ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	7.24072394
2	response to pheromone (GO:0019236)	7.22714074
3	acrosome reaction (GO:0007340)	7.07712957
4	protein polyglutamylation (GO:0018095)	6.34726682
5	fusion of sperm to egg plasma membrane (GO:0007342)	5.72844049
6	behavioral response to nicotine (GO:0035095)	5.49698415
7	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.17542584
8	phosphatidylethanolamine metabolic process (GO:0046337)	4.84839635
9	multicellular organism reproduction (GO:0032504)	4.80776641
10	calcium ion-dependent exocytosis (GO:0017156)	4.69143510
11	spermatid development (GO:0007286)	4.67246201
12	sperm capacitation (GO:0048240)	4.55626410
13	single strand break repair (GO:0000012)	4.41505707
14	plasma membrane fusion (GO:0045026)	4.36790920
15	cilium or flagellum-dependent cell motility (GO:0001539)	4.28623960
16	axonemal dynein complex assembly (GO:0070286)	4.26618668
17	sperm-egg recognition (GO:0035036)	4.20497574
18	establishment of protein localization to Golgi (GO:0072600)	4.13406639
19	DNA packaging (GO:0006323)	4.11982124
20	chromosome condensation (GO:0030261)	4.03843397
21	reproduction (GO:0000003)	3.99410612
22	protein localization to Golgi apparatus (GO:0034067)	3.98843129
23	negative regulation of Rho protein signal transduction (GO:0035024)	3.94381426
24	tooth mineralization (GO:0034505)	3.94285457
25	protein targeting to Golgi (GO:0000042)	3.92092037
26	motile cilium assembly (GO:0044458)	3.89335752
27	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.87153264
28	epithelial cilium movement (GO:0003351)	3.86877552
29	RNA destabilization (GO:0050779)	3.81467136
30	microtubule depolymerization (GO:0007019)	3.77180559
31	spermatogenesis (GO:0007283)	3.74476772
32	male gamete generation (GO:0048232)	3.74245558
33	DNA methylation involved in gamete generation (GO:0043046)	3.73516703
34	regulation of cilium movement (GO:0003352)	3.72993280
35	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.69829640
36	centriole replication (GO:0007099)	3.66753634
37	primary amino compound metabolic process (GO:1901160)	3.62160072
38	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.59439674
39	piRNA metabolic process (GO:0034587)	3.55855151
40	axoneme assembly (GO:0035082)	3.55226093
41	somite development (GO:0061053)	3.53941586
42	cellular ketone body metabolic process (GO:0046950)	3.51880222
43	cilium movement (GO:0003341)	3.49983229
44	gamete generation (GO:0007276)	3.46095597
45	cell-cell recognition (GO:0009988)	3.43651754
46	chaperone-mediated protein complex assembly (GO:0051131)	3.42394813
47	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.42004008
48	positive regulation of glomerulus development (GO:0090193)	3.32749823
49	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.32483831
50	cell proliferation in forebrain (GO:0021846)	3.30487938
51	binding of sperm to zona pellucida (GO:0007339)	3.29195323
52	positive regulation of Rab GTPase activity (GO:0032851)	3.27704950
53	regulation of Rab GTPase activity (GO:0032313)	3.27704950
54	male meiosis I (GO:0007141)	3.27164454
55	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.25047155
56	appendage development (GO:0048736)	3.21042243
57	limb development (GO:0060173)	3.21042243
58	rRNA methylation (GO:0031167)	3.17673774
59	musculoskeletal movement (GO:0050881)	3.17267290
60	multicellular organismal movement (GO:0050879)	3.17267290
61	centriole assembly (GO:0098534)	3.14766590
62	microtubule polymerization or depolymerization (GO:0031109)	3.13791430
63	spinal cord motor neuron differentiation (GO:0021522)	3.10747993
64	water-soluble vitamin biosynthetic process (GO:0042364)	3.09633481
65	positive regulation of action potential (GO:0045760)	3.08224681
66	DNA deamination (GO:0045006)	3.07092578
67	male meiosis (GO:0007140)	3.03574315
68	spermatid nucleus differentiation (GO:0007289)	3.03187163
69	lung secretory cell differentiation (GO:0061140)	3.03075923
70	regulation of mesoderm development (GO:2000380)	3.02066318
71	ketone body metabolic process (GO:1902224)	3.01944796
72	seminiferous tubule development (GO:0072520)	3.01933300
73	regulation of glomerulus development (GO:0090192)	3.01593701
74	single fertilization (GO:0007338)	3.00783782
75	pharyngeal system development (GO:0060037)	2.99861537
76	serotonin metabolic process (GO:0042428)	2.99236512
