ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	7.15164828
2	nuclear pore complex assembly (GO:0051292)	5.57664094
3	protein polyglutamylation (GO:0018095)	5.49518359
4	negative regulation of sodium ion transport (GO:0010766)	5.45864939
5	nuclear pore organization (GO:0006999)	4.98456992
6	regulation of relaxation of muscle (GO:1901077)	4.86112112
7	intraciliary transport (GO:0042073)	4.49052269
8	sperm motility (GO:0030317)	4.42449565
9	regulation of cilium movement (GO:0003352)	4.33228917
10	centriole replication (GO:0007099)	4.30405751
11	cilium or flagellum-dependent cell motility (GO:0001539)	4.29176197
12	nephron tubule morphogenesis (GO:0072078)	4.25172972
13	nephron epithelium morphogenesis (GO:0072088)	4.25172972
14	positive regulation of muscle hypertrophy (GO:0014742)	4.18993291
15	positive regulation of cardiac muscle hypertrophy (GO:0010613)	4.18993291
16	pore complex assembly (GO:0046931)	4.13442455
17	tRNA methylation (GO:0030488)	4.10175688
18	regulation of centriole replication (GO:0046599)	4.02670056
19	cell wall macromolecule catabolic process (GO:0016998)	3.98829815
20	rRNA methylation (GO:0031167)	3.93749546
21	epithelial cilium movement (GO:0003351)	3.87189486
22	brain morphogenesis (GO:0048854)	3.85176557
23	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	3.85117406
24	protein localization to cilium (GO:0061512)	3.82444440
25	regulation of cell communication by electrical coupling (GO:0010649)	3.75689305
26	ribonucleoprotein complex disassembly (GO:0032988)	3.72759348
27	ventricular system development (GO:0021591)	3.68914088
28	centriole assembly (GO:0098534)	3.59131535
29	DNA integration (GO:0015074)	3.58213010
30	RNA methylation (GO:0001510)	3.53618275
31	microtubule severing (GO:0051013)	3.50873694
32	motile cilium assembly (GO:0044458)	3.50402456
33	cilium movement (GO:0003341)	3.49576426
34	cell wall macromolecule metabolic process (GO:0044036)	3.48115791
35	acrosome reaction (GO:0007340)	3.44655439
36	sperm-egg recognition (GO:0035036)	3.43970706
37	axonemal dynein complex assembly (GO:0070286)	3.37130020
38	organelle disassembly (GO:1903008)	3.36488241
39	COPII vesicle coating (GO:0048208)	3.36288976
40	binding of sperm to zona pellucida (GO:0007339)	3.35848861
41	DNA packaging (GO:0006323)	3.25962879
42	seminiferous tubule development (GO:0072520)	3.25528009
43	negative regulation of mRNA metabolic process (GO:1903312)	3.22028895
44	chromosome condensation (GO:0030261)	3.21595120
45	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.20100499
46	histone H3-K9 demethylation (GO:0033169)	3.19202296
47	negative regulation of mRNA processing (GO:0050686)	3.17900891
48	rRNA modification (GO:0000154)	3.16840028
49	microtubule nucleation (GO:0007020)	3.16743821
50	Golgi to endosome transport (GO:0006895)	3.16531536
51	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.14877624
52	protein targeting to Golgi (GO:0000042)	3.06227378
53	spermatid development (GO:0007286)	3.05968032
54	muscle atrophy (GO:0014889)	3.05517515
55	microtubule depolymerization (GO:0007019)	3.04381055
56	relaxation of cardiac muscle (GO:0055119)	3.00663629
57	auditory receptor cell differentiation (GO:0042491)	2.98333875
58	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.98332891
59	fusion of sperm to egg plasma membrane (GO:0007342)	2.97568556
60	ether lipid metabolic process (GO:0046485)	2.95397721
61	short-chain fatty acid metabolic process (GO:0046459)	2.92944348
62	intra-S DNA damage checkpoint (GO:0031573)	2.92860180
63	phenol-containing compound catabolic process (GO:0019336)	2.91946552
64	regulation of microtubule-based movement (GO:0060632)	2.90187747
65	axoneme assembly (GO:0035082)	2.89829900
66	establishment of protein localization to Golgi (GO:0072600)	2.89316849
67	amyloid precursor protein catabolic process (GO:0042987)	2.89211538
