GTF2IP20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)8.82208290
2acrosome reaction (GO:0007340)8.76495984
3fusion of sperm to egg plasma membrane (GO:0007342)7.74333402
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.04208838
5sperm capacitation (GO:0048240)6.89163091
6chromosome condensation (GO:0030261)6.56662061
7DNA packaging (GO:0006323)6.51457246
8response to pheromone (GO:0019236)6.47255142
9protein targeting to Golgi (GO:0000042)6.18590208
10single strand break repair (GO:0000012)6.15163213
11establishment of protein localization to Golgi (GO:0072600)6.13071283
12phosphatidylethanolamine biosynthetic process (GO:0006646)6.05876779
13spermatid development (GO:0007286)5.95075550
14spermatid nucleus differentiation (GO:0007289)5.95029640
15retrograde transport, vesicle recycling within Golgi (GO:0000301)5.82314583
16plasma membrane fusion (GO:0045026)5.70920582
17phosphatidylethanolamine metabolic process (GO:0046337)5.62274132
18microtubule depolymerization (GO:0007019)5.54275749
19multicellular organism reproduction (GO:0032504)5.31828752
20sperm-egg recognition (GO:0035036)5.30092858
21negative regulation of inclusion body assembly (GO:0090084)5.13751839
22reproduction (GO:0000003)4.96836144
23protein polyglutamylation (GO:0018095)4.88634373
24rRNA methylation (GO:0031167)4.82896113
25sexual reproduction (GO:0019953)4.77354268
26axonemal dynein complex assembly (GO:0070286)4.64697608
27positive regulation of Rab GTPase activity (GO:0032851)4.55556042
28regulation of Rab GTPase activity (GO:0032313)4.55556042
29cell-cell recognition (GO:0009988)4.52301680
30spermatogenesis (GO:0007283)4.51262088
31binding of sperm to zona pellucida (GO:0007339)4.50441920
32male gamete generation (GO:0048232)4.49983549
33microtubule polymerization or depolymerization (GO:0031109)4.49085066
34calcium ion-dependent exocytosis (GO:0017156)4.47636954
35protein localization to Golgi apparatus (GO:0034067)4.44049638
36cilium or flagellum-dependent cell motility (GO:0001539)4.40106963
37RNA destabilization (GO:0050779)4.34148136
38centriole replication (GO:0007099)4.24289136
39gamete generation (GO:0007276)4.10388944
40regulation of T-helper 2 cell differentiation (GO:0045628)4.09483144
41microtubule severing (GO:0051013)4.09258513
42cell wall macromolecule catabolic process (GO:0016998)4.03846572
43negative regulation of Rho protein signal transduction (GO:0035024)4.00880562
44chromatin silencing (GO:0006342)3.96334997
45motile cilium assembly (GO:0044458)3.93786644
46cellular ketone body metabolic process (GO:0046950)3.92294668
47regulation of cilium movement (GO:0003352)3.89065197
48centriole assembly (GO:0098534)3.82792232
49rRNA modification (GO:0000154)3.79929261
50cell wall macromolecule metabolic process (GO:0044036)3.73024159
51histone H3-K9 demethylation (GO:0033169)3.70234197
52positive regulation by symbiont of host defense response (GO:0052509)3.60651964
53modulation by symbiont of host defense response (GO:0052031)3.60651964
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.60651964
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.60651964
56positive regulation by organism of defense response of other organism involved in symbiotic interact3.60651964
57modulation by symbiont of host immune response (GO:0052553)3.60651964
58single fertilization (GO:0007338)3.60505791
59regulation of ARF GTPase activity (GO:0032312)3.50052117
60germ cell development (GO:0007281)3.44927888
61macrophage activation involved in immune response (GO:0002281)3.42905009
62ketone body metabolic process (GO:1902224)3.40999040
