration sensation in the lower limbs (HP:0002166)1.67670372
87Absent septum pellucidum (HP:0001331)1.67396249
88Cutaneous syndactyly (HP:0012725)1.67275440
89Poor coordination (HP:0002370)1.65663301
90Chronic bronchitis (HP:0004469)1.63380720
91Intestinal atresia (HP:0011100)1.62889503
92Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.62472552
93Male pseudohermaphroditism (HP:0000037)1.61972764
94Abnormal hair whorl (HP:0010721)1.61971800
95Polyuria (HP:0000103)1.61849704
96Status epilepticus (HP:0002133)1.61551548
97Midline defect of the nose (HP:0004122)1.61501338
98Postaxial hand polydactyly (HP:0001162)1.61094072
99Shawl scrotum (HP:0000049)1.60729621
100Renal hypoplasia (HP:0000089)1.56120841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.71598971
2CASK4.08727124
3PNCK3.47996595
4TNIK2.88806009
5NTRK32.87376283
6NTRK22.57377416
7WNK32.55207606
8DYRK22.41496734
9MAPK152.27618674
10EPHA42.17065801
11MAPK131.98110126
12UHMK11.96310454
13MAP3K41.87045867
14SIK21.81524589
15TYRO31.80465258
16EPHB21.72367024
17BMPR1B1.70031004
18SGK4941.56431741
19SGK2231.56431741
20MINK11.55167817
21PINK11.53473301
22SGK21.39090848
23FGFR21.38098419
24PRKCG1.36935991
25MAP2K71.33959865
26ADRBK21.31986923
27CAMKK11.28653768
28WEE11.27045476
29DAPK21.26364273
30PAK31.24067821
31MAP2K41.22226947
32WNK41.18314610
33CDK191.16283602
34CSNK1G21.10584413
35DYRK31.07706155
36DYRK1A1.05570068
37MAP3K91.04768794
38GRK11.02536448
39CDK51.01094058
40MKNK21.00438626
41CAMK1G0.97801860
42STK110.94861034
43DYRK1B0.94602025
44PAK60.93553812
45PASK0.89908634
46CDK30.87480593
47CAMK10.86941578
48PHKG10.83155047
49PHKG20.83155047
50ACVR1B0.81114474
51SGK10.79881361
52FRK0.76455890
53OXSR10.76265610
54INSRR0.75890153
55MARK20.74602495
56WNK10.74005376
57NTRK10.72320299
58NUAK10.71705802
59PKN10.70724905
60BCR0.69009771
61BRSK20.65786405
62SGK30.65344214
63PRKCZ0.63314220
64CSNK1G10.62868070
65MAP3K70.61939820
66DMPK0.60753838
67PRKG10.59975669
68ERBB20.58220777
69CAMK2A0.57938872
70CSNK1E0.56175278
71KSR10.55285010
72STK160.54341866
73PRKCH0.53126043
74PIK3CA0.53038623
75BRSK10.51566576
76CSNK1G30.50673791
77FGFR10.49983725
78VRK10.47411195
79PLK20.46931091
80STK390.46816162
81PRKACA0.45465635
82IRAK20.45332400
83PRKCE0.45293330
84CAMK2B0.44778244
85MKNK10.44680040
86CAMK40.43785049
87NEK20.41259935
88YES10.41229387
89CAMKK20.39791452
90TAF10.38740595
91PRKD30.35412719
92RPS6KA30.35323931
93MAPKAPK50.35153036
94CSNK1D0.34974157
95CDK150.34699556
96CDK11A0.34139203
97ADRBK10.33583204
98GRK50.33461804
99CDK140.33213179
100MAP3K20.31963013

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77667082
2Glutamatergic synapse_Homo sapiens_hsa047242.38026812
3Cocaine addiction_Homo sapiens_hsa050302.31755321
4Morphine addiction_Homo sapiens_hsa050322.23417338
5Circadian entrainment_Homo sapiens_hsa047132.20754480
6GABAergic synapse_Homo sapiens_hsa047272.15114381
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12036328
8Cardiac muscle contraction_Homo sapiens_hsa042602.08676885
9Dopaminergic synapse_Homo sapiens_hsa047282.08474832
10Insulin secretion_Homo sapiens_hsa049112.05821002
11Phototransduction_Homo sapiens_hsa047442.03582117
12Amphetamine addiction_Homo sapiens_hsa050311.98236444
13Axon guidance_Homo sapiens_hsa043601.78628856
14Oxidative phosphorylation_Homo sapiens_hsa001901.76055912
15Cholinergic synapse_Homo sapiens_hsa047251.66555055
16Ribosome_Homo sapiens_hsa030101.62700573
17Basal cell carcinoma_Homo sapiens_hsa052171.61338398
18Serotonergic synapse_Homo sapiens_hsa047261.58115197
19Taste transduction_Homo sapiens_hsa047421.58072020
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55620227
21Parkinsons disease_Homo sapiens_hsa050121.51922692
22Synaptic vesicle cycle_Homo sapiens_hsa047211.51905375
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.44599858
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43227738
25Olfactory transduction_Homo sapiens_hsa047401.41205690
26Hedgehog signaling pathway_Homo sapiens_hsa043401.34907260
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33043030
28Long-term depression_Homo sapiens_hsa047301.32684372
29Long-term potentiation_Homo sapiens_hsa047201.32261149