68	regulation of action potential (GO:0098900)	2.88896742
69	cell-cell recognition (GO:0009988)	2.88721396
70	peptidyl-glutamic acid modification (GO:0018200)	2.86151541
71	glycerol ether metabolic process (GO:0006662)	2.85377355
72	pentose metabolic process (GO:0019321)	2.83945510
73	photoreceptor cell differentiation (GO:0046530)	2.83626183
74	eye photoreceptor cell differentiation (GO:0001754)	2.83626183
75	lactate metabolic process (GO:0006089)	2.83563218
76	hormone catabolic process (GO:0042447)	2.82760301
77	RNA polyadenylation (GO:0043631)	2.81556889
78	cellular ketone body metabolic process (GO:0046950)	2.79087551
79	pyrimidine dimer repair (GO:0006290)	2.78721774
80	water-soluble vitamin biosynthetic process (GO:0042364)	2.77754774
81	regulation of RNA export from nucleus (GO:0046831)	2.75742117
82	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.70811339
83	glutamine metabolic process (GO:0006541)	2.67809543
84	membrane protein intracellular domain proteolysis (GO:0031293)	2.67017386
85	negative regulation of RNA splicing (GO:0033119)	2.65306296
86	ether metabolic process (GO:0018904)	2.65191787
87	sperm capacitation (GO:0048240)	2.63762534
88	protein localization to Golgi apparatus (GO:0034067)	2.62266279
89	regulation of histone H3-K27 methylation (GO:0061085)	2.62010442
90	meiotic cell cycle (GO:0051321)	2.61705043
91	negative regulation of histone methylation (GO:0031061)	2.61318266
92	positive regulation of histone methylation (GO:0031062)	2.58947815
93	ubiquinone biosynthetic process (GO:0006744)	2.56102314
94	positive regulation of histone H3-K4 methylation (GO:0051571)	2.55892289
95	protein export from nucleus (GO:0006611)	2.55617709
96	nucleosome disassembly (GO:0006337)	2.55273520
97	protein-DNA complex disassembly (GO:0032986)	2.55273520
98	intra-Golgi vesicle-mediated transport (GO:0006891)	2.54919349
99	thyroid hormone generation (GO:0006590)	2.52772313
100	renal tubule morphogenesis (GO:0061333)	2.52675370

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	3.43698727
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.18412439
3	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.06086449
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.01988347
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.99324520
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.62124944
7	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	2.29566179
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.29292036
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.26936331
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.25199623
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.24027809
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.16326726
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.11518761
14	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.10107629
15	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.09167300
16	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.05613556
17	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.02117298
18	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.95966427
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.95482059
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.93690545
21	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.91660246
22	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.83809624
23	CBP_20019798_ChIP-Seq_JUKART_Human	1.83809624
24	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.83385759
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.81638778
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.81634063
27	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.80580572
28	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.78975092
