ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.25533736
2	regulation of synaptic vesicle exocytosis (GO:2000300)	4.23893902
3	layer formation in cerebral cortex (GO:0021819)	4.00575911
4	synaptic vesicle maturation (GO:0016188)	3.89769319
5	cerebellar granule cell differentiation (GO:0021707)	3.63453636
6	presynaptic membrane assembly (GO:0097105)	3.63204356
7	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.62473061
8	L-amino acid import (GO:0043092)	3.60217401
9	sodium ion export (GO:0071436)	3.55819782
10	locomotory exploration behavior (GO:0035641)	3.53263101
11	amino acid import (GO:0043090)	3.50439962
12	apical protein localization (GO:0045176)	3.46426294
13	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.39126567
14	vocalization behavior (GO:0071625)	3.37004751
15	postsynaptic membrane organization (GO:0001941)	3.33041084
16	glutamate secretion (GO:0014047)	3.31106891
17	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.29918809
18	presynaptic membrane organization (GO:0097090)	3.29773770
19	paraxial mesoderm development (GO:0048339)	3.26846030
20	regulation of synaptic vesicle transport (GO:1902803)	3.18447625
21	cell communication by electrical coupling (GO:0010644)	3.15838420
22	regulation of neuronal synaptic plasticity (GO:0048168)	3.15720408
23	regulation of ARF protein signal transduction (GO:0032012)	3.15569815
24	cellular potassium ion homeostasis (GO:0030007)	3.10927536
25	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	3.09539665
26	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.04721784
27	negative regulation of dendrite morphogenesis (GO:0050774)	3.01464879
28	neuron cell-cell adhesion (GO:0007158)	2.98764148
29	exploration behavior (GO:0035640)	2.98566873
30	establishment of nucleus localization (GO:0040023)	2.97566853
31	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.92785189
32	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.87575457
33	cell migration in hindbrain (GO:0021535)	2.87099866
34	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.83928319
35	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.80538669
36	regulation of long-term neuronal synaptic plasticity (GO:0048169)	2.78424521
37	neuronal ion channel clustering (GO:0045161)	2.76811546
38	regulation of NFAT protein import into nucleus (GO:0051532)	2.75956718
39	synaptic vesicle exocytosis (GO:0016079)	2.74494331
40	neurotransmitter-gated ion channel clustering (GO:0072578)	2.73408459
41	neuron recognition (GO:0008038)	2.72678887
42	neuromuscular process controlling balance (GO:0050885)	2.71203178
43	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.69851344
44	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.68957791
45	mating behavior (GO:0007617)	2.68003660
46	axonal fasciculation (GO:0007413)	2.64596722
47	suckling behavior (GO:0001967)	2.59892107
48	axon ensheathment in central nervous system (GO:0032291)	2.56625579
49	central nervous system myelination (GO:0022010)	2.56625579
50	neurotransmitter secretion (GO:0007269)	2.54337399
51	asymmetric protein localization (GO:0008105)	2.53453528
52	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.51127554
53	dendrite morphogenesis (GO:0048813)	2.50559948
54	cellular response to prostaglandin stimulus (GO:0071379)	2.49975686
55	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.45898079
56	regulation of glutamate receptor signaling pathway (GO:1900449)	2.44966449
57	innervation (GO:0060384)	2.42119292
58	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.42093585
59	embryonic camera-type eye morphogenesis (GO:0048596)	2.41068206
60	pyrimidine nucleobase catabolic process (GO:0006208)	2.40021902
61	convergent extension (GO:0060026)	2.38886315
62	potassium ion homeostasis (GO:0055075)	2.38091028
63	notochord development (GO:0030903)	2.37370307
64	ectodermal placode formation (GO:0060788)	2.35917527
65	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	2.33891899
66	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	2.33605749
67	establishment of mitochondrion localization (GO:0051654)	2.33233567
68	establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)	2.33142970
69	regulation of synaptic plasticity (GO:0048167)	2.33093810
70	central nervous system projection neuron axonogenesis (GO:0021952)	2.31720242
71	regulation of Rac protein signal transduction (GO:0035020)	2.31454094