63regulation of inclusion body assembly (GO:0090083)3.35785312
64multicellular organismal reproductive process (GO:0048609)3.28725263
65cellular process involved in reproduction in multicellular organism (GO:0022412)3.28609839
66regulation of gamma-delta T cell activation (GO:0046643)3.26712622
67regulation of transcription involved in cell fate commitment (GO:0060850)3.24720145
68nucleus organization (GO:0006997)3.22979805
69epithelial cilium movement (GO:0003351)3.21853957
70peptidyl-threonine dephosphorylation (GO:0035970)3.19594220
71organic cation transport (GO:0015695)3.18186256
72regulation of gamma-delta T cell differentiation (GO:0045586)3.16781513
73positive regulation of gamma-delta T cell activation (GO:0046645)3.15265093
74negative regulation of gene expression, epigenetic (GO:0045814)3.12217214
75fertilization (GO:0009566)3.05359457
76positive regulation of T cell mediated cytotoxicity (GO:0001916)3.04969941
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.04612226
78negative regulation of cell killing (GO:0031342)3.04612226
79microtubule nucleation (GO:0007020)3.00406478
80regulation of B cell receptor signaling pathway (GO:0050855)2.93563652
81seminiferous tubule development (GO:0072520)2.90766848
82regulation of somitogenesis (GO:0014807)2.90092745
83positive regulation of type 2 immune response (GO:0002830)2.88221667
84cilium movement (GO:0003341)2.88165650
85positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.84677696
86cellular extravasation (GO:0045123)2.82832340
87regulation of centriole replication (GO:0046599)2.80042395
88detection of molecule of bacterial origin (GO:0032490)2.79553323
89negative regulation of granulocyte differentiation (GO:0030853)2.75575911
90regulation of T cell mediated cytotoxicity (GO:0001914)2.74909339
91regulation of interferon-beta biosynthetic process (GO:0045357)2.69354530
92mast cell activation involved in immune response (GO:0002279)2.68657243
93mast cell degranulation (GO:0043303)2.68657243
94regulation of histone H3-K27 methylation (GO:0061085)2.68422821
95NAD biosynthetic process (GO:0009435)2.65529146
96myeloid cell activation involved in immune response (GO:0002275)2.64111787
97regulation of interleukin-13 production (GO:0032656)2.63653945
98negative regulation of histone methylation (GO:0031061)2.63187138
99musculoskeletal movement (GO:0050881)2.59890747
100multicellular organismal movement (GO:0050879)2.59890747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.81773756
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.55519967
3VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.41435654
4RUNX_20019798_ChIP-Seq_JUKART_Human2.39443891
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.39121893
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.16330680
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.12693917
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12693917
9DROSHA_22980978_ChIP-Seq_HELA_Human2.02368435
10SPI1_23127762_ChIP-Seq_K562_Human1.86061782
11SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80894534
12ELF1_20517297_ChIP-Seq_JURKAT_Human1.80688898
13BCL6_27268052_Chip-Seq_Bcells_Human1.74915927
14ERA_21632823_ChIP-Seq_H3396_Human1.72927388
15RAC3_21632823_ChIP-Seq_H3396_Human1.72423681
16EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.69762211
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69141146
18RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.68362552
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66047394
20VDR_24787735_ChIP-Seq_THP-1_Human1.65918393
21BCOR_27268052_Chip-Seq_Bcells_Human1.63348592