77	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.98473330
78	chromatin silencing (GO:0006342)	2.97932277
79	microtubule severing (GO:0051013)	2.94401687
80	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.88784144
81	synaptonemal complex assembly (GO:0007130)	2.87902333
82	endoderm formation (GO:0001706)	2.87866888
83	indolalkylamine metabolic process (GO:0006586)	2.81452127
84	gamma-aminobutyric acid transport (GO:0015812)	2.79215922
85	cellular response to pH (GO:0071467)	2.77768170
86	cellular response to ATP (GO:0071318)	2.76948197
87	lung morphogenesis (GO:0060425)	2.75191967
88	phosphorelay signal transduction system (GO:0000160)	2.74784086
89	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.73996851
90	negative regulation of astrocyte differentiation (GO:0048712)	2.72068662
91	germ cell development (GO:0007281)	2.71958017
92	multicellular organismal reproductive process (GO:0048609)	2.71357289
93	membrane depolarization during action potential (GO:0086010)	2.68223987
94	rRNA modification (GO:0000154)	2.67461109
95	negative regulation of T cell differentiation in thymus (GO:0033085)	2.67449193
96	organic cation transport (GO:0015695)	2.67360560
97	cellular response to exogenous dsRNA (GO:0071360)	2.65875829
98	synaptonemal complex organization (GO:0070193)	2.64923242
99	membrane repolarization during action potential (GO:0086011)	2.64112811
100	regulation of action potential (GO:0098900)	2.63849790

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.21509507
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.94028872
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.26922250
4	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.54901797
5	DROSHA_22980978_ChIP-Seq_HELA_Human	2.16926525
6	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.11272709
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.00086788
8	ZNF274_21170338_ChIP-Seq_K562_Hela	1.87011941
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.81812973
10	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.80561018
11	BCL6_27268052_Chip-Seq_Bcells_Human	1.79727151
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.78991199
13	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.78991199
14	ERA_21632823_ChIP-Seq_H3396_Human	1.76522535
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.75809930
16	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.75420179
17	P68_20966046_ChIP-Seq_HELA_Human	1.67938802
18	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.66550568
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65219304
20	E2F1_20622854_ChIP-Seq_HELA_Human	1.63691200
21	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.62572850
22	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.62327241
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.61559209
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.61459964
25	TAF2_19829295_ChIP-Seq_ESCs_Human	1.60252198
26	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.58256708
27	RAC3_21632823_ChIP-Seq_H3396_Human	1.54370597
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.53699872
29	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.53013944
30	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.52230850
31	VDR_22108803_ChIP-Seq_LS180_Human	1.51603053
32	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.51599351
33	NANOG_20526341_ChIP-Seq_ESCs_Human	1.49721187
34	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48987352
35	PHF8_20622854_ChIP-Seq_HELA_Human	1.45162033
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.44891158
37	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.44228226
38	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.43696721
39	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.42207512
40	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.41933918
41	MYC_19829295_ChIP-Seq_ESCs_Human	1.40966196
42	CTCF_20526341_ChIP-Seq_ESCs_Human	1.40367722
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39896459
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.39896459
45	RUNX_20019798_ChIP-Seq_JUKART_Human	1.35550731
46	OCT4_20526341_ChIP-Seq_ESCs_Human	1.35420468
47	BCOR_27268052_Chip-Seq_Bcells_Human	1.35080317
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.34247067
49	REST_21632747_ChIP-Seq_MESCs_Mouse	1.33935877
