ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	9.37324824
2	protein targeting to Golgi (GO:0000042)	8.59018950
3	establishment of protein localization to Golgi (GO:0072600)	8.44251112
4	chromosome condensation (GO:0030261)	8.07775026
5	retrograde transport, vesicle recycling within Golgi (GO:0000301)	8.01839371
6	DNA packaging (GO:0006323)	7.83262602
7	response to pheromone (GO:0019236)	7.52769478
8	single strand break repair (GO:0000012)	7.52539688
9	protein polyglutamylation (GO:0018095)	7.42199274
10	spermatid development (GO:0007286)	7.37787420
11	microtubule depolymerization (GO:0007019)	7.35879664
12	sperm capacitation (GO:0048240)	7.29023752
13	plasma membrane fusion (GO:0045026)	7.05707728
14	spermatid nucleus differentiation (GO:0007289)	7.00547329
15	microtubule polymerization or depolymerization (GO:0031109)	6.75888362
16	centriole replication (GO:0007099)	6.59111577
17	sperm-egg recognition (GO:0035036)	6.57623030
18	rRNA methylation (GO:0031167)	6.57087841
19	multicellular organism reproduction (GO:0032504)	6.57043635
20	protein localization to Golgi apparatus (GO:0034067)	6.33886478
21	spermatogenesis (GO:0007283)	6.05190764
22	male gamete generation (GO:0048232)	6.03891027
23	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.95118226
24	reproduction (GO:0000003)	5.90819076
25	seminiferous tubule development (GO:0072520)	5.82794883
26	axonemal dynein complex assembly (GO:0070286)	5.80619892
27	binding of sperm to zona pellucida (GO:0007339)	5.70536027
28	calcium ion-dependent exocytosis (GO:0017156)	5.63105108
29	centriole assembly (GO:0098534)	5.62448551
30	phosphatidylethanolamine metabolic process (GO:0046337)	5.57551584
31	gamete generation (GO:0007276)	5.55318696
32	cilium or flagellum-dependent cell motility (GO:0001539)	5.52311128
33	regulation of centriole replication (GO:0046599)	5.44614140
34	cell-cell recognition (GO:0009988)	5.44160120
35	rRNA modification (GO:0000154)	5.39989134
36	regulation of cilium movement (GO:0003352)	5.18262615
37	RNA destabilization (GO:0050779)	5.11395579
38	single fertilization (GO:0007338)	5.04446800
39	microtubule severing (GO:0051013)	5.01476933
40	sexual reproduction (GO:0019953)	4.99399100
41	motile cilium assembly (GO:0044458)	4.95714400
42	negative regulation of inclusion body assembly (GO:0090084)	4.95591979
43	glomerular visceral epithelial cell development (GO:0072015)	4.76658283
44	regulation of Rab GTPase activity (GO:0032313)	4.71597956
45	positive regulation of Rab GTPase activity (GO:0032851)	4.71597956
46	microtubule nucleation (GO:0007020)	4.66959040
47	epithelial cilium movement (GO:0003351)	4.64136771
48	cellular ketone body metabolic process (GO:0046950)	4.62081852
49	fertilization (GO:0009566)	4.44295279
50	multicellular organismal reproductive process (GO:0048609)	4.40309295
51	glomerular epithelial cell development (GO:0072310)	4.38958801
52	germ cell development (GO:0007281)	4.30540365
53	cell wall macromolecule catabolic process (GO:0016998)	4.20003809
54	cilium movement (GO:0003341)	4.10530488
55	musculoskeletal movement (GO:0050881)	4.10264732
56	multicellular organismal movement (GO:0050879)	4.10264732
57	chromatin silencing (GO:0006342)	4.05115025
58	ketone body metabolic process (GO:1902224)	4.04080946
59	cell wall macromolecule metabolic process (GO:0044036)	4.03563422
60	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.98249835
61	nucleus organization (GO:0006997)	3.89111291
62	glycerol ether metabolic process (GO:0006662)	3.65890774
63	regulation of transcription involved in cell fate commitment (GO:0060850)	3.62592128
64	coenzyme catabolic process (GO:0009109)	3.57913246
65	intra-Golgi vesicle-mediated transport (GO:0006891)	3.55626276
66	piRNA metabolic process (GO:0034587)	3.50611437