22NANOG_20526341_ChIP-Seq_ESCs_Human1.61834289
23ER_23166858_ChIP-Seq_MCF-7_Human1.59110053
24WDR5_24793694_ChIP-Seq_LNCAP_Human1.57102089
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57031868
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.56248810
27E2F1_20622854_ChIP-Seq_HELA_Human1.56030983
28SMC4_20622854_ChIP-Seq_HELA_Human1.53790843
29CBP_20019798_ChIP-Seq_JUKART_Human1.53551373
30IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53551373
31GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53182090
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50471010
33P68_20966046_ChIP-Seq_HELA_Human1.49239493
34PHF8_20622854_ChIP-Seq_HELA_Human1.47322815
35SCL_19346495_ChIP-Seq_HPC-7_Human1.47190276
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46470310
37P300_27268052_Chip-Seq_Bcells_Human1.45304317
38GATA1_19941826_ChIP-Seq_K562_Human1.44779020
39OCT4_20526341_ChIP-Seq_ESCs_Human1.44236471
40SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.43892971
41MYB_26560356_Chip-Seq_TH2_Human1.43182512
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39443029
43TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39341568
44SMRT_27268052_Chip-Seq_Bcells_Human1.38835655
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37750393
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36325141
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34071580
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.33901788
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33551183
50EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.31237360
51LXR_22292898_ChIP-Seq_THP-1_Human1.28557382
52TP63_22573176_ChIP-Seq_HFKS_Human1.27850397
53TAF2_19829295_ChIP-Seq_ESCs_Human1.27727227
54GATA3_27048872_Chip-Seq_THYMUS_Human1.25865253
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25123768
56MYC_19829295_ChIP-Seq_ESCs_Human1.22953612
57KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.21271871
58CEBPB_22108803_ChIP-Seq_LS180_Human1.21246433
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20837744
60CTCF_20526341_ChIP-Seq_ESCs_Human1.20677415
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.20193132
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19604046
63P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.19574693
64CTCF_27219007_Chip-Seq_Bcells_Human1.18556553
65MYB_26560356_Chip-Seq_TH1_Human1.16463081
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.15809208
67HNFA_21074721_ChIP-Seq_CACO-2_Human1.14254749
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13423488
69CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11314499
70ETV1_20927104_ChIP-Seq_GIST48_Human1.10410997
71SPI1_20517297_ChIP-Seq_HL60_Human1.10333287
72TCF7_22412390_ChIP-Seq_EML_Mouse1.09873045
73CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09845273
74OCT4_19829295_ChIP-Seq_ESCs_Human1.09685458
75RBPJ_21746931_ChIP-Seq_IB4_Human1.09588471
76BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.08268774
77MAF_26560356_Chip-Seq_TH2_Human1.07903120
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.07761096
79SA1_27219007_Chip-Seq_Bcells_Human1.07577247
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07497598
81PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06722342
82TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.05692728
83VDR_24763502_ChIP-Seq_THP-1_Human1.05204090
84GATA3_26560356_Chip-Seq_TH2_Human1.03851756
85OCT1_27270436_Chip-Seq_PROSTATE_Human1.03453073
86AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03079371
87GATA2_19941826_ChIP-Seq_K562_Human1.02114578