72	clathrin coat assembly (GO:0048268)	2.28356406
73	neuron projection regeneration (GO:0031102)	2.27098176
74	axon extension (GO:0048675)	2.26910027
75	regulation of catenin import into nucleus (GO:0035412)	2.26740483
76	embryonic foregut morphogenesis (GO:0048617)	2.26602098
77	regulation of nucleobase-containing compound transport (GO:0032239)	2.26342954
78	astrocyte development (GO:0014002)	2.26216249
79	regulation of establishment of planar polarity (GO:0090175)	2.25662285
80	developmental cell growth (GO:0048588)	2.25189175
81	cellular response to monoamine stimulus (GO:0071868)	2.24701123
82	cellular response to catecholamine stimulus (GO:0071870)	2.24701123
83	establishment or maintenance of bipolar cell polarity (GO:0061245)	2.24593779
84	establishment or maintenance of apical/basal cell polarity (GO:0035088)	2.24593779
85	histone H3-K9 demethylation (GO:0033169)	2.24420397
86	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.24416378
87	regulation of dendritic spine morphogenesis (GO:0061001)	2.23549606
88	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.23307537
89	regulation of dendrite morphogenesis (GO:0048814)	2.22667174
90	adherens junction assembly (GO:0034333)	2.22585800
91	long-term memory (GO:0007616)	2.21849499
92	nerve growth factor signaling pathway (GO:0038180)	2.21528787
93	positive regulation of catenin import into nucleus (GO:0035413)	2.21338655
94	peptidyl-threonine phosphorylation (GO:0018107)	2.20575242
95	positive regulation of glucose transport (GO:0010828)	2.20060221
96	negative regulation of fibroblast apoptotic process (GO:2000270)	2.19766568
97	membrane assembly (GO:0071709)	2.19377032
98	peptidyl-threonine modification (GO:0018210)	2.19290082
99	pre-miRNA processing (GO:0031054)	2.19236393
100	cellular sodium ion homeostasis (GO:0006883)	2.18419278

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.00729629
2	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.91944993
3	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.61780800
4	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	2.58803935
5	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	2.50255603
6	ZFP281_18757296_ChIP-ChIP_E14_Mouse	2.46856012
7	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.28643838
8	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	2.26251000
9	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	2.14771668
10	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	2.09489283
11	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	2.04088183
12	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	2.00112970
13	CLOCK_20551151_ChIP-Seq_293T_Human	1.98211947
14	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.96822314
15	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.91759956
16	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.90095426
17	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.89801181
18	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.86521675
19	DROSHA_22980978_ChIP-Seq_HELA_Human	1.82660076
20	KDM2B_26808549_Chip-Seq_K562_Human	1.80190343
21	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.77743598
22	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.74946472
23	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.72981418
24	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.72981418
25	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.72981418
26	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.68959982
27	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.68959982
28	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.68332104
29	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.64510675
30	EZH2_22144423_ChIP-Seq_EOC_Human	1.61155909
31	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.58861375
32	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.58173878
33	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.57746574
34	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.52735965
35	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.52421724
36	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.51478872
37	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.51250303
38	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.49219933
39	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.47876232
40	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.44596357