67	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.44659239
68	organic cation transport (GO:0015695)	3.42448591
69	negative regulation of Rho protein signal transduction (GO:0035024)	3.40921144
70	ether metabolic process (GO:0018904)	3.35135932
71	regulation of inclusion body assembly (GO:0090083)	3.28787842
72	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.19259359
73	DNA methylation involved in gamete generation (GO:0043046)	3.17951437
74	regulation of microtubule-based movement (GO:0060632)	3.14791552
75	nuclear pore complex assembly (GO:0051292)	3.12921650
76	axoneme assembly (GO:0035082)	3.12480916
77	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.99516872
78	ventricular system development (GO:0021591)	2.95681262
79	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.89771117
80	negative regulation of gene expression, epigenetic (GO:0045814)	2.86844081
81	multicellular organismal development (GO:0007275)	2.85613917
82	male meiosis (GO:0007140)	2.85361228
83	peptidyl-threonine dephosphorylation (GO:0035970)	2.79557307
84	male meiosis I (GO:0007141)	2.79310530
85	Golgi to endosome transport (GO:0006895)	2.71056789
86	membrane protein intracellular domain proteolysis (GO:0031293)	2.71037799
87	regulation of meiosis I (GO:0060631)	2.70640173
88	cell recognition (GO:0008037)	2.67685020
89	vesicle transport along microtubule (GO:0047496)	2.67046658
90	nucleosome disassembly (GO:0006337)	2.65660763
91	protein-DNA complex disassembly (GO:0032986)	2.65660763
92	histone mRNA catabolic process (GO:0071044)	2.65363900
93	histone H3-K9 demethylation (GO:0033169)	2.65023164
94	regulation of centrosome duplication (GO:0010824)	2.64655681
95	cilium organization (GO:0044782)	2.63900621
96	spinal cord motor neuron differentiation (GO:0021522)	2.63361496
97	cilium assembly (GO:0042384)	2.62359420
98	protein K48-linked deubiquitination (GO:0071108)	2.60861889
99	sperm motility (GO:0030317)	11.1527720
100	acrosome reaction (GO:0007340)	10.1928782

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.81023925
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.15670249
3	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.71421207
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.71421207
5	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.57999952
6	FUS_26573619_Chip-Seq_HEK293_Human	2.48398178
7	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.47974212
8	CBP_20019798_ChIP-Seq_JUKART_Human	2.47974212
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.42551303
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.40194389
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.32218467
12	ER_23166858_ChIP-Seq_MCF-7_Human	2.15596581
13	EZH2_22144423_ChIP-Seq_EOC_Human	1.94342839
14	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.91210858
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.89818373
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.81923488
17	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78471901
18	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.78287377
19	P300_19829295_ChIP-Seq_ESCs_Human	1.76158558
20	DROSHA_22980978_ChIP-Seq_HELA_Human	1.75432682
21	ERA_21632823_ChIP-Seq_H3396_Human	1.70417896
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.69712027
23	VDR_22108803_ChIP-Seq_LS180_Human	1.69004361
24	RAC3_21632823_ChIP-Seq_H3396_Human	1.68606421
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.68294113
26	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.67500826
27	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.62467872
28	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.61797842
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.59631665
30	AR_25329375_ChIP-Seq_VCAP_Human	1.59459243