29	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.71504401
30	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.69984407
31	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.69942242
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66703836
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.66584864
34	GABP_19822575_ChIP-Seq_HepG2_Human	1.65281283
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64891557
36	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.60636479
37	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.56620471
38	CDX2_22108803_ChIP-Seq_LS180_Human	1.55931325
39	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.53471225
40	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.49549992
41	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.48759595
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43349633
43	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.39248837
44	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.38511993
45	FUS_26573619_Chip-Seq_HEK293_Human	1.37327819
46	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.37095106
47	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.35280792
48	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.35125985
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.33010383
50	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.32514652
51	NFYB_21822215_ChIP-Seq_K562_Human	1.28549024
52	TTF2_22483619_ChIP-Seq_HELA_Human	1.25360416
53	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.23592137
54	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.23009596
55	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.22620083
56	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.22213056
57	ELF5_23300383_ChIP-Seq_T47D_Human	1.22026103
58	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.21301877
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.21301877
60	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.20143779
61	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.18988823
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18579178
63	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.17473972
64	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.17142199
65	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.16579559
66	PHF8_20622853_ChIP-Seq_HELA_Human	1.16369949
67	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14918977
68	REST_19997604_ChIP-ChIP_NEURONS_Mouse	1.12249530
69	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	1.12068951
70	XRN2_22483619_ChIP-Seq_HELA_Human	1.10391034
71	ER_23166858_ChIP-Seq_MCF-7_Human	1.09440355
72	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.08567974
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.08012007
74	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.07614519
75	ETV1_20927104_ChIP-Seq_GIST48_Human	1.06819117
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.05077007
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05050658
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05050658
79	ERG_20517297_ChIP-Seq_VCAP_Human	1.04464014
80	DCP1A_22483619_ChIP-Seq_HELA_Human	1.04284566
81	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.03574386
82	P300_19829295_ChIP-Seq_ESCs_Human	1.02794015
83	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02389027
84	STAT3_23295773_ChIP-Seq_U87_Human	1.02382429
85	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99295295
86	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.99127784
87	TBL1_22424771_ChIP-Seq_293T_Human	0.98871125
88	NFYA_21822215_ChIP-Seq_K562_Human	0.98068938
89	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.97964986
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96035446
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.95295845