41	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.41738191
42	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.41699920
43	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.41617052
44	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.41280743
45	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.40510884
46	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.40093252
47	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.36901380
48	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.34830361
49	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.32411270
50	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.29991137
51	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.27283594
52	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.26307552
53	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.25986684
54	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.25852759
55	GBX2_23144817_ChIP-Seq_PC3_Human	1.25666396
56	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	1.24318029
57	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.23919719
58	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.21752927
59	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.21179721
60	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.19544939
61	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.19301575
62	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.17701025
63	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.17178629
64	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.17061975
65	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.16822166
66	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.16331318
67	TCF7_22412390_ChIP-Seq_EML_Mouse	1.15533067
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14487850
69	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.14024205
70	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.13538751
71	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.13479651
72	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.13383506
73	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.12909173
74	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.11978559
75	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.11812691
76	POU5F1_16518401_ChIP-PET_MESCs_Mouse	1.09612732
77	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.09038938
78	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.08545680
79	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.07887201
80	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.03301999
81	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.03090295
82	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.02132748
83	KDM2B_26808549_Chip-Seq_DND41_Human	1.02115616
84	TCF3_18692474_ChIP-Seq_MESCs_Mouse	1.02044134
85	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.01351095
86	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00845277
87	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.00251255
88	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.99585046
89	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.99134199
90	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.98920719
91	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.98590226
92	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.98574756
93	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.98545827
94	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.98366263
95	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.96992940
96	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.96825169
97	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.96614412
98	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.95734456
99	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.94686751
100	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.92481492

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.77439629
2	MP0004270_analgesia	3.81746490
3	MP0003705_abnormal_hypodermis_morpholog	3.11033883
4	MP0003122_maternal_imprinting	2.36748003
5	MP0003635_abnormal_synaptic_transmissio	2.34655439
6	MP0005409_darkened_coat_color	2.30791309
7	MP0003880_abnormal_central_pattern	2.16678836
8	MP0000778_abnormal_nervous_system	2.13736785
9	MP0003329_amyloid_beta_deposits	2.11866587
10	MP0001177_atelectasis	2.07312244