31	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.58831760
32	GBX2_23144817_ChIP-Seq_PC3_Human	1.55306344
33	NANOG_20526341_ChIP-Seq_ESCs_Human	1.52296911
34	STAT3_23295773_ChIP-Seq_U87_Human	1.50106258
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.50081425
36	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.49943366
37	MYC_19829295_ChIP-Seq_ESCs_Human	1.48203227
38	AR_21572438_ChIP-Seq_LNCaP_Human	1.42948721
39	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.42839433
40	ETV1_20927104_ChIP-Seq_GIST48_Human	1.40281271
41	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.40038120
42	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.37543428
43	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.37270609
44	RBPJ_21746931_ChIP-Seq_IB4_Human	1.36410041
45	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.36234995
46	SMAD4_21799915_ChIP-Seq_A2780_Human	1.35808247
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35466609
48	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.35384588
49	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.35328039
50	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.33866019
51	OCT4_20526341_ChIP-Seq_ESCs_Human	1.32198961
52	TBL1_22424771_ChIP-Seq_293T_Human	1.31471430
53	NFYB_21822215_ChIP-Seq_K562_Human	1.30821308
54	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.30396118
55	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.30319896
56	TAF2_19829295_ChIP-Seq_ESCs_Human	1.30136591
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.30124854
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.29352884
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29231075
60	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.28627624
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28475677
62	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.28422379
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27723860
64	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27723860
65	CEBPB_22108803_ChIP-Seq_LS180_Human	1.27075745
66	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.26093844
67	TP53_18474530_ChIP-ChIP_U2OS_Human	1.24638765
68	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.24562976
69	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.22847834
70	RUNX_20019798_ChIP-Seq_JUKART_Human	1.22639145
71	PHF8_20622853_ChIP-Seq_HELA_Human	1.21144617
72	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.21046787
73	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.20384864
74	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.19531341
75	ERG_20517297_ChIP-Seq_VCAP_Human	1.19325277
76	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.18040521
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.17453448
78	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17077129
79	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.16374425
80	TCF4_23295773_ChIP-Seq_U87_Human	1.14534196
81	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.14153536
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.14129463
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12460049
84	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.10398989
85	AHR_22903824_ChIP-Seq_MCF-7_Human	1.10035904
86	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.09939345
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09720439
88	KDM2B_26808549_Chip-Seq_REH_Human	1.08943799
89	NFYA_21822215_ChIP-Seq_K562_Human	1.08284324
90	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07881225
91	SMRT_27268052_Chip-Seq_Bcells_Human	1.07846709
92	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.06545596
93	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.04564339