88MAF_26560356_Chip-Seq_TH1_Human1.01972329
89ERG_20517297_ChIP-Seq_VCAP_Human1.01833336
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.01665488
91UTX_26944678_Chip-Seq_JUKART_Human1.01202462
92GATA3_26560356_Chip-Seq_TH1_Human1.00112595
93SA1_27219007_Chip-Seq_ERYTHROID_Human0.98296302
94TBL1_22424771_ChIP-Seq_293T_Human0.98115419
95NFYB_21822215_ChIP-Seq_K562_Human0.98019465
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.97588085
97RUNX1_27514584_Chip-Seq_MCF-7_Human0.97550126
98KDM2B_26808549_Chip-Seq_DND41_Human0.96751274
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96437656
100ZNF274_21170338_ChIP-Seq_K562_Hela0.96305905

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.99863198
2MP0005377_hearing/vestibular/ear_phenot4.50920502
3MP0003878_abnormal_ear_physiology4.50920502
4MP0002132_abnormal_respiratory_system3.44367876
5MP0003698_abnormal_male_reproductive3.39448035
6MP0005670_abnormal_white_adipose3.38715630
7MP0001929_abnormal_gametogenesis2.95789049
8MP0003724_increased_susceptibility_to2.64202338
9MP0000678_abnormal_parathyroid_gland2.47848388
10MP0003436_decreased_susceptibility_to2.36496759
11MP0001348_abnormal_lacrimal_gland2.33849681
12MP0001835_abnormal_antigen_presentation2.10803210
13MP0005451_abnormal_body_composition2.09571404
14MP0005310_abnormal_salivary_gland2.07247249
15MP0003646_muscle_fatigue1.95529051
16MP0002419_abnormal_innate_immunity1.75982366
17MP0002161_abnormal_fertility/fecundity1.73900235
18MP0001800_abnormal_humoral_immune1.71896607
19MP0003172_abnormal_lysosome_physiology1.69475052
20MP0003303_peritoneal_inflammation1.67094513
21MP0005025_abnormal_response_to1.60841620
22MP0002723_abnormal_immune_serum1.54609957
23MP0009278_abnormal_bone_marrow1.52505886
24MP0000685_abnormal_immune_system1.52339158
25MP0009785_altered_susceptibility_to1.48212621
26MP0001790_abnormal_immune_system1.37911982
27MP0005387_immune_system_phenotype1.37911982
28MP0005000_abnormal_immune_tolerance1.33053742
29MP0003011_delayed_dark_adaptation1.32523487
30MP0002420_abnormal_adaptive_immunity1.32205060
31MP0002452_abnormal_antigen_presenting1.31796458
32MP0001819_abnormal_immune_cell1.30616452
33MP0001545_abnormal_hematopoietic_system1.30326950
34MP0005397_hematopoietic_system_phenotyp1.30326950
35MP0004510_myositis1.29061634
36MP0002249_abnormal_larynx_morphology1.26728419
37MP0008877_abnormal_DNA_methylation1.25823926
38MP0005671_abnormal_response_to1.23952359
39MP0002138_abnormal_hepatobiliary_system1.22013114
40MP0002405_respiratory_system_inflammati1.19851124
41MP0004381_abnormal_hair_follicle1.19311700
42MP0002210_abnormal_sex_determination1.16196975
43MP0002398_abnormal_bone_marrow1.12967689
44MP0000569_abnormal_digit_pigmentation1.12719363
45MP0009764_decreased_sensitivity_to1.11964495
46MP0001533_abnormal_skeleton_physiology1.06919353
47MP0001145_abnormal_male_reproductive1.05972648
48MP0000703_abnormal_thymus_morphology1.05798846
49MP0000716_abnormal_immune_system1.05030540
50MP0001765_abnormal_ion_homeostasis1.04761338
51MP0003656_abnormal_erythrocyte_physiolo1.03460723
52MP0003828_pulmonary_edema1.01804667
53MP0002722_abnormal_immune_system0.99994827
54MP0000653_abnormal_sex_gland0.99434201
55MP0005083_abnormal_biliary_tract0.98641502
56MP0009115_abnormal_fat_cell0.98301709
57MP0002653_abnormal_ependyma_morphology0.95380966
58MP0001485_abnormal_pinna_reflex0.94322364
59MP0002127_abnormal_cardiovascular_syste0.92712881
60MP0001486_abnormal_startle_reflex0.92401840
61MP0005379_endocrine/exocrine_gland_phen0.90410570
62MP0003718_maternal_effect0.89943408
63MP0008995_early_reproductive_senescence0.89660862