11	MP0003690_abnormal_glial_cell	2.06067078
12	MP0005423_abnormal_somatic_nervous	2.02256067
13	MP0002734_abnormal_mechanical_nocicepti	2.00327497
14	MP0009780_abnormal_chondrocyte_physiolo	1.98255763
15	MP0003283_abnormal_digestive_organ	1.79914370
16	MP0002063_abnormal_learning/memory/cond	1.78501553
17	MP0000566_synostosis	1.74816347
18	MP0002822_catalepsy	1.73423939
19	MP0001486_abnormal_startle_reflex	1.71884742
20	MP0009672_abnormal_birth_weight	1.69257332
21	MP0005248_abnormal_Harderian_gland	1.66613418
22	MP0000462_abnormal_digestive_system	1.66227504
23	MP0005076_abnormal_cell_differentiation	1.59991007
24	MP0003890_abnormal_embryonic-extraembry	1.56916830
25	MP0003123_paternal_imprinting	1.56386731
26	MP0001299_abnormal_eye_distance/	1.55674531
27	MP0003634_abnormal_glial_cell	1.54201860
28	MP0000428_abnormal_craniofacial_morphol	1.53446251
29	MP0000537_abnormal_urethra_morphology	1.51566533
30	MP0008569_lethality_at_weaning	1.49544586
31	MP0002064_seizures	1.48736053
32	MP0000955_abnormal_spinal_cord	1.48004203
33	MP0004811_abnormal_neuron_physiology	1.44543521
34	MP0003115_abnormal_respiratory_system	1.42162598
35	MP0000920_abnormal_myelination	1.41657922
36	MP0003861_abnormal_nervous_system	1.37830397
37	MP0000534_abnormal_ureter_morphology	1.35429523
38	MP0008438_abnormal_cutaneous_collagen	1.34606207
39	MP0003119_abnormal_digestive_system	1.34030374
40	MP0004885_abnormal_endolymph	1.32993842
41	MP0004858_abnormal_nervous_system	1.32889103
42	MP0001849_ear_inflammation	1.32819064
43	MP0002152_abnormal_brain_morphology	1.28174286
44	MP0010030_abnormal_orbit_morphology	1.26890448
45	MP0001915_intracranial_hemorrhage	1.26442405
46	MP0002249_abnormal_larynx_morphology	1.25961492
47	MP0002735_abnormal_chemical_nociception	1.25654386
48	MP0009703_decreased_birth_body	1.24327398
49	MP0003566_abnormal_cell_adhesion	1.17548893
50	MP0001958_emphysema	1.17228714
51	MP0003632_abnormal_nervous_system	1.15235239
52	MP0010352_gastrointestinal_tract_polyps	1.14790902
53	MP0003385_abnormal_body_wall	1.14569868
54	MP0002089_abnormal_postnatal_growth/wei	1.13802795
55	MP0002572_abnormal_emotion/affect_behav	1.11821555
56	MP0005623_abnormal_meninges_morphology	1.11032229
57	MP0010234_abnormal_vibrissa_follicle	1.10031138
58	MP0003942_abnormal_urinary_system	1.09028982
59	MP0002233_abnormal_nose_morphology	1.08961667
60	MP0002882_abnormal_neuron_morphology	1.07924807
61	MP0003183_abnormal_peptide_metabolism	1.05306988
62	MP0002184_abnormal_innervation	1.03506138
63	MP0002084_abnormal_developmental_patter	1.02530403
64	MP0003121_genomic_imprinting	1.02306065
65	MP0002697_abnormal_eye_size	1.02251136
66	MP0004272_abnormal_basement_membrane	1.01012442
67	MP0003935_abnormal_craniofacial_develop	1.00152894
68	MP0002133_abnormal_respiratory_system	0.98749544
69	MP0005388_respiratory_system_phenotype	0.98749544
70	MP0001188_hyperpigmentation	0.97954168
71	MP0003938_abnormal_ear_development	0.96415273
72	MP0003787_abnormal_imprinting	0.95743855
73	MP0010368_abnormal_lymphatic_system	0.95050426
74	MP0009384_cardiac_valve_regurgitation	0.93362961
75	MP0002909_abnormal_adrenal_gland	0.93287202
76	MP0002272_abnormal_nervous_system	0.92626614
77	MP0002081_perinatal_lethality	0.92574935
78	MP0005257_abnormal_intraocular_pressure	0.92453147
79	MP0001730_embryonic_growth_arrest	0.90956029
80	MP0000579_abnormal_nail_morphology	0.90851468
81	MP0009745_abnormal_behavioral_response	0.90705460
82	MP0004264_abnormal_extraembryonic_tissu	0.90280440
83	MP0002896_abnormal_bone_mineralization	0.89246720
84	MP0002066_abnormal_motor_capabilities/c	0.89115369
85	MP0001984_abnormal_olfaction	0.89087937
86	MP0002085_abnormal_embryonic_tissue	0.88639459
87	MP0000432_abnormal_head_morphology	0.88451705
88	MP0003091_abnormal_cell_migration	0.88115228
89	MP0003631_nervous_system_phenotype	0.87122706
90	MP0002092_abnormal_eye_morphology	0.86658557
91	MP0003633_abnormal_nervous_system	0.86557848
92	MP0008260_abnormal_autophagy	0.85254625
93	MP0003941_abnormal_skin_development	0.84937413
94	MP0003937_abnormal_limbs/digits/tail_de	0.81875177
95	MP0002116_abnormal_craniofacial_bone	0.80607026
96	MP0002557_abnormal_social/conspecific_i	0.78105326
97	MP0001943_abnormal_respiration	0.76772477
98	MP0002009_preneoplasia	0.74152024
99	MP0002067_abnormal_sensory_capabilities	0.72840107
100	MP0004197_abnormal_fetal_growth/weight/	0.72341054