94	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.02902674
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02648450
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02648450
97	E2F1_20622854_ChIP-Seq_HELA_Human	1.02604431
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00723730
99	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00497994
100	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.00387906

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	5.27817318
2	MP0005377_hearing/vestibular/ear_phenot	5.27817318
3	MP0005670_abnormal_white_adipose	4.34857581
4	MP0003698_abnormal_male_reproductive	4.07988172
5	MP0001929_abnormal_gametogenesis	3.59964948
6	MP0001348_abnormal_lacrimal_gland	3.16102264
7	MP0003646_muscle_fatigue	2.83915207
8	MP0002161_abnormal_fertility/fecundity	2.12457821
9	MP0003718_maternal_effect	2.06730844
10	MP0003011_delayed_dark_adaptation	2.02672444
11	MP0005410_abnormal_fertilization	10.5985328
12	MP0001486_abnormal_startle_reflex	1.93665532
13	MP0001485_abnormal_pinna_reflex	1.86805637
14	MP0005379_endocrine/exocrine_gland_phen	1.83745491
15	MP0002132_abnormal_respiratory_system	1.82390590
16	MP0005310_abnormal_salivary_gland	1.80734731
17	MP0008877_abnormal_DNA_methylation	1.77355338
18	MP0005451_abnormal_body_composition	1.70952701
19	MP0002210_abnormal_sex_determination	1.64765872
20	MP0000678_abnormal_parathyroid_gland	1.58447993
21	MP0005551_abnormal_eye_electrophysiolog	1.57003417
22	MP0003879_abnormal_hair_cell	1.54759885
23	MP0004742_abnormal_vestibular_system	1.53961499
24	MP0001968_abnormal_touch/_nociception	1.46455209
25	MP0002138_abnormal_hepatobiliary_system	1.39722544
26	MP0005253_abnormal_eye_physiology	1.39065234
27	MP0001145_abnormal_male_reproductive	1.36816252
28	MP0000653_abnormal_sex_gland	1.30601350
29	MP0002282_abnormal_trachea_morphology	1.22749978
30	MP0001984_abnormal_olfaction	1.20226612
31	MP0001963_abnormal_hearing_physiology	1.16721000
32	MP0002249_abnormal_larynx_morphology	1.15181540
33	MP0009115_abnormal_fat_cell	1.11316935
34	MP0005395_other_phenotype	1.05995490
35	MP0001765_abnormal_ion_homeostasis	1.05659375
36	MP0002735_abnormal_chemical_nociception	1.01946343
37	MP0002229_neurodegeneration	0.97351172
38	MP0009053_abnormal_anal_canal	0.97311696
39	MP0005423_abnormal_somatic_nervous	0.97102176
40	MP0009697_abnormal_copulation	0.93431055
41	MP0000026_abnormal_inner_ear	0.93304297
42	MP0001501_abnormal_sleep_pattern	0.91633395
43	MP0002127_abnormal_cardiovascular_syste	0.87885600
44	MP0002928_abnormal_bile_duct	0.87772543
45	MP0002067_abnormal_sensory_capabilities	0.86324685
46	MP0005167_abnormal_blood-brain_barrier	0.86306323
47	MP0002234_abnormal_pharynx_morphology	0.84902311
48	MP0008995_early_reproductive_senescence	0.84239061
49	MP0005367_renal/urinary_system_phenotyp	0.83173691
50	MP0000516_abnormal_urinary_system	0.83173691
51	MP0005248_abnormal_Harderian_gland	0.79004209
52	MP0010329_abnormal_lipoprotein_level	0.78006287
53	MP0009764_decreased_sensitivity_to	0.77117496
54	MP0004484_altered_response_of	0.75899763
55	MP0002733_abnormal_thermal_nociception	0.74880570
56	MP0000534_abnormal_ureter_morphology	0.73875634
57	MP0002557_abnormal_social/conspecific_i	0.73555436
58	MP0008961_abnormal_basal_metabolism	0.72480988
59	MP0009278_abnormal_bone_marrow	0.72170058
60	MP0000955_abnormal_spinal_cord	0.71368630
61	MP0002572_abnormal_emotion/affect_behav	0.70957754
62	MP0000569_abnormal_digit_pigmentation	0.69466465
63	MP0004085_abnormal_heartbeat	0.69345985
64	MP0002653_abnormal_ependyma_morphology	0.69119913
65	MP0009745_abnormal_behavioral_response	0.67785692
66	MP0000230_abnormal_systemic_arterial	0.65073700
67	MP0004510_myositis	0.64772485
68	MP0001545_abnormal_hematopoietic_system	0.64166196