50	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.33620189
51	CTCF_27219007_Chip-Seq_Bcells_Human	1.33374927
52	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.32524123
53	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.31604743
54	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.31009679
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29257928
56	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.29036812
57	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.28115875
58	P300_27268052_Chip-Seq_Bcells_Human	1.27793867
59	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26804442
60	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25315305
61	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.24671806
62	AR_21572438_ChIP-Seq_LNCaP_Human	1.23228591
63	SMRT_27268052_Chip-Seq_Bcells_Human	1.21283587
64	FUS_26573619_Chip-Seq_HEK293_Human	1.20334070
65	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.16190861
66	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.12910762
67	SMC4_20622854_ChIP-Seq_HELA_Human	1.12472521
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12267639
69	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.11740032
70	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.11688775
71	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11532644
72	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.10892892
73	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10701974
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10701974
75	GBX2_23144817_ChIP-Seq_PC3_Human	1.10580030
76	OCT4_19829295_ChIP-Seq_ESCs_Human	1.10114284
77	NCOR_22424771_ChIP-Seq_293T_Human	1.09191147
78	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.08640005
79	P53_21459846_ChIP-Seq_SAOS-2_Human	1.08193981
80	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.06552774
81	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.05057627
82	STAT3_23295773_ChIP-Seq_U87_Human	1.04982307
83	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04066367
84	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02300922
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00815209
86	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.00430920
87	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.00329854
88	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.99921146
89	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.99818540
90	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.99818540
91	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.99719703
92	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.98864394
93	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.98638232
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.98414876
95	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.98326765
96	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.97889978
97	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.97732439
98	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.97627056
99	TP63_22573176_ChIP-Seq_HFKS_Human	0.97213645
100	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97090767

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	7.35388523
2	MP0005410_abnormal_fertilization	5.65650034
3	MP0002837_dystrophic_cardiac_calcinosis	5.29271980
4	MP0005377_hearing/vestibular/ear_phenot	2.97832293
5	MP0003878_abnormal_ear_physiology	2.97832293
6	MP0005670_abnormal_white_adipose	2.61401889
7	MP0006292_abnormal_olfactory_placode	2.57378925
8	MP0000678_abnormal_parathyroid_gland	2.51349984
9	MP0001348_abnormal_lacrimal_gland	2.34569424
10	MP0005646_abnormal_pituitary_gland	2.21866451
11	MP0003698_abnormal_male_reproductive	2.21828283
12	MP0009053_abnormal_anal_canal	2.18061311
13	MP0004130_abnormal_muscle_cell	2.07911973
14	MP0002138_abnormal_hepatobiliary_system	1.92855940
15	MP0001929_abnormal_gametogenesis	1.90639500
16	MP0002653_abnormal_ependyma_morphology	1.88051516
17	MP0001968_abnormal_touch/_nociception	1.84476632
18	MP0003011_delayed_dark_adaptation	1.83768611
19	MP0003879_abnormal_hair_cell	1.83310534
20	MP0001485_abnormal_pinna_reflex	1.78449395
21	MP0002160_abnormal_reproductive_system	1.76096046
22	MP0002249_abnormal_larynx_morphology	1.73407470
23	MP0000049_abnormal_middle_ear	1.66407843
24	MP0004185_abnormal_adipocyte_glucose	1.63414004
25	MP0008775_abnormal_heart_ventricle	1.60401202