92	AR_25329375_ChIP-Seq_VCAP_Human	0.95232498
93	AR_21909140_ChIP-Seq_LNCAP_Human	0.94451208
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94101533
95	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93148614
96	KDM5A_27292631_Chip-Seq_BREAST_Human	0.93110775
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.92821542
98	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.91306306
99	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.91262275
100	GATA3_26560356_Chip-Seq_TH1_Human	0.90424700

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	6.73341802
2	MP0008057_abnormal_DNA_replication	4.56428996
3	MP0003878_abnormal_ear_physiology	4.39850080
4	MP0005377_hearing/vestibular/ear_phenot	4.39850080
5	MP0005410_abnormal_fertilization	3.09933003
6	MP0002254_reproductive_system_inflammat	3.04543539
7	MP0005084_abnormal_gallbladder_morpholo	2.83496737
8	MP0003121_genomic_imprinting	2.61990455
9	MP0008995_early_reproductive_senescence	2.39325763
10	MP0006292_abnormal_olfactory_placode	2.26131579
11	MP0001485_abnormal_pinna_reflex	2.11661427
12	MP0001984_abnormal_olfaction	2.00345994
13	MP0008058_abnormal_DNA_repair	1.86949888
14	MP0005408_hypopigmentation	1.86446250
15	MP0001661_extended_life_span	1.78265481
16	MP0001929_abnormal_gametogenesis	1.74838924
17	MP0005379_endocrine/exocrine_gland_phen	1.73767402
18	MP0005075_abnormal_melanosome_morpholog	1.73572737
19	MP0003698_abnormal_male_reproductive	1.69533248
20	MP0000372_irregular_coat_pigmentation	1.68976565
21	MP0003718_maternal_effect	1.66289335
22	MP0001764_abnormal_homeostasis	1.65375292
23	MP0003656_abnormal_erythrocyte_physiolo	1.60259680
24	MP0008877_abnormal_DNA_methylation	1.59063184
25	MP0003123_paternal_imprinting	1.56242889
26	MP0004957_abnormal_blastocyst_morpholog	1.49333972
27	MP0001293_anophthalmia	1.47533392
28	MP0004233_abnormal_muscle_weight	1.44064064
29	MP0003172_abnormal_lysosome_physiology	1.41377218
30	MP0010094_abnormal_chromosome_stability	1.40586934
31	MP0002132_abnormal_respiratory_system	1.38417618
32	MP0004043_abnormal_pH_regulation	1.37883350
33	MP0003567_abnormal_fetal_cardiomyocyte	1.37530823
34	MP0005670_abnormal_white_adipose	1.34852714
35	MP0008007_abnormal_cellular_replicative	1.34451988
36	MP0005636_abnormal_mineral_homeostasis	1.27162762
37	MP0005645_abnormal_hypothalamus_physiol	1.26676673
38	MP0003111_abnormal_nucleus_morphology	1.26140194
39	MP0002210_abnormal_sex_determination	1.23836825
40	MP0003693_abnormal_embryo_hatching	1.23626312
41	MP0002396_abnormal_hematopoietic_system	1.18390306
42	MP0002009_preneoplasia	1.18306426
43	MP0003221_abnormal_cardiomyocyte_apopto	1.17488127
44	MP0004147_increased_porphyrin_level	1.15267129
45	MP0000653_abnormal_sex_gland	1.13174332
46	MP0002161_abnormal_fertility/fecundity	1.12317440
47	MP0001915_intracranial_hemorrhage	1.12095637
48	MP0005551_abnormal_eye_electrophysiolog	1.11012385
49	MP0001145_abnormal_male_reproductive	1.08172655
50	MP0005253_abnormal_eye_physiology	1.07772787
51	MP0002653_abnormal_ependyma_morphology	1.06384593
52	MP0005220_abnormal_exocrine_pancreas	1.06316972
53	MP0005083_abnormal_biliary_tract	1.05961583
54	MP0003077_abnormal_cell_cycle	1.05899869
55	MP0001873_stomach_inflammation	1.05321859
56	MP0003943_abnormal_hepatobiliary_system	1.04390878
57	MP0002282_abnormal_trachea_morphology	1.04318376
58	MP0009697_abnormal_copulation	1.01950755
59	MP0004484_altered_response_of	1.00976544
60	MP0006036_abnormal_mitochondrial_physio	0.99906807
61	MP0006054_spinal_hemorrhage	0.98236486
62	MP0008932_abnormal_embryonic_tissue	0.98077565
63	MP0006035_abnormal_mitochondrial_morpho	0.98026059
64	MP0001986_abnormal_taste_sensitivity	0.98023925
65	MP0004133_heterotaxia	0.97712905
66	MP0005394_taste/olfaction_phenotype	0.94757040
67	MP0005499_abnormal_olfactory_system	0.94757040