69	MP0005397_hematopoietic_system_phenotyp	0.64166196
70	MP0005083_abnormal_biliary_tract	0.63592375
71	MP0004859_abnormal_synaptic_plasticity	0.62679073
72	MP0002254_reproductive_system_inflammat	0.61697077
73	MP0001270_distended_abdomen	0.59370164
74	MP0004233_abnormal_muscle_weight	0.56968109
75	MP0004084_abnormal_cardiac_muscle	0.56567731
76	MP0003787_abnormal_imprinting	0.56165761
77	MP0000003_abnormal_adipose_tissue	0.55813926
78	MP0005391_vision/eye_phenotype	0.55505636
79	MP0003045_fibrosis	0.54172658
80	MP0002272_abnormal_nervous_system	0.53859298
81	MP0002837_dystrophic_cardiac_calcinosis	0.52291474
82	MP0002168_other_aberrant_phenotype	0.51489234
83	MP0003136_yellow_coat_color	0.51442616
84	MP0000681_abnormal_thyroid_gland	0.51150662
85	MP0005332_abnormal_amino_acid	0.50468691
86	MP0003631_nervous_system_phenotype	0.50435282
87	MP0003195_calcinosis	0.49907751
88	MP0005084_abnormal_gallbladder_morpholo	0.49146215
89	MP0003633_abnormal_nervous_system	0.48564702
90	MP0004036_abnormal_muscle_relaxation	0.48550129
91	MP0000049_abnormal_middle_ear	0.47994206
92	MP0000470_abnormal_stomach_morphology	0.46956865
93	MP0005375_adipose_tissue_phenotype	0.46549118
94	MP0001986_abnormal_taste_sensitivity	0.46096879
95	MP0005636_abnormal_mineral_homeostasis	0.45930240
96	MP0008789_abnormal_olfactory_epithelium	0.45657685
97	MP0005645_abnormal_hypothalamus_physiol	0.45276118
98	MP0001970_abnormal_pain_threshold	0.44918893
99	MP0005535_abnormal_body_temperature	0.44125661
100	MP0001666_abnormal_nutrient_absorption	0.43497508

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	6.41274352
2	Chronic hepatic failure (HP:0100626)	6.32888209
3	Absent/shortened dynein arms (HP:0200106)	5.92441785
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.92441785
5	Tubulointerstitial nephritis (HP:0001970)	5.86378776
6	Attenuation of retinal blood vessels (HP:0007843)	4.89697258
7	Asymmetric septal hypertrophy (HP:0001670)	4.56033931
8	Bony spicule pigmentary retinopathy (HP:0007737)	4.47067643
9	Abnormal ciliary motility (HP:0012262)	4.33192330
10	Abnormal respiratory motile cilium physiology (HP:0012261)	4.22003485
11	Cone-rod dystrophy (HP:0000548)	4.21815229
12	Abnormality of macular pigmentation (HP:0008002)	4.12068973
13	Abnormal respiratory epithelium morphology (HP:0012253)	4.04651934
14	Abnormal respiratory motile cilium morphology (HP:0005938)	4.04651934
15	Hyperkalemia (HP:0002153)	3.99965645
16	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.87595828
17	Amelogenesis imperfecta (HP:0000705)	3.79705281
18	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.56278945
19	Nephronophthisis (HP:0000090)	3.56276878
20	Progressive cerebellar ataxia (HP:0002073)	3.53877385
21	Male infertility (HP:0003251)	3.38605014
22	Resting tremor (HP:0002322)	3.38583550
23	Hypoalphalipoproteinemia (HP:0003233)	3.37889359
24	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.34882202
25	Nasal polyposis (HP:0100582)	3.30265543
26	Infertility (HP:0000789)	3.29998548
27	Impulsivity (HP:0100710)	3.27677271
28	Abnormality of the renal medulla (HP:0100957)	3.23740254
29	Truncal obesity (HP:0001956)	3.18214413
30	Abnormal rod and cone electroretinograms (HP:0008323)	3.16383528
31	Hypoplasia of the thymus (HP:0000778)	3.15983263
32	Abnormality of dental color (HP:0011073)	3.11354250
33	Stage 5 chronic kidney disease (HP:0003774)	3.03205325
34	Tubulointerstitial abnormality (HP:0001969)	3.02980913
35	Facial shape deformation (HP:0011334)	3.00624032
36	Potter facies (HP:0002009)	3.00624032
37	Postural instability (HP:0002172)	2.96577612
38	Portal hypertension (HP:0001409)	2.88355628
39	Progressive sensorineural hearing impairment (HP:0000408)	2.82230994
40	Polydipsia (HP:0001959)	2.81860142
41	Abnormal drinking behavior (HP:0030082)	2.81860142