64MP0002396_abnormal_hematopoietic_system0.87916464
65MP0004742_abnormal_vestibular_system0.87285882
66MP0000689_abnormal_spleen_morphology0.86742058
67MP0003763_abnormal_thymus_physiology0.86685835
68MP0002928_abnormal_bile_duct0.85296906
69MP0001873_stomach_inflammation0.83938425
70MP0008469_abnormal_protein_level0.81684666
71MP0005248_abnormal_Harderian_gland0.81329576
72MP0000015_abnormal_ear_pigmentation0.81186821
73MP0002429_abnormal_blood_cell0.80696674
74MP0004883_abnormal_blood_vessel0.79681150
75MP0008961_abnormal_basal_metabolism0.76547967
76MP0004947_skin_inflammation0.75333508
77MP0001845_abnormal_inflammatory_respons0.75156375
78MP0004484_altered_response_of0.72976753
79MP0006082_CNS_inflammation0.71593198
80MP0005464_abnormal_platelet_physiology0.71055564
81MP0002282_abnormal_trachea_morphology0.69497933
82MP0000470_abnormal_stomach_morphology0.69389399
83MP0002822_catalepsy0.67031011
84MP0003879_abnormal_hair_cell0.64068431
85MP0005535_abnormal_body_temperature0.63733714
86MP0002229_neurodegeneration0.63041958
87MP0002277_abnormal_respiratory_mucosa0.62856924
88MP0001963_abnormal_hearing_physiology0.62707031
89MP0002735_abnormal_chemical_nociception0.62326304
90MP0005164_abnormal_response_to0.61368936
91MP0000681_abnormal_thyroid_gland0.61100671
92MP0005167_abnormal_blood-brain_barrier0.60840188
93MP0003866_abnormal_defecation0.60470747
94MP0005666_abnormal_adipose_tissue0.60466422
95MP0003045_fibrosis0.59868413
96MP0005395_other_phenotype0.59237213
97MP0003787_abnormal_imprinting0.57260967
98MP0009765_abnormal_xenobiotic_induced0.56950715
99MP0005375_adipose_tissue_phenotype0.55473894
100MP0000371_diluted_coat_color0.54486472

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.07526581
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.29623334
3Absent/shortened dynein arms (HP:0200106)5.01490048
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.01490048
5Attenuation of retinal blood vessels (HP:0007843)3.96259774
6Bony spicule pigmentary retinopathy (HP:0007737)3.92835603
7Abnormal rod and cone electroretinograms (HP:0008323)3.90739508
8Hypochromic microcytic anemia (HP:0004840)3.88594413
9Chronic hepatic failure (HP:0100626)3.84457215
10Tubulointerstitial nephritis (HP:0001970)3.72118895
11Abnormal ciliary motility (HP:0012262)3.68901914
12Nasal polyposis (HP:0100582)3.68095224
13Retrobulbar optic neuritis (HP:0100654)3.60695815
14Optic neuritis (HP:0100653)3.60695815
15Myositis (HP:0100614)3.58504983
16Asymmetric septal hypertrophy (HP:0001670)3.55523795
17Abnormal respiratory epithelium morphology (HP:0012253)3.53300762
18Abnormal respiratory motile cilium morphology (HP:0005938)3.53300762
19Abnormal respiratory motile cilium physiology (HP:0012261)3.45748895
20Orchitis (HP:0100796)3.44952302
21Resting tremor (HP:0002322)3.43414431
22Gastrointestinal infarctions (HP:0005244)3.42273750
23Hyperkalemia (HP:0002153)3.34859241
24Postural instability (HP:0002172)3.22539480
25Abnormality of macular pigmentation (HP:0008002)3.17287242
26Recurrent bacterial skin infections (HP:0005406)3.11190470
27Male infertility (HP:0003251)3.09454403
28Recurrent abscess formation (HP:0002722)3.06955372
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.03338251
30Bell-shaped thorax (HP:0001591)3.00061075
31Hypoplastic ischia (HP:0003175)2.97992148
32Gingivitis (HP:0000230)2.95436780
33Infertility (HP:0000789)2.93275719
34Eczematoid dermatitis (HP:0000976)2.92129387
35Cone-rod dystrophy (HP:0000548)2.89227586
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.86314189
37Hypoplasia of the thymus (HP:0000778)2.81743309