26	MP0001853_heart_inflammation	1.58306073
27	MP0008877_abnormal_DNA_methylation	1.51470612
28	MP0008789_abnormal_olfactory_epithelium	1.39409674
29	MP0005389_reproductive_system_phenotype	1.38694095
30	MP0005671_abnormal_response_to	1.38245034
31	MP0005379_endocrine/exocrine_gland_phen	1.36860799
32	MP0002282_abnormal_trachea_morphology	1.26828345
33	MP0005551_abnormal_eye_electrophysiolog	1.24359937
34	MP0000026_abnormal_inner_ear	1.20501833
35	MP0003119_abnormal_digestive_system	1.18769597
36	MP0004885_abnormal_endolymph	1.17041173
37	MP0002210_abnormal_sex_determination	1.15091159
38	MP0000631_abnormal_neuroendocrine_gland	1.13857051
39	MP0002736_abnormal_nociception_after	1.11657857
40	MP0004145_abnormal_muscle_electrophysio	1.10857931
41	MP0001486_abnormal_startle_reflex	1.10304815
42	MP0001963_abnormal_hearing_physiology	1.09940856
43	MP0002102_abnormal_ear_morphology	1.09478036
44	MP0002928_abnormal_bile_duct	1.09027357
45	MP0002161_abnormal_fertility/fecundity	1.08469259
46	MP0008995_early_reproductive_senescence	1.08208755
47	MP0001666_abnormal_nutrient_absorption	1.04218315
48	MP0001765_abnormal_ion_homeostasis	1.03940343
49	MP0003938_abnormal_ear_development	1.00085862
50	MP0002234_abnormal_pharynx_morphology	0.96990429
51	MP0004742_abnormal_vestibular_system	0.95415192
52	MP0001145_abnormal_male_reproductive	0.95227204
53	MP0002735_abnormal_chemical_nociception	0.95212485
54	MP0002733_abnormal_thermal_nociception	0.91848757
55	MP0000653_abnormal_sex_gland	0.91527077
56	MP0002272_abnormal_nervous_system	0.91346290
57	MP0005394_taste/olfaction_phenotype	0.90487902
58	MP0005499_abnormal_olfactory_system	0.90487902
59	MP0009250_abnormal_appendicular_skeleto	0.88350953
60	MP0008872_abnormal_physiological_respon	0.88045423
61	MP0005666_abnormal_adipose_tissue	0.86529795
62	MP0004133_heterotaxia	0.85805910
63	MP0000537_abnormal_urethra_morphology	0.85775227
64	MP0004142_abnormal_muscle_tone	0.85312836
65	MP0002932_abnormal_joint_morphology	0.84607901
66	MP0002229_neurodegeneration	0.82766545
67	MP0001919_abnormal_reproductive_system	0.82417197
68	MP0002876_abnormal_thyroid_physiology	0.81772814
69	MP0009745_abnormal_behavioral_response	0.81724323
70	MP0000685_abnormal_immune_system	0.79181511
71	MP0005360_urolithiasis	0.74286371
72	MP0002132_abnormal_respiratory_system	0.74118616
73	MP0005310_abnormal_salivary_gland	0.73721751
74	MP0009115_abnormal_fat_cell	0.73493607
75	MP0005253_abnormal_eye_physiology	0.73004459
76	MP0006072_abnormal_retinal_apoptosis	0.72511628
77	MP0001970_abnormal_pain_threshold	0.71794302
78	MP0000230_abnormal_systemic_arterial	0.71636633
79	MP0002557_abnormal_social/conspecific_i	0.70559569
80	MP0003718_maternal_effect	0.70203703
81	MP0002572_abnormal_emotion/affect_behav	0.68522996
82	MP0003942_abnormal_urinary_system	0.66880018
83	MP0003195_calcinosis	0.66184240
84	MP0003567_abnormal_fetal_cardiomyocyte	0.66163263
85	MP0000681_abnormal_thyroid_gland	0.65502945
86	MP0002067_abnormal_sensory_capabilities	0.64747117
87	MP0000955_abnormal_spinal_cord	0.62562194
88	MP0003136_yellow_coat_color	0.62456897
89	MP0005423_abnormal_somatic_nervous	0.61736554
90	MP0004085_abnormal_heartbeat	0.59675129
91	MP0003937_abnormal_limbs/digits/tail_de	0.58877648
92	MP0005647_abnormal_sex_gland	0.57969546
93	MP0003936_abnormal_reproductive_system	0.57364375
94	MP0000470_abnormal_stomach_morphology	0.55674695
95	MP0003635_abnormal_synaptic_transmissio	0.55609326
96	MP0002752_abnormal_somatic_nervous	0.54752347
97	MP0001986_abnormal_taste_sensitivity	0.53899272
98	MP0003638_abnormal_response/metabolism_	0.53712751
99	MP0002822_catalepsy	0.53511895
100	MP0009764_decreased_sensitivity_to	0.52356129

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	4.88532508
2	Absent/shortened dynein arms (HP:0200106)	4.26942426
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.26942426
4	Nephronophthisis (HP:0000090)	4.16224766
5	Abnormality of the proximal phalanges of the hand (HP:0009834)	3.62358535
6	Attenuation of retinal blood vessels (HP:0007843)	3.60367508
7	Abnormal rod and cone electroretinograms (HP:0008323)	3.55275110
8	Abnormal ciliary motility (HP:0012262)	3.54146017
9	Abnormality of the renal medulla (HP:0100957)	3.52468096
10	Chronic hepatic failure (HP:0100626)	3.49858340
11	Bony spicule pigmentary retinopathy (HP:0007737)	3.49696957