42	Hypoplastic ischia (HP:0003175)	2.81698085
43	Menstrual irregularities (HP:0000858)	2.79153597
44	Abnormal urine output (HP:0012590)	2.67763292
45	Abnormality of the hepatic vasculature (HP:0006707)	2.65434588
46	Bell-shaped thorax (HP:0001591)	2.64591493
47	Pancreatic cysts (HP:0001737)	2.64413513
48	Abnormality of the ischium (HP:0003174)	2.63998657
49	Tubular atrophy (HP:0000092)	2.62337453
50	Abnormality of the nasal mucosa (HP:0000433)	2.55842561
51	Enlarged epiphyses (HP:0010580)	2.54532197
52	Abnormal spermatogenesis (HP:0008669)	2.53205759
53	Polyuria (HP:0000103)	2.48676884
54	Abnormality of the aortic arch (HP:0012303)	2.47110302
55	Pancreatic fibrosis (HP:0100732)	2.46454522
56	Renovascular hypertension (HP:0100817)	2.43536173
57	Rhinitis (HP:0012384)	2.41332427
58	Insulin-resistant diabetes mellitus (HP:0000831)	2.38455939
59	Abnormal albumin level (HP:0012116)	2.37091804
60	Hypoalbuminemia (HP:0003073)	2.37091804
61	Abnormality of potassium homeostasis (HP:0011042)	2.35551174
62	Abnormality of the renal cortex (HP:0011035)	2.34913391
63	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.34464793
64	Intellectual disability, moderate (HP:0002342)	2.27901111
65	Abnormality of renal excretion (HP:0011036)	2.24600494
66	Azoospermia (HP:0000027)	2.21712472
67	Type II lissencephaly (HP:0007260)	2.16419887
68	Optic nerve hypoplasia (HP:0000609)	2.15800794
69	Pendular nystagmus (HP:0012043)	2.13208870
70	Genetic anticipation (HP:0003743)	2.10488563
71	Decreased central vision (HP:0007663)	2.09999600
72	Cerebellar dysplasia (HP:0007033)	2.06282929
73	Chronic bronchitis (HP:0004469)	2.05411740
74	Photophobia (HP:0000613)	2.00264607
75	Focal segmental glomerulosclerosis (HP:0000097)	1.99700416
76	True hermaphroditism (HP:0010459)	1.96169911
77	Bronchiectasis (HP:0002110)	1.95844399
78	Generalized aminoaciduria (HP:0002909)	1.93761439
79	Occipital encephalocele (HP:0002085)	1.91867863
80	Renal dysplasia (HP:0000110)	1.90918818
81	Congenital sensorineural hearing impairment (HP:0008527)	1.88474035
82	Cystic liver disease (HP:0006706)	1.86477946
83	Abnormality of the costochondral junction (HP:0000919)	1.86464347
84	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.86044661
85	Hyperuricemia (HP:0002149)	1.82428277
86	Increased purine levels (HP:0004368)	1.82428277
87	Osteomalacia (HP:0002749)	1.81811196
88	Abnormality of midbrain morphology (HP:0002418)	1.80898068
89	Molar tooth sign on MRI (HP:0002419)	1.80898068
90	Thyroid-stimulating hormone excess (HP:0002925)	1.80427362
91	Hypophosphatemic rickets (HP:0004912)	1.78425783
92	Sandal gap (HP:0001852)	1.77604559
93	Type II diabetes mellitus (HP:0005978)	1.71118289
94	Congenital hepatic fibrosis (HP:0002612)	1.69493493
95	Glomerulosclerosis (HP:0000096)	1.68586335
96	Volvulus (HP:0002580)	1.67415070
97	Keratoconus (HP:0000563)	1.63985450
98	Increased corneal curvature (HP:0100692)	1.63985450
99	Subcapsular cataract (HP:0000523)	1.63945847
100	Hypolipoproteinemia (HP:0010981)	1.61289523

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.68632694
2	INSRR	4.87333621
3	BRD4	4.16932474
4	PLK2	3.37475410
5	PNCK	2.91083830
6	MAP4K2	2.90072265
7	FRK	2.63456894
8	TESK1	2.51958497
9	CAMK1G	2.50701041
10	STK38L	2.50421522
11	STK38	2.45965308
12	DDR2	2.39888330
13	PIK3CG	2.28968606
14	CDK12	1.80493901
15	PRKD3	1.72248428
16	MAPK15	1.63279884
17	PINK1	1.53293917
18	BMPR1B	1.52834868
19	AKT3	1.46379654
20	ADRBK2	1.43289617
21	PTK2B	1.38934250
22	PDK1	1.35180580
23	TYRO3	1.34318503
24	ACVR1B	1.33541472
25	WNK1	1.31408689
26	PDPK1	1.25638940
27	CAMK1D	1.21375666
28	TAOK3	1.21193109
29	LATS1	1.14808472
30	NEK6	1.14435525
31	ZAK	0.91455762
32	DYRK1B	0.82746368
33	SIK2	0.79609391
34	PRKAA2	0.78259677
35	TIE1	0.75840291