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30443678
31Gastric acid secretion_Homo sapiens_hsa049711.29459735
32cAMP signaling pathway_Homo sapiens_hsa040241.26350220
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25901295
34Dorso-ventral axis formation_Homo sapiens_hsa043201.21308502
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21199248
36Alzheimers disease_Homo sapiens_hsa050101.17747202
37Wnt signaling pathway_Homo sapiens_hsa043101.15511265
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14970534
39Oxytocin signaling pathway_Homo sapiens_hsa049211.14491344
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.10347129
41Huntingtons disease_Homo sapiens_hsa050161.10204286
42Melanogenesis_Homo sapiens_hsa049161.10124268
43Linoleic acid metabolism_Homo sapiens_hsa005911.08269592
44Butanoate metabolism_Homo sapiens_hsa006501.06988752
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05285966
46Gap junction_Homo sapiens_hsa045401.04362453
47Salivary secretion_Homo sapiens_hsa049701.03808341
48Renin secretion_Homo sapiens_hsa049240.93191887
49Hippo signaling pathway_Homo sapiens_hsa043900.92940639
50Calcium signaling pathway_Homo sapiens_hsa040200.90162424
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88525401
52Regulation of autophagy_Homo sapiens_hsa041400.87130100
53Nitrogen metabolism_Homo sapiens_hsa009100.86038900
54Histidine metabolism_Homo sapiens_hsa003400.85408741
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84339192
56Ether lipid metabolism_Homo sapiens_hsa005650.83183209
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82221243
58Estrogen signaling pathway_Homo sapiens_hsa049150.80971279
59Bile secretion_Homo sapiens_hsa049760.80400771
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76718408
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75682617
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73652425
63Thyroid hormone synthesis_Homo sapiens_hsa049180.72645283
64Notch signaling pathway_Homo sapiens_hsa043300.70302051
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70009383
66Ras signaling pathway_Homo sapiens_hsa040140.69577192
67beta-Alanine metabolism_Homo sapiens_hsa004100.69330234
68MAPK signaling pathway_Homo sapiens_hsa040100.68558342
69Protein export_Homo sapiens_hsa030600.66758638
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65850938
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65411129
72Pancreatic secretion_Homo sapiens_hsa049720.64272038
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63874291
74Steroid biosynthesis_Homo sapiens_hsa001000.63432281
75ErbB signaling pathway_Homo sapiens_hsa040120.62584890
76Ovarian steroidogenesis_Homo sapiens_hsa049130.61926190
77Type II diabetes mellitus_Homo sapiens_hsa049300.61777093
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.61714530
79GnRH signaling pathway_Homo sapiens_hsa049120.60280030
80Rap1 signaling pathway_Homo sapiens_hsa040150.59782088
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59146433
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55485867
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54085301
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51965181
85Collecting duct acid secretion_Homo sapiens_hsa049660.49829443
86Retinol metabolism_Homo sapiens_hsa008300.48480504
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48086489
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47591595
89Tryptophan metabolism_Homo sapiens_hsa003800.46783238
90Alcoholism_Homo sapiens_hsa050340.46601470
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.45712020
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.45358098
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.44365537
94Dilated cardiomyopathy_Homo sapiens_hsa054140.44052705
95Propanoate metabolism_Homo sapiens_hsa006400.43739028
96Chemical carcinogenesis_Homo sapiens_hsa052040.42955606
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42872053
98Glycerolipid metabolism_Homo sapiens_hsa005610.42543964
99ABC transporters_Homo sapiens_hsa020100.40470937
100Tight junction_Homo sapiens_hsa045300.40031407

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