12	Pancreatic cysts (HP:0001737)	3.46474726
13	Abnormality of the nasal septum (HP:0000419)	3.44664418
14	Genetic anticipation (HP:0003743)	3.40788707
15	Abnormal respiratory motile cilium morphology (HP:0005938)	3.35440073
16	Abnormal respiratory epithelium morphology (HP:0012253)	3.35440073
17	Congenital stationary night blindness (HP:0007642)	3.29196734
18	Abnormal respiratory motile cilium physiology (HP:0012261)	3.19003767
19	Pendular nystagmus (HP:0012043)	3.15956508
20	Progressive cerebellar ataxia (HP:0002073)	3.11046290
21	True hermaphroditism (HP:0010459)	2.88772379
22	Pancreatic fibrosis (HP:0100732)	2.88120755
23	Abnormality of the middle phalanges of the toes (HP:0010183)	2.77521686
24	Fibular aplasia (HP:0002990)	2.72443851
25	Molar tooth sign on MRI (HP:0002419)	2.70780299
26	Abnormality of midbrain morphology (HP:0002418)	2.70780299
27	Abnormality of DNA repair (HP:0003254)	2.70353547
28	Morphological abnormality of the middle ear (HP:0008609)	2.64487472
29	Abnormality of the costochondral junction (HP:0000919)	2.62701549
30	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.60811937
31	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.59980844
32	Short 1st metacarpal (HP:0010034)	2.59980844
33	Synostosis of carpal bones (HP:0005048)	2.59183304
34	Short femoral neck (HP:0100864)	2.57073305
35	Tubular atrophy (HP:0000092)	2.55377217
36	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.50601138
37	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.47428822
38	Polydipsia (HP:0001959)	2.47288726
39	Abnormal drinking behavior (HP:0030082)	2.47288726
40	Cystic liver disease (HP:0006706)	2.46244157
41	Decreased central vision (HP:0007663)	2.42903333
42	Osteomalacia (HP:0002749)	2.41292587
43	Abnormality of the renal cortex (HP:0011035)	2.40078832
44	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.30312944
45	Decreased circulating renin level (HP:0003351)	2.28019051
46	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.26023429
47	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	2.25922407
48	Abnormality of the 1st metacarpal (HP:0010009)	2.23410897
49	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.17282799
50	Hypoplasia of the uterus (HP:0000013)	2.16525824
51	Short phalanx of the thumb (HP:0009660)	2.15631393
52	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.15179628
53	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.15010203
54	Short 4th metacarpal (HP:0010044)	2.15010203
55	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.14200356
56	Asplenia (HP:0001746)	2.13867683
57	Abnormality of the renal collecting system (HP:0004742)	2.13255589
58	Potter facies (HP:0002009)	2.12768673
59	Facial shape deformation (HP:0011334)	2.12768673
60	Abolished electroretinogram (ERG) (HP:0000550)	2.10390545
61	Stage 5 chronic kidney disease (HP:0003774)	2.08756514
62	Renal dysplasia (HP:0000110)	2.08237268
63	Hyperkalemia (HP:0002153)	2.08064658
64	Polyuria (HP:0000103)	2.08026134
65	Chorioretinal atrophy (HP:0000533)	2.06966222
66	Type II lissencephaly (HP:0007260)	2.04659378
67	Increased corneal curvature (HP:0100692)	2.03649182
68	Keratoconus (HP:0000563)	2.03649182
69	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.01997959
70	Hypoplastic ischia (HP:0003175)	2.00912348
71	Abnormality of the 4th metacarpal (HP:0010012)	2.00543568
72	Abnormal urine output (HP:0012590)	2.00136964
73	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.97732155
74	Tubulointerstitial nephritis (HP:0001970)	1.96942528
75	Infertility (HP:0000789)	1.96536519
76	Methylmalonic acidemia (HP:0002912)	1.96499004
77	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.95004428
78	Abnormality of the aortic arch (HP:0012303)	1.94429003
79	Anencephaly (HP:0002323)	1.93995757
80	Abnormality of renal excretion (HP:0011036)	1.93546349
81	IgG deficiency (HP:0004315)	1.92921412
82	Sclerocornea (HP:0000647)	1.91852730
83	Congenital hepatic fibrosis (HP:0002612)	1.91590155
84	Methylmalonic aciduria (HP:0012120)	1.90586125
85	Aplasia/hypoplasia of the uterus (HP:0008684)	1.90492544
86	Congenital sensorineural hearing impairment (HP:0008527)	1.89642892
87	Rhinitis (HP:0012384)	1.87985258
88	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.87197942
89	Abnormality of the columella (HP:0009929)	1.85960450
90	Absent phalangeal crease (HP:0006109)	1.84696618