36	CDK7	0.75137859
37	MAP2K2	0.73126709
38	MAP3K4	0.68145788
39	BLK	0.67691578
40	CDK3	0.66171414
41	MST1R	0.58051429
42	WNK4	0.57712495
43	PRKG1	0.55329607
44	STK39	0.53258430
45	TLK1	0.53111641
46	CAMK1	0.51492493
47	TNIK	0.51059054
48	SGK2	0.50932757
49	SGK494	0.50797597
50	SGK223	0.50797597
51	WNK3	0.50312282
52	CAMK4	0.48783005
53	BRSK2	0.48119017
54	MAP2K7	0.46436510
55	NTRK3	0.45716026
56	OXSR1	0.45554552
57	MARK1	0.45347741
58	MAPK1	0.44391318
59	PRKG2	0.43789852
60	DYRK3	0.43093604
61	GRK1	0.41687739
62	PRKCG	0.41494129
63	MAP3K7	0.40521720
64	GSK3B	0.38286607
65	NEK2	0.38006245
66	NLK	0.36837592
67	RPS6KA1	0.35675320
68	MAPK11	0.35663422
69	RPS6KA2	0.35482937
70	NUAK1	0.34191002
71	MUSK	0.34124690
72	CDK1	0.33775982
73	CDK2	0.31653744
74	MAPK13	0.30912059
75	SGK1	0.29442917
76	PRKAA1	0.27939113
77	NTRK2	0.27651504
78	KSR2	0.27379170
79	CHUK	0.27253615
80	TGFBR1	0.26635803
81	MAPK8	0.25931750
82	MAP3K11	0.25014435
83	RPS6KA6	0.24793378
84	PRKCZ	0.24722083
85	OBSCN	0.24563172
86	VRK1	0.23447744
87	TNK2	0.23313544
88	BRAF	0.22642860
89	LATS2	0.21496967
90	GRK6	0.21160015
91	PRKCB	0.21120221
92	FGFR2	0.21116057
93	PRKCE	0.21056143
94	MAPK14	0.20607068
95	MTOR	0.20194633
96	MARK3	0.19801974
97	JAK3	0.19178211
98	RIPK1	0.17976233
99	IKBKB	0.17787043
100	AKT1	0.17156910

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	5.77649096
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.52414348
3	Olfactory transduction_Homo sapiens_hsa04740	4.08436727
4	Butanoate metabolism_Homo sapiens_hsa00650	2.87680365
5	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.29302593
6	Taste transduction_Homo sapiens_hsa04742	2.25188435
7	Phototransduction_Homo sapiens_hsa04744	2.08592208
8	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.88699527
9	ABC transporters_Homo sapiens_hsa02010	1.78058222
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.64130463
11	RNA transport_Homo sapiens_hsa03013	1.62642456
12	Fatty acid degradation_Homo sapiens_hsa00071	1.57440738
13	Type II diabetes mellitus_Homo sapiens_hsa04930	1.41257140
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.37835159
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.35783382
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.32572297
17	Fatty acid metabolism_Homo sapiens_hsa01212	1.28344779
18	Morphine addiction_Homo sapiens_hsa05032	1.27994732
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.24154071
20	Nicotine addiction_Homo sapiens_hsa05033	1.23175575
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.14468934
22	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.13186728
23	Phenylalanine metabolism_Homo sapiens_hsa00360	1.13088311
24	Salivary secretion_Homo sapiens_hsa04970	1.08868944
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.07858638
26	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.07071292
27	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.03786086
28	Calcium signaling pathway_Homo sapiens_hsa04020	1.03765378
29	Linoleic acid metabolism_Homo sapiens_hsa00591	0.97400272
30	Glycerolipid metabolism_Homo sapiens_hsa00561	0.95275995
31	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.94124582
32	Retinol metabolism_Homo sapiens_hsa00830	0.93153330
33	Selenocompound metabolism_Homo sapiens_hsa00450	0.91905266
34	cAMP signaling pathway_Homo sapiens_hsa04024	0.91467126
35	Allograft rejection_Homo sapiens_hsa05330	0.88901913
36	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.88574718
37	Graft-versus-host disease_Homo sapiens_hsa05332	0.87803044
38	Glutamatergic synapse_Homo sapiens_hsa04724	0.87552265
39	Circadian entrainment_Homo sapiens_hsa04713	0.87397905
40	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.86817898