68	MP0003136_yellow_coat_color	0.93740330
69	MP0002139_abnormal_hepatobiliary_system	0.93451398
70	MP0008789_abnormal_olfactory_epithelium	0.93026585
71	MP0004197_abnormal_fetal_growth/weight/	0.91927310
72	MP0005332_abnormal_amino_acid	0.85798424
73	MP0004885_abnormal_endolymph	0.85084909
74	MP0004264_abnormal_extraembryonic_tissu	0.83551113
75	MP0010329_abnormal_lipoprotein_level	0.82791308
76	MP0000371_diluted_coat_color	0.82543271
77	MP0005451_abnormal_body_composition	0.82360581
78	MP0001286_abnormal_eye_development	0.82158122
79	MP0003646_muscle_fatigue	0.80459599
80	MP0005365_abnormal_bile_salt	0.80297523
81	MP0001672_abnormal_embryogenesis/_devel	0.80136106
82	MP0005380_embryogenesis_phenotype	0.80136106
83	MP0005391_vision/eye_phenotype	0.78374137
84	MP0001666_abnormal_nutrient_absorption	0.76558635
85	MP0003786_premature_aging	0.76024487
86	MP0003984_embryonic_growth_retardation	0.75493102
87	MP0002088_abnormal_embryonic_growth/wei	0.73830526
88	MP0009115_abnormal_fat_cell	0.73522012
89	MP0001963_abnormal_hearing_physiology	0.73192975
90	MP0000358_abnormal_cell_content/	0.70982346
91	MP0009780_abnormal_chondrocyte_physiolo	0.65230837
92	MP0001486_abnormal_startle_reflex	0.63889892
93	MP0001697_abnormal_embryo_size	0.62911110
94	MP0002269_muscular_atrophy	0.61778436
95	MP0000609_abnormal_liver_physiology	0.61624271
96	MP0003787_abnormal_imprinting	0.61197293
97	MP0002138_abnormal_hepatobiliary_system	0.60951072
98	MP0003385_abnormal_body_wall	0.60710356
99	MP0003011_delayed_dark_adaptation	0.59362193
100	MP0002909_abnormal_adrenal_gland	0.58202136

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Tubulointerstitial nephritis (HP:0001970)	6.74531696
2	Zonular cataract (HP:0010920)	5.16367110
3	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.58128360
4	Abnormal rod and cone electroretinograms (HP:0008323)	3.49795663
5	Absent/shortened dynein arms (HP:0200106)	3.42432088
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.42432088
7	Chronic hepatic failure (HP:0100626)	3.37366913
8	Congenital malformation of the right heart (HP:0011723)	3.13851567
9	Double outlet right ventricle (HP:0001719)	3.13851567
10	Curly hair (HP:0002212)	3.08501170
11	Chromsome breakage (HP:0040012)	3.01500657
12	Hyperkalemia (HP:0002153)	3.00382214
13	Nephronophthisis (HP:0000090)	2.98084688
14	Abnormality of cochlea (HP:0000375)	2.94470106
15	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.91640266
16	Renal cortical cysts (HP:0000803)	2.83148655
17	Hypoalphalipoproteinemia (HP:0003233)	2.80651063
18	Abnormal ciliary motility (HP:0012262)	2.75190098
19	Amelogenesis imperfecta (HP:0000705)	2.74549179
20	Hypoplasia of the thymus (HP:0000778)	2.70711483
21	Abnormal respiratory epithelium morphology (HP:0012253)	2.67605007
22	Abnormal respiratory motile cilium morphology (HP:0005938)	2.67605007
23	Acute lymphatic leukemia (HP:0006721)	2.66484153
24	Truncus arteriosus (HP:0001660)	2.61379298
25	Abnormal respiratory motile cilium physiology (HP:0012261)	2.59958361
26	Abnormality of the parathyroid morphology (HP:0011766)	2.58359560
27	Stage 5 chronic kidney disease (HP:0003774)	2.44807555
28	Morphological abnormality of the inner ear (HP:0011390)	2.43517849
29	Methylmalonic acidemia (HP:0002912)	2.41706753
30	Tubulointerstitial abnormality (HP:0001969)	2.39994049
31	Hypophosphatemic rickets (HP:0004912)	2.39675754
32	Congenital primary aphakia (HP:0007707)	2.38452985
33	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.36533814
34	Medial flaring of the eyebrow (HP:0010747)	2.32907629
35	Resting tremor (HP:0002322)	2.31176663
36	Constricted visual fields (HP:0001133)	2.30503994
37	Abnormality of macular pigmentation (HP:0008002)	2.29561353
38	True hermaphroditism (HP:0010459)	2.28671026
39	Abnormality of the renal medulla (HP:0100957)	2.26769401