91	Hyperglycinemia (HP:0002154)	1.83579941
92	Impulsivity (HP:0100710)	1.83120579
93	Enlarged kidneys (HP:0000105)	1.82040099
94	Stereotypic behavior (HP:0000733)	1.80289418
95	Absent thumb (HP:0009777)	1.79187383
96	Carpal synostosis (HP:0009702)	1.77860056
97	Confusion (HP:0001289)	1.75401752
98	Abnormality of the neuromuscular junction (HP:0003398)	1.73686592
99	Fatigable weakness (HP:0003473)	1.73686592
100	Enlarged epiphyses (HP:0010580)	1.72697660

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.60754220
2	PLK4	4.14820770
3	TLK1	3.42510813
4	INSRR	3.16313266
5	MAP3K9	2.77145298
6	MAP4K2	2.62003469
7	WNK4	2.38803443
8	TXK	2.25382478
9	GRK1	2.13144177
10	TAOK3	2.12893352
11	PINK1	2.06879969
12	RIPK4	1.94019856
13	STK38	1.88919752
14	PLK2	1.80769996
15	ADRBK2	1.78742519
16	MAPK15	1.74917352
17	TNK2	1.63676112
18	MAP2K2	1.62091342
19	TESK1	1.60252559
20	DDR2	1.59037339
21	SIK2	1.49712013
22	PRKD2	1.46077872
23	GRK6	1.27993500
24	CAMK1G	1.27921648
25	MAP4K1	1.23173499
26	IKBKB	1.18914589
27	RPS6KA2	1.17473937
28	PTK2B	1.16741388
29	BMPR1B	1.12578061
30	RPS6KA6	1.05771157
31	ZAK	1.01817055
32	PIK3CG	1.01760169
33	SGK494	1.01347224
34	SGK223	1.01347224
35	STK39	0.99627461
36	STK38L	0.97542030
37	PDPK1	0.96602951
38	PNCK	0.95932600
39	MAPKAPK3	0.95689828
40	WNK1	0.93392725
41	PDK1	0.90143893
42	PRKD3	0.88079167
43	SGK2	0.86455056
44	SGK1	0.84452538
45	NTRK3	0.83910251
46	FGFR2	0.83776906
47	BCKDK	0.82353605
48	BLK	0.80957028
49	RPS6KC1	0.79729546
50	RPS6KL1	0.79729546
51	MAPK13	0.79513499
52	TESK2	0.79171873
53	MAP2K6	0.74952622
54	PHKG2	0.74068030
55	PHKG1	0.74068030
56	CAMK1D	0.72310967
57	DYRK2	0.70722081
58	MAP3K11	0.70688100
59	TYRO3	0.69735785
60	BRD4	0.68013626
61	PRKCZ	0.67852638
62	CAMK1	0.66885633
63	RPS6KA1	0.66088723
64	MUSK	0.63460064
65	ACVR1B	0.62989513
66	PRKCQ	0.62065651
67	CHUK	0.61552442
68	ITK	0.60520935
69	MAP3K4	0.59931509
70	KIT	0.59549230
71	NUAK1	0.58715144
72	WNK3	0.58364393
73	CSK	0.57085271
74	PRKAA1	0.56704548
75	MAP3K7	0.55971573
76	NME1	0.55839494
77	BTK	0.55484400
78	OXSR1	0.53937120
79	DYRK1B	0.53111680
80	CDK7	0.52432183
81	IKBKE	0.52200304
82	TIE1	0.51887180
83	STK16	0.51731355
84	PRKAA2	0.50559959
85	NTRK2	0.48663186
86	SYK	0.48397546
87	MARK2	0.46269747
88	DAPK2	0.46082048
89	LYN	0.45704703
90	ADRBK1	0.45598476
91	SGK3	0.45310878
92	PRKCG	0.45133765
93	ERBB2	0.44844628
94	PRKACA	0.44619429
95	AURKA	0.44382866
96	STK11	0.44196347
97	HCK	0.43759296
98	LCK	0.42236284
99	KDR	0.41985289
100	MAPK8	0.41256896

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.76347682
2	Olfactory transduction_Homo sapiens_hsa04740	2.73472501
3	Phototransduction_Homo sapiens_hsa04744	2.69001443
4	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.60053773
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.57929533
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.55893426
7	Type II diabetes mellitus_Homo sapiens_hsa04930	2.42220766
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.10078599
9	Nicotine addiction_Homo sapiens_hsa05033	2.09796141
10	Taste transduction_Homo sapiens_hsa04742	1.83102849
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.78723299
12	Glycerolipid metabolism_Homo sapiens_hsa00561	1.77004316
13	Graft-versus-host disease_Homo sapiens_hsa05332	1.74311549
14	Antigen processing and presentation_Homo sapiens_hsa04612	1.72221907
15	Morphine addiction_Homo sapiens_hsa05032	1.65982900
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.65833139
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.64153705
18	Sulfur relay system_Homo sapiens_hsa04122	1.62358707
19	Butanoate metabolism_Homo sapiens_hsa00650	1.54530518
20	Retinol metabolism_Homo sapiens_hsa00830	1.53109451
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.51607612
22	Allograft rejection_Homo sapiens_hsa05330	1.51169265
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49056663
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.47714878
25	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.47492871
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.46756977
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.41518982
28	Fat digestion and absorption_Homo sapiens_hsa04975	1.32039789
29	Type I diabetes mellitus_Homo sapiens_hsa04940	1.30551589
30	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.25084949