41	Basal transcription factors_Homo sapiens_hsa03022	0.86008992
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82972178
43	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.82713011
44	Serotonergic synapse_Homo sapiens_hsa04726	0.81403913
45	PPAR signaling pathway_Homo sapiens_hsa03320	0.80821045
46	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.77949294
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75886691
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.75878067
49	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.74251534
50	Antigen processing and presentation_Homo sapiens_hsa04612	0.73361522
51	Insulin secretion_Homo sapiens_hsa04911	0.72105745
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.71271193
53	Renin secretion_Homo sapiens_hsa04924	0.69996277
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.69260225
55	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.67399177
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67170638
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.67018209
58	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.63083319
59	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.62752978
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.62567951
61	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.62293198
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62197247
63	Lysine degradation_Homo sapiens_hsa00310	0.59932133
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.59466680
65	Arginine biosynthesis_Homo sapiens_hsa00220	0.58140669
66	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.58115393
67	Influenza A_Homo sapiens_hsa05164	0.57993521
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.56559289
69	Estrogen signaling pathway_Homo sapiens_hsa04915	0.55905135
70	Circadian rhythm_Homo sapiens_hsa04710	0.54485349
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.51761322
72	GABAergic synapse_Homo sapiens_hsa04727	0.51337469
73	Caffeine metabolism_Homo sapiens_hsa00232	0.48971955
74	Regulation of autophagy_Homo sapiens_hsa04140	0.48868646
75	Gastric acid secretion_Homo sapiens_hsa04971	0.47614340
76	Oocyte meiosis_Homo sapiens_hsa04114	0.47592758
77	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.46860049
78	Bile secretion_Homo sapiens_hsa04976	0.46705031
79	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.45314731
80	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.45003037
81	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.43924458
82	MAPK signaling pathway_Homo sapiens_hsa04010	0.43561029
83	Endocytosis_Homo sapiens_hsa04144	0.43431738
84	Pancreatic secretion_Homo sapiens_hsa04972	0.43179782
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.42779360
86	Protein digestion and absorption_Homo sapiens_hsa04974	0.41358002
87	Viral myocarditis_Homo sapiens_hsa05416	0.40659408
88	Propanoate metabolism_Homo sapiens_hsa00640	0.40061031
89	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.39604123
90	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.38281322
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38281083
92	Cardiac muscle contraction_Homo sapiens_hsa04260	0.38174407
93	Cholinergic synapse_Homo sapiens_hsa04725	0.36450755
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.36447646
95	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.34999841
96	Purine metabolism_Homo sapiens_hsa00230	0.34206879
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33633081
98	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.31943506
99	Amphetamine addiction_Homo sapiens_hsa05031	0.28744935
100	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.28048049

GTF2IP12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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