38Chronic obstructive pulmonary disease (HP:0006510)2.77874452
39Obstructive lung disease (HP:0006536)2.77874452
40Abnormality of the nasal mucosa (HP:0000433)2.75941983
41Hypochromic anemia (HP:0001931)2.72933487
42Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.69928997
43Impulsivity (HP:0100710)2.69041246
44Truncal obesity (HP:0001956)2.65115422
45Stomatitis (HP:0010280)2.62625635
46Recurrent gram-negative bacterial infections (HP:0005420)2.57263489
47Tetany (HP:0001281)2.54578153
48Facial shape deformation (HP:0011334)2.52955864
49Potter facies (HP:0002009)2.52955864
50Abnormality of the ischium (HP:0003174)2.49781616
51Enlarged epiphyses (HP:0010580)2.49001403
52Abnormality of macrophages (HP:0004311)2.48761783
53Progressive cerebellar ataxia (HP:0002073)2.47040876
54Keratoconjunctivitis sicca (HP:0001097)2.44213930
55Elevated erythrocyte sedimentation rate (HP:0003565)2.44043914
56Abnormality of the aortic arch (HP:0012303)2.43186047
57Abnormal spermatogenesis (HP:0008669)2.41626099
58Osteomalacia (HP:0002749)2.39994173
59Recurrent fungal infections (HP:0002841)2.37673816
60Keratoconjunctivitis (HP:0001096)2.35167554
61Peritonitis (HP:0002586)2.33532782
62Prolonged bleeding time (HP:0003010)2.29977043
63Amelogenesis imperfecta (HP:0000705)2.29040209
64Azoospermia (HP:0000027)2.28182837
65Recurrent pneumonia (HP:0006532)2.27542531
66Abnormality of the costochondral junction (HP:0000919)2.26297709
67Abnormal delayed hypersensitivity skin test (HP:0002963)2.26056680
68Recurrent skin infections (HP:0001581)2.22699849
69Abnormality of the fingertips (HP:0001211)2.22042194
70Nephronophthisis (HP:0000090)2.21214935
71Abnormal urine output (HP:0012590)2.16555141
72Portal hypertension (HP:0001409)2.15957457
73Abnormal drinking behavior (HP:0030082)2.10781519
74Polydipsia (HP:0001959)2.10781519
75Bronchiectasis (HP:0002110)2.07223788
76Meningitis (HP:0001287)2.05437284
77Aplasia/Hypoplasia of the thymus (HP:0010515)2.04730144
78Genetic anticipation (HP:0003743)2.03179799
79Recurrent cutaneous fungal infections (HP:0011370)2.01766704
80Chronic mucocutaneous candidiasis (HP:0002728)2.01766704
81Abnormality of the renal medulla (HP:0100957)1.99059974
82Stage 5 chronic kidney disease (HP:0003774)1.98038012
83Abnormality of the hepatic vasculature (HP:0006707)1.96673238
84Abnormality of dental color (HP:0011073)1.94929265
85Colitis (HP:0002583)1.91828050
86Polyuria (HP:0000103)1.91814571
87Rhinitis (HP:0012384)1.91644232
88Inflammation of the large intestine (HP:0002037)1.91331445
89Widely patent fontanelles and sutures (HP:0004492)1.90996930
90Slow saccadic eye movements (HP:0000514)1.90919930
91Increased IgE level (HP:0003212)1.89977498
92Chest pain (HP:0100749)1.89461174
93Hemoptysis (HP:0002105)1.89229326
94Abnormality of T cell physiology (HP:0011840)1.88553279
95Abnormality of renal excretion (HP:0011036)1.88430381
96Hypoalphalipoproteinemia (HP:0003233)1.85996380
97Vasculitis (HP:0002633)1.84530073
98Abnormality of potassium homeostasis (HP:0011042)1.81127007
99Encephalitis (HP:0002383)1.81069396
100Arterial thrombosis (HP:0004420)1.79487418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.32522560
2RIPK43.55985573
3STK382.89613189
4BRD42.77830599
5BLK2.57299672
6INSRR2.54300050
7TESK12.39391745
8DDR22.36400224
9TNK22.09392314
10CDK122.03805738
11FRK1.96615676
12MAP4K21.96495876
13CAMK1G1.90410757
14WNK11.85098082
15MAP4K11.80607641
16PIK3CG1.73610768
17MAPK151.65844770
18PTK2B1.65700467
19IRAK41.61826033
20TAOK31.58475511
21PDK11.55583281
22GRK61.52790625
23PLK21.51210570
24CSK1.51131589
25KSR21.50670546
26PDPK11.49958878