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.24744940
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20721790
33	Homologous recombination_Homo sapiens_hsa03440	1.18725345
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.17490557
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.16223657
36	Circadian entrainment_Homo sapiens_hsa04713	1.15099121
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.13815965
38	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.11369303
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.10600877
40	Calcium signaling pathway_Homo sapiens_hsa04020	1.09300895
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.07463517
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.06095332
43	RNA polymerase_Homo sapiens_hsa03020	1.05122572
44	Insulin resistance_Homo sapiens_hsa04931	1.04514797
45	ABC transporters_Homo sapiens_hsa02010	1.02858267
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.02010932
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.99044401
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.98634608
49	Basal transcription factors_Homo sapiens_hsa03022	0.95803765
50	Glutamatergic synapse_Homo sapiens_hsa04724	0.94416632
51	Serotonergic synapse_Homo sapiens_hsa04726	0.93698433
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.93048015
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.92820305
54	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.90304541
55	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.89826100
56	Cholinergic synapse_Homo sapiens_hsa04725	0.89252060
57	Insulin secretion_Homo sapiens_hsa04911	0.87338572
58	GABAergic synapse_Homo sapiens_hsa04727	0.83078241
59	Regulation of autophagy_Homo sapiens_hsa04140	0.79159942
60	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.77911823
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.77399187
62	cAMP signaling pathway_Homo sapiens_hsa04024	0.74987975
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71796943
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.69054758
65	MAPK signaling pathway_Homo sapiens_hsa04010	0.68139413
66	Salivary secretion_Homo sapiens_hsa04970	0.67576933
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64347461
68	Cardiac muscle contraction_Homo sapiens_hsa04260	0.63265616
69	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.62708725
70	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.62470721
71	Gastric acid secretion_Homo sapiens_hsa04971	0.62023928
72	Sulfur metabolism_Homo sapiens_hsa00920	0.61988099
73	RNA degradation_Homo sapiens_hsa03018	0.56773061
74	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.56562927
75	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.54708153
76	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.54019502
77	Asthma_Homo sapiens_hsa05310	0.53934790
78	Renin secretion_Homo sapiens_hsa04924	0.51879864
79	One carbon pool by folate_Homo sapiens_hsa00670	0.50873821
80	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.50660324
81	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.49692362
82	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.49434328
83	Protein digestion and absorption_Homo sapiens_hsa04974	0.48075160
84	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.47312612
85	Endocytosis_Homo sapiens_hsa04144	0.47140336
86	PPAR signaling pathway_Homo sapiens_hsa03320	0.46775952
87	Selenocompound metabolism_Homo sapiens_hsa00450	0.45947377
88	Histidine metabolism_Homo sapiens_hsa00340	0.45652463
89	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.38920910
90	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.38538659
91	Purine metabolism_Homo sapiens_hsa00230	0.38421073
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.37961078
93	Fatty acid degradation_Homo sapiens_hsa00071	0.37684569
94	Pancreatic secretion_Homo sapiens_hsa04972	0.36214241
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.35332907
96	Ether lipid metabolism_Homo sapiens_hsa00565	0.35027438
97	Peroxisome_Homo sapiens_hsa04146	0.34382143
98	Caffeine metabolism_Homo sapiens_hsa00232	0.34353149
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32605019
100	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.32044884

GTF2IP13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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