40	Delayed CNS myelination (HP:0002188)	2.26562835
41	Renovascular hypertension (HP:0100817)	2.23812523
42	Short tibia (HP:0005736)	2.21217447
43	Abnormality of dental color (HP:0011073)	2.19444241
44	Cone-rod dystrophy (HP:0000548)	2.15505779
45	Gait imbalance (HP:0002141)	2.15054236
46	Poor coordination (HP:0002370)	2.12525713
47	Hyperglycinemia (HP:0002154)	2.07177732
48	Pancreatic fibrosis (HP:0100732)	2.04815636
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.03293488
50	Hypoparathyroidism (HP:0000829)	2.02413485
51	Hypolipoproteinemia (HP:0010981)	1.99575550
52	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.98694179
53	Flattened epiphyses (HP:0003071)	1.98409644
54	Abnormality of methionine metabolism (HP:0010901)	1.96371813
55	Abnormality of vitamin B metabolism (HP:0004340)	1.93874541
56	Dyschromatopsia (HP:0007641)	1.91898085
57	Male infertility (HP:0003251)	1.91711362
58	Long clavicles (HP:0000890)	1.91396300
59	Bony spicule pigmentary retinopathy (HP:0007737)	1.91302502
60	Growth hormone deficiency (HP:0000824)	1.89873243
61	Abnormality of vitamin metabolism (HP:0100508)	1.89529043
62	Pancreatic cysts (HP:0001737)	1.89137986
63	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.88782362
64	Postaxial foot polydactyly (HP:0001830)	1.86177878
65	Symptomatic seizures (HP:0011145)	1.84916325
66	Cubitus valgus (HP:0002967)	1.83331718
67	Chronic bronchitis (HP:0004469)	1.82635690
68	Nephrogenic diabetes insipidus (HP:0009806)	1.82036180
69	Meckel diverticulum (HP:0002245)	1.81348970
70	Vitreoretinal degeneration (HP:0000655)	1.80415422
71	Hepatoblastoma (HP:0002884)	1.80231589
72	Osteomalacia (HP:0002749)	1.79810296
73	Abnormality of glycolysis (HP:0004366)	1.79437592
74	Genital tract atresia (HP:0001827)	1.78951412
75	Obsessive-compulsive behavior (HP:0000722)	1.77740295
76	Corneal dystrophy (HP:0001131)	1.77523474
77	Pancreatic islet-cell hyperplasia (HP:0004510)	1.77149961
78	Hypoglycemic coma (HP:0001325)	1.75147080
79	Attenuation of retinal blood vessels (HP:0007843)	1.74754998
80	Abnormality of the ileum (HP:0001549)	1.74623416
81	Abnormality of DNA repair (HP:0003254)	1.74268428
82	Absent epiphyses (HP:0010577)	1.73629188
83	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.73629188
84	Increased serum pyruvate (HP:0003542)	1.73515771
85	Thyroid carcinoma (HP:0002890)	1.73341975
86	Submucous cleft hard palate (HP:0000176)	1.72607442
87	Hyponatremia (HP:0002902)	1.71863358
88	Rhinitis (HP:0012384)	1.71704785
89	Hypoglycemic seizures (HP:0002173)	1.71513671
90	Seborrheic dermatitis (HP:0001051)	1.70433830
91	Subcapsular cataract (HP:0000523)	1.69144168
92	Cerebral hypomyelination (HP:0006808)	1.68618739
93	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.68520298
94	Lower limb hyperreflexia (HP:0002395)	1.68260765
95	Cholecystitis (HP:0001082)	1.67575838
96	Abnormal gallbladder physiology (HP:0012438)	1.67575838
97	Abnormality of the renal cortex (HP:0011035)	1.66614486
98	Methylmalonic aciduria (HP:0012120)	1.65216158
99	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.64476768
100	Microvesicular hepatic steatosis (HP:0001414)	1.64086110

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	4.74177241
2	BRD4	4.06269033
3	TRIM28	3.99187267
4	PLK4	3.76203344
5	SRPK1	2.89309218
6	BCKDK	2.78443964
7	BCR	2.59402941
8	SIK3	2.28014173
9	CSNK1A1L	2.24693647
10	PLK2	2.15216679
11	CSNK1G3	2.13268980
12	PINK1	1.95756111
13	CSNK1G1	1.92855441
14	NEK1	1.86484572
15	RIPK4	1.85826346
16	EIF2AK1	1.82119804
17	INSRR	1.79832237
18	STK39	1.60134976
19	FRK	1.49190977
20	PBK	1.47901602
21	WNK4	1.43485785
22	CSNK1G2	1.42237020
23	STK24	1.29609160
24	MAP3K12	1.29446382
25	TEC	1.28124985
26	TNIK	1.23388176
27	DYRK3	1.22468247
28	RPS6KB1	1.17935742
29	TTK	1.17550103
30	MAP3K6	1.16628941