27MAP2K31.49602935
28SIK21.41309817
29PNCK1.34739919
30JAK31.31806272
31TYK21.28502416
32TXK1.21505761
33MARK21.21314320
34MAP3K111.17857088
35AKT31.17679521
36FES1.16485381
37STK38L1.15439787
38ERN11.13722688
39MAP3K71.13690873
40DYRK1B1.11491238
41ZAP701.09893440
42MAP3K21.08545944
43CAMK1D1.06989857
44HCK1.05088244
45MAP3K11.04848100
46BTK1.02436433
47PRKD30.97933069
48SYK0.97861048
49PRKAA20.95854248
50IKBKE0.95381966
51MARK30.92003201
52JAK20.88149504
53EPHB10.86743421
54KIT0.84875127
55SGK20.79252632
56TAOK10.72894473
57NEK60.68621786
58LYN0.67595662
59CDK70.66647273
60IKBKB0.66140931
61FGR0.66039336
62RPS6KA10.65976158
63PRKG20.65414024
64SGK4940.64824032
65SGK2230.64824032
66MAP3K30.63297329
67RPS6KA60.61675613
68RPS6KC10.60059807
69RPS6KL10.60059807
70SGK30.59735890
71NLK0.58647642
72CAMK40.56984904
73LCK0.55386691
74RPS6KA20.54986769
75ACVR1B0.54226265
76CAMK10.53787263
77YES10.50745537
78MAP3K130.50325587
79ITK0.49498298
80FGFR30.49229039
81PRKCZ0.49199218
82TEC0.49081572
83MAP2K20.47745602
84SGK10.47431926
85MAP2K60.47277022
86MAPK10.46765667
87IRAK10.45380725
88WNK40.44660198
89MATK0.42844577
90NTRK30.42330182
91MST1R0.41541779
92PRKG10.41343783
93PINK10.41117541
94CSF1R0.40457186
95PRKD20.39434762
96CHUK0.39125847
97MAPK80.39061615
98TRIB30.38864148
99STK110.38559091
100MAPK110.36176260

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.62138742
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.48251292
3Olfactory transduction_Homo sapiens_hsa047402.34129874
4Dorso-ventral axis formation_Homo sapiens_hsa043202.05355068
5Graft-versus-host disease_Homo sapiens_hsa053322.02237220
6Allograft rejection_Homo sapiens_hsa053302.01159373
7Osteoclast differentiation_Homo sapiens_hsa043801.99561544
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97377137
9Leishmaniasis_Homo sapiens_hsa051401.93938062
10Autoimmune thyroid disease_Homo sapiens_hsa053201.93310634
11Type I diabetes mellitus_Homo sapiens_hsa049401.88832375
12Glycerophospholipid metabolism_Homo sapiens_hsa005641.88218060
13Acute myeloid leukemia_Homo sapiens_hsa052211.76565953
14B cell receptor signaling pathway_Homo sapiens_hsa046621.75560339
15Type II diabetes mellitus_Homo sapiens_hsa049301.63410143
16Staphylococcus aureus infection_Homo sapiens_hsa051501.58848876
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57729214
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51533197
19Influenza A_Homo sapiens_hsa051641.50153966
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48309968
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48255626
22Adipocytokine signaling pathway_Homo sapiens_hsa049201.44124837
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.41901300
24Antigen processing and presentation_Homo sapiens_hsa046121.40833950
25Measles_Homo sapiens_hsa051621.30434912
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29670343
27T cell receptor signaling pathway_Homo sapiens_hsa046601.23961379
28Tuberculosis_Homo sapiens_hsa051521.23466161
29Inositol phosphate metabolism_Homo sapiens_hsa005621.22810370
30Butanoate metabolism_Homo sapiens_hsa006501.21106716
31Chemokine signaling pathway_Homo sapiens_hsa040621.20422613
32Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18266855
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13453583
34Primary immunodeficiency_Homo sapiens_hsa053401.11816286
35ABC transporters_Homo sapiens_hsa020101.11630823
36Herpes simplex infection_Homo sapiens_hsa051681.10819939
37Legionellosis_Homo sapiens_hsa051341.08200354
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07216481