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperacusis (HP:0010780)	3.14851093
2	Insomnia (HP:0100785)	2.94345317
3	Arterial tortuosity (HP:0005116)	2.78254275
4	Ankle clonus (HP:0011448)	2.74679264
5	Obstructive sleep apnea (HP:0002870)	2.73557860
6	Neurofibrillary tangles (HP:0002185)	2.72862367
7	Vascular tortuosity (HP:0004948)	2.72659498
8	Overriding aorta (HP:0002623)	2.64176058
9	Arnold-Chiari malformation (HP:0002308)	2.58487679
10	Bowel diverticulosis (HP:0005222)	2.56795338
11	Turricephaly (HP:0000262)	2.55109731
12	Papillary thyroid carcinoma (HP:0002895)	2.41604024
13	Neonatal short-limb short stature (HP:0008921)	2.41293326
14	Renovascular hypertension (HP:0100817)	2.41291470
15	Action tremor (HP:0002345)	2.39578944
16	Protrusio acetabuli (HP:0003179)	2.38144270
17	Renal duplication (HP:0000075)	2.34362042
18	Increased nuchal translucency (HP:0010880)	2.28494720
19	Lower limb asymmetry (HP:0100559)	2.27564559
20	Elfin facies (HP:0004428)	2.26298162
21	Focal motor seizures (HP:0011153)	2.24459048
22	Cerebral inclusion bodies (HP:0100314)	2.20539746
23	Abnormality of the lower motor neuron (HP:0002366)	2.17722950
24	Aplasia involving bones of the upper limbs (HP:0009823)	2.17340683
25	Aplasia of the phalanges of the hand (HP:0009802)	2.17340683
26	Aplasia involving bones of the extremities (HP:0009825)	2.17340683
27	Spastic gait (HP:0002064)	2.17289217
28	Shallow orbits (HP:0000586)	2.17126865
29	Megalencephaly (HP:0001355)	2.16994749
30	Bladder diverticulum (HP:0000015)	2.10631087
31	Asymmetry of the thorax (HP:0001555)	2.10623158
32	Bronchomalacia (HP:0002780)	2.10447206
33	Vertebral arch anomaly (HP:0008438)	2.06836264
34	Termporal pattern (HP:0011008)	2.06056473
35	Insidious onset (HP:0003587)	2.06056473
36	Urinary urgency (HP:0000012)	2.05944171
37	Hepatoblastoma (HP:0002884)	2.05689703
38	Peripheral hypomyelination (HP:0007182)	2.04388717
39	Focal seizures (HP:0007359)	2.03706927
40	Vitreoretinal degeneration (HP:0000655)	2.03139960
41	Ankyloglossia (HP:0010296)	2.01127951
42	Abnormality of the corticospinal tract (HP:0002492)	1.96691762
43	Hand muscle atrophy (HP:0009130)	1.95601214
44	Hammertoe (HP:0001765)	1.95074307
45	Supranuclear gaze palsy (HP:0000605)	1.95035429
46	Impaired vibration sensation in the lower limbs (HP:0002166)	1.93071091
47	Hereditary nonpolyposis colorectal carcinoma (HP:0006716)	1.92361853
48	Obsessive-compulsive behavior (HP:0000722)	1.92337293
49	Cerebral aneurysm (HP:0004944)	1.92175726
50	Mild short stature (HP:0003502)	1.90299869
51	Myokymia (HP:0002411)	1.90134190
52	Gastrointestinal carcinoma (HP:0002672)	1.89408513
53	Malignant gastrointestinal tract tumors (HP:0006749)	1.89408513
54	Broad palm (HP:0001169)	1.85427994
55	Lower limb muscle weakness (HP:0007340)	1.84748642
56	Flat cornea (HP:0007720)	1.84545571
57	Heterotopia (HP:0002282)	1.84429629
58	Germ cell neoplasia (HP:0100728)	1.84005591
59	Uterine leiomyosarcoma (HP:0002891)	1.83460805
60	Leiomyosarcoma (HP:0100243)	1.83460805
61	Scanning speech (HP:0002168)	1.82620027
62	Distal upper limb amyotrophy (HP:0007149)	1.80819322
63	Upper limb amyotrophy (HP:0009129)	1.80819322
64	Transitional cell carcinoma of the bladder (HP:0006740)	1.78703122
65	Urinary bladder sphincter dysfunction (HP:0002839)	1.76755993
66	Broad metatarsal (HP:0001783)	1.76227320
67	Pointed chin (HP:0000307)	1.76019665
68	Cutaneous finger syndactyly (HP:0010554)	1.74583663
69	Metaphyseal cupping (HP:0003021)	1.74302932
70	Premature rupture of membranes (HP:0001788)	1.72635831
71	Thickened helices (HP:0000391)	1.71826214
72	Cutaneous syndactyly (HP:0012725)	1.70170627
73	Tetraplegia (HP:0002445)	1.70137898
74	Macroorchidism (HP:0000053)	1.68818733
75	Choanal stenosis (HP:0000452)	1.68195627
76	Back pain (HP:0003418)	1.67376053
77	Mitral valve prolapse (HP:0001634)	1.67320914
78	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.65955825
79	Abnormality of the diencephalon (HP:0010662)	1.65404625
80	Alacrima (HP:0000522)	1.65285789
81	Overgrowth (HP:0001548)	1.63883894
82	Cortical dysplasia (HP:0002539)	1.63811434
83	Precocious puberty (HP:0000826)	1.63454705
84	Decreased motor nerve conduction velocity (HP:0003431)	1.62360820
85	Absent frontal sinuses (HP:0002688)	1.61409310
86	Coronal craniosynostosis (HP:0004440)	1.60968397
87	Hyperextensible skin (HP:0000974)	1.59965335
88	Split foot (HP:0001839)	1.59504291