31	MST4	1.15864921
32	LIMK1	1.12360782
33	RPS6KA4	1.10263152
34	MAP2K4	1.06669402
35	ERBB3	1.05892411
36	MAP4K2	1.02319815
37	BMPR2	0.99837038
38	PDK2	0.98411859
39	TRPM7	0.97676006
40	KSR2	0.95657842
41	STK16	0.94678328
42	EEF2K	0.93190764
43	BTK	0.91603058
44	YES1	0.90150428
45	MST1R	0.85342411
46	FGFR1	0.84139803
47	PTK2B	0.83777046
48	PASK	0.83705959
49	DYRK1B	0.82364171
50	PLK3	0.82297999
51	AKT3	0.79912537
52	FER	0.79577716
53	CAMK2D	0.79493256
54	PNCK	0.79392163
55	PIK3CG	0.77530843
56	MAP3K2	0.77382963
57	MAPK15	0.77292491
58	CDK7	0.76237979
59	CDK3	0.75483985
60	CDK12	0.75336623
61	ICK	0.75074465
62	WNK1	0.73075425
63	CDK9	0.71249658
64	ATR	0.70833767
65	FLT3	0.65795426
66	BRSK2	0.64824466
67	KSR1	0.64612896
68	MKNK1	0.63921222
69	EIF2AK3	0.63590291
70	TAOK3	0.62437544
71	CAMK1G	0.61793436
72	PAK3	0.61700211
73	MAPKAPK3	0.61277067
74	STK38L	0.58260321
75	CHEK1	0.57164148
76	MAP3K5	0.56241374
77	GRK1	0.55260799
78	MAP3K4	0.53078949
79	VRK1	0.48991264
80	CSNK2A2	0.48773994
81	ATM	0.48125368
82	PRKAA2	0.47732114
83	CDK2	0.46676085
84	TNK2	0.46664950
85	CDK1	0.46378179
86	IRAK2	0.44705040
87	PIK3CA	0.44317494
88	MAPK9	0.43836803
89	OXSR1	0.43429826
90	NEK6	0.42371164
91	ITK	0.40785667
92	CSNK2A1	0.40761291
93	MTOR	0.39069831
94	CSNK1E	0.39029548
95	RPS6KB2	0.38821810
96	ZAK	0.38313391
97	MATK	0.38212017
98	BRSK1	0.37060956
99	BMX	0.36190223
100	MAPK10	0.34144596

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Propanoate metabolism_Homo sapiens_hsa00640	3.01531672
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.93649286
3	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.83717656
4	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.55638338
5	Protein export_Homo sapiens_hsa03060	2.35936875
6	RNA transport_Homo sapiens_hsa03013	2.18786262
7	Butanoate metabolism_Homo sapiens_hsa00650	2.18622686
8	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.10467111
9	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.07620303
10	Olfactory transduction_Homo sapiens_hsa04740	2.05512946
11	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.94926078
12	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.87886204
13	Base excision repair_Homo sapiens_hsa03410	1.86852798
14	One carbon pool by folate_Homo sapiens_hsa00670	1.83046267
15	Non-homologous end-joining_Homo sapiens_hsa03450	1.82765220
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.70182113
17	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.70091776
18	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.64984098
19	Carbon metabolism_Homo sapiens_hsa01200	1.59615941
20	Fatty acid metabolism_Homo sapiens_hsa01212	1.58774197
21	Steroid biosynthesis_Homo sapiens_hsa00100	1.56563630
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.46151216
23	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.46057118
24	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.45988938
25	Homologous recombination_Homo sapiens_hsa03440	1.43121504
26	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.42971831
27	Arginine biosynthesis_Homo sapiens_hsa00220	1.41512831
28	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.41461096
29	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.41083381
30	Spliceosome_Homo sapiens_hsa03040	1.39869507
31	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.38779662
32	Fatty acid elongation_Homo sapiens_hsa00062	1.36357756
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.35805677
34	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.35533915
35	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.35175964
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30718417
37	mRNA surveillance pathway_Homo sapiens_hsa03015	1.30669782
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.29362393