39Viral myocarditis_Homo sapiens_hsa054161.02442545
40Non-small cell lung cancer_Homo sapiens_hsa052231.00181893
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00018820
42VEGF signaling pathway_Homo sapiens_hsa043700.99505473
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98437491
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98171659
45Malaria_Homo sapiens_hsa051440.98165289
46Toxoplasmosis_Homo sapiens_hsa051450.96723108
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.93668691
48Prolactin signaling pathway_Homo sapiens_hsa049170.92134863
49Taste transduction_Homo sapiens_hsa047420.91975530
50Endocytosis_Homo sapiens_hsa041440.89831182
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89200936
52Platelet activation_Homo sapiens_hsa046110.84838197
53African trypanosomiasis_Homo sapiens_hsa051430.83938949
54Insulin resistance_Homo sapiens_hsa049310.79553807
55Choline metabolism in cancer_Homo sapiens_hsa052310.77933822
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77906084
57FoxO signaling pathway_Homo sapiens_hsa040680.77893996
58mTOR signaling pathway_Homo sapiens_hsa041500.75668541
59Notch signaling pathway_Homo sapiens_hsa043300.73120203
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72670340
61Hematopoietic cell lineage_Homo sapiens_hsa046400.72600980
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68812807
63TNF signaling pathway_Homo sapiens_hsa046680.68519293
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67771904
65MAPK signaling pathway_Homo sapiens_hsa040100.66766283
66Hepatitis B_Homo sapiens_hsa051610.66303630
67Regulation of autophagy_Homo sapiens_hsa041400.66186519
68cAMP signaling pathway_Homo sapiens_hsa040240.64765064
69Estrogen signaling pathway_Homo sapiens_hsa049150.63646314
70Viral carcinogenesis_Homo sapiens_hsa052030.59056157
71Glycerolipid metabolism_Homo sapiens_hsa005610.58478303
72Morphine addiction_Homo sapiens_hsa050320.56542393
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.56184838
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55431505
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53043518
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.52435444
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.51634972
78Fatty acid degradation_Homo sapiens_hsa000710.50013135
79Calcium signaling pathway_Homo sapiens_hsa040200.49945742
80Salivary secretion_Homo sapiens_hsa049700.46292634
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.46106875
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45993993
83Prostate cancer_Homo sapiens_hsa052150.45293959
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.42578139
85Cholinergic synapse_Homo sapiens_hsa047250.40862058
86HIF-1 signaling pathway_Homo sapiens_hsa040660.39356152
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39196152
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37770865
89Epstein-Barr virus infection_Homo sapiens_hsa051690.37228735
90Hepatitis C_Homo sapiens_hsa051600.37106904
91Phagosome_Homo sapiens_hsa041450.36960334
92Chronic myeloid leukemia_Homo sapiens_hsa052200.36777280
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36648710
94Linoleic acid metabolism_Homo sapiens_hsa005910.34115410
95Insulin signaling pathway_Homo sapiens_hsa049100.34057317
96Lysine degradation_Homo sapiens_hsa003100.33680913
97Fatty acid metabolism_Homo sapiens_hsa012120.33570882
98Renin secretion_Homo sapiens_hsa049240.33041080
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.32195220
100Phototransduction_Homo sapiens_hsa047440.30883576

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