89	Intention tremor (HP:0002080)	1.58040798
90	Omphalocele (HP:0001539)	1.57467357
91	Abnormality of dentin (HP:0010299)	1.56459973
92	Bladder carcinoma (HP:0002862)	1.56198220
93	Bladder neoplasm (HP:0009725)	1.56198220
94	Visceral angiomatosis (HP:0100761)	1.55621095
95	Torticollis (HP:0000473)	1.55445111
96	Hemangiomatosis (HP:0007461)	1.54678417
97	Deviation of the hallux (HP:0010051)	1.54431260
98	Neoplasm of the heart (HP:0100544)	1.52249277
99	Depression (HP:0000716)	1.51971575
100	Aqueductal stenosis (HP:0002410)	1.51394771

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.54171026
2	EPHA4	2.67718987
3	NTRK3	2.67241341
4	LATS2	2.54228004
5	RIPK1	2.51799557
6	NTRK1	2.46026507
7	PDGFRA	2.41364827
8	CASK	2.40290830
9	TRIB3	2.35916030
10	TYRO3	2.20961518
11	KSR2	2.13946345
12	FGFR2	1.94663128
13	NTRK2	1.90909776
14	UHMK1	1.85129783
15	MAP3K10	1.83148181
16	KSR1	1.75337978
17	FGFR4	1.60016172
18	PAK6	1.57827050
19	YES1	1.43031351
20	PRKD3	1.42337835
21	MAP3K9	1.41313912
22	PKN2	1.39832553
23	CDK12	1.36427029
24	PRPF4B	1.35348726
25	RET	1.34655861
26	FGFR3	1.27116801
27	MINK1	1.26138735
28	SGK223	1.24100669
29	SGK494	1.24100669
30	NEK6	1.23275021
31	ICK	1.21651919
32	PNCK	1.19385895
33	SGK2	1.17810499
34	SGK3	1.17597041
35	EEF2K	1.14843022
36	BRD4	1.14412313
37	BCR	1.14178572
38	SMG1	1.13741872
39	MAP3K2	1.09128642
40	CAMK1G	1.07916882
41	DAPK2	1.07892326
42	ALK	1.07483838
43	MARK2	1.06287217
44	ROCK2	1.02554024
45	CAMKK1	0.99871880
46	CDK5	0.99025943
47	WNK1	0.93782624
48	LATS1	0.92216831
49	PDGFRB	0.90863580
50	DYRK1A	0.89002263
51	CDK19	0.88944885
52	SCYL2	0.87604706
53	CDK18	0.85241361
54	CDK15	0.84423441
55	FGFR1	0.84195636
56	MAPK10	0.81063325
57	STK38	0.80739001
58	DYRK1B	0.79160329
59	PTK2	0.79029113
60	CDK11A	0.78536989
61	CDK14	0.72079675
62	ERBB2	0.69791836
63	MAP2K4	0.69666355
64	PTK6	0.66167784
65	CDK6	0.65785729
66	MTOR	0.65024373
67	PRKCH	0.62902198
68	RAF1	0.62396878
69	TNIK	0.58586822
70	RPS6KB1	0.57137430
71	LMTK2	0.56826755
72	MAP3K4	0.56489440
73	BMX	0.55440169
74	MAP3K6	0.55171601
75	MKNK1	0.53906883
76	FYN	0.53875988
77	SGK1	0.52742194
78	PAK2	0.51005009
79	FES	0.49395907
80	PRKCZ	0.48226999
81	STK38L	0.48008646
82	AKT3	0.45129038
83	DMPK	0.45062293
84	ROCK1	0.44678597
85	MAP3K7	0.44652377
86	TTK	0.44209916
87	RPS6KA2	0.43979776
88	STK11	0.43614984
89	SIK2	0.43522311
90	FGR	0.42781722
91	BRAF	0.42628544
92	PLK2	0.41817232
93	PDPK1	0.41608103
94	SIK1	0.41403281
95	JAK2	0.41250198
96	CAMK2B	0.40977422
97	CSNK1G2	0.38917045
98	EPHA3	0.38814799
99	EPHB2	0.37996583
100	EPHB1	0.37648339

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Long-term potentiation_Homo sapiens_hsa04720	1.99180272
2	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.87458167
3	Endometrial cancer_Homo sapiens_hsa05213	1.85764820
4	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.73003340
5	Adherens junction_Homo sapiens_hsa04520	1.56375696
6	ErbB signaling pathway_Homo sapiens_hsa04012	1.54523954
7	Glioma_Homo sapiens_hsa05214	1.54336428
8	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.52521241
9	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.49142043
10	Colorectal cancer_Homo sapiens_hsa05210	1.47178642
11	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.45966455
12	Axon guidance_Homo sapiens_hsa04360	1.38011591
13	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.37760991
14	Estrogen signaling pathway_Homo sapiens_hsa04915	1.35763958
15	Nicotine addiction_Homo sapiens_hsa05033	1.35190419
16	Glutamatergic synapse_Homo sapiens_hsa04724	1.31605962
17	Renal cell carcinoma_Homo sapiens_hsa05211	1.31590459
18	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.31074808
19	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.30822547
20	Choline metabolism in cancer_Homo sapiens_hsa05231	1.30307933
21	Amphetamine addiction_Homo sapiens_hsa05031	1.27760983
22	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.27552442
23	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.27128065
24	Non-small cell lung cancer_Homo sapiens_hsa05223	1.26758076
25	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.22357710
26	Circadian entrainment_Homo sapiens_hsa04713	1.22030489
27	Thyroid cancer_Homo sapiens_hsa05216	1.22012978
28	Gap junction_Homo sapiens_hsa04540	1.21324798
29	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.20300227