39	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.26778276
40	ABC transporters_Homo sapiens_hsa02010	1.25102934
41	Peroxisome_Homo sapiens_hsa04146	1.24279253
42	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.19887584
43	Mismatch repair_Homo sapiens_hsa03430	1.19355334
44	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17691771
45	Pyruvate metabolism_Homo sapiens_hsa00620	1.17435222
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.16702407
47	Fatty acid degradation_Homo sapiens_hsa00071	1.11851492
48	RNA polymerase_Homo sapiens_hsa03020	1.11359064
49	Fat digestion and absorption_Homo sapiens_hsa04975	1.10853913
50	DNA replication_Homo sapiens_hsa03030	1.04620670
51	Nucleotide excision repair_Homo sapiens_hsa03420	1.02262979
52	Glucagon signaling pathway_Homo sapiens_hsa04922	1.00555068
53	Lysine degradation_Homo sapiens_hsa00310	0.98536882
54	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.96483357
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.91908520
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.91347961
57	Oocyte meiosis_Homo sapiens_hsa04114	0.89013516
58	Basal transcription factors_Homo sapiens_hsa03022	0.85752118
59	Glioma_Homo sapiens_hsa05214	0.85270863
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78769990
61	Metabolic pathways_Homo sapiens_hsa01100	0.74074516
62	Retinol metabolism_Homo sapiens_hsa00830	0.72471441
63	Purine metabolism_Homo sapiens_hsa00230	0.71214914
64	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.70590545
65	RNA degradation_Homo sapiens_hsa03018	0.68857479
66	Sulfur metabolism_Homo sapiens_hsa00920	0.68540112
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.64772483
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64388129
69	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.61253469
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59183222
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58895301
72	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.58654336
73	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57876429
74	Vibrio cholerae infection_Homo sapiens_hsa05110	0.57682935
75	Non-small cell lung cancer_Homo sapiens_hsa05223	0.57497328
76	Circadian rhythm_Homo sapiens_hsa04710	0.57312273
77	Glutathione metabolism_Homo sapiens_hsa00480	0.56932175
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.51682458
79	p53 signaling pathway_Homo sapiens_hsa04115	0.51203531
80	Huntingtons disease_Homo sapiens_hsa05016	0.50507094
81	Cell cycle_Homo sapiens_hsa04110	0.49309861
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49175707
83	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.48886357
84	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.48662835
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.47625554
86	Insulin secretion_Homo sapiens_hsa04911	0.47044844
87	Choline metabolism in cancer_Homo sapiens_hsa05231	0.46342803
88	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.46301422
89	ErbB signaling pathway_Homo sapiens_hsa04012	0.44662895
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.44441488
91	Ether lipid metabolism_Homo sapiens_hsa00565	0.39711043
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39666311
93	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.37363481
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36378951
95	Pentose phosphate pathway_Homo sapiens_hsa00030	0.35540796
96	Taste transduction_Homo sapiens_hsa04742	0.34906462
97	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.33403337
98	Long-term potentiation_Homo sapiens_hsa04720	0.32919624
99	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.32466243
100	Amphetamine addiction_Homo sapiens_hsa05031	0.29631778

GTF2IP23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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