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.19623621
31	Wnt signaling pathway_Homo sapiens_hsa04310	1.19195506
32	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.18463060
33	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.17327260
34	Melanogenesis_Homo sapiens_hsa04916	1.16129456
35	Tight junction_Homo sapiens_hsa04530	1.14005508
36	Cholinergic synapse_Homo sapiens_hsa04725	1.13744383
37	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.12546685
38	Rap1 signaling pathway_Homo sapiens_hsa04015	1.09151292
39	GABAergic synapse_Homo sapiens_hsa04727	1.08933968
40	Cocaine addiction_Homo sapiens_hsa05030	1.08844380
41	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.07769892
42	Gastric acid secretion_Homo sapiens_hsa04971	1.07440261
43	Hippo signaling pathway_Homo sapiens_hsa04390	1.05791303
44	GnRH signaling pathway_Homo sapiens_hsa04912	1.03796237
45	Notch signaling pathway_Homo sapiens_hsa04330	1.00414047
46	mTOR signaling pathway_Homo sapiens_hsa04150	1.00122078
47	Pancreatic cancer_Homo sapiens_hsa05212	0.99710433
48	VEGF signaling pathway_Homo sapiens_hsa04370	0.99597175
49	Focal adhesion_Homo sapiens_hsa04510	0.99357792
50	Long-term depression_Homo sapiens_hsa04730	0.98748636
51	Proteoglycans in cancer_Homo sapiens_hsa05205	0.98511689
52	Insulin signaling pathway_Homo sapiens_hsa04910	0.96929380
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.96116050
54	Insulin secretion_Homo sapiens_hsa04911	0.95550002
55	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.94530462
56	Amoebiasis_Homo sapiens_hsa05146	0.94407465
57	cAMP signaling pathway_Homo sapiens_hsa04024	0.94137150
58	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.93986873
59	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.92926233
60	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.92485701
61	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.92331555
62	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.91399593
63	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.88878497
64	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.87803622
65	MicroRNAs in cancer_Homo sapiens_hsa05206	0.87350641
66	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.86878341
67	Prostate cancer_Homo sapiens_hsa05215	0.86674486
68	Prolactin signaling pathway_Homo sapiens_hsa04917	0.86171265
69	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.85976645
70	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.84354849
71	AMPK signaling pathway_Homo sapiens_hsa04152	0.83581142
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.83165604
73	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.82159814
74	Acute myeloid leukemia_Homo sapiens_hsa05221	0.81629530
75	Prion diseases_Homo sapiens_hsa05020	0.81557244
76	Endocytosis_Homo sapiens_hsa04144	0.80958340
77	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.79823644
78	Basal cell carcinoma_Homo sapiens_hsa05217	0.79044549
79	Bile secretion_Homo sapiens_hsa04976	0.77130971
80	Type II diabetes mellitus_Homo sapiens_hsa04930	0.76773295
81	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.75808246
82	Morphine addiction_Homo sapiens_hsa05032	0.75739725
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.75269684
84	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.75132379
85	ECM-receptor interaction_Homo sapiens_hsa04512	0.74465615
86	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.73855321
87	Renin secretion_Homo sapiens_hsa04924	0.73386864
88	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.72126429
89	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.71791251
90	Ras signaling pathway_Homo sapiens_hsa04014	0.70794058
91	Oocyte meiosis_Homo sapiens_hsa04114	0.69559258
92	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.67917979
93	Protein digestion and absorption_Homo sapiens_hsa04974	0.65887036
94	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62864656
95	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.62187499
96	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.61820107
97	Glucagon signaling pathway_Homo sapiens_hsa04922	0.59852365
98	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.58610205
99	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.58161543
100	mRNA surveillance pathway_Homo sapiens_hsa03015	0.57599717

GTF